Molecular Weight:   | 192.04 |
Volume:   | 186.382 |
LogP:   | 1.186 |
LogD:   | 1.33 |
LogS:   | -2.206 |
# Rotatable Bonds:   | 1 |
TPSA:   | 59.67 |
# H-Bond Aceptor:   | 4 |
# H-Bond Donor:   | 1 |
# Rings:   | 2 |
# Heavy Atoms:   | 4 |
QED Drug-Likeness Score:   | 0.695 |
Synthetic Accessibility Score:   | 2.05 |
Fsp3:   | 0.1 |
Lipinski Rule-of-5:   | Accepted |
Pfizer Rule:   | Accepted |
GSK Rule:   | Accepted |
BMS Rule:   | 0 |
Golden Triangle Rule:   | Rejected |
Chelating Alert:   | 1 |
PAINS Alert:   | 0 |
Caco-2 Permeability:   | -4.727 |
MDCK Permeability:   | 1.6060675989137962e-05 |
Pgp-inhibitor:   | 0.003 |
Pgp-substrate:   | 0.945 |
Human Intestinal Absorption (HIA):   | 0.009 |
20% Bioavailability (F20%):   | 0.225 |
30% Bioavailability (F30%):   | 0.998 |
Blood-Brain-Barrier Penetration (BBB):   | 0.166 |
Plasma Protein Binding (PPB):   | 83.35882568359375% |
Volume Distribution (VD):   | 0.691 |
Pgp-substrate:   | 19.470502853393555% |
CYP1A2-inhibitor:   | 0.969 |
CYP1A2-substrate:   | 0.949 |
CYP2C19-inhibitor:   | 0.164 |
CYP2C19-substrate:   | 0.076 |
CYP2C9-inhibitor:   | 0.05 |
CYP2C9-substrate:   | 0.839 |
CYP2D6-inhibitor:   | 0.446 |
CYP2D6-substrate:   | 0.868 |
CYP3A4-inhibitor:   | 0.312 |
CYP3A4-substrate:   | 0.3 |
Clearance (CL):   | 13.326 |
Half-life (T1/2):   | 0.837 |
hERG Blockers:   | 0.097 |
Human Hepatotoxicity (H-HT):   | 0.25 |
Drug-inuced Liver Injury (DILI):   | 0.799 |
AMES Toxicity:   | 0.061 |
Rat Oral Acute Toxicity:   | 0.068 |
Maximum Recommended Daily Dose:   | 0.391 |
Skin Sensitization:   | 0.563 |
Carcinogencity:   | 0.602 |
Eye Corrosion:   | 0.342 |
Eye Irritation:   | 0.978 |
Respiratory Toxicity:   | 0.22 |
Natural Product ID:   | NPC139548 |
Common Name*:   | Isoscopoletin |
IUPAC Name:   | 6-hydroxy-7-methoxychromen-2-one |
Synonyms:   | Isoscopoletin; Isoscopoletine |
Standard InCHIKey:   | SYTYLPHCLSSCOJ-UHFFFAOYSA-N |
Standard InCHI:   | InChI=1S/C10H8O4/c1-13-9-5-8-6(4-7(9)11)2-3-10(12)14-8/h2-5,11H,1H3 |
SMILES:   | COc1cc2c(ccc(=O)o2)cc1O |
Synthetic Gene Cluster:   | n.a. |
ChEMBL Identifier:   | CHEMBL390320 |
PubChem CID:   |
69894 |
Chemical Classification**:   |
|
*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.
Organism ID | Organism Name | Taxonomy Level | Family | SuperKingdom | Isolation Part | Collection Location | Collection Time | Reference |
---|---|---|---|---|---|---|---|---|
NPO2768 | Berchemia floribunda | Species | Rhamnaceae | Eukaryota | n.a. | n.a. | n.a. | DOI[10.1002/cbdv.200690067] |
NPO6915 | Chloranthus japonicus | Species | Chloranthaceae | Eukaryota | n.a. | whole plant | n.a. | DOI[10.1016/j.phytol.2016.01.005] |
NPO11979 | Bugula neritina | Species | Bugulidae | Eukaryota | n.a. | n.a. | n.a. | DOI[10.1021/ja00388a092] |
NPO21390 | Zanthoxylum integrifoliolum | Species | Rutaceae | Eukaryota | fruit | Lanyu Island, Taitung County, Taiwan | n.a. |
PMID[10395498] |
NPO10467 | Resupinatus leightonii | Species | Tricholomataceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[11000039] |
NPO11702 | Plexaurella grisea | Species | Plexauridae | Eukaryota | n.a. | n.a. | n.a. |
PMID[11325216] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | n.a. | leaf | n.a. |
PMID[11348221] |
NPO17377 | Pittosporum viridiflorum | Species | Pittosporaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[11809069] |
NPO17823 | Lycium chinense | Species | Solanaceae | Eukaryota | fruits | n.a. | n.a. |
PMID[12467621] |
NPO15579 | Mycale laxissima | Species | Mycalidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[12932129] |
NPO25302 | Viola philippica | Species | Violaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[14519932] |
NPO11616 | Vibrio parahaemolyticus | Species | Vibrionaceae | Bacteria | n.a. | North Sea | n.a. |
PMID[14640534] |
NPO7587 | Mallotus resinosus | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[15387675] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | fruit | n.a. | n.a. |
PMID[15844957] |
NPO11357 | Nephelium lappaceum | Species | Sapindaceae | Eukaryota | Seeds | n.a. | n.a. |
PMID[16180821] |
NPO17823 | Lycium chinense | Species | Solanaceae | Eukaryota | n.a. | root | n.a. |
PMID[16212233] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | fruits | n.a. | n.a. |
PMID[16378361] |
NPO16634 | Sinularia manaarensis | Species | Alcyoniidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[16933863] |
NPO7664 | Pseudocedrela kotschyi | Species | Meliaceae | Eukaryota | roots | n.a. | n.a. |
PMID[17253841] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | fruits | Tahiti | n.a. |
PMID[17378609] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | Fruits | n.a. | n.a. |
PMID[17480098] |
NPO21390 | Zanthoxylum integrifoliolum | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[17822293] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | roots | n.a. | n.a. |
PMID[18076142] |
NPO6915 | Chloranthus japonicus | Species | Chloranthaceae | Eukaryota | n.a. | whole plant | n.a. |
PMID[18451544] |
NPO13975 | Calanthe arisanensis | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[18640035] |
NPO13975 | Calanthe arisanensis | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[19193043] |
NPO5018 | Nervilia fordii | Species | Orchidaceae | Eukaryota | whole plant | n.a. | n.a. |
PMID[19422205] |
NPO6915 | Chloranthus japonicus | Species | Chloranthaceae | Eukaryota | whole plants | Suiling district, Heilongjiang Province, China | 2008-AUG |
PMID[21142110] |
NPO6915 | Chloranthus japonicus | Species | Chloranthaceae | Eukaryota | Whole plant | Suiling district, Heilongjiang Province, China | 2008-AUG |
PMID[21142110] |
NPO6915 | Chloranthus japonicus | Species | Chloranthaceae | Eukaryota | n.a. | whole plant | n.a. |
PMID[21142110] |
NPO6915 | Chloranthus japonicus | Species | Chloranthaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[21650224] |
NPO6915 | Chloranthus japonicus | Species | Chloranthaceae | Eukaryota | n.a. | whole plant | n.a. |
PMID[21650224] |
NPO5258 | Fagara zanthoxyloides | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. |
PMID[22472691] |
NPO17823 | Lycium chinense | Species | Solanaceae | Eukaryota | root bark | n.a. | n.a. |
PMID[23282106] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[24224843] |
NPO11979 | Bugula neritina | Species | Bugulidae | Eukaryota | n.a. | South China Sea | n.a. |
PMID[25932671] |
NPO18671 | Saussurea involucrata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[26214875] |
NPO17823 | Lycium chinense | Species | Solanaceae | Eukaryota | Root Bark | n.a. | n.a. |
PMID[26982999] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[27196335] |
NPO15933 | Dysoxylum binectariferum | Species | Meliaceae | Eukaryota | leaves | n.a. | n.a. |
PMID[27363938] |
NPO2722 | Humulus japonicus | Species | Cannabaceae | Eukaryota | Aerial Parts | n.a. | n.a. |
PMID[29254897] |
NPO23429 | Lycium barbarum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[31397570] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | Fruits | n.a. | n.a. |
PMID[32083868] |
NPO26277 | Euphorbia hirta | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. |
PMID[32141299] |
NPO21322 | Plinia cauliflora | Species | Myrtaceae | Eukaryota | leaves | n.a. | n.a. |
PMID[32706260] |
NPO11616 | Vibrio parahaemolyticus | Species | Vibrionaceae | Bacteria | n.a. | n.a. | n.a. |
PMID[7853008] |
NPO11979 | Bugula neritina | Species | Bugulidae | Eukaryota | n.a. | Gulf of Aomori, Japan | n.a. |
PMID[8691208] |
NPO10969 | Epimedium sagittatum | Species | Berberidaceae | Eukaryota | n.a. | leaf | n.a. |
PMID[8699184] |
NPO11979 | Bugula neritina | Species | Bugulidae | Eukaryota | n.a. | n.a. | n.a. |
PMID[8882431] |
NPO17823 | Lycium chinense | Species | Solanaceae | Eukaryota | fruits | n.a. | n.a. |
PMID[9090870] |
NPO16120 | Swertia decora | Species | Gentianaceae | Eukaryota | n.a. | n.a. | n.a. | Database[Article] |
NPO11616 | Vibrio parahaemolyticus | Species | Vibrionaceae | Bacteria | n.a. | n.a. | n.a. | DOI[DOI: 10.1111/j.1574-6968.1992.tb05311.x] |
NPO11357 | Nephelium lappaceum | Species | Sapindaceae | Eukaryota | n.a. | n.a. | Database[FooDB] | |
NPO15212 | Fraxinus chinensis | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO15730 | Citrus medica | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO14650 | Lobelia chinensis | Species | Campanulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO2722 | Humulus japonicus | Species | Cannabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO15413 | Glycyrrhiza pallidiflora | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO4307 | Canarium album | Species | Burseraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO18671 | Saussurea involucrata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO9661 | Fraxinus szaboana | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO23429 | Lycium barbarum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO6915 | Chloranthus japonicus | Species | Chloranthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO3564 | Fraxinus stylosa | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO10969 | Epimedium sagittatum | Species | Berberidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO26277 | Euphorbia hirta | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO22524 | Ranunculus sceleratus | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO24301.1 | Buxus microphylla var. sinica | Varieties | Buxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO358 | Uncaria guianensis | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO18681 | Artemisia scoparia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO17823 | Lycium chinense | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO12755 | Siphonostegia chinensis | Species | Orobanchaceae | Eukaryota | n.a. | n.a. | n.a. | Database[HerDing] |
NPO18671 | Saussurea involucrata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO15151 | Syringa vulgaris | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22524 | Ranunculus sceleratus | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO25302 | Viola philippica | Species | Violaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO12755 | Siphonostegia chinensis | Species | Orobanchaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO15212.1 | Fraxinus chinensis subsp. rhynchophylla | Subspecies | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO4307 | Canarium album | Species | Burseraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO2722 | Humulus japonicus | Species | Cannabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO22541 | Channa argus | Species | Channidae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21413 | Armillaria tabescens | Species | Physalacriaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO3564 | Fraxinus stylosa | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO7446 | Erythrina eriotriocha | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO6915 | Chloranthus japonicus | Species | Chloranthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO15933 | Dysoxylum binectariferum | Species | Meliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO21390 | Zanthoxylum integrifoliolum | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO14650 | Lobelia chinensis | Species | Campanulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO15904 | Chrysosplenium oppositifolium | Species | Saxifragaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO15413 | Glycyrrhiza pallidiflora | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO14127 | Veratrum eschscholtzii | Species | Melanthiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO15212 | Fraxinus chinensis | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO17823 | Lycium chinense | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO15730 | Citrus medica | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO15057 | Isodon gesneroides | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO24301.1 | Buxus microphylla var. sinica | Varieties | Buxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO26277 | Euphorbia hirta | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO23429 | Lycium barbarum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO18681 | Artemisia scoparia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO9661 | Fraxinus szaboana | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO10969 | Epimedium sagittatum | Species | Berberidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO358 | Uncaria guianensis | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO9964 | Aglaia lawii | Species | Meliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO581 | Conyza bonariensis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCMID] |
NPO4307 | Canarium album | Species | Burseraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO12755 | Siphonostegia chinensis | Species | Orobanchaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO2722 | Humulus japonicus | Species | Cannabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO21924 | Althaea officinalis | Species | Malvaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO15413 | Glycyrrhiza pallidiflora | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO14650 | Lobelia chinensis | Species | Campanulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO10969 | Epimedium sagittatum | Species | Berberidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO9661 | Fraxinus szaboana | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO3564 | Fraxinus stylosa | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO15212 | Fraxinus chinensis | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO18681 | Artemisia scoparia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO24301.2 | Buxus microphylla sieb. et zucc. var. sinica rehd. et wils. | Varieties | Buxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO23429 | Lycium barbarum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO17823 | Lycium chinense | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO15730 | Citrus medica | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TCM_Taiwan] |
NPO18671 | Saussurea involucrata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO15212 | Fraxinus chinensis | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO15212.1 | Fraxinus chinensis subsp. rhynchophylla | Subspecies | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO3564 | Fraxinus stylosa | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO17823 | Lycium chinense | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO26277 | Euphorbia hirta | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO4307 | Canarium album | Species | Burseraceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO14650 | Lobelia chinensis | Species | Campanulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO10969 | Epimedium sagittatum | Species | Berberidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO12755 | Siphonostegia chinensis | Species | Orobanchaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO25302 | Viola philippica | Species | Violaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO9661 | Fraxinus szaboana | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO15730 | Citrus medica | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO23429 | Lycium barbarum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO8837 | Viola mandshurica | Species | Violaceae | Eukaryota | n.a. | n.a. | n.a. | Database[TM-MC] |
NPO8298 | Sphaeria biglobosa | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13296 | Pinus sitchensis | Species | Pinaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16526 | Papularia sphaerosperma | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO6469 | Clematis angustifolia | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO6899 | Hepialus hecta | Species | Hepialidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15027 | Helianthus divaricatus | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5824 | Hygrophila polysperma | Species | Acanthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO29072 | Tritomaria quinquedentata | Species | Scapaniaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5473 | Streptomyces orinoci | Species | Streptomycetaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15904 | Chrysosplenium oppositifolium | Species | Saxifragaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9964 | Aglaia lawii | Species | Meliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO581 | Conyza bonariensis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15194 | Euphorbia balsamifera | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15972 | Quercus gilva | Species | Fagaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16553 | Theonella cupola | Species | Theonellidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22541 | Channa argus | Species | Channidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7664 | Pseudocedrela kotschyi | Species | Meliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO26942 | Vicoa vestita | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16888 | Sophora davidii | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13773 | Eriogonum nudum | Species | Polygonaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14127 | Veratrum eschscholtzii | Species | Melanthiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1354 | Myelochroa rhytidodes | Species | Parmeliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3084 | Xylopia brasiliensis | Species | Annonaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14650 | Lobelia chinensis | Species | Campanulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21322 | Plinia cauliflora | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27425 | Pseudotaxus chienii | Species | Taxaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17117 | Diaporthe amygdali | Species | Diaporthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5258 | Fagara zanthoxyloides | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16713 | Choisya arizonica | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14896 | Reaumuria mucronata | Species | Tamaricaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12034 | Dictamnus gymnostylis | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO27420 | Venidium hirsutum | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15057 | Isodon gesneroides | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13410 | Mcneillia graminifolia | Species | Caryophyllaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11702 | Plexaurella grisea | Species | Plexauridae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO28881 | Virola sebifera | Species | Myristicaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12378 | Streptomyces blastmyceticus | Species | Streptomycetaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15212 | Fraxinus chinensis | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13257 | Euphorbia officinarum | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15212.1 | Fraxinus chinensis subsp. rhynchophylla | Subspecies | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4307 | Canarium album | Species | Burseraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1933 | Sideritis nutans | Species | Lamiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15151 | Syringa vulgaris | Species | Oleaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11979 | Bugula neritina | Species | Bugulidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16634 | Sinularia manaarensis | Species | Alcyoniidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO14625 | Santolina rosmarinifolia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16466 | Baccharis santelicis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO18671 | Saussurea involucrata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16439 | Alphitonia macrocarpa | Species | Rhamnaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21924 | Althaea officinalis | Species | Malvaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9781 | Hyphear tanakae | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21413 | Armillaria tabescens | Species | Physalacriaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3619 | Ilex hainanensis | Species | Aquifoliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7201 | Rhodopila globiformis | Species | Acetobacteraceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO752 | Oligonychus bessardi | Species | Tetranychidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8782 | Arnica sachalinensis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15691 | Senecio coahuilensis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1660 | Ligularia subspicata | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO816 | Stenomesson miniatum | Species | Amaryllidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10396 | Pteris australis | Species | Pteridaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12755 | Siphonostegia chinensis | Species | Orobanchaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5868 | Morus rubra | Species | Moraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16313 | Ochrocarpos odoratus | Species | Clusiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16878 | Roldana barba-johannis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4323 | Morinda citrifolia | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21773 | Rothmannia urcelliformis | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9073 | Withania frutescens | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9150 | Polypodiodes formosana | Species | Polypodiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9425 | Punctelia microsticta | Species | Parmeliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13130 | 0tholaena peninsularis | Species | Pteridaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO358 | Uncaria guianensis | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16223 | Serratula xeranthemoides | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15452 | Senecio othonniformis | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO25302 | Viola philippica | Species | Violaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10467 | Resupinatus leightonii | Species | Tricholomataceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15579 | Mycale laxissima | Species | Mycalidae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21171 | Rubus thibetanus | Species | Rosaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9728 | Quercus acuta | Species | Fagaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO4676 | Melicope sarcococca | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO8216 | Garcinia volkensii | Species | Clusiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3488 | Glossocalyx brevipes | Species | Siparunaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO12087 | Amaioua guianensis | Species | Rubiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11241 | Arisarum vulgare | Species | Araceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO10969 | Epimedium sagittatum | Species | Berberidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1321 | Centaurea spruneri | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11413 | Incarvillea emodi | Species | Bignoniaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17447 | Agathosma betulina | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7446 | Erythrina eriotriocha | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2768 | Berchemia floribunda | Species | Rhamnaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11117 | Xerula melanotricha | Species | Physalacriaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17377 | Pittosporum viridiflorum | Species | Pittosporaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13005 | Aplophyllum telephioides | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO13975 | Calanthe arisanensis | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16789 | Erythrina sandwicensis | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15341 | Mucuna sloanei | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15730 | Citrus medica | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11478 | Aniba duckei | Species | Lauraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO5018 | Nervilia fordii | Species | Orchidaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15413 | Glycyrrhiza pallidiflora | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO3742 | Betula maximowicziana | Species | Betulaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11616 | Vibrio parahaemolyticus | Species | Vibrionaceae | Bacteria | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22524 | Ranunculus sceleratus | Species | Ranunculaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO22394 | Hyacinthoides hispanica | Species | Hyacinthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11895 | Nama johnstonii | Species | Namaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO17823 | Lycium chinense | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO26277 | Euphorbia hirta | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO6915 | Chloranthus japonicus | Species | Chloranthaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO21390 | Zanthoxylum integrifoliolum | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15933 | Dysoxylum binectariferum | Species | Meliaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO18681 | Artemisia scoparia | Species | Asteraceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO2722 | Humulus japonicus | Species | Cannabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO16120 | Swertia decora | Species | Gentianaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO23429 | Lycium barbarum | Species | Solanaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO15762 | Eucalyptus sieberiana | Species | Myrtaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO24059 | Agathosma recurvifolia | Species | Rutaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO7587 | Mallotus resinosus | Species | Euphorbiaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO9827 | Indigofera linnaei | Species | Fabaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
NPO1780 | Sphaeria doliolum | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | Database[UNPD] |
NPO11357 | Nephelium lappaceum | Species | Sapindaceae | Eukaryota | n.a. | n.a. | n.a. | Database[UNPD] |
☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
---|
☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Target ID | Target Type | Target Name | Target Organism | Activity Type | Activity Relation | Value | Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPT570 | Individual Protein | Arachidonate 5-lipoxygenase | Homo sapiens | IC50 | > | 100000.0 | nM | PMID[546207] |
NPT257 | Individual Protein | Arachidonate 15-lipoxygenase | Oryctolagus cuniculus | IC50 | = | 15100.0 | nM | PMID[546207] |
NPT31 | Individual Protein | Cyclooxygenase-2 | Homo sapiens | IC50 | > | 100000.0 | nM | PMID[546207] |
NPT2740 | Cell Line | Neutrophils | IC50 | = | 77520.0 | nM | PMID[546209] | |
NPT41 | Individual Protein | Aldose reductase | Homo sapiens | IC50 | = | 56200.0 | nM | PMID[546211] |
NPT1551 | Individual Protein | Sorbitol dehydrogenase | Homo sapiens | IC50 | > | 250000.0 | nM | PMID[546211] |
NPT199 | Individual Protein | DNA polymerase kappa | Homo sapiens | Potency | n.a. | 23778.1 | nM | PMID[546212] |
NPT66 | Individual Protein | Acetylcholinesterase | Electrophorus electricus | Inhibition | = | 28.07 | % | PMID[546213] |
NPT3101 | Individual Protein | Carbonic anhydrase XIII | Homo sapiens | Ki | = | 5270.0 | nM | PMID[546214] |
NPT233 | Individual Protein | Carbonic anhydrase II | Homo sapiens | Ki | > | 100000.0 | nM | PMID[546214] |
NPT43 | Individual Protein | Tyrosinase | Agaricus bisporus | Inhibition | > | 30.0 | % | PMID[546216] |
NPT461 | Cell Line | PANC-1 | Homo sapiens | PC50 | = | 26.9 | uM | PMID[546217] |
NPT57 | Individual Protein | Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens | Ki | = | 15870.0 | nM | PMID[546218] |
NPT57 | Individual Protein | Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens | IC50 | = | 51480.0 | nM | PMID[546218] |
NPT967 | Individual Protein | Xanthine dehydrogenase | Homo sapiens | IC50 | = | 138000.0 | nM | PMID[546208] |
NPT2 | Others | Unspecified | Activity | = | 42.0 | % | PMID[546210] | |
NPT2 | Others | Unspecified | Activity | = | 2.0 | % | PMID[546210] | |
NPT2 | Others | Unspecified | Activity | = | 26.0 | % | PMID[546210] | |
NPT2 | Others | Unspecified | Activity | = | 14.0 | % | PMID[546210] | |
NPT2 | Others | Unspecified | IC50 | = | 101000.0 | nM | PMID[546211] | |
NPT2 | Others | Unspecified | Ratio IC50 | > | 2.48 | n.a. | PMID[546211] | |
NPT2 | Others | Unspecified | Ratio IC50 | = | 0.56 | n.a. | PMID[546211] | |
NPT67 | Individual Protein | Cholinesterase | Equus caballus | Inhibition | = | 3.87 | % | PMID[546213] |
NPT955 | Individual Protein | Carbonic anhydrase VII | Homo sapiens | Ki | = | 23800.0 | nM | PMID[546214] |
NPT947 | Individual Protein | Carbonic anhydrase I | Homo sapiens | Ki | = | 14000.0 | nM | PMID[546214] |
NPT948 | Individual Protein | Carbonic anhydrase IX | Homo sapiens | Ki | = | 7370.0 | nM | PMID[546214] |
NPT949 | Individual Protein | Carbonic anhydrase XII | Homo sapiens | Ki | = | 4140.0 | nM | PMID[546214] |
NPT2 | Others | Unspecified | IC50 | = | 32200000.0 | nM | PMID[546215] |
☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.
Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC139548 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Natural Product ID |
---|---|---|
1.0 | High Similarity | NPC20511 |
1.0 | High Similarity | NPC76336 |
1.0 | High Similarity | NPC95162 |
1.0 | High Similarity | NPC52086 |
1.0 | High Similarity | NPC148835 |
0.9924 | High Similarity | NPC13067 |
0.9923 | High Similarity | NPC126682 |
0.9923 | High Similarity | NPC82271 |
0.9769 | High Similarity | NPC92830 |
0.9692 | High Similarity | NPC26673 |
0.9615 | High Similarity | NPC137949 |
0.9542 | High Similarity | NPC277021 |
0.9538 | High Similarity | NPC73738 |
0.9485 | High Similarity | NPC256555 |
0.9485 | High Similarity | NPC110067 |
0.9485 | High Similarity | NPC236419 |
0.9485 | High Similarity | NPC91492 |
0.9485 | High Similarity | NPC7439 |
0.9485 | High Similarity | NPC34245 |
0.9478 | High Similarity | NPC164148 |
0.9478 | High Similarity | NPC43500 |
0.9462 | High Similarity | NPC244799 |
0.9462 | High Similarity | NPC240722 |
0.9385 | High Similarity | NPC27239 |
0.9385 | High Similarity | NPC123127 |
0.9353 | High Similarity | NPC231149 |
0.9343 | High Similarity | NPC230157 |
0.9338 | High Similarity | NPC300611 |
0.9318 | High Similarity | NPC137669 |
0.9286 | High Similarity | NPC139839 |
0.9259 | High Similarity | NPC38874 |
0.9248 | High Similarity | NPC233018 |
0.9248 | High Similarity | NPC36437 |
0.9248 | High Similarity | NPC241341 |
0.922 | High Similarity | NPC176903 |
0.922 | High Similarity | NPC30688 |
0.9203 | High Similarity | NPC138212 |
0.9179 | High Similarity | NPC309953 |
0.9179 | High Similarity | NPC111635 |
0.9155 | High Similarity | NPC205727 |
0.9155 | High Similarity | NPC120426 |
0.9155 | High Similarity | NPC21184 |
0.9155 | High Similarity | NPC294522 |
0.9149 | High Similarity | NPC48366 |
0.9137 | High Similarity | NPC185127 |
0.9137 | High Similarity | NPC471763 |
0.9118 | High Similarity | NPC474886 |
0.9104 | High Similarity | NPC474810 |
0.9091 | High Similarity | NPC213197 |
0.9085 | High Similarity | NPC313334 |
0.9085 | High Similarity | NPC206264 |
0.9085 | High Similarity | NPC212670 |
0.9078 | High Similarity | NPC178129 |
0.9078 | High Similarity | NPC476347 |
0.9077 | High Similarity | NPC300326 |
0.9077 | High Similarity | NPC58279 |
0.9065 | High Similarity | NPC6568 |
0.9044 | High Similarity | NPC167517 |
0.903 | High Similarity | NPC319969 |
0.903 | High Similarity | NPC245120 |
0.9028 | High Similarity | NPC120774 |
0.9028 | High Similarity | NPC163598 |
0.9028 | High Similarity | NPC264875 |
0.9023 | High Similarity | NPC19242 |
0.9015 | High Similarity | NPC109275 |
0.9014 | High Similarity | NPC187398 |
0.9014 | High Similarity | NPC476348 |
0.9007 | High Similarity | NPC205361 |
0.8993 | High Similarity | NPC469564 |
0.8978 | High Similarity | NPC20796 |
0.8971 | High Similarity | NPC240915 |
0.8971 | High Similarity | NPC472521 |
0.8971 | High Similarity | NPC234865 |
0.8955 | High Similarity | NPC142530 |
0.8955 | High Similarity | NPC147317 |
0.8947 | High Similarity | NPC45824 |
0.8947 | High Similarity | NPC48315 |
0.8944 | High Similarity | NPC41844 |
0.8944 | High Similarity | NPC15577 |
0.8936 | High Similarity | NPC476450 |
0.8913 | High Similarity | NPC270256 |
0.8905 | High Similarity | NPC309031 |
0.8905 | High Similarity | NPC286843 |
0.8897 | High Similarity | NPC7163 |
0.8881 | High Similarity | NPC214860 |
0.8881 | High Similarity | NPC96294 |
0.8855 | High Similarity | NPC183446 |
0.8841 | High Similarity | NPC476171 |
0.8841 | High Similarity | NPC105493 |
0.8832 | High Similarity | NPC73071 |
0.8832 | High Similarity | NPC252095 |
0.8824 | High Similarity | NPC472522 |
0.8797 | High Similarity | NPC216836 |
0.8786 | High Similarity | NPC279851 |
0.8786 | High Similarity | NPC472520 |
0.8779 | High Similarity | NPC238810 |
0.8769 | High Similarity | NPC310373 |
0.8759 | High Similarity | NPC474600 |
0.8759 | High Similarity | NPC106215 |
0.8759 | High Similarity | NPC114740 |
0.875 | High Similarity | NPC123954 |
0.875 | High Similarity | NPC5423 |
0.875 | High Similarity | NPC474635 |
0.8731 | High Similarity | NPC474616 |
0.8705 | High Similarity | NPC276328 |
0.8696 | High Similarity | NPC472337 |
0.8692 | High Similarity | NPC302107 |
0.8692 | High Similarity | NPC307253 |
0.8686 | High Similarity | NPC168059 |
0.8686 | High Similarity | NPC229442 |
0.8681 | High Similarity | NPC275125 |
0.8681 | High Similarity | NPC170239 |
0.8681 | High Similarity | NPC97937 |
0.8676 | High Similarity | NPC82503 |
0.8667 | High Similarity | NPC10225 |
0.8667 | High Similarity | NPC58164 |
0.8657 | High Similarity | NPC194841 |
0.8657 | High Similarity | NPC474670 |
0.8647 | High Similarity | NPC27352 |
0.8647 | High Similarity | NPC271985 |
0.8633 | High Similarity | NPC26954 |
0.8633 | High Similarity | NPC472334 |
0.8633 | High Similarity | NPC472336 |
0.8633 | High Similarity | NPC38099 |
0.8626 | High Similarity | NPC187868 |
0.8626 | High Similarity | NPC285289 |
0.8626 | High Similarity | NPC52247 |
0.8623 | High Similarity | NPC147030 |
0.8623 | High Similarity | NPC326600 |
0.8623 | High Similarity | NPC50896 |
0.8623 | High Similarity | NPC204353 |
0.8621 | High Similarity | NPC478237 |
0.8615 | High Similarity | NPC247553 |
0.8615 | High Similarity | NPC2058 |
0.8613 | High Similarity | NPC202762 |
0.8613 | High Similarity | NPC161203 |
0.8613 | High Similarity | NPC86655 |
0.8613 | High Similarity | NPC194277 |
0.8611 | High Similarity | NPC40222 |
0.8611 | High Similarity | NPC268515 |
0.8611 | High Similarity | NPC287275 |
0.8603 | High Similarity | NPC299221 |
0.8603 | High Similarity | NPC311680 |
0.8603 | High Similarity | NPC51840 |
0.8603 | High Similarity | NPC220935 |
0.8603 | High Similarity | NPC91291 |
0.8603 | High Similarity | NPC234488 |
0.8593 | High Similarity | NPC474651 |
0.8593 | High Similarity | NPC19694 |
0.8593 | High Similarity | NPC474623 |
0.8592 | High Similarity | NPC472332 |
0.8592 | High Similarity | NPC472335 |
0.8582 | High Similarity | NPC127604 |
0.8582 | High Similarity | NPC476006 |
0.8582 | High Similarity | NPC267291 |
0.8581 | High Similarity | NPC150442 |
0.8571 | High Similarity | NPC281014 |
0.8571 | High Similarity | NPC474282 |
0.8571 | High Similarity | NPC184861 |
0.8571 | High Similarity | NPC126206 |
0.8571 | High Similarity | NPC326797 |
0.8571 | High Similarity | NPC225106 |
0.8571 | High Similarity | NPC212124 |
0.8571 | High Similarity | NPC102904 |
0.8571 | High Similarity | NPC107551 |
0.8571 | High Similarity | NPC294456 |
0.8571 | High Similarity | NPC176051 |
0.8571 | High Similarity | NPC276490 |
0.8571 | High Similarity | NPC103976 |
0.8562 | High Similarity | NPC113790 |
0.8562 | High Similarity | NPC107636 |
0.8561 | High Similarity | NPC33986 |
0.8561 | High Similarity | NPC194626 |
0.8552 | High Similarity | NPC52740 |
0.8551 | High Similarity | NPC36661 |
0.8551 | High Similarity | NPC94236 |
0.8551 | High Similarity | NPC37196 |
0.8551 | High Similarity | NPC163557 |
0.8551 | High Similarity | NPC36490 |
0.8542 | High Similarity | NPC125617 |
0.854 | High Similarity | NPC29734 |
0.8538 | High Similarity | NPC298796 |
0.8523 | High Similarity | NPC8712 |
0.8521 | High Similarity | NPC83375 |
0.8521 | High Similarity | NPC224876 |
0.8519 | High Similarity | NPC121740 |
0.8519 | High Similarity | NPC224774 |
0.8519 | High Similarity | NPC258567 |
0.8519 | High Similarity | NPC474821 |
0.8519 | High Similarity | NPC210355 |
0.8514 | High Similarity | NPC169404 |
0.8514 | High Similarity | NPC53587 |
0.8514 | High Similarity | NPC176186 |
0.8511 | High Similarity | NPC25966 |
0.8511 | High Similarity | NPC151946 |
0.8511 | High Similarity | NPC127218 |
0.8511 | High Similarity | NPC245207 |
0.8511 | High Similarity | NPC319647 |
0.8507 | High Similarity | NPC244495 |
0.8507 | High Similarity | NPC93219 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC139548 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Drug ID | Developmental Stage |
---|---|---|---|
0.9085 | High Similarity | NPD1653 | Approved |
0.8626 | High Similarity | NPD422 | Phase 1 |
0.8456 | Intermediate Similarity | NPD1529 | Clinical (unspecified phase) |
0.8382 | Intermediate Similarity | NPD1530 | Clinical (unspecified phase) |
0.8345 | Intermediate Similarity | NPD1613 | Approved |
0.8345 | Intermediate Similarity | NPD1612 | Clinical (unspecified phase) |
0.8278 | Intermediate Similarity | NPD2801 | Approved |
0.8129 | Intermediate Similarity | NPD3027 | Phase 3 |
0.8041 | Intermediate Similarity | NPD1511 | Approved |
0.8028 | Intermediate Similarity | NPD447 | Suspended |
0.8028 | Intermediate Similarity | NPD230 | Phase 1 |
0.8014 | Intermediate Similarity | NPD1652 | Phase 2 |
0.7974 | Intermediate Similarity | NPD1934 | Approved |
0.7935 | Intermediate Similarity | NPD4868 | Clinical (unspecified phase) |
0.7933 | Intermediate Similarity | NPD1512 | Approved |
0.7922 | Intermediate Similarity | NPD1465 | Phase 2 |
0.7871 | Intermediate Similarity | NPD3817 | Phase 2 |
0.7826 | Intermediate Similarity | NPD4379 | Clinical (unspecified phase) |
0.7821 | Intermediate Similarity | NPD3882 | Suspended |
0.7815 | Intermediate Similarity | NPD1940 | Clinical (unspecified phase) |
0.7786 | Intermediate Similarity | NPD228 | Approved |
0.7778 | Intermediate Similarity | NPD5844 | Phase 1 |
0.7778 | Intermediate Similarity | NPD1548 | Phase 1 |
0.7737 | Intermediate Similarity | NPD3496 | Discontinued |
0.7703 | Intermediate Similarity | NPD970 | Clinical (unspecified phase) |
0.7697 | Intermediate Similarity | NPD4338 | Clinical (unspecified phase) |
0.7697 | Intermediate Similarity | NPD7549 | Discontinued |
0.7692 | Intermediate Similarity | NPD2393 | Clinical (unspecified phase) |
0.7676 | Intermediate Similarity | NPD1008 | Clinical (unspecified phase) |
0.7655 | Intermediate Similarity | NPD5124 | Phase 1 |
0.7655 | Intermediate Similarity | NPD5123 | Clinical (unspecified phase) |
0.7607 | Intermediate Similarity | NPD3818 | Discontinued |
0.7606 | Intermediate Similarity | NPD3018 | Phase 2 |
0.76 | Intermediate Similarity | NPD3750 | Approved |
0.7569 | Intermediate Similarity | NPD6859 | Clinical (unspecified phase) |
0.7568 | Intermediate Similarity | NPD1551 | Phase 2 |
0.7561 | Intermediate Similarity | NPD7054 | Approved |
0.7554 | Intermediate Similarity | NPD1610 | Phase 2 |
0.7532 | Intermediate Similarity | NPD5402 | Approved |
0.7518 | Intermediate Similarity | NPD3225 | Approved |
0.7517 | Intermediate Similarity | NPD7266 | Discontinued |
0.7515 | Intermediate Similarity | NPD7472 | Approved |
0.75 | Intermediate Similarity | NPD919 | Approved |
0.7485 | Intermediate Similarity | NPD6167 | Clinical (unspecified phase) |
0.7485 | Intermediate Similarity | NPD6168 | Clinical (unspecified phase) |
0.7485 | Intermediate Similarity | NPD6166 | Phase 2 |
0.7483 | Intermediate Similarity | NPD6398 | Clinical (unspecified phase) |
0.7466 | Intermediate Similarity | NPD4060 | Phase 1 |
0.7462 | Intermediate Similarity | NPD9697 | Approved |
0.7451 | Intermediate Similarity | NPD6799 | Approved |
0.745 | Intermediate Similarity | NPD2935 | Discontinued |
0.7448 | Intermediate Similarity | NPD1296 | Phase 2 |
0.7447 | Intermediate Similarity | NPD2983 | Phase 2 |
0.7447 | Intermediate Similarity | NPD2982 | Phase 2 |
0.7434 | Intermediate Similarity | NPD6190 | Approved |
0.7431 | Intermediate Similarity | NPD4908 | Phase 1 |
0.7429 | Intermediate Similarity | NPD1091 | Approved |
0.741 | Intermediate Similarity | NPD7074 | Phase 3 |
0.7391 | Intermediate Similarity | NPD6234 | Discontinued |
0.7376 | Intermediate Similarity | NPD9717 | Approved |
0.7376 | Intermediate Similarity | NPD9269 | Phase 2 |
0.7376 | Intermediate Similarity | NPD2981 | Phase 2 |
0.7365 | Intermediate Similarity | NPD7993 | Clinical (unspecified phase) |
0.7365 | Intermediate Similarity | NPD6797 | Phase 2 |
0.7362 | Intermediate Similarity | NPD6232 | Discontinued |
0.7361 | Intermediate Similarity | NPD9494 | Approved |
0.7348 | Intermediate Similarity | NPD1358 | Approved |
0.7347 | Intermediate Similarity | NPD1558 | Phase 1 |
0.7343 | Intermediate Similarity | NPD1203 | Approved |
0.7338 | Intermediate Similarity | NPD4357 | Discontinued |
0.7329 | Intermediate Similarity | NPD7075 | Discontinued |
0.7329 | Intermediate Similarity | NPD4907 | Clinical (unspecified phase) |
0.7324 | Intermediate Similarity | NPD4749 | Approved |
0.7321 | Intermediate Similarity | NPD7251 | Discontinued |
0.7319 | Intermediate Similarity | NPD5536 | Phase 2 |
0.7301 | Intermediate Similarity | NPD7199 | Phase 2 |
0.7301 | Intermediate Similarity | NPD1247 | Approved |
0.7299 | Intermediate Similarity | NPD6671 | Approved |
0.729 | Intermediate Similarity | NPD4378 | Clinical (unspecified phase) |
0.7286 | Intermediate Similarity | NPD1778 | Approved |
0.7278 | Intermediate Similarity | NPD7808 | Phase 3 |
0.7267 | Intermediate Similarity | NPD1510 | Phase 2 |
0.7267 | Intermediate Similarity | NPD3748 | Approved |
0.7255 | Intermediate Similarity | NPD1878 | Clinical (unspecified phase) |
0.725 | Intermediate Similarity | NPD7096 | Clinical (unspecified phase) |
0.7241 | Intermediate Similarity | NPD2861 | Phase 2 |
0.7239 | Intermediate Similarity | NPD5494 | Approved |
0.7237 | Intermediate Similarity | NPD1549 | Phase 2 |
0.723 | Intermediate Similarity | NPD1240 | Approved |
0.7229 | Intermediate Similarity | NPD7473 | Discontinued |
0.7226 | Intermediate Similarity | NPD6143 | Clinical (unspecified phase) |
0.7222 | Intermediate Similarity | NPD2797 | Approved |
0.7222 | Intermediate Similarity | NPD4381 | Clinical (unspecified phase) |
0.7218 | Intermediate Similarity | NPD290 | Approved |
0.7212 | Intermediate Similarity | NPD7184 | Clinical (unspecified phase) |
0.7211 | Intermediate Similarity | NPD411 | Approved |
0.7197 | Intermediate Similarity | NPD6980 | Clinical (unspecified phase) |
0.7197 | Intermediate Similarity | NPD5403 | Approved |
0.7188 | Intermediate Similarity | NPD6801 | Discontinued |
0.7188 | Intermediate Similarity | NPD37 | Approved |
0.7183 | Intermediate Similarity | NPD1535 | Discovery |
0.7183 | Intermediate Similarity | NPD1611 | Approved |
0.7181 | Intermediate Similarity | NPD1933 | Approved |
0.7181 | Intermediate Similarity | NPD4340 | Discontinued |
0.7179 | Intermediate Similarity | NPD5401 | Approved |
0.7171 | Intermediate Similarity | NPD1550 | Clinical (unspecified phase) |
0.7171 | Intermediate Similarity | NPD1552 | Clinical (unspecified phase) |
0.717 | Intermediate Similarity | NPD4380 | Phase 2 |
0.717 | Intermediate Similarity | NPD6599 | Discontinued |
0.7163 | Intermediate Similarity | NPD4626 | Approved |
0.7162 | Intermediate Similarity | NPD6233 | Phase 2 |
0.716 | Intermediate Similarity | NPD4966 | Approved |
0.716 | Intermediate Similarity | NPD4965 | Approved |
0.716 | Intermediate Similarity | NPD4967 | Phase 2 |
0.7152 | Intermediate Similarity | NPD3687 | Approved |
0.7152 | Intermediate Similarity | NPD3686 | Approved |
0.7143 | Intermediate Similarity | NPD4625 | Phase 3 |
0.7143 | Intermediate Similarity | NPD968 | Approved |
0.7143 | Intermediate Similarity | NPD7819 | Suspended |
0.7143 | Intermediate Similarity | NPD4628 | Phase 3 |
0.7134 | Intermediate Similarity | NPD7314 | Clinical (unspecified phase) |
0.7133 | Intermediate Similarity | NPD1481 | Phase 2 |
0.7133 | Intermediate Similarity | NPD1607 | Approved |
0.7114 | Intermediate Similarity | NPD943 | Approved |
0.7097 | Intermediate Similarity | NPD2219 | Phase 1 |
0.7095 | Intermediate Similarity | NPD6410 | Clinical (unspecified phase) |
0.7095 | Intermediate Similarity | NPD3268 | Approved |
0.7092 | Intermediate Similarity | NPD9268 | Approved |
0.7089 | Intermediate Similarity | NPD920 | Approved |
0.7083 | Intermediate Similarity | NPD7228 | Approved |
0.7078 | Intermediate Similarity | NPD1243 | Approved |
0.7067 | Intermediate Similarity | NPD1899 | Clinical (unspecified phase) |
0.7063 | Intermediate Similarity | NPD4678 | Approved |
0.7063 | Intermediate Similarity | NPD3705 | Approved |
0.7063 | Intermediate Similarity | NPD4675 | Approved |
0.7059 | Intermediate Similarity | NPD3540 | Phase 1 |
0.7055 | Intermediate Similarity | NPD7768 | Phase 2 |
0.7039 | Intermediate Similarity | NPD4308 | Phase 3 |
0.703 | Intermediate Similarity | NPD5677 | Discontinued |
0.7029 | Intermediate Similarity | NPD5283 | Phase 1 |
0.7027 | Intermediate Similarity | NPD7095 | Approved |
0.7021 | Intermediate Similarity | NPD9545 | Approved |
0.7019 | Intermediate Similarity | NPD7411 | Suspended |
0.7018 | Intermediate Similarity | NPD6559 | Discontinued |
0.7015 | Intermediate Similarity | NPD3134 | Approved |
0.7014 | Intermediate Similarity | NPD1608 | Approved |
0.6994 | Remote Similarity | NPD5353 | Approved |
0.6993 | Remote Similarity | NPD2796 | Approved |
0.6993 | Remote Similarity | NPD3539 | Phase 1 |
0.6988 | Remote Similarity | NPD8127 | Discontinued |
0.698 | Remote Similarity | NPD6798 | Discontinued |
0.6972 | Remote Similarity | NPD1357 | Approved |
0.6972 | Remote Similarity | NPD5691 | Approved |
0.6968 | Remote Similarity | NPD7421 | Clinical (unspecified phase) |
0.6962 | Remote Similarity | NPD2534 | Approved |
0.6962 | Remote Similarity | NPD7410 | Clinical (unspecified phase) |
0.6962 | Remote Similarity | NPD2532 | Approved |
0.6962 | Remote Similarity | NPD642 | Clinical (unspecified phase) |
0.6962 | Remote Similarity | NPD2533 | Approved |
0.6957 | Remote Similarity | NPD5535 | Approved |
0.6954 | Remote Similarity | NPD6355 | Discontinued |
0.6954 | Remote Similarity | NPD8055 | Clinical (unspecified phase) |
0.6948 | Remote Similarity | NPD5763 | Approved |
0.6948 | Remote Similarity | NPD5762 | Approved |
0.6943 | Remote Similarity | NPD643 | Clinical (unspecified phase) |
0.6939 | Remote Similarity | NPD1019 | Discontinued |
0.6932 | Remote Similarity | NPD8397 | Clinical (unspecified phase) |
0.6928 | Remote Similarity | NPD651 | Clinical (unspecified phase) |
0.6923 | Remote Similarity | NPD4109 | Clinical (unspecified phase) |
0.6923 | Remote Similarity | NPD4110 | Phase 3 |
0.6919 | Remote Similarity | NPD7685 | Pre-registration |
0.6914 | Remote Similarity | NPD5090 | Approved |
0.6914 | Remote Similarity | NPD5089 | Approved |
0.6912 | Remote Similarity | NPD2684 | Approved |
0.6909 | Remote Similarity | NPD3749 | Approved |
0.6908 | Remote Similarity | NPD6653 | Approved |
0.6903 | Remote Similarity | NPD2424 | Discontinued |
0.6899 | Remote Similarity | NPD5297 | Approved |
0.6894 | Remote Similarity | NPD3111 | Phase 1 |
0.6894 | Remote Similarity | NPD1242 | Phase 1 |
0.6883 | Remote Similarity | NPD6100 | Approved |
0.6883 | Remote Similarity | NPD6099 | Approved |
0.6882 | Remote Similarity | NPD3751 | Discontinued |
0.6879 | Remote Similarity | NPD9493 | Approved |
0.6871 | Remote Similarity | NPD3266 | Approved |
0.6871 | Remote Similarity | NPD3267 | Approved |
0.6867 | Remote Similarity | NPD1048 | Approved |
0.6859 | Remote Similarity | NPD6674 | Discontinued |
0.6846 | Remote Similarity | NPD6832 | Phase 2 |
0.6842 | Remote Similarity | NPD291 | Approved |
0.6842 | Remote Similarity | NPD846 | Approved |
0.6842 | Remote Similarity | NPD7804 | Clinical (unspecified phase) |
0.6842 | Remote Similarity | NPD940 | Approved |
0.6839 | Remote Similarity | NPD1375 | Discontinued |
0.6835 | Remote Similarity | NPD7843 | Approved |
0.6824 | Remote Similarity | NPD6917 | Clinical (unspecified phase) |
0.6818 | Remote Similarity | NPD7033 | Discontinued |
0.681 | Remote Similarity | NPD7615 | Clinical (unspecified phase) |
0.6809 | Remote Similarity | NPD7157 | Approved |
0.6807 | Remote Similarity | NPD6971 | Discontinued |
Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.