Natural Product Target: Cytochrome P450 2D6

Target ID:   NPT110
Target Name:   Cytochrome P450 2D6
Target Type:   Individual Protein
Organism of Target:   Homo sapiens
Target External ID:   Uniprot_ID:[ P10635]

  Biological Activities of Natural Products against the Target

Natural Product ID Natural Product Name # Activity Records
NPC264166 Quinidine 40
NPC294909 Rauwolfia Serpentina 11
NPC471614 Ketoconazole 9
NPC49196 Yohimbine 9
NPC469308 Sb-203580 8
NPC133162 Nortriptyline 8
NPC316906 Loperamide 7
NPC119818 (3R)-6,7-Dimethoxy-3-[(5R)-4-Methoxy-6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl]-3H-2-Benzofuran-1-One 6
NPC179787 Harman 6
NPC313449 Dequalinium 6
NPC473417 Trifluoperazine 5
NPC329708 Quinine 5
NPC194881 n.a. 5
NPC195268 Papaverine 5
NPC308885 Zucapsaicin 5
NPC318591 Propranolol 4
NPC46451 Sanguinarium 4
NPC319645 Procaine 4
NPC148014 n.a. 4
NPC473206 Diphenyleneiodonium 4
NPC149571 Raloxifene 4
NPC136112 (2R)-1-(Propan-2-Ylamino)-3-(2-Prop-2-Enylphenoxy)Propan-2-Ol 4
NPC316797 Diphenhydramine 4
NPC113099 (2S)-2-(Tert-Butylamino)-1-(3-Chlorophenyl)Propan-1-One 4
NPC316896 Escitalopram 4
NPC327613 Carcinine 4
NPC228343 Nordihydroguaiaretic Acid 3
NPC242895 Phloretin 3
NPC330326 Isoniazid 3
NPC188163 (1S)-1-[(3,4-Dimethoxyphenyl)Methyl]-6,7-Dimethoxy-2-Methyl-3,4-Dihydro-1H-Isoquinoline 3
NPC42793 Verapamil 3
NPC215584 Elliptecine 3
NPC20791 Quercetin 3
NPC302950 Hesperetin 3
NPC473432 Amsacrine 3
NPC231163 (-)-Propanolol 3
NPC248573 Cis-Resveratrol 3
NPC110126 Gramine 3
NPC218530 Dihydrocapsaicin 3
NPC306843 Boldine 3
NPC232727 Harmine 3
NPC78540 Chrysin 3
NPC471603 Sb-202190 3
NPC172937 Vitamin B2 3
NPC143168 Embelin 3
NPC328267 Fluoxetine 3
NPC50898 Apigenin 3
NPC116775 Kaempferol 3
NPC226941 Colchicine 3
NPC93882 Nonivamide 2
NPC313618 Oxybenzone 2
NPC96102 Tryptamine 2
NPC208280 Glyburide 2
NPC314002 Acetylserotonin 2
NPC120671 (6R)-6-[(5R)-6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl]-6H-Furo[3,4-G][1,3]Benzodioxol-8-One 2
NPC53069 Berberine 2
NPC16452 Palmitine 2
NPC264293 Khellin 2
NPC123814 Dihydrospingosine 2
NPC320242 Metoprolol 2
NPC212415 Beta-Lapachone 2
NPC125416 Chlorhexidine 2
NPC36836 Nicardipine 2
NPC57565 Dalfampridine 2
NPC320656 Sertraline 2
NPC100079 Chelerythrine 2
NPC37423 [(6As,9R)-7-Methyl-6,6A,8,9-Tetrahydro-4H-Indolo[4,3-Fg]Quinoline-9-Yl]Methanol 2
NPC59907 Hydrocotarnine 2
NPC469949 Clofazimine 2
NPC476464 Chloroquine 2
NPC230805 8-Hydroxy-2-Methyl-1H-Quinazolin-4-One 2
NPC6854 Olvanil 2
NPC190945 Nifedipine 2
NPC476483 Vorinostat 2
NPC35345 [(1S,5R)-8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl] 4-Hydroxy-3-Methoxybenzoate 2
NPC314968 1-Methyl-1-Nitroso-3-[2,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-3-Yl]Urea 2
NPC64576 (4R,4As,7As,12Bs)-4A,9-Dihydroxy-3-Prop-2-Enyl-2,4,5,6,7A,13-Hexahydro-1H-4,12-Methanobenzofuro[3,2-E]Isoquinoline-7-One 2
NPC315257 Spiramide 2
NPC231772 Acacetin 2
NPC249797 (13Ar)-3,10-Dimethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline-2,9-Diol 2
NPC165549 Deguelin 2
NPC322319 (3R)-3-Tetradecanoyloxy-4-(Trimethylazaniumyl)Butanoate 2
NPC7067 Tolazoline 2
NPC138487 n.a. 2
NPC5167 Graveoline 2
NPC169749 Myricetin 2
NPC326651 (3R)-3-Hexadecanoyloxy-4-(Trimethylazaniumyl)Butanoate 2
NPC220765 Serotonin 2
NPC141791 2-Phenylethyl (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoate 2
NPC291389 Harmol 2
NPC196447 (6Ar)-1,10-Dimethoxy-6-Methyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-2,9-Diol 2
NPC43945 Menadione 2
NPC470090 Sp-600125 2
NPC115159 (Z)-1-(2,4-Dihydroxyphenyl)-3-(4-Hydroxyphenyl)Prop-2-En-1-One 2
NPC307963 Melatonin 2
NPC150048 Cinchonine 2
NPC234560 Daidzein 2
NPC68441 Gossypol 2
NPC176127 n.a. 2
NPC33320 Methoxsalen 2
NPC292758 (1R)-2-[(2R,6R)-6-[(2S)-2-Hydroxy-2-Phenylethyl]-1-Methylpiperidin-2-Yl]-1-Phenylethanol 2
NPC316910 Celecoxib 2
NPC254847 Emodin 2
NPC224814 1,5-Bis(4-Hydroxy-3-Methoxyphenyl)-1,4-Pentadien-3-One 2
NPC471615 Pleconaril 2
NPC316981 N-[2-(6-Hydroxy-5-Methoxy-1H-Indol-3-Yl)Ethyl]Acetamide 2
NPC255817 (2Z,4Z)-5-(1,3-Benzodioxol-5-Yl)-1-Piperidin-1-Ylpenta-2,4-Dien-1-One 2
NPC92111 5-Meo-Dmt 2
NPC204717 3-[2-(Methylamino)Ethyl]-1H-Indol-5-Ol 2
NPC116961 Loratadine 2
NPC146373 Anabasine 2
NPC236347 Epinephrine 2
NPC72788 (6S)-6-[(5R)-6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl]-6H-Furo[3,4-G][1,3]Benzodioxol-8-One 2
NPC293757 (8R,8'r)-4-Hydroxycubebinone 1
NPC206819 Agroclavine 1
NPC46358 Quinoline 1
NPC118832 Quinine 1
NPC227622 Erythromycin 1
NPC52464 Trans-Asarone 1
NPC146422 Dopamine 1
NPC236522 (-)-Cubebinin 1
NPC72796 (-)-Cubebininolide 1
NPC257582 Lariciresinol 1
NPC185903 L-Carnosine 1
NPC294249 (1S)-7-Methoxy-1-Methyl-1,2,3,4-Tetrahydroisoquinolin-6-Ol 1
NPC227814 (2R,3S,5R)-2,3-Epoxy-6,9-Humuladien-5-Ol-8-One 1
NPC478085 (3S,4R)-3-(4-hydroxy-3-methoxyphenyl)-3,4-dihydro-2H-chromen-4-ol 1
NPC147000 Pseudoephedrine 1
NPC319333 2-(Carboxymethylsulfanyl)Acetic Acid 1
NPC239312 Baicalein 1
NPC72980 Harmalol 1
NPC185908 (-)-Clusin 1
NPC96286 Osthole 1
NPC294304 Zerumbone Epoxide 1
NPC209560 Formononetin 1
NPC314087 Adamantan-2-Ol 1
NPC73020 Hydrastine 1
NPC187432 Galangin 1
NPC99572 Medioresinol 1
NPC294409 Biochanin 1
NPC210354 (-)-Yatein 1
NPC36491 Simvastatin 1
NPC228785 Mangostin 1
NPC3531 Valproic Acid 1
NPC243635 Sparteine 1
NPC73738 Daphnetin 1
NPC265557 Bruceantin 1
NPC99734 Ethinyl Estradiol 1
NPC229084 (1Z,6Z)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione 1
NPC245244 3-[(2R)-Piperidin-2-Yl]Pyridine 1
NPC74539 Bergapten 1
NPC273330 D-Glutamate 1
NPC189248 Magnosalin 1
NPC43069 Codeine 1
NPC34770 Skimmianine 1
NPC212794 Isoboldine 1
NPC48093 Kaempferol-3-O-(2,3-Di-O-Acetyl-Alpha-L-Rhamnopyranoside) 1
NPC129687 Asarinin 1
NPC230301 Beta-Sitosterol 1
NPC150809 2,4,5-Trimethoxyphenylacetone 1
NPC2989 Warfarin 1
NPC75179 L-754394 1
NPC273657 (-)-Thujaplicatintrimethyl Ether 1
NPC190461 n.a. 1
NPC102008 Atorvastatin 1
NPC296482 Berberine Chloride 1
NPC213216 5,7-Dihydroxy-2-(2-Hydroxyphenyl)Chromen-4-One 1
NPC13768 (R)-Pinocembrin 1
NPC37496 Glabranin 1
NPC59951 Ermanin 1
NPC151004 n.a. 1
NPC321133 Venlafaxine 1
NPC275305 [(6Ar,9R)-7-Methyl-6,6A,8,9-Tetrahydro-4H-Indolo[4,3-Fg]Quinoline-9-Yl]Methanol 1
NPC103342 Isokaempferide 1
NPC230942 Physostigmine 1
NPC158737 Alpha-Methylcubebin 1
NPC40352 Dihydrocubebin 1
NPC76327 Acetaminophen 1
NPC276294 5-Aminopentanoic Acid 1
NPC216496 Kaempferol-3-O-(2-O-Acetyl-Alpha-L-Rhamnopyranoside) 1
NPC109083 Curcumin 1
NPC216921 Zerumbone 1
NPC134764 (-)-Cubebin 1
NPC164778 Shogaol 1
NPC322040 Debrisoquin 1
NPC77040 (7R)-7-Hydroxylariciresinol 1
NPC279121 Luteolin 1
NPC191104 Bergamottin 1
NPC129217 Kaempferol-3-O-2-O-Acetyl-Alpha-L-Rhamnopyranoside 1
NPC303581 n.a. 1
NPC259957 Kaempferol-3-O-(2,4-Di-O-Acetyl-Alpha-L-Rhamnopyranoside) 1
NPC315822 3-(4-Methoxyphenyl)-5-[[4-(4-Methoxyphenyl)-5-Methyl-1,2,4-Triazol-3-Yl]Sulfanylmethyl]-1,2,4-Oxadiazole 1
NPC283949 (8R,8'r,9's)-5-Methoxyclusin 1
NPC104677 Kaempferol-3-O-(2,3,4-Tri-O-Acetyl-Alpha-L-Rhamnopyranoside) 1
NPC111929 Afzelin 1
NPC220221 n.a. 1
NPC159579 Kaempferol-3-O-(4-O-Acetyl-Alpha-L-Rhamnopyranoside) 1
NPC250266 2-(4-Hydroxyphenyl)-7-Methoxychromen-4-One 1
NPC287638 n.a. 1
NPC307050 Isolariciresinol 1
NPC85707 Sl-0101 1
NPC234078 n.a. 1
NPC67978 Allocryptopine 1
NPC251090 5-Methoxytryptophol 1
NPC79129 Methyl (1S,15R,18R,19R,20S)-18-Hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-Dodecahydroyohimban-19-Carboxylate 1
NPC196937 (-)-Dihydroclusin 1
NPC223384 Armeniaspirole A 1
NPC29599 Alpha-Conidendrin 1
NPC84478 Harmaline 1
NPC85488 (+)-Secoisolariciresinol 1
NPC199851 Tetrahydroalstonine 1
NPC299235 (5Alpha,8Alpha)-2-Oxo-1(10),3,7(11)-Guaiatrien-12,8-Olide 1
NPC116632 4',7-Dimethoxy-5-Hydroxygenistein 1
NPC308267 n.a. 1
NPC226547 Ethoxyclusin 1
NPC143649 1-(2,4,5-Trimethoxyphenyl)Propan-1,2-Dione 1
NPC234822 n.a. 1
NPC5851 (7S,8S)-Methoxy-3',7-Epoxy-8,4'-Oxyneoligna-4,9,9'-Triol 1
NPC19890 Hinokinin 1
NPC41719 Karanjin 1
NPC86469 Protopine 1
NPC293454 Carnosic Acid 1
NPC201055 Naloxone 1
NPC144995 (2R,3R,5R)-2,3-Epoxy-6,9-Humuladien-5-Ol-8-One 1
NPC235077 Triamcinolone 1
NPC71755 (5R)-2,6,9-Humulatrien-5-Ol-8-One 1
NPC42300 Taxiresinol 1
NPC293641 (S)-6-Gingerol 1
NPC469812 Ivermectin 1
NPC24019 Oxoglaucine 1
NPC51146 Psoralen 1
NPC317177 Tretinoin 1
NPC256849 Caffeine 1
NPC20322 Aminopyrine 1
NPC329567 Levofloxacin 1

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3. Compound Information: compound related data of all natural products that have available activity against this target;
4. Species Source: species sources that all natural products that have available activity against this target derived from.

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