TCM-ID Component

Description of the Component

Component ID	TCMH1283
Latin Name	Wikstroemia indica
English Name	NA
Chinese Pinyin Name	Liao Ge Wang
中文名	了哥王
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID	ITSAJ4502-14
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx3370	Die Da Niu Shang Ling Ding	跌打扭伤灵酊
TCMFx1042	Hou Ji Ling Capsule	喉疾灵胶囊
TCMFx4505	Hou Ji Ling Capsules	喉疾灵胶囊
TCMFx4515	Hou Ji Ling Tablets	喉疾灵片
TCMFx884	Qu Shang Xiao Zhong Tincture	祛伤消肿酊
TCMFx6827	Zhan Jiang She Yao	湛江蛇药

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT17	POLB	DNA polymerase beta	Transferase	P06746
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT281	DPP4	Dipeptidyl peptidase IV	Unclassified	P27487
TCMT31	CYP2C19	Cytochrome P450 2C19	Oxidoreductase	P33261
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2
TCMT80	MAPK1	MAP kinase ERK2	Kinase	P28482
TCMT87	CYP2C9	Cytochrome P450 2C9	Oxidoreductase	P11712

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1230	Human herpesvirus 5
TCMT1438	Plasmodium falciparum

Ingredient Structrues

Ingredient ID: TCMC993
Formula: C19H12O7

Common Name	Daphnoretin
IUPAC Name	7-hydroxy-6-methoxy-3-(2-oxochromen-7-yl)oxychromen-2-one
Canonical SMILES	COc1cc2cc(Oc3ccc4c(c3)oc(=O)cc4)c(=O)oc2cc1O
Standard InCHI	InChI=1S/C19H12O7/c1-23-16-6-11-7-17(19(22)26-15(11)9-13(16)20)24-12-4-2-10-3-5-18(21)25-14(10)8-12/h2-9,20H,1H3
Standard InCHIKey	JRHMMVBOTXEHGJ-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL508494]; PubChem [5281406];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1283	Wikstroemia indica	Liao Ge Wang	了哥王
TCMH1496	Rhizoma dryopteris crassirhizomae	Mian Ma Guan Zhong	绵马贯众
TCMH845	Auricularia auricula-judae	Hei Mu Er	黑木耳
TCMH2381	Daphne genkwa	Yuan Hua Zhi Tiao	芫花枝条
TCMH255	Vigna angularis	Chi Dou	赤豆
TCMH2263	Isodon amethystoides	Xiang Cha Cai	香茶菜
TCMH344	Daphne genkwa	Cu Yuan Hua	醋芫花
TCMH2378	Daphne genkwa	Yuan Hua	芫花
TCMH2379	Daphne genkwa	Yuan Hua Gen	芫花根
TCMH2380	Daphne genkwa	Yuan Hua Tiao	芫花条

Ingredient ID: TCMC718
Formula: C21H24O6

Common Name	Arctigenin
IUPAC Name	(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
Canonical SMILES	COc1cc(ccc1OC)C[C@H]1COC(=O)[C@@H]1Cc1ccc(c(c1)OC)O
Standard InCHI	InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1
Standard InCHIKey	NQWVSMVXKMHKTF-JKSUJKDBSA-N
External Identifiers	ChEMBL [CHEMBL435734]; PubChem [64981];
Reference of Component-Ingredient Pair	21435270

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1283	Wikstroemia indica	Liao Ge Wang	了哥王
TCMH1562	Arctium lappa	Niu Bang Zi	牛蒡子
TCMH2457	Rosa canina	Ye Mei Gui Guo	野玫瑰果
TCMH2381	Daphne genkwa	Yuan Hua Zhi Tiao	芫花枝条
TCMH1376	Trachelospermum jasminoides	Luo Shi Teng	络石藤
TCMH1272	Forsythia suspensa	Lian Qiao	连翘
TCMH2213	Ipomoea cairica	Wu Zhao Long	五爪龙
TCMH344	Daphne genkwa	Cu Yuan Hua	醋芫花
TCMH2378	Daphne genkwa	Yuan Hua	芫花
TCMH2379	Daphne genkwa	Yuan Hua Gen	芫花根
TCMH2380	Daphne genkwa	Yuan Hua Tiao	芫花条

Ingredient ID: TCMC2793
Formula: C31H24O10

Common Name	Sikokianin C
IUPAC Name	(2S,3R)-3-[(2S,3R)-5,7-dihydroxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
Canonical SMILES	COc1ccc(cc1)[C@H]1Oc2cc(O)cc(c2C(=O)[C@@H]1[C@@H]1[C@H](Oc2c(C1=O)c(O)cc(c2)O)c1ccc(cc1)O)O
Standard InCHI	InChI=1S/C31H24O10/c1-39-19-8-4-15(5-9-19)31-27(29(38)25-21(36)11-18(34)13-23(25)41-31)26-28(37)24-20(35)10-17(33)12-22(24)40-30(26)14-2-6-16(32)7-3-14/h2-13,26-27,30-36H,1H3/t26-,27-,30+,31+/m0/s1
Standard InCHIKey	QOPUSVUZHPIYER-TUXGATLDSA-N
External Identifiers	ChEMBL [CHEMBL1172216]; PubChem [10347674];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1283	Wikstroemia indica	Liao Ge Wang	了哥王

Ingredient ID: TCMC2792
Formula: C31H24O10

Common Name	Sikokianin B
IUPAC Name	(2R,3R)-3-[(2R,3S)-5,7-dihydroxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
Canonical SMILES	COc1ccc(cc1)[C@@H]1Oc2cc(O)cc(c2C(=O)[C@H]1[C@@H]1[C@@H](Oc2c(C1=O)c(O)cc(c2)O)c1ccc(cc1)O)O
Standard InCHI	InChI=1S/C31H24O10/c1-39-19-8-4-15(5-9-19)31-27(29(38)25-21(36)11-18(34)13-23(25)41-31)26-28(37)24-20(35)10-17(33)12-22(24)40-30(26)14-2-6-16(32)7-3-14/h2-13,26-27,30-36H,1H3/t26-,27+,30-,31-/m0/s1
Standard InCHIKey	QOPUSVUZHPIYER-JHYZPVKISA-N
External Identifiers	ChEMBL [CHEMBL1172171]; PubChem [49798955];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1283	Wikstroemia indica	Liao Ge Wang	了哥王

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom
TCMC718	C21H24O6	Arctigenin	372.16	-0.5036	3.11	2.934	2	1	74.22	11	3	27
TCMC993	C19H12O7	Daphnoretin	352.06	-0.4663	2.78	3.359	2	1	91.29	5	4	26
TCMC2792	C31H24O10	Sikokianin B	556.14	-3.5793	3.77	1.843	2	5	162.98	10	6	41
TCMC2793	C31H24O10	Sikokianin C	556.14	-3.5793	3.77	1.843	2	5	162.98	10	6	41

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Wikstroemia indica 了哥王

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC993

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC718

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2793

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2792

Occurrence of the ingredient across TCM components

Properties

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