| GO Term |
GO Name |
Enriched Genes |
Log10 Adjusted P-value |
|
[BP] GO:0065008 |
regulation of biological quality
|
ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APEX1, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
17.357 |
|
[BP] GO:1901700 |
response to oxygen-containing compound
|
AKR1B1, ALPL, APEX1, AR, AXL, BCL2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, GPER1, GRIK5, GRM5, HSD11B2, HSD17B2, HSP90AB1, IGF1R, INSR, MMP2, MMP9, PIK3CA, POLB, PPARA, PPARG, PTGS2, RORC, SLC6A4, SRC, TEK, TYR |
14.5585 |
|
[BP] GO:0042221 |
response to chemical
|
ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AR, AXL, BCL2, CA2, CA3, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PPARG, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR |
14.3776 |
|
[BP] GO:0010033 |
response to organic substance
|
ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AR, AXL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, POLB, PPARA, PPARG, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TYR |
14.3776 |
|
[BP] GO:0006629 |
lipid metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, TBXAS1 |
13.832 |
|
[BP] GO:0010647 |
positive regulation of cell communication
|
ADORA1, ADRA2A, AKR1B1, ALOX15, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, FLT3, GPER1, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
12.0026 |
|
[BP] GO:0023056 |
positive regulation of signaling
|
ADORA1, ADRA2A, AKR1B1, ALOX15, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, FLT3, GPER1, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
11.9776 |
|
[BP] GO:0015701 |
bicarbonate transport
|
CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
11.8717 |
|
[BP] GO:0044281 |
small molecule metabolic process
|
AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, FABP3, FUT7, GBA2, GLO1, HSPA1A, PIK3CA, PIM1, PPARA, PPARG, PTGS1, PTGS2, TBXAS1, TYR, XDH |
11.5027 |
|
[BP] GO:0006730 |
one-carbon metabolic process
|
CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
11.1416 |
|
[BP] GO:0019369 |
arachidonic acid metabolic process
|
ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 |
10.917 |
|
[BP] GO:0033559 |
unsaturated fatty acid metabolic process
|
ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 |
10.917 |
|
[BP] GO:0006690 |
icosanoid metabolic process
|
ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 |
10.5594 |
|
[BP] GO:0070887 |
cellular response to chemical stimulus
|
ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PPARG, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT |
10.5594 |
|
[BP] GO:0014070 |
response to organic cyclic compound
|
ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FLT3, GPER1, HSD11B2, HSP90AB1, PPARG, PTGS2, RORC, SLC6A4, SRC, TEK, TYR |
10.4519 |
|
[BP] GO:0008202 |
steroid metabolic process
|
AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
10.3209 |
|
[BP] GO:0042592 |
homeostatic process
|
ADORA1, ADRA2A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, KCNH2, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARG, SMAD3, SRC, TERT |
10.1975 |
|
[BP] GO:0044255 |
cellular lipid metabolic process
|
ACHE, AKR1B10, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, TBXAS1 |
10.1752 |
|
[BP] GO:0050896 |
response to stimulus
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AR, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR |
10.1752 |
|
[BP] GO:0006805 |
xenobiotic metabolic process
|
CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4, HSP90AB1, NQO2, PTGS1, RORC |
10.1752 |
|
[BP] GO:0010646 |
regulation of cell communication
|
ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
10.045 |
|
[BP] GO:0009719 |
response to endogenous stimulus
|
ADRA2A, AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, PPARG, PTGS2, SLC6A4, SMAD3, SRC, TEK |
10.045 |
|
[BP] GO:0008152 |
metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
10.0183 |
|
[BP] GO:0048522 |
positive regulation of cellular process
|
ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APEX1, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
9.95542 |
|
[BP] GO:0023051 |
regulation of signaling
|
ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
9.87758 |
|
[BP] GO:0019748 |
secondary metabolic process
|
AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR |
9.82319 |
|
[BP] GO:0009967 |
positive regulation of signal transduction
|
ADORA1, ADRA2A, AKR1B1, ALOX15, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPER1, GPR35, GRM1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
9.78929 |
|
[BP] GO:0009725 |
response to hormone
|
ADRA2A, AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD11B2, INSR, PPARA, PPARG, PTGS2, SLC6A4, SRC, TEK |
9.78929 |
|
[BP] GO:0043067 |
regulation of programmed cell death
|
ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GPER1, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH |
9.76231 |
|
[BP] GO:0042127 |
regulation of cell proliferation
|
ADORA1, ADORA3, ADRA2A, AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARG, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH |
9.62347 |
|
[BP] GO:0010941 |
regulation of cell death
|
ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GPER1, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH |
9.59407 |
|
[BP] GO:0071310 |
cellular response to organic substance
|
ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, HSP90AB1, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARG, PTGS2, RORC, SLC6A4, SMAD3, SRC |
9.4351 |
|
[BP] GO:0006631 |
fatty acid metabolic process
|
ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA, PPARG, PTGS1, PTGS2, TBXAS1 |
9.34249 |
|
[BP] GO:0042981 |
regulation of apoptotic process
|
ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GPER1, GRIK5, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH |
9.23902 |
|
[BP] GO:0051716 |
cellular response to stimulus
|
ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NUAK1, PIK3CA, POLA1, POLB, PPARG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A |
9.20479 |
|
[BP] GO:0044237 |
cellular metabolic process
|
ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
9.16562 |
|
[BP] GO:0033993 |
response to lipid
|
ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD11B2, HSD17B2, PPARG, PTGS2, RORC, SLC6A4, SRC, TYR |
9.10078 |
|
[BP] GO:0055114 |
oxidation-reduction process
|
AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PPARG, PTGS1, PTGS2, TBXAS1, TYR, XDH |
8.77727 |
|
[BP] GO:1901568 |
fatty acid derivative metabolic process
|
ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 |
8.77727 |
|
[BP] GO:2000145 |
regulation of cell motility
|
ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, PPARG, PTGS2, SMAD3, SRC, TEK, TERT |
8.77727 |
|
[BP] GO:0048518 |
positive regulation of biological process
|
ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, APEX1, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPER1, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
8.77517 |
|
[BP] GO:1902533 |
positive regulation of intracellular signal transduction
|
ADORA1, ADRA2A, AKR1B1, ALOX15, AR, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPER1, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH |
8.7676 |
|
[BP] GO:0032879 |
regulation of localization
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AR, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPER1, GPR35, GRIK5, GRM5, HCAR2, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT |
8.65371 |
|
[BP] GO:0030334 |
regulation of cell migration
|
ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, PPARG, PTGS2, SMAD3, SRC, TEK, TERT |
8.57261 |
|
[BP] GO:0001676 |
long-chain fatty acid metabolic process
|
ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TBXAS1 |
8.45116 |
|
[BP] GO:0001505 |
regulation of neurotransmitter levels
|
ACHE, CYP1B1, DRD1, DRD2, EGFR, GPER1, GRIK5, HSP90AA1, HSP90AB1, INSR, PTGS2, SLC1A1, SLC6A2, SLC6A4, SMAD3 |
8.29739 |
|
[BP] GO:0042493 |
response to drug
|
AKR1B1, APEX1, AXL, BCL2, CA3, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HSD11B2, HSP90AB1, KCNH2, KDR, POLB, PPARG, PTGS2, SLC6A2, SLC6A4, SRC |
8.18724 |
|
[BP] GO:0048584 |
positive regulation of response to stimulus
|
ADORA1, ADRA2A, AKR1B1, ALOX15, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPER1, GPR35, GRM1, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
8.18175 |
|
[BP] GO:0040012 |
regulation of locomotion
|
ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, PPARG, PTGS2, SMAD3, SRC, TEK, TERT |
8.11896 |
|
[BP] GO:0032787 |
None
|
ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PPARA, PPARG, PTGS1, PTGS2, TBXAS1 |
8.11629 |
|
[BP] GO:0051270 |
regulation of cellular component movement
|
ADORA1, ADORA3, ADRA2A, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, PPARG, PTGS2, SMAD3, SRC, TEK, TERT |
8.09938 |
|
[BP] GO:0051966 |
regulation of synaptic transmission, glutamatergic
|
ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 |
7.91427 |
|
[BP] GO:0019220 |
regulation of phosphate metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.74109 |
|
[BP] GO:0010562 |
positive regulation of phosphorus metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.68769 |
|
[BP] GO:0045937 |
positive regulation of phosphate metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.68769 |
|
[BP] GO:0051174 |
regulation of phosphorus metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.66282 |
|
[BP] GO:0070482 |
response to oxygen levels
|
ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, POLB, PPARA, PPARG, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT |
7.56517 |
|
[BP] GO:0071407 |
cellular response to organic cyclic compound
|
ALPL, APEX1, AR, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, GPER1, HSP90AB1, PPARG, PTGS2, RORC, SLC6A4, SRC |
7.42745 |
|
[BP] GO:0050804 |
modulation of chemical synaptic transmission
|
ACHE, ADORA1, CA2, CA7, DRD1, DRD2, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 |
7.38476 |
|
[BP] GO:0099177 |
regulation of trans-synaptic signaling
|
ACHE, ADORA1, CA2, CA7, DRD1, DRD2, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 |
7.38476 |
|
[BP] GO:0032844 |
regulation of homeostatic process
|
ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, EGFR, GPER1, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 |
7.33603 |
|
[BP] GO:0051896 |
regulation of protein kinase B signaling
|
AXL, DRD2, EGFR, F10, F3, GPER1, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH |
7.27509 |
|
[BP] GO:1902531 |
regulation of intracellular signal transduction
|
ADORA1, ADRA2A, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPER1, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH |
7.27509 |
|
[BP] GO:1901701 |
cellular response to oxygen-containing compound
|
AKR1B1, APEX1, AR, AXL, CDK6, CYP1B1, DRD1, EGFR, ESR1, GPER1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARG, PTGS2, RORC, SLC6A4, SRC |
7.27509 |
|
[BP] GO:0051173 |
positive regulation of nitrogen compound metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
7.26244 |
|
[BP] GO:0010604 |
positive regulation of macromolecule metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
7.23171 |
|
[BP] GO:0009628 |
response to abiotic stimulus
|
ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, EGFR, GRM1, HSD11B2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, POLB, PPARA, PPARG, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR |
7.14746 |
|
[BP] GO:0032501 |
multicellular organismal process
|
ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AR, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GPER1, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TNKS2, TYR |
7.12988 |
|
[BP] GO:0048513 |
animal organ development
|
ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, PIK3CA, POLB, PPARA, PPARG, SMAD3, SRC, TEK, TYR |
7.05095 |
|
[BP] GO:0050790 |
regulation of catalytic activity
|
ADORA1, ADORA3, ADRA2A, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
6.98614 |
|
[BP] GO:0030335 |
positive regulation of cell migration
|
ADRA2A, BCL2, DRD1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
6.95534 |
|
[BP] GO:0048878 |
chemical homeostasis
|
ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, PIK3CA, PIK3CB, PPARG, SMAD3 |
6.95534 |
|
[BP] GO:0043069 |
negative regulation of programmed cell death
|
ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
6.91523 |
|
[BP] GO:0060548 |
negative regulation of cell death
|
ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
6.89954 |
|
[BP] GO:0009893 |
positive regulation of metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
6.78626 |
|
[BP] GO:0031325 |
positive regulation of cellular metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, AURKB, BCL2, CDC25B, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
6.78324 |
|
[BP] GO:0008284 |
positive regulation of cell proliferation
|
ADRA2A, AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, GPER1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT |
6.78266 |
|
[BP] GO:2000147 |
positive regulation of cell motility
|
ADRA2A, BCL2, DRD1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
6.7504 |
|
[BP] GO:0010035 |
response to inorganic substance
|
AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SRC, TERT |
6.69703 |
|
[BP] GO:0009636 |
response to toxic substance
|
AKR1B1, ALPL, APEX1, AXL, BCL2, CA3, CES1, CYP1A1, CYP1B1, DRD1, DRD2, HSP90AA1, KDR, POLB, SLC6A4, SRC |
6.67799 |
|
[BP] GO:0032502 |
developmental process
|
ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, AR, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CES1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PPARG, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR |
6.6429 |
|
[BP] GO:0042327 |
positive regulation of phosphorylation
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD2, EGFR, ESRRB, FLT3, GPER1, GRM1, GRM5, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH |
6.60071 |
|
[BP] GO:0051272 |
positive regulation of cellular component movement
|
ADRA2A, BCL2, DRD1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
6.58932 |
|
[BP] GO:0019373 |
epoxygenase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 |
6.55289 |
|
[BP] GO:0006796 |
phosphate-containing compound metabolic process
|
ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, TEK, TNKS, XDH |
6.51435 |
|
[BP] GO:0010243 |
response to organonitrogen compound
|
AKR1B1, APEX1, DRD1, DRD2, EGFR, FABP3, FLT3, GPER1, GRM5, HSD11B2, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PTGS2, SLC6A4, SRC, TEK, TYR |
6.50308 |
|
[BP] GO:0015711 |
organic anion transport
|
CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, PPARG, SLC1A1 |
6.46398 |
|
[BP] GO:0040017 |
positive regulation of locomotion
|
ADRA2A, BCL2, DRD1, EGFR, F10, F3, GPER1, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
6.37916 |
|
[BP] GO:0043066 |
negative regulation of apoptotic process
|
ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
6.36034 |
|
[BP] GO:0001666 |
response to hypoxia
|
ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT |
6.30829 |
|
[BP] GO:0001934 |
positive regulation of protein phosphorylation
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, GPER1, GRM1, GRM5, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH |
6.28004 |
|
[BP] GO:0043401 |
steroid hormone mediated signaling pathway
|
AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, PPARG, RORC, SRC |
6.2102 |
|
[BP] GO:0042325 |
regulation of phosphorylation
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, GPER1, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH |
6.20459 |
|
[BP] GO:0044238 |
primary metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
6.18724 |
|
[BP] GO:0036293 |
response to decreased oxygen levels
|
ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT |
6.166 |
|
[BP] GO:0010817 |
regulation of hormone levels
|
ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, GPER1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
6.13285 |
|
[BP] GO:0030522 |
intracellular receptor signaling pathway
|
AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PIM1, PPARA, PPARG, RORC, SRC |
6.09527 |
|
[BP] GO:0007215 |
None
|
GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 |
6.07011 |
|
[BP] GO:0006793 |
phosphorus metabolic process
|
ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSP90AA1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, TEK, TNKS, XDH |
6.05335 |
|
[BP] GO:0065009 |
regulation of molecular function
|
ADORA1, ADORA3, ADRA2A, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPER1, GPR35, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
6.00239 |
|
[BP] GO:0044093 |
positive regulation of molecular function
|
ADORA1, ADRA2A, AR, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, F3, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
6.00239 |
|
[BP] GO:0032846 |
positive regulation of homeostatic process
|
AURKB, CA2, CA7, DRD1, DRD2, EGFR, GPER1, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 |
6.00239 |
|
[BP] GO:0048523 |
negative regulation of cellular process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
5.99991 |
|
[BP] GO:1901698 |
response to nitrogen compound
|
AKR1B1, APEX1, DRD1, DRD2, EGFR, FABP3, FLT3, GPER1, GRM5, HSD11B2, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PTGS2, SLC6A4, SRC, TEK, TYR |
5.98278 |
|
[BP] GO:0051049 |
regulation of transport
|
ACHE, ADORA1, ADRA2A, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, EGFR, GPER1, GPR35, GRIK5, GRM5, HCAR2, HSP90AB1, HSPA1A, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT |
5.96766 |
|
[BP] GO:0080134 |
regulation of response to stress
|
ADORA1, ADRA2A, CDK6, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH |
5.88949 |
|
[BP] GO:0042445 |
hormone metabolic process
|
ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
5.88372 |
|
[BP] GO:0010648 |
negative regulation of cell communication
|
ACHE, ADORA1, ADRA2A, AR, BCL2, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH |
5.80629 |
|
[BP] GO:0048583 |
regulation of response to stimulus
|
ADORA1, ADRA2A, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPER1, GPR35, GRM1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
5.80629 |
|
[BP] GO:0001932 |
regulation of protein phosphorylation
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GPER1, GRM1, GRM5, HSP90AB1, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH |
5.80629 |
|
[BP] GO:0023057 |
negative regulation of signaling
|
ACHE, ADORA1, ADRA2A, AR, BCL2, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH |
5.78383 |
|
[BP] GO:0007193 |
None
|
ADORA1, ADRA2A, CHRM2, DRD2, GRM1, GRM3, GRM5, GRM8 |
5.76898 |
|
[BP] GO:0048585 |
negative regulation of response to stimulus
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDK6, CYP19A1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH |
5.75993 |
|
[BP] GO:0019752 |
carboxylic acid metabolic process
|
ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TBXAS1, TYR |
5.68201 |
|
[BP] GO:0006950 |
response to stress
|
ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, GPER1, HSD11B2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A |
5.68201 |
|
[BP] GO:0016098 |
monoterpenoid metabolic process
|
CYP1A2, CYP2C19, CYP2D6, CYP3A4 |
5.68201 |
|
[BP] GO:0051897 |
positive regulation of protein kinase B signaling
|
AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK |
5.65182 |
|
[BP] GO:0051247 |
positive regulation of protein metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, GPER1, GRM1, GRM5, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.58614 |
|
[BP] GO:0051239 |
regulation of multicellular organismal process
|
ADORA1, ADORA3, ADRA2A, AR, AXL, BCL2, CA2, CDK6, CHRM2, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F3, GPER1, GPR35, GRM1, HCAR2, HSP90AB1, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARG, PTGS2, SLC1A1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH |
5.58226 |
|
[BP] GO:0009966 |
regulation of signal transduction
|
ADORA1, ADRA2A, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPER1, GPR35, GRM1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
5.57501 |
|
[BP] GO:0043085 |
positive regulation of catalytic activity
|
ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIK3CA, PIK3CB, PPARG, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
5.57501 |
|
[BP] GO:0007166 |
cell surface receptor signaling pathway
|
ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 |
5.56861 |
|
[BP] GO:0007188 |
None
|
ADORA1, ADRA2A, CHRM2, DRD1, DRD2, GPER1, GRM1, GRM3, GRM5, GRM8 |
5.55997 |
|
[BP] GO:0051050 |
positive regulation of transport
|
ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, EGFR, GPER1, HCAR2, HSP90AB1, INSR, KCNH2, MMP12, PPARG, PTGS2, SLC6A4, SMAD3, SRC, TERT |
5.54507 |
|
[BP] GO:0032270 |
positive regulation of cellular protein metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, GPER1, GRM1, GRM5, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.52191 |
|
[BP] GO:0007165 |
signal transduction
|
ADORA1, ADORA3, ADRA2A, AKR1B1, AR, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 |
5.51406 |
|
[BP] GO:0043410 |
positive regulation of MAPK cascade
|
ADORA1, ADRA2A, ALOX15, AR, DRD2, EGFR, FLT3, GPER1, GRM1, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH |
5.38428 |
|
[BP] GO:0009698 |
phenylpropanoid metabolic process
|
CYP1A1, CYP2A13, CYP2A6, CYP2D6 |
5.36396 |
|
[BP] GO:0009804 |
coumarin metabolic process
|
CYP1A1, CYP2A13, CYP2A6, CYP2D6 |
5.36396 |
|
[BP] GO:0009987 |
cellular process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
5.36396 |
|
[BP] GO:0031399 |
regulation of protein modification process
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH |
5.36163 |
|
[BP] GO:0048519 |
negative regulation of biological process
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APEX1, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, GRM3, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PPARG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
5.31116 |
|
[BP] GO:0009755 |
hormone-mediated signaling pathway
|
AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, PPARG, RORC, SRC |
5.31116 |
|
[BP] GO:0071704 |
organic substance metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
5.22492 |
|
[BP] GO:0048856 |
anatomical structure development
|
ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AR, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TEK, TYR |
5.19046 |
|
[BP] GO:0042446 |
hormone biosynthetic process
|
AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
5.18539 |
|
[BP] GO:0051338 |
regulation of transferase activity
|
ADORA1, ADRA2A, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, INSR, PIK3CA, PIK3CB, PPARG, PTPN1, SRC, TEK, TNKS |
5.18397 |
|
[BP] GO:0071495 |
cellular response to endogenous stimulus
|
ADRA2A, AKR1B1, APEX1, AR, DRD1, EGFR, ESR1, FLT3, GPER1, GRM5, IGF1R, INSR, MMP2, PPARG, PTGS2, SLC6A4, SMAD3, SRC |
5.15951 |
|
[BP] GO:0051347 |
positive regulation of transferase activity
|
ADORA1, ADRA2A, AURKB, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS |
5.14279 |
|
[BP] GO:0006468 |
protein phosphorylation
|
AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS |
5.1172 |
|
[BP] GO:0035690 |
cellular response to drug
|
AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, HSP90AB1, KCNH2, KDR, PTGS2, SRC |
5.06707 |
|
[BP] GO:0006820 |
anion transport
|
CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, PPARG, SLC1A1 |
5.04048 |
|
[BP] GO:0048511 |
rhythmic process
|
AXL, BCL2, CSNK2A1, DRD2, EGFR, ESR1, PPARA, PPARG, RORC, SLC6A4, SRC, TOP2A |
5.03825 |
|
[BP] GO:0043436 |
oxoacid metabolic process
|
ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TBXAS1, TYR |
5.03327 |
|
[BP] GO:0007187 |
None
|
ADORA1, ADRA2A, CHRM2, DRD1, DRD2, GPER1, GRM1, GRM3, GRM5, GRM8 |
4.96908 |
|
[BP] GO:0008610 |
lipid biosynthetic process
|
ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 |
4.96586 |
|
[BP] GO:1901652 |
response to peptide
|
AKR1B1, APEX1, FABP3, GPER1, GRM5, HSD11B2, IGF1R, INSR, PPARA, PPARG, PTGS2, SRC, TEK |
4.96586 |
|
[BP] GO:0006082 |
organic acid metabolic process
|
ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TBXAS1, TYR |
4.91733 |
|
[BP] GO:0018108 |
peptidyl-tyrosine phosphorylation
|
AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK |
4.91405 |
|
[BP] GO:1904407 |
positive regulation of nitric oxide metabolic process
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3 |
4.90316 |
|
[BP] GO:0045429 |
positive regulation of nitric oxide biosynthetic process
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3 |
4.90316 |
|
[BP] GO:0007196 |
None
|
GRM1, GRM3, GRM5, GRM8 |
4.87362 |
|
[BP] GO:0043408 |
regulation of MAPK cascade
|
ADORA1, ADRA2A, ALOX15, AR, DRD2, DUSP3, EGFR, FLT3, GPER1, GRM1, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH |
4.87362 |
|
[BP] GO:0018212 |
peptidyl-tyrosine modification
|
AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK |
4.85993 |
|
[BP] GO:0051726 |
regulation of cell cycle
|
APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, GPER1, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT, TNKS, TOP2A |
4.81103 |
|
[BP] GO:0019216 |
regulation of lipid metabolic process
|
ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, GPER1, HCAR2, PPARA, PPARG, PTGS2, RORC, SRC, TEK |
4.79269 |
|
[BP] GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway
|
AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK |
4.78963 |
|
[BP] GO:0006721 |
terpenoid metabolic process
|
AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR |
4.74206 |
|
[BP] GO:0046777 |
protein autophosphorylation
|
AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK |
4.73362 |
|
[BP] GO:0008217 |
None
|
ADORA1, AR, DRD2, HSD11B2, PPARA, PPARG, PTGS1, PTGS2, SMAD3 |
4.72918 |
|
[BP] GO:0034754 |
cellular hormone metabolic process
|
AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 |
4.71684 |
|
[BP] GO:0045787 |
positive regulation of cell cycle
|
APEX1, AURKB, CDC25B, CYP1A1, DRD2, DUSP3, EGFR, GPER1, HSP90AB1, INSR, SLC6A4, SRC, TERT |
4.70471 |
|
[BP] GO:0097267 |
omega-hydroxylase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1, CYP2C19 |
4.68765 |
|
[BP] GO:0003018 |
None
|
ADORA1, ADRA2A, DRD1, EGFR, GPER1, PTGS2, SLC6A4, SRC, TEK |
4.59507 |
|
[BP] GO:0031401 |
positive regulation of protein modification process
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, DRD2, EGFR, FLT3, GPER1, GRM1, GRM5, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH |
4.57125 |
|
[BP] GO:0017144 |
drug metabolic process
|
ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, HSPA1A |
4.50821 |
|
[BP] GO:0051972 |
regulation of telomerase activity
|
AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS |
4.47808 |
|
[BP] GO:0009892 |
negative regulation of metabolic process
|
ADORA1, ADRA2A, APEX1, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HCAR2, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH |
4.43833 |
|
[BP] GO:0071417 |
cellular response to organonitrogen compound
|
AKR1B1, APEX1, DRD1, EGFR, GPER1, GRM5, IGF1R, INSR, MMP2, PPARG, PTGS2, SLC6A4, SRC |
4.41604 |
|
[BP] GO:0050806 |
positive regulation of synaptic transmission
|
ADORA1, CA2, CA7, DRD1, DRD2, EGFR, GPER1, PTGS2 |
4.36155 |
|
[BP] GO:0042738 |
exogenous drug catabolic process
|
CYP1A2, CYP2A6, CYP2C19, CYP3A4 |
4.34256 |
|
[BP] GO:0031347 |
regulation of defense response
|
ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, GPER1, HSP90AB1, HSPA1A, MMP12, MMP2, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK |
4.33895 |
|
[BP] GO:1903428 |
positive regulation of reactive oxygen species biosynthetic process
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3 |
4.3344 |
|
[BP] GO:0016310 |
phosphorylation
|
AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS |
4.33435 |
|
[BP] GO:0048545 |
response to steroid hormone
|
ALPL, AR, BCL2, CA2, EGFR, FLT3, GPER1, HSD11B2, PTGS2, SRC |
4.32933 |
|
[BP] GO:0033674 |
positive regulation of kinase activity
|
ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK |
4.32652 |
|
[BP] GO:2000377 |
regulation of reactive oxygen species metabolic process
|
BCL2, CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, XDH |
4.30785 |
|
[BP] GO:0006720 |
isoprenoid metabolic process
|
AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR |
4.27032 |
|
[BP] GO:0031348 |
negative regulation of defense response
|
ADORA1, CYP19A1, DRD2, GPER1, MMP12, PPARA, PPARG, SMAD3, TEK |
4.26853 |
|
[BP] GO:0006979 |
response to oxidative stress
|
AKR1B1, APEX1, AXL, BCL2, CA3, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC |
4.26088 |
|
[BP] GO:0051098 |
regulation of binding
|
AURKB, BCL2, CYP2D6, HSP90AB1, MET, MMP9, PPARA, PPARG, SMAD3, SRC, TERT, TNKS |
4.26088 |
|
[BP] GO:0044092 |
negative regulation of molecular function
|
ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTGS2, PTPN1, SRC, TNKS |
4.26088 |
|
[BP] GO:0006694 |
steroid biosynthetic process
|
AKR1B1, CES1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.25301 |
|
[BP] GO:1901615 |
organic hydroxy compound metabolic process
|
AKR1B1, AKR1B10, ALOX15, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, GBA2, TYR |
4.21552 |
|
[BP] GO:0048660 |
regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, GPER1, MMP2, MMP9, PPARG, PTGS2, TERT |
4.20441 |
|
[BP] GO:0032847 |
regulation of cellular pH reduction
|
BCL2, CA2, CA7 |
4.19284 |
|
[BP] GO:0009891 |
positive regulation of biosynthetic process
|
AR, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A |
4.18804 |
|
[BP] GO:2000379 |
positive regulation of reactive oxygen species metabolic process
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, XDH |
4.14203 |
|
[BP] GO:0045428 |
regulation of nitric oxide biosynthetic process
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3 |
4.1226 |
|
[BP] GO:0009611 |
response to wounding
|
ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 |
4.12177 |
|
[BP] GO:0019222 |
regulation of metabolic process
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PPARG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
4.09407 |
|
[BP] GO:0045935 |
positive regulation of nucleobase-containing compound metabolic process
|
AR, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PPARG, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A |
4.08442 |
|
[BP] GO:0007216 |
None
|
GRM1, GRM3, GRM5, GRM8 |
4.08257 |
|
[BP] GO:0009056 |
catabolic process
|
ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSP90AA1, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH |
4.08257 |
|
[BP] GO:1901699 |
cellular response to nitrogen compound
|
AKR1B1, APEX1, DRD1, EGFR, GPER1, GRM5, IGF1R, INSR, MMP2, PPARG, PTGS2, SLC6A4, SRC |
4.07481 |
|
[BP] GO:0006811 |
None
|
CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A4 |
4.06882 |
|
[BP] GO:0007346 |
regulation of mitotic cell cycle
|
APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A |
4.06142 |
|
[BP] GO:0050801 |
ion homeostasis
|
BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, FABP3, GPER1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 |
3.97947 |
|
[BP] GO:0032268 |
regulation of cellular protein metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
3.9602 |
|
[BP] GO:0045860 |
positive regulation of protein kinase activity
|
ADORA1, ADRA2A, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, PIK3CA, PIK3CB, PTPN1, SRC |
3.95287 |
|
[BP] GO:0051240 |
positive regulation of multicellular organismal process
|
ADRA2A, AR, AXL, BCL2, CA2, CYP1B1, DRD2, EGFR, ESRRB, F3, GPER1, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PPARG, PTGS2, SLC1A1, SMAD3, SRC, TEK, TERT |
3.95153 |
|
[BP] GO:0007167 |
enzyme linked receptor protein signaling pathway
|
AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK |
3.9441 |
|
[BP] GO:0043549 |
regulation of kinase activity
|
ADORA1, ADRA2A, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK |
3.92674 |
|
[BP] GO:0043271 |
negative regulation of ion transport
|
ADORA1, ADRA2A, BCL2, DRD2, GPR35, KCNH2, MMP9, PTGS2 |
3.92355 |
|
[BP] GO:0044057 |
None
|
ADORA1, ADORA3, ADRA2A, CHRM2, DRD2, EGFR, GPER1, GPR35, GRM1, HCAR2, KCNH2, PTGS2, SLC1A1, SMAD3 |
3.91343 |
|
[BP] GO:0003006 |
developmental process involved in reproduction
|
ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSP90AB1, INSR, PPARG, PTGS2, SRC |
3.89221 |
|
[BP] GO:0050805 |
negative regulation of synaptic transmission
|
ACHE, ADORA1, DRD1, DRD2, PTGS2, SLC6A4 |
3.8603 |
|
[BP] GO:2000573 |
positive regulation of DNA biosynthetic process
|
AURKB, HSP90AA1, HSP90AB1, SRC, TNKS, TNKS2 |
3.8603 |
|
[BP] GO:0032225 |
None
|
DRD1, DRD2, PTGS2, SLC6A4 |
3.85816 |
|
[BP] GO:0031328 |
positive regulation of cellular biosynthetic process
|
AR, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, MMP12, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A |
3.84337 |
|
[BP] GO:0007154 |
None
|
ADORA1, AR, AXL, BCL2, CHRM2, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, PTGS2, SLC1A1, SLC6A2, TEK |
3.80076 |
|
[BP] GO:0022414 |
reproductive process
|
AKR1B1, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, HSP90AB1, INSR, MMP2, MMP9, PPARG, PTGS2, SLC6A4, SRC, TOP2A |
3.80076 |
|
[BP] GO:0001952 |
regulation of cell-matrix adhesion
|
BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK |
3.79497 |
|
[BP] GO:0010038 |
response to metal ion
|
ALOX15, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2, TERT |
3.78408 |
|
[BP] GO:0032101 |
regulation of response to external stimulus
|
ADORA1, CYP19A1, DRD1, DRD2, EGFR, ESR1, F3, FABP4, GPER1, KDR, MET, MMP12, PPARA, PPARG, PTGS2, SMAD3, TEK |
3.78087 |
|
[BP] GO:0051052 |
regulation of DNA metabolic process
|
AURKB, EGFR, GPER1, HSP90AA1, HSP90AB1, IGF1R, INSR, PIK3CA, PPARG, SRC, TNKS, TNKS2 |
3.76913 |
|
[BP] GO:2000278 |
regulation of DNA biosynthetic process
|
AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS, TNKS2 |
3.74663 |
|
[BP] GO:0045859 |
regulation of protein kinase activity
|
ADORA1, ADRA2A, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC |
3.74121 |
|
[BP] GO:0008285 |
negative regulation of cell proliferation
|
ADORA1, ADORA3, AR, BCL2, CDK6, CYP1B1, DRD2, FABP3, GPER1, HSPA1A, PPARG, PTGS2, SLC6A4, SMAD3, TERT, XDH |
3.74121 |
|
[BP] GO:0051130 |
positive regulation of cellular component organization
|
ALOX15, AR, AURKB, AXL, BCL2, DRD2, ESR1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, SMAD3, SRC, TEK, TNKS, TNKS2 |
3.70941 |
|
[BP] GO:0009895 |
negative regulation of catabolic process
|
ADORA1, ADRA2A, BCL2, EGFR, HCAR2, HSP90AB1, MET, PIK3CA, PPARA, SMAD3 |
3.69874 |
|
[BP] GO:1901564 |
organonitrogen compound metabolic process
|
ACHE, AKR1B1, ALPL, AOX1, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HSP90AA1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH |
3.69874 |
|
[BP] GO:0003013 |
None
|
ADORA1, ADRA2A, DRD1, EGFR, GPER1, PTGS2, SLC6A4, SRC, TEK |
3.69867 |
|
[BP] GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
CSNK2A1, F3, GPER1, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH |
3.68283 |
|
[BP] GO:0034614 |
cellular response to reactive oxygen species
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC |
3.67829 |
|
[BP] GO:0031960 |
response to corticosteroid
|
ALPL, BCL2, EGFR, FLT3, GPER1, HSD11B2, PTGS2, SRC |
3.65593 |
|
[BP] GO:2000021 |
regulation of ion homeostasis
|
ADORA1, BCL2, CA2, CA7, DRD1, DRD2, GPER1, KDR, SRC |
3.65291 |
|
[BP] GO:0042391 |
None
|
ADORA1, BCL2, DRD1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC |
3.65253 |
|
[BP] GO:0009968 |
negative regulation of signal transduction
|
ADRA2A, AR, BCL2, DRD2, DUSP3, EGFR, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH |
3.64779 |
|
[BP] GO:0010564 |
regulation of cell cycle process
|
APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, EGFR, GPER1, HSP90AA1, HSP90AB1, HSPA1A, INSR, TERT, TNKS |
3.63406 |
|
[BP] GO:0048608 |
reproductive structure development
|
AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC |
3.6118 |
|
[BP] GO:0048010 |
vascular endothelial growth factor receptor signaling pathway
|
AXL, HSP90AA1, KDR, PIK3CA, PIK3CB, SRC |
3.59899 |
|
[BP] GO:0051054 |
positive regulation of DNA metabolic process
|
AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC, TNKS, TNKS2 |
3.5782 |
|
[BP] GO:0098771 |
inorganic ion homeostasis
|
BCL2, CA12, CA2, CA7, DRD1, DRD2, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 |
3.57473 |
|
[BP] GO:0006367 |
transcription initiation from RNA polymerase II promoter
|
AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC |
3.56801 |
|
[BP] GO:0043405 |
regulation of MAP kinase activity
|
ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC |
3.55399 |
|
[BP] GO:0001503 |
ossification
|
ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK |
3.54055 |
|
[BP] GO:0009894 |
regulation of catabolic process
|
ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 |
3.5322 |
|
[BP] GO:0031324 |
negative regulation of cellular metabolic process
|
ADRA2A, APEX1, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DUSP3, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH |
3.52244 |
|
[BP] GO:0050728 |
negative regulation of inflammatory response
|
ADORA1, CYP19A1, GPER1, PPARA, PPARG, SMAD3, TEK |
3.51959 |
|
[BP] GO:0043434 |
None
|
APEX1, FABP3, GPER1, HSD11B2, INSR, PPARA, PPARG, PTGS2, SRC, TEK |
3.51517 |
|
[BP] GO:0002682 |
regulation of immune system process
|
ADORA1, ALOX15, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, GPER1, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PPARG, PTPN1, SMAD3, SRC |
3.51323 |
|
[BP] GO:0080090 |
regulation of primary metabolic process
|
ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
3.49278 |
|
[BP] GO:0008283 |
cell proliferation
|
ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, POLA1, SRC, TEK, TYR |
3.49176 |
|
[BP] GO:0048661 |
positive regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT |
3.48117 |
|
[BP] GO:0031323 |
regulation of cellular metabolic process
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
3.43901 |
|
[BP] GO:0010557 |
positive regulation of macromolecule biosynthetic process
|
AR, AURKB, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, PPARA, PPARG, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A |
3.41307 |
|
[BP] GO:0071396 |
cellular response to lipid
|
AR, AXL, CDK6, EGFR, ESR1, FLT3, GPER1, PPARG, RORC, SLC6A4, SRC |
3.38092 |
|
[BP] GO:0009820 |
alkaloid metabolic process
|
CYP1A2, CYP2D6, CYP3A4 |
3.36758 |
|
[BP] GO:0045834 |
positive regulation of lipid metabolic process
|
FABP3, FLT3, PPARA, PPARG, PTGS2, SRC, TEK |
3.3424 |
|
[BP] GO:0007268 |
None
|
CHRM2, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 |
3.3424 |
|
[BP] GO:0098916 |
None
|
CHRM2, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 |
3.3424 |
|
[BP] GO:0000302 |
response to reactive oxygen species
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC |
3.32633 |
|
[BP] GO:0038083 |
peptidyl-tyrosine autophosphorylation
|
EGFR, IGF1R, INSR, KDR, SRC |
3.32633 |
|
[BP] GO:0097746 |
None
|
ADORA1, ADRA2A, DRD1, EGFR, GPER1, PTGS2, SLC6A4 |
3.32633 |
|
[BP] GO:0035296 |
None
|
ADORA1, ADRA2A, DRD1, EGFR, GPER1, PTGS2, SLC6A4 |
3.32633 |
|
[BP] GO:0032355 |
response to estradiol
|
CYP1A2, EGFR, ESR1, ESRRA, GPER1, PTGS2, SLC6A4 |
3.32633 |
|
[BP] GO:0033273 |
response to vitamin
|
ALPL, CYP1A1, EGFR, PPARG, PTGS2, TYR |
3.30778 |
|
[BP] GO:1903426 |
None
|
EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3 |
3.30778 |
|
[BP] GO:1902532 |
negative regulation of intracellular signal transduction
|
BCL2, DRD2, DUSP3, ESR1, GPER1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH |
3.28651 |
|
[BP] GO:1900542 |
None
|
ADRA2A, DRD1, DRD2, ESRRB, GPER1, GRM3, GRM8, INSR, PPARA |
3.28651 |
|
[BP] GO:0099536 |
None
|
CHRM2, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 |
3.26709 |
|
[BP] GO:0099537 |
None
|
CHRM2, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 |
3.26709 |
|
[BP] GO:2000116 |
regulation of cysteine-type endopeptidase activity
|
CSNK2A1, F3, GPER1, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH |
3.26074 |
|
[BP] GO:0043065 |
positive regulation of apoptotic process
|
BCL2, CYP1B1, F3, GPER1, GRIK5, HCAR2, MMP9, PIK3CB, PPARG, PTGS2, SMAD3, SRC, TOP2A, XDH |
3.21726 |
|
[BP] GO:0043269 |
regulation of ion transport
|
ADORA1, ADRA2A, BCL2, CA2, CA7, DRD1, DRD2, GPER1, GPR35, GRM5, KCNH2, MMP9, PTGS2, SLC6A4 |
3.21052 |
|
[BP] GO:0018193 |
peptidyl-amino acid modification
|
AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A |
3.19941 |
|
[BP] GO:0008210 |
estrogen metabolic process
|
CYP19A1, CYP1B1, HSD17B1, HSD17B2 |
3.1982 |
|
[BP] GO:0019725 |
cellular homeostasis
|
APEX1, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPER1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, POLA1, SMAD3 |
3.19547 |
|
[BP] GO:0006140 |
None
|
ADRA2A, DRD1, DRD2, ESRRB, GPER1, GRM3, GRM8, INSR, PPARA |
3.19547 |
|
[BP] GO:0023052 |
None
|
ADORA1, AR, CHRM2, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, KCNH2, SLC1A1, SLC6A2, TEK |
3.1901 |
|
[BP] GO:0048732 |
gland development
|
AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR |
3.18364 |
|
[BP] GO:0043068 |
positive regulation of programmed cell death
|
BCL2, CYP1B1, F3, GPER1, GRIK5, HCAR2, MMP9, PIK3CB, PPARG, PTGS2, SMAD3, SRC, TOP2A, XDH |
3.17961 |
|
[BP] GO:0007200 |
None
|
ADRA2A, CHRM2, DRD1, DRD2, ESR1, GRM5 |
3.17843 |
|
[BP] GO:0050880 |
None
|
ADORA1, ADRA2A, DRD1, EGFR, GPER1, PTGS2, SLC6A4 |
3.17146 |
|
[BP] GO:0010638 |
positive regulation of organelle organization
|
ALOX15, AURKB, BCL2, GPER1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 |
3.16756 |
|
[BP] GO:0051171 |
regulation of nitrogen compound metabolic process
|
ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
3.16295 |
|
[BP] GO:0051246 |
regulation of protein metabolic process
|
ADORA1, ADRA2A, ALOX15, AR, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
3.15584 |
|
[BP] GO:0035150 |
None
|
ADORA1, ADRA2A, DRD1, EGFR, GPER1, PTGS2, SLC6A4 |
3.15508 |
|
[BP] GO:0010676 |
None
|
ESRRB, GPER1, INSR, PPARA, SRC |
3.14126 |
|
[BP] GO:0010810 |
regulation of cell-substrate adhesion
|
ALOX15, BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK |
3.11633 |
|
[BP] GO:0032147 |
activation of protein kinase activity
|
ADORA1, ADRA2A, DRD2, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PTPN1, SRC |
3.1078 |
|
[BP] GO:0060255 |
regulation of macromolecule metabolic process
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PPARG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
3.09715 |
|
[BP] GO:0007267 |
None
|
ADORA1, AR, CHRM2, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK |
3.09513 |
|
[BP] GO:0050727 |
regulation of inflammatory response
|
ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, PPARA, PPARG, PTGS2, SMAD3, TEK |
3.08212 |
|
[BP] GO:0055080 |
cation homeostasis
|
BCL2, CA2, CA7, DRD1, DRD2, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 |
3.08212 |
|
[BP] GO:0034599 |
cellular response to oxidative stress
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC |
3.02969 |
|
[BP] GO:0001101 |
response to acid chemical
|
AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, PTGS2, SLC6A4, SRC |
3.02689 |
|
[BP] GO:0045934 |
None
|
ADRA2A, APEX1, AR, AURKB, DRD2, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HSPA1A, MMP12, PPARA, PPARG, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 |
3.00835 |
|
[BP] GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway
|
BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC |
2.98953 |
|
[BP] GO:0032845 |
None
|
ADORA1, ADRA2A, BCL2, DRD2, SRC, TNKS, TNKS2 |
2.95846 |
|
[BP] GO:0050678 |
None
|
AR, CDK6, EGFR, F3, KDR, MMP12, PPARG, SMAD3, TEK, XDH |
2.94597 |
|
[BP] GO:0051172 |
None
|
ADRA2A, APEX1, AR, AURKB, CSNK2A1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HSP90AB1, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PPARG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH |
2.92363 |
|
[BP] GO:0043406 |
positive regulation of MAP kinase activity
|
ADORA1, ADRA2A, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC |
2.92363 |
|
[BP] GO:0030817 |
None
|
ADRA2A, DRD1, DRD2, GPER1, GRM3, GRM8 |
2.92177 |
|
[BP] GO:0042752 |
None
|
ADORA1, DRD2, PPARA, PPARG, RORC, TOP2A |
2.92177 |
|
[BP] GO:0040008 |
regulation of growth
|
AR, BCL2, CSNK2A1, DRD2, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, PPARG, SLC6A4, SMAD3, TNKS2 |
2.91782 |
|
[BP] GO:0055082 |
cellular chemical homeostasis
|
BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPER1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3 |
2.91782 |
|
[BP] GO:2001225 |
regulation of chloride transport
|
CA2, CA7, GRM5 |
2.91498 |
|
[BP] GO:0034502 |
protein localization to chromosome
|
AURKB, ESR1, TERT, TNKS, TNKS2 |
2.90869 |
|
[BP] GO:0070988 |
demethylation
|
APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 |
2.90869 |
|
[BP] GO:0071248 |
cellular response to metal ion
|
ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.89546 |
|
[BP] GO:0006352 |
DNA-templated transcription, initiation
|
AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC |
2.88529 |
|
[BP] GO:0043393 |
regulation of protein binding
|
AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, SRC, TERT |
2.88529 |
|
[BP] GO:0010942 |
positive regulation of cell death
|
BCL2, CYP1B1, F3, GPER1, GRIK5, HCAR2, MMP9, PIK3CB, PPARG, PTGS2, SMAD3, SRC, TOP2A, XDH |
2.87003 |
|
[BP] GO:0016042 |
lipid catabolic process
|
ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 |
2.86398 |
|
[BP] GO:0035265 |
organ growth
|
AR, BCL2, CYP19A1, ESR1 |
2.86231 |
|
[BP] GO:1901653 |
cellular response to peptide
|
AKR1B1, APEX1, GPER1, GRM5, IGF1R, INSR, PPARG, SRC |
2.84795 |
|
[BP] GO:0032870 |
cellular response to hormone stimulus
|
ADRA2A, APEX1, AR, EGFR, ESR1, FLT3, GPER1, INSR, PPARG, SRC |
2.82665 |
|
[BP] GO:0072507 |
divalent inorganic cation homeostasis
|
BCL2, DRD1, DRD2, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 |
2.82664 |
|
[BP] GO:0070372 |
regulation of ERK1 and ERK2 cascade
|
ALOX15, DRD2, DUSP3, EGFR, GPER1, KDR, PTPN1, SRC, TEK |
2.82054 |
|
[BP] GO:2001234 |
negative regulation of apoptotic signaling pathway
|
AR, BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT |
2.80791 |
|
[BP] GO:0060736 |
prostate gland growth
|
AR, CYP19A1, ESR1 |
2.79995 |
|
[BP] GO:0019371 |
None
|
PTGS1, PTGS2, TBXAS1 |
2.79995 |
|
[BP] GO:0071900 |
regulation of protein serine/threonine kinase activity
|
ADORA1, ADRA2A, DUSP3, EGFR, FLT3, GRM1, HSP90AB1, IGF1R, INSR, PIK3CB, PTPN1, SRC |
2.78623 |
|
[BP] GO:0032102 |
negative regulation of response to external stimulus
|
ADORA1, CYP19A1, DRD1, DRD2, GPER1, PPARA, PPARG, SMAD3, TEK |
2.76456 |
|
[BP] GO:0032228 |
regulation of synaptic transmission, GABAergic
|
ADORA1, CA2, CA7, DRD2 |
2.76034 |
|
[BP] GO:0009115 |
None
|
AOX1, XDH |
2.76034 |
|
[BP] GO:0006286 |
base-excision repair, base-free sugar-phosphate removal
|
APEX1, POLB |
2.76034 |
|
[BP] GO:0071902 |
positive regulation of protein serine/threonine kinase activity
|
ADORA1, ADRA2A, EGFR, FLT3, GRM1, HSP90AB1, INSR, PIK3CB, PTPN1, SRC |
2.75804 |
|
[BP] GO:0003008 |
None
|
ADORA1, ADRA2A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, EGFR, GPER1, GRM1, GRM5, GRM8, HSD11B2, INSR, KCNH2, PIK3CA, PTGS2, SLC6A4, SRC, TEK, TYR |
2.75103 |
|
[BP] GO:0051701 |
interaction with host
|
AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC |
2.74278 |
|
[BP] GO:0002009 |
morphogenesis of an epithelium
|
AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC |
2.74018 |
|
[BP] GO:0006940 |
None
|
ADORA1, ADRA2A, CHRM2, GPER1, PTGS2 |
2.73725 |
|
[BP] GO:0051926 |
negative regulation of calcium ion transport
|
ADRA2A, BCL2, DRD2, GPR35, PTGS2 |
2.73725 |
|
[BP] GO:0050793 |
regulation of developmental process
|
AR, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F3, GPER1, HSP90AB1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PPARG, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH |
2.72836 |
|
[BP] GO:0042542 |
response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC |
2.72654 |
|
[BP] GO:0010907 |
None
|
ESRRB, INSR, PPARA, SRC |
2.72328 |
|
[BP] GO:0009991 |
response to extracellular stimulus
|
ALPL, AXL, BCL2, CYP1A1, EGFR, HSD11B2, PPARG, PTGS2, SLC6A4, SRC, TYR |
2.72206 |
|
[BP] GO:1903522 |
None
|
ADORA1, ADORA3, ADRA2A, CHRM2, DRD2, EGFR, KCNH2, PTGS2, SLC1A1 |
2.71281 |
|
[BP] GO:0007186 |
G-protein coupled receptor signaling pathway
|
ADORA1, ADORA3, ADRA2A, CA2, CHRM2, DRD1, DRD2, ESR1, GPER1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PIK3CA, PIK3CB, PPARG, SRC |
2.71002 |
|
[BP] GO:0015872 |
None
|
DRD1, SLC6A2, SLC6A4 |
2.7025 |
|
[BP] GO:0070989 |
oxidative demethylation
|
CYP1A2, CYP2D6, CYP3A4 |
2.7025 |
|
[BP] GO:0065007 |
biological regulation
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, APEX1, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
2.66933 |
|
[BP] GO:0045913 |
None
|
ESRRB, GPER1, INSR, PPARA, SRC |
2.65752 |
|
[BP] GO:0051128 |
regulation of cellular component organization
|
ALOX15, AR, AURKB, AXL, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, GPER1, GRIK5, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
2.65752 |
|
[BP] GO:0035556 |
intracellular signal transduction
|
ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, EGFR, GPER1, GRM5, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, POLB, PTPN1, SRC, TEK |
2.64336 |
|
[BP] GO:0021885 |
forebrain cell migration
|
AXL, DRD1, DRD2, EGFR |
2.6345 |
|
[BP] GO:0042737 |
drug catabolic process
|
ACHE, CYP1A2, CYP2A6, CYP2C19, CYP2D6, CYP3A4 |
2.61293 |
|
[BP] GO:0006703 |
estrogen biosynthetic process
|
CYP19A1, HSD17B1, HSD17B2 |
2.60366 |
|
[BP] GO:0051973 |
positive regulation of telomerase activity
|
AURKB, HSP90AA1, HSP90AB1, TNKS |
2.5903 |
|
[BP] GO:1900543 |
None
|
ADRA2A, DRD2, GRM3, GRM8, PPARA |
2.57615 |
|
[BP] GO:0030814 |
None
|
ADRA2A, DRD1, DRD2, GPER1, GRM3, GRM8 |
2.57461 |
|
[BP] GO:0045980 |
None
|
ADRA2A, DRD2, GRM3, GRM8, PPARA |
2.54885 |
|
[BP] GO:0045742 |
None
|
ADORA1, ADRA2A, GPER1, MMP9 |
2.54752 |
|
[BP] GO:0046456 |
icosanoid biosynthetic process
|
ALOX15, ALOX5, PTGS1, PTGS2 |
2.54752 |
|
[BP] GO:0071241 |
cellular response to inorganic substance
|
ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.5411 |
|
[BP] GO:0048871 |
multicellular organismal homeostasis
|
ADORA1, AKR1B1, DRD1, DRD2, MET, PIK3CA |
2.53805 |
|
[BP] GO:0030802 |
None
|
ADRA2A, DRD1, DRD2, GPER1, GRM3, GRM8 |
2.51955 |
|
[BP] GO:0060065 |
uterus development
|
CYP19A1, ESR1, SRC |
2.51167 |
|
[BP] GO:0048869 |
cellular developmental process
|
ACHE, ALPL, AR, AXL, BCL2, CDC25B, CDK6, CES1, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, MET, MMP2, MMP9, PPARG, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A |
2.50455 |
|
[BP] GO:0055065 |
metal ion homeostasis
|
BCL2, DRD1, DRD2, EGFR, ESR1, GPER1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 |
2.50346 |
|
[BP] GO:0071383 |
None
|
AR, EGFR, FLT3, GPER1, SRC |
2.50346 |
|
[BP] GO:0006874 |
cellular calcium ion homeostasis
|
BCL2, DRD1, DRD2, ESR1, GPER1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 |
2.50346 |
|
[BP] GO:2001233 |
regulation of apoptotic signaling pathway
|
AR, BCL2, GPER1, HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT |
2.50346 |
|
[BP] GO:1904018 |
positive regulation of vasculature development
|
CYP1B1, F3, GPER1, KDR, PTGS2, TEK, TERT |
2.50346 |
|
[BP] GO:0051047 |
None
|
ACHE, ADORA1, CYP19A1, DRD2, EGFR, GPER1, HCAR2, MMP12, SLC6A4, SRC |
2.49533 |
|
[BP] GO:0010675 |
None
|
ESRRB, GPER1, INSR, PPARA, RORC, SRC |
2.48796 |
|
[BP] GO:0038128 |
None
|
EGFR, HSP90AA1, PIK3CA, SRC |
2.47164 |
|
[BP] GO:1901186 |
None
|
ADORA1, ADRA2A, GPER1, MMP9 |
2.47164 |
|
[BP] GO:1904705 |
regulation of vascular smooth muscle cell proliferation
|
GPER1, MMP2, MMP9, TERT |
2.47164 |
|
[BP] GO:1901654 |
None
|
AKR1B1, AR, CA9, CSNK2A1, EGFR, PPARG, SRC |
2.46272 |
|
[BP] GO:0031100 |
animal organ regeneration
|
AXL, CSNK2A1, EGFR, FLT3, PPARG |
2.4555 |
|
[BP] GO:0051937 |
None
|
DRD1, SLC6A2, SLC6A4 |
2.43115 |
|
[BP] GO:0070198 |
None
|
TERT, TNKS, TNKS2 |
2.43115 |
|
[BP] GO:0060078 |
None
|
ADORA1, GRIA2, GRIA4, GRIK5, GRM5 |
2.43115 |
|
[BP] GO:0010634 |
positive regulation of epithelial cell migration
|
KDR, MET, MMP9, PTGS2, SRC, TEK |
2.41802 |
|
[BP] GO:0030518 |
intracellular steroid hormone receptor signaling pathway
|
AR, ESR1, ESR2, GPER1, SRC |
2.40718 |
|
[BP] GO:0018958 |
None
|
AKR1B1, BCL2, DRD1, DRD2, TYR |
2.40718 |
|
[BP] GO:0055074 |
calcium ion homeostasis
|
BCL2, DRD1, DRD2, ESR1, GPER1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 |
2.40624 |
|
[BP] GO:0080135 |
regulation of cellular response to stress
|
CDK6, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, TERT, XDH |
2.40624 |
|
[BP] GO:0051094 |
positive regulation of developmental process
|
AR, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, F3, GPER1, HSP90AB1, INSR, KDR, PIM1, PPARG, PTGS2, SMAD3, SRC, TEK, TERT |
2.37154 |
|
[BP] GO:0072503 |
cellular divalent inorganic cation homeostasis
|
BCL2, DRD1, DRD2, ESR1, GPER1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 |
2.36438 |
|
[BP] GO:0030003 |
cellular cation homeostasis
|
BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPER1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 |
2.36438 |
|
[BP] GO:0043268 |
None
|
ADORA1, ADRA2A, DRD1, KCNH2 |
2.36438 |
|
[BP] GO:2000811 |
negative regulation of anoikis
|
BCL2, PIK3CA, SRC |
2.36438 |
|
[BP] GO:0030540 |
female genitalia development
|
AXL, CYP19A1, ESR1 |
2.36438 |
|
[BP] GO:0051131 |
None
|
HSP90AA1, HSP90AB1, HSPA1A |
2.36438 |
|
[BP] GO:0070920 |
None
|
EGFR, ESR1, TERT |
2.36438 |
|
[BP] GO:0019372 |
lipoxygenase pathway
|
ALOX15, ALOX5, PTGS2 |
2.36438 |
|
[BP] GO:1900371 |
None
|
ADRA2A, DRD1, DRD2, GPER1, GRM3, GRM8 |
2.36438 |
|
[BP] GO:0099566 |
None
|
GRM1, GRM5 |
2.36438 |
|
[BP] GO:0098502 |
DNA dephosphorylation
|
APEX1, POLB |
2.36438 |
|
[BP] GO:0009822 |
alkaloid catabolic process
|
CYP2D6, CYP3A4 |
2.36438 |
|
[BP] GO:0046110 |
None
|
AOX1, XDH |
2.36438 |
|
[BP] GO:0032849 |
positive regulation of cellular pH reduction
|
CA2, CA7 |
2.36438 |
|
[BP] GO:0032227 |
negative regulation of synaptic transmission, dopaminergic
|
PTGS2, SLC6A4 |
2.36438 |
|
[BP] GO:1901655 |
None
|
AKR1B1, AR, EGFR, PPARG, SRC |
2.3533 |
|
[BP] GO:1900182 |
positive regulation of protein localization to nucleus
|
EGFR, HSP90AB1, PTGS2, SMAD3, SRC, TERT |
2.35211 |
|
[BP] GO:0030808 |
None
|
ADRA2A, DRD1, DRD2, GPER1, GRM3, GRM8 |
2.35211 |
|
[BP] GO:1903727 |
positive regulation of phospholipid metabolic process
|
FABP3, FLT3, SRC, TEK |
2.33978 |
|
[BP] GO:0061098 |
None
|
ADORA1, ADRA2A, GRM5, PTPN1 |
2.33978 |
|
[BP] GO:0046486 |
glycerolipid metabolic process
|
ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB |
2.33679 |
|
[BP] GO:0002793 |
None
|
ACHE, ADORA1, DRD2, EGFR, GPER1, HCAR2, MMP12, SRC |
2.33144 |
|
[BP] GO:0031667 |
response to nutrient levels
|
ALPL, BCL2, CYP1A1, EGFR, HSD11B2, PPARG, PTGS2, SLC6A4, SRC, TYR |
2.32973 |
|
[BP] GO:0001775 |
cell activation
|
ADRA2A, ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC |
2.3254 |
|
[BP] GO:0002683 |
negative regulation of immune system process
|
ADORA1, ALOX15, AXL, CDK6, CYP19A1, DRD2, DUSP3, GPER1, MMP12, PPARG |
2.32269 |
|
[BP] GO:1904063 |
None
|
ADRA2A, DRD2, GPR35, KCNH2, MMP9 |
2.3147 |
|
[BP] GO:0030155 |
regulation of cell adhesion
|
ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK |
2.30987 |
|
[BP] GO:0030818 |
None
|
ADRA2A, DRD2, GRM3, GRM8 |
2.30987 |
|
[BP] GO:1904355 |
positive regulation of telomere capping
|
AURKB, TNKS, TNKS2 |
2.30612 |
|
[BP] GO:0001504 |
None
|
SLC1A1, SLC6A2, SLC6A4 |
2.30612 |
|
[BP] GO:1901342 |
regulation of vasculature development
|
CYP1B1, F3, GPER1, KDR, PPARG, PTGS2, TEK, TERT, XDH |
2.30293 |
|
[BP] GO:0006873 |
cellular ion homeostasis
|
BCL2, CA2, CA7, DRD1, DRD2, ESR1, GPER1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 |
2.29843 |
|
[BP] GO:0007584 |
response to nutrient
|
ALPL, CYP1A1, EGFR, PPARG, PTGS2, SLC6A4, TYR |
2.29433 |
|
[BP] GO:0001954 |
positive regulation of cell-matrix adhesion
|
CDK6, KDR, SMAD3, TEK |
2.27818 |
|
[BP] GO:0002521 |
leukocyte differentiation
|
AXL, BCL2, FLT3, FUT7, GLO1, MMP9, PPARG, RORC |
2.27636 |
|
[BP] GO:0031099 |
regeneration
|
AXL, BCL2, CSNK2A1, EGFR, FLT3, PPARG |
2.265 |
|
[BP] GO:0042058 |
None
|
ADORA1, ADRA2A, EGFR, GPER1, MMP9 |
2.25355 |
|
[BP] GO:0030803 |
None
|
ADRA2A, DRD2, GRM3, GRM8 |
2.24413 |
|
[BP] GO:0070374 |
positive regulation of ERK1 and ERK2 cascade
|
ALOX15, DRD2, EGFR, GPER1, KDR, SRC, TEK |
2.24413 |
|
[BP] GO:0016137 |
None
|
AKR1B1, AKR1B10, GBA2 |
2.23888 |
|
[BP] GO:0007004 |
None
|
HSP90AA1, HSP90AB1, TERT |
2.23888 |
|
[BP] GO:0030336 |
None
|
ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, PPARG |
2.23765 |
|
[BP] GO:0032868 |
None
|
FABP3, HSD11B2, INSR, PPARA, PPARG, SRC |
2.22143 |
|
[BP] GO:0051384 |
response to glucocorticoid
|
ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 |
2.22143 |
|
[BP] GO:0060249 |
None
|
AKR1B1, APEX1, BCL2, HSP90AA1, HSP90AB1, POLA1, SRC, TERT |
2.22022 |
|
[BP] GO:0060341 |
regulation of cellular localization
|
ADRA2A, AR, BCL2, CSNK2A1, DRD1, DRD2, EGFR, GPER1, GRIK5, HSP90AB1, PTGS2, PTPN1, SMAD3, SRC, TERT |
2.21743 |
|
[BP] GO:0030815 |
None
|
ADRA2A, DRD2, GRM3, GRM8 |
2.18378 |
|
[BP] GO:0030799 |
None
|
ADRA2A, DRD1, DRD2, GPER1, GRM3, GRM8 |
2.17839 |
|
[BP] GO:0051900 |
regulation of mitochondrial depolarization
|
BCL2, KDR, SRC |
2.17839 |
|
[BP] GO:0051588 |
None
|
DRD1, DRD2, GPER1, GRIK5, SLC6A4 |
2.1777 |
|
[BP] GO:0050890 |
None
|
ADORA1, DRD1, DRD2, EGFR, GRM5, INSR, PTGS2, SLC6A4 |
2.17324 |
|
[BP] GO:1904951 |
positive regulation of establishment of protein localization
|
ACHE, BCL2, DRD2, EGFR, GPER1, HCAR2, HSP90AB1, MMP12, PTGS2, SMAD3, SRC |
2.15772 |
|
[BP] GO:1900372 |
None
|
ADRA2A, DRD2, GRM3, GRM8 |
2.1568 |
|
[BP] GO:2000351 |
None
|
GPER1, KDR, TEK, TERT |
2.1568 |
|
[BP] GO:0030809 |
None
|
ADRA2A, DRD2, GRM3, GRM8 |
2.1568 |
|
[BP] GO:0045931 |
positive regulation of mitotic cell cycle
|
APEX1, CDC25B, CYP1A1, DUSP3, INSR, TERT |
2.15231 |
|
[BP] GO:0051234 |
None
|
ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, AR, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, KCNH2, MMP12, MMP9, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, XDH |
2.14763 |
|
[BP] GO:0030800 |
None
|
ADRA2A, DRD2, GRM3, GRM8 |
2.12831 |
|
[BP] GO:0014074 |
response to purine-containing compound
|
APEX1, PPARG, PTGS2, SLC6A4, TEK, TYR |
2.12831 |
|
[BP] GO:0006954 |
inflammatory response
|
ADORA1, ADORA3, ALOX15, AXL, GPER1, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2 |
2.12831 |
|
[BP] GO:1905323 |
None
|
HSP90AA1, HSP90AB1 |
2.12831 |
|
[BP] GO:0033031 |
positive regulation of neutrophil apoptotic process
|
HCAR2, PIK3CB |
2.12831 |
|
[BP] GO:0070213 |
None
|
TNKS, TNKS2 |
2.12831 |
|
[BP] GO:0006145 |
None
|
AOX1, XDH |
2.12831 |
|
[BP] GO:0018894 |
dibenzo-p-dioxin metabolic process
|
CYP1A1, CYP1A2 |
2.12831 |
|
[BP] GO:0051179 |
None
|
ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, EGFR, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, KCNH2, MMP12, MMP9, PPARA, PPARG, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH |
2.12584 |
|
[BP] GO:0048729 |
tissue morphogenesis
|
AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC |
2.11892 |
|
[BP] GO:0010959 |
None
|
ADORA1, ADRA2A, BCL2, DRD1, DRD2, GPER1, GPR35, KCNH2, PTGS2 |
2.11892 |
|
[BP] GO:0034766 |
None
|
ADRA2A, DRD2, GPR35, KCNH2, MMP9 |
2.11138 |
|
[BP] GO:1903532 |
None
|
ACHE, CYP19A1, DRD2, EGFR, GPER1, HCAR2, MMP12, SLC6A4, SRC |
2.11138 |
|
[BP] GO:2000146 |
None
|
ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, PPARG |
2.11033 |
|
[BP] GO:0034762 |
None
|
ADRA2A, BCL2, CA2, DRD1, DRD2, GPER1, GPR35, GRM5, KCNH2, MMP9 |
2.10278 |
|
[BP] GO:0090087 |
None
|
ACHE, ADORA1, ADRA2A, CA2, DRD2, EGFR, GPER1, HCAR2, HSP90AB1, MMP12, PTGS2, PTPN1, SMAD3, SRC |
2.0851 |
|
[BP] GO:0050994 |
None
|
ADORA1, ADRA2A, HCAR2, PPARA |
2.07796 |
|
[BP] GO:0010906 |
None
|
ESRRB, INSR, PPARA, RORC, SRC |
2.07616 |
|
[BP] GO:0003014 |
None
|
ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 |
2.07616 |
|
[BP] GO:0071498 |
cellular response to fluid shear stress
|
CA2, PTGS2, SRC |
2.07616 |
|
[BP] GO:0055093 |
response to hyperoxia
|
CYP1A1, POLB, PPARG |
2.07616 |
|
[BP] GO:0015844 |
None
|
DRD1, SLC6A2, SLC6A4 |
2.07616 |
|
[BP] GO:0051968 |
None
|
DRD1, EGFR, PTGS2 |
2.07616 |
|
[BP] GO:0016311 |
None
|
ALPL, APEX1, BCL2, CA3, CDC25B, DUSP3, POLB, PTPN1 |
2.07616 |
|
[BP] GO:0051480 |
regulation of cytosolic calcium ion concentration
|
DRD1, DRD2, ESR1, GPER1, GPR35, GRM1, GRM5, SMAD3 |
2.06658 |
|
[BP] GO:0050776 |
regulation of immune response
|
ALOX15, BCL2, DRD2, DUSP3, ESR1, HSP90AA1, HSP90AB1, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PPARG, PTPN1, SMAD3, SRC |
2.06554 |
|
[BP] GO:0010632 |
regulation of epithelial cell migration
|
KDR, MET, MMP9, PPARG, PTGS2, SRC, TEK |
2.06015 |
|
[BP] GO:0014066 |
regulation of phosphatidylinositol 3-kinase signaling
|
EGFR, FLT3, GPER1, KDR, TEK |
2.06015 |
|
[BP] GO:0032210 |
regulation of telomere maintenance via telomerase
|
AURKB, SRC, TNKS, TNKS2 |
2.05559 |
|
[BP] GO:0032880 |
regulation of protein localization
|
ACHE, ADRA2A, AR, BCL2, CSNK2A1, DRD2, EGFR, GPER1, HCAR2, HSP90AB1, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT |
2.05027 |
|
[BP] GO:0043266 |
None
|
ADORA1, ADRA2A, DRD1, DRD2, KCNH2 |
2.04161 |
|
[BP] GO:0010628 |
positive regulation of gene expression
|
AR, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, MMP12, PIK3CB, PPARA, PPARG, RORC, SLC6A4, SMAD3, SRC, TERT, TNKS, TOP2A |
2.03491 |
|
[BP] GO:0045766 |
positive regulation of angiogenesis
|
CYP1B1, F3, KDR, PTGS2, TEK, TERT |
2.02852 |
|
[BP] GO:0051893 |
regulation of focal adhesion assembly
|
KDR, SMAD3, SRC, TEK |
2.02852 |
|
[BP] GO:0090109 |
regulation of cell-substrate junction assembly
|
KDR, SMAD3, SRC, TEK |
2.02852 |
|
[BP] GO:1901184 |
None
|
ADORA1, ADRA2A, EGFR, GPER1, MMP9 |
2.0273 |
|
[BP] GO:0022612 |
gland morphogenesis
|
BCL2, EGFR, POLB |
2.0273 |
|
[BP] GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation
|
MMP2, MMP9, TERT |
2.0273 |
|
[BP] GO:0030520 |
intracellular estrogen receptor signaling pathway
|
ESR1, ESR2, SRC |
2.0273 |
|
[BP] GO:0050995 |
None
|
ADORA1, ADRA2A, HCAR2 |
2.0273 |
|
[BP] GO:0030100 |
regulation of endocytosis
|
ALOX15, AXL, DRD2, PIK3CB, PPARG, PTPN1, SRC |
2.02221 |
|
[BP] GO:2001236 |
regulation of extrinsic apoptotic signaling pathway
|
AR, BCL2, GPER1, HSPA1A, SRC, TERT |
2.01964 |
|
[BP] GO:0090066 |
None
|
ADORA1, ADRA2A, ALOX15, DRD1, EGFR, GPER1, HSP90AB1, PTGS2, SLC6A4 |
2.01938 |
|
[BP] GO:0034763 |
None
|
ADRA2A, DRD2, GPR35, KCNH2, MMP9 |
2.01175 |
|
[BP] GO:0000904 |
cell morphogenesis involved in differentiation
|
AR, AXL, MET, SRC, TEK |
2.01175 |
|
[CC] GO:0098590 |
plasma membrane region
|
ADORA1, ADRA2A, CA2, CA4, CA9, CHRM2, DRD1, DRD2, EGFR, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, INSR, MET, PTGS2, SLC1A1, SRC, TEK |
7.34379 |
|
[CC] GO:0044432 |
endoplasmic reticulum part
|
BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, EGFR, F10, FLT3, GBA2, GPER1, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 |
5.76898 |
|
[CC] GO:0016020 |
membrane
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALOX5, ALPL, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TYR |
5.74764 |
|
[CC] GO:0005886 |
plasma membrane
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD1, DRD2, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT |
5.6535 |
|
[CC] GO:0044459 |
plasma membrane part
|
ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA2, CA4, CA9, CHRM2, DRD1, DRD2, DUSP3, EGFR, F10, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KCNH2, KDR, MET, PTGS2, SLC1A1, SLC6A2, SLC6A4, SRC, TEK |
5.38471 |
|
[CC] GO:0005789 |
endoplasmic reticulum membrane
|
BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, EGFR, GBA2, GPER1, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 |
5.24317 |
|
[CC] GO:0044444 |
cytoplasmic part
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, AR, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GRIA2, GRIA4, GRIK5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KCNH2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PPARG, PTGS1, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
4.82324 |
|
[CC] GO:0031226 |
intrinsic component of plasma membrane
|
ADORA1, ADORA3, ADRA2A, AXL, CA4, CHRM2, DRD1, DRD2, F10, F3, FLT3, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A4, TEK |
4.78851 |
|
[CC] GO:0044425 |
membrane part
|
ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A4, SRC, TBXAS1, TEK, TYR |
4.77073 |
|
[CC] GO:0042734 |
None
|
GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 |
3.93106 |
|
[CC] GO:0005887 |
integral component of plasma membrane
|
ADORA1, ADORA3, ADRA2A, AXL, CHRM2, DRD1, DRD2, FLT3, GPER1, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A4, TEK |
3.5782 |
|
[CC] GO:0016323 |
basolateral plasma membrane
|
ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, HSP90AB1, TEK |
3.14762 |
|
[CC] GO:0031253 |
None
|
ADORA1, CA4, CA9, DRD1, DRD2, GPER1, HSP90AA1, HSP90AB1, INSR, SRC |
3.09715 |
|
[CC] GO:0043227 |
membrane-bounded organelle
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GRIA4, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SHBG, SLC1A1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
3.09513 |
|
[CC] GO:0043235 |
receptor complex
|
ADRA2A, EGFR, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R, INSR, SMAD3 |
3.02689 |
|
[CC] GO:0014069 |
None
|
ADORA1, DRD2, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC |
2.97645 |
|
[CC] GO:0099572 |
None
|
ADORA1, DRD2, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC |
2.97645 |
|
[CC] GO:0005783 |
None
|
ADORA1, APEX1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, GPER1, GRIK5, HSPA1A, KDR, PTGS2, PTPN1, XDH |
2.87003 |
|
[CC] GO:0097060 |
None
|
CHRM2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 |
2.69335 |
|
[CC] GO:0044456 |
None
|
ACHE, ADORA1, CHRM2, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4, SRC |
2.67221 |
|
[CC] GO:0043005 |
None
|
ADORA1, CA2, CHRM2, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC6A2, SLC6A4, SRC |
2.64336 |
|
[CC] GO:0120025 |
None
|
ADORA1, AKR1B1, CA2, CDK6, CHRM2, DRD1, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A4, SRC, TEK |
2.62845 |
|
[CC] GO:0043226 |
organelle
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, APEX1, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SHBG, SLC1A1, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
2.35618 |
|
[CC] GO:0044463 |
None
|
ADORA1, AKR1B1, CA4, CA9, CHRM2, DRD1, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC |
2.3533 |
|
[CC] GO:0120038 |
None
|
ADORA1, AKR1B1, CA4, CA9, CHRM2, DRD1, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC |
2.3533 |
|
[CC] GO:0042995 |
cell projection
|
ADORA1, AKR1B1, CA2, CDK6, CHRM2, DRD1, DRD2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A4, SRC, TEK |
2.3496 |
|
[CC] GO:0044446 |
intracellular organelle part
|
AKR1B1, ALOX5, AOX1, APEX1, AR, AURKB, BCL2, CA4, CA5A, CA5B, CA9, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GBA2, GPER1, GRIA2, GRIA4, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, MMP9, NQO2, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR |
2.33679 |
|
[CC] GO:0044422 |
organelle part
|
AKR1B1, ALOX5, AOX1, APEX1, AR, AURKB, BCL2, CA4, CA5A, CA5B, CA9, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GBA2, GPER1, GRIA2, GRIA4, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR |
2.32015 |
|
[CC] GO:0044464 |
cell part
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA7, CA9, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
2.22922 |
|
[CC] GO:0031233 |
None
|
CA4, F10, F3 |
2.12831 |
|
[CC] GO:0031090 |
None
|
ALOX5, BCL2, CA4, CHRM2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, FUT7, GBA2, GPER1, GRIA2, GRIA4, HSP90AB1, INSR, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TNKS, TNKS2, TYR |
2.01304 |
|
[CC] GO:0045121 |
membrane raft
|
EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK |
2.00244 |
|
[MF] GO:0046914 |
transition metal ion binding
|
ALOX15, ALOX5, AOX1, AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PPARG, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH |
20.7273 |
|
[MF] GO:0004089 |
carbonate dehydratase activity
|
CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
17.7491 |
|
[MF] GO:0043167 |
ion binding
|
ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
15.7322 |
|
[MF] GO:0003824 |
catalytic activity
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
13.7917 |
|
[MF] GO:0016835 |
carbon-oxygen lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB |
12.183 |
|
[MF] GO:0043169 |
cation binding
|
ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
11.3471 |
|
[MF] GO:0016836 |
hydro-lyase activity
|
CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
10.8659 |
|
[MF] GO:0008270 |
zinc ion binding
|
AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PPARG, PTPN1, RORC, SMAD3, TNKS |
10.248 |
|
[MF] GO:0038023 |
signaling receptor activity
|
ADORA1, ADORA3, ADRA2A, AR, AXL, CHRM2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PPARG, RORC, TEK |
10.1433 |
|
[MF] GO:0046872 |
metal ion binding
|
ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
10.1415 |
|
[MF] GO:0016491 |
oxidoreductase activity
|
AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH |
9.76231 |
|
[MF] GO:0005506 |
iron ion binding
|
ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, TBXAS1, XDH |
9.70366 |
|
[MF] GO:0020037 |
heme binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 |
9.69086 |
|
[MF] GO:0046906 |
tetrapyrrole binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 |
9.3149 |
|
[MF] GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 |
9.25503 |
|
[MF] GO:0060089 |
molecular transducer activity
|
ADORA1, ADORA3, ADRA2A, AR, AXL, CDK6, CHRM2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PPARG, RORC, TEK |
9.21704 |
|
[MF] GO:0005496 |
steroid binding
|
AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD11B2, HSD17B1, RORC, SHBG |
9.0724 |
|
[MF] GO:0008144 |
drug binding
|
ACHE, AURKB, AXL, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, SLC6A4, SRC, TEK, TOP2A |
9.0364 |
|
[MF] GO:0016829 |
lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB |
9.00398 |
|
[MF] GO:0004872 |
receptor activity
|
ADORA1, ADORA3, ADRA2A, AR, AXL, CHRM2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PPARG, RORC, TEK |
8.93882 |
|
[MF] GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, TBXAS1, TYR |
8.77727 |
|
[MF] GO:0004497 |
monooxygenase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, TBXAS1, TYR |
8.6606 |
|
[MF] GO:0098531 |
transcription factor activity, direct ligand regulated sequence-specific DNA binding
|
AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, PPARG, RORC |
8.60325 |
|
[MF] GO:0004879 |
nuclear receptor activity
|
AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, PPARG, RORC |
8.60325 |
|
[MF] GO:0004871 |
signal transducer activity
|
ADORA1, ADORA3, ADRA2A, AR, AXL, CHRM2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, PPARG, RORC, SMAD3, TEK |
8.5347 |
|
[MF] GO:0048037 |
cofactor binding
|
AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH |
8.06571 |
|
[MF] GO:0070330 |
aromatase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 |
7.99299 |
|
[MF] GO:0003707 |
steroid hormone receptor activity
|
AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PPARA, PPARG, RORC |
7.91427 |
|
[MF] GO:0008066 |
None
|
GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 |
7.48453 |
|
[MF] GO:0019825 |
oxygen binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4 |
7.4173 |
|
[MF] GO:0008395 |
steroid hydroxylase activity
|
CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4 |
6.80723 |
|
[MF] GO:0042562 |
hormone binding
|
ACHE, AR, EGFR, GPER1, HSD17B1, IGF1R, INSR, NQO2, SHBG |
6.60594 |
|
[MF] GO:0004714 |
transmembrane receptor protein tyrosine kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK |
6.39483 |
|
[MF] GO:0099600 |
transmembrane receptor activity
|
ADORA1, ADORA3, ADRA2A, AXL, CHRM2, DRD1, DRD2, EGFR, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK |
6.00239 |
|
[MF] GO:0004888 |
transmembrane signaling receptor activity
|
ADORA1, ADORA3, ADRA2A, AXL, CHRM2, DRD1, DRD2, EGFR, F3, FLT3, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK |
6.00239 |
|
[MF] GO:0008289 |
lipid binding
|
ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, GPER1, HSD11B2, HSD17B1, PPARA, PPARG, RORC, SHBG |
5.88949 |
|
[MF] GO:0019199 |
transmembrane receptor protein kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK |
5.6535 |
|
[MF] GO:0019899 |
enzyme binding
|
ADRA2A, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HSP90AA1, HSP90AB1, HSPA1A, KCNH2, MET, POLA1, POLB, PPARA, PPARG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TNKS2, TOP2A |
5.47697 |
|
[MF] GO:0030235 |
nitric-oxide synthase regulator activity
|
EGFR, ESR1, HSP90AA1, HSP90AB1 |
5.36396 |
|
[MF] GO:0004713 |
protein tyrosine kinase activity
|
AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK |
5.01164 |
|
[MF] GO:0032403 |
protein complex binding
|
ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC |
4.91733 |
|
[MF] GO:0044877 |
macromolecular complex binding
|
ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC |
4.77993 |
|
[MF] GO:0004672 |
protein kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK |
4.75481 |
|
[MF] GO:0030594 |
None
|
CHRM2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 |
4.68983 |
|
[MF] GO:0016772 |
transferase activity, transferring phosphorus-containing groups
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TEK, TERT |
4.62752 |
|
[MF] GO:0042802 |
identical protein binding
|
ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, GRIK5, HSP90AA1, HSP90AB1, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PPARG, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH |
4.51384 |
|
[MF] GO:0043560 |
insulin receptor substrate binding
|
IGF1R, INSR, PIK3CA, PIK3CB |
4.50516 |
|
[MF] GO:0016773 |
phosphotransferase activity, alcohol group as acceptor
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK |
4.35919 |
|
[MF] GO:0097159 |
organic cyclic compound binding
|
ADORA1, ADRA2A, AOX1, APEX1, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SHBG, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, XDH |
4.12166 |
|
[MF] GO:0016614 |
oxidoreductase activity, acting on CH-OH group of donors
|
AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH |
4.02872 |
|
[MF] GO:0016301 |
kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK |
3.87559 |
|
[MF] GO:0030284 |
estrogen receptor activity
|
ESR1, ESR2, GPER1 |
3.84407 |
|
[MF] GO:0046983 |
protein dimerization activity
|
ACHE, ADORA1, ADRA2A, AOX1, AR, AXL, BCL2, DRD2, EGFR, FLT3, HSP90AA1, HSP90AB1, KCNH2, NQO2, PPARG, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH |
3.78827 |
|
[MF] GO:0042803 |
protein homodimerization activity
|
ACHE, ADRA2A, AOX1, BCL2, DRD2, FLT3, HSP90AA1, HSP90AB1, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH |
3.7145 |
|
[MF] GO:0016725 |
oxidoreductase activity, acting on CH or CH2 groups
|
CYP1A2, CYP3A4, XDH |
3.0455 |
|
[MF] GO:0004716 |
signal transducer, downstream of receptor, with protein tyrosine kinase activity
|
EGFR, INSR, KDR |
3.0455 |
|
[MF] GO:0036094 |
small molecule binding
|
ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARG, SLC1A1, SRC, TEK, TOP2A, XDH |
3.0237 |
|
[MF] GO:0033764 |
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.02107 |
|
[MF] GO:0003674 |
molecular_function
|
ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPER1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SHBG, SLC1A1, SLC6A2, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH |
2.99146 |
|
[MF] GO:0016229 |
steroid dehydrogenase activity
|
HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
2.91115 |
|
[MF] GO:0019900 |
None
|
ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, POLA1, PTPN1, SMAD3, SRC, TOP2A |
2.88324 |
|
[MF] GO:0019901 |
None
|
ADRA2A, CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, POLA1, PTPN1, SMAD3, SRC, TOP2A |
2.84987 |
|
[MF] GO:0004666 |
prostaglandin-endoperoxide synthase activity
|
PTGS1, PTGS2 |
2.76034 |
|
[MF] GO:0038052 |
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
|
ESR1, ESR2 |
2.76034 |
|
[MF] GO:0003845 |
None
|
HSD11B1, HSD11B2 |
2.76034 |
|
[MF] GO:0008389 |
None
|
CYP2A13, CYP2A6 |
2.76034 |
|
[MF] GO:0009055 |
electron transfer activity
|
AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH |
2.72654 |
|
[MF] GO:0019902 |
phosphatase binding
|
BCL2, EGFR, MET, PPARA, PPARG, PTPN1, SMAD3 |
2.65752 |
|
[MF] GO:1901363 |
heterocyclic compound binding
|
ADORA1, AOX1, APEX1, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PPARG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, XDH |
2.61376 |
|
[MF] GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
2.51955 |
|
[MF] GO:0050473 |
arachidonate 15-lipoxygenase activity
|
ALOX15, PTGS2 |
2.36438 |
|
[MF] GO:0070576 |
vitamin D 24-hydroxylase activity
|
CYP1A1, CYP3A4 |
2.36438 |
|
[MF] GO:0005330 |
None
|
SLC6A2, SLC6A4 |
2.36438 |
|
[MF] GO:0099583 |
None
|
GRM1, GRM5 |
2.36438 |
|
[MF] GO:0047374 |
None
|
CES1, CES2 |
2.36438 |
|
[MF] GO:0016903 |
None
|
AKR1B1, AKR1B10, AOX1, XDH |
2.30987 |
|
[MF] GO:0008392 |
None
|
CYP2A13, CYP2A6, CYP2C19 |
2.30612 |
|
[MF] GO:0008391 |
None
|
CYP2A13, CYP2A6, CYP2C19 |
2.30612 |
|
[MF] GO:0008134 |
transcription factor binding
|
APEX1, AR, BCL2, ESR1, ESRRB, FLT3, PIM1, PPARA, PPARG, SMAD3, SRC, TERT |
2.24282 |
|
[MF] GO:0000166 |
nucleotide binding
|
AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TEK, TOP2A, XDH |
2.22104 |
|
[MF] GO:1901265 |
nucleoside phosphate binding
|
AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TEK, TOP2A, XDH |
2.22026 |
|
[MF] GO:0035258 |
None
|
ESR1, FLT3, PPARG, SMAD3, SRC |
2.21743 |
|
[MF] GO:0043168 |
anion binding
|
ALOX15, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARG, SLC1A1, SRC, TEK, TOP2A, XDH |
2.21428 |
|
[MF] GO:0004970 |
None
|
GRIA2, GRIA4, GRIK5 |
2.17839 |
|
[MF] GO:0005234 |
None
|
GRIA2, GRIA4, GRIK5 |
2.17839 |
|
[MF] GO:1901338 |
None
|
ADRA2A, DRD1, DRD2 |
2.12831 |
|
[MF] GO:0001223 |
transcription coactivator binding
|
ESR1, PPARA, TERT |
2.12831 |
|
[MF] GO:0034056 |
estrogen response element binding
|
ESR1, ESR2 |
2.12831 |
|
[MF] GO:0034875 |
caffeine oxidase activity
|
CYP1A2, CYP3A4 |
2.12831 |
|
[MF] GO:0004971 |
None
|
GRIA2, GRIA4 |
2.12831 |
|
[MF] GO:0032795 |
None
|
ADORA1, ADRA2A |
2.12831 |
|
[MF] GO:0005497 |
None
|
AR, SHBG |
2.12831 |
|
[MF] GO:0033695 |
oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
|
CYP1A2, CYP3A4 |
2.12831 |
|
[MF] GO:0005524 |
ATP binding
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A |
2.06015 |
