TCM-ID Component

Description of the Component

Component ID	TCMH1496
Latin Name	Rhizoma dryopteris crassirhizomae
English Name	Male fern rhizome
Chinese Pinyin Name	Mian Ma Guan Zhong
中文名	ç»µé©¬è´¯ä¼—
TCM Properties	Minor cold,Bitter
TCM Meridians	Stomach,Liver
Therapeutic Class English
Therapeutic Class Chinese
Functions	remove heat and counteract toxicity, expel intestinal worms, stanch bleeding
Toxicity	Toxic
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID	GBVM2585-11
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx778	Fu Fang Qing Dai Pills	å¤æ–¹é’é»›ä¸¸
TCMFx2198	Guts Decoction
TCMF2545	Hepatitis B Removing Decoction
TCMFx580	Kang Gan Oral Liquid	æŠ—æ„Ÿå£æœæ¶²
TCMFx571	Lian Hua Qing Wen Capsule	è¿žèŠ±æ¸…ç˜Ÿèƒ¶å›Š
TCMFx572	Lian Hua Qing Wen Granules	è¿žèŠ±æ¸…ç˜Ÿé¢—ç²’
TCMFx555	Lian Hua Qing Wen Tablet	è¿žèŠ±æ¸…ç˜Ÿç‰‡
TCMFx4368	Mei Weng Tui Re Granules	æ¢…ç¿é€€çƒé¢—ç²’
TCMFx4376	Mei Weng Tui Re Tablets	æ¢…ç¿é€€çƒç‰‡
TCMFx5051	Tong Ren Da Huo Luo Pills	åŒä»å¤§æ´»ç»œä¸¸
TCMF6825	Yin Lian Qing Gan Recipe	èŒµèŽ²æ¸…è‚åˆå‰‚

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT132	BCHE	Butyrylcholinesterase	Hydrolase	P06276
TCMT17	POLB	DNA polymerase beta	Transferase	P06746
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT232	ABCB1	P-glycoprotein 1	Transporter	P08183
TCMT281	DPP4	Dipeptidyl peptidase IV	Unclassified	P27487
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1218	Staphylococcus aureus
TCMT1229	Enterococcus faecalis
TCMT1232	Pseudomonas aeruginosa
TCMT1246	Escherichia coli
TCMT1463	Mycobacterium tuberculosis

Ingredient Structrues

Ingredient ID: TCMC993
Formula: C19H12O7

Common Name	Daphnoretin
IUPAC Name	7-hydroxy-6-methoxy-3-(2-oxochromen-7-yl)oxychromen-2-one
Canonical SMILES	COc1cc2cc(Oc3ccc4c(c3)oc(=O)cc4)c(=O)oc2cc1O
Standard InCHI	InChI=1S/C19H12O7/c1-23-16-6-11-7-17(19(22)26-15(11)9-13(16)20)24-12-4-2-10-3-5-18(21)25-14(10)8-12/h2-9,20H,1H3
Standard InCHIKey	JRHMMVBOTXEHGJ-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL508494]; PubChem [5281406];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1283	Wikstroemia indica	Liao Ge Wang	äº†å“¥çŽ‹
TCMH1496	Rhizoma dryopteris crassirhizomae	Mian Ma Guan Zhong	ç»µé©¬è´¯ä¼—
TCMH845	Auricularia auricula-judae	Hei Mu Er	é»‘æœ¨è€³
TCMH255	Vigna angularis	Chi Dou	èµ¤è±†
TCMH344	Daphne genkwa	Cu Yuan Hua	é†‹èŠ«èŠ±
TCMH2381	Daphne genkwa	Yuan Hua Zhi Tiao	èŠ«èŠ±æžæ¡
TCMH2263	Isodon amethystoides	Xiang Cha Cai	é¦™èŒ¶èœ
TCMH2378	Daphne genkwa	Yuan Hua	èŠ«èŠ±
TCMH2379	Daphne genkwa	Yuan Hua Gen	èŠ«èŠ±æ ¹
TCMH2380	Daphne genkwa	Yuan Hua Tiao	èŠ«èŠ±æ¡

Ingredient ID: TCMC348
Formula: C27H44O7

Common Name	20-Hydroxyecdysone
IUPAC Name	(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one
Canonical SMILES	O[C@H]1C[C@@]2(C)[C@@H](C[C@H]1O)C(=O)C=C1[C@@H]2CC[C@]2([C@@]1(O)CC[C@@H]2[C@]([C@@H](CCC(O)(C)C)O)(O)C)C
Standard InCHI	InChI=1S/C27H44O7/c1-23(2,32)9-8-22(31)26(5,33)21-7-11-27(34)16-12-18(28)17-13-19(29)20(30)14-24(17,3)15(16)6-10-25(21,27)4/h12,15,17,19-22,29-34H,6-11,13-14H2,1-5H3/t15-,17-,19+,20-,21-,22+,24+,25+,26+,27+/m0/s1
Standard InCHIKey	NKDFYOWSKOHCCO-YPVLXUMRSA-N
External Identifiers	ChEMBL [CHEMBL224128]; PubChem [5459840];
Reference of Component-Ingredient Pair	29126784

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1673	Gentiana macrophylla	Qin Jiao	ç§¦è‰½
TCMH1508	Commiphora myrrha	Mo Yao	æ²¡è¯
TCMH1496	Rhizoma dryopteris crassirhizomae	Mian Ma Guan Zhong	ç»µé©¬è´¯ä¼—
TCMH281	Dipsacus asper	Chuan Duan	å·æ–
TCMH1674	Gentiana straminea	Qin Jiao Hua	ç§¦è‰½èŠ±
TCMH255	Vigna angularis	Chi Dou	èµ¤è±†
TCMH1102	Tinospora capillipes	Jin Guo Lan	é‡‘æžœæ¦„
TCMH202	Bombyx mori	Can Yong	èš•è›¹
TCMH1588	Achyranthes bidentata	Niu Xi	ç‰›è†
TCMH1331	Rhaponticum uniflorum	Lou Lu	æ¼èŠ¦
TCMH1584	Achyranthes bidentata	Niu Teng	ç‰›è—¤
TCMH75	Bombyx mori	Bai Jiang Can	ç™½åƒµèš•
TCMH197	Bombyx mori	Can E	èš•è›¾
TCMH200	Bombyx mori	Can Jian	èš•èŒ§
TCMH201	Bombyx mori	Can Sha	èš•ç ‚
TCMH1652	Paris polyphylla	Qi Ye Yi Zhi Hua	ä¸ƒå¶ä¸€æžèŠ±
TCMH1507	Commiphora myrrha	Mo Xiang	æ²¡é¦™
TCMH2595	Rhododendron micranthum	Zhao Shan Bai	ç…§å±±ç™½
TCMH2576	Paris polyphylla	Zao Xiu	èš¤ä¼‘
TCMH2646	Rhizoma paridis	Chong Lou	é‡æ¥¼
TCMH2362	Artemisia lactiflora	Ya Jiao Ai	é¸è„šè‰¾
TCMH2017	Artemisia lactiflora	Si Ji Cai	å››å£èœ

Ingredient ID: TCMC2421
Formula: C28H46O

Common Name	3-Beta-Hydroxyergost-5,24(28)-Diene
IUPAC Name	(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methyl-5-methylideneheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Canonical SMILES	O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCC(=C)C(C)C)C)C)C1)C
Standard InCHI	InChI=1S/C28H46O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h9,18,20,22-26,29H,3,7-8,10-17H2,1-2,4-6H3/t20-,22+,23+,24-,25+,26+,27+,28-/m1/s1
Standard InCHIKey	INDVLXYUCBVVKW-PXBBAZSNSA-N
External Identifiers	ChEMBL [CHEMBL477971]; PubChem [92113];
Reference of Component-Ingredient Pair	21895454

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1496	Rhizoma dryopteris crassirhizomae	Mian Ma Guan Zhong	ç»µé©¬è´¯ä¼—
TCMH859	Ormosia hosiei	Hong Dou	çº¢è±†
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	æ°´åŠå¤
TCMH943	Rhizoma dioscoreae	Huai Shan Yao	æ·®å±±è¯
TCMH2469	Fritillaria pallidiflora	Yi Bei Mu	ä¼Šè´æ¯
TCMH2134	Smilax glabra	Tu Fu Ling	åœŸèŒ¯è‹“

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC348	C27H44O7	20-Hydroxyecdysone	480.31	-1.1982	3.66	1.049	7	6	138.45	16	4	34	1
TCMC993	C19H12O7	Daphnoretin	352.06	-0.4663	2.78	3.359	2	1	91.29	5	4	26	0
TCMC2421	C28H46O	3-Beta-Hydroxyergost-5,24(28)-Diene	398.35	2.1615	4.43	10.105	1	1	20.23	11	4	29	1

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Rhizoma dryopteris crassirhizomae ç»µé©¬è´¯ä¼—

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC993

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC348

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2421

Occurrence of the ingredient across TCM components

Properties

Download Data