*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.
Organism ID | Organism Name | Taxonomy Level | Family | SuperKingdom | Isolation Part | Collection Location | Collection Time | Reference |
---|
☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Organism ID | NP ID | Organism Material Preparation | Organism Part | NP Quantity (Standard) | NP Quantity (Minimum) | NP Quantity (Maximum) | Quantity Unit | Reference |
---|
☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].
Target ID | Target Type | Target Name | Target Organism | Activity Type | Activity Relation | Value | Unit | Reference |
---|---|---|---|---|---|---|---|---|
NPT612 | Individual Protein | Canalicular multispecific organic anion transporter 1 | Homo sapiens | Activity | = | 142.0 | % | PMID[491542] |
NPT55 | Individual Protein | Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | = | 19905.4 | nM | PMID[491545] |
NPT531 | Individual Protein | Nuclear receptor ROR-gamma | Mus musculus | Potency | = | 10000.0 | nM | PMID[491545] |
NPT61 | Individual Protein | Beta-glucocerebrosidase | Homo sapiens | Potency | n.a. | 17782.8 | nM | PMID[491545] |
NPT152 | Individual Protein | Nuclear factor erythroid 2-related factor 2 | Homo sapiens | Potency | n.a. | 18356.4 | nM | PMID[491550] |
NPT10 | Individual Protein | Geminin | Homo sapiens | Potency | n.a. | 11220.2 | nM | PMID[491550] |
NPT50 | Individual Protein | Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens | Potency | n.a. | 580.5 | nM | PMID[491550] |
NPT11 | Individual Protein | Guanine nucleotide-binding protein G(s), subunit alpha | Homo sapiens | Potency | n.a. | 31622.8 | nM | PMID[491550] |
NPT611 | Cell Line | Hepatocyte | Homo sapiens | CL | = | 5.62 | uL.min-1.(10^6cells)-1 | PMID[491558] |
NPT1249 | Individual Protein | Canalicular multispecific organic anion transporter 2 | Homo sapiens | IC50 | = | 6390.0 | nM | PMID[491566] |
NPT1028 | Individual Protein | Multidrug resistance-associated protein 4 | Homo sapiens | IC50 | = | 64000.0 | nM | PMID[491566] |
NPT109 | Individual Protein | Cytochrome P450 3A4 | Homo sapiens | FC | = | 6.5 | n.a. | PMID[491574] |
NPT110 | Individual Protein | Cytochrome P450 2D6 | Homo sapiens | FC | = | 2.9 | n.a. | PMID[491574] |
NPT212 | Individual Protein | Cytochrome P450 2C9 | Homo sapiens | FC | = | 1.0 | n.a. | PMID[491574] |
NPT3504 | Individual Protein | Aldo-keto-reductase family 1 member C3 | Homo sapiens | IC50 | = | 850.0 | nM | PMID[491580] |
NPT3507 | Individual Protein | Aldo-keto reductase family 1 member C2 | Homo sapiens | IC50 | > | 50000.0 | nM | PMID[491580] |
NPT3505 | Individual Protein | Aldo-keto reductase family 1 member C1 | Homo sapiens | IC50 | = | 6860.0 | nM | PMID[491580] |
NPT152 | Individual Protein | Nuclear factor erythroid 2-related factor 2 | Homo sapiens | Potency | n.a. | 33488.9 | nM | PubChem BioAssay data set |
NPT153 | Individual Protein | Androgen Receptor | Homo sapiens | Potency | n.a. | 5353.8 | nM | PubChem BioAssay data set |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Delta BG | = | -35.0 | % | PMID[491537] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Delta BG | = | -18.0 | % | PMID[491537] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ED50 | = | 0.182 | mg.kg-1 | PMID[491537] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Delta BG | = | -8.0 | % | PMID[491537] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Delta BG | = | -17.0 | % | PMID[491537] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Delta BG | = | -14.0 | % | PMID[491537] |
NPT35 | Others | n.a. | Solubility | = | 12.7 | nM | PMID[491538] | |
NPT605 | Organism | Homo sapiens | Homo sapiens | F | = | 100.0 | % | PMID[491539] |
NPT2 | Others | Unspecified | FC | = | 2.5 | n.a. | PMID[491540] | |
NPT2 | Others | Unspecified | FC | = | 2.03 | n.a. | PMID[491540] | |
NPT2 | Others | Unspecified | Activity | = | 48.14 | uIU/ml | PMID[491540] | |
NPT2 | Others | Unspecified | Activity | = | 5061.2 | disintegrations/minute | PMID[491540] | |
NPT2 | Others | Unspecified | Activity | = | 6365.67 | disintegrations/minute | PMID[491540] | |
NPT2 | Others | Unspecified | Activity | = | 7476.6 | disintegrations/minute | PMID[491540] | |
NPT2 | Others | Unspecified | Activity | = | 8593.72 | disintegrations/minute | PMID[491540] | |
NPT2 | Others | Unspecified | Activity | = | 11068.51 | disintegrations/minute | PMID[491540] | |
NPT2 | Others | Unspecified | Activity | = | 13255.41 | disintegrations/minute | PMID[491540] | |
NPT605 | Organism | Homo sapiens | Homo sapiens | Activity | = | 1.0 | % | PMID[491541] |
NPT605 | Organism | Homo sapiens | Homo sapiens | CL | = | 0.5 | mL.min-1.kg-1 | PMID[491543] |
NPT605 | Organism | Homo sapiens | Homo sapiens | CL_renal | = | 0.0 | mL.min-1.kg-1 | PMID[491543] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Fg | = | 1.02 | n.a. | PMID[491544] |
NPT605 | Organism | Homo sapiens | Homo sapiens | CL_renal | = | 0.002 | mL.min-1.kg-1 | PMID[491544] |
NPT614 | Tissue | Plasma | Rattus norvegicus | Fu | = | 0.005 | n.a. | PMID[491544] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Vdss | = | 0.19 | L.kg-1 | PMID[491544] |
NPT605 | Organism | Homo sapiens | Homo sapiens | CL | = | 0.5 | mL.min-1.kg-1 | PMID[491544] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Fh | = | 0.98 | n.a. | PMID[491544] |
NPT605 | Organism | Homo sapiens | Homo sapiens | F_fraction | = | 1.0 | n.a. | PMID[491544] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Fa | = | 1.0 | n.a. | PMID[491544] |
NPT197 | Protein-Protein Interaction | Menin/Histone-lysine N-methyltransferase MLL | Homo sapiens | Potency | = | 15848.9 | nM | PMID[491545] |
NPT27 | Others | Unspecified | Vdss | = | 0.19 | L.kg-1 | PMID[491546] | |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | Fu | = | 0.005 | n.a. | PMID[491546] |
NPT27 | Others | Unspecified | CL | = | 0.5 | mL.min-1.kg-1 | PMID[491546] | |
NPT27 | Others | Unspecified | MRT | = | 6.3 | hr | PMID[491546] | |
NPT27 | Others | Unspecified | T1/2 | = | 9.95 | hr | PMID[491546] | |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | Composite Activity - Active | = | 0.0 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | Composite Activity - Marginal | = | 0.0 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | Alkaline Phosphatase Increase - Index Value | = | 1.2 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | Alkaline Phosphatase Increase - Number of Reports | < | 4.0 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | SGOT Increase - Index Value | = | 1.2 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | SGOT Increase - Number of Reports | < | 4.0 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | SGPT Increase - Index Value | = | 1.2 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | SGPT Increase - Number of Reports | < | 4.0 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | LDH Increase - Index Value | = | 0.0 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | LDH Increase - Number of Reports | < | 4.0 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | GGT Increase - Index Value | = | 1.2 | n.a. | PMID[491549] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | GGT Increase - Number of Reports | < | 4.0 | n.a. | PMID[491549] |
NPT2 | Others | Unspecified | Potency | n.a. | 11220.2 | nM | PMID[491550] | |
NPT2 | Others | Unspecified | IC50 | = | 100.0 | nM | PMID[491551] | |
NPT2 | Others | Unspecified | Ki | = | 11.0 | nM | PMID[491551] | |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | LTKB_BD DILI severity score | = | 7.0 | n.a. | PMID[491552] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_bilirubinemia | = | 0.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_cholecystitis | = | 0.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_cholelithiasis | = | 0.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_cirrhosis | = | 0.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_elevated liver function tests | = | 0.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_hepatic failure | = | 1.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_hepatic necrosis | = | 0.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_hepatitis | = | 1.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_hepatomegaly | = | 0.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_jaundice | = | 1.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_liver disease | = | 0.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_liver fatty | = | 0.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_liver function tests abnormal | = | 0.0 | n.a. | PMID[491553] |
NPT20596 | PHENOTYPE | Hepatotoxicity | n.a. | HepSE_Combined Scores | = | 3.0 | n.a. | PMID[491553] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | Hepatotoxicity (moderate) | = | 0.0 | n.a. | PMID[491555] |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | Hepatotoxicity (moderate) | = | 0.0 | % | PMID[491555] |
NPT2 | Others | Unspecified | Hepatotoxicity (acute) | = | 2.0 | n.a. | PMID[491555] | |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | Hepatotoxicity (acute) | = | 0.0 | % | PMID[491555] |
NPT2 | Others | Unspecified | Hepatotoxicity (cytolytic) | = | 1.0 | n.a. | PMID[491555] | |
NPT2 | Others | Unspecified | Hepatotoxicity (choleostasis) | = | 1.0 | n.a. | PMID[491555] | |
NPT2 | Others | Unspecified | Hepatotoxicity (severe hepatitis) | = | 0.0 | n.a. | PMID[491555] | |
NPT2 | Others | Unspecified | Hepatotoxicity (chronic liver disease) | = | 0.0 | n.a. | PMID[491555] | |
NPT2 | Others | Unspecified | Hepatotoxicity (cirrhosis) | = | 0.0 | n.a. | PMID[491555] | |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | Hepatotoxicity (granulomatous hepatitis) | = | 0.0 | n.a. | PMID[491555] |
NPT2 | Others | Unspecified | Hepatotoxicity (association with vascular disease) | = | 0.0 | n.a. | PMID[491555] | |
NPT2 | Others | Unspecified | Hepatotoxicity (steatosis) | = | 0.0 | n.a. | PMID[491555] | |
NPT2 | Others | Unspecified | Hepatotoxicity (malignant tumour) | = | 0.0 | n.a. | PMID[491555] | |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | Hepatotoxicity (benign tumour) | = | 0.0 | n.a. | PMID[491555] |
NPT2 | Others | Unspecified | Potency | n.a. | 22387.2 | nM | PMID[491556] | |
NPT27 | Others | Unspecified | CL | n.a. | 23.2 | uL.min-1.(10^6cells)-1 | PMID[491557] | |
NPT35 | Others | n.a. | LogD7.4 | n.a. | 1.73 | n.a. | PMID[491557] | |
NPT27 | Others | Unspecified | CL | = | 5.1 | mL.min-1.kg-1 | PMID[491558] | |
NPT27 | Others | Unspecified | CL | = | 6.17 | uL.min-1.(10^6cells)-1 | PMID[491558] | |
NPT605 | Organism | Homo sapiens | Homo sapiens | CL | = | 0.69 | mL.min-1.kg-1 | PMID[491558] |
NPT27 | Others | Unspecified | Fu | = | 0.14 | n.a. | PMID[491558] | |
NPT20529 | NON-MOLECULAR | NON-PROTEIN TARGET | n.a. | Fu | = | 0.982 | n.a. | PMID[491558] |
NPT35 | Others | n.a. | pKa | = | 6.2 | n.a. | PMID[491558] | |
NPT2 | Others | Unspecified | AC50 | n.a. | 1780.0 | nM | PMID[491559] | |
NPT2 | Others | Unspecified | Ac50 | n.a. | 1.778 | uM | PMID[491559] | |
NPT2 | Others | Unspecified | AC50 | n.a. | 1000.0 | nM | PMID[491559] | |
NPT2 | Others | Unspecified | Ac50 | n.a. | 1.0 | uM | PMID[491559] | |
NPT2 | Others | Unspecified | IC50 | = | 4.06 | nM | PMID[491559] | |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Inhibition | = | 7.86 | % | PMID[491560] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALT | = | 55.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALB | = | 41500.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALP | = | 449.5 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | AST | = | 112.83 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BUN | = | 173.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CO2 | = | 29500000.0 | nM | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHLORIDE | = | 101.0 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHOL | = | 700.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CK | = | 1325.83 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CREAT | = | 1.8 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | GLUC | = | 1715.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LDH | = | 386.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LIPASE | = | 10.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PHOS | = | 115.7 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | POTASSIUM | = | 6.21 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | SODIUM | = | 141.65 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BILI | = | 1.5 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PROT | = | 57500.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | URATE | = | 12.8 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BASO | = | 0.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | EOS | = | 0.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYM | = | 12191.17 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONO | = | 183.17 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTSG | = | 1192.33 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BASOLE | = | 0.0 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | EOSLE | = | 0.0 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | RBC | = | 5510000.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HCT | = | 35.45 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HGB | = | 138200.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | WBC | = | 13570.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYMLE | = | 89.83 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCH | = | 25.1 | pg | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCHC | = | 389800.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCV | = | 64.42 | fL | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONOLE | = | 1.33 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTLE | = | 8.83 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | RBCNUC | = | 0.0 | /100WBC | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PLAT | = | 1118170.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALT | = | 54.5 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALB | = | 42700.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALP | = | 337.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | AST | = | 94.67 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BUN | = | 170.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CO2 | = | 28330000.0 | nM | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHLORIDE | = | 101.5 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHOL | = | 713.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CK | = | 628.17 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CREAT | = | 1.9 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | GLUC | = | 1778.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LDH | = | 500.5 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LIPASE | = | 9.5 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PHOS | = | 123.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | POTASSIUM | = | 5.63 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | SODIUM | = | 143.03 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BILI | = | 2.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PROT | = | 60200.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | URATE | = | 15.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | EOS | = | 138.17 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYM | = | 13283.17 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONO | = | 303.83 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTSG | = | 1308.17 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | EOSLE | = | 1.0 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | RBC | = | 5320000.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HCT | = | 33.8 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HGB | = | 136300.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | WBC | = | 15030.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYMLE | = | 88.33 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCH | = | 25.68 | pg | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCHC | = | 403500.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCV | = | 63.67 | fL | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONOLE | = | 1.83 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PLAT | = | 1097500.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALT | = | 61.67 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALB | = | 42300.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALP | = | 355.67 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | AST | = | 97.67 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BUN | = | 163.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CO2 | = | 24000000.0 | nM | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHLORIDE | = | 103.67 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHOL | = | 813.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CK | = | 1168.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CREAT | = | 1.6 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | GLUC | = | 1503.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LDH | = | 169.33 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PHOS | = | 122.7 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | POTASSIUM | = | 5.69 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | SODIUM | = | 144.2 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BILI | = | 1.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PROT | = | 58300.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | URATE | = | 15.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | EOS | = | 128.33 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYM | = | 12992.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONO | = | 35.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTSG | = | 1711.33 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | RBC | = | 5200000.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HCT | = | 33.43 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HGB | = | 135000.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | WBC | = | 14870.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYMLE | = | 87.0 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCH | = | 26.03 | pg | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCHC | = | 404000.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCV | = | 64.33 | fL | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONOLE | = | 0.33 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTLE | = | 11.67 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PLAT | = | 1286330.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALT | = | 58.33 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALB | = | 44300.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALP | = | 402.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | AST | = | 81.33 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BUN | = | 156.7 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CO2 | = | 31670000.0 | nM | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHLORIDE | = | 101.33 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHOL | = | 750.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CK | = | 241.33 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | GLUC | = | 1540.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LDH | = | 123.67 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PHOS | = | 105.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | POTASSIUM | = | 6.31 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | SODIUM | = | 143.8 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PROT | = | 62300.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | URATE | = | 11.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYM | = | 12890.33 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONO | = | 43.33 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTSG | = | 866.33 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | RBC | = | 5840000.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HCT | = | 36.5 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HGB | = | 146300.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | WBC | = | 13800.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYMLE | = | 93.33 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCH | = | 25.03 | pg | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCHC | = | 401000.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCV | = | 62.43 | fL | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTLE | = | 6.33 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PLAT | = | 1124670.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALT | = | 60.33 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALB | = | 42000.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALP | = | 398.33 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | AST | = | 110.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BUN | = | 166.7 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CO2 | = | 28000000.0 | nM | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHLORIDE | = | 102.67 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHOL | = | 610.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CK | = | 802.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CREAT | = | 1.4 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | GLUC | = | 1656.7 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LDH | = | 190.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LIPASE | = | 10.33 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PHOS | = | 108.7 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | POTASSIUM | = | 5.99 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | SODIUM | = | 143.87 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BILI | = | 1.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PROT | = | 57300.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | URATE | = | 14.7 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYM | = | 11733.33 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONO | = | 88.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTSG | = | 778.67 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | RBC | = | 5590000.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HCT | = | 36.03 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HGB | = | 142300.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | WBC | = | 12600.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYMLE | = | 92.67 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCH | = | 25.47 | pg | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCHC | = | 396000.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONOLE | = | 0.67 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTLE | = | 6.67 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | RBCNUC | = | 0.33 | /100WBC | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PLAT | = | 1148000.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALT | = | 74.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALB | = | 44700.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | ALP | = | 390.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | AST | = | 96.33 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BUN | = | 190.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CO2 | = | 28670000.0 | nM | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CHOL | = | 720.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | CK | = | 380.67 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | GLUC | = | 1323.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LDH | = | 150.33 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LIPASE | = | 8.0 | U.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PHOS | = | 119.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | POTASSIUM | = | 5.72 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | SODIUM | = | 145.67 | mEq.L-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | BILI | = | 2.3 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PROT | = | 63000.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | EOS | = | 80.67 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYM | = | 11006.67 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONO | = | 128.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTSG | = | 1118.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | EOSLE | = | 0.67 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | RBC | = | 5890000.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HCT | = | 36.97 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | HGB | = | 148000.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | WBC | = | 12330.0 | cells.uL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | LYMLE | = | 89.33 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCH | = | 25.13 | pg | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCHC | = | 400700.0 | ug.mL-1 | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MCV | = | 62.73 | fL | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | MONOLE | = | 1.0 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | NEUTLE | = | 9.0 | % | PMID[491561] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | PLAT | = | 1082670.0 | cells.uL-1 | PMID[491561] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 0.103 | ug.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | AUC | = | 338.8 | ng.hr.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | T1/2 | = | 3.1 | hr | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 0.1024 | ug.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | AUC | = | 315.2 | ng.hr.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 0.1032 | ug.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | T1/2 | = | 5.3 | hr | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 0.352 | ug.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 0.308 | ug.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 0.177 | ug.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 0.551 | ug.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | CL/F | = | 52.1 | mL/min | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Tmax | = | 2.4 | hr | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Vd/F | = | 21.8 | L | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 0.591 | ug.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Tmax | = | 2.5 | hr | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | T1/2 | = | 5.0 | hr | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Vd/F | = | 19.8 | L | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | CL/F | = | 48.5 | mL/min | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 0.578 | ug.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 0.309 | ug.mL-1 | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | CL/F | = | 52.7 | mL/min | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | T1/2 | = | 9.2 | hr | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Tmax | = | 2.8 | hr | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Vd/F | = | 37.1 | L | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Vd | = | 8.8 | L | PMID[491562] |
NPT605 | Organism | Homo sapiens | Homo sapiens | CL | = | 47.8 | mL/min | PMID[491562] |
NPT713 | Individual Protein | Bile salt export pump | Homo sapiens | IC50 | = | 15700.0 | nM | PMID[491563] |
NPT713 | Individual Protein | Bile salt export pump | Homo sapiens | IC50 | = | 34000.0 | nM | PMID[491564] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Cmax | = | 1123.0 | nM | PMID[491564] |
NPT713 | Individual Protein | Bile salt export pump | Homo sapiens | IC50 | < | 10000.0 | nM | PMID[491565] |
NPT713 | Individual Protein | Bile salt export pump | Homo sapiens | IC50 | = | 15700.0 | nM | PMID[491566] |
NPT605 | Organism | Homo sapiens | Homo sapiens | AUC | = | 3.395 | uM.hr | PMID[491566] |
NPT605 | Organism | Homo sapiens | Homo sapiens | Css | = | 0.141 | uM | PMID[491566] |
NPT2 | Others | Unspecified | Ratio | = | 0.009 | n.a. | PMID[491566] | |
NPT2 | Others | Unspecified | Ratio | = | 0.022 | n.a. | PMID[491566] | |
NPT2 | Others | Unspecified | Ratio | = | 0.002 | n.a. | PMID[491566] | |
NPT605 | Organism | Homo sapiens | Homo sapiens | DILI_severity_class | = | 7.0 | n.a. | PMID[491567] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Activity | = | 31.89 | % | PMID[491568] |
NPT2 | Others | Unspecified | EC50 | = | 790.0 | nM | PMID[491568] | |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Activity | = | 30.4 | % | PMID[491570] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Activity | = | 27.7 | % | PMID[491570] |
NPT20555 | ORGANISM | SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | Inhibition index | = | 0.04196 | n.a. | PMID[491571] |
NPT20555 | ORGANISM | SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | Inhibition | = | -4.62 | % | PMID[491572] |
NPT20555 | ORGANISM | SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | Hit score | = | 0.2439 | n.a. | PMID[491573] |
NPT20556 | SINGLE PROTEIN | Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Inhibition | = | 8.644 | % | PMID[491575] |
NPT20555 | ORGANISM | SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | Inhibition | = | -0.17 | % | PMID[491576] |
NPT20 | Organism | Candida albicans | Candida albicans | Inhibition | = | 1.98 | % | PMID[491577] |
NPT85 | Organism | Filobasidiella neoformans | Cryptococcus neoformans | Inhibition | = | -2.89 | % | PMID[491577] |
NPT19 | Organism | Escherichia coli | Escherichia coli | Inhibition | = | 1.16 | % | PMID[491577] |
NPT173 | Organism | Klebsiella pneumoniae | Klebsiella pneumoniae | Inhibition | = | 11.97 | % | PMID[491577] |
NPT18 | Organism | Pseudomonas aeruginosa | Pseudomonas aeruginosa | Inhibition | = | 13.41 | % | PMID[491577] |
NPT747 | Organism | Acinetobacter baumannii | Acinetobacter baumannii | Inhibition | = | 22.8 | % | PMID[491577] |
NPT2922 | Organism | Staphylococcus aureus subsp. aureus | Staphylococcus aureus subsp. aureus | Inhibition | = | 15.98 | % | PMID[491577] |
NPT29 | Organism | Rattus norvegicus | Rattus norvegicus | Activity | = | 23.61 | % | PMID[491578] |
NPT20555 | ORGANISM | SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | IC50 | > | 20000.0 | nM | PMID[491579] |
NPT20555 | ORGANISM | SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | IC50 | > | 19952.62 | nM | PMID[491579] |
NPT2 | Others | Unspecified | Potency | n.a. | 21131.7 | nM | PubChem BioAssay data set | |
NPT2 | Others | Unspecified | Potency | n.a. | 11985.6 | nM | PubChem BioAssay data set | |
NPT2 | Others | Unspecified | Potency | n.a. | 2113.2 | nM | PubChem BioAssay data set | |
NPT2 | Others | Unspecified | Potency | n.a. | 6681.9 | nM | PubChem BioAssay data set | |
NPT2 | Others | Unspecified | Potency | n.a. | 3790.2 | nM | PubChem BioAssay data set | |
NPT2 | Others | Unspecified | Potency | n.a. | 9520.5 | nM | PubChem BioAssay data set |
☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.
Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
●  The left chart: Distribution of similarity level between NPC32858 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Natural Product ID |
---|---|---|
1.0 | High Similarity | NPC194857 |
0.7236 | Intermediate Similarity | NPC317400 |
0.6861 | Remote Similarity | NPC470544 |
0.6846 | Remote Similarity | NPC132636 |
0.6812 | Remote Similarity | NPC470545 |
0.6763 | Remote Similarity | NPC470546 |
0.6739 | Remote Similarity | NPC239357 |
0.6713 | Remote Similarity | NPC22746 |
0.6642 | Remote Similarity | NPC476048 |
0.6621 | Remote Similarity | NPC477937 |
0.662 | Remote Similarity | NPC71684 |
0.6617 | Remote Similarity | NPC471447 |
0.6571 | Remote Similarity | NPC476440 |
0.6562 | Remote Similarity | NPC471319 |
0.6562 | Remote Similarity | NPC471320 |
0.6549 | Remote Similarity | NPC200964 |
0.6541 | Remote Similarity | NPC143516 |
0.6496 | Remote Similarity | NPC181390 |
0.6496 | Remote Similarity | NPC475013 |
0.6493 | Remote Similarity | NPC130898 |
0.6493 | Remote Similarity | NPC474973 |
0.6493 | Remote Similarity | NPC45033 |
0.6493 | Remote Similarity | NPC474804 |
0.6486 | Remote Similarity | NPC300315 |
0.6475 | Remote Similarity | NPC33742 |
0.6457 | Remote Similarity | NPC473661 |
0.6454 | Remote Similarity | NPC254088 |
0.6439 | Remote Similarity | NPC329375 |
0.6438 | Remote Similarity | NPC101719 |
0.6433 | Remote Similarity | NPC313850 |
0.6419 | Remote Similarity | NPC111428 |
0.6419 | Remote Similarity | NPC473322 |
0.6418 | Remote Similarity | NPC473418 |
0.6414 | Remote Similarity | NPC6975 |
0.6405 | Remote Similarity | NPC89489 |
0.6403 | Remote Similarity | NPC35850 |
0.6403 | Remote Similarity | NPC276949 |
0.64 | Remote Similarity | NPC325479 |
0.6389 | Remote Similarity | NPC202521 |
0.6376 | Remote Similarity | NPC200589 |
0.637 | Remote Similarity | NPC222466 |
0.6357 | Remote Similarity | NPC246904 |
0.6357 | Remote Similarity | NPC108339 |
0.6333 | Remote Similarity | NPC255447 |
0.6319 | Remote Similarity | NPC476990 |
0.6319 | Remote Similarity | NPC27833 |
0.6306 | Remote Similarity | NPC322878 |
0.6294 | Remote Similarity | NPC220698 |
0.6277 | Remote Similarity | NPC473676 |
0.6235 | Remote Similarity | NPC286551 |
0.6233 | Remote Similarity | NPC252878 |
0.6231 | Remote Similarity | NPC256452 |
0.6225 | Remote Similarity | NPC126458 |
0.6222 | Remote Similarity | NPC275467 |
0.6216 | Remote Similarity | NPC79698 |
0.6197 | Remote Similarity | NPC473573 |
0.619 | Remote Similarity | NPC305602 |
0.619 | Remote Similarity | NPC46427 |
0.619 | Remote Similarity | NPC17497 |
0.6154 | Remote Similarity | NPC315276 |
0.6154 | Remote Similarity | NPC285926 |
0.6154 | Remote Similarity | NPC14672 |
0.6136 | Remote Similarity | NPC472258 |
0.6133 | Remote Similarity | NPC319766 |
0.6125 | Remote Similarity | NPC311658 |
0.6118 | Remote Similarity | NPC130309 |
0.6108 | Remote Similarity | NPC469243 |
0.6104 | Remote Similarity | NPC141050 |
0.6103 | Remote Similarity | NPC469974 |
0.6099 | Remote Similarity | NPC474584 |
0.6093 | Remote Similarity | NPC165726 |
0.6093 | Remote Similarity | NPC213969 |
0.6076 | Remote Similarity | NPC468984 |
0.6065 | Remote Similarity | NPC314835 |
0.6061 | Remote Similarity | NPC25565 |
0.6049 | Remote Similarity | NPC283783 |
0.6039 | Remote Similarity | NPC287401 |
0.6031 | Remote Similarity | NPC71140 |
0.6031 | Remote Similarity | NPC474974 |
0.6015 | Remote Similarity | NPC473501 |
0.6015 | Remote Similarity | NPC475439 |
0.6014 | Remote Similarity | NPC473498 |
0.6012 | Remote Similarity | NPC475544 |
0.6012 | Remote Similarity | NPC154478 |
0.6 | Remote Similarity | NPC473002 |
0.6 | Remote Similarity | NPC223207 |
0.5988 | Remote Similarity | NPC84317 |
0.5988 | Remote Similarity | NPC105717 |
0.5986 | Remote Similarity | NPC302169 |
0.5975 | Remote Similarity | NPC161069 |
0.5974 | Remote Similarity | NPC473962 |
0.5965 | Remote Similarity | NPC471771 |
0.5965 | Remote Similarity | NPC304074 |
0.5965 | Remote Similarity | NPC290755 |
0.5964 | Remote Similarity | NPC473580 |
0.5964 | Remote Similarity | NPC469903 |
0.5963 | Remote Similarity | NPC314114 |
0.5951 | Remote Similarity | NPC13470 |
0.5942 | Remote Similarity | NPC167336 |
0.5938 | Remote Similarity | NPC52748 |
0.5924 | Remote Similarity | NPC43755 |
0.5924 | Remote Similarity | NPC471265 |
0.5924 | Remote Similarity | NPC471264 |
0.5924 | Remote Similarity | NPC127741 |
0.5912 | Remote Similarity | NPC202613 |
0.5909 | Remote Similarity | NPC120251 |
0.5909 | Remote Similarity | NPC7067 |
0.5906 | Remote Similarity | NPC5719 |
0.5906 | Remote Similarity | NPC217804 |
0.5906 | Remote Similarity | NPC210377 |
0.5906 | Remote Similarity | NPC22883 |
0.5901 | Remote Similarity | NPC315266 |
0.5901 | Remote Similarity | NPC478040 |
0.5901 | Remote Similarity | NPC209509 |
0.5899 | Remote Similarity | NPC327481 |
0.5899 | Remote Similarity | NPC472999 |
0.5897 | Remote Similarity | NPC248283 |
0.5893 | Remote Similarity | NPC324850 |
0.5886 | Remote Similarity | NPC98424 |
0.5886 | Remote Similarity | NPC92784 |
0.5886 | Remote Similarity | NPC178662 |
0.5886 | Remote Similarity | NPC470884 |
0.5886 | Remote Similarity | NPC476133 |
0.5886 | Remote Similarity | NPC77992 |
0.5882 | Remote Similarity | NPC73655 |
0.5879 | Remote Similarity | NPC300443 |
0.5873 | Remote Similarity | NPC474088 |
0.5872 | Remote Similarity | NPC15068 |
0.5867 | Remote Similarity | NPC175726 |
0.5867 | Remote Similarity | NPC474082 |
0.5864 | Remote Similarity | NPC262077 |
0.5862 | Remote Similarity | NPC198254 |
0.5862 | Remote Similarity | NPC274198 |
0.5858 | Remote Similarity | NPC62104 |
0.5858 | Remote Similarity | NPC1390 |
0.5849 | Remote Similarity | NPC239762 |
0.5849 | Remote Similarity | NPC163392 |
0.5845 | Remote Similarity | NPC319579 |
0.5843 | Remote Similarity | NPC122590 |
0.5838 | Remote Similarity | NPC63040 |
0.5828 | Remote Similarity | NPC16188 |
0.5828 | Remote Similarity | NPC138775 |
0.5824 | Remote Similarity | NPC473003 |
0.5824 | Remote Similarity | NPC469902 |
0.5823 | Remote Similarity | NPC68865 |
0.5817 | Remote Similarity | NPC105114 |
0.5817 | Remote Similarity | NPC89923 |
0.5817 | Remote Similarity | NPC239990 |
0.5817 | Remote Similarity | NPC71933 |
0.5817 | Remote Similarity | NPC152850 |
0.5813 | Remote Similarity | NPC269398 |
0.5813 | Remote Similarity | NPC263493 |
0.5813 | Remote Similarity | NPC476989 |
0.581 | Remote Similarity | NPC153554 |
0.5802 | Remote Similarity | NPC201244 |
0.5802 | Remote Similarity | NPC477217 |
0.5802 | Remote Similarity | NPC471680 |
0.5796 | Remote Similarity | NPC474473 |
0.5795 | Remote Similarity | NPC475532 |
0.5793 | Remote Similarity | NPC471820 |
0.5793 | Remote Similarity | NPC471821 |
0.5779 | Remote Similarity | NPC313722 |
0.5779 | Remote Similarity | NPC469666 |
0.5776 | Remote Similarity | NPC77905 |
0.5771 | Remote Similarity | NPC276506 |
0.5769 | Remote Similarity | NPC207428 |
0.5765 | Remote Similarity | NPC24617 |
0.5763 | Remote Similarity | NPC165285 |
0.5759 | Remote Similarity | NPC473360 |
0.5758 | Remote Similarity | NPC254798 |
0.5758 | Remote Similarity | NPC2501 |
0.5755 | Remote Similarity | NPC194390 |
0.5755 | Remote Similarity | NPC224610 |
0.5755 | Remote Similarity | NPC88267 |
0.5755 | Remote Similarity | NPC113326 |
0.5752 | Remote Similarity | NPC136453 |
0.575 | Remote Similarity | NPC307357 |
0.575 | Remote Similarity | NPC476259 |
0.575 | Remote Similarity | NPC268841 |
0.575 | Remote Similarity | NPC46098 |
0.5746 | Remote Similarity | NPC161972 |
0.5746 | Remote Similarity | NPC303045 |
0.5745 | Remote Similarity | NPC55529 |
0.5741 | Remote Similarity | NPC476978 |
0.5732 | Remote Similarity | NPC135121 |
0.5731 | Remote Similarity | NPC114806 |
0.5731 | Remote Similarity | NPC471527 |
0.573 | Remote Similarity | NPC196243 |
0.5723 | Remote Similarity | NPC7817 |
0.5723 | Remote Similarity | NPC189116 |
0.5723 | Remote Similarity | NPC475168 |
0.5714 | Remote Similarity | NPC168113 |
0.5714 | Remote Similarity | NPC129486 |
0.5714 | Remote Similarity | NPC469427 |
0.5714 | Remote Similarity | NPC469426 |
0.5714 | Remote Similarity | NPC280022 |
0.5714 | Remote Similarity | NPC231986 |
0.5706 | Remote Similarity | NPC313867 |
0.5706 | Remote Similarity | NPC5620 |
0.5706 | Remote Similarity | NPC326349 |
Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.
●  The left chart: Distribution of similarity level between NPC32858 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).
Similarity Score | Similarity Level | Drug ID | Developmental Stage |
---|---|---|---|
1.0 | High Similarity | NPD6076 | Approved |
1.0 | High Similarity | NPD6075 | Approved |
0.7803 | Intermediate Similarity | NPD1727 | Approved |
0.7426 | Intermediate Similarity | NPD4478 | Clinical (unspecified phase) |
0.7236 | Intermediate Similarity | NPD838 | Approved |
0.7222 | Intermediate Similarity | NPD5272 | Discontinued |
0.7197 | Intermediate Similarity | NPD480 | Approved |
0.7134 | Intermediate Similarity | NPD5840 | Discontinued |
0.7114 | Intermediate Similarity | NPD5341 | Clinical (unspecified phase) |
0.7089 | Intermediate Similarity | NPD6646 | Discontinued |
0.7073 | Intermediate Similarity | NPD837 | Approved |
0.7055 | Intermediate Similarity | NPD5780 | Phase 2 |
0.7054 | Intermediate Similarity | NPD1406 | Approved |
0.7045 | Intermediate Similarity | NPD1746 | Approved |
0.7045 | Intermediate Similarity | NPD1747 | Approved |
0.7013 | Intermediate Similarity | NPD6611 | Clinical (unspecified phase) |
0.6987 | Remote Similarity | NPD7744 | Clinical (unspecified phase) |
0.6939 | Remote Similarity | NPD7622 | Phase 2 |
0.6928 | Remote Similarity | NPD8362 | Clinical (unspecified phase) |
0.6824 | Remote Similarity | NPD7733 | Phase 2 |
0.6824 | Remote Similarity | NPD3908 | Approved |
0.6815 | Remote Similarity | NPD7745 | Clinical (unspecified phase) |
0.6768 | Remote Similarity | NPD6839 | Clinical (unspecified phase) |
0.6761 | Remote Similarity | NPD6041 | Phase 1 |
0.6741 | Remote Similarity | NPD753 | Approved |
0.6733 | Remote Similarity | NPD1045 | Discontinued |
0.6712 | Remote Similarity | NPD6729 | Phase 2 |
0.669 | Remote Similarity | NPD5339 | Clinical (unspecified phase) |
0.6667 | Remote Similarity | NPD4469 | Phase 3 |
0.6603 | Remote Similarity | NPD8290 | Clinical (unspecified phase) |
0.6573 | Remote Similarity | NPD1948 | Approved |
0.6533 | Remote Similarity | NPD4791 | Clinical (unspecified phase) |
0.6525 | Remote Similarity | NPD3675 | Clinical (unspecified phase) |
0.6503 | Remote Similarity | NPD1947 | Approved |
0.6491 | Remote Similarity | NPD5775 | Approved |
0.6491 | Remote Similarity | NPD5774 | Approved |
0.6475 | Remote Similarity | NPD4674 | Clinical (unspecified phase) |
0.6456 | Remote Similarity | NPD3987 | Approved |
0.6456 | Remote Similarity | NPD3988 | Approved |
0.6443 | Remote Similarity | NPD6919 | Clinical (unspecified phase) |
0.6438 | Remote Similarity | NPD2056 | Discontinued |
0.6405 | Remote Similarity | NPD6901 | Phase 3 |
0.6376 | Remote Similarity | NPD7979 | Clinical (unspecified phase) |
0.637 | Remote Similarity | NPD7130 | Phase 3 |
0.6364 | Remote Similarity | NPD7728 | Clinical (unspecified phase) |
0.6357 | Remote Similarity | NPD2543 | Discontinued |
0.6357 | Remote Similarity | NPD2635 | Clinical (unspecified phase) |
0.6354 | Remote Similarity | NPD6834 | Approved |
0.6352 | Remote Similarity | NPD5614 | Approved |
0.6352 | Remote Similarity | NPD5613 | Approved |
0.6351 | Remote Similarity | NPD3588 | Discontinued |
0.6345 | Remote Similarity | NPD2131 | Approved |
0.634 | Remote Similarity | NPD4782 | Clinical (unspecified phase) |
0.6331 | Remote Similarity | NPD7968 | Clinical (unspecified phase) |
0.6325 | Remote Similarity | NPD5093 | Phase 2 |
0.6323 | Remote Similarity | NPD1261 | Approved |
0.6319 | Remote Similarity | NPD7342 | Discontinued |
0.6309 | Remote Similarity | NPD7828 | Discontinued |
0.6306 | Remote Similarity | NPD5432 | Phase 2 |
0.6303 | Remote Similarity | NPD4567 | Approved |
0.6303 | Remote Similarity | NPD4566 | Approved |
0.6291 | Remote Similarity | NPD3632 | Clinical (unspecified phase) |
0.6288 | Remote Similarity | NPD787 | Suspended |
0.6284 | Remote Similarity | NPD3894 | Discontinued |
0.6282 | Remote Similarity | NPD8076 | Discontinued |
0.6282 | Remote Similarity | NPD3126 | Approved |
0.6276 | Remote Similarity | NPD4651 | Clinical (unspecified phase) |
0.627 | Remote Similarity | NPD9186 | Approved |
0.627 | Remote Similarity | NPD9184 | Approved |
0.6267 | Remote Similarity | NPD4125 | Approved |
0.6259 | Remote Similarity | NPD4677 | Discontinued |
0.6258 | Remote Similarity | NPD5301 | Clinical (unspecified phase) |
0.625 | Remote Similarity | NPD6378 | Approved |
0.6243 | Remote Similarity | NPD7065 | Clinical (unspecified phase) |
0.6241 | Remote Similarity | NPD5630 | Phase 1 |
0.6235 | Remote Similarity | NPD8001 | Phase 3 |
0.6234 | Remote Similarity | NPD5004 | Approved |
0.622 | Remote Similarity | NPD4507 | Discontinued |
0.6207 | Remote Similarity | NPD1104 | Approved |
0.6207 | Remote Similarity | NPD5961 | Clinical (unspecified phase) |
0.6197 | Remote Similarity | NPD1323 | Discontinued |
0.6194 | Remote Similarity | NPD4803 | Discontinued |
0.6194 | Remote Similarity | NPD4214 | Discontinued |
0.6178 | Remote Similarity | NPD7720 | Phase 2 |
0.6174 | Remote Similarity | NPD2585 | Clinical (unspecified phase) |
0.6174 | Remote Similarity | NPD3029 | Clinical (unspecified phase) |
0.6154 | Remote Similarity | NPD4158 | Clinical (unspecified phase) |
0.6149 | Remote Similarity | NPD6088 | Approved |
0.6149 | Remote Similarity | NPD7088 | Discontinued |
0.6148 | Remote Similarity | NPD5655 | Clinical (unspecified phase) |
0.6145 | Remote Similarity | NPD4517 | Clinical (unspecified phase) |
0.6141 | Remote Similarity | NPD6201 | Phase 2 |
0.6139 | Remote Similarity | NPD3513 | Phase 3 |
0.6138 | Remote Similarity | NPD4163 | Clinical (unspecified phase) |
0.6127 | Remote Similarity | NPD3551 | Approved |
0.6127 | Remote Similarity | NPD6613 | Clinical (unspecified phase) |
0.6119 | Remote Similarity | NPD1795 | Discontinued |
0.6117 | Remote Similarity | NPD4133 | Approved |
0.6111 | Remote Similarity | NPD3806 | Clinical (unspecified phase) |
0.6107 | Remote Similarity | NPD6792 | Phase 3 |
0.6107 | Remote Similarity | NPD5367 | Discontinued |
0.6103 | Remote Similarity | NPD488 | Approved |
0.6103 | Remote Similarity | NPD489 | Approved |
0.6084 | Remote Similarity | NPD6855 | Clinical (unspecified phase) |
0.6081 | Remote Similarity | NPD2584 | Suspended |
0.6081 | Remote Similarity | NPD6408 | Phase 1 |
0.608 | Remote Similarity | NPD7563 | Clinical (unspecified phase) |
0.6076 | Remote Similarity | NPD2088 | Approved |
0.6076 | Remote Similarity | NPD2087 | Approved |
0.6074 | Remote Similarity | NPD6588 | Clinical (unspecified phase) |
0.6074 | Remote Similarity | NPD7303 | Discontinued |
0.6069 | Remote Similarity | NPD6345 | Approved |
0.6069 | Remote Similarity | NPD6343 | Approved |
0.6069 | Remote Similarity | NPD483 | Approved |
0.6067 | Remote Similarity | NPD6900 | Discontinued |
0.6067 | Remote Similarity | NPD3606 | Clinical (unspecified phase) |
0.6065 | Remote Similarity | NPD8643 | Discontinued |
0.6061 | Remote Similarity | NPD6392 | Approved |
0.6061 | Remote Similarity | NPD2603 | Clinical (unspecified phase) |
0.6058 | Remote Similarity | NPD1765 | Approved |
0.6058 | Remote Similarity | NPD1763 | Approved |
0.6058 | Remote Similarity | NPD1767 | Approved |
0.6058 | Remote Similarity | NPD1761 | Approved |
0.6058 | Remote Similarity | NPD1766 | Approved |
0.6054 | Remote Similarity | NPD5187 | Clinical (unspecified phase) |
0.6053 | Remote Similarity | NPD5263 | Approved |
0.6051 | Remote Similarity | NPD6655 | Clinical (unspecified phase) |
0.6049 | Remote Similarity | NPD7892 | Clinical (unspecified phase) |
0.6045 | Remote Similarity | NPD784 | Discontinued |
0.6045 | Remote Similarity | NPD4737 | Phase 2 |
0.6045 | Remote Similarity | NPD1796 | Phase 3 |
0.6042 | Remote Similarity | NPD1344 | Phase 2 |
0.6042 | Remote Similarity | NPD4660 | Discontinued |
0.6042 | Remote Similarity | NPD7679 | Phase 2 |
0.6037 | Remote Similarity | NPD4090 | Discontinued |
0.6037 | Remote Similarity | NPD6575 | Clinical (unspecified phase) |
0.6029 | Remote Similarity | NPD1396 | Approved |
0.6027 | Remote Similarity | NPD759 | Approved |
0.6026 | Remote Similarity | NPD3608 | Clinical (unspecified phase) |
0.6025 | Remote Similarity | NPD7602 | Clinical (unspecified phase) |
0.6024 | Remote Similarity | NPD5606 | Discontinued |
0.6024 | Remote Similarity | NPD7822 | Phase 1 |
0.6024 | Remote Similarity | NPD7969 | Clinical (unspecified phase) |
0.6014 | Remote Similarity | NPD4706 | Clinical (unspecified phase) |
0.6014 | Remote Similarity | NPD7062 | Discontinued |
0.6013 | Remote Similarity | NPD5782 | Phase 3 |
0.6012 | Remote Similarity | NPD5002 | Discontinued |
0.6012 | Remote Similarity | NPD4939 | Clinical (unspecified phase) |
0.6 | Remote Similarity | NPD6360 | Discontinued |
0.6 | Remote Similarity | NPD6391 | Approved |
0.6 | Remote Similarity | NPD6623 | Phase 3 |
0.6 | Remote Similarity | NPD6240 | Phase 3 |
0.6 | Remote Similarity | NPD7579 | Clinical (unspecified phase) |
0.6 | Remote Similarity | NPD4063 | Clinical (unspecified phase) |
0.6 | Remote Similarity | NPD8022 | Clinical (unspecified phase) |
0.6 | Remote Similarity | NPD3581 | Discontinued |
0.6 | Remote Similarity | NPD7836 | Clinical (unspecified phase) |
0.5988 | Remote Similarity | NPD5839 | Clinical (unspecified phase) |
0.5988 | Remote Similarity | NPD6396 | Clinical (unspecified phase) |
0.5988 | Remote Similarity | NPD6395 | Phase 2 |
0.5987 | Remote Similarity | NPD4705 | Clinical (unspecified phase) |
0.5987 | Remote Similarity | NPD3626 | Phase 3 |
0.5987 | Remote Similarity | NPD1781 | Discontinued |
0.5986 | Remote Similarity | NPD2810 | Discontinued |
0.5985 | Remote Similarity | NPD1028 | Approved |
0.5985 | Remote Similarity | NPD1026 | Approved |
0.5975 | Remote Similarity | NPD1938 | Clinical (unspecified phase) |
0.5975 | Remote Similarity | NPD4461 | Discontinued |
0.5975 | Remote Similarity | NPD2022 | Approved |
0.5974 | Remote Similarity | NPD7908 | Discontinued |
0.5974 | Remote Similarity | NPD5581 | Approved |
0.5973 | Remote Similarity | NPD3072 | Approved |
0.5973 | Remote Similarity | NPD3071 | Approved |
0.5973 | Remote Similarity | NPD3073 | Approved |
0.597 | Remote Similarity | NPD1724 | Approved |
0.597 | Remote Similarity | NPD466 | Approved |
0.5965 | Remote Similarity | NPD3850 | Clinical (unspecified phase) |
0.5962 | Remote Similarity | NPD4757 | Clinical (unspecified phase) |
0.596 | Remote Similarity | NPD5653 | Discontinued |
0.5957 | Remote Similarity | NPD2583 | Phase 2 |
0.5956 | Remote Similarity | NPD813 | Approved |
0.5954 | Remote Similarity | NPD4650 | Approved |
0.5952 | Remote Similarity | NPD6885 | Approved |
0.5952 | Remote Similarity | NPD6886 | Approved |
0.5951 | Remote Similarity | NPD6631 | Clinical (unspecified phase) |
0.5951 | Remote Similarity | NPD2014 | Approved |
0.5951 | Remote Similarity | NPD5570 | Discontinued |
0.5951 | Remote Similarity | NPD2016 | Approved |
0.5951 | Remote Similarity | NPD2013 | Approved |
0.5944 | Remote Similarity | NPD3598 | Phase 3 |
0.5944 | Remote Similarity | NPD5180 | Approved |
0.5944 | Remote Similarity | NPD5179 | Approved |
0.5944 | Remote Similarity | NPD5181 | Approved |
0.5943 | Remote Similarity | NPD2461 | Phase 1 |
0.5942 | Remote Similarity | NPD959 | Discontinued |
0.5942 | Remote Similarity | NPD5717 | Approved |
0.594 | Remote Similarity | NPD157 | Clinical (unspecified phase) |
0.594 | Remote Similarity | NPD2507 | Clinical (unspecified phase) |
0.5935 | Remote Similarity | NPD4680 | Discontinued |
0.5931 | Remote Similarity | NPD6660 | Discontinued |
Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.