Structure

Physi-Chem Properties

Molecular Weight:  259.08
Volume:  255.37
LogP:  2.585
LogD:  2.925
LogS:  -3.358
# Rotatable Bonds:  3
TPSA:  53.72
# H-Bond Aceptor:  5
# H-Bond Donor:  0
# Rings:  3
# Heavy Atoms:  5

MedChem Properties

QED Drug-Likeness Score:  0.723
Synthetic Accessibility Score:  2.523
Fsp3:  0.214
Lipinski Rule-of-5:  Accepted
Pfizer Rule:  Accepted
GSK Rule:  Accepted
BMS Rule:  0
Golden Triangle Rule:  Accepted
Chelating Alert:  0
PAINS Alert:  0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:  -4.766
MDCK Permeability:  3.4345328458584845e-05
Pgp-inhibitor:  0.003
Pgp-substrate:  0.001
Human Intestinal Absorption (HIA):  0.017
20% Bioavailability (F20%):  0.002
30% Bioavailability (F30%):  0.001

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):  0.239
Plasma Protein Binding (PPB):  86.6043472290039%
Volume Distribution (VD):  0.413
Pgp-substrate:  9.479057312011719%

ADMET: Metabolism

CYP1A2-inhibitor:  0.963
CYP1A2-substrate:  0.966
CYP2C19-inhibitor:  0.863
CYP2C19-substrate:  0.822
CYP2C9-inhibitor:  0.52
CYP2C9-substrate:  0.866
CYP2D6-inhibitor:  0.486
CYP2D6-substrate:  0.907
CYP3A4-inhibitor:  0.749
CYP3A4-substrate:  0.663

ADMET: Excretion

Clearance (CL):  8.747
Half-life (T1/2):  0.555

ADMET: Toxicity

hERG Blockers:  0.068
Human Hepatotoxicity (H-HT):  0.162
Drug-inuced Liver Injury (DILI):  0.932
AMES Toxicity:  0.635
Rat Oral Acute Toxicity:  0.739
Maximum Recommended Daily Dose:  0.035
Skin Sensitization:  0.449
Carcinogencity:  0.667
Eye Corrosion:  0.003
Eye Irritation:  0.087
Respiratory Toxicity:  0.903

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General Info & Identifiers & Properties  
Structure MOL file  
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Biological Activities  
Similar NPs/Drugs  

  Natural Product: NPC34770

Natural Product ID:  NPC34770
Common Name*:   Skimmianine
IUPAC Name:   4,7,8-trimethoxyfuro[2,3-b]quinoline
Synonyms:   Skimmianine
Standard InCHIKey:  SLSIBLKBHNKZTB-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C14H13NO4/c1-16-10-5-4-8-11(13(10)18-3)15-14-9(6-7-19-14)12(8)17-2/h4-7H,1-3H3
SMILES:  COc1ccc2c(c1OC)nc1c(cco1)c2OC
Synthetic Gene Cluster:   n.a.
ChEMBL Identifier:   CHEMBL21396
PubChem CID:   6760
Chemical Classification**:  
  • CHEMONTID:0000000 [Organic compounds]
    • [CHEMONTID:0000002] Organoheterocyclic compounds
      • [CHEMONTID:0001253] Quinolines and derivatives
        • [CHEMONTID:0002374] Furanoquinolines

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO26992 Sophora leachiana Species Fabaceae Eukaryota n.a. root n.a. DOI[10.1016/0031-9422(90)85209-X]
NPO5852 Litsea glutinosa Species Lauraceae Eukaryota n.a. leaf n.a. DOI[10.1016/S0031-9422(00)88469-1]
NPO5852 Litsea glutinosa Species Lauraceae Eukaryota n.a. stem n.a. DOI[10.1016/S0031-9422(00)88469-1]
NPO26409 Plakortis simplex Species Plakinidae Eukaryota n.a. Caribbean n.a. PMID[10021943]
NPO24038 Casimiroa edulis Species Rutaceae Eukaryota n.a. seed n.a. PMID[10075120]
NPO25892 Tricleocarpa fragilis Species Galaxauraceae Eukaryota n.a. n.a. n.a. PMID[10691711]
NPO11707 Ruta chalepensis Species Rutaceae Eukaryota roots northern Saudi desert n.a. PMID[10924184]
NPO26409 Plakortis simplex Species Plakinidae Eukaryota n.a. Taiwan n.a. PMID[11277748]
NPO17983 Nigrosabulum globosum Species Bionectriaceae Eukaryota n.a. n.a. n.a. PMID[11374942]
NPO10830 Dictamnus dasycarpus Species Rutaceae Eukaryota Root barks n.a. n.a. PMID[11473427]
NPO7344 Spiraea prunifolia Species Rosaceae Eukaryota n.a. n.a. n.a. PMID[11473429]
NPO20244 Melicope semecarpifolia Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[11575945]
NPO6049 Teclea trichocarpa Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[12141852]
NPO26262 Strychnos potatorum Species Loganiaceae Eukaryota n.a. n.a. n.a. PMID[12398531]
NPO3854 Ruta graveolens Species Rutaceae Eukaryota leaves n.a. n.a. PMID[12568545]
NPO29436 Vepris punctata Species Rutaceae Eukaryota wood Madagascar rainforest n.a. PMID[12713408]
NPO12306 Gonospermum canariense Species Asteraceae Eukaryota n.a. n.a. n.a. PMID[12880311]
NPO29436 Vepris punctata Species Rutaceae Eukaryota wood Madagascar Rainforest n.a. PMID[15165160]
NPO340 Orixa japonica Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[15568765]
NPO26409 Plakortis simplex Species Plakinidae Eukaryota n.a. n.a. n.a. PMID[15921424]
NPO9553 Phyllodium pulchellum Species Fabaceae Eukaryota n.a. n.a. n.a. PMID[15921433]
NPO13657 Peperomia pellucida Species Piperaceae Eukaryota n.a. n.a. n.a. PMID[16499324]
NPO23628 Imperata cylindrica Species Poaceae Eukaryota n.a. n.a. n.a. PMID[16499335]
NPO24038 Casimiroa edulis Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[17228877]
NPO10019 Ilex oblonga Species Aquifoliaceae Eukaryota n.a. leaf n.a. PMID[17329884]
NPO13278 Strychnos spinosa Species Loganiaceae Eukaryota Leaves n.a. n.a. PMID[17637068]
NPO31471 Poncirus trifoliata Species Rutaceae Eukaryota n.a. fruit n.a. PMID[17666859]
NPO20244 Melicope semecarpifolia Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[18163582]
NPO10830 Dictamnus dasycarpus Species Rutaceae Eukaryota root bark n.a. n.a. PMID[18198838]
NPO18723 Zanthoxylum avicennae Species Rutaceae Eukaryota stem wood Pakuashan, Changhua County, Taiwan 2006-Jun PMID[18211005]
NPO15233 Balanophora japonica Species Balanophoraceae Eukaryota n.a. n.a. n.a. PMID[18302336]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. rhizome n.a. PMID[18484537]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. root n.a. PMID[18484537]
NPO20206 Oricia suaveolens Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[18950230]
NPO26203 Dysidea villosa Species Dysideidae Eukaryota n.a. Hainan, China n.a. PMID[19091557]
NPO23557 Zanthoxylum ailanthoides Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[19128011]
NPO3854 Ruta graveolens Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[19191562]
NPO17039 Pharbitis nil Species Convolvulaceae Eukaryota Seeds n.a. n.a. PMID[19435339]
NPO27181 Kleinhovia hospita Species Malvaceae Eukaryota n.a. n.a. n.a. PMID[19489592]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota rhizomes n.a. n.a. PMID[19615910]
NPO8211 Artocarpus odoratissimus Species Moraceae Eukaryota n.a. n.a. n.a. PMID[21275386]
NPO5470 Cynoglossum amabile Species Boraginaceae Eukaryota n.a. n.a. n.a. PMID[22432912]
NPO26409 Plakortis simplex Species Plakinidae Eukaryota n.a. n.a. n.a. PMID[23806071]
NPO21771 Citrus trifoliata Species Rutaceae Eukaryota n.a. fruit n.a. PMID[23872723]
NPO5315 Zanthoxylum bungeanum Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[24175626]
NPO2715 Murraya paniculata Species Rutaceae Eukaryota n.a. twig n.a. PMID[24354205]
NPO2715 Murraya paniculata Species Rutaceae Eukaryota n.a. leaf n.a. PMID[24354205]
NPO7213 Toddalia asiatica Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[24597921]
NPO26409 Plakortis simplex Species Plakinidae Eukaryota n.a. China n.a. PMID[25115700]
NPO26298 Zanthoxylum simulans Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[26666037]
NPO2330 Alchornea cordifolia Species Euphorbiaceae Eukaryota n.a. stem n.a. PMID[26724423]
NPO2330 Alchornea cordifolia Species Euphorbiaceae Eukaryota n.a. root n.a. PMID[26724423]
NPO25406 Celastrus monospermus Species Celastraceae Eukaryota n.a. n.a. n.a. PMID[28006915]
NPO3854 Ruta graveolens Species Rutaceae Eukaryota Whole Plants n.a. n.a. PMID[28093914]
NPO7171 Salvia polystachya Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[29135252]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. PMID[29323912]
NPO27181 Kleinhovia hospita Species Malvaceae Eukaryota n.a. n.a. n.a. PMID[30010341]
NPO12970 Aspergillus fischeri Species Aspergillaceae Eukaryota n.a. n.a. n.a. PMID[31920082]
NPO26904 Salvia hypargeia Species Lamiaceae Eukaryota roots n.a. n.a. PMID[3236010]
NPO21771 Citrus trifoliata Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[32996318]
NPO25583 Beta vulgaris Species Chenopodiaceae Eukaryota n.a. n.a. n.a. PMID[33118348]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. rhizome n.a. PMID[731398]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. root n.a. PMID[731398]
NPO23628 Imperata cylindrica Species Poaceae Eukaryota n.a. rhizome n.a. PMID[7714541]
NPO23628 Imperata cylindrica Species Poaceae Eukaryota n.a. n.a. n.a. PMID[7760071]
NPO26298 Zanthoxylum simulans Species Rutaceae Eukaryota n.a. n.a. n.a. PMID[7798955]
NPO23628 Imperata cylindrica Species Poaceae Eukaryota n.a. rhizome n.a. PMID[7798964]
NPO19895 Plectranthus hereroensis Species Lamiaceae Eukaryota Roots n.a. n.a. PMID[7931371]
NPO23628 Imperata cylindrica Species Poaceae Eukaryota n.a. n.a. n.a. PMID[7964801]
NPO10128 Aplysia punctata Species Aplysiidae Eukaryota n.a. n.a. n.a. PMID[9213585]
NPO23356 Ascodesmis sphaerospora Species Ascodesmidaceae Eukaryota n.a. n.a. n.a. PMID[9868168]
NPO25583 Beta vulgaris Species Chenopodiaceae Eukaryota n.a. n.a. Database[FooDB]
NPO25583 Beta vulgaris Species Chenopodiaceae Eukaryota Leaf n.a. n.a. Database[FooDB]
NPO25583 Beta vulgaris Species Chenopodiaceae Eukaryota Root n.a. n.a. Database[FooDB]
NPO4594 Vitellaria paradoxa Species Sapotaceae Eukaryota n.a. n.a. Database[FooDB]
NPO4594 Vitellaria paradoxa Species Sapotaceae Eukaryota n.a. n.a. Database[FooDB]
NPO8698 Zanthoxylum schinifolium Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO25122 Conium maculatum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO5470 Cynoglossum amabile Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO4340 Peucedanum praeruptorum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO27181 Kleinhovia hospita Species Malvaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO3854 Ruta graveolens Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO1070 Matricaria suffruticosa Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO25583 Beta vulgaris Species Chenopodiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO22281 Warburgia salutaris Species Canellaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO2715 Murraya paniculata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO23628 Imperata cylindrica Species Poaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO5315 Zanthoxylum bungeanum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO25008 Skimmia japonica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO2892 Wikstroemia chamaedaphne Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO27527 Artemisia brevifolia Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO23797 Skimmia reevesiana Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO24038 Casimiroa edulis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO24043 Tylophora asthmatica Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO10830 Dictamnus dasycarpus Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO24476 Phellodendron amurense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO15142 Echium plantagineum Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO5131 Scorzonera hispanica Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO29208 Dictamnus albus Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO340 Orixa japonica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO23557 Zanthoxylum ailanthoides Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO19672 Hosta sieboldiana Species Asparagaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO23807 Trollius macropetalus Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO26992 Sophora leachiana Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO9087 Sarcococca vagans Species Buxaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO4120 Ulmus americana Species Ulmaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO31471 Poncirus trifoliata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO7213 Toddalia asiatica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO8642 Lithospermum officinale Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO8471 Angelica taiwaniana Species Apiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO19166 Helianthus niveus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO9031 Euonymus europaeus Species Celastraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO18723 Zanthoxylum avicennae Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO25400 Derris malaccensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO26298 Zanthoxylum simulans Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO24478 Morinda coreia Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO18997 Hernandia sonora Species Hernandiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO13278 Strychnos spinosa Species Loganiaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO6320 Echinosophora koreensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO20244 Melicope semecarpifolia Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO15233 Balanophora japonica Species Balanophoraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO5852 Litsea glutinosa Species Lauraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO9783 Mikania scandens Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO17862 Zanthoxylum planispinum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO22242 Phellodendron chinense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO11707 Ruta chalepensis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO28560 Sarcomelicope glauca Species Rutaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO14163.1 Hesperocyparis goveniana var. abramsiana Varieties Cupressaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO6320 Echinosophora koreensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5315 Zanthoxylum bungeanum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23588 Ursinia anthemoides Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8698 Zanthoxylum schinifolium Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9783 Mikania scandens Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO1070 Matricaria suffruticosa Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25122 Conium maculatum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO24476 Phellodendron amurense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO10098 Glycosmis pseudoracemosa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9087 Sarcococca vagans Species Buxaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO27181 Kleinhovia hospita Species Malvaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19672 Hosta sieboldiana Species Asparagaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8471 Angelica taiwaniana Species Apiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO19166 Helianthus niveus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO22242 Phellodendron chinense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23557 Zanthoxylum ailanthoides Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9069 Persicaria tinctoria Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO24043 Tylophora asthmatica Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8642 Lithospermum officinale Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO9031 Euonymus europaeus Species Celastraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17862 Zanthoxylum planispinum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO11707 Ruta chalepensis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5852 Litsea glutinosa Species Lauraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15142 Echium plantagineum Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO4340 Peucedanum praeruptorum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5131 Scorzonera hispanica Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO18997 Hernandia sonora Species Hernandiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23628 Imperata cylindrica Species Poaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26898 Jacobaea vulgaris Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO340 Orixa japonica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO5470 Cynoglossum amabile Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO18723 Zanthoxylum avicennae Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13313 Talipariti tiliaceum Species Malvaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7171 Salvia polystachya Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO12487 Juniperus horizontalis Species Cupressaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26298 Zanthoxylum simulans Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO2892 Wikstroemia chamaedaphne Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO20244 Melicope semecarpifolia Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23807 Trollius macropetalus Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO7213 Toddalia asiatica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO24478 Morinda coreia Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO28560 Sarcomelicope glauca Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25400 Derris malaccensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO3854 Ruta graveolens Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO15233 Balanophora japonica Species Balanophoraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO10830 Dictamnus dasycarpus Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13278 Strychnos spinosa Species Loganiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO24038 Casimiroa edulis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO4120 Ulmus americana Species Ulmaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25583 Beta vulgaris Species Chenopodiaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO2715 Murraya paniculata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO13657 Peperomia pellucida Species Piperaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO22281 Warburgia salutaris Species Canellaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO29208 Dictamnus albus Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23797 Skimmia reevesiana Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO21771 Citrus trifoliata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26557 Daphne tangutica Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO25008 Skimmia japonica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO23772 Tetradium glabrifolium Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO17039 Pharbitis nil Species Convolvulaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO27527 Artemisia brevifolia Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26447 Cassia singueana Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26992 Sophora leachiana Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO8642 Lithospermum officinale Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO31471 Poncirus trifoliata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO11707 Ruta chalepensis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO23628 Imperata cylindrica Species Poaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO4340 Peucedanum praeruptorum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO24476 Phellodendron amurense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO19672 Hosta sieboldiana Species Asparagaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO5470 Cynoglossum amabile Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO7213 Toddalia asiatica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO26298 Zanthoxylum simulans Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO23807 Trollius macropetalus Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO25008 Skimmia japonica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO8698 Zanthoxylum schinifolium Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO340 Orixa japonica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO25122 Conium maculatum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO18723 Zanthoxylum avicennae Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO26557 Daphne tangutica Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO25400 Derris malaccensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17862 Zanthoxylum planispinum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO9087 Sarcococca vagans Species Buxaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO10830 Dictamnus dasycarpus Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO23797 Skimmia reevesiana Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO3854 Ruta graveolens Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO29208 Dictamnus albus Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO2715 Murraya paniculata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO25583 Beta vulgaris Species Chenopodiaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO5315 Zanthoxylum bungeanum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO9783 Mikania scandens Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO22242 Phellodendron chinense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TCM_Taiwan]
NPO17039 Pharbitis nil Species Convolvulaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO23628 Imperata cylindrica Species Poaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO8698 Zanthoxylum schinifolium Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO10830 Dictamnus dasycarpus Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO26538 Phellodendron chinese Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO24476 Phellodendron amurense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO5315 Zanthoxylum bungeanum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO21771 Citrus trifoliata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO9069 Persicaria tinctoria Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO2715 Murraya paniculata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO4340 Peucedanum praeruptorum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO22242 Phellodendron chinense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[TM-MC]
NPO16801 Cota tinctoria Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15145 Rauvolfia salicifolia Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO29208 Dictamnus albus Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6501 Glycosmis cochinchinensis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3761 Plectosphaerella cucumerina Species Plectosphaerellaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17039 Pharbitis nil Species Convolvulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12277 Dendroctonus pseudotsugae Species Curculionidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11784 Sickingia rubra n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO17231 Pycnarrhena australiana Species Menispermaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9590 Xanthoria aureola Species Teloschistaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7847 Senecio densiflorus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5852 Litsea glutinosa Species Lauraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17492 Amomum reticulatum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7213 Toddalia asiatica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24083.1 Melanelixia fuliginosa subsp. glabratula Subspecies Parmeliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10128 Aplysia punctata Species Aplysiidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24918 Jacobaea cannabifolia Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4895 Coleus esquirolii Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4340 Peucedanum praeruptorum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8067 Pelargonium crispum Species Geraniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6128 Hunteria eburnea Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO617 Vicia balansae Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1040 Ficus conraui Species Moraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17862 Zanthoxylum planispinum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26690 Lactarius subpiperatus Species Lactariidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26729 Aster indicus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO854 Fucus serratus Species Fucaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25583 Beta vulgaris Species Chenopodiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22281 Warburgia salutaris Species Canellaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15142 Echium plantagineum Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14526 Plectranthus caninus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23772 Tetradium glabrifolium Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9414 Tuberolachnus salignus Species Lachnidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7521 Hygrophorus eburneus Species Hygrophoraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9995 Cynara humilis Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10098 Glycosmis pseudoracemosa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3965 Corynanthe pachyceras Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26167 Strychnos cocculoides Species Loganiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17868 Eucryphia glutinosa Species Cunoniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9069 Persicaria tinctoria Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17983 Nigrosabulum globosum Species Bionectriaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21284 Cynoglossum viridiflorum Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25833 Asclepias subulata Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19489 Tylosema esculentum Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO103 Stereocaulon salazinum Species Stereocaulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21771 Citrus trifoliata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24233 Thynnus thynnus Species Tiphiidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2892 Wikstroemia chamaedaphne Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2199 Tecoma pentaphylla Species Bignoniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14947 Lathyrus tingitanus Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24043 Tylophora asthmatica Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25358 Senecio gilliesi Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18873.2 Salmonella enterica subsp. enterica serovar bovismorbificans Subspecies Enterobacteriaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO16266 Didymium bahiense Species Didymiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19680 Haminoea orteai Species Haminoeidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16000 Cetorhinus maximus Species Alopiidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10264 Platonia insignis Species Clusiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24539 Veronica cupressoides Species Plantaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3005 Passiflora morifolia Species Passifloraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26784 Olea capensis Species Oleaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5799 Streptomyces chryseus Species Streptomycetaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO6556 Garcinia intermedia Species Clusiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11475 Vernonia chloropappa Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24079 Eucalyptus laevopinea Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23490 Dalbergia monetaria Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11119 Salta triflora Species Polygonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7028 Sida veronicaefolia Species Malvaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6906 Atalantia wightii Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22890 Eutrochium purpureum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1568 Allium ramosum Species Amaryllidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12367 Diospyros elliptifolia Species Ebenaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26609 Nauclea gambir Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9324 0techis scutatus Species Elapidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO83 Saccharina angustata Species Laminariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13438 Centaurea calcitrapa Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7171 Salvia polystachya Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25201 Aglaia pyramidata Species Meliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13278 Strychnos spinosa Species Loganiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9092 Agapanthus africanus Species Amaryllidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15809 Solenostemon sylvaticus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4120 Ulmus americana Species Ulmaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7841 Solanum transcaucasicum Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14518 Ateleia herbert-smithii Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11707 Ruta chalepensis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO340 Orixa japonica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3560 Trifolium montanum Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13555 Beaucarnea recurvata Species Asparagaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26400 Boronia anemonifolia Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1682 Rhytidoponera metallica Species Formicidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6049 Teclea trichocarpa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9031 Euonymus europaeus Species Celastraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14793 Erica glauca Species Ericaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1329 Esenbeckia hartmanii Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10830 Dictamnus dasycarpus Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25892 Tricleocarpa fragilis Species Galaxauraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1267 Acronychia laurifolia Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24396 Grosvenoria rimbachii n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO26849 Parmelia zollingeri Species Parmeliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8471 Angelica taiwaniana Species Apiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26974 Morella cerifera Species Myricaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26082 Flindersia laevicarpa Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO21954 Streptomyces levoris Species Streptomycetaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO27474 Rhizopus japonicus Species Rhizopodaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23822 Polypodium aureum Species Polypodiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7870 Zanthoxylum piperitum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7650 Salvia munzii Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2715 Murraya paniculata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27181 Kleinhovia hospita Species Malvaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23797 Skimmia reevesiana Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6801 Bellium bellidioides Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9476 Metapenaeus bennettae Species Penaeidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24478 Morinda coreia Species Rubiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26203 Dysidea villosa Species Dysideidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26928 Zanthoxylum capense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12306 Gonospermum canariense Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5470 Cynoglossum amabile Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17624 Spatoglossum pacificum Species Dictyotaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24547 Xanthoria parietina Species Teloschistaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23628 Imperata cylindrica Species Poaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27347 Knautia arvensis Species Caprifoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1109 Corydalis persica Species Papaveraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8642 Lithospermum officinale Species Boraginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18897 Cephalosporium gregatum Species n.a. Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23807 Trollius macropetalus Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26992 Sophora leachiana Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3963 Hortonia floribunda Species Monimiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9783 Mikania scandens Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25714 Solanum spirale Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12233 Diospyros peregrina Species Ebenaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13848 Amomum daniellii Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4594 Vitellaria paradoxa Species Sapotaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7966 Grewia villosa Species Malvaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24038 Casimiroa edulis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14890 Macroclinidium robustum Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12487 Juniperus horizontalis Species Cupressaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20244 Melicope semecarpifolia Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18997 Hernandia sonora Species Hernandiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19672 Hosta sieboldiana Species Asparagaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26728 Calycanthus chinensis Species Calycanthaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4523 Reaumuria hirtella Species Tamaricaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14209 Dysphania graveolens Species Chenopodiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25259 Schrebera swietenoides Species Oleaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO777 Kielmeyera coriacea Species Calophyllaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1467 Wedelia prostrata Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5451 Ageratina saltillensis Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25650 Dacrydium fonkii Species Mytilidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24349 Ceratocystis variospora Species Ceratocystidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8211 Artocarpus odoratissimus Species Moraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13657 Peperomia pellucida Species Piperaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18014 Gracilaria eucheumoides Species Gracilariaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16452 Iochroma coccineum Species Solanaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12658 Melipotis perpendicularis Species 0ctuidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1319 Zanthoxylum culantrillo Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6378 Wilcoxia viperina n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO18723 Zanthoxylum avicennae Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15329 Rhizoplaca baranowii Species Lecanoraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19895 Plectranthus hereroensis Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9814 Lactarius fuliginosus Species Russulaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15500 Aconitum volubile Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23356 Ascodesmis sphaerospora Species Ascodesmidaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15558 Leucas neufliseana Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27582 Shorea affinis Species Dipterocarpaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1100 Croton joufra Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22242 Phellodendron chinense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6320 Echinosophora koreensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16708 Pinus abies Species Pinaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO17513 Lagochilus hirsutissimus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8253 Alexandrium hiranoi Species Gonyaulacaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20059.1 Lactobacillus delbrueckii subsp. bulgaricus Subspecies Lactobacillaceae Bacteria n.a. n.a. n.a. Database[UNPD]
NPO27527 Artemisia brevifolia Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26160 Thielavia terricola Species Chaetomiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12591 Archaster typicus Species Archasteridae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12970 Aspergillus fischeri Species Aspergillaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26298 Zanthoxylum simulans Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26262 Strychnos potatorum Species Loganiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14640 Uresiphita reversalis Species Crambidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23886 Pachysandra axillaris Species Buxaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18402 Tecoma peroba Species Bignoniaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10466 Commiphora kua Species Burseraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15572 Espeletiopsis purpurascens Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5604 Chelonia japonica Species Cheloniidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5315 Zanthoxylum bungeanum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13941 Aeollanthus buchnerianus Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO29436 Vepris punctata Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13435 Propylea quatuordecimpunctata Species Coccinellidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20762 Haplophyllum bucharicum Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16936 Evea brasiliensis n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO6894 Elegia deusta Species Restionaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22061 Siphonaria normalis Species Siphonariidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1833 Erigeron acris Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24476 Phellodendron amurense Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3750 Solidago missouriensis Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26861 Epinetrum cordifolium n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO28636 Vernonia lilacina Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20279 Parmelia damaziana Species Parmeliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9087 Sarcococca vagans Species Buxaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25802 Agave deserti Species Asparagaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25008 Skimmia japonica Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15409 Melicope perspicuinervia Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23482 Vernonia cinerascens Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24201 Cinnamomum massoia Species Lauraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4746 Centaurea arenaria Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8601 Petrosia volcano Species Petrosiidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO10019 Ilex oblonga Species Aquifoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7614 Laurus camphora Species Lauraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9361 Aplophyllum villosum n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO18972 Astropecten indicus Species Astropectinidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26317 Cladosporium phlei Species Cladosporiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1326 Cratystylis conocephala Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16406 Leptospermum recurvum Species Myrtaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO6386 Gutenbergia cordifolia Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1759 Alexandrium excavatum Species Gonyaulacaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23588 Ursinia anthemoides Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5131 Scorzonera hispanica Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26904 Salvia hypargeia Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO28560 Sarcomelicope glauca Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO16032 Xanthoparmelia quintaria Species Parmeliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11430 Inula grantioides Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23557 Zanthoxylum ailanthoides Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO20206 Oricia suaveolens Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO14163.1 Hesperocyparis goveniana var. abramsiana Varieties Cupressaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3659 Limonium bicolor Species Plumbaginaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13647 Calcarisporium thermophilum Species n.a. Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24791 Smyrnium perfoliatum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO27051 Austroplenckia populnea n.a. n.a. n.a. n.a. n.a. n.a. Database[UNPD]
NPO216 Leontodon filii Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8698 Zanthoxylum schinifolium Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7344 Spiraea prunifolia Species Rosaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23398 Caralluma russeliana Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13042 Diospyros abyssinica Species Ebenaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25406 Celastrus monospermus Species Celastraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25122 Conium maculatum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13313 Talipariti tiliaceum Species Malvaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9221 Trachelospermum lucidum Species Apocynaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9553 Phyllodium pulchellum Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2015 Udotea petiolata Species Udoteaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO24280 Helianthus californicus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO15233 Balanophora japonica Species Balanophoraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26789 Tephrosia bidwilli Species Geometridae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1947 Nemopilema nomurai Species Rhizostomatidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO8022 Consolida hohenackeri Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26137 Aplidium conicum Species Polyclinidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11333 Trapa japonica Species Lythraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO5398 Peucedanum oroselinum Species Apiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2999 Coprinellus flocculosus Species Psathyrellaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22899 Phaeotremella fagi Species Phaeotremellaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO3341 Leishmania major Species Trypanosomatidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9989 Cotylelobium scabriusculum Species Dipterocarpaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1070 Matricaria suffruticosa Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26557 Daphne tangutica Species Thymelaeaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO23943 Aconitum chiisanense Species Ranunculaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO22264 Inula salsoloides Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26971 Tetilla japonica Species Tetillidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26447 Cassia singueana Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO2330 Alchornea cordifolia Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25795 Neurolaena macrophylla Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO13526 Medicago hybrida Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO12819 Clitocybe subilludens Species Tricholomataceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26898 Jacobaea vulgaris Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25400 Derris malaccensis Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO1538 Lepechinia hastata Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO19166 Helianthus niveus Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26409 Plakortis simplex Species Plakinidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO4812 Cynometra hankei Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9733 Spongia bilamellata Species Spongiidae Eukaryota n.a. n.a. n.a. Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  NP Quantity Composition/Concentration

Organism ID NP ID Organism Material Preparation Organism Part NP Quantity (Standard) NP Quantity (Minimum) NP Quantity (Maximum) Quantity Unit Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT1212 Cell Line N1E-115 Mus musculus BK = 20.0 % PMID[529466]
NPT1212 Cell Line N1E-115 Mus musculus BNa = 6.0 % PMID[529466]
NPT1213 Individual Protein Voltage-gated potassium channel subunit Kv1.3 Mus musculus BK = 13.0 % PMID[529466]
NPT179 Cell Line A2780 Homo sapiens IC50 = 4.2 ug.mL-1 PMID[529471]
NPT1161 Cell Line CHO Cricetulus griseus Activity = 0.0 % PMID[529472]
NPT1161 Cell Line CHO Cricetulus griseus Activity = 50.0 % PMID[529472]
NPT1161 Cell Line CHO Cricetulus griseus Activity = 61.9 % PMID[529472]
NPT1161 Cell Line CHO Cricetulus griseus Activity = 59.9 % PMID[529472]
NPT1161 Cell Line CHO Cricetulus griseus Activity = 45.0 % PMID[529472]
NPT1161 Cell Line CHO Cricetulus griseus Activity = 10.9 % PMID[529472]
NPT1161 Cell Line CHO Cricetulus griseus Activity = 3.0 % PMID[529472]
NPT81 Cell Line A549 Homo sapiens IC50 > 10000.0 nM PMID[529473]
NPT483 Individual Protein Prelamin-A/C Homo sapiens Potency = 3162.3 nM PMID[529475]
NPT149 Individual Protein Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Homo sapiens Potency = 12589.3 nM PMID[529474]
NPT149 Individual Protein Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Homo sapiens Potency = 12589.3 nM PMID[529475]
NPT48 Individual Protein Lysine-specific demethylase 4D-like Homo sapiens Potency = 12589.3 nM PMID[529475]
NPT48 Individual Protein Lysine-specific demethylase 4D-like Homo sapiens Potency = 28183.8 nM PMID[529476]
NPT48 Individual Protein Lysine-specific demethylase 4D-like Homo sapiens Potency = 14125.4 nM PMID[529474]
NPT210 Individual Protein Thyroid stimulating hormone receptor Homo sapiens Potency = 7943.3 nM PMID[529475]
NPT213 Individual Protein Cytochrome P450 2C19 Homo sapiens Potency = 10000.0 nM PMID[529477]
NPT53 Individual Protein 4'-phosphopantetheinyl transferase ffp Bacillus subtilis Potency = 100000.0 nM PMID[529474]
NPT151 Individual Protein 15-hydroxyprostaglandin dehydrogenase [NAD+] Homo sapiens Potency = 14125.4 nM PMID[529475]
NPT151 Individual Protein 15-hydroxyprostaglandin dehydrogenase [NAD+] Homo sapiens Potency = 14125.4 nM PMID[529474]
NPT149 Individual Protein Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Homo sapiens Potency = 5011.9 nM PMID[529477]
NPT539 Individual Protein Cellular tumor antigen p53 Homo sapiens Potency = 25118.9 nM PMID[529474]
NPT109 Individual Protein Cytochrome P450 3A4 Homo sapiens Potency = 12589.3 nM PMID[529474]
NPT109 Individual Protein Cytochrome P450 3A4 Homo sapiens Potency = 7943.3 nM PMID[529475]
NPT110 Individual Protein Cytochrome P450 2D6 Homo sapiens Potency = 19952.6 nM PMID[529477]
NPT443 Individual Protein Histone acetyltransferase GCN5 Homo sapiens Potency n.a. 25118.9 nM PMID[529476]
NPT64 Individual Protein ATPase family AAA domain-containing protein 5 Homo sapiens Potency n.a. 18348.9 nM PMID[529476]
NPT109 Individual Protein Cytochrome P450 3A4 Homo sapiens AC50 = 7943.28 nM PMID[529475]
NPT208 Individual Protein Cytochrome P450 1A2 Homo sapiens AC50 = 79.43 nM PMID[529475]
NPT484 Individual Protein Luciferin 4-monooxygenase Photinus pyralis Potency n.a. 23934.1 nM PMID[529476]
NPT10 Individual Protein Geminin Homo sapiens Potency n.a. 920.0 nM PMID[529476]
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus Inhibition = 39.26 % PMID[529478]
NPT204 Individual Protein Acetylcholinesterase Homo sapiens IC50 = 8.6 ug.mL-1 PMID[529480]
NPT204 Individual Protein Acetylcholinesterase Homo sapiens Inhibition = 91.3 % PMID[529480]
NPT50 Individual Protein Tyrosyl-DNA phosphodiesterase 1 Homo sapiens Potency n.a. 29092.9 nM PMID[529476]
NPT50 Individual Protein Tyrosyl-DNA phosphodiesterase 1 Homo sapiens Potency n.a. 11885.6 nM PMID[529481]
NPT105 Individual Protein Muscleblind-like protein 1 Homo sapiens Potency n.a. 10000.0 nM PMID[529476]
NPT446 Individual Protein Rap guanine nucleotide exchange factor 3 Homo sapiens Potency n.a. 2818.4 nM PMID[529476]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. IC50 = 19150.0 nM PMID[529467]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. IC50 = 13240.0 nM PMID[529467]
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 47500.0 nM PMID[529468]
NPT485 Organism Plasmodium falciparum (isolate K1 / Thailand) Plasmodium falciparum K1 IC50 = 59000.0 nM PMID[529468]
NPT602 Organism Mycobacterium smegmatis Mycobacterium smegmatis MIC = 100.0 ug.mL-1 PMID[529469]
NPT79 Organism Bacillus subtilis Bacillus subtilis MIC = 100.0 ug.mL-1 PMID[529469]
NPT1208 Organism Leishmania braziliensis Leishmania braziliensis IC90 = 100.0 ug.mL-1 PMID[529470]
NPT580 Organism Trypanosoma cruzi Trypanosoma cruzi IC90 = 100.0 ug.mL-1 PMID[529470]
NPT20529 NON-MOLECULAR NON-PROTEIN TARGET n.a. IC50 = 51300.0 nM PMID[529473]
NPT2 Others Unspecified IC50 = 35500.0 nM PMID[529473]
NPT197 Protein-Protein Interaction Menin/Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 39810.7 nM PMID[529474]
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 28183.8 nM PMID[529474]
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 10000.0 nM PMID[529475]
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 31622.8 nM PMID[529476]
NPT2 Others Unspecified Potency = 9200.0 nM PMID[529476]
NPT2 Others Unspecified Potency = 141.3 nM PMID[529474]
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Potency n.a. 41.5 nM PMID[529476]
NPT7 Individual Protein Thioredoxin reductase 1, cytoplasmic Rattus norvegicus Potency n.a. 56234.1 nM PMID[529476]
NPT2 Others Unspecified Potency n.a. 2511.9 nM PMID[529476]
NPT67 Individual Protein Cholinesterase Equus caballus Inhibition = 6.79 % PMID[529478]
NPT1419 Organism Tribolium castaneum Tribolium castaneum EC50 = 75.71 ppm PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais EC50 = 129.72 ppm PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum FDI = 89.56 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum FDI = 68.62 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum FDI = 57.45 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum FDI = 30.12 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum FDI = 13.21 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum FDI = 4.31 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais FDI = 82.43 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais FDI = 60.24 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais FDI = 47.32 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais FDI = 26.12 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais FDI = 10.21 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais FDI = 3.53 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum mortality = 14.0 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum mortality = 6.0 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum mortality = 2.0 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum mortality = 0.0 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais mortality = 10.0 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais mortality = 4.0 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais mortality = 0.0 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum ECI = 7.81 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum ECI = 10.03 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum ECI = 13.72 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum ECI = 15.12 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum ECI = 19.41 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum ECI = 20.25 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais ECI = 4.21 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais ECI = 6.81 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais ECI = 8.37 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais ECI = 10.34 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais ECI = 10.67 % PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais ECI = 10.98 % PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 15.72 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 31.56 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 61.88 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 101.27 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 124.71 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 137.89 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 18.31 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 45.13 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 59.65 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 92.84 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 112.77 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 120.9 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 1.23 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 3.17 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 8.49 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 15.31 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 24.21 ug/mg/day PMID[529479]
NPT1419 Organism Tribolium castaneum Tribolium castaneum Activity = 27.92 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 0.77 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 3.07 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 4.99 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 9.6 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 12.03 ug/mg/day PMID[529479]
NPT780 Organism Sitophilus zeamais Sitophilus zeamais Activity = 13.27 ug/mg/day PMID[529479]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 IC50 > 20000.0 nM PMID[529482]
NPT20555 ORGANISM SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 IC50 > 19952.62 nM PMID[529482]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

  Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC34770 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9718 High Similarity NPC166712
0.9673 High Similarity NPC160100
0.9673 High Similarity NPC208364
0.9583 High Similarity NPC58209
0.9495 High Similarity NPC173250
0.9452 High Similarity NPC203373
0.9387 High Similarity NPC217176
0.9245 High Similarity NPC140296
0.9241 High Similarity NPC120513
0.9231 High Similarity NPC131885
0.9087 High Similarity NPC168922
0.9005 High Similarity NPC298436
0.8964 High Similarity NPC188400
0.8925 High Similarity NPC205372
0.8844 High Similarity NPC1608
0.8796 High Similarity NPC97746
0.8729 High Similarity NPC101312
0.8638 High Similarity NPC16066
0.8626 High Similarity NPC269367
0.8279 Intermediate Similarity NPC219664
0.8203 Intermediate Similarity NPC203168
0.787 Intermediate Similarity NPC66815
0.7822 Intermediate Similarity NPC208084
0.7796 Intermediate Similarity NPC230683
0.7763 Intermediate Similarity NPC314633
0.7748 Intermediate Similarity NPC146418
0.7645 Intermediate Similarity NPC473188
0.7581 Intermediate Similarity NPC209981
0.7576 Intermediate Similarity NPC179287
0.7571 Intermediate Similarity NPC185197
0.7523 Intermediate Similarity NPC112937
0.7511 Intermediate Similarity NPC187501
0.749 Intermediate Similarity NPC470042
0.7467 Intermediate Similarity NPC46561
0.7403 Intermediate Similarity NPC225279
0.7401 Intermediate Similarity NPC308137
0.7401 Intermediate Similarity NPC310211
0.7386 Intermediate Similarity NPC119134
0.7381 Intermediate Similarity NPC315634
0.7381 Intermediate Similarity NPC100734
0.7381 Intermediate Similarity NPC88923
0.7371 Intermediate Similarity NPC198503
0.7368 Intermediate Similarity NPC39500
0.7359 Intermediate Similarity NPC288987
0.7359 Intermediate Similarity NPC148409
0.7333 Intermediate Similarity NPC249583
0.732 Intermediate Similarity NPC284685
0.7291 Intermediate Similarity NPC89549
0.7273 Intermediate Similarity NPC169402
0.7269 Intermediate Similarity NPC474688
0.7265 Intermediate Similarity NPC144452
0.7261 Intermediate Similarity NPC116238
0.726 Intermediate Similarity NPC79293
0.726 Intermediate Similarity NPC279401
0.7246 Intermediate Similarity NPC200888
0.7243 Intermediate Similarity NPC475844
0.7241 Intermediate Similarity NPC184408
0.7241 Intermediate Similarity NPC247803
0.7222 Intermediate Similarity NPC191489
0.7213 Intermediate Similarity NPC124300
0.72 Intermediate Similarity NPC41216
0.7194 Intermediate Similarity NPC282346
0.719 Intermediate Similarity NPC6786
0.7185 Intermediate Similarity NPC274640
0.7184 Intermediate Similarity NPC291609
0.7179 Intermediate Similarity NPC174760
0.7179 Intermediate Similarity NPC150239
0.7177 Intermediate Similarity NPC134637
0.7171 Intermediate Similarity NPC318068
0.7167 Intermediate Similarity NPC195120
0.7167 Intermediate Similarity NPC87560
0.7166 Intermediate Similarity NPC161801
0.7143 Intermediate Similarity NPC268223
0.7137 Intermediate Similarity NPC45190
0.7137 Intermediate Similarity NPC329631
0.7137 Intermediate Similarity NPC270515
0.7126 Intermediate Similarity NPC310618
0.7115 Intermediate Similarity NPC129897
0.7112 Intermediate Similarity NPC148391
0.7107 Intermediate Similarity NPC39370
0.7107 Intermediate Similarity NPC253675
0.7106 Intermediate Similarity NPC157983
0.7106 Intermediate Similarity NPC118154
0.7105 Intermediate Similarity NPC4687
0.7097 Intermediate Similarity NPC42591
0.7089 Intermediate Similarity NPC94842
0.7082 Intermediate Similarity NPC227824
0.7069 Intermediate Similarity NPC114468
0.7054 Intermediate Similarity NPC476999
0.7051 Intermediate Similarity NPC62069
0.7048 Intermediate Similarity NPC317572
0.7045 Intermediate Similarity NPC45389
0.704 Intermediate Similarity NPC165964
0.7039 Intermediate Similarity NPC2905
0.7033 Intermediate Similarity NPC207620
0.7033 Intermediate Similarity NPC148889
0.7031 Intermediate Similarity NPC474595
0.7026 Intermediate Similarity NPC264176
0.7025 Intermediate Similarity NPC473186
0.7022 Intermediate Similarity NPC280714
0.7021 Intermediate Similarity NPC134702
0.7018 Intermediate Similarity NPC470930
0.7012 Intermediate Similarity NPC67401
0.7007 Intermediate Similarity NPC169716
0.7004 Intermediate Similarity NPC76478
0.7 Intermediate Similarity NPC13249
0.6996 Remote Similarity NPC474594
0.6996 Remote Similarity NPC172222
0.6992 Remote Similarity NPC41501
0.6988 Remote Similarity NPC107123
0.6983 Remote Similarity NPC87413
0.698 Remote Similarity NPC477589
0.698 Remote Similarity NPC477587
0.6971 Remote Similarity NPC476997
0.6967 Remote Similarity NPC90875
0.6966 Remote Similarity NPC118228
0.6966 Remote Similarity NPC146976
0.6964 Remote Similarity NPC49672
0.6962 Remote Similarity NPC469439
0.6958 Remote Similarity NPC470018
0.6955 Remote Similarity NPC314222
0.6955 Remote Similarity NPC196449
0.6951 Remote Similarity NPC230403
0.6949 Remote Similarity NPC182853
0.6948 Remote Similarity NPC124313
0.6942 Remote Similarity NPC476996
0.6942 Remote Similarity NPC476998
0.6936 Remote Similarity NPC3207
0.6935 Remote Similarity NPC207283
0.6935 Remote Similarity NPC84164
0.6933 Remote Similarity NPC118189
0.6923 Remote Similarity NPC236668
0.6923 Remote Similarity NPC477586
0.6923 Remote Similarity NPC477585
0.6923 Remote Similarity NPC477588
0.6923 Remote Similarity NPC477590
0.6914 Remote Similarity NPC474701
0.6913 Remote Similarity NPC304183
0.6913 Remote Similarity NPC300156
0.6911 Remote Similarity NPC184680
0.691 Remote Similarity NPC294375
0.6909 Remote Similarity NPC204385
0.6901 Remote Similarity NPC476994
0.6891 Remote Similarity NPC54066
0.6885 Remote Similarity NPC233334
0.6884 Remote Similarity NPC312872
0.6883 Remote Similarity NPC470785
0.6883 Remote Similarity NPC321428
0.6883 Remote Similarity NPC283117
0.6883 Remote Similarity NPC166722
0.688 Remote Similarity NPC38237
0.6878 Remote Similarity NPC174576
0.6875 Remote Similarity NPC51388
0.6875 Remote Similarity NPC475190
0.6873 Remote Similarity NPC132385
0.6872 Remote Similarity NPC118511
0.6872 Remote Similarity NPC24019
0.687 Remote Similarity NPC473187
0.6863 Remote Similarity NPC303374
0.6862 Remote Similarity NPC7560
0.6853 Remote Similarity NPC72715
0.6853 Remote Similarity NPC86834
0.6853 Remote Similarity NPC210828
0.6851 Remote Similarity NPC30749
0.6851 Remote Similarity NPC232225
0.6846 Remote Similarity NPC473449
0.6842 Remote Similarity NPC476995
0.6842 Remote Similarity NPC189903
0.6842 Remote Similarity NPC182907
0.684 Remote Similarity NPC472286
0.684 Remote Similarity NPC472287
0.6838 Remote Similarity NPC23294
0.6835 Remote Similarity NPC293151
0.6834 Remote Similarity NPC471978
0.6833 Remote Similarity NPC194040
0.6831 Remote Similarity NPC194740
0.6824 Remote Similarity NPC185782
0.682 Remote Similarity NPC471979
0.6816 Remote Similarity NPC102593
0.6816 Remote Similarity NPC144381
0.6816 Remote Similarity NPC196718
0.6813 Remote Similarity NPC78609
0.6812 Remote Similarity NPC470586
0.6811 Remote Similarity NPC133609
0.6811 Remote Similarity NPC302807
0.6811 Remote Similarity NPC183537
0.6809 Remote Similarity NPC258048
0.6809 Remote Similarity NPC26679
0.6804 Remote Similarity NPC206201
0.6804 Remote Similarity NPC474798
0.6802 Remote Similarity NPC108342
0.6802 Remote Similarity NPC470017
0.6802 Remote Similarity NPC66083
0.6797 Remote Similarity NPC472435
0.6795 Remote Similarity NPC470020
0.6795 Remote Similarity NPC303951
0.6795 Remote Similarity NPC215837
0.679 Remote Similarity NPC74575
0.6789 Remote Similarity NPC287152
0.6783 Remote Similarity NPC199277

  Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC34770 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7639 Intermediate Similarity NPD1505 Phase 2
0.7611 Intermediate Similarity NPD2433 Clinical (unspecified phase)
0.7531 Intermediate Similarity NPD6525 Clinical (unspecified phase)
0.7511 Intermediate Similarity NPD6974 Phase 3
0.7409 Intermediate Similarity NPD2778 Approved
0.7381 Intermediate Similarity NPD7803 Approved
0.732 Intermediate Similarity NPD7955 Approved
0.732 Intermediate Similarity NPD7956 Approved
0.7309 Intermediate Similarity NPD2779 Approved
0.73 Intermediate Similarity NPD4898 Clinical (unspecified phase)
0.7284 Intermediate Similarity NPD6716 Phase 1
0.7237 Intermediate Similarity NPD1166 Clinical (unspecified phase)
0.7222 Intermediate Similarity NPD7708 Approved
0.7197 Intermediate Similarity NPD1867 Approved
0.7179 Intermediate Similarity NPD7180 Phase 3
0.7155 Intermediate Similarity NPD5924 Discontinued
0.7137 Intermediate Similarity NPD6741 Clinical (unspecified phase)
0.7119 Intermediate Similarity NPD6160 Clinical (unspecified phase)
0.7112 Intermediate Similarity NPD4667 Clinical (unspecified phase)
0.7108 Intermediate Similarity NPD5482 Discontinued
0.7096 Intermediate Similarity NPD7690 Clinical (unspecified phase)
0.7094 Intermediate Similarity NPD5632 Approved
0.7083 Intermediate Similarity NPD4952 Phase 3
0.7083 Intermediate Similarity NPD5022 Discontinued
0.7069 Intermediate Similarity NPD3945 Discontinued
0.7064 Intermediate Similarity NPD2899 Discontinued
0.7059 Intermediate Similarity NPD3925 Approved
0.7054 Intermediate Similarity NPD1467 Approved
0.7054 Intermediate Similarity NPD1466 Phase 3
0.7039 Intermediate Similarity NPD3257 Approved
0.7039 Intermediate Similarity NPD5417 Clinical (unspecified phase)
0.7033 Intermediate Similarity NPD7417 Discontinued
0.7029 Intermediate Similarity NPD3263 Phase 3
0.7024 Intermediate Similarity NPD4926 Clinical (unspecified phase)
0.7017 Intermediate Similarity NPD7547 Clinical (unspecified phase)
0.7008 Intermediate Similarity NPD7853 Phase 2
0.7008 Intermediate Similarity NPD3006 Discontinued
0.7 Intermediate Similarity NPD4328 Approved
0.6996 Remote Similarity NPD4373 Phase 2
0.6992 Remote Similarity NPD7885 Phase 2
0.6992 Remote Similarity NPD7886 Phase 2
0.6992 Remote Similarity NPD7025 Clinical (unspecified phase)
0.6987 Remote Similarity NPD3507 Phase 2
0.6984 Remote Similarity NPD7859 Phase 2
0.6983 Remote Similarity NPD6567 Clinical (unspecified phase)
0.6975 Remote Similarity NPD2285 Clinical (unspecified phase)
0.6967 Remote Similarity NPD6964 Approved
0.6967 Remote Similarity NPD6963 Approved
0.6967 Remote Similarity NPD2951 Discontinued
0.6964 Remote Similarity NPD6790 Phase 1
0.6964 Remote Similarity NPD5512 Phase 3
0.6949 Remote Similarity NPD4429 Discontinued
0.6948 Remote Similarity NPD5483 Clinical (unspecified phase)
0.6923 Remote Similarity NPD2921 Clinical (unspecified phase)
0.692 Remote Similarity NPD3258 Approved
0.6917 Remote Similarity NPD6247 Clinical (unspecified phase)
0.6914 Remote Similarity NPD6962 Phase 2
0.6908 Remote Similarity NPD5922 Phase 3
0.6889 Remote Similarity NPD6550 Discontinued
0.6888 Remote Similarity NPD5640 Discontinued
0.6887 Remote Similarity NPD6228 Discontinued
0.6878 Remote Similarity NPD7395 Discontinued
0.6872 Remote Similarity NPD5479 Discontinued
0.6867 Remote Similarity NPD1483 Discontinued
0.6842 Remote Similarity NPD5805 Approved
0.6842 Remote Similarity NPD4846 Phase 2
0.6833 Remote Similarity NPD6824 Clinical (unspecified phase)
0.6825 Remote Similarity NPD3328 Phase 2
0.6824 Remote Similarity NPD5532 Phase 2
0.6822 Remote Similarity NPD5293 Phase 2
0.6816 Remote Similarity NPD7031 Phase 1
0.6816 Remote Similarity NPD4885 Approved
0.681 Remote Similarity NPD5429 Discontinued
0.6809 Remote Similarity NPD5866 Approved
0.6789 Remote Similarity NPD6494 Phase 2
0.6789 Remote Similarity NPD3920 Phase 2
0.6782 Remote Similarity NPD5450 Discontinued
0.6781 Remote Similarity NPD5658 Approved
0.678 Remote Similarity NPD7571 Clinical (unspecified phase)
0.6774 Remote Similarity NPD4368 Phase 2
0.6773 Remote Similarity NPD6495 Clinical (unspecified phase)
0.6766 Remote Similarity NPD5416 Discontinued
0.6766 Remote Similarity NPD7703 Clinical (unspecified phase)
0.6757 Remote Similarity NPD5256 Discontinued
0.6751 Remote Similarity NPD1638 Discovery
0.6744 Remote Similarity NPD8091 Phase 3
0.6742 Remote Similarity NPD5083 Clinical (unspecified phase)
0.6732 Remote Similarity NPD8102 Discontinued
0.6724 Remote Similarity NPD3946 Clinical (unspecified phase)
0.6721 Remote Similarity NPD3259 Approved
0.6719 Remote Similarity NPD5857 Phase 3
0.6719 Remote Similarity NPD5488 Discontinued
0.6707 Remote Similarity NPD4958 Clinical (unspecified phase)
0.6696 Remote Similarity NPD6861 Clinical (unspecified phase)
0.6695 Remote Similarity NPD5443 Clinical (unspecified phase)
0.6693 Remote Similarity NPD8463 Approved
0.6681 Remote Similarity NPD5903 Approved
0.6681 Remote Similarity NPD5902 Approved
0.6667 Remote Similarity NPD7022 Phase 2
0.6654 Remote Similarity NPD8359 Phase 2
0.6654 Remote Similarity NPD5817 Discontinued
0.6653 Remote Similarity NPD648 Clinical (unspecified phase)
0.6653 Remote Similarity NPD3392 Approved
0.6653 Remote Similarity NPD6625 Approved
0.6631 Remote Similarity NPD6745 Discontinued
0.6628 Remote Similarity NPD6252 Clinical (unspecified phase)
0.6623 Remote Similarity NPD4418 Discontinued
0.6616 Remote Similarity NPD6456 Discontinued
0.6614 Remote Similarity NPD4394 Clinical (unspecified phase)
0.6612 Remote Similarity NPD5930 Phase 3
0.6612 Remote Similarity NPD7426 Phase 1
0.6611 Remote Similarity NPD7538 Clinical (unspecified phase)
0.66 Remote Similarity NPD3250 Phase 1
0.6599 Remote Similarity NPD1659 Phase 1
0.6596 Remote Similarity NPD7222 Phase 2
0.6585 Remote Similarity NPD7268 Clinical (unspecified phase)
0.6585 Remote Similarity NPD6553 Clinical (unspecified phase)
0.6582 Remote Similarity NPD2081 Clinical (unspecified phase)
0.6582 Remote Similarity NPD5914 Approved
0.6573 Remote Similarity NPD3442 Approved
0.6573 Remote Similarity NPD3441 Approved
0.6573 Remote Similarity NPD7284 Clinical (unspecified phase)
0.657 Remote Similarity NPD3875 Discontinued
0.6568 Remote Similarity NPD7467 Discontinued
0.6556 Remote Similarity NPD3217 Phase 2
0.6554 Remote Similarity NPD5459 Phase 2
0.6553 Remote Similarity NPD3842 Clinical (unspecified phase)
0.6545 Remote Similarity NPD1955 Discontinued
0.654 Remote Similarity NPD7862 Clinical (unspecified phase)
0.6537 Remote Similarity NPD4369 Phase 2
0.6535 Remote Similarity NPD3921 Approved
0.6535 Remote Similarity NPD3924 Approved
0.6535 Remote Similarity NPD3922 Approved
0.6535 Remote Similarity NPD6517 Phase 3
0.6535 Remote Similarity NPD3923 Approved
0.6532 Remote Similarity NPD7589 Clinical (unspecified phase)
0.6524 Remote Similarity NPD6321 Discontinued
0.652 Remote Similarity NPD8460 Approved
0.652 Remote Similarity NPD2565 Phase 2
0.652 Remote Similarity NPD8459 Approved
0.652 Remote Similarity NPD2564 Approved
0.6514 Remote Similarity NPD4724 Clinical (unspecified phase)
0.6512 Remote Similarity NPD3986 Discontinued
0.6502 Remote Similarity NPD2884 Phase 1
0.6496 Remote Similarity NPD5006 Approved
0.6496 Remote Similarity NPD5005 Approved
0.6492 Remote Similarity NPD7710 Clinical (unspecified phase)
0.6485 Remote Similarity NPD4502 Phase 2
0.6485 Remote Similarity NPD683 Approved
0.6483 Remote Similarity NPD3003 Approved
0.6478 Remote Similarity NPD6590 Discontinued
0.6473 Remote Similarity NPD7012 Phase 3
0.6473 Remote Similarity NPD8350 Clinical (unspecified phase)
0.6473 Remote Similarity NPD7013 Phase 3
0.6466 Remote Similarity NPD4420 Approved
0.6458 Remote Similarity NPD3815 Phase 1
0.6458 Remote Similarity NPD7069 Discontinued
0.6458 Remote Similarity NPD3816 Phase 1
0.6456 Remote Similarity NPD7452 Approved
0.6456 Remote Similarity NPD7453 Approved
0.6454 Remote Similarity NPD7558 Phase 2
0.6452 Remote Similarity NPD3899 Clinical (unspecified phase)
0.645 Remote Similarity NPD8255 Phase 2
0.645 Remote Similarity NPD6961 Discontinued
0.6448 Remote Similarity NPD6243 Phase 3
0.6448 Remote Similarity NPD6244 Phase 3
0.6443 Remote Similarity NPD946 Discontinued
0.6438 Remote Similarity NPD1768 Approved
0.6437 Remote Similarity NPD2311 Clinical (unspecified phase)
0.6434 Remote Similarity NPD8466 Approved
0.6434 Remote Similarity NPD8465 Approved
0.6434 Remote Similarity NPD3763 Approved
0.6434 Remote Similarity NPD8467 Approved
0.6429 Remote Similarity NPD6104 Discontinued
0.6429 Remote Similarity NPD5863 Clinical (unspecified phase)
0.6423 Remote Similarity NPD6503 Clinical (unspecified phase)
0.6422 Remote Similarity NPD6988 Phase 1
0.6422 Remote Similarity NPD5003 Discontinued
0.642 Remote Similarity NPD5164 Discontinued
0.642 Remote Similarity NPD3949 Clinical (unspecified phase)
0.6417 Remote Similarity NPD7729 Clinical (unspecified phase)
0.6414 Remote Similarity NPD4305 Clinical (unspecified phase)
0.6414 Remote Similarity NPD3746 Discontinued
0.6408 Remote Similarity NPD6242 Discontinued
0.6408 Remote Similarity NPD5850 Phase 3
0.6406 Remote Similarity NPD4875 Phase 3
0.6406 Remote Similarity NPD4876 Phase 3
0.6395 Remote Similarity NPD8100 Phase 3
0.6393 Remote Similarity NPD1926 Approved
0.639 Remote Similarity NPD4927 Discontinued
0.6386 Remote Similarity NPD7994 Phase 2
0.6385 Remote Similarity NPD7588 Discontinued
0.6382 Remote Similarity NPD4923 Phase 1
0.6375 Remote Similarity NPD4900 Clinical (unspecified phase)
0.6356 Remote Similarity NPD4204 Approved
0.6356 Remote Similarity NPD4203 Approved
0.6356 Remote Similarity NPD956 Clinical (unspecified phase)
0.6349 Remote Similarity NPD7796 Approved
0.6349 Remote Similarity NPD7797 Approved
0.6342 Remote Similarity NPD4322 Discontinued

  Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity
B: biological targets similarity
C: networks similarity
D: cell-based bioactivity similarity
E: similarity based on clinical data