TCM Prescription: Hong Mao Yao Wine



Prescription Description
Prescription IDTCMF4497
Pinyin NameHong Mao Yao Jiu
Chinese Name鸿茅药酒
English NameHong Mao Yao Wine
Function Description痹病, 血劳
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病,未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH2175 Galla chinensis 五倍子 TCMH2175
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
TCMH794 Pittosporum tobira 海桐皮 TCMH794 SDP760001-18, GBVS1205-13
TCMH658 Nardostachys chinensis 甘松 TCMH658 GBVF2376-11
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH617 Poria 茯神 TCMH617
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH216 Fructus tsaoko 草果 TCMH216 GQ118666
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH672 Alpinia officinarum 高良姜 TCMH672 ITSAK2176-14
TCMH1835 Kaempferia galanga 山柰 TCMH1835 ITSAM898-14
TCMH1223 Tussilago farfara 款冬花 TCMH1223 ITSAH4326-14
TCMH2295 fructus foeniculi 小茴香 TCMH2295
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1163 Rhizoma anemones altaicae 九节菖蒲 TCMH1163
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH1275 Nelumbo nucifera 莲子 TCMH1275 ITSAI3109-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH2094 Arisaema consanguineum 天南星 TCMH2094 GBVY604-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH2217 NA 茜草 TCMH2217
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH512 Fructus amomi rotundus 豆蔻 TCMH512
TCMH860 Fructus galangae 红豆蔻 TCMH860
TCMH158 Piper longum 荜茇 TCMH158 ITSAJ4247-14
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH136 Os pardi 豹骨 TCMH136
TCMH1880 Moschus moschiferus 麝香 TCMH1880 GBMA2112-09
TCMH876 Semen oryzae cum monasco fermentatum 红曲 TCMH876
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT203 G6PD Glucose-6-phosphate 1-dehydrogenase Oxidoreductase P11413
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1297 Punta Toro virus
TCMT1310 Enterococcus hirae
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2C, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH 22.0651
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, GPER1, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PRKCB, PRKCD, PRKCE, PTGES, PTGS2, RORC, SRC, TEK, TRPV1, TYR 17.4496
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 16.9131
[BP] GO:0042221 response to chemical ABCB1, ABCG2, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR 16.3658
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TRPV1 15.2705
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPER1, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2C, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.6128
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPER1, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2C, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 13.5825
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 13.3004
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.0092
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, GPER1, HSD11B2, NR3C1, PRKCE, PRKCG, PTGES, PTGS2, RORC, SRC, TEK, TRPV1, TYR 11.9811
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DNMT1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, GPER1, HMGCR, HSPA1A, HTR1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 11.6733
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.6346
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 11.4613
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.4439
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 11.4439
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GPER1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.4439
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, GPER1, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 11.4439
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 11.2245
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 11.1612
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, GBA2, GLO1, HMGCR, HSD17B3, HSPA1A, HTR2C, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH 11.1612
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GPER1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 11.1396
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, DRD2, DRD3, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PRKCE, PTGS2 11.0343
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, CNR1, CNR2, DRD2, DRD3, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, KIT, PRKCE, PTGS2 11.0343
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, GPER1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2C, PRKCA, PRKCE, SLC22A1 10.5234
[BP] GO:0050896 response to stimulus ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD2, DRD3, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR 10.513
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, GRM5, HSD11B2, IGF1R, INSR, KIT, MMP2, NR3C1, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 10.4841
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 10.4658
[BP] GO:0042493 response to drug ABCB1, ABCG2, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD2, DRD3, EGFR, FABP3, HMGCR, HSD11B2, HTR2C, KDR, NR3C1, POLB, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TRPV1 10.4658
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 10.4435
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 10.4435
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 10.4394
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GPER1, GRIK5, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 10.3871
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.3871
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, INSR, MET, PIK3CA, PIK3CB, POLA1, POLB, PRKCB, PRKCE, SMAD3, SRC, TERT, TRPV1 10.3255
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 10.2215
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 10.1311
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 10.0468
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD11B2, INSR, KIT, NR3C1, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK, TRPV1 9.98991
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.96427
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD11B2, HSD17B2, NR3C1, PRKCE, PTGES, PTGS2, RORC, SRC, TYR 9.95922
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TERT, TRPV1 9.94829
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 9.63028
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, DRD2, DRD3, EGFR, GPER1, HCAR2, HMGCR, HTR2C, KDR, PIK3CB, PRKCE, PTGS2, SRC, TNKS, TNKS2, TRPV1 9.48009
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, GPER1, HMGCR, HTR1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK, TERT 9.47869
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.41735
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.32869
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.23068
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, PTGS1, PTGS2, TBXAS1 9.07912
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A 8.96955
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.9272
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, KIT, MMP9, PRKCD, PTGES, PTGS2, SRC, TERT 8.85096
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CNR1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 8.84493
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, GPER1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 8.79581
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.78483
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DRD3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.77526
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, APP, AR, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GPER1, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR2C, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR 8.76378
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 8.76378
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 8.75084
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, DRD2, DRD3, EGFR, FABP3, FLT3, GPER1, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 8.74047
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, EGFR, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.72108
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, EGFR, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.72108
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.69473
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.69473
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 8.62088
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HMGCR, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.60348
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, GPER1, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 8.49989
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, DRD2, DRD3, EGFR, GPER1, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2C, INSR, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TERT, TRPV1 8.47281
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.458
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 8.39794
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 8.38186
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ALOX12, APP, CDK6, CNR1, CNR2, CYP19A1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, GPER1, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.29193
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, GRM3, GRM8, HMGCR, HSPA1A, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.26705
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, GPER1, GRM1, GRM3, GRM5, GRM8, HTR1A 8.26452
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DRD2, DRD3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 8.2603
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.20735
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DRD2, EGFR, FLT3, GPER1, GRM1, HMGCR, HTR2C, INSR, KDR, KIT, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 8.17972
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 8.16173
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DNMT1, DRD2, DRD3, EGFR, FABP3, FLT3, GPER1, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 8.11594
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 8.06189
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, FABP3, FLT3, GPER1, HCAR2, HMGCR, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 8.06005
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD2, DRD3, GPER1, GRM1, GRM3, GRM5, GRM8, HTR1A 8.05252
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.97816
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPI, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 7.83506
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DRD2, DUSP3, EGFR, FLT3, GPER1, GRM1, HMGCR, HTR2C, IGF1R, INSR, KDR, KIT, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 7.83063
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 7.82724
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 7.80385
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.77785
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.7358
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DRD3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 7.70148
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 7.54892
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.54892
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DRD3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.54809
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, EGFR, GPER1, GRIK5, HTR1A, INSR, PTGS2, SLC1A1, SLC22A2, SLC22A3, SMAD3, TRPV1 7.48014
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 7.45249
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, HTR2C, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.33649
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, EGFR, ESR1, F3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.24314
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, EGFR, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.23406
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, EGFR, ESR1, F3, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.23183
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPER1, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, HTR2C, INSR, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH 7.16913
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.10879
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD2, DRD3, EGFR, GRM1, HMGCR, HSD11B2, HSPA1A, KIT, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, TYR 7.06035
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 7.00908
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 7.00214
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, AR, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPER1, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.99255
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 6.98615
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, PRKCG, SRC, TEK 6.94756
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, ALPI, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 6.88859
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.8775
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DRD2, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 6.84471
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.77122
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CHRM4, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 6.71544
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP2D6, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 6.71544
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPER1, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TRPV1, XDH 6.71544
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, GPER1, HCAR2, HMGCR, HSPA1A, KDR, KIT, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT, TRPV1 6.68336
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2, PRKCE 6.6662
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD2, DRD3, HMGCR, KDR, POLB, PRKCD, PRKCE, SRC 6.61692
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GRM1, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.60942
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GPER1, GRM1, GRM5, HMGCR, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.59397
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.50188
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR1, CNR2, CYP19A1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, GPER1, HMGCR, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 6.48486
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, DRD3, GBA2, HMGCR, HSD17B3, HTR1A, TYR 6.44498
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, ESR1, FLT3, HTR1A, KIT, MET, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TYR 6.44498
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 6.44158
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS 6.38136
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 6.35531
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 6.3408
[BP] GO:0050801 ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, EGFR, ESR1, FABP3, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 6.29179
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD2, DRD3, EGFR, GPER1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 6.27504
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 6.26209
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.25764
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 6.23358
[BP] GO:0019371 None CBR1, PTGES, PTGS1, PTGS2, TBXAS1 6.16229
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 6.16229
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, DNMT1, EGFR, ESR1, FLT3, GPER1, GRM5, IGF1R, INSR, KIT, MMP2, NR3C1, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 6.15353
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 6.11278
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.05791
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DYRK1A, EGFR, ESR1, KIT, PPARA, PRKCG, RORC, SRC, TOP2A 6.04678
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 5.90867
[BP] GO:0006855 None ABCB1, ABCG2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 5.89894
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 5.89894
[BP] GO:0098771 inorganic ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, DRD2, DRD3, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.8861
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, DRD2, DRD3, EGFR, GPER1, GPR35, GRM1, HCAR2, HTR2C, KIT, PRKCA, PTGS2, SLC1A1, SMAD3, TRPV1 5.84311
[BP] GO:0019725 cellular homeostasis ABCG2, APEX1, APP, BCL2, CA2, CA7, DRD2, DRD3, ESR1, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, PIK3CA, PIK3CB, POLA1, PRKCB, PRKCE, SMAD3, TRPV1 5.81423
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GPER1, GRM5, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 5.81423
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, KIT, PRKCD, SRC, TEK 5.80592
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PRKCG, SLC1A1 5.79078
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PRKCG, SLC1A1 5.79078
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, NR3C1, PTGS2, RORC, SRC, TRPV1 5.79
[BP] GO:0055082 cellular chemical homeostasis ABCG2, APP, BCL2, CA2, CA7, DRD2, DRD3, ESR1, GPER1, GPR35, GRIK5, GRM1, GRM5, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.78325
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, DNMT1, DRD2, DRD3, ESR1, GPER1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 5.77489
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 5.74508
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD2, DRD3, GPER1, HTR2C, KDR, PRKCE, SRC, TRPV1 5.74313
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, PPARA, RORC, SRC 5.71215
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AR, AURKB, BCL2, CNR1, CSNK2A1, CYP2D6, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 5.69096
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, KIT, PIK3CA, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.67264
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD2, DRD3, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.63151
[BP] GO:0007610 None APP, BCL2, CNR1, DRD2, DRD3, EGFR, GRM1, GRM5, HMGCR, HTR1A, HTR2C, INSR, KIT, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 5.61607
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPER1, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.57305
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPER1, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.54844
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, GPER1, KDR, KIT, PRKCA, PRKCB, PTGS2, TEK, TERT 5.54063
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, PIM1, PPARA, RORC, SRC 5.54063
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, GPER1, INSR, PRKCA, PRKCE, SRC, TERT 5.50461
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, KIT, MMP9, PTGES, PTGS2, TERT 5.4757
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AR, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, F3, FLT3, GPER1, GRM1, GRM5, HSPA1A, INSR, KIT, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.45303
[BP] GO:0050890 None ADORA1, APP, CHRM1, CNR1, DRD2, DRD3, EGFR, GRM5, HMGCR, INSR, KIT, PRKCG, PTGS2 5.40943
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, GPER1, HMGCR, HTR2C, KDR, PRKCA, PTPN1, SRC, TEK 5.37604
[BP] GO:0055080 cation homeostasis ABCG2, APP, BCL2, CA2, CA7, DRD2, DRD3, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.36655
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD2, DRD3, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.36655
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPI, ALPL, AOX1, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.35159
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 5.331
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, HTR2C, PRKCE, SRC, TNKS, TNKS2, TRPV1 5.32982
[BP] GO:0030003 cellular cation homeostasis ABCG2, APP, BCL2, CA2, CA7, DRD2, DRD3, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.32853
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, GPER1, HSD11B2, HSPA1A, HTR1A, HTR2C, KIT, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 5.31601
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.27104
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, NR3C1, PRKCD, PRKCE, PTGS2, SRC, TRPV1 5.24902
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD2, DRD3, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.20945
[BP] GO:0008217 None ADORA1, AR, CNR1, DRD2, DRD3, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 5.20436
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.20199
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.20199
[BP] GO:0006873 cellular ion homeostasis ABCG2, APP, BCL2, CA2, CA7, DRD2, DRD3, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.18797
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, DYRK1A, ESR1, GPER1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 5.18109
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, NQO2, PTGS1, RORC 5.15463
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD2, DRD3, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.15266
[BP] GO:0007154 None ADORA1, AR, AXL, BCL2, CHRM1, CHRM2, CHRM4, CNR1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PRKCG, PTGS2, SLC1A1, TEK, TRPV1 5.13705
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PRKCG, SLC1A1 5.10022
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PRKCG, SLC1A1 5.10022
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, GPER1, HMGCR, HTR2C, KDR, PRKCA, SRC, TEK 5.07405
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP2A 5.07178
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD2, DRD3, EGFR, GPER1, HCAR2, INSR, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TERT, TRPV1 5.00441
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, CNR1, DRD2, DRD3, EGFR, GPER1, HCAR2, HMGCR, HTR2C, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 4.99792
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD2, EGFR, GPER1, PRKCE, PTGS2 4.95536
[BP] GO:0065007 biological regulation ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.94235
[BP] GO:0009987 cellular process ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 4.9395
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2C, PPARA, PRKCB, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 4.93691
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CHRM1, CNR1, DRD2, DRD3, GPER1, GPR35, GRM5, HTR1A, MMP9, PRKCD, PRKCE, PTGS2 4.92009
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.91945
[BP] GO:0055065 metal ion homeostasis ABCG2, APP, BCL2, DRD2, DRD3, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.8925
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGES, PTGS1, PTGS2 4.86553
[BP] GO:0006875 cellular metal ion homeostasis ABCG2, APP, BCL2, DRD2, DRD3, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.84392
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.83864
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.82088
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, PPARA, RORC, SRC 4.79472
[BP] GO:0007267 None ADORA1, AR, CHRM1, CHRM2, CHRM4, CNR1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PRKCG, SLC1A1, TEK 4.75137
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, EGFR, GPER1, HCAR2, HMGCR, HTR1A, HTR2C, PRKCA, PRKCE 4.74888
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.71586
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.71559
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, GPER1, MMP12, PPARA, PRKCD, SMAD3, TEK 4.71348
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 4.7002
[BP] GO:0051172 None APEX1, APP, AR, AURKB, CSNK2A1, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 4.69713
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, GPER1, HCAR2, HSPA1A, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 4.66368
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, GPER1, HSD11B2, NR3C1, PTGS2, SRC 4.66319
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, ESR1, FABP4, GPER1, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 4.60348
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.54124
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.51015
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, DRD2, DRD3, GPER1, HMGCR, PPARA, PRKCD, SMAD3, TEK 4.49621
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, GPER1, GRM5, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 4.45975
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TERT, TNKS, TOP2A 4.45388
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CHRM1, CNR1, CNR2, CYP1B1, DRD2, DRD3, EGFR, GPER1, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HTR1A, INSR, KIT, PIK3CA, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 4.44775
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, DRD3, GPR35, MMP9, PRKCE, PTGS2 4.44382
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.44208
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KIT, PIK3CB, PRKCD, PTPN1, SRC 4.41587
[BP] GO:0042391 None ADORA1, APP, BCL2, CNR1, CNR2, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 4.40337
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2C, KIT, PRKCD, SRC, TEK 4.38995
[BP] GO:0007611 None APP, CNR1, DRD2, DRD3, EGFR, GRM5, HMGCR, INSR, KIT, PRKCG, PTGS2 4.38097
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 4.37874
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR, PRKCA, TERT 4.37694
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.31075
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.30621
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.30307
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GPER1, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.29018
[BP] GO:0015893 None ABCB1, ABCG2, CA2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.28393
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, GPER1, GRM1, GRM5, HSPA1A, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.25877
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT 4.2443
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GPER1, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.23863
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 4.23205
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, DRD3, GPER1, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 4.22348
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, GPER1, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TERT, TNKS, TOP2A 4.2065
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD, TNKS 4.17966
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 4.15751
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, ESRRB, F3, GPER1, HMGCR, HTR2C, INSR, KDR, KIT, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, TERT 4.15669
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.1422
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GPER1, HSD11B2, NR3C1, PTGS2, SRC 4.14086
[BP] GO:0003018 None ADORA1, CHRM1, EGFR, GPER1, HMGCR, HTR1A, PTGS2, SRC, TEK 4.14086
[BP] GO:0023052 None ADORA1, AR, CHRM1, CHRM2, CHRM4, CNR1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2C, PRKCG, SLC1A1, TEK 4.14086
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, GPER1, PPARA, PRKCD, SMAD3, TEK 4.12444
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, DNMT1, DRD2, DRD3, EGFR, ESR1, ESR2, GPER1, GRIK5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.11855
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK, TNKS 4.10969
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GPER1, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 4.10842
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, GPER1, GRM5, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 4.09977
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.09862
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 4.07887
[BP] GO:0010676 None ESRRB, GPER1, INSR, PPARA, PRKCE, SRC 4.06159
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA, PRKCD, PRKCE 4.06159
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGES, PTGS1, PTGS2 4.05565
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CHRM1, CNR1, CSNK2A1, DRD2, DRD3, EGFR, GPER1, HCAR2, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 4.03332
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, GPER1, KIT, PIK3CA, PIK3CB, POLB, PTGES, PTGS1, PTGS2, TRPV1 4.03014
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 4.02438
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, ESR1, GPER1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2C, INSR, PIK3CA, PIK3CB, SRC 4.02438
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, KIT, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.01945
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPER1, HMGCR, HTR2C, INSR, KDR, KIT, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH 3.97505
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, PRKCA, PRKCB, PRKCD, TNKS 3.9613
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 3.9458
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 3.93492
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 3.92506
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.90689
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, DRD2, ESR1, GRM5, HTR2C 3.89922
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, HMGCR 3.88569
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 3.88569
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, EGFR, GPER1, GRIK5, HCAR2, HMGCR, HTR1A, HTR2C, MMP12, PRKCA, PRKCE, SRC, TRPV1 3.8696
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 3.86781
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, GPER1, PPARA, PRKCD, PTGS2, SMAD3, TEK 3.86083
[BP] GO:0043278 None CNR1, DRD2, DRD3, PRKCE, PRKCG 3.86083
[BP] GO:0014072 None CNR1, DRD2, DRD3, PRKCE, PRKCG 3.86083
[BP] GO:0002791 None ACHE, ADORA1, CNR1, DRD2, DRD3, EGFR, GPER1, HCAR2, HMGCR, HTR2C, MMP12, PRKCA, PRKCE, SRC 3.86083
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, GPER1, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.85977
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.84597
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, GPER1, HMGCR, MMP2, MMP9, PTGS2, TERT 3.82186
[BP] GO:1901342 regulation of vasculature development ALOX12, CYP1B1, F3, GPER1, KDR, KIT, PRKCA, PRKCB, PTGS2, TEK, TERT, XDH 3.81953
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 3.81832
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 3.79694
[BP] GO:0070201 None ACHE, APP, BCL2, CHRM1, CNR1, DRD2, DRD3, EGFR, GPER1, HCAR2, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.78293
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HTR2C, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 3.78293
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD2, DRD3, EGFR, HSPA1A 3.78293
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.78293
[BP] GO:0045934 None APEX1, AR, AURKB, DNMT1, DRD2, DRD3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HSPA1A, MMP12, NR3C1, PPARA, PRKCA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1 3.76488
[BP] GO:0043434 None APEX1, FABP3, GPER1, HSD11B2, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 3.76488
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 3.76203
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 3.7593
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, DRD2, DRD3, EGFR, GPER1, GRM5, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 3.7521
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DNMT1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.74069
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, DRD2, F10, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 3.74051
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 3.71008
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, EGFR, GPER1, GRIK5, HCAR2, HMGCR, HTR1A, HTR2C, MMP12, PRKCA, PRKCE, SRC 3.70417
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.69714
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT, TNKS 3.68524
[BP] GO:0032870 cellular response to hormone stimulus APEX1, AR, EGFR, ESR1, FLT3, GPER1, INSR, KIT, NR3C1, PRKCD, PRKCE, SRC 3.68524
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK, TNKS 3.6834
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, KIT, PRKCD, PRKCE, PTPN1, SRC 3.66893
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HMGCR, POLB, PRKCD, PTGS2, TERT 3.66893
[BP] GO:0007612 None APP, DRD2, DRD3, GRM5, HMGCR, INSR, KIT, PTGS2 3.65553
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.61181
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, PRKCG, RORC, TOP2A 3.60168
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3, PRKCE 3.57773
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, GPER1, KIT, PTGS2 3.55624
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.53677
[BP] GO:0051223 None ACHE, APP, CHRM1, CNR1, DRD2, DRD3, EGFR, GPER1, HCAR2, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.53017
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.50563
[BP] GO:0032409 None ABCB1, APP, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9, PRKCD, PRKCE 3.50234
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.49218
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.49218
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.49218
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, PIK3CA, TNKS2 3.49105
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.48752
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 3.47436
[BP] GO:0045913 None ESRRB, GPER1, INSR, PPARA, PRKCE, SRC 3.45658
[BP] GO:0009410 None CNR1, CNR2, DRD2, DRD3, EGFR, NR3C1, PRKCE, PRKCG 3.44919
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.44249
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, GPER1, HSPA1A, INSR, PRKCE, TERT, TNKS 3.43331
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, HSD17B3 3.42377
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, DYRK1A, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, TERT, XDH 3.38112
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.37689
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.37689
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 3.37547
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA, PRKCA 3.35766
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.35195
[BP] GO:0050877 None ADORA1, APP, CHRM1, CNR1, CNR2, CYP1B1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, KIT, PRKCG, PTGS2, TRPV1, TYR 3.34232
[BP] GO:0045776 None ADORA1, CNR1, DRD2, DRD3, PPARA 3.33051
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA, PRKCA 3.32751
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, GRM1, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.32017
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HTR2C, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 3.32017
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.29697
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, CHRM1, DRD2, EGFR, GPER1, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.2885
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.27781
[BP] GO:0003013 None ADORA1, CHRM1, EGFR, GPER1, HMGCR, HTR1A, PTGS2, SRC, TEK 3.27147
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 3.27147
[BP] GO:0071383 None AR, EGFR, FLT3, GPER1, NR3C1, SRC 3.26761
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, GPER1, HCAR2, MMP12, PRKCE, SRC, TRPV1 3.26334
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.24149
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGES, PTGS2, SRC 3.22844
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GPER1, GRM5, IGF1R, INSR, PRKCD, SRC 3.22611
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, MET, PIK3CA, PPARA, PRKCG, SMAD3 3.22611
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.21698
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, EGFR, GPER1, IGF1R, INSR, PIK3CA, PRKCD, PRKCG, SRC, TNKS, TNKS2 3.20319
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM5, HMGCR, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.20319
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, KIT, PTGS2, SRC 3.19611
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.19288
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.17969
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.1566
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR, HSD17B3, TYR 3.1566
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, NR3C1, SRC 3.15127
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, DRD3, HTR1A, TYR 3.15127
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, KIT, SRC 3.13921
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD2, MET, PIK3CA, TRPV1 3.1299
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.11647
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGES, PTGS1, PTGS2 3.09472
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, PRKCE, TERT 3.09091
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.09007
[BP] GO:0008542 None APP, DRD2, DRD3, HMGCR, KIT 3.07877
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.07877
[BP] GO:0010675 None ESRRB, GPER1, INSR, PPARA, PRKCE, RORC, SRC 3.07136
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, PRKCE, SRC 3.07136
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 3.05209
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.0499
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5, PRKCD 3.04359
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.04197
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.04197
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, DRD2, FABP3, GPER1, HSPA1A, PTGES, PTGS2, SMAD3, TERT, XDH 3.01171
[BP] GO:0097746 None ADORA1, CHRM1, EGFR, GPER1, HMGCR, HTR1A, PTGS2 3.01171
[BP] GO:0035296 None ADORA1, CHRM1, EGFR, GPER1, HMGCR, HTR1A, PTGS2 3.01171
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.00416
[BP] GO:0048169 None APP, DRD2, GRM5, KIT 2.98583
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, CHRM1, DRD2, EGFR, GPER1, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.98576
[BP] GO:2000026 regulation of multicellular organismal development ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, GPER1, HMGCR, INSR, KDR, KIT, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK, TERT, XDH 2.98576
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD2, ESR1, GPER1, GPR35, GRM1, GRM5, HTR2C, PRKCE, SMAD3, TRPV1 2.96679
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD2, DRD3, EGFR, HMGCR, KIT, PTGS2, TYR 2.96679
[BP] GO:0022898 None ABCB1, APP, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9, PRKCE 2.9551
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 2.93038
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 2.92744
[BP] GO:0060341 regulation of cellular localization APP, AR, BCL2, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, GPER1, GRIK5, HMGCR, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 2.91386
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, PRKCE, SRC 2.90283
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC, TERT 2.89584
[BP] GO:0007632 None APP, DRD2, DRD3, HMGCR, KIT 2.89584
[BP] GO:0071396 cellular response to lipid AR, AXL, CDK6, EGFR, ESR1, FLT3, GPER1, NR3C1, PRKCE, RORC, SRC 2.88057
[BP] GO:1900542 None DRD2, DRD3, ESRRB, GPER1, GRM3, GRM8, INSR, PPARA, PRKCA 2.87576
[BP] GO:0050708 None ACHE, CNR1, DRD2, DRD3, EGFR, GPER1, HCAR2, HMGCR, MMP12, PRKCA, PRKCE, SRC 2.87468
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, CNR1, DRD2, DRD3, GPR35, HMGCR, HSPA1A, MMP9, PRKCB, PRKCE, PTGS2 2.86568
[BP] GO:0050880 None ADORA1, CHRM1, EGFR, GPER1, HMGCR, HTR1A, PTGS2 2.85903
[BP] GO:0051588 None DRD2, DRD3, GPER1, GRIK5, HTR1A, HTR2C 2.84286
[BP] GO:0035150 None ADORA1, CHRM1, EGFR, GPER1, HMGCR, HTR1A, PTGS2 2.83973
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AR, AURKB, CSNK2A1, DNMT1, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.82823
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.81927
[BP] GO:0043279 None CNR1, DRD2, DRD3, PRKCE, PRKCG, TRPV1 2.81927
[BP] GO:0040008 regulation of growth ALOX12, APP, AR, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, SMAD3, TNKS2 2.81927
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 2.81163
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 2.81163
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KIT, PIK3CB, PRKCD, PTPN1, SRC 2.81163
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, INSR, KIT, MMP2, MMP9, PTGS2, SRC, TOP2A 2.80799
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, PTGS2, SRC, TRPV1, TYR 2.80799
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 2.79447
[BP] GO:0006140 None DRD2, DRD3, ESRRB, GPER1, GRM3, GRM8, INSR, PPARA, PRKCA 2.79145
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.77915
[BP] GO:0072347 None CNR1, DRD2, DRD3, PRKCE, PRKCG 2.76208
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 2.76208
[BP] GO:0043412 macromolecule modification ALPI, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NR3C1, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.75331
[BP] GO:0008150 biological_process ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.75129
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B3, PTGES, PTGS1, PTGS2 2.74897
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1, PTGS2 2.73427
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.73031
[BP] GO:0035408 None PRKCA, PRKCB 2.73031
[BP] GO:0009115 None AOX1, XDH 2.73031
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.73031
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.73031
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.73031
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.73031
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 2.71379
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.71379
[BP] GO:0045936 None DRD2, DRD3, DUSP3, FABP4, GPER1, GRM3, GRM8, HMGCR, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 2.71357
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.71357
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.71357
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 2.71032
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.71032
[BP] GO:0010563 None DRD2, DRD3, DUSP3, FABP4, GPER1, GRM3, GRM8, HMGCR, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 2.71032
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, HMGCR, PTGS2, TRPV1, TYR 2.69798
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, GPER1, KDR, KIT, TEK 2.69692
[BP] GO:0061041 regulation of wound healing ALOX12, F3, HMGCR, PRKCA, PRKCD, PRKCE, SMAD3 2.67643
[BP] GO:0030817 None DRD2, DRD3, GPER1, GRM3, GRM8, PRKCA 2.67348
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GPER1, HSPA1A, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT 2.65915
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 2.64536
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, GPER1, HCAR2, MMP12, PRKCE, SRC 2.63205
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, DRD3, EGFR, HMGCR, HSD11B2, KIT, MMP12, PRKCD, PTGES, PTGS2, SMAD3, SRC, TRPV1, TYR 2.62933
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.62817
[BP] GO:0007194 None DRD2, DRD3, GRM3, PRKCA 2.61409
[BP] GO:1903827 regulation of cellular protein localization APP, AR, BCL2, CHRM1, CSNK2A1, EGFR, GPER1, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 2.6105
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.6068
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.6068
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.6068
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 2.6068
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.6068
[BP] GO:0006464 cellular protein modification process ALPI, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.60126
[BP] GO:0036211 protein modification process ALPI, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.60126
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.5953
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.59072
[BP] GO:0051234 None ABCB1, ABCG2, ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, DRD2, DRD3, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2C, KIT, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TNKS, TRPV1, XDH 2.58757
[BP] GO:0090276 None CNR1, DRD2, EGFR, GPER1, HMGCR, HTR2C, PRKCA, PRKCE 2.57843
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.57461
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.57461
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, GPER1, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, POLB, PRKCD, PTGES, PTGS1, PTGS2, SRC, TRPV1 2.57461
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD2, PTGS2 2.56461
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3, HTR1A 2.56461
[BP] GO:0044267 cellular protein metabolic process ALPI, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.56461
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.53898
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, KIT, PIK3CB, PTPN1, SRC 2.53746
[BP] GO:0031280 None DRD2, DRD3, GRM3, PRKCA 2.52762
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, GPER1, MMP9, PTGS2, SMAD3, SRC, XDH 2.52726
[BP] GO:0050678 None AR, CDK6, EGFR, F3, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 2.51434
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.51424
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.51424
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.51424
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.51424
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, PRKCE, SMAD3, TEK 2.51317
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, GPER1, KDR, KIT, TEK 2.51052
[BP] GO:1903829 positive regulation of cellular protein localization APP, BCL2, CHRM1, EGFR, GPER1, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TERT 2.50218
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.48066
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 2.47424
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.4659
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, EGFR, KIT, MET, PIK3CA, PIK3CB 2.46096
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, PTGS2, SRC, TRPV1, TYR 2.46033
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3, PRKCE 2.45576
[BP] GO:0043086 negative regulation of catalytic activity APP, CNR1, CNR2, CSNK2A1, DRD2, DRD3, DUSP3, FABP4, GRM3, HMGCR, IGF1R, MMP9, PRKCA, PRKCD, PTGS2, PTPN1, SRC 2.45347
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, DRD2, DUSP3, GPER1, MMP12 2.45307
[BP] GO:0051350 None DRD2, DRD3, GRM3, PRKCA 2.4461
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.4461
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.42981
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.42644
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 2.41733
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.40224
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 2.40155
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 2.39794
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, PRKCA, PTGS2, SMAD3 2.37935
[BP] GO:0008306 None APP, DRD2, DRD3, HMGCR, KIT 2.37565
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.37517
[BP] GO:0051179 None ABCB1, ABCG2, ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, DRD2, DRD3, EGFR, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2C, KIT, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TERT, TNKS, TNKS2, TRPV1, XDH 2.37306
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PIK3CB, PRKCG, PTPN1, SRC 2.36772
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.36355
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.36355
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.35244
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.35143
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.34387
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.34387
[BP] GO:0032412 None ABCB1, APP, DRD2, DRD3, GPR35, GRM5, MMP9, PRKCE 2.33962
[BP] GO:0030814 None DRD2, DRD3, GPER1, GRM3, GRM8, PRKCA 2.33962
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.33962
[BP] GO:0097756 None ADORA1, HMGCR, HTR1A, PTGS2 2.33962
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation GPER1, MMP2, MMP9, TERT 2.33962
[BP] GO:0099566 None GRM1, GRM5 2.33962
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.33962
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.33962
[BP] GO:0046110 None AOX1, XDH 2.33962
[BP] GO:0060160 None DRD2, DRD3 2.33962
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.33962
[BP] GO:0033602 None CNR1, DRD2 2.33962
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD2, DRD3, EGFR, HMGCR, KIT, POLB, PTGS2, TYR 2.33938
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TEK, TYR 2.32923
[BP] GO:1903034 regulation of response to wounding ALOX12, F3, HMGCR, PRKCA, PRKCD, PRKCE, SMAD3 2.31451
[BP] GO:0032413 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.29314
[BP] GO:0050866 negative regulation of cell activation ALOX12, AXL, CNR1, CNR2, DUSP3, GPER1, PRKCD 2.28606
[BP] GO:0030802 None DRD2, DRD3, GPER1, GRM3, GRM8, PRKCA 2.286
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.2839
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.2839
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.2839
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.2839
[BP] GO:0070920 None EGFR, ESR1, TERT 2.2839
[BP] GO:0032225 None DRD2, DRD3, PTGS2 2.2839
[BP] GO:0090257 None ADORA1, CHRM1, CHRM2, GPER1, KIT, PRKCA, PTGS2, SMAD3 2.28184
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD2, EGFR, FUT7, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.27452
[BP] GO:0019538 protein metabolic process ACHE, ALPI, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.26521
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.2633
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, DRD3, GPER1, GRIK5, HSPA1A, INSR, KDR, MET, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.2484
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GPER1, INSR, PPARA, PRKCE, RORC, SRC 2.23496
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 2.23031
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DRD2, DUSP3, ESR1, HSPA1A, KIT, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.23031
[BP] GO:0050679 None AR, EGFR, F3, KDR, MMP12, PRKCA, TEK 2.22159
[BP] GO:0045765 regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 2.22133
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.21285
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.21285
[BP] GO:0034762 None ABCB1, APP, BCL2, CA2, DRD2, DRD3, GPER1, GPR35, GRM5, MMP9, PRKCE 2.21213
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, GPER1, PTGS2 2.20477
[BP] GO:0050714 None ACHE, DRD2, EGFR, GPER1, HCAR2, MMP12, PRKCE, SRC 2.20455
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.19696
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, GPER1, MMP9, PTGS2, SMAD3, SRC, XDH 2.19328
[BP] GO:0090066 None ADORA1, ALOX15, CHRM1, EGFR, GPER1, HMGCR, HTR1A, PRKCD, PRKCE, PTGS2 2.19161
[BP] GO:0046887 positive regulation of hormone secretion CYP19A1, DRD2, EGFR, GPER1, HCAR2, PRKCE 2.18899
[BP] GO:0006810 None ABCB1, ABCG2, ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, DRD2, DRD3, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2C, KIT, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TNKS, TRPV1, XDH 2.18312
[BP] GO:1903076 None AR, CSNK2A1, EGFR, GPER1, PRKCE 2.18312
[BP] GO:0007626 None APP, DRD2, DRD3, GRM1, GRM5, HTR2C, PRKCE 2.17033
[BP] GO:0050999 None CNR1, CNR2, EGFR, TERT 2.16293
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.14602
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.14602
[BP] GO:0090330 regulation of platelet aggregation ALOX12, PRKCA, PRKCD 2.14602
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.13848
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.13848
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.13247
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, HTR1A 2.13247
[BP] GO:0045761 None DRD2, DRD3, GRM3, PRKCA 2.13231
[BP] GO:0051209 None DRD2, HTR2C, PRKCE, TRPV1 2.13231
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.13231
[BP] GO:0051283 None DRD2, HTR2C, PRKCE, TRPV1 2.13231
[BP] GO:0045595 regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CDK6, CNR1, DRD2, DRD3, EGFR, ESRRA, ESRRB, GPER1, HTR2C, KDR, KIT, PPARA, PRKCA, PRKCB, PTGS2, RORC, SMAD3, TERT, TRPV1, XDH 2.12853
[BP] GO:1900371 None DRD2, DRD3, GPER1, GRM3, GRM8, PRKCA 2.12673
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, EGFR, KIT, MET, PIK3CA, PIK3CB 2.12131
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PRKCD, PTGS2 2.12131
[BP] GO:0032410 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.12131
[BP] GO:1904063 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.12131
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, TEK, TRPV1, TYR 2.1123
[BP] GO:0030808 None DRD2, DRD3, GPER1, GRM3, GRM8, PRKCA 2.1123
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.10076
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, PRKCE 2.10007
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.10007
[BP] GO:0048638 regulation of developmental growth APP, AR, BCL2, DRD2, DRD3, INSR, PIK3CA, PIM1, TNKS2 2.09767
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, ESRRB, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.09752
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.09752
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.09752
[BP] GO:1901374 None SLC22A1, SLC22A2 2.09752
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.09752
[BP] GO:0070213 None TNKS, TNKS2 2.09752
[BP] GO:0006145 None AOX1, XDH 2.09752
[BP] GO:0038171 None CNR1, CNR2 2.09752
[BP] GO:0015874 None SLC22A1, SLC22A2 2.09752
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.09752
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.08997
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration DRD2, ESR1, GPER1, GPR35, GRM1, HTR2C, PRKCE, TRPV1 2.08087
[BP] GO:0006633 None ALOX12, ALOX15, PTGES, PTGS1, PTGS2 2.06807
[BP] GO:0042058 None ADORA1, APP, EGFR, GPER1, MMP9 2.06807
[BP] GO:0045785 positive regulation of cell adhesion ALOX12, ALOX15, CDK6, KDR, PIK3CA, PRKCA, PRKCE, SMAD3, SRC, TEK 2.06087
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, KIT, PIM1, PRKCB 2.05316
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.03673
[BP] GO:0007623 circadian rhythm DRD2, DRD3, DYRK1A, EGFR, PPARA, RORC 2.02893
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, KIT, PRKCB, PRKCD, RORC, SMAD3 2.02866
[BP] GO:0060359 None CNR1, DRD2, DRD3, PRKCE, PRKCG 2.02866
[BP] GO:1904375 None AR, CSNK2A1, EGFR, GPER1, PRKCE 2.02866
[BP] GO:2000351 None GPER1, KDR, TEK, TERT 2.01914
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.01914
[CC] GO:0005886 plasma membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPI, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TERT, TRPV1 11.3354
[CC] GO:0016020 membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPI, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TYR 10.1071
[CC] GO:0098590 plasma membrane region ABCB1, ABCG2, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, DRD2, EGFR, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SRC, TEK, TRPV1 8.56046
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, F10, F3, FLT3, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2C, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 8.26452
[CC] GO:0044459 plasma membrane part ABCB1, ABCG2, ADORA1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SRC, TEK, TRPV1 8.11594
[CC] GO:0044425 membrane part ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALPI, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, PIK3CA, PIK3CB, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TEK, TRPV1, TYR 7.23021
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, FLT3, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2C, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 6.98085
[CC] GO:0097060 None CHRM1, CHRM2, CHRM4, CNR1, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, TRPV1 5.9911
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM4, CNR1, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, SLC22A2, SRC, TRPV1 5.37605
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, EGFR, F10, FLT3, GBA2, GPER1, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, PTPN1, TBXAS1 5.00752
[CC] GO:0042734 None CNR1, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.79826
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, EGFR, GBA2, GPER1, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, TBXAS1 4.76248
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GPER1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 4.18224
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GPER1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 4.18224
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, GPER1, GRIK5, HMGCR, HSD17B3, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 4.06159
[CC] GO:0043005 None ADORA1, APP, BACE1, CA2, CHRM1, CHRM2, CNR1, CNR2, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PRKCG, PTGS2, SRC 3.99561
[CC] GO:0043227 membrane-bounded organelle ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SHBG, SLC1A1, SLC22A2, SLC47A1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.49218
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, GPER1, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, PTGES, SRC, TNKS2, TYR 3.40519
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KDR, KIT, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.3543
[CC] GO:0044464 cell part ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.28412
[CC] GO:0031224 None ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ALPI, ALPL, APP, AXL, BACE1, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP3A4, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, PTGES, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TBXAS1, TEK, TRPV1, TYR 3.12236
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.09986
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, BACE1, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, DRD2, DRD3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PRKCG, PTGS2, SRC, TEK 3.09817
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, DRD2, GPER1, GRIK5, SLC22A2 3.09047
[CC] GO:0043226 organelle ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SHBG, SLC1A1, SLC22A2, SLC47A1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.07865
[CC] GO:0097458 None ADORA1, APP, BACE1, CA2, CHRM1, CHRM2, CNR1, CNR2, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PRKCG, PTGS1, PTGS2, SLC22A2, SRC, TRPV1 3.03585
[CC] GO:0120025 None ADORA1, AKR1B1, APP, BACE1, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PRKCG, PTGS2, SRC, TEK 3.01892
[CC] GO:0043235 receptor complex ABCG2, APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.59072
[CC] GO:0016021 None ABCB1, ABCG2, ADORA1, ADORA3, ALPI, ALPL, APP, AXL, BACE1, CA12, CA14, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP3A4, DRD2, DRD3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, PTGES, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TBXAS1, TEK, TRPV1, TYR 2.52726
[CC] GO:0045211 None CHRM1, CHRM2, CHRM4, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 2.4659
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.30408
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.27208
[CC] GO:0032589 None ADORA1, GPER1, INSR, TRPV1 2.26725
[CC] GO:0045121 membrane raft APP, BACE1, CNR1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.26072
[CC] GO:0098857 membrane microdomain APP, BACE1, CNR1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.23996
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CNR1, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM3, INSR, PTGS1, SRC, TRPV1 2.09752
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CNR1, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM3, INSR, PTGS1, SRC, TRPV1 2.09752
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, SLC22A1, TEK 2.09752
[CC] GO:0031233 None CA4, F10, F3 2.03673
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, ALPI, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH 22.2595
[MF] GO:0043167 ion binding ABCB1, ABCG2, ACHE, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 16.9131
[MF] GO:0003824 catalytic activity ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DUSP3, DYRK1A, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 15.1853
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.0239
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR2C, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 12.2978
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, NR3C1, PPARA, RORC, TEK, TRPV1 11.9811
[MF] GO:0008270 zinc ion binding ALPI, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS 11.6346
[MF] GO:0008144 drug binding ABCB1, ABCG2, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD2, DRD3, DYRK1A, EGFR, FLT3, HSPA1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 11.6346
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, NR3C1, PPARA, RORC, TEK, TRPV1 10.8044
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, NR3C1, PPARA, PRKCE, RORC, SMAD3, TEK, TRPV1 10.5661
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, NR3C1, PPARA, RORC, TEK, TRPV1 10.5661
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 10.5234
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 10.3615
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 10.2215
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD11B2, HSD17B1, NR3C1, RORC, SHBG 9.71249
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.99908
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, XDH 8.91582
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 8.84019
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2C 8.62088
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, EGFR, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, TEK, TRPV1 8.11594
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, EGFR, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, TEK, TRPV1 8.11594
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 7.89902
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HMGCR, HSD11B2, HSD17B1, NQO2, POLA1, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH 7.80385
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 7.65801
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 7.55249
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, PPARA, RORC 7.45249
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, GPER1, HSD17B1, IGF1R, INSR, NQO2, NR3C1, SHBG 7.32785
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.26213
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 7.23912
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.16718
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.14678
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, TBXAS1, TYR 7.03232
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 6.9039
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 6.76052
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, RORC 6.76052
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.56855
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.477
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 6.4157
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TERT 6.38826
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 6.35284
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.16229
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.82051
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 5.6838
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, GPER1, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, SHBG, TRPV1 5.55764
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.29705
[MF] GO:0036094 small molecule binding ABCB1, ABCG2, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 5.2291
[MF] GO:0019899 enzyme binding ALPI, APP, AR, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, KIT, MET, NR3C1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 5.18109
[MF] GO:0000166 nucleotide binding ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 5.11823
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 5.11481
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.07368
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.01093
[MF] GO:0097159 organic cyclic compound binding ABCB1, ABCG2, ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SHBG, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, XDH 4.77959
[MF] GO:0015238 None ABCB1, ABCG2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.72592
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 4.71559
[MF] GO:0043168 anion binding ABCB1, ABCG2, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 4.57254
[MF] GO:0005524 ATP binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.46128
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.28206
[MF] GO:0030554 adenyl nucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.23205
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.18862
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.09862
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.05565
[MF] GO:0003674 molecular_function ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DRD2, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SHBG, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.86083
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, DRD2, HTR1A, HTR2C 3.85564
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 3.7593
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 3.7593
[MF] GO:0042802 identical protein binding ABCG2, ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, DYRK1A, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KDR, KIT, MET, MMP9, NQO2, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 3.73505
[MF] GO:1901363 heterocyclic compound binding ABCB1, ABCG2, ADORA1, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, XDH 3.63726
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR2C 3.52327
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.49218
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, DYRK1A, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.22251
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD2, DRD3, GPER1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2C 2.98215
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 2.9551
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 2.9551
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 2.9551
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.93038
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 2.92744
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 2.86723
[MF] GO:0032555 purine ribonucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.79208
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ABCG2, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.78138
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.73031
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.73031
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.73031
[MF] GO:0003845 None HSD11B1, HSD11B2 2.73031
[MF] GO:0008389 None CYP2A13, CYP2A6 2.73031
[MF] GO:0035403 None PRKCA, PRKCB 2.73031
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.71357
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.6068
[MF] GO:0017076 purine nucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.59072
[MF] GO:0032553 ribonucleotide binding ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.58757
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.51052
[MF] GO:0042803 protein homodimerization activity ABCG2, ACHE, AOX1, BCL2, DRD2, FLT3, HMGCR, KIT, NQO2, PTGS2, SLC22A1, SMAD3, TERT, TOP2A, TYR, XDH 2.48012
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.47327
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.42981
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 2.36551
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 2.35662
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, HTR1A, HTR2C 2.33962
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.33962
[MF] GO:0015307 None SLC47A1, SLC47A2 2.33962
[MF] GO:1901375 None SLC22A1, SLC22A2 2.33962
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.33962
[MF] GO:0004949 None CNR1, CNR2 2.33962
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.33962
[MF] GO:0005333 None SLC22A1, SLC22A2 2.33962
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.33962
[MF] GO:0005277 None SLC22A1, SLC22A2 2.33962
[MF] GO:0099583 None GRM1, GRM5 2.33962
[MF] GO:0008513 None SLC22A1, SLC22A2 2.33962
[MF] GO:0004699 None PRKCD, PRKCE 2.33962
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.3174
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, POLA1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.313
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, POLA1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.30701
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.21285
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.16293
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.14602
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.09752
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.09752
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.09752
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.09752
[MF] GO:0004971 None GRIA2, GRIA4 2.09752
[MF] GO:0005497 None AR, SHBG 2.09752
[MF] GO:0051425 None APP, INSR 2.09752
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.09752
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.05316
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.04801
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.03673
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.02866


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM1, GPR35, CHRM4, GRIK5, HTR1A, HTR2C, TRPV1, NR3C1, GRM1, GRM3, GRM5, CNR2, CNR1, ADORA3, GRM8, ADORA1, DRD2, DRD3, GRIA4 14.03
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 15.4777
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, GPER1, PRKCD, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 9.9147
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, CNR1, KIT, KDR, TEK, DRD2, MET 9.5672
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, PRKCB, CYP2D6, ALOX5, ALOX15, HTR1A, HTR2C, PRKCA, ALOX12, PTGS2, PTGS1 9.5672
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 9.7486
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, HTR2C, PRKCA, ALOX12, PIK3CB, TRPV1 9.032
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 8.9385
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.0753
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, AR, CDK6, PIK3CA, KIT, BCL2, MET 8.7469
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, DNMT1, ABCB1, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, MET 8.7469
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, PRKCG, GRIA2, GRM5, PRKCB, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 8.487
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 7.9574
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, ALOX15, HSD17B3, AKR1B1, ALOX12, HMGCR, PTGS2, CYP3A4, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, CBR1, TYR, POLA1, CYP2A6, AKR1B10, TBXAS1, CYP1A2, CYP1A1, ALPL, ALPI, PTGES 7.8204
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, CHRM1, PIK3CA, PRKCB, CHRM4, BCL2, PRKCA, PIK3CB 7.5082
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 7.8022
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.8425
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.2845
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 7.1105
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.4932
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, INSR, KIT, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 6.6755
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 6.828
Gap junction_Homo sapiens_hsa04540 PRKCG, GRM5, PRKCB, SRC, HTR2C, PRKCA, DRD2, GRM1, EGFR 7.2845
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, GRIA2, GRM5, PRKCB, CNR1, PRKCA, PTGS2, GRM1, GRIA4 6.828
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, PRKCA, PIK3CB, EGFR, IGF1R, CDK6, PIK3CA, KIT, KDR, BCL2, TEK, MET 6.5086
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, ALOX12, PTGS2, PTGES, PTGS1 7.2581
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 6.5885
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, KIT, GRM8, PRKCA, PIK3CB, GRM1, EGFR 6.6304
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, PIK3CA, ADORA1, HTR1A, PIK3CB, DRD2, PPARA, GRIA4 6.373
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.71
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 7.2845
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 6.3198
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 6.3197
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 6.373
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 5.5322
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, GRM5, CHRM1, PRKCB, HTR2C, PRKCA, GRM1, EGFR 4.9003
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.373
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 5.0951
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 4.9151
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 4.4375
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 4.3341
Long-term depression_Homo sapiens_hsa04730 PRKCG, GRIA2, PRKCB, PRKCA, GRM1, IGF1R 4.9151
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, GRIA2, PRKCB, PRKCA, DRD2, DRD3, GRIA4 4.0994
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.3341
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1 4.7025
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 4.6741
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.0304
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.5558
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 4.0422
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 4.0036
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 3.9311
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, SLC22A1, HMGCR, CYP3A4, ABCG2 4.5558
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 3.0807
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, SRC, CHRM4, PIK3CB, EGFR 2.8791
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PRKCE, ADORA1, PIK3CB 2.699
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 2.9674
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, KIT, PRKCA, TYR 2.8837
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.8837
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.9115
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 2.4959
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.1441
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.1511
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 2.5396
Alcoholism_Homo sapiens_hsa05034 DRD2 0.1563
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.5874
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.4998
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.1554
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.1918
Parkinson's disease_Homo sapiens_hsa05012 DRD2 0.2088
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.7095
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.222
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 2.5661
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, HMGCR, IGF1R 2.5166
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.8377
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 3.6598
Axon guidance_Homo sapiens_hsa04360 MET 0.2344
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 3.9311
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.6354
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.3821
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.3781
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.2874
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.3061
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.2969
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.3061
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3135
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.4495
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.4689
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.4456
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.4689
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.6844
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3282
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3294
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.3456
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP3A4 3.5812
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.1481
Peroxisome_Homo sapiens_hsa04146 XDH 0.3471
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.5957
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 1.9805
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.5558
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 1.756
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.3694
Oocyte meiosis_Homo sapiens_hsa04114 AR, IGF1R 0.6334
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 1.8677
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, PIK3CA, SRC, PIK3CB 1.7357
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.7131
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.3992
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.7233
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.3618
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.0581
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 4.2576
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4016
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, PIK3CA, TERT, PIK3CB 1.3982
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 1.5913
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 1.857
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.5699
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 1.9805
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.3585
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 2.5166
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.2206
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.6784
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.1411
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.1868
Shigellosis_Homo sapiens_hsa05131 SRC 0.4199
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4227
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.7357
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.1791
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.3806
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.819
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.1959
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.4999
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.2687
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.8318
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.16
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.4309
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 0.8681
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.3571
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.5859
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.4689
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 2.7378
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.4689
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.901
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 0.9562
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.4859
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.5079
Malaria_Homo sapiens_hsa05144 MET 0.498
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.5498
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 0.9739
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5028
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 1.7077
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5079
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 1.7721
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 1.7956
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.5214
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0372
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 1.7357
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.1554
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.7721
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1048
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5632
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6061
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.0622
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2115
DNA replication_Homo sapiens_hsa03030 POLA1 0.5979
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6476
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.6936
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.4184
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.2002
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2 2.1308
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6682
ABC transporters_Homo sapiens_hsa02010 ABCB1, ABCG2 1.3219
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.1868
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7029
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6578
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.385
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6936
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.4716
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5884
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.6631
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.4831
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.5242
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5459
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4636
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.761
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8336
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7724
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.1578
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2623
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9034


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)