NPASS Compound

Natural Product: NPC481417

Natural Product ID	NPC481417
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	FYUIDFGRAOPZPR-HBRJZHEJSA-N
IUPAC Name	n.a.
Synonyms
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	n.a.
PubChem CID	n.a.
Chemical Classification	CHEMONTID:0000000 [Organic compounds]

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 95101 0 0 0 0 0 0 0 0999 V2000 7.6712 -2.9194 -0.8183 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5233 -3.9047 -0.7462 C 0 0 2 0 0 0 0 0 0 0 0 0 5.4804 -3.4789 -1.7132 C 0 0 0 0 0 0 0 0 0 0 0 0 4.2714 -2.8415 -1.1118 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4375 -2.2336 0.2190 C 0 0 1 0 0 0 0 0 0 0 0 0 4.0815 -0.7339 0.2355 C 0 0 1 0 0 0 0 0 0 0 0 0 4.8341 0.0323 -0.7949 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6133 -0.8217 0.0199 C 0 0 1 0 0 0 0 0 0 0 0 0 2.2840 -2.0912 0.8221 C 0 0 2 0 0 0 0 0 0 0 0 0 1.5554 -1.4873 2.0404 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7124 -0.5335 1.3148 C 0 0 1 0 0 0 0 0 0 0 0 0 -0.1475 0.4269 1.9644 C 0 0 2 0 0 0 0 0 0 0 0 0 -0.9256 0.0338 3.1612 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5351 1.3519 3.6734 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.4972 1.8314 2.6652 C 0 0 1 0 0 0 0 0 0 0 0 0 -3.1667 3.1185 3.0920 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.1065 3.6896 2.0958 C 0 0 2 0 0 0 0 0 0 0 0 0 -3.7700 3.4869 0.6605 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.2507 2.0785 0.4250 C 0 0 2 0 0 0 0 0 0 0 0 0 -1.9850 1.9894 1.2558 C 0 0 1 0 0 0 0 0 0 0 0 0 -1.1896 3.2697 1.0984 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.1189 0.8525 0.8429 C 0 0 1 0 0 0 0 0 0 0 0 0 -0.4334 0.9868 -0.4523 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0590 1.1163 -0.4301 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7781 0.2837 0.5601 C 0 0 2 0 0 0 0 0 0 0 0 0 2.5208 1.2145 1.5021 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.1367 1.7508 -0.8837 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.0313 0.7350 -1.2817 C 0 0 1 0 0 0 0 0 0 0 0 0 -4.9016 1.2642 -2.3918 C 0 0 1 0 0 0 0 0 0 0 0 0 -4.6631 0.5679 -3.7059 C 0 0 2 0 0 0 0 0 0 0 0 0 -4.6688 -0.9213 -3.5305 C 0 0 2 0 0 0 0 0 0 0 0 0 -4.0093 -1.3644 -2.2445 C 0 0 1 0 0 0 0 0 0 0 0 0 -3.0389 -2.4781 -2.5902 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.2949 -0.3605 -1.6352 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.0636 -1.4890 -4.6594 O 0 0 0 0 0 0 0 0 0 0 0 0 -3.5149 1.0123 -4.3547 O 0 0 0 0 0 0 0 0 0 0 0 0 -6.2310 1.0758 -2.0390 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.1475 5.0859 2.3166 O 0 0 0 0 0 0 0 0 0 0 0 0 3.4639 -2.6888 1.1421 O 0 0 0 0 0 0 0 0 0 0 0 0 5.6605 -2.4446 0.8317 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9577 -3.8028 0.6667 C 0 0 0 0 0 0 0 0 0 0 0 0 7.7626 -2.4775 -1.8370 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5042 -2.1083 -0.0840 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6009 -3.4495 -0.5005 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8867 -4.9355 -0.9450 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9307 -2.8350 -2.5032 H 0 0 0 0 0 0 0 0 0 0 0 0 5.1344 -4.3984 -2.2722 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4155 -3.5773 -1.0509 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9219 -2.0709 -1.8351 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3541 -0.4337 1.2888 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3536 -0.6600 -1.4915 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6477 0.6713 -0.3608 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1798 0.6882 -1.4290 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4170 -0.9608 -1.0507 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5802 -2.7128 0.2564 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2518 -1.1050 2.7822 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9546 -2.3113 2.5244 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2099 -1.1190 0.4843 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3930 1.3766 2.2293 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.2383 -0.3784 3.9296 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.7344 -0.6687 2.8839 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.7154 2.0467 3.9054 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.0673 1.0941 4.5889 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.3339 1.0705 2.6169 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.4208 3.8614 3.4980 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.7779 2.8442 4.0034 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.1643 3.3525 2.2545 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.0958 4.2388 0.2240 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.7167 3.5533 0.0576 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.0532 1.4154 0.8667 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.1605 3.1624 1.4364 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.6340 4.1262 1.6385 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.1775 3.5753 0.0158 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.8125 -0.0434 0.7779 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.8103 1.8665 -1.0397 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.6467 0.1089 -1.1350 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4577 0.8259 -1.4493 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3232 2.1943 -0.3409 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5575 1.4166 1.0994 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0576 2.2480 1.4660 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5194 0.8987 2.5430 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.6306 0.4500 -0.3806 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.7596 2.3549 -2.5764 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.5202 0.8266 -4.3798 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.7049 -1.3184 -3.5127 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.7562 -1.7900 -1.5202 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.1124 -2.0063 -2.9776 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.7482 -3.0270 -1.6633 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.4476 -3.1608 -3.3640 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.5076 -2.3345 -4.9253 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.8584 0.2487 -4.3272 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.6183 1.9169 -1.7097 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.9400 5.3537 2.8363 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6712 -4.1780 1.4136 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0013 -4.3855 0.6584 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 1 0 4 5 1 0 5 6 1 0 6 7 1 0 6 8 1 0 8 9 1 0 9 10 1 0 10 11 1 0 11 12 1 0 12 13 1 0 13 14 1 0 14 15 1 0 15 16 1 0 16 17 1 0 17 18 1 0 18 19 1 0 19 20 1 0 20 21 1 1 20 22 1 0 22 23 1 0 23 24 1 0 24 25 1 0 25 26 1 1 19 27 1 0 27 28 1 0 28 29 1 0 29 30 1 0 30 31 1 0 31 32 1 0 32 33 1 0 32 34 1 0 31 35 1 0 30 36 1 0 29 37 1 0 17 38 1 0 9 39 1 0 5 40 1 1 40 41 1 0 41 2 1 0 39 5 1 0 25 8 1 0 34 28 1 0 25 11 1 0 22 12 1 0 20 15 1 0 1 42 1 0 1 43 1 0 1 44 1 0 2 45 1 6 3 46 1 0 3 47 1 0 4 48 1 0 4 49 1 0 6 50 1 1 7 51 1 0 7 52 1 0 7 53 1 0 8 54 1 6 9 55 1 6 10 56 1 0 10 57 1 0 11 58 1 6 12 59 1 1 13 60 1 0 13 61 1 0 14 62 1 0 14 63 1 0 15 64 1 6 16 65 1 0 16 66 1 0 17 67 1 6 18 68 1 0 18 69 1 0 19 70 1 1 21 71 1 0 21 72 1 0 21 73 1 0 22 74 1 6 23 75 1 0 23 76 1 0 24 77 1 0 24 78 1 0 26 79 1 0 26 80 1 0 26 81 1 0 28 82 1 1 29 83 1 6 30 84 1 6 31 85 1 1 32 86 1 1 33 87 1 0 33 88 1 0 33 89 1 0 35 90 1 0 36 91 1 0 37 92 1 0 38 93 1 0 41 94 1 0 41 95 1 0 M END

Standard InCHIKey	FYUIDFGRAOPZPR-HBRJZHEJSA-N
Standard InCHI	InChI=1S/C33H54O8/c1-16-8-11-33(38-15-16)17(2)26-24(41-33)14-23-21-7-6-19-12-20(34)13-25(32(19,5)22(21)9-10-31(23,26)4)40-30-29(37)28(36)27(35)18(3)39-30/h16-30,34-37H,6-15H2,1-5H3/t16-,17+,18-,19+,20-,21-,22+,23+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33+/m1/s1
SMILES	C[C@@H]1CC[C@]2([C@@H](C)[C@H]3[C@H](C[C@H]4[C@@H]5CC[C@H]6C[C@H](C[C@H]([C@]6(C)[C@H]5CC[C@]34C)O[C@H]3[C@@H]([C@H]([C@H]([C@@H](C)O3)O)O)O)O)O2)OC1

Calculated Properties

Physi-Chem Properties

MedChem Properties

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

ADMET: Distribution

ADMET: Metabolism

ADMET: Excretion

ADMET: Toxicity

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO40087	Cordyline manners-suttoniae	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31596585]
NPO40087	Cordyline manners-suttoniae	Species	Asparagaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
MBC	4
IC50	2
Ratio IC50	1

Activity Type	# Activity
Cell line	2
Organism	4
Others	1

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT3190	Cell line	NHDF	Homo sapiens	IC50	=	4300.0	nM	PMID[31596585]
NPT941	Cell line	HaCaT	Homo sapiens	IC50	=	18200.0	nM	PMID[31596585]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MBC	=	21.6	uM	PMID[31596585]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	MBC	=	43.2	uM	PMID[31596585]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	3.0	n.a.	PMID[31596585]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC481417 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	26458
0.1-0.2	21022
0.2-0.3	2032
0.3-0.4	171
0.4-0.5	88
0.5-0.6	53
0.6-0.7	21
0.7-0.8	0
0.8-0.85	3
0.85-0.9	1
0.9-0.95	0
0.95-1	2

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC473774
1.0	High Similarity	NPC481419
0.8784	High Similarity	NPC24960
0.8442	Intermediate Similarity	NPC481424
0.8442	Intermediate Similarity	NPC481422
0.8158	Intermediate Similarity	NPC481418
0.7692	Intermediate Similarity	NPC481420
0.7692	Intermediate Similarity	NPC481421
0.7381	Intermediate Similarity	NPC473616
0.6905	Remote Similarity	NPC481423
0.6875	Remote Similarity	NPC144790
0.6875	Remote Similarity	NPC149400
0.6543	Remote Similarity	NPC473469
0.6512	Remote Similarity	NPC481425
0.6512	Remote Similarity	NPC481426
0.6463	Remote Similarity	NPC204881
0.6444	Remote Similarity	NPC306131
0.6444	Remote Similarity	NPC200802
0.6351	Remote Similarity	NPC248944
0.6351	Remote Similarity	NPC7479
0.6351	Remote Similarity	NPC257296
0.6292	Remote Similarity	NPC477451
0.6222	Remote Similarity	NPC222731
0.618	Remote Similarity	NPC131693
0.618	Remote Similarity	NPC475436
0.617	Remote Similarity	NPC70204
0.6136	Remote Similarity	NPC296936
0.6087	Remote Similarity	NPC19400
0.6023	Remote Similarity	NPC485594
0.6	Remote Similarity	NPC277715
0.5976	Remote Similarity	NPC473830
0.5895	Remote Similarity	NPC485595
0.5895	Remote Similarity	NPC6295
0.5889	Remote Similarity	NPC297348
0.5889	Remote Similarity	NPC325828
0.5889	Remote Similarity	NPC249204
0.5889	Remote Similarity	NPC48339
0.5889	Remote Similarity	NPC177834
0.5889	Remote Similarity	NPC141769
0.5889	Remote Similarity	NPC477547
0.5833	Remote Similarity	NPC195297
0.5824	Remote Similarity	NPC294686
0.5824	Remote Similarity	NPC234352
0.5714	Remote Similarity	NPC227260
0.5686	Remote Similarity	NPC294129
0.5641	Remote Similarity	NPC296734
0.5638	Remote Similarity	NPC206003
0.5638	Remote Similarity	NPC473610
0.5579	Remote Similarity	NPC211354
0.5579	Remote Similarity	NPC107188
0.5532	Remote Similarity	NPC250393
0.5517	Remote Similarity	NPC88962
0.5464	Remote Similarity	NPC107962
0.5408	Remote Similarity	NPC470432
0.5408	Remote Similarity	NPC230507
0.5354	Remote Similarity	NPC475670
0.53	Remote Similarity	NPC113044
0.53	Remote Similarity	NPC283829
0.53	Remote Similarity	NPC14704
0.53	Remote Similarity	NPC160426
0.53	Remote Similarity	NPC161676
0.5294	Remote Similarity	NPC475574
0.5269	Remote Similarity	NPC181845
0.5248	Remote Similarity	NPC475351
0.5248	Remote Similarity	NPC112274
0.5244	Remote Similarity	NPC481427
0.5208	Remote Similarity	NPC312678
0.5208	Remote Similarity	NPC253268
0.5196	Remote Similarity	NPC473601
0.5192	Remote Similarity	NPC471464
0.519	Remote Similarity	NPC24556
0.5146	Remote Similarity	NPC470433
0.5146	Remote Similarity	NPC46190
0.5146	Remote Similarity	NPC171073
0.5146	Remote Similarity	NPC602423
0.5091	Remote Similarity	NPC83137
0.5062	Remote Similarity	NPC273290
0.5062	Remote Similarity	NPC232044
0.5059	Remote Similarity	NPC161035
0.5059	Remote Similarity	NPC170438
0.5051	Remote Similarity	NPC264101
0.505	Remote Similarity	NPC141433
0.5048	Remote Similarity	NPC300557

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC481417 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	7642
0.1-0.2	1434
0.2-0.3	64
0.3-0.4	6
0.4-0.5	1
0.5-0.6	2
0.6-0.7	1
0.7-0.8	0
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
0.6351	Remote Similarity	NPD6928	Phase 2
0.5889	Remote Similarity	NPD8171	Phase 2
0.51	Remote Similarity	NPD8170	Phase 2

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data