NPASS Compound

Natural Product: NPC331613

Natural Product ID	NPC331613
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	UREBDLICKHMUKA-CXSFZGCWSA-N
IUPAC Name	n.a.
Synonyms
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	n.a.
PubChem CID	5743
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000012] Lipids and lipid-like molecules [CHEMONTID:0000258] Steroids and steroid derivatives [CHEMONTID:0001295] Hydroxysteroids [CHEMONTID:0003095] 21-hydroxysteroids

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 57 60 0 0 0 0 0 0 0 0999 V2000 3.6190 0.4038 -2.1390 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8174 -0.6188 -1.3591 C 0 0 2 0 0 0 0 0 0 0 0 0 1.3997 -0.5910 -1.9538 C 0 0 0 0 0 0 0 0 0 0 0 0 0.6390 0.0654 -0.8678 C 0 0 1 0 0 0 0 0 0 0 0 0 -0.8237 -0.1256 -0.8372 C 0 0 2 0 0 0 0 0 0 0 0 0 -1.4084 0.3413 -2.1539 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.8860 0.0880 -2.0838 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4714 0.4367 -0.7597 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.6419 1.0337 -0.7657 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.3488 1.4397 0.4434 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.4692 2.0102 0.4175 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.6508 1.1305 1.6871 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.4747 0.5338 1.7197 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.7636 0.1312 0.5255 C 0 0 1 0 0 0 0 0 0 0 0 0 -2.6997 -1.4126 0.5842 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.3905 0.7054 0.3258 C 0 0 1 0 0 0 0 0 0 0 0 0 -0.4706 0.8946 1.4201 C 0 0 2 0 0 0 0 0 0 0 0 0 0.6418 -0.1178 1.5991 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2217 -0.6375 0.3452 C 0 0 1 0 0 0 0 0 0 0 0 0 1.1601 -2.1277 0.2642 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6786 -0.2510 0.0980 C 0 0 1 0 0 0 0 0 0 0 0 0 3.6124 -0.9368 0.9818 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7500 -2.1493 1.0497 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5072 -0.1507 1.9094 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3129 1.2015 1.7933 O 0 0 0 0 0 0 0 0 0 0 0 0 2.7728 1.1063 0.2669 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.9747 1.1285 2.6889 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.6368 1.9615 -0.2736 F 0 0 0 0 0 0 0 0 0 0 0 0 3.9477 -0.1083 -3.0913 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0007 1.2591 -2.4811 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5503 0.7003 -1.6345 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3056 -1.5949 -1.5228 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0394 -1.6515 -2.0486 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3753 -0.0679 -2.9143 H 0 0 0 0 0 0 0 0 0 0 0 0 0.9310 1.1271 -0.7946 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.0793 -1.1864 -0.7576 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.1594 1.4186 -2.2578 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.9183 -0.2400 -2.9437 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.0439 -0.9990 -2.2312 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.4136 0.5971 -2.9129 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.1170 1.2394 -1.7448 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.1543 1.4206 2.6128 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.0794 0.3509 2.7035 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.5010 -1.8056 1.2822 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.9271 -1.8731 -0.3774 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.7571 -1.7171 1.0659 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1230 1.8548 1.2321 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2985 -0.9804 2.2114 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4835 0.3241 2.1897 H 0 0 0 0 0 0 0 0 0 0 0 0 1.9420 -2.5830 -0.3739 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3861 -2.5051 1.3058 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2086 -2.5679 -0.0130 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5692 -0.3659 1.6541 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2876 -0.4364 2.9752 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9016 1.6587 1.1543 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1388 1.6101 -0.4765 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.3604 1.6284 3.2626 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 1 0 4 5 1 0 5 6 1 0 6 7 1 0 7 8 1 0 8 9 2 0 9 10 1 0 10 11 2 0 10 12 1 0 12 13 2 0 13 14 1 0 14 15 1 1 14 16 1 0 16 17 1 0 17 18 1 0 18 19 1 0 19 20 1 6 19 21 1 0 21 22 1 0 22 23 2 0 22 24 1 0 24 25 1 0 21 26 1 6 17 27 1 0 16 28 1 6 21 2 1 0 19 4 1 0 16 5 1 0 14 8 1 0 1 29 1 0 1 30 1 0 1 31 1 0 2 32 1 1 3 33 1 0 3 34 1 0 4 35 1 1 5 36 1 1 6 37 1 0 6 38 1 0 7 39 1 0 7 40 1 0 9 41 1 0 12 42 1 0 13 43 1 0 15 44 1 0 15 45 1 0 15 46 1 0 17 47 1 6 18 48 1 0 18 49 1 0 20 50 1 0 20 51 1 0 20 52 1 0 24 53 1 0 24 54 1 0 25 55 1 0 26 56 1 0 27 57 1 0 M END

Standard InCHIKey	UREBDLICKHMUKA-CXSFZGCWSA-N
Standard InCHI	InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
SMILES	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@]3([C@H](C[C@]2(C)[C@]1(C(=O)CO)O)O)F

Calculated Properties

Physi-Chem Properties

Molecular Weight:	392.2	Volume:	394.315 ? Van der Waals volume.
Dense:	0.995	LogP:	1.321 ? The logarithm of the n-octanol/water distribution coefficients.
logD7.4:	1.779 ? The logarithm of the n-octanol/water distribution coefficient at pH=7.4.	LogS:	-3.509 ? The logarithm of aqueous solubility value.
Rotatable Bonds:	2.0	Rigid Bonds:	22.0
TPSA:	94.83 ? Topological Polar Surface Area.	H-Bond Acceptor:	5.0
H-Bond Donor:	3.0	Rings:	4.0
Heavy Atoms:	6.0

MedChem Properties

QED Drug-Likeness Score:	0.667	GASA:	1.0 ? GASA represents the probability of being difficult to synthesize, ranging from 0 to 1.
Synthetic Accessibility Score:	4.635	Fsp³:	0.727
MCE-18:	81.579 ? MCE-18 stands for medicinal chemistry evolution.MCE-18≥45 is considered a suitable value.	Lipinski Rule-of-5:	Rejected
Pfizer Rule:	Rejected	GSK Rule:	Rejected
Golden Triangle Rule:	Rejected	BMS Rule:	0
Chelating Alert:	0	PAINS Alert:	0
Colloidal aggregators:	0.36	Fluc inhibitor:	0.045 ? The fluc inhibitor value is the probability of being fLuc inhibitors, within the range of 0 to 1.
Blue fluorescence:	0.014 ? The blue fluorescence value is the probability of being blue fluorescence, within the range of 0 to 1	Green fluorescence:	0.0 ? The green fluorescence value is the probability of being green fluorescence, within the range of 0 to 1
Reactive compounds:	0.267	Promiscuous compounds:	0.985

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

Caco-2 Permeability:	-4.911	MDCK Permeability:	-4.715
Pgp-inhibitor:	0.187	Pgp-substrate:	0.101
PAMPA:	0.325 ? The experimental data for Peff was logarithmically transformed (logPeff). Molecules with log Peff values below 2.0 were classified as low-permeability (Category 0), while those with log Peff values exceeding 2.5 were classified as high-permeability (Category 1).	Human Intestinal Absorption (HIA):	0.0
20% Bioavailability (F20%):	0.013	30% Bioavailability (F30%):	0.022
50% Bioavailability (F50%):	0.816

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.991	MRP1:	0.85
Plasma Protein Binding (PPB):	70.678%	Volume Distribution (VD):	-0.002
Fu:	28.219% ? The fraction unbound in plasms.	OATP1B1 inhibitor:	0.926
OATP1B3 inhibitor:	0.978	BCRP inhibitor:	0.199
BSEP inhibitor:	0.996

ADMET: Metabolism

CYP1A2-inhibitor:	0.0	CYP1A2-substrate:	0.0
CYP2C19-inhibitor:	0.01	CYP2C19-substrate:	0.007
CYP2C9-inhibitor:	0.0	CYP2C9-substrate:	0.0
CYP2D6-inhibitor:	0.0	CYP2D6-substrate:	0.307
CYP3A4-inhibitor:	1.0	CYP3A4-substrate:	0.018
CYP2B6-substrate:	0.0	CYP2C8-inhibitor:	1.0
HLM stability:	0.004 ? Human liver microsomal (HLM) stability. Category 0: stable+ (HLM > 30 min); Category 1: unstable- (HLM ≤ 30 min). The output value is the probability of human liver microsomal instability, where a value closer to 1 indicates a higher likelihood of instability.

ADMET: Excretion

Clearance (CL):

2.677

Half-life (T1/2):

2.43

ADMET: Toxicity

hERG Blockers:	0.04	hERG Blockers (10um):	0.102
Human Hepatotoxicity (H-HT):	0.501	Drug-induced Liver Injury (DILI):	0.01
AMES Toxicity:	0.102	Rat Oral Acute Toxicity:	0.822
Maximum Recommended Daily Dose:	0.999	Skin Sensitization:	0.766
Carcinogencity:	0.515	Eye Corrosion:	0.001
Eye Irritation:	0.472	Respiratory Toxicity:	0.986
Drug-induced Neurotoxicity:	0.088	Ototoxicity:	0.85
Hematotoxicity:	0.064	Drug-induced Nephrotoxicity:	0.465
Genotoxicity:	0.987	RPMI-8226 Immunitoxicity:	0.329
A549 Cytotoxicity:	0.0	Hek293 Cytotoxicity:	0.104
BCF:	0.661 ? Bioconcentration factors are used for considering secondary poisoning potential and assessing risks to human health via the food chain. The unit is -log10[(mg/L)/(1000*MW)].	IGC50:	3.357 ? 48 hour Tetrahymena pyriformis IGC50. The unit of IGC50 is -log10[(mg/L)/(1000*MW)].
LC50DM:	4.994 ? 48 hour Daphnia magna LC50. The unit of LC50DM is -log10[(mg/L)/(1000*MW)].	LC50FM:	4.269 ? 96 hour fathead minnow LC50. The unit of LC50FM is -log10[(mg/L)/(1000*MW)].

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	seed	n.a.	DOI[10.1016/0031-9422(96)00258-0]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Anhui province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Gansu province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Henan province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Shandong province, China		DOI[10.1016/j.foodres.2020.109416]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Shanxi province, China		DOI[10.1016/j.foodres.2020.109416]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	fruit	n.a.	DOI[10.1016/S1383-5769(99)00023-9]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	DOI[10.2174/092986712800229032]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[10086989]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	seeds	n.a.	n.a.	PMID[11087592]
NPO29042	Vincetoxicum atratum	Species	Apocynaceae	Eukaryota	Roots	n.a.	n.a.	PMID[11374953]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[12542364]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	stem bark	Indonesia	1999-SEP	PMID[14510596]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	n.a.	stem	n.a.	PMID[14510596]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[1512598]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	Seeds	n.a.	n.a.	PMID[15165151]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	seeds	n.a.	n.a.	PMID[15730242]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	bark	n.a.	PMID[1593281]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	flowers	n.a.	n.a.	PMID[15974620]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	fruit	n.a.	PMID[16268506]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[16309313]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	root	n.a.	PMID[16564530]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17580910]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	fruit	Indonesia	n.a.	PMID[17896817]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[18321057]
NPO3821	Sinularia flexibilis	Species	Alcyoniidae	Eukaryota	n.a.	chinese soft coral	n.a.	PMID[18553926]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	Vietnam	n.a.	PMID[19026551]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	whole plant	n.a.	PMID[19099222]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[19402674]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[19721258]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[19772486]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	seeds	n.a.	n.a.	PMID[20050684]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Roots	n.a.	n.a.	PMID[20806783]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[21782011]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21893415]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21954931]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[22190295]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	Seeds	n.a.	n.a.	PMID[22506620]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[22703163]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23270478]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	seed	n.a.	PMID[23497864]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[24328283]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	aerial part	n.a.	PMID[24704554]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25396337]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	dry stem	n.a.	n.a.	PMID[25466192]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	Roots	n.a.	n.a.	PMID[26599832]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[26838074]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27295506]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[27313650]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	root	n.a.	PMID[27429639]
NPO4734	Syzygium nervosum	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27797185]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28448136]
NPO40871	Laserpitium zernyi	Species	n.a.	n.a.	n.a.	n.a.	n.a.	PMID[28489375]
NPO27950	Aspergillus ochraceopetaliformis	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28598633]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[28617598]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	Leaves	n.a.	n.a.	PMID[29272126]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	Roots	n.a.	n.a.	PMID[29359942]
NPO40105	Dietes bicolor	Species	Iridaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29381070]
NPO40980	Penicillium chrysogenum J08NF-4	Strain	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29389121]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	Roots	n.a.	n.a.	PMID[29482940]
NPO40028	Artemisia freyniana	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[29518326]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Roots	n.a.	n.a.	PMID[29741372]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30028612]
NPO40356	Spondias pinnata	Species	Anacardiaceae	Eukaryota	Bark	n.a.	n.a.	PMID[30215255]
NPO3821	Sinularia flexibilis	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	PMID[30528697]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30649869]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30724086]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30817151]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[30931559]
NPO40479	Colletotrichum sp. S8.	Strain	Glomerellaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31181925]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	Fruits	n.a.	n.a.	PMID[31301930]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31550154]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31577434]
NPO14563	Kalimeris shimadae	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31804830]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	Rhizomes	n.a.	n.a.	PMID[31873014]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	Roots	n.a.	n.a.	PMID[31944695]
NPO40401	Xylaria longipes	Species	Xylariaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[31961677]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	Whole Fruits	n.a.	n.a.	PMID[32159343]
NPO40847	Evolvulus linarioides	Species	n.a.	n.a.	Aerial Parts	n.a.	n.a.	PMID[32364737]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	HeZe, ShanDong, China	early autumn (from August to the beginning of September	PMID[32545196]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32935986]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Roots	n.a.	n.a.	PMID[32951423]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	Seeds	Xinjiang,China		PMID[33063333]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[33264011]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[6481366]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[7561896]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	Roots; Tubers	n.a.	n.a.	PMID[7714535]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	seeds	n.a.	n.a.	PMID[8676130]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[8946743]
NPO3821	Sinularia flexibilis	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	PMID[9644083]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[Article]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[Article]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3821	Sinularia flexibilis	Species	Alcyoniidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14563	Kalimeris shimadae	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO29042	Vincetoxicum atratum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO40980	Penicillium chrysogenum J08NF-4	Strain	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO40401	Xylaria longipes	Species	Xylariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO27950	Aspergillus ochraceopetaliformis	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO40479	Colletotrichum sp. S8.	Strain	Glomerellaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO30165	Pongamia pinnata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29042	Vincetoxicum atratum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO26657	Conocephalum conicum	Species	Conocephalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO29417	Fallopia multiflora	Species	Polygonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO29042	Vincetoxicum atratum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO29530	Kaempferia marginata	Species	Zingiberaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO22224	Caragana jubata	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14948	Brucea javanica	Species	Simaroubaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO29042	Vincetoxicum atratum	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4734	Syzygium nervosum	Species	Myrtaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO520	Euphorbia lathyris	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28688	Aster tataricus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO23548	Leonurus heterophyllus	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO14563	Kalimeris shimadae	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9798	Paeonia lactiflora	Species	Paeoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12682	Euphorbia helioscopia	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO8622	Stauntonia hexaphylla	Species	Lardizabalaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO27950	Aspergillus ochraceopetaliformis	Species	Aspergillaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7697	Asimina triloba	Species	Annonaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO17799	Siraitia grosvenorii	Species	Cucurbitaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO28734	Physalis peruviana	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
IC50	250
Ki	22
Activity	289
Inhibition	211
Ratio	8
EC50	75
ED50	7
Kd	4
FC	19
AC50	68
Emax	5
%max	5
%Inhib (Mean)	49
Efficacy	2
%Max (Mean)	13
IZ	2
Ratio IC50	1
Ratio CC50/IC50	1
Imax	5
Control DMSO Mitochondria Different-Phenotype Cell	53
Control DMSO Fragmented Nuclei %	51
Control DMSO Healthy Nuclei (%)	50
Population Mitotic Cells (%)	50
Control DMSO Total Cells	52
Population Healthy Nuclei (%)	50
Population Tubulin-Different-Phenotype (%)	51
Population Mitochondria Different-Phenotype (%)	49
Total Cell Count	49
Population Membrane Permeable-Phenotype (%)	50
Population Pyknosed Nuclei (%)	49
Population Normal (%)	49
Population Fragmented Nuclei (%)	50
Control DMSO Mitotic Cells (%)	49
Population Hoechst High Intensity Objects (%)	49
Control DMSO Tubulin Phenotype Different Cells (%)	49
Control DMSO Pyknosed Nuclei (%)	48
Control DMSO Membrane Permeable-Phenotype Cells (%	48
Growth Rate	11
Population Apoptotic (%)	48
CC50	4
ED30	1
Potency	2
Survival	8

Activity Type	# Activity
Individual protein	351
Cell line	1279
Single protein	33
Organism	271
Subcellular	1
Unchecked	19
Protein family	1
Others	35
Non-molecular	14
Tissue	2

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT183	Individual protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	>	25000.0	nM	DOI[10.1016/S0960-894X(01)81260-9]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	5.5	nM	PMID[8627601]
NPT2945	Individual protein	Phospholipase A2 group 1B	Sus scrofa	IC50	>	750000.0	nM	DOI[10.1016/S0960-894X(01)81022-2]
NPT183	Individual protein	Arachidonate 5-lipoxygenase	Rattus norvegicus	IC50	=	120000.0	nM	DOI[10.1016/S0960-894X(01)81022-2]
NPT109	Individual protein	Cytochrome P450 3A4	Homo sapiens	IC50	>	50000.0	nM	PMID[12699389]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	IC50	>	50000.0	nM	PMID[12699389]
NPT1456	Individual protein	P-glycoprotein 1	Mus musculus	IC50	>	50000.0	nM	PMID[12699389]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	Ratio	=	0.8	n.a.	PMID[12699389]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	Ratio	=	2.3	n.a.	PMID[12699389]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	Ratio	=	5.2	n.a.	PMID[12699389]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	<	10000.0	nM	PMID[15999989]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.0	nM	PMID[16112571]
NPT299	Individual protein	Androgen Receptor	Rattus norvegicus	IC50	=	81283.05	nM	PMID[16134935]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	5.012	nM	PMID[16821781]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	>	10000.0	nM	PMID[16821781]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.175	nM	PMID[16821781]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	7.943	nM	PMID[16821781]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[17181172]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	0.2	nM	PMID[17705362]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.4	nM	PMID[17705362]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	2.1	nM	PMID[17705362]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.4	nM	PMID[17118655]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	7.586	nM	PMID[17616395]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.0	nM	PMID[17616395]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	102.0	%	PMID[17616395]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	5.37	nM	PMID[17616395]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	<	1000.0	nM	PMID[17616395]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Inhibition	=	7.0	%	PMID[17616395]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[17692519]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	7.943	nM	PMID[18038970]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	5.012	nM	PMID[18038970]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.175	nM	PMID[18038970]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	110.0	%	PMID[18038970]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	102.0	%	PMID[18038970]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	>	10000.0	nM	PMID[18038970]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	ED50	=	0.1	nM	PMID[18032610]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ratio	=	2.56	n.a.	PMID[18177009]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	5.0	nM	PMID[18490170]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	5.0	nM	PMID[18412397]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	3.0	nM	PMID[18983139]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	6.0	nM	PMID[18983139]
NPT3031	Individual protein	Estrogen receptor alpha	Rattus norvegicus	Activity	=	0.0	%	PMID[18472187]
NPT299	Individual protein	Androgen Receptor	Rattus norvegicus	Activity	=	0.0	%	PMID[18472187]
NPT3036	Individual protein	Progesterone receptor	Rattus norvegicus	Activity	=	0.0	%	PMID[18472187]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	Activity	=	66.0	%	PMID[18472187]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.1	nM	PMID[19321341]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[19321341]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[19321341]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.2	nM	PMID[19321341]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ratio	=	1.99	n.a.	PMID[17067160]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.0	nM	PMID[16643060]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	5.0	nM	PMID[19610652]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.0	nM	PMID[19592247]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.2	nM	PMID[20047280]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[20047280]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[20047280]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.5	nM	PMID[20047280]
NPT153	Individual protein	Androgen Receptor	Homo sapiens	IC50	>	4000.0	nM	PMID[20047280]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	7.2	nM	PMID[19863083]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.1	nM	PMID[20334371]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	87.0	%	PMID[20334371]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	11.4	nM	PMID[20334371]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Kd	=	19.0	nM	PMID[20355713]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	100.0	%	PMID[20427184]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	50.0	%	PMID[20427184]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	0.51	nM	PMID[20735001]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.4	nM	PMID[20735001]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	<	15848.93	nM	PMID[20812681]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	0.5082	nM	PMID[20812681]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	7.943	nM	PMID[20727743]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	12.59	nM	PMID[20727743]
NPT153	Individual protein	Androgen Receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[20727743]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	2.512	nM	PMID[20727743]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.585	nM	PMID[20727743]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	5.0	nM	PMID[20875743]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	12.59	nM	PMID[21257309]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.0	nM	PMID[21257309]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	102.0	%	PMID[21257309]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.981	nM	PMID[21257309]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	99.0	%	PMID[21257309]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	IC50	=	22.0	nM	PMID[21349712]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.1	nM	PMID[21073190]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[21073190]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[21073190]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.2	nM	PMID[21073190]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	5.0	nM	PMID[21073190]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	IC50	=	22.0	nM	PMID[21944856]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[21963986]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	0.51	nM	PMID[21963986]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.8	nM	PMID[21963986]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	17.0	nM	PMID[21963986]
NPT1733	Individual protein	Solute carrier organic anion transporter family member 1A2	Homo sapiens	Inhibition	=	97.3	%	PMID[9539145]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	FC	=	10.0	n.a.	PMID[21800856]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	9.7	nM	PMID[23199485]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	12.5	nM	PMID[23199485]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	3.7	nM	PMID[23199485]
NPT3087	Individual protein	Transcription factor p65	Mus musculus	Activity	=	100.0	%	PMID[23219855]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	2.5	nM	PMID[23582449]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	2.2	nM	PMID[23403082]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	4.1	nM	PMID[23403082]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Inhibition	=	21.0	%	PMID[23403082]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.5	nM	PMID[23466604]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[23466604]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.2	nM	PMID[24011644]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[24011644]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.1	nM	PMID[24011644]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.5	nM	PMID[23916594]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[23916594]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[23916594]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.2	nM	PMID[23916594]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.5	nM	PMID[23953070]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[23953070]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.2	nM	PMID[23953070]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[23953070]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.5	nM	PMID[24215891]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	0.5	nM	PMID[24215891]
NPT153	Individual protein	Androgen Receptor	Homo sapiens	Ki	=	1410.0	nM	PMID[24446728]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	0.69	nM	PMID[24446728]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[24656565]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	0.5	nM	PMID[24656565]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	17.0	nM	PMID[24656565]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.0	nM	PMID[25516791]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	1.2	nM	PMID[24980053]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	2.5	nM	PMID[24980053]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.1	nM	PMID[24980053]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	4.5	nM	PMID[24980053]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	6.9	nM	PMID[24980053]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	1.3	nM	PMID[25305688]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.5	nM	PMID[25706100]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.8	nM	PMID[25706100]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	21.0	nM	PMID[25706100]
NPT1463	Individual protein	Cytochrome P450 2J2	Homo sapiens	IC50	>	50000.0	nM	PMID[23033255]
NPT158	Individual protein	Nuclear receptor subfamily 1 group I member 2	Rattus norvegicus	FC	=	4.0	n.a.	PMID[22019630]
NPT158	Individual protein	Nuclear receptor subfamily 1 group I member 2	Rattus norvegicus	FC	=	5.0	n.a.	PMID[22019630]
NPT158	Individual protein	Nuclear receptor subfamily 1 group I member 2	Rattus norvegicus	EC50	=	2600.0	nM	PMID[20966043]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	200.0	%	PMID[25978072]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.8	nM	PMID[26988801]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	6.1	nM	PMID[27810243]
NPT153	Individual protein	Androgen Receptor	Homo sapiens	IC50	>	20000.0	nM	PMID[27810243]
NPT1459	Individual protein	Glucocorticoid receptor	Mus musculus	FC	>	50.0	n.a.	PMID[27919657]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.8	nM	PMID[27876250]
NPT1249	Individual protein	Canalicular multispecific organic anion transporter 2	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT1028	Individual protein	Multidrug resistance-associated protein 4	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	12.59	nM	PMID[28043796]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	2.512	nM	PMID[28043796]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	7.943	nM	PMID[28043796]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	1.585	nM	PMID[28043796]
NPT153	Individual protein	Androgen Receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[28043796]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	55.6	%	PMID[28489375]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	55.0	%	PMID[28489375]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	=	35.7	%	PMID[28489375]
NPT1618	Individual protein	Peroxisome proliferator-activated receptor gamma	Mus musculus	FC	=	2.3	n.a.	PMID[29389121]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	2.35	nM	PMID[30144697]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Kd	=	19.0	nM	PMID[31188592]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	0.1	nM	PMID[30359818]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Kd	=	2.0	nM	PMID[30929949]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Kd	=	2.8	nM	PMID[34046609]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	Emax	=	85.5	%	PMID[34676039]
NPT216	Individual protein	Adenosine A1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	%max	=	113.0	%	PMID[36105346]
NPT263	Individual protein	Muscarinic acetylcholine receptor M2	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	AC50	=	1.9	nM	PMID[37468498]
NPT299	Individual protein	Androgen Receptor	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	=	2900.0	nM	PMID[36379105]
NPT267	Individual protein	Neuropeptide Y receptor type 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1464	Individual protein	Phosphodiesterase 4D	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT252	Individual protein	Histamine H2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT3172	Individual protein	Phospholipase A2 group IIA	Homo sapiens	IC50	=	590.0	nM	PMID[36325400]
NPT243	Individual protein	Dopamine D2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT31	Individual protein	Cyclooxygenase-2	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1410	Individual protein	GABA receptor alpha-1 subunit	Rattus norvegicus	AC50	>	10000.0	nM	PMID[37468498]
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	%Inhib (Mean)	=	17.89	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	%max	=	100.0	%	PMID[36105346]
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	%Inhib (Mean)	=	-44.32	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Inhibition	n.a.	n.a.	%	PMID[36399795]
NPT246	Individual protein	Dopamine transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT259	Individual protein	Melanocortin receptor 4	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	3.0	nM	PMID[36399795]
NPT1109	Individual protein	Apelin receptor	Homo sapiens	%Inhib (Mean)	=	3.55	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	%Inhib (Mean)	=	1.23	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT239	Individual protein	Cholecystokinin A receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1109	Individual protein	Apelin receptor	Homo sapiens	%Inhib (Mean)	=	49.02	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	%Inhib (Mean)	=	-6.33	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT251	Individual protein	Histamine H1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	Efficacy	=	103.3	%	PMID[34676039]
NPT2879	Individual protein	Equilibrative nucleoside transporter 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT270	Individual protein	Nitric oxide synthase, inducible	Mus musculus	IC50	>	10000.0	nM	PMID[33515864]
NPT290	Individual protein	Serotonin 2a (5-HT2a) receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT295	Individual protein	Serotonin transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT291	Individual protein	Serotonin 2b (5-HT2b) receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	%Inhib (Mean)	=	3.2	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT101	Individual protein	Glucagon-like peptide 1 receptor	Homo sapiens	%Inhib (Mean)	=	3.22	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	Emax	=	7.2	%	PMID[36105346]
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	%Inhib (Mean)	=	-1.82	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT223	Individual protein	Alpha-2b adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	%max	=	94.4	%	PMID[36105346]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	EC50	=	1.995	nM	PMID[34676039]
NPT225	Individual protein	Beta-1 adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	Efficacy	=	113.8	%	PMID[34676039]
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	%Max (Mean)	=	2.4	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT101	Individual protein	Glucagon-like peptide 1 receptor	Homo sapiens	%Max (Mean)	=	-0.36	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT1109	Individual protein	Apelin receptor	Homo sapiens	%Max (Mean)	=	-1.079	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	Emax	=	10.9	%	PMID[34676039]
NPT224	Individual protein	Alpha-2c adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1163	Individual protein	Glutamate (NMDA) receptor subunit zeta 1	Rattus norvegicus	AC50	>	10000.0	nM	PMID[37468498]
NPT242	Individual protein	Dopamine D1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	AC50	=	4800.0	nM	PMID[37468498]
NPT2769	Individual protein	Thromboxane A2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT153	Individual protein	Androgen Receptor	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[36399795]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	4.0	nM	PMID[36399795]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[35483323]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1788	Individual protein	Alpha-1a adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT261	Individual protein	Monoamine oxidase A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT101	Individual protein	Glucagon-like peptide 1 receptor	Homo sapiens	%Inhib (Mean)	=	4.72	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	14.0	nM	PMID[36399795]
NPT1627	Individual protein	G-protein coupled receptor 35	Homo sapiens	%Max (Mean)	=	15.26	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT1627	Individual protein	G-protein coupled receptor 35	Homo sapiens	%Inhib (Mean)	=	-7.14	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT217	Individual protein	Adenosine A2a receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	IC50	=	1.259	nM	PMID[36105346]
NPT228	Individual protein	Norepinephrine transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT108	Individual protein	Estrogen receptor alpha	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	EC50	=	3.162	nM	PMID[36105346]
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	%Inhib (Mean)	=	-2.6	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	Emax	=	81.9	%	PMID[36105346]
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	%Max (Mean)	=	-2.59	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT292	Individual protein	Serotonin 2c (5-HT2c) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT232	Individual protein	Cannabinoid CB1 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	=	5.0	nM	PMID[36399795]
NPT244	Individual protein	Dopamine D3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	%Inhib (Mean)	=	1.33	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT101	Individual protein	Glucagon-like peptide 1 receptor	Homo sapiens	%Inhib (Mean)	=	-1.16	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT230	Individual protein	Bradykinin B2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT303	Individual protein	Vasopressin V1a receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT264	Individual protein	Muscarinic acetylcholine receptor M3	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT2719	Individual protein	Voltage-gated L-type calcium channel alpha-1C subunit	Rattus norvegicus	AC50	>	10000.0	nM	PMID[37468498]
NPT1454	Individual protein	Glucocorticoid receptor	Rattus norvegicus	IC50	=	6.31	nM	PMID[34676039]
NPT1647	Individual protein	Vasopressin V2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT101	Individual protein	Glucagon-like peptide 1 receptor	Homo sapiens	%Inhib (Mean)	=	15.29	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT218	Individual protein	Adenosine A3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1109	Individual protein	Apelin receptor	Homo sapiens	%Inhib (Mean)	=	27.19	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT1109	Individual protein	Apelin receptor	Homo sapiens	%Inhib (Mean)	=	33.17	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT262	Individual protein	Muscarinic acetylcholine receptor M1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	EC50	=	30.0	nM	PMID[35797110]
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Inhibition	=	34.2	%	PMID[22541068]
NPT72	Individual protein	Solute carrier organic anion transporter family member 1B3	Homo sapiens	Inhibition	=	103.89	%	PMID[23571415]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	=	137400.0	nM	PMID[21965623]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	>	135000.0	nM	PMID[20829430]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	=	101700.0	nM	PMID[22961681]
NPT862	Individual protein	Epoxide hydratase	Homo sapiens	Inhibition	=	59.4	%	PMID[28845983]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT27233	Single protein	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	Homo sapiens	Activity	=	172.36	%	PMID[28448136]
NPT27233	Single protein	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	Homo sapiens	FC	=	2.0	n.a.	PMID[28448136]
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	Activity	=	53.2	%	PMID[30419493]
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	Activity	=	13.6	%	PMID[30419493]
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	Activity	=	1.5	%	PMID[30419493]
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	Activity	=	62.6	%	PMID[30419493]
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	Activity	=	45.1	%	PMID[30419493]
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	Activity	=	58.1	%	PMID[30419493]
NPT30125	Single protein	C5a anaphylatoxin chemotactic receptor	Homo sapiens	%Inhib (Mean)	=	7.02	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	%Inhib (Mean)	=	-10.68	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT30125	Single protein	C5a anaphylatoxin chemotactic receptor	Homo sapiens	%Inhib (Mean)	=	-76.79	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	%Inhib (Mean)	=	-7.73	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT30125	Single protein	C5a anaphylatoxin chemotactic receptor	Homo sapiens	%Inhib (Mean)	=	2.31	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	%Inhib (Mean)	=	-4.06	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT30125	Single protein	C5a anaphylatoxin chemotactic receptor	Homo sapiens	%Inhib (Mean)	=	11.7	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	%Inhib (Mean)	=	-17.07	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT987	Individual protein	Histamine H3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT5301	Individual protein	Motilin receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT30125	Single protein	C5a anaphylatoxin chemotactic receptor	Homo sapiens	%Max (Mean)	=	-2.607	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT26694	Single protein	Lipoxin A4 receptor	Homo sapiens	%Max (Mean)	=	-3.73	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT542	Individual protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[17181172]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[17118655]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[17692519]
NPT5538	Individual protein	Fatty acid-binding protein, liver	Rattus norvegicus	Ki	=	22100.0	nM	PMID[18533710]
NPT5538	Individual protein	Fatty acid-binding protein, liver	Rattus norvegicus	Ki	=	41300.0	nM	PMID[18533710]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[20735001]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[20727743]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[21963986]
NPT73	Individual protein	Solute carrier organic anion transporter family member 1B1	Homo sapiens	Inhibition	=	10.7	%	PMID[22541068]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[24215891]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	Ki	=	561.0	nM	PMID[24446728]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	IC50	>	2000.0	nM	PMID[24656565]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	Ki	=	778.0	nM	PMID[24980053]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	IC50	=	440.0	nM	PMID[27810243]
NPT516	Individual protein	TNF-alpha	Homo sapiens	Inhibition	=	49.9	%	PMID[27847171]
NPT612	Individual protein	Canalicular multispecific organic anion transporter 1	Homo sapiens	IC50	>	133000.0	nM	PMID[23956101]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[28043796]
NPT29430	Single protein	Neuronal acetylcholine receptor protein alpha-4 subunit	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT23094	Single protein	C-X3-C chemokine receptor 1	Homo sapiens	%Inhib (Mean)	=	-7.197	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	%Inhib (Mean)	=	16.58	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT23094	Single protein	C-X3-C chemokine receptor 1	Homo sapiens	%Inhib (Mean)	=	-19.1	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	%Inhib (Mean)	=	1.75	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	-18.79	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT542	Individual protein	Progesterone receptor	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[35483323]
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	0.53	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	%Max (Mean)	=	-5.841	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT23094	Single protein	C-X3-C chemokine receptor 1	Homo sapiens	%Max (Mean)	=	0.4783	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4729	Individual protein	Cholecystokinin B receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	%Inhib (Mean)	=	1.067	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT23094	Single protein	C-X3-C chemokine receptor 1	Homo sapiens	%Inhib (Mean)	=	-14.31	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT542	Individual protein	Progesterone receptor	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[36399795]
NPT23094	Single protein	C-X3-C chemokine receptor 1	Homo sapiens	%Inhib (Mean)	=	-12.91	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT98	Individual protein	HERG	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	%Inhib (Mean)	=	3.84	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT542	Individual protein	Progesterone receptor	Homo sapiens	AC50	=	200.0	nM	PMID[37468498]
NPT4316	Individual protein	Phospholipase A2 group 1B	Rattus norvegicus	IC50	>	750000.0	nM	DOI[10.1016/S0960-894X(01)81260-9]
NPT752	Individual protein	Solute carrier organic anion transporter family member 1A1	Rattus norvegicus	Activity	=	26.0	%	PMID[8786566]
NPT622	Individual protein	Solute carrier organic anion transporter family member 2B1	Homo sapiens	Inhibition	=	-12.5	%	PMID[22541068]
NPT24057	Single protein	Transcription factor AP-1	Mus musculus	Ratio	=	2.33	n.a.	PMID[24831826]
NPT712	Individual protein	Bile salt export pump	Rattus norvegicus	IC50	=	231900.0	nM	PMID[21965623]
NPT28814	Single protein	Ghrelin receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT6197	Individual protein	Glucose-dependent insulinotropic receptor	Homo sapiens	%Inhib (Mean)	=	-26.71	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6035	Individual protein	Sphingosine 1-phosphate receptor Edg-1	Homo sapiens	%Inhib (Mean)	=	-13.6	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6035	Individual protein	Sphingosine 1-phosphate receptor Edg-1	Homo sapiens	%Inhib (Mean)	=	-18.09	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4003	Individual protein	G-protein coupled receptor 120	Homo sapiens	%Inhib (Mean)	=	-20.01	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6035	Individual protein	Sphingosine 1-phosphate receptor Edg-1	Homo sapiens	%Inhib (Mean)	=	-13.47	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6197	Individual protein	Glucose-dependent insulinotropic receptor	Homo sapiens	%Inhib (Mean)	=	4.873	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT29660	Single protein	Adhesion G-protein coupled receptor F1	Homo sapiens	%Inhib (Mean)	=	22.84	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT5104	Individual protein	Phosphodiesterase 3A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT92	Individual protein	Serotonin 1a (5-HT1a) receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT4003	Individual protein	G-protein coupled receptor 120	Homo sapiens	%Inhib (Mean)	=	-40.79	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT5975	Individual protein	Cyclooxygenase-1	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT4003	Individual protein	G-protein coupled receptor 120	Homo sapiens	%Inhib (Mean)	=	-32.71	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT29660	Single protein	Adhesion G-protein coupled receptor F1	Homo sapiens	%Inhib (Mean)	=	-18.7	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT29660	Single protein	Adhesion G-protein coupled receptor F1	Homo sapiens	%Max (Mean)	=	2.379	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6197	Individual protein	Glucose-dependent insulinotropic receptor	Homo sapiens	%Max (Mean)	=	3.118	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6035	Individual protein	Sphingosine 1-phosphate receptor Edg-1	Homo sapiens	%Inhib (Mean)	=	-12.55	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4003	Individual protein	G-protein coupled receptor 120	Homo sapiens	%Max (Mean)	=	-1.7	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT29660	Single protein	Adhesion G-protein coupled receptor F1	Homo sapiens	%Inhib (Mean)	=	-10.27	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4003	Individual protein	G-protein coupled receptor 120	Homo sapiens	%Inhib (Mean)	=	-20.1	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT29660	Single protein	Adhesion G-protein coupled receptor F1	Homo sapiens	%Inhib (Mean)	=	-6.03	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6035	Individual protein	Sphingosine 1-phosphate receptor Edg-1	Homo sapiens	%Max (Mean)	=	12.28	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6197	Individual protein	Glucose-dependent insulinotropic receptor	Homo sapiens	%Inhib (Mean)	=	-30.06	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT6197	Individual protein	Glucose-dependent insulinotropic receptor	Homo sapiens	%Inhib (Mean)	=	-1.83	%	GPCR results for EUbOPEN Chemogenomics Library 3
NPT4866	Protein family	Prostaglandin G/H synthase (cyclooxygenase)	Ovis aries	IC50	>	25000.0	nM	DOI[10.1016/S0960-894X(01)81260-9]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	4.0	nM/mg*min	PMID[12699389]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Inhibition	=	0.0	%	PMID[12699389]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	>	50000.0	nM	PMID[12699389]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[17181172]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	Ki	=	7.2	nM	PMID[17705362]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[17118655]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[17692519]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	Inhibition	=	30.0	%	PMID[20047280]
NPT74	Individual protein	Proto-oncogene c-JUN	Homo sapiens	Activity	=	2.33	%	PMID[19648015]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[20735001]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[20727743]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[21963986]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	0.0	%	PMID[12699389]
NPT4037	Individual protein	Multidrug and toxin extrusion protein 1	Homo sapiens	Inhibition	=	30.0	%	PMID[23241029]
NPT4037	Individual protein	Multidrug and toxin extrusion protein 1	Homo sapiens	IC50	>	500000.0	nM	PMID[23241029]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[24215891]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	Ki	=	0.36	nM	PMID[24446728]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	33.0	nM	PMID[24656565]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	IC50	=	40.0	nM	PMID[27810243]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	IC50	>	1000.0	nM	PMID[28043796]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[35483323]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Ratio	=	7.449	n.a.	PMID[33619967]
NPT543	Individual protein	Pregnane X receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT425	Individual protein	Serotonin 3a (5-HT3a) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT541	Individual protein	Mineralocorticoid receptor	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[36399795]
NPT30151	Single protein	Melanocortin receptor 3	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	420.0	nM	PMID[12361395]
NPT848	Cell line	N9	Homo sapiens	IC50	=	74.0	nM	PMID[12361395]
NPT1886	Cell line	J774	Mus musculus	IC50	=	169500.0	nM	PMID[12467611]
NPT2246	Cell line	T-cells	n.a.	IC50	=	5.0	nM	PMID[11229767]
NPT859	Cell line	HFF	Homo sapiens	IC50	=	0.51	nM	PMID[17181172]
NPT859	Cell line	HFF	Homo sapiens	EC50	=	1.9	nM	PMID[17181172]
NPT165	Cell line	HeLa	Homo sapiens	EC50	=	17.0	nM	PMID[17181172]
NPT2735	Cell line	RAW	Mus musculus	IC50	=	20.0	nM	PMID[17367124]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	3.4	ng/ml	PMID[17407277]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	0.21	ng/ml	PMID[17407277]
NPT389	Cell line	RPMI-8226	Homo sapiens	IC50	=	6.5	nM	PMID[17705362]
NPT859	Cell line	HFF	Homo sapiens	EC50	=	2.0	nM	PMID[17692519]
NPT859	Cell line	HFF	Homo sapiens	EC50	=	0.5	nM	PMID[17692519]
NPT1182	Cell line	J774.A1	Mus musculus	IC50	=	48.0	nM	PMID[17892941]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	49.9	%	PMID[11374953]
NPT848	Cell line	N9	Homo sapiens	Inhibition	=	82.0	%	PMID[11374953]
NPT1135	Cell line	Hepatocyte	Rattus norvegicus	Activity	=	96.0	IU/L	PMID[6677713]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	36.0	ug.mL-1	PMID[15165136]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	>	25.0	ug.mL-1	PMID[15165136]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	700.0	nM	PMID[11908984]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	50.0	nM	PMID[18625560]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	7.0	nM	PMID[18625560]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	>	100000.0	nM	PMID[18625560]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	72.0	%	PMID[18625560]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	94.0	%	PMID[18625560]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	0.0	%	PMID[18625560]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	0.0	%	PMID[19896853]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	90.0	%	PMID[19896853]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	69.0	%	PMID[19896853]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	84.0	%	PMID[20064725]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	73.0	%	PMID[20064725]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	89.0	%	PMID[20056549]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	73.0	%	PMID[20138527]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	84.0	%	PMID[20138527]
NPT1970	Cell line	THP-1	Homo sapiens	Activity	=	0.0	%	PMID[20138527]
NPT927	Cell line	PBMC	Homo sapiens	Inhibition	=	32.0	%	PMID[19835377]
NPT927	Cell line	PBMC	Homo sapiens	Inhibition	=	25.0	%	PMID[19835377]
NPT1970	Cell line	THP-1	Homo sapiens	Activity	=	73.0	%	PMID[20207143]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	69.0	%	PMID[20171758]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	90.0	%	PMID[20171758]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	69.0	%	PMID[20430485]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	90.0	%	PMID[20430485]
NPT1970	Cell line	THP-1	Homo sapiens	Activity	=	71.0	%	PMID[20638287]
NPT1970	Cell line	THP-1	Homo sapiens	Activity	=	85.0	%	PMID[20638287]
NPT306	Cell line	PC-3	Homo sapiens	FC	=	1.127	n.a.	PMID[16680159]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	860.0	nM	PMID[21288727]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	800.0	nM	PMID[21353543]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	10.0	nM	PMID[21353543]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	1.54	uM	PMID[21353543]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	27.01	ng/ml	PMID[21353543]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	20.0	nM	PMID[21361338]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	71.0	%	PMID[21737269]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	84.0	%	PMID[21737269]
NPT113	Cell line	RAW264.7	Mus musculus	FC	=	0.16	n.a.	PMID[21598928]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	72.0	%	PMID[22520258]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	86.0	%	PMID[22520258]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	470.0	nM	PMID[22372956]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	980.0	nM	PMID[22537362]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	71.0	%	PMID[22981334]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	84.0	%	PMID[22981334]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	84.0	%	PMID[23026000]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	76.0	%	PMID[23026000]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	94.0	%	DOI[10.1007/s00044-011-9856-1]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	72.0	%	DOI[10.1007/s00044-011-9856-1]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	94.0	%	DOI[10.1007/s00044-011-9834-7]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	72.0	%	DOI[10.1007/s00044-011-9834-7]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	84.0	%	DOI[10.1007/s00044-011-9943-3]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	71.0	%	DOI[10.1007/s00044-011-9943-3]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	86.0	%	DOI[10.1007/s00044-012-0144-5]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	72.0	%	DOI[10.1007/s00044-012-0144-5]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	80.0	%	DOI[10.1007/s00044-012-0109-8]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	71.0	%	DOI[10.1007/s00044-012-0109-8]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	355140.0	nM	DOI[10.1007/s00044-013-0504-9]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	5.5	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	1.0	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	3.5	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	3.6	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	>	200.0	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	2.4	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	1.2	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	0.92	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	7.6	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	130.0	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	88.0	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	82.0	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	9.4	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	6.1	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	0.47	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	4.1	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	2.1	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	1.9	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	66.0	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	72.0	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	55.0	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	14.0	nM	PMID[23199485]
NPT927	Cell line	PBMC	Homo sapiens	EC50	=	10.0	nM	PMID[23199485]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	1430.0	nM	PMID[23373965]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	98.24	%	PMID[23373965]
NPT927	Cell line	PBMC	Homo sapiens	Inhibition	=	43.0	%	PMID[23411072]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	70.4	%	PMID[23268606]
NPT927	Cell line	PBMC	Homo sapiens	Inhibition	=	80.0	%	PMID[23411072]
NPT927	Cell line	PBMC	Homo sapiens	IC50	=	9.5	nM	PMID[23411072]
NPT927	Cell line	PBMC	Homo sapiens	IC50	=	17.0	nM	PMID[23411072]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	72.0	%	DOI[10.1007/s00044-013-0825-8]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	85.0	%	DOI[10.1007/s00044-013-0825-8]
NPT1970	Cell line	THP-1	Homo sapiens	Activity	=	0.0	%	DOI[10.1007/s00044-013-0825-8]
NPT83	Cell line	MCF7	Homo sapiens	IC50	>	15000.0	nM	PMID[24992071]
NPT81	Cell line	A549	Homo sapiens	IC50	>	15000.0	nM	PMID[24992071]
NPT1161	Cell line	CHO	Cricetulus griseus	IC50	>	20000.0	nM	PMID[24992071]
NPT2615	Cell line	HEK-293T	Homo sapiens	IC50	>	20000.0	nM	PMID[24992071]
NPT169	Cell line	B16-F10	Mus musculus	Activity	=	1.3	%	PMID[24992071]
NPT169	Cell line	B16-F10	Mus musculus	Activity	=	3.7	%	PMID[24992071]
NPT169	Cell line	B16-F10	Mus musculus	Activity	=	0.8	%	PMID[24992071]
NPT169	Cell line	B16-F10	Mus musculus	Activity	=	94.1	%	PMID[24992071]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	9.5	%	PMID[24992071]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	5.9	%	PMID[24992071]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	2.4	%	PMID[24992071]
NPT83	Cell line	MCF7	Homo sapiens	Activity	=	82.8	%	PMID[24992071]
NPT1161	Cell line	CHO	Cricetulus griseus	Activity	=	4.2	%	PMID[24992071]
NPT1161	Cell line	CHO	Cricetulus griseus	Activity	=	0.0	%	PMID[24992071]
NPT1161	Cell line	CHO	Cricetulus griseus	Activity	=	95.8	%	PMID[24992071]
NPT2615	Cell line	HEK-293T	Homo sapiens	Activity	=	0.4	%	PMID[24992071]
NPT2615	Cell line	HEK-293T	Homo sapiens	Activity	=	0.1	%	PMID[24992071]
NPT2615	Cell line	HEK-293T	Homo sapiens	Activity	=	94.4	%	PMID[24992071]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	800.0	nM	PMID[25499882]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	0.016	ug.mL-1	PMID[25113933]
NPT1182	Cell line	J774.A1	Mus musculus	IC50	=	0.165	ug.mL-1	PMID[25113933]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	1.84	ug.mL-1	PMID[25113933]
NPT1182	Cell line	J774.A1	Mus musculus	IC50	=	9.09	ug.mL-1	PMID[25113933]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	0.016	%	PMID[24909081]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	1.84	%	PMID[24909081]
NPT927	Cell line	PBMC	Homo sapiens	IC50	=	8.0	nM	PMID[25338180]
NPT927	Cell line	PBMC	Homo sapiens	IC50	=	9.0	nM	PMID[25338180]
NPT927	Cell line	PBMC	Homo sapiens	IC50	=	2.0	nM	PMID[25338180]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	40.0	nM	PMID[25824662]
NPT1182	Cell line	J774.A1	Mus musculus	IC50	=	400.0	nM	PMID[25824662]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	4700.0	nM	PMID[25824662]
NPT1182	Cell line	J774.A1	Mus musculus	IC50	=	22000.0	nM	PMID[25824662]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	630.0	nM	PMID[26087384]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	800.0	nM	PMID[26305406]
NPT1886	Cell line	J774	Mus musculus	Inhibition	=	85.0	%	PMID[26915998]
NPT1886	Cell line	J774	Mus musculus	Inhibition	=	90.0	%	PMID[26915998]
NPT1886	Cell line	J774	Mus musculus	Inhibition	=	86.0	%	PMID[26915998]
NPT1886	Cell line	J774	Mus musculus	Inhibition	=	38.0	%	PMID[26915998]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	9.6	%	PMID[27217003]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	1.7	%	PMID[27217003]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	84.9	%	PMID[27797185]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	80.4	%	PMID[27797185]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	75.9	%	PMID[27797185]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	86.1	%	PMID[27797185]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	79.2	%	PMID[27797185]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	71.8	%	PMID[27797185]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	7000.0	nM	PMID[28499733]
NPT81	Cell line	A549	Homo sapiens	Activity	=	97.2	%	PMID[28489375]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	800.0	nM	PMID[29272126]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	60.9	%	PMID[29359942]
NPT521	Cell line	RBL-2H3	Rattus norvegicus	Inhibition	=	80.7	%	PMID[29381070]
NPT521	Cell line	RBL-2H3	Rattus norvegicus	Inhibition	=	79.7	%	PMID[29381070]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	8300.0	nM	PMID[29741372]
NPT34	Cell line	BV-2	Mus musculus	IC50	=	9500.0	nM	PMID[29482940]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	2500.0	nM	PMID[28598633]
NPT1886	Cell line	J774	Mus musculus	Inhibition	=	69.8	%	PMID[29523468]
NPT4137	Cell line	Splenocytes	Mus musculus	IC50	=	1.0	nM	PMID[29523468]
NPT1597	Cell line	J774.2	n.a.	Inhibition	=	62.0	%	PMID[29903412]
NPT1597	Cell line	J774.2	n.a.	Inhibition	=	40.0	%	PMID[29903412]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	10700.0	nM	PMID[29518326]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	40.0	%	PMID[29541375]
NPT1970	Cell line	THP-1	Homo sapiens	Inhibition	=	58.0	%	PMID[29541375]
NPT1970	Cell line	THP-1	Homo sapiens	Activity	=	0.0	%	PMID[29541375]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	2660.0	nM	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	100.2	%	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	2655.0	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	3219.4	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	3671.8	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	4056.3	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	3393.5	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	4063.6	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	4455.7	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	4810.1	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	6458.3	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	7533.7	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	8187.9	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	8748.1	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	269.5	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	332.8	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	393.4	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	422.7	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	791.0	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	927.7	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	1120.3	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	1240.5	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	924.1	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	1336.5	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	1594.9	pg/ml	PMID[30108912]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	1770.4	pg/ml	PMID[30108912]
NPT4137	Cell line	Splenocytes	Mus musculus	Inhibition	=	74.6	%	PMID[30293795]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	9400.0	nM	PMID[30579802]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	1200.0	nM	PMID[30579802]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	10.0	nM	PMID[30931559]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	34.25	%	PMID[31550154]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	18400.0	nM	PMID[31181925]
NPT519	Cell line	SH-SY5Y	Homo sapiens	Activity	=	16.0	%	PMID[30929949]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	5500.0	nM	PMID[31873014]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	5020.0	nM	PMID[31260892]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	159200.0	nM	PMID[31260892]
NPT113	Cell line	RAW264.7	Mus musculus	Ratio IC50	=	31.9	n.a.	PMID[31260892]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	8700.0	nM	PMID[30528697]
NPT113	Cell line	RAW264.7	Mus musculus	Ratio CC50/IC50	>	5.7	n.a.	PMID[30528697]
NPT1970	Cell line	THP-1	Homo sapiens	FC	=	1.3	n.a.	PMID[30419493]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	10.0	nM	PMID[31301930]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	130.0	nM	PMID[30808589]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	6000.0	nM	PMID[31577434]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	8400.0	nM	PMID[31577434]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	6100.0	nM	PMID[31577434]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	7900.0	nM	PMID[30817151]
NPT2246	Cell line	T-cells	n.a.	IC50	=	1600.0	nM	PMID[31961677]
NPT1970	Cell line	THP-1	Homo sapiens	IC50	=	2.512	nM	PMID[32631518]
NPT927	Cell line	PBMC	Homo sapiens	IC50	=	6.4	nM	PMID[32631518]
NPT927	Cell line	PBMC	Homo sapiens	IC50	=	4.3	nM	PMID[32631518]
NPT927	Cell line	PBMC	Homo sapiens	IC50	=	4.6	nM	PMID[32631518]
NPT927	Cell line	PBMC	Homo sapiens	IC50	=	3.8	nM	PMID[32631518]
NPT927	Cell line	PBMC	Homo sapiens	IC50	=	2.3	nM	PMID[32631518]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	32500.0	nM	PMID[32070636]
NPT1886	Cell line	J774	Mus musculus	IC50	=	5200.0	nM	PMID[32364737]
NPT1886	Cell line	J774	Mus musculus	Inhibition	=	87.1	%	PMID[32364737]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	4160.0	nM	PMID[32738985]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	24300.0	nM	PMID[32935986]
NPT2142	Cell line	REH	Homo sapiens	EC50	=	6.7	nM	PMID[34046609]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	580.0	nM	PMID[34333975]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[34333975]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[35707966]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	6700.0	nM	PMID[38117952]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	8280.0	nM	PMID[33667092]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	55.0	%	PMID[37336771]
NPT15	Cell line	Jurkat	Homo sapiens	Inhibition	=	98.87	%	PMID[37939268]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	6900.0	nM	PMID[33914536]
NPT113	Cell line	RAW264.7	Mus musculus	Imax	=	47.9	%	PMID[35998343]
NPT34	Cell line	BV-2	Mus musculus	IC50	=	2830.0	nM	PMID[37530709]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	22200.0	nM	PMID[35007071]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	50.0	%	PMID[37589086]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	n.a.	n.a.	n.a.	PMID[35998343]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	2600.0	nM	PMID[37369059]
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	65.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	76.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[37736179]
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	45535.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	41.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	78.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	101135.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	61.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	22878.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	93.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	62.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	20657.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	45.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Growth Rate	=	0.65	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	20.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	20.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	26.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Growth Rate	=	0.99	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	79.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	64.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	32.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	48.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	83.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	51.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	98.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	90.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	74.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	82.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	72.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	79.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	17.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	71.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	31.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	75.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	99.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	71.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Growth Rate	=	0.07	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT2615	Cell line	HEK-293T	Homo sapiens	Growth Rate	=	0.4	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	60.3	%	PMID[37043994]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[36399795]
NPT1970	Cell line	THP-1	Homo sapiens	FC	=	2.5	n.a.	PMID[34138563]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	7900.0	nM	PMID[37002536]
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	106.73	%	PMID[37852423]
NPT1970	Cell line	THP-1	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[34138563]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	620.0	nM	PMID[32795767]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	51.81	%	PMID[33515864]
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	60692.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	91.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	238.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	121.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	41.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	65.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	97.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	60.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	26450.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	98.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	65.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	499.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	IC50	>	50000.0	nM	PMID[33515864]
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	76.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[33933753]
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	80.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	77.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	49.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	50.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	68.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	17.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	94.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	33.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	378.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	288.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Growth Rate	=	0.95	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	26.88	%	PMID[37852423]
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	40.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	61.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	56.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	35035.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	59.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	63.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	84.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	43.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	45.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	8571.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	98.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Normal (%)	=	100.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	11828.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	75.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	75.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	73.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	n.a.	n.a.	%	PMID[35483323]
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	57.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	256.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	20807.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	70.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	5020.0	nM	PMID[35567964]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	>	50000.0	nM	PMID[37852423]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	8710.0	nM	PMID[33515864]
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	72.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	55.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[37337963]
NPT81	Cell line	A549	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[35483323]
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	81.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[35483323]
NPT113	Cell line	RAW264.7	Mus musculus	Inhibition	=	93.62	%	PMID[33933753]
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	26.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	68271.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	569.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	915.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	71.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	175.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1970	Cell line	THP-1	Homo sapiens	Imax	=	98.0	%	PMID[34138563]
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	11500.0	nM	PMID[37043994]
NPT1970	Cell line	THP-1	Homo sapiens	Imax	=	56.0	%	PMID[34138563]
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	453.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	72.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	14750.0	nM	PMID[33933753]
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	56.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	39.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	37.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	17.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Growth Rate	=	-1.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	620.0	nM	PMID[32485533]
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	68.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	83.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	50.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	35.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	59.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	31171.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	Activity	=	15.05	uM	PMID[37852423]
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	85.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	84.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	29842.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	46.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	28.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	74.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	44.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Total Cells	=	45150.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	80.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	14221.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	76.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Total Cells	=	44507.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	77.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	85.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	43.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	39.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	42.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Growth Rate	=	0.7	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	36.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	74.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	44.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	11.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	82.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	96.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	82.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	47000.0	nM	PMID[33454546]
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	63.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	8.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	374.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	77.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Fragmented Nuclei %	=	17.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Fragmented Nuclei %	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	32.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	685.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	63.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	420.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	760.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	28.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Pyknosed Nuclei (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	77.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	46.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	81.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	55.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Growth Rate	=	0.86	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT1970	Cell line	THP-1	Homo sapiens	Imax	=	86.0	%	PMID[34138563]
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	20.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	33.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	148.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	69.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	372.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Fragmented Nuclei (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	42.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	189.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	33.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	57.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	290.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Growth Rate	=	0.98	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	513.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	756.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	7900.0	nM	PMID[35063896]
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	391.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	242.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Control DMSO Mitotic Cells (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	294.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	86.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	159200.0	nM	PMID[35567964]
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	319.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Pyknosed Nuclei (%)	=	35.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	66.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	53.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Healthy Nuclei (%)	=	80.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	62.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	36.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	92.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	95.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Control DMSO Mitotic Cells (%)	=	66.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	436.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT113	Cell line	RAW264.7	Mus musculus	IC50	=	2000.0	nM	PMID[37856864]
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	79.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	92.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	219.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	58.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Normal (%)	=	97.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	32.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	186.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	29.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	263.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	31.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Healthy Nuclei (%)	=	69.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Fragmented Nuclei (%)	=	21.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	28.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	75.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	69.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	35.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	96.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Mitotic Cells (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Total Cell Count	=	264.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	497.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Total Cell Count	=	124.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Mitotic Cells (%)	=	56.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT2615	Cell line	HEK-293T	Homo sapiens	Population Apoptotic (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1045	Cell line	U2OS	Homo sapiens	Population Apoptotic (%)	=	100.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT1886	Cell line	J774	Mus musculus	CC50	=	91100.0	nM	PMID[29523468]
NPT113	Cell line	RAW264.7	Mus musculus	CC50	>	50000.0	nM	PMID[30528697]
NPT113	Cell line	RAW264.7	Mus musculus	CC50	=	4400.0	nM	PMID[35998343]
NPT433	Subcellular	Liver microsomes	Homo sapiens	Activity	=	445.0	pmol	PMID[22931300]
NPT27699	Cell line	B-cell line	Mus musculus	IC50	=	800.0	nM	PMID[31961677]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	20000.0	nM	DOI[10.6019/CHEMBL4651402]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	19952.62	nM	DOI[10.6019/CHEMBL4651402]
NPT28438	Unchecked	Unchecked	n.a.	Inhibition	=	98.27	%	PMID[37939268]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	920.0	nM	PMID[33744436]
NPT28438	Unchecked	Unchecked	n.a.	Activity	=	40.5	%	PMID[37146520]
NPT28438	Unchecked	Unchecked	n.a.	Activity	=	632.0	pg/ml	PMID[36379105]
NPT28438	Unchecked	Unchecked	n.a.	Inhibition	=	81.0	%	PMID[34355886]
NPT28438	Unchecked	Unchecked	n.a.	Inhibition	=	68.0	%	PMID[34355886]
NPT28438	Unchecked	Unchecked	n.a.	Activity	n.a.	n.a.	n.a.	PMID[36399795]
NPT28438	Unchecked	Unchecked	n.a.	Activity	=	52.82	%	PMID[37146520]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	3.6	nM	PMID[35870364]
NPT28438	Unchecked	Unchecked	n.a.	Activity	=	40.0	%	PMID[33360800]
NPT28438	Unchecked	Unchecked	n.a.	Activity	=	60.0	%	PMID[33360800]
NPT28438	Unchecked	Unchecked	n.a.	Activity	n.a.	n.a.	n.a.	PMID[35483323]
NPT28438	Unchecked	Unchecked	n.a.	Activity	=	1792.75	pg/ml	PMID[37146520]
NPT28438	Unchecked	Unchecked	n.a.	Activity	=	581.27	pg/ml	PMID[37146520]
NPT28438	Unchecked	Unchecked	n.a.	Inhibition	>	50.0	%	PMID[37314941]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	0.631	nM	PMID[20469868]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	0.5012	nM	PMID[20469868]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	0.3162	nM	PMID[20469868]
NPT312	Organism	Saccharomyces cerevisiae	Saccharomyces cerevisiae	IZ	=	9.0	mm	PMID[20739103]
NPT312	Organism	Saccharomyces cerevisiae	Saccharomyces cerevisiae	IZ	=	0.0	mm	PMID[20739103]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	74.7	%	PMID[21473609]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	83.0	%	PMID[21766854]
NPT1308	Tissue	Blood	Homo sapiens	EC50	=	6.9	nM	PMID[21899328]
NPT1308	Tissue	Blood	Homo sapiens	EC50	=	5.1	nM	PMID[21899328]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	2.3	nM	PMID[22506620]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	=	20.0	%	PMID[23758110]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	>	20000.0	nM	PMID[24992071]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	0.165	%	PMID[24909081]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	9.09	%	PMID[24909081]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	25.0	nM	PMID[26110443]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	48.0	%	PMID[27227459]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Inhibition	=	42.0	%	PMID[27227459]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	630.0	nM	PMID[27825545]
NPT21752	Cell line	Peritoneal macrophage cells	n.a.	IC50	=	150.0	nM	PMID[31358465]
NPT20	Organism	Candida albicans	Candida albicans	Inhibition	=	1.68	%	DOI[10.6019/CHEMBL4296181]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	Inhibition	=	-0.78	%	DOI[10.6019/CHEMBL4296181]
NPT2688	Organism	Sus scrofa	Sus scrofa	Inhibition	=	32.0	%	PMID[15125973]
NPT2688	Organism	Sus scrofa	Sus scrofa	Inhibition	=	35.0	%	PMID[15125973]
NPT2688	Organism	Sus scrofa	Sus scrofa	Inhibition	=	20.0	%	PMID[15125973]
NPT20763	Cell line	J774.1	Mus musculus	IC50	=	170000.0	nM	PMID[12608860]
NPT85	Organism	Filobasidiella neoformans	Cryptococcus neoformans	Inhibition	=	-1.2	%	DOI[10.6019/CHEMBL4296181]
NPT19	Organism	Escherichia coli	Escherichia coli	Inhibition	=	5.83	%	DOI[10.6019/CHEMBL4296181]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	Inhibition	=	2.35	%	DOI[10.6019/CHEMBL4296181]
NPT2922	Organism	Staphylococcus aureus subsp. aureus	Staphylococcus aureus subsp. aureus	Inhibition	=	-14.23	%	DOI[10.6019/CHEMBL4296181]
NPT29108	Cell line	Peritoneal macrophage	Mus musculus	Inhibition	=	17.0	%	PMID[34450495]
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	156.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	35.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	37.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	151.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	68.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	26.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	64.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	28.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	65.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	42.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	61.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	52.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	53.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	46.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	43.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	41.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	46.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	95.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	69.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	61.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	52.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	168.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	92.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	62.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	65.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	9.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	17835.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	20.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	93.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	50.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	16485.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	56.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	57.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	15057.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	37.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT21742	Cell line	L02	Homo sapiens	IC50	=	4620580.0	nM	PMID[33515864]
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	10.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	0.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Growth Rate	=	0.88	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	14985.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	66.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	69.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	94.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	17.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	184.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitochondria Different-Phenotype Cells (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	64.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	67.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	60.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	15078.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	73.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Growth Rate	=	0.73	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Incucyte)
NPT29108	Cell line	Peritoneal macrophage	Mus musculus	Inhibition	=	62.8	%	PMID[34450495]
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	23.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	31.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	45.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	16657.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	54.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	20.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	51.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	96.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	194.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	55.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Membrane Permeable-Phenotype Cells (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Hoechst High Intensity Objects (%)	=	6.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	1.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	53.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	44.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	175.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	68.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	26.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	29.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	30.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	3.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	26.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	62.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	12.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	19.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	48.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	16285.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	4.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	16.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Membrane Permeable-Phenotype (%)	=	2.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	167.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	55.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	38.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	36.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	58.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Total Cells	=	15171.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	7.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	53.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	68.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	21.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Healthy Nuclei (%)	=	62.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	21.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	42.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	25.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	21.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	173.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	149.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	40.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	50.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Mitotic Cells (%)	=	47.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Pyknosed Nuclei (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	34.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	35.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	39.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	140.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	166.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	14.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	48.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	50.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	15.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	22.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	172.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Pyknosed Nuclei (%)	=	18.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	38.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	180.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Fragmented Nuclei %	=	13.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	97.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Healthy Nuclei (%)	=	66.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitotic Cells (%)	=	52.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Control DMSO Tubulin Phenotype Different Cells (%)	=	24.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Mitochondria Different-Phenotype (%)	=	5.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Fragmented Nuclei (%)	=	26.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	150.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	27.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Total Cell Count	=	142.0	n.a.	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Normal (%)	=	98.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Apoptotic (%)	=	46.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT29444	Cell line	Fibroblast	Homo sapiens	Population Tubulin-Different-Phenotype (%)	=	34.0	%	Tm Shift (DSF) assay results for EUbOPEN Chemogenomis Library 2 (Multiplex)
NPT27	Others	Unspecified	n.a.	IC50	=	10.0	nM	PMID[11229767]
NPT27	Others	Unspecified	n.a.	IC50	=	40.0	nM	PMID[11229767]
NPT2	Others	Unspecified	n.a.	IC50	=	7.943	nM	PMID[15999989]
NPT27	Others	Unspecified	n.a.	Activity	=	3.2	%	PMID[16789751]
NPT27	Others	Unspecified	n.a.	Activity	<	1.0	%	PMID[16789751]
NPT2	Others	Unspecified	n.a.	Ratio	>	0.69	n.a.	PMID[15165136]
NPT2	Others	Unspecified	n.a.	IC50	=	5.0	nM	PMID[19323483]
NPT2	Others	Unspecified	n.a.	Activity	>	80.0	%	PMID[19323483]
NPT2	Others	Unspecified	n.a.	Activity	=	0.13	%	PMID[19648015]
NPT27	Others	Unspecified	n.a.	Activity	=	0.0	%	PMID[20064725]
NPT27	Others	Unspecified	n.a.	FC	=	0.4	n.a.	PMID[20469868]
NPT27	Others	Unspecified	n.a.	FC	=	7.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified	n.a.	FC	=	8.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified	n.a.	FC	=	40.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified	n.a.	FC	=	86.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified	n.a.	FC	=	300.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified	n.a.	FC	=	870.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified	n.a.	FC	=	2944.0	n.a.	PMID[20469868]
NPT27	Others	Unspecified	n.a.	Activity	=	0.0	%	PMID[20430485]
NPT27	Others	Unspecified	n.a.	Activity	=	0.0	%	PMID[20638287]
NPT2	Others	Unspecified	n.a.	Inhibition	=	61.6	%	PMID[21469695]
NPT27	Others	Unspecified	n.a.	Activity	=	0.0	%	DOI[10.1007/s00044-011-9856-1]
NPT27	Others	Unspecified	n.a.	Activity	=	0.0	%	DOI[10.1007/s00044-011-9834-7]
NPT27	Others	Unspecified	n.a.	IC50	>	15000.0	nM	PMID[24992071]
NPT2	Others	Unspecified	n.a.	IC50	=	610.0	nM	PMID[24938495]
NPT2	Others	Unspecified	n.a.	Activity	=	100.0	pg/ml	PMID[28799755]
NPT2	Others	Unspecified	n.a.	IC50	=	7.8	nM	PMID[30108696]
NPT26631	Cell line	Multiple myeloma cancer stem cell	n.a.	IC50	>	100000.0	nM	PMID[30108696]
NPT2	Others	Unspecified	n.a.	Activity	=	1.6	%	PMID[30419493]
NPT2	Others	Unspecified	n.a.	Inhibition	=	82.5	%	PMID[31473042]
NPT2	Others	Unspecified	n.a.	IC50	=	134.0	nM	PMID[31473042]
NPT747	Organism	Acinetobacter baumannii	Acinetobacter baumannii	Inhibition	=	8.59	%	DOI[10.6019/CHEMBL4296181]
NPT2	Others	Unspecified	n.a.	EC50	=	7.943	nM	PMID[32631518]
NPT27	Others	Unspecified	n.a.	Activity	=	92.74	%	PMID[30905542]
NPT2	Others	Unspecified	n.a.	Activity	=	65.0	%	PMID[33264011]
NPT20632	Organism	Chikungunya virus	Chikungunya virus	Activity	=	70.9	%	PMID[36940609]
NPT21769	Cell line	GES1	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[36399795]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT113	Cell line	RAW264.7	Mus musculus	Survival	=	91.0	%	PMID[26087384]
NPT113	Cell line	RAW264.7	Mus musculus	Survival	=	100.0	%	PMID[26087384]
NPT113	Cell line	RAW264.7	Mus musculus	Survival	=	97.7	%	PMID[29272126]
NPT113	Cell line	RAW264.7	Mus musculus	Survival	=	97.1	%	PMID[29272126]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	42.0	%	PMID[15125973]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	35.0	%	PMID[15125973]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	41.0	%	PMID[15125973]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	16.0	%	PMID[15125973]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	4.7	nM	PMID[10052971]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	3.5	nM	PMID[10052971]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	35800.0	nM	PMID[10579834]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	1000.0	nM	PMID[10579834]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	0.1	nM	PMID[11909709]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	0.1	nM	PMID[10617085]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.3	cm	PMID[3494125]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	0.3	nM	PMID[9873608]
NPT32	Organism	Mus musculus	Mus musculus	ED50	>	100.0	ug ear-1	DOI[10.1016/S0960-894X(01)81022-2]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.5	ug ear-1	DOI[10.1016/S0960-894X(01)81022-2]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.7	ug ear-1	DOI[10.1016/S0960-894X(01)81022-2]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	0.1	nM	PMID[11063620]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	82.0	%	PMID[15454241]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	96.0	%	PMID[15454241]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.27	ug	PMID[16821781]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	71.0	%	PMID[16697190]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	54.0	%	PMID[16697190]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	42.0	%	PMID[17608466]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	44.0	%	PMID[17608466]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	14.0	%	PMID[17608466]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	62.0	%	PMID[17608466]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	36.0	%	PMID[17608466]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	-86.0	%	PMID[17095218]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	72.0	%	PMID[19303290]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	81.0	%	PMID[9392883]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	76.0	%	PMID[9392883]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	89.0	%	PMID[9392883]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	93.0	%	PMID[9392883]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	84.0	%	PMID[9392883]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	82.0	%	PMID[7760072]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	92.0	%	PMID[10217718]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.75	%	PMID[19362486]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	20.0	%	PMID[19362486]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	81.0	%	PMID[19362486]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	35.0	%	PMID[19362486]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	22.0	million	PMID[19394230]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	18.5	million	PMID[19394230]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1404.0	million	PMID[19394230]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.003	mg.kg-1	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	90.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	24.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	31.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	33.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	69.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	75.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	84.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	87.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	88.0	%	PMID[19425597]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.54	%	PMID[20099827]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.77	%	PMID[20099827]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	68.0	%	PMID[20188549]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	24.0	%	PMID[20469868]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	67.0	%	PMID[20469868]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	88.0	%	PMID[20469868]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	83.0	%	PMID[20469868]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	60.0	%	PMID[20666458]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	90.0	%	PMID[20086156]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	90.0	%	PMID[21916510]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	78.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	83.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	65.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	50.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	69.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	81.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	43.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	48.0	%	PMID[21469692]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	63.0	%	PMID[22339472]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	83.0	%	PMID[24900359]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	102.0	%	PMID[22682057]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	70.0	%	PMID[22924688]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	83.0	%	PMID[25479567]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	97.0	%	PMID[25479567]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	70.5	%	PMID[26110443]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	506.3	mg/cm3	DOI[10.1039/C5MD00215J]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	91.0	%	PMID[27825545]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	100.0	%	PMID[27825545]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	59.0	%	PMID[30106292]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	10.1	%	PMID[30106292]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	43.0	%	PMID[30106292]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	90.0	%	PMID[30193941]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	51.0	%	PMID[31272795]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	46.8	%	PMID[31299586]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	45.0	%	PMID[32150408]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	72.0	%	PMID[32150408]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	82.0	%	PMID[32150408]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	45.0	%	PMID[32676146]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	37.0	%	PMID[32676146]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.53	mm	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	2.32	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.63	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	2.17	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.86	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.99	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.39	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.5	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	2.96	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.85	pg	PMID[30905542]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	17.19	g	PMID[31881455]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	72.9	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	40.9	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	30.6	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	66.9	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	75.1	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	46.1	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	55.9	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	58.7	%	PMID[33360197]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[34283606]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	3.7	n.a.	PMID[36908007]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[34315041]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[37948340]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[33933753]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[36708679]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[37314941]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[36655121]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[37257256]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	33.5	%	PMID[34138563]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	59.0	%	US-20210017201-A1
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[34138563]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	46.9	%	PMID[33706515]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	100.0	%	PMID[34218083]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[36462751]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[35576655]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[36394994]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	72.1	%	PMID[33706515]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[36689364]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	2.4	10^6/ml	PMID[34138563]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	51.0	%	PMID[34138563]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	37.0	%	US-20210017201-A1
NPT938	Organism	Cavia porcellus	Cavia porcellus	Inhibition	=	45.0	%	PMID[25102418]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Inhibition	=	88.0	%	PMID[25102418]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Activity	=	1.14	mg/ml	PMID[25102418]
NPT605	Organism	Homo sapiens	Homo sapiens	Potency	=	1.0	n.a.	PMID[6827553]
NPT605	Organism	Homo sapiens	Homo sapiens	Activity	=	0.8	%	PMID[20022146]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	95.0	%	PMID[9685237]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED30	<	2.5	uM kg-1	DOI[10.1016/S0960-894X(01)81260-9]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	99.0	%	PMID[15109623]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Potency	=	200.0	n.a.	PMID[6827553]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	69.0	%	PMID[6094808]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	IC50	=	20.0	nM	PMID[12039573]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.12	mg.kg-1	PMID[12039573]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	95.0	%	PMID[8709136]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	IC50	=	20.0	nM	PMID[12113803]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	95.0	%	PMID[1995900]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	98.0	%	PMID[1995900]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	71.0	%	PMID[3681891]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	80.0	%	PMID[3681891]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	89.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	96.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	92.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	70.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	85.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	94.0	%	PMID[17467123]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	FC	=	2.13	n.a.	PMID[22497764]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	40.0	%	DOI[10.1007/s00044-009-9190-z]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	30.0	%	DOI[10.1007/s00044-009-9190-z]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	23.0	%	DOI[10.1007/s00044-009-9190-z]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	89.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	87.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	71.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	45.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	33.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	29.0	%	DOI[10.1007/s00044-012-0406-2]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	17.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	25.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	30.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	53.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	76.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	16.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	28.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	34.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	49.0	%	PMID[71349]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	100.0	%	PMID[25690784]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	73.4	%	PMID[25824662]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	62.5	%	PMID[25824662]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	18.46	%	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	4.49	%	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	11.8	%	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	0.76	micrometer/day	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	6.58	10'9/L	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	25.77	%	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	53.03	%	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	213.0	U/L	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	63.64	U/L	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1.63	mmol/L	PMID[25874339]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1.6	%	PMID[28410442]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	6.7	ng/mg	PMID[28410442]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	2.2	pg/mg	PMID[28410442]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	86.0	%	PMID[28501511]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	0.03	U/L	PMID[28613871]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	65.0	%	PMID[28689977]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	59.2	g	PMID[29395981]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	91.0	%	PMID[30114661]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	79.1	%	PMID[27713015]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	n.a.	n.a.	n.a.	PMID[34491054]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	n.a.	n.a.	n.a.	PMID[35985062]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	97.6	%	PMID[36912866]

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference
Rattus norvegicus	Brain	Fu	=	0.238	n.a.	PMID[33619967]
Rattus norvegicus	Brain/Plasma	K(p,uu,brain)	=	0.081	n.a.	PMID[33619967]
Rattus norvegicus	Plasma	Fu	=	0.159	n.a.	PMID[33619967]

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC331613 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	19899
0.1-0.2	28799
0.2-0.3	1143
0.3-0.4	14
0.4-0.5	2
0.5-0.6	1
0.6-0.7	0
0.7-0.8	11
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Natural Product ID
0.5467	Remote Similarity	NPC481929

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC331613 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	7019
0.1-0.2	1938
0.2-0.3	104
0.3-0.4	33
0.4-0.5	18
0.5-0.6	18
0.6-0.7	2
0.7-0.8	11
0.8-0.85	2
0.85-0.9	0
0.9-0.95	0
0.95-1	4

Similarity Score	Similarity Level	Drug ID	Developmental Stage
1.0	High Similarity	NPD5216	Phase 2
1.0	High Similarity	NPD5217	Approved
1.0	High Similarity	NPD5225	Phase 4
1.0	High Similarity	NPD5226	Phase 4
0.8475	Intermediate Similarity	NPD5167	Pre-clinical
0.8475	Intermediate Similarity	NPD5169	Approved
0.7692	Intermediate Similarity	NPD6013	Phase 4
0.7463	Intermediate Similarity	NPD5247	Approved
0.7463	Intermediate Similarity	NPD5249	Phase 3
0.7353	Intermediate Similarity	NPD5250	Phase 4
0.7353	Intermediate Similarity	NPD5251	Phase 4
0.7246	Intermediate Similarity	NPD5248	Approved
0.7188	Intermediate Similarity	NPD4634	Phase 4
0.7077	Intermediate Similarity	NPD5141	Phase 2
0.7077	Intermediate Similarity	NPD5174	Approved
0.7077	Intermediate Similarity	NPD5175	Phase 2
0.7042	Intermediate Similarity	NPD8130	Phase 1
0.6615	Remote Similarity	NPD5222	Phase 4
0.6143	Remote Similarity	NPD6014	Approved
0.597	Remote Similarity	NPD5091	Approved
0.5942	Remote Similarity	NPD5127	Approved
0.5733	Remote Similarity	NPD6319	Phase 4
0.5733	Remote Similarity	NPD6883	Phase 4
0.5694	Remote Similarity	NPD6335	Phase 4
0.5556	Remote Similarity	NPD5128	Phase 2
0.5556	Remote Similarity	NPD5290	Phase 2
0.5526	Remote Similarity	NPD6015	Phase 4
0.5467	Remote Similarity	NPD7101	Phase 4
0.5467	Remote Similarity	NPD7102	Phase 4
0.5362	Remote Similarity	NPD5210	Phase 4
0.5352	Remote Similarity	NPD5215	Approved
0.5325	Remote Similarity	NPD6869	Phase 4
0.5256	Remote Similarity	NPD7290	Pre-clinical
0.5244	Remote Similarity	NPD7236	Phase 4
0.5132	Remote Similarity	NPD5134	Clinical (unspecified phase)
0.5132	Remote Similarity	NPD5135	Approved
0.507	Remote Similarity	NPD5223	Phase 4

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data