NPASS Compound

Structure

NPC331613 OpenBabel06302215212D 28 31 0 0 1 0 0 0 0 0999 V2000 1.6561 -0.0163 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.8125 0.4701 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 0.8122 1.4091 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8142 1.4087 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -1.6281 1.8782 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -1.6284 2.8179 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.4423 3.2875 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.2559 2.8174 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.0693 3.2870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.8824 2.8169 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.7259 3.3033 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.8821 1.8773 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.0687 1.4077 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.2557 1.8778 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -3.2554 0.9040 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.4418 1.4082 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -2.4415 0.4691 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -1.6276 -0.0005 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8139 0.4696 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -0.8136 -0.5042 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.0000 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 0.0003 -0.9387 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.6971 -1.5670 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8931 -1.2285 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0885 -2.1466 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.8391 -0.4841 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -3.2803 -0.0155 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.1194 0.4390 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 2 1 1 1 0 0 0 2 3 1 0 0 0 0 2 21 1 0 0 0 0 4 3 1 6 0 0 0 4 5 1 0 0 0 0 4 19 1 0 0 0 0 5 6 1 1 0 0 0 5 16 1 0 0 0 0 6 7 1 0 0 0 0 7 8 1 0 0 0 0 8 14 1 0 0 0 0 8 9 2 0 0 0 0 9 10 1 0 0 0 0 10 11 2 0 0 0 0 10 12 1 0 0 0 0 12 13 2 0 0 0 0 13 14 1 0 0 0 0 14 15 1 6 0 0 0 14 16 1 0 0 0 0 16 17 1 0 0 0 0 16 28 1 1 0 0 0 17 18 1 0 0 0 0 17 27 1 6 0 0 0 18 19 1 0 0 0 0 19 20 1 6 0 0 0 19 21 1 0 0 0 0 21 22 1 0 0 0 0 21 26 1 1 0 0 0 22 23 2 0 0 0 0 22 24 1 0 0 0 0 24 25 1 0 0 0 0 M END $$$$

Physi-Chem Properties

Molecular Weight:	392.2
Volume:	394.315
LogP:	2.495
LogD:	2.189
LogS:	-4.056
# Rotatable Bonds:	2
TPSA:	94.83
# H-Bond Aceptor:	5
# H-Bond Donor:	3
# Rings:	4
# Heavy Atoms:	6

MedChem Properties

QED Drug-Likeness Score:	0.624
Synthetic Accessibility Score:	4.877
Fsp3:	0.727
Lipinski Rule-of-5:	Accepted
Pfizer Rule:	Accepted
GSK Rule:	Accepted
BMS Rule:	0
Golden Triangle Rule:	Accepted
Chelating Alert:	0
PAINS Alert:	0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:	-4.888
MDCK Permeability:	1.7049189409590326e-05
Pgp-inhibitor:	0.004
Pgp-substrate:	0.402
Human Intestinal Absorption (HIA):	0.005
20% Bioavailability (F20%):	0.109
30% Bioavailability (F30%):	0.048

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.88
Plasma Protein Binding (PPB):	56.017826080322266%
Volume Distribution (VD):	1.102
Pgp-substrate:	38.66096496582031%

ADMET: Metabolism

CYP1A2-inhibitor:	0.008
CYP1A2-substrate:	0.44
CYP2C19-inhibitor:	0.015
CYP2C19-substrate:	0.671
CYP2C9-inhibitor:	0.015
CYP2C9-substrate:	0.047
CYP2D6-inhibitor:	0.001
CYP2D6-substrate:	0.019
CYP3A4-inhibitor:	0.788
CYP3A4-substrate:	0.777

ADMET: Excretion

Clearance (CL):	3.341
Half-life (T1/2):	0.916

ADMET: Toxicity

hERG Blockers:	0.053
Human Hepatotoxicity (H-HT):	0.27
Drug-inuced Liver Injury (DILI):	0.205
AMES Toxicity:	0.15
Rat Oral Acute Toxicity:	0.986
Maximum Recommended Daily Dose:	0.991
Skin Sensitization:	0.935
Carcinogencity:	0.878
Eye Corrosion:	0.298
Eye Irritation:	0.496
Respiratory Toxicity:	0.992

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs

Natural Product: NPC331613

Natural Product ID:	NPC331613
*Common Name:**	UREBDLICKHMUKA-CXSFZGCWSA-N
IUPAC Name:	n.a.
Synonyms:
Standard InCHIKey:	UREBDLICKHMUKA-CXSFZGCWSA-N
Standard InCHI:	InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
SMILES:	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3([C@H](C[C@]2(C)[C@]1(C(=O)CO)O)O)F
Synthetic Gene Cluster:	n.a.
ChEMBL Identifier:	n.a.
PubChem CID:	5743
Chemical Classification:**	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000012] Lipids and lipid-like molecules [CHEMONTID:0000258] Steroids and steroid derivatives [CHEMONTID:0001295] Hydroxysteroids [CHEMONTID:0003095] 21-hydroxysteroids

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	seed	n.a.	DOI[10.1016/0031-9422(96)00258-0]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Anhui province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Gansu province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Henan province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Shandong province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Shanxi province, China		DOI[10.1016/j.foodres.2020.109416]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	fruit	n.a.	DOI[10.1016/S1383-5769(99)00023-9]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	DOI[10.2174/092986712800229032]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[10086989]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	seeds	n.a.	n.a.	PMID[11087592]
NPO29042	Vincetoxicum atratum	Species	Apocynaceae	Eukaryota	Roots	n.a.	n.a.	PMID[11374953]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12542364]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	stem bark	Indonesia	1999-SEP	PMID[14510596]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	n.a.	stem	n.a.	PMID[14510596]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[1512598]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	Seeds	n.a.	n.a.	PMID[15165151]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	seeds	n.a.	n.a.	PMID[15730242]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	bark	n.a.	PMID[1593281]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	flowers	n.a.	n.a.	PMID[15974620]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	fruit	n.a.	PMID[16268506]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16309313]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	root	n.a.	PMID[16564530]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17580910]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	fruit	Indonesia	n.a.	PMID[17896817]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18321057]
NPO3821	Sinularia flexibilis	Species	Alcyoniidae	Eukaryota	n.a.	chinese soft coral	n.a.	PMID[18553926]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	Vietnam	n.a.	PMID[19026551]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	whole plant	n.a.	PMID[19099222]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19402674]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[19721258]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[19772486]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	seeds	n.a.	n.a.	PMID[20050684]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Roots	n.a.	n.a.	PMID[20806783]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[21782011]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21893415]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21954931]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[22190295]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	Seeds	n.a.	n.a.	PMID[22506620]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[22703163]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23270478]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	seed	n.a.	PMID[23497864]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[24328283]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	aerial part	n.a.	PMID[24704554]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25396337]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	dry stem	n.a.	n.a.	PMID[25466192]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	Roots	n.a.	n.a.	PMID[26599832]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[26838074]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27295506]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[27313650]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[27429639]
NPO4734	Syzygium nervosum	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27797185]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28448136]
NPO40871	Laserpitium zernyi	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[28489375]
NPO27950	Aspergillus ochraceopetaliformis	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28598633]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28617598]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	Leaves	n.a.	n.a.	PMID[29272126]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	Roots	n.a.	n.a.	PMID[29359942]
NPO40105	Dietes bicolor	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29381070]
NPO40980	Penicillium chrysogenum J08NF-4	Strain	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29389121]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	Roots	n.a.	n.a.	PMID[29482940]
NPO40028	Artemisia freyniana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29518326]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Roots	n.a.	n.a.	PMID[29741372]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30028612]
NPO40356	Spondias pinnata	Species	Anacardiaceae	Eukaryota	Bark	n.a.	n.a.	PMID[30215255]
NPO3821	Sinularia flexibilis	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	PMID[30528697]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30649869]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30724086]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30817151]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30931559]
NPO40479	Colletotrichum sp. S8.	Strain	Glomerellaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31181925]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[31301930]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31550154]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31577434]
NPO14563	Kalimeris shimadae	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31804830]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	Rhizomes	n.a.	n.a.	PMID[31873014]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	Roots	n.a.	n.a.	PMID[31944695]
NPO40401	Xylaria longipes	Species	Xylariaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31961677]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	Whole Fruits	n.a.	n.a.	PMID[32159343]
NPO40847	Evolvulus linarioides	Species	n.a.	n.a.	Aerial Parts	n.a.	n.a.	PMID[32364737]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	HeZe, ShanDong, China	early autumn (from August to the beginning of September	PMID[32545196]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32935986]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Roots	n.a.	n.a.	PMID[32951423]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Xinjiang,China		PMID[33063333]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[33264011]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[6481366]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7561896]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	Roots; Tubers	n.a.	n.a.	PMID[7714535]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	seeds	n.a.	n.a.	PMID[8676130]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[8946743]
NPO3821	Sinularia flexibilis	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	PMID[9644083]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[Article]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[Article]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29042	Vincetoxicum atratum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO29042	Vincetoxicum atratum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14563	Kalimeris shimadae	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29042	Vincetoxicum atratum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4734	Syzygium nervosum	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27950	Aspergillus ochraceopetaliformis	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	NP ID	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
EC50	71
ED50	7
IC50	208
Kd	4
Ki	21
LD50	1
Others	394
Potency	2

Activity Type	# Activity
Cell Line	237
CELL-LINE	4
Individual Protein	211
NON-MOLECULAR	14
Organism	193
Others	36
Protein Family	1
SINGLE PROTEIN	9
Subcellular	1
Tissue	2

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	420.0	nM	PMID[12361395]
NPT848	Cell Line	N9	Homo sapiens	IC50	=	74.0	nM	PMID[12361395]
NPT4316	Individual Protein	Phospholipase A2 group 1B	Rattus norvegicus	IC50	>	750000.0	nM	DOI[10.1016/S0960-894X(01)81260-9]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	>	25000.0	nM	DOI[10.1016/S0960-894X(01)81260-9]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	5.5	nM	PMID[8627601]
NPT1886	Cell Line	J774	Mus musculus	IC50	=	169500.0	nM	PMID[12467611]
NPT2945	Individual Protein	Phospholipase A2 group 1B	Sus scrofa	IC50	>	750000.0	nM	DOI[10.1016/S0960-894X(01)81022-2]
NPT183	Individual Protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	120000.0	nM	DOI[10.1016/S0960-894X(01)81022-2]
NPT2246	Cell Line	T-cells		IC50	=	5.0	nM	PMID[11229767]
NPT109	Individual Protein	Cytochrome P450 3A4	Homo sapiens	IC50	>	50000.0	nM	PMID[12699389]
NPT1455	Individual Protein	P-glycoprotein 3	Mus musculus	IC50	>	50000.0	nM	PMID[12699389]
NPT1456	Individual Protein	P-glycoprotein 1	Mus musculus	IC50	>	50000.0	nM	PMID[12699389]
NPT1455	Individual Protein	P-glycoprotein 3	Mus musculus	Ratio	=	0.8	n.a.	PMID[12699389]
NPT1455	Individual Protein	P-glycoprotein 3	Mus musculus	Ratio	=	2.3	n.a.	PMID[12699389]
NPT1455	Individual Protein	P-glycoprotein 3	Mus musculus	Ratio	=	5.2	n.a.	PMID[12699389]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	<	10000.0	nM	PMID[15999989]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.0	nM	PMID[16112571]
NPT299	Individual Protein	Androgen Receptor	Rattus norvegicus	IC50	=	81283.05	nM	PMID[16134935]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	5.012	nM	PMID[16821781]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	>	10000.0	nM	PMID[16821781]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.175	nM	PMID[16821781]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	7.943	nM	PMID[16821781]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[17181172]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[17181172]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[17181172]
NPT859	Cell Line	HFF	Homo sapiens	IC50	=	0.51	nM	PMID[17181172]
NPT859	Cell Line	HFF	Homo sapiens	EC50	=	1.9	nM	PMID[17181172]
NPT165	Cell Line	HeLa	Homo sapiens	EC50	=	17.0	nM	PMID[17181172]
NPT2735	Cell Line	RAW	Mus musculus	IC50	=	20.0	nM	PMID[17367124]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	3.4	ng/ml	PMID[17407277]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	0.21	ng/ml	PMID[17407277]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	0.2	nM	PMID[17705362]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.4	nM	PMID[17705362]
NPT389	Cell Line	RPMI-8226	Homo sapiens	IC50	=	6.5	nM	PMID[17705362]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	2.1	nM	PMID[17705362]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	Ki	=	7.2	nM	PMID[17705362]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.4	nM	PMID[17118655]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[17118655]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[17118655]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	7.586	nM	PMID[17616395]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.0	nM	PMID[17616395]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	102.0	%	PMID[17616395]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	5.37	nM	PMID[17616395]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	<	1000.0	nM	PMID[17616395]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Inhibition	=	7.0	%	PMID[17616395]
NPT859	Cell Line	HFF	Homo sapiens	EC50	=	2.0	nM	PMID[17692519]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[17692519]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[17692519]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[17692519]
NPT859	Cell Line	HFF	Homo sapiens	EC50	=	0.5	nM	PMID[17692519]
NPT1182	Cell Line	J774.A1	Mus musculus	IC50	=	48.0	nM	PMID[17892941]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	7.943	nM	PMID[18038970]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	5.012	nM	PMID[18038970]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.175	nM	PMID[18038970]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	110.0	%	PMID[18038970]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	102.0	%	PMID[18038970]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	>	10000.0	nM	PMID[18038970]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	ED50	=	0.1	nM	PMID[18032610]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ratio	=	2.56	n.a.	PMID[18177009]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	49.9	%	PMID[11374953]
NPT848	Cell Line	N9	Homo sapiens	Inhibition	=	82.0	%	PMID[11374953]
NPT1135	Cell Line	Hepatocyte	Rattus norvegicus	Activity	=	96.0	IU/L	PMID[6677713]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	36.0	ug.mL-1	PMID[15165136]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	>	25.0	ug.mL-1	PMID[15165136]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	5.0	nM	PMID[18490170]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	5.0	nM	PMID[18412397]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	3.0	nM	PMID[18983139]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	6.0	nM	PMID[18983139]
NPT3031	Individual Protein	Estrogen receptor alpha	Rattus norvegicus	Activity	=	0.0	%	PMID[18472187]
NPT299	Individual Protein	Androgen Receptor	Rattus norvegicus	Activity	=	0.0	%	PMID[18472187]
NPT3036	Individual Protein	Progesterone receptor	Rattus norvegicus	Activity	=	0.0	%	PMID[18472187]
NPT1454	Individual Protein	Glucocorticoid receptor	Rattus norvegicus	Activity	=	66.0	%	PMID[18472187]
NPT5538	Individual Protein	Fatty acid-binding protein, liver	Rattus norvegicus	Ki	=	22100.0	nM	PMID[18533710]
NPT5538	Individual Protein	Fatty acid-binding protein, liver	Rattus norvegicus	Ki	=	41300.0	nM	PMID[18533710]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.1	nM	PMID[19321341]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[19321341]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[19321341]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.2	nM	PMID[19321341]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	700.0	nM	PMID[11908984]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ratio	=	1.99	n.a.	PMID[17067160]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.0	nM	PMID[16643060]
NPT1970	Cell Line	THP-1	Homo sapiens	IC50	=	50.0	nM	PMID[18625560]
NPT1970	Cell Line	THP-1	Homo sapiens	IC50	=	7.0	nM	PMID[18625560]
NPT1970	Cell Line	THP-1	Homo sapiens	IC50	>	100000.0	nM	PMID[18625560]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	72.0	%	PMID[18625560]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	94.0	%	PMID[18625560]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	0.0	%	PMID[18625560]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	5.0	nM	PMID[19610652]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.0	nM	PMID[19592247]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.2	nM	PMID[20047280]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[20047280]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[20047280]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.5	nM	PMID[20047280]
NPT153	Individual Protein	Androgen Receptor	Homo sapiens	IC50	>	4000.0	nM	PMID[20047280]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	Inhibition	=	30.0	%	PMID[20047280]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	0.0	%	PMID[19896853]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	90.0	%	PMID[19896853]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	69.0	%	PMID[19896853]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	84.0	%	PMID[20064725]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	73.0	%	PMID[20064725]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	89.0	%	PMID[20056549]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	73.0	%	PMID[20138527]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	84.0	%	PMID[20138527]
NPT1970	Cell Line	THP-1	Homo sapiens	Activity	=	0.0	%	PMID[20138527]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	7.2	nM	PMID[19863083]
NPT927	Cell Line	PBMC	Homo sapiens	Inhibition	=	32.0	%	PMID[19835377]
NPT927	Cell Line	PBMC	Homo sapiens	Inhibition	=	25.0	%	PMID[19835377]
NPT1970	Cell Line	THP-1	Homo sapiens	Activity	=	73.0	%	PMID[20207143]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.1	nM	PMID[20334371]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	87.0	%	PMID[20334371]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	11.4	nM	PMID[20334371]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Kd	=	19.0	nM	PMID[20355713]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	100.0	%	PMID[20427184]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	50.0	%	PMID[20427184]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	69.0	%	PMID[20171758]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	90.0	%	PMID[20171758]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	69.0	%	PMID[20430485]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	90.0	%	PMID[20430485]
NPT1970	Cell Line	THP-1	Homo sapiens	Activity	=	71.0	%	PMID[20638287]
NPT1970	Cell Line	THP-1	Homo sapiens	Activity	=	85.0	%	PMID[20638287]
NPT306	Cell Line	PC-3	Homo sapiens	FC	=	1.127	n.a.	PMID[16680159]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	0.51	nM	PMID[20735001]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.4	nM	PMID[20735001]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[20735001]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[20735001]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	<	15848.93	nM	PMID[20812681]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	0.5082	nM	PMID[20812681]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	7.943	nM	PMID[20727743]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	12.59	nM	PMID[20727743]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[20727743]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[20727743]
NPT153	Individual Protein	Androgen Receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[20727743]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	2.512	nM	PMID[20727743]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.585	nM	PMID[20727743]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	5.0	nM	PMID[20875743]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	860.0	nM	PMID[21288727]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	12.59	nM	PMID[21257309]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.0	nM	PMID[21257309]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	102.0	%	PMID[21257309]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.981	nM	PMID[21257309]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	99.0	%	PMID[21257309]
NPT1454	Individual Protein	Glucocorticoid receptor	Rattus norvegicus	IC50	=	22.0	nM	PMID[21349712]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	800.0	nM	PMID[21353543]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	10.0	nM	PMID[21353543]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	1.54	uM	PMID[21353543]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	27.01	ng/ml	PMID[21353543]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	20.0	nM	PMID[21361338]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.1	nM	PMID[21073190]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[21073190]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[21073190]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.2	nM	PMID[21073190]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	5.0	nM	PMID[21073190]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	71.0	%	PMID[21737269]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	84.0	%	PMID[21737269]
NPT113	Cell Line	RAW264.7	Mus musculus	FC	=	0.16	n.a.	PMID[21598928]
NPT1454	Individual Protein	Glucocorticoid receptor	Rattus norvegicus	IC50	=	22.0	nM	PMID[21944856]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[21963986]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[21963986]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[21963986]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	0.51	nM	PMID[21963986]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.8	nM	PMID[21963986]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	17.0	nM	PMID[21963986]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	72.0	%	PMID[22520258]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	86.0	%	PMID[22520258]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	470.0	nM	PMID[22372956]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	980.0	nM	PMID[22537362]
NPT1733	Individual Protein	Solute carrier organic anion transporter family member 1A2	Homo sapiens	Inhibition	=	97.3	%	PMID[9539145]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	FC	=	10.0	n.a.	PMID[21800856]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	71.0	%	PMID[22981334]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	84.0	%	PMID[22981334]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	84.0	%	PMID[23026000]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	76.0	%	PMID[23026000]
NPT622	Individual Protein	Solute carrier organic anion transporter family member 2B1	Homo sapiens	Inhibition	=	-12.5	%	PMID[22541068]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	94.0	%	DOI[10.1007/s00044-011-9856-1]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	72.0	%	DOI[10.1007/s00044-011-9856-1]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	94.0	%	DOI[10.1007/s00044-011-9834-7]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	72.0	%	DOI[10.1007/s00044-011-9834-7]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	84.0	%	DOI[10.1007/s00044-011-9943-3]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	71.0	%	DOI[10.1007/s00044-011-9943-3]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	86.0	%	DOI[10.1007/s00044-012-0144-5]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	72.0	%	DOI[10.1007/s00044-012-0144-5]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	80.0	%	DOI[10.1007/s00044-012-0109-8]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	71.0	%	DOI[10.1007/s00044-012-0109-8]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	355140.0	nM	DOI[10.1007/s00044-013-0504-9]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	5.5	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	1.0	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	3.5	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	3.6	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	>	200.0	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	2.4	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	1.2	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	0.92	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	7.6	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	130.0	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	88.0	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	82.0	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	9.4	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	6.1	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	0.47	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	4.1	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	2.1	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	1.9	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	66.0	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	72.0	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	55.0	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	14.0	nM	PMID[23199485]
NPT927	Cell Line	PBMC	Homo sapiens	EC50	=	10.0	nM	PMID[23199485]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	9.7	nM	PMID[23199485]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	12.5	nM	PMID[23199485]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	3.7	nM	PMID[23199485]
NPT4037	Individual Protein	Multidrug and toxin extrusion protein 1	Homo sapiens	Inhibition	=	30.0	%	PMID[23241029]
NPT4037	Individual Protein	Multidrug and toxin extrusion protein 1	Homo sapiens	IC50	>	500000.0	nM	PMID[23241029]
NPT3087	Individual Protein	Transcription factor p65	Mus musculus	Activity	=	100.0	%	PMID[23219855]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	1430.0	nM	PMID[23373965]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	98.24	%	PMID[23373965]
NPT927	Cell Line	PBMC	Homo sapiens	Inhibition	=	43.0	%	PMID[23411072]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	70.4	%	PMID[23268606]
NPT927	Cell Line	PBMC	Homo sapiens	Inhibition	=	80.0	%	PMID[23411072]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	9.5	nM	PMID[23411072]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	17.0	nM	PMID[23411072]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	2.5	nM	PMID[23582449]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	2.2	nM	PMID[23403082]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	4.1	nM	PMID[23403082]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Inhibition	=	21.0	%	PMID[23403082]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.5	nM	PMID[23466604]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[23466604]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.2	nM	PMID[24011644]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[24011644]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.1	nM	PMID[24011644]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.5	nM	PMID[23916594]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[23916594]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[23916594]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.2	nM	PMID[23916594]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	72.0	%	DOI[10.1007/s00044-013-0825-8]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	85.0	%	DOI[10.1007/s00044-013-0825-8]
NPT1970	Cell Line	THP-1	Homo sapiens	Activity	=	0.0	%	DOI[10.1007/s00044-013-0825-8]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.5	nM	PMID[23953070]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[23953070]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.2	nM	PMID[23953070]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[23953070]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[24215891]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[24215891]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.5	nM	PMID[24215891]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	0.5	nM	PMID[24215891]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	Ki	=	561.0	nM	PMID[24446728]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	Ki	=	0.36	nM	PMID[24446728]
NPT153	Individual Protein	Androgen Receptor	Homo sapiens	Ki	=	1410.0	nM	PMID[24446728]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	0.69	nM	PMID[24446728]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[24656565]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[24656565]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[24656565]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	0.5	nM	PMID[24656565]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	17.0	nM	PMID[24656565]
NPT83	Cell Line	MCF7	Homo sapiens	IC50	>	15000.0	nM	PMID[24992071]
NPT81	Cell Line	A549	Homo sapiens	IC50	>	15000.0	nM	PMID[24992071]
NPT1161	Cell Line	CHO	Cricetulus griseus	IC50	>	20000.0	nM	PMID[24992071]
NPT2615	Cell Line	HEK-293T	Homo sapiens	IC50	>	20000.0	nM	PMID[24992071]
NPT169	Cell Line	B16-F10	Mus musculus	Activity	=	1.3	%	PMID[24992071]
NPT169	Cell Line	B16-F10	Mus musculus	Activity	=	3.7	%	PMID[24992071]
NPT169	Cell Line	B16-F10	Mus musculus	Activity	=	0.8	%	PMID[24992071]
NPT169	Cell Line	B16-F10	Mus musculus	Activity	=	94.1	%	PMID[24992071]
NPT83	Cell Line	MCF7	Homo sapiens	Activity	=	9.5	%	PMID[24992071]
NPT83	Cell Line	MCF7	Homo sapiens	Activity	=	5.9	%	PMID[24992071]
NPT83	Cell Line	MCF7	Homo sapiens	Activity	=	2.4	%	PMID[24992071]
NPT83	Cell Line	MCF7	Homo sapiens	Activity	=	82.8	%	PMID[24992071]
NPT1161	Cell Line	CHO	Cricetulus griseus	Activity	=	4.2	%	PMID[24992071]
NPT1161	Cell Line	CHO	Cricetulus griseus	Activity	=	0.0	%	PMID[24992071]
NPT1161	Cell Line	CHO	Cricetulus griseus	Activity	=	95.8	%	PMID[24992071]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Activity	=	0.4	%	PMID[24992071]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Activity	=	0.1	%	PMID[24992071]
NPT2615	Cell Line	HEK-293T	Homo sapiens	Activity	=	94.4	%	PMID[24992071]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	800.0	nM	PMID[25499882]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.0	nM	PMID[25516791]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.2	nM	PMID[24980053]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	Ki	=	778.0	nM	PMID[24980053]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[24980053]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[24980053]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.5	nM	PMID[24980053]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	6.9	nM	PMID[24980053]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	0.016	ug.mL-1	PMID[25113933]
NPT1182	Cell Line	J774.A1	Mus musculus	IC50	=	0.165	ug.mL-1	PMID[25113933]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	1.84	ug.mL-1	PMID[25113933]
NPT1182	Cell Line	J774.A1	Mus musculus	IC50	=	9.09	ug.mL-1	PMID[25113933]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	0.016	%	PMID[24909081]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	1.84	%	PMID[24909081]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.3	nM	PMID[25305688]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	8.0	nM	PMID[25338180]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	9.0	nM	PMID[25338180]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	2.0	nM	PMID[25338180]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	40.0	nM	PMID[25824662]
NPT1182	Cell Line	J774.A1	Mus musculus	IC50	=	400.0	nM	PMID[25824662]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	4700.0	nM	PMID[25824662]
NPT1182	Cell Line	J774.A1	Mus musculus	IC50	=	22000.0	nM	PMID[25824662]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.5	nM	PMID[25706100]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.8	nM	PMID[25706100]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	21.0	nM	PMID[25706100]
NPT1463	Individual Protein	Cytochrome P450 2J2	Homo sapiens	IC50	>	50000.0	nM	PMID[23033255]
NPT158	Individual Protein	Nuclear receptor subfamily 1 group I member 2	Rattus norvegicus	FC	=	4.0	n.a.	PMID[22019630]
NPT158	Individual Protein	Nuclear receptor subfamily 1 group I member 2	Rattus norvegicus	FC	=	5.0	n.a.	PMID[22019630]
NPT158	Individual Protein	Nuclear receptor subfamily 1 group I member 2	Rattus norvegicus	EC50	=	2600.0	nM	PMID[20966043]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	200.0	%	PMID[25978072]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	630.0	nM	PMID[26087384]
NPT113	Cell Line	RAW264.7	Mus musculus	Survival	=	91.0	%	PMID[26087384]
NPT113	Cell Line	RAW264.7	Mus musculus	Survival	=	100.0	%	PMID[26087384]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	800.0	nM	PMID[26305406]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.8	nM	PMID[26988801]
NPT1886	Cell Line	J774	Mus musculus	Inhibition	=	85.0	%	PMID[26915998]
NPT1886	Cell Line	J774	Mus musculus	Inhibition	=	90.0	%	PMID[26915998]
NPT1886	Cell Line	J774	Mus musculus	Inhibition	=	86.0	%	PMID[26915998]
NPT1886	Cell Line	J774	Mus musculus	Inhibition	=	38.0	%	PMID[26915998]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	9.6	%	PMID[27217003]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	1.7	%	PMID[27217003]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	6.1	nM	PMID[27810243]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	IC50	=	440.0	nM	PMID[27810243]
NPT153	Individual Protein	Androgen Receptor	Homo sapiens	IC50	>	20000.0	nM	PMID[27810243]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	40.0	nM	PMID[27810243]
NPT1459	Individual Protein	Glucocorticoid receptor	Mus musculus	FC	>	50.0	n.a.	PMID[27919657]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.8	nM	PMID[27876250]
NPT516	Individual Protein	TNF-alpha	Homo sapiens	Inhibition	=	49.9	%	PMID[27847171]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	84.9	%	PMID[27797185]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	80.4	%	PMID[27797185]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	75.9	%	PMID[27797185]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	86.1	%	PMID[27797185]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	79.2	%	PMID[27797185]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	71.8	%	PMID[27797185]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	7000.0	nM	PMID[28499733]
NPT612	Individual Protein	Canalicular multispecific organic anion transporter 1	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT1249	Individual Protein	Canalicular multispecific organic anion transporter 2	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT1028	Individual Protein	Multidrug resistance-associated protein 4	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT542	Individual Protein	Progesterone receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[28043796]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	12.59	nM	PMID[28043796]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	2.512	nM	PMID[28043796]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	7.943	nM	PMID[28043796]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.585	nM	PMID[28043796]
NPT153	Individual Protein	Androgen Receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[28043796]
NPT541	Individual Protein	Mineralocorticoid receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[28043796]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	55.6	%	PMID[28489375]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	55.0	%	PMID[28489375]
NPT81	Cell Line	A549	Homo sapiens	Activity	=	97.2	%	PMID[28489375]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Activity	=	35.7	%	PMID[28489375]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	800.0	nM	PMID[29272126]
NPT113	Cell Line	RAW264.7	Mus musculus	Survival	=	97.7	%	PMID[29272126]
NPT113	Cell Line	RAW264.7	Mus musculus	Survival	=	97.1	%	PMID[29272126]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	60.9	%	PMID[29359942]
NPT521	Cell Line	RBL-2H3	Rattus norvegicus	Inhibition	=	80.7	%	PMID[29381070]
NPT521	Cell Line	RBL-2H3	Rattus norvegicus	Inhibition	=	79.7	%	PMID[29381070]
NPT1618	Individual Protein	Peroxisome proliferator-activated receptor gamma	Mus musculus	FC	=	2.3	n.a.	PMID[29389121]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	8300.0	nM	PMID[29741372]
NPT34	Cell Line	BV-2	Mus musculus	IC50	=	9500.0	nM	PMID[29482940]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	2500.0	nM	PMID[28598633]
NPT1886	Cell Line	J774	Mus musculus	CC50	=	91100.0	nM	PMID[29523468]
NPT1886	Cell Line	J774	Mus musculus	Inhibition	=	69.8	%	PMID[29523468]
NPT4137	Cell Line	Splenocytes	Mus musculus	IC50	=	1.0	nM	PMID[29523468]
NPT1597	Cell Line	J774.2		Inhibition	=	62.0	%	PMID[29903412]
NPT1597	Cell Line	J774.2		Inhibition	=	40.0	%	PMID[29903412]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	10700.0	nM	PMID[29518326]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	40.0	%	PMID[29541375]
NPT1970	Cell Line	THP-1	Homo sapiens	Inhibition	=	58.0	%	PMID[29541375]
NPT1970	Cell Line	THP-1	Homo sapiens	Activity	=	0.0	%	PMID[29541375]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	2660.0	nM	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	100.2	%	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	2655.0	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	3219.4	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	3671.8	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	4056.3	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	3393.5	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	4063.6	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	4455.7	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	4810.1	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	6458.3	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	7533.7	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	8187.9	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	8748.1	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	269.5	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	332.8	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	393.4	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	422.7	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	791.0	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	927.7	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	1120.3	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	1240.5	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	924.1	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	1336.5	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	1594.9	pg/ml	PMID[30108912]
NPT113	Cell Line	RAW264.7	Mus musculus	Activity	=	1770.4	pg/ml	PMID[30108912]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	IC50	=	2.35	nM	PMID[30144697]
NPT4137	Cell Line	Splenocytes	Mus musculus	Inhibition	=	74.6	%	PMID[30293795]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	9400.0	nM	PMID[30579802]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	1200.0	nM	PMID[30579802]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	10.0	nM	PMID[30931559]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Kd	=	19.0	nM	PMID[31188592]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	EC50	=	0.1	nM	PMID[30359818]
NPT113	Cell Line	RAW264.7	Mus musculus	Inhibition	=	34.25	%	PMID[31550154]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	18400.0	nM	PMID[31181925]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Kd	=	2.0	nM	PMID[30929949]
NPT519	Cell Line	SH-SY5Y	Homo sapiens	Activity	=	16.0	%	PMID[30929949]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	5500.0	nM	PMID[31873014]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	5020.0	nM	PMID[31260892]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	159200.0	nM	PMID[31260892]
NPT113	Cell Line	RAW264.7	Mus musculus	Ratio IC50	=	31.9	n.a.	PMID[31260892]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	8700.0	nM	PMID[30528697]
NPT113	Cell Line	RAW264.7	Mus musculus	CC50	>	50000.0	nM	PMID[30528697]
NPT113	Cell Line	RAW264.7	Mus musculus	Ratio CC50/IC50	>	5.7	n.a.	PMID[30528697]
NPT1970	Cell Line	THP-1	Homo sapiens	FC	=	1.3	n.a.	PMID[30419493]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	10.0	nM	PMID[31301930]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	130.0	nM	PMID[30808589]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	6000.0	nM	PMID[31577434]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	8400.0	nM	PMID[31577434]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	6100.0	nM	PMID[31577434]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	7900.0	nM	PMID[30817151]
NPT2246	Cell Line	T-cells		IC50	=	1600.0	nM	PMID[31961677]
NPT1970	Cell Line	THP-1	Homo sapiens	IC50	=	2.512	nM	PMID[32631518]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	6.4	nM	PMID[32631518]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	4.3	nM	PMID[32631518]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	4.6	nM	PMID[32631518]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	3.8	nM	PMID[32631518]
NPT927	Cell Line	PBMC	Homo sapiens	IC50	=	2.3	nM	PMID[32631518]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	32500.0	nM	PMID[32070636]
NPT1886	Cell Line	J774	Mus musculus	IC50	=	5200.0	nM	PMID[32364737]
NPT1886	Cell Line	J774	Mus musculus	Inhibition	=	87.1	%	PMID[32364737]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	4160.0	nM	PMID[32738985]
NPT113	Cell Line	RAW264.7	Mus musculus	IC50	=	24300.0	nM	PMID[32935986]
NPT249	Individual Protein	Glucocorticoid receptor	Homo sapiens	Kd	=	2.8	nM	PMID[34046609]
NPT2142	Cell Line	REH	Homo sapiens	EC50	=	6.7	nM	PMID[34046609]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	95.0	%	PMID[9685237]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	42.0	%	PMID[15125973]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	35.0	%	PMID[15125973]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	41.0	%	PMID[15125973]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	16.0	%	PMID[15125973]
NPT2688	Organism	Sus scrofa	Sus scrofa	Inhibition	=	32.0	%	PMID[15125973]
NPT2688	Organism	Sus scrofa	Sus scrofa	Inhibition	=	35.0	%	PMID[15125973]
NPT2688	Organism	Sus scrofa	Sus scrofa	Inhibition	=	20.0	%	PMID[15125973]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	4.7	nM	PMID[10052971]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	3.5	nM	PMID[10052971]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	35800.0	nM	PMID[10579834]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	1000.0	nM	PMID[10579834]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED30	<	2.5	uM kg-1	DOI[10.1016/S0960-894X(01)81260-9]
NPT4866	Protein Family	Prostaglandin G/H synthase (cyclooxygenase)	Ovis aries	IC50	>	25000.0	nM	DOI[10.1016/S0960-894X(01)81260-9]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	99.0	%	PMID[15109623]
NPT605	Organism	Homo sapiens	Homo sapiens	Potency	=	1.0	n.a.	PMID[6827553]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Potency	=	200.0	n.a.	PMID[6827553]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	69.0	%	PMID[6094808]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	IC50	=	20.0	nM	PMID[12039573]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.12	mg.kg-1	PMID[12039573]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	95.0	%	PMID[8709136]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	0.1	nM	PMID[11909709]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	0.1	nM	PMID[10617085]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.3	cm	PMID[3494125]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	0.3	nM	PMID[9873608]
NPT32	Organism	Mus musculus	Mus musculus	ED50	>	100.0	ug ear-1	DOI[10.1016/S0960-894X(01)81022-2]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.5	ug ear-1	DOI[10.1016/S0960-894X(01)81022-2]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.7	ug ear-1	DOI[10.1016/S0960-894X(01)81022-2]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	0.1	nM	PMID[11063620]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	IC50	=	20.0	nM	PMID[12113803]
NPT27	Others	Unspecified		IC50	=	10.0	nM	PMID[11229767]
NPT27	Others	Unspecified		IC50	=	40.0	nM	PMID[11229767]
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	Activity	=	4.0	nM/mg*min	PMID[12699389]
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	Inhibition	=	0.0	%	PMID[12699389]
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	IC50	>	50000.0	nM	PMID[12699389]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	95.0	%	PMID[1995900]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	98.0	%	PMID[1995900]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	71.0	%	PMID[3681891]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	80.0	%	PMID[3681891]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	82.0	%	PMID[15454241]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	96.0	%	PMID[15454241]
NPT2	Others	Unspecified		IC50	=	7.943	nM	PMID[15999989]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.27	ug	PMID[16821781]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	71.0	%	PMID[16697190]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	54.0	%	PMID[16697190]
NPT27	Others	Unspecified		Activity	=	3.2	%	PMID[16789751]
NPT27	Others	Unspecified		Activity	<	1.0	%	PMID[16789751]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	42.0	%	PMID[17608466]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	44.0	%	PMID[17608466]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	14.0	%	PMID[17608466]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	62.0	%	PMID[17608466]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	36.0	%	PMID[17608466]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	-86.0	%	PMID[17095218]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	89.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	96.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	92.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	70.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	85.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	94.0	%	PMID[17467123]
NPT2	Others	Unspecified		Ratio	>	0.69	n.a.	PMID[15165136]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	72.0	%	PMID[19303290]
NPT2	Others	Unspecified		IC50	=	5.0	nM	PMID[19323483]
NPT27	Others	Unspecified		LD50	>	7100.0	nM	PMID[19323483]
NPT2	Others	Unspecified		Activity	>	80.0	%	PMID[19323483]
NPT20763	CELL-LINE	J774.1	Mus musculus	IC50	=	170000.0	nM	PMID[12608860]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	81.0	%	PMID[9392883]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	76.0	%	PMID[9392883]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	89.0	%	PMID[9392883]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	93.0	%	PMID[9392883]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	84.0	%	PMID[9392883]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	82.0	%	PMID[7760072]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	92.0	%	PMID[10217718]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.75	%	PMID[19362486]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	20.0	%	PMID[19362486]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	81.0	%	PMID[19362486]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	35.0	%	PMID[19362486]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	22.0	million	PMID[19394230]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	18.5	million	PMID[19394230]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1404.0	million	PMID[19394230]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.003	mg.kg-1	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	90.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	24.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	31.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	33.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	69.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	75.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	84.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	87.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	88.0	%	PMID[19425597]
NPT2	Others	Unspecified		Activity	=	0.13	%	PMID[19648015]
NPT74	Individual Protein	Proto-oncogene c-JUN	Homo sapiens	Activity	=	2.33	%	PMID[19648015]
NPT27	Others	Unspecified		Activity	=	0.0	%	PMID[20064725]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.54	%	PMID[20099827]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.77	%	PMID[20099827]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	68.0	%	PMID[20188549]
NPT605	Organism	Homo sapiens	Homo sapiens	Activity	=	0.8	%	PMID[20022146]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	24.0	%	PMID[20469868]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	67.0	%	PMID[20469868]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	88.0	%	PMID[20469868]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	83.0	%	PMID[20469868]
NPT27	Others	Unspecified		FC	=	0.4	n.a.	PMID[20469868]
NPT27	Others	Unspecified		FC	=	7.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified		FC	=	8.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified		FC	=	40.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified		FC	=	86.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified		FC	=	300.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified		FC	=	870.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified		FC	=	2944.0	n.a.	PMID[20469868]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	0.631	nM	PMID[20469868]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	0.5012	nM	PMID[20469868]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	0.3162	nM	PMID[20469868]
NPT27	Others	Unspecified		Activity	=	0.0	%	PMID[20430485]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	60.0	%	PMID[20666458]
NPT27	Others	Unspecified		Activity	=	0.0	%	PMID[20638287]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	90.0	%	PMID[20086156]
NPT312	Organism	Saccharomyces cerevisiae	Saccharomyces cerevisiae	IZ	=	9.0	mm	PMID[20739103]
NPT312	Organism	Saccharomyces cerevisiae	Saccharomyces cerevisiae	IZ	=	0.0	mm	PMID[20739103]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Inhibition	=	74.7	%	PMID[21473609]
NPT2	Others	Unspecified		Inhibition	=	61.6	%	PMID[21469695]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Inhibition	=	83.0	%	PMID[21766854]
NPT1308	Tissue	Blood	Homo sapiens	EC50	=	6.9	nM	PMID[21899328]
NPT1308	Tissue	Blood	Homo sapiens	EC50	=	5.1	nM	PMID[21899328]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	90.0	%	PMID[21916510]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	78.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	83.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	65.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	50.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	69.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	81.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	43.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	48.0	%	PMID[21469692]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	2.3	nM	PMID[22506620]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	63.0	%	PMID[22339472]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	83.0	%	PMID[24900359]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	FC	=	2.13	n.a.	PMID[22497764]
NPT433	Subcellular	Liver microsomes	Homo sapiens	Activity	=	445.0	pmol	PMID[22931300]
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	Activity	=	0.0	%	PMID[12699389]
NPT752	Individual Protein	Solute carrier organic anion transporter family member 1A1	Rattus norvegicus	Activity	=	26.0	%	PMID[8786566]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	102.0	%	PMID[22682057]
NPT72	Individual Protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Inhibition	=	34.2	%	PMID[22541068]
NPT73	Individual Protein	Solute carrier organic anion transporter family member 1B1	Homo sapiens	Inhibition	=	10.7	%	PMID[22541068]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	70.0	%	PMID[22924688]
NPT27	Others	Unspecified		Activity	=	0.0	%	DOI[10.1007/s00044-011-9856-1]
NPT27	Others	Unspecified		Activity	=	0.0	%	DOI[10.1007/s00044-011-9834-7]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	40.0	%	DOI[10.1007/s00044-009-9190-z]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	30.0	%	DOI[10.1007/s00044-009-9190-z]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	23.0	%	DOI[10.1007/s00044-009-9190-z]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	89.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	87.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	71.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	45.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	33.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	29.0	%	DOI[10.1007/s00044-012-0406-2]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Activity	=	20.0	%	PMID[23758110]
NPT72	Individual Protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Inhibition	=	103.89	%	PMID[23571415]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	17.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	25.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	30.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	53.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	76.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	16.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	28.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	34.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	49.0	%	PMID[71349]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	>	20000.0	nM	PMID[24992071]
NPT27	Others	Unspecified		IC50	>	15000.0	nM	PMID[24992071]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	83.0	%	PMID[25479567]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	97.0	%	PMID[25479567]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Inhibition	=	45.0	%	PMID[25102418]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Inhibition	=	88.0	%	PMID[25102418]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Activity	=	1.14	mg/ml	PMID[25102418]
NPT24057	SINGLE PROTEIN	Transcription factor AP-1	Mus musculus	Ratio	=	2.33	n.a.	PMID[24831826]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Inhibition	=	0.165	%	PMID[24909081]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Inhibition	=	9.09	%	PMID[24909081]
NPT2	Others	Unspecified		IC50	=	610.0	nM	PMID[24938495]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	100.0	%	PMID[25690784]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	73.4	%	PMID[25824662]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	62.5	%	PMID[25824662]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	18.46	%	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	4.49	%	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	11.8	%	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	0.76	micrometer/day	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	6.58	10'9/L	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	25.77	%	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	53.03	%	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	213.0	U/L	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	63.64	U/L	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1.63	mmol/L	PMID[25874339]
NPT712	Individual Protein	Bile salt export pump	Rattus norvegicus	IC50	=	231900.0	nM	PMID[21965623]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	=	137400.0	nM	PMID[21965623]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	70.5	%	PMID[26110443]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	25.0	nM	PMID[26110443]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	506.3	mg/cm3	DOI[10.1039/C5MD00215J]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Inhibition	=	48.0	%	PMID[27227459]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Inhibition	=	42.0	%	PMID[27227459]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	630.0	nM	PMID[27825545]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	91.0	%	PMID[27825545]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	100.0	%	PMID[27825545]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	>	135000.0	nM	PMID[20829430]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1.6	%	PMID[28410442]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	6.7	ng/mg	PMID[28410442]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	2.2	pg/mg	PMID[28410442]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	=	101700.0	nM	PMID[22961681]
NPT2	Others	Unspecified		Activity	=	100.0	pg/ml	PMID[28799755]
NPT862	Individual Protein	Epoxide hydratase	Homo sapiens	Inhibition	=	59.4	%	PMID[28845983]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	86.0	%	PMID[28501511]
NPT713	Individual Protein	Bile salt export pump	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	0.03	U/L	PMID[28613871]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	65.0	%	PMID[28689977]
NPT2	Others	Unspecified		IC50	=	7.8	nM	PMID[30108696]
NPT26631	CELL-LINE	Multiple myeloma cancer stem cell	n.a.	IC50	>	100000.0	nM	PMID[30108696]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	59.0	%	PMID[30106292]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	10.1	%	PMID[30106292]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	43.0	%	PMID[30106292]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	90.0	%	PMID[30193941]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	59.2	g	PMID[29395981]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	91.0	%	PMID[30114661]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	51.0	%	PMID[31272795]
NPT21752	CELL-LINE	Peritoneal macrophage cells	n.a.	IC50	=	150.0	nM	PMID[31358465]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	46.8	%	PMID[31299586]
NPT26694	SINGLE PROTEIN	Lipoxin A4 receptor	Homo sapiens	Activity	=	53.2	%	PMID[30419493]
NPT2	Others	Unspecified		Activity	=	1.6	%	PMID[30419493]
NPT26694	SINGLE PROTEIN	Lipoxin A4 receptor	Homo sapiens	Activity	=	13.6	%	PMID[30419493]
NPT26694	SINGLE PROTEIN	Lipoxin A4 receptor	Homo sapiens	Activity	=	1.5	%	PMID[30419493]
NPT26694	SINGLE PROTEIN	Lipoxin A4 receptor	Homo sapiens	Activity	=	62.6	%	PMID[30419493]
NPT26694	SINGLE PROTEIN	Lipoxin A4 receptor	Homo sapiens	Activity	=	45.1	%	PMID[30419493]
NPT26694	SINGLE PROTEIN	Lipoxin A4 receptor	Homo sapiens	Activity	=	58.1	%	PMID[30419493]
NPT2	Others	Unspecified		Inhibition	=	82.5	%	PMID[31473042]
NPT2	Others	Unspecified		IC50	=	134.0	nM	PMID[31473042]
NPT20	Organism	Candida albicans	Candida albicans	Inhibition	=	1.68	%	DOI[10.6019/CHEMBL4296181]
NPT85	Organism	Filobasidiella neoformans	Cryptococcus neoformans	Inhibition	=	-1.2	%	DOI[10.6019/CHEMBL4296181]
NPT19	Organism	Escherichia coli	Escherichia coli	Inhibition	=	5.83	%	DOI[10.6019/CHEMBL4296181]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	Inhibition	=	-0.78	%	DOI[10.6019/CHEMBL4296181]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	Inhibition	=	2.35	%	DOI[10.6019/CHEMBL4296181]
NPT747	Organism	Acinetobacter baumannii	Acinetobacter baumannii	Inhibition	=	8.59	%	DOI[10.6019/CHEMBL4296181]
NPT2922	Organism	Staphylococcus aureus subsp. aureus	Staphylococcus aureus subsp. aureus	Inhibition	=	-14.23	%	DOI[10.6019/CHEMBL4296181]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	45.0	%	PMID[32150408]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	72.0	%	PMID[32150408]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	82.0	%	PMID[32150408]
NPT2	Others	Unspecified		EC50	=	7.943	nM	PMID[32631518]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	45.0	%	PMID[32676146]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	37.0	%	PMID[32676146]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	20000.0	nM	DOI[10.6019/CHEMBL4651402]
NPT20555	ORGANISM	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	19952.62	nM	DOI[10.6019/CHEMBL4651402]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.53	mm	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	2.32	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.63	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	2.17	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.86	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.99	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.39	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.5	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	2.96	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.85	pg	PMID[30905542]
NPT27	Others	Unspecified		Activity	=	92.74	%	PMID[30905542]
NPT2	Others	Unspecified		Activity	=	65.0	%	PMID[33264011]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	17.19	g	PMID[31881455]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	79.1	%	PMID[27713015]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	72.9	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	40.9	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	30.6	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	66.9	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	75.1	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	46.1	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	55.9	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	58.7	%	PMID[33360197]
NPT27233	SINGLE PROTEIN	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	Homo sapiens	Activity	=	172.36	%	PMID[28448136]
NPT27233	SINGLE PROTEIN	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	Homo sapiens	FC	=	2.0	n.a.	PMID[28448136]
NPT27699	CELL-LINE	B-cell line	Mus musculus	IC50	=	800.0	nM	PMID[31961677]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC331613 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	197
0.1-0.2	1306
0.2-0.3	5291
0.3-0.4	11746
0.4-0.5	10015
0.5-0.6	6411
0.6-0.7	5633
0.7-0.8	1843
0.8-0.85	203
0.85-0.9	41
0.9-0.95	7
0.95-1	4

Similarity Score	Similarity Level	Natural Product ID

Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC331613 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	163
0.1-0.2	1521
0.2-0.3	4096
0.3-0.4	2295
0.4-0.5	603
0.5-0.6	151
0.6-0.7	140
0.7-0.8	72
0.8-0.85	31
0.85-0.9	28
0.9-0.95	36
0.95-1	14

Similarity Score	Similarity Level	Drug ID	Developmental Stage

Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data