TCM-ID Component

Description of the Component

Component ID	TCMH1496
Latin Name	Rhizoma dryopteris crassirhizomae
English Name	Male fern rhizome
Chinese Pinyin Name	Mian Ma Guan Zhong
中文名	绵马贯众
TCM Properties	Minor cold,Bitter
TCM Meridians	Stomach,Liver
Therapeutic Class English
Therapeutic Class Chinese
Functions	remove heat and counteract toxicity, expel intestinal worms, stanch bleeding
Toxicity	Toxic
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID	GBVM2585-11
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx778	Fu Fang Qing Dai Pills	复方青黛丸
TCMFx2198	Guts Decoction
TCMF2545	Hepatitis B Removing Decoction
TCMFx580	Kang Gan Oral Liquid	抗感口服液
TCMFx571	Lian Hua Qing Wen Capsule	连花清瘟胶囊
TCMFx572	Lian Hua Qing Wen Granules	连花清瘟颗粒
TCMFx555	Lian Hua Qing Wen Tablet	连花清瘟片
TCMFx4368	Mei Weng Tui Re Granules	梅翁退热颗粒
TCMFx4376	Mei Weng Tui Re Tablets	梅翁退热片
TCMFx5051	Tong Ren Da Huo Luo Pills	同仁大活络丸
TCMF6825	Yin Lian Qing Gan Recipe	茵莲清肝合剂

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT132	BCHE	Butyrylcholinesterase	Hydrolase	P06276
TCMT17	POLB	DNA polymerase beta	Transferase	P06746
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT232	ABCB1	P-glycoprotein 1	Transporter	P08183
TCMT281	DPP4	Dipeptidyl peptidase IV	Unclassified	P27487
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1218	Staphylococcus aureus
TCMT1229	Enterococcus faecalis
TCMT1232	Pseudomonas aeruginosa
TCMT1246	Escherichia coli
TCMT1463	Mycobacterium tuberculosis

Ingredient Structrues

Ingredient ID: TCMC993
Formula: C19H12O7

Common Name	Daphnoretin
IUPAC Name	7-hydroxy-6-methoxy-3-(2-oxochromen-7-yl)oxychromen-2-one
Canonical SMILES	COc1cc2cc(Oc3ccc4c(c3)oc(=O)cc4)c(=O)oc2cc1O
Standard InCHI	InChI=1S/C19H12O7/c1-23-16-6-11-7-17(19(22)26-15(11)9-13(16)20)24-12-4-2-10-3-5-18(21)25-14(10)8-12/h2-9,20H,1H3
Standard InCHIKey	JRHMMVBOTXEHGJ-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL508494]; PubChem [5281406];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1283	Wikstroemia indica	Liao Ge Wang	了哥王
TCMH1496	Rhizoma dryopteris crassirhizomae	Mian Ma Guan Zhong	绵马贯众
TCMH845	Auricularia auricula-judae	Hei Mu Er	黑木耳
TCMH2381	Daphne genkwa	Yuan Hua Zhi Tiao	芫花枝条
TCMH255	Vigna angularis	Chi Dou	赤豆
TCMH2263	Isodon amethystoides	Xiang Cha Cai	香茶菜
TCMH344	Daphne genkwa	Cu Yuan Hua	醋芫花
TCMH2378	Daphne genkwa	Yuan Hua	芫花
TCMH2379	Daphne genkwa	Yuan Hua Gen	芫花根
TCMH2380	Daphne genkwa	Yuan Hua Tiao	芫花条

Ingredient ID: TCMC348
Formula: C27H44O7

Common Name	20-Hydroxyecdysone
IUPAC Name	(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one
Canonical SMILES	O[C@H]1C[C@@]2(C)[C@@H](C[C@H]1O)C(=O)C=C1[C@@H]2CC[C@]2([C@@]1(O)CC[C@@H]2[C@]([C@@H](CCC(O)(C)C)O)(O)C)C
Standard InCHI	InChI=1S/C27H44O7/c1-23(2,32)9-8-22(31)26(5,33)21-7-11-27(34)16-12-18(28)17-13-19(29)20(30)14-24(17,3)15(16)6-10-25(21,27)4/h12,15,17,19-22,29-34H,6-11,13-14H2,1-5H3/t15-,17-,19+,20-,21-,22+,24+,25+,26+,27+/m0/s1
Standard InCHIKey	NKDFYOWSKOHCCO-YPVLXUMRSA-N
External Identifiers	ChEMBL [CHEMBL224128]; PubChem [5459840];
Reference of Component-Ingredient Pair	29126784

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1673	Gentiana macrophylla	Qin Jiao	秦艽
TCMH2595	Rhododendron micranthum	Zhao Shan Bai	照山白
TCMH1508	Commiphora myrrha	Mo Yao	没药
TCMH1496	Rhizoma dryopteris crassirhizomae	Mian Ma Guan Zhong	绵马贯众
TCMH281	Dipsacus asper	Chuan Duan	川断
TCMH2576	Paris polyphylla	Zao Xiu	蚤休
TCMH1674	Gentiana straminea	Qin Jiao Hua	秦艽花
TCMH2646	Rhizoma paridis	Chong Lou	重楼
TCMH255	Vigna angularis	Chi Dou	赤豆
TCMH2362	Artemisia lactiflora	Ya Jiao Ai	鸭脚艾
TCMH1102	Tinospora capillipes	Jin Guo Lan	金果榄
TCMH202	Bombyx mori	Can Yong	蚕蛹
TCMH1588	Achyranthes bidentata	Niu Xi	牛膝
TCMH1331	Rhaponticum uniflorum	Lou Lu	漏芦
TCMH1584	Achyranthes bidentata	Niu Teng	牛藤
TCMH75	Bombyx mori	Bai Jiang Can	白僵蚕
TCMH197	Bombyx mori	Can E	蚕蛾
TCMH200	Bombyx mori	Can Jian	蚕茧
TCMH201	Bombyx mori	Can Sha	蚕砂
TCMH1652	Paris polyphylla	Qi Ye Yi Zhi Hua	七叶一枝花
TCMH1507	Commiphora myrrha	Mo Xiang	没香
TCMH2017	Artemisia lactiflora	Si Ji Cai	四季菜

Ingredient ID: TCMC2421
Formula: C28H46O

Common Name	3-Beta-Hydroxyergost-5,24(28)-Diene
IUPAC Name	(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methyl-5-methylideneheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Canonical SMILES	O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCC(=C)C(C)C)C)C)C1)C
Standard InCHI	InChI=1S/C28H46O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h9,18,20,22-26,29H,3,7-8,10-17H2,1-2,4-6H3/t20-,22+,23+,24-,25+,26+,27+,28-/m1/s1
Standard InCHIKey	INDVLXYUCBVVKW-PXBBAZSNSA-N
External Identifiers	ChEMBL [CHEMBL477971]; PubChem [92113];
Reference of Component-Ingredient Pair	21895454

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2469	Fritillaria pallidiflora	Yi Bei Mu	伊贝母
TCMH1496	Rhizoma dryopteris crassirhizomae	Mian Ma Guan Zhong	绵马贯众
TCMH2134	Smilax glabra	Tu Fu Ling	土茯苓
TCMH859	Ormosia hosiei	Hong Dou	红豆
TCMH1984	Typhonium flagelliforme	Shui Ban Xia	水半夏
TCMH943	Rhizoma dioscoreae	Huai Shan Yao	淮山药

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC348	C27H44O7	20-Hydroxyecdysone	480.31	-1.1982	3.66	1.049	7	6	138.45	16	4	34	1
TCMC993	C19H12O7	Daphnoretin	352.06	-0.4663	2.78	3.359	2	1	91.29	5	4	26	0
TCMC2421	C28H46O	3-Beta-Hydroxyergost-5,24(28)-Diene	398.35	2.1615	4.43	10.105	1	1	20.23	11	4	29	1

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Rhizoma dryopteris crassirhizomae 绵马贯众

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC993

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC348

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2421

Occurrence of the ingredient across TCM components

Properties

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