NPASS Compound

Natural Product: NPC232533

Natural Product ID	NPC232533
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	Morphine
IUPAC Name	(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Synonyms	Avinza; Depodur; Infumorph; Kadian; Morphine
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	CHEMBL70
PubChem CID	5288826
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000279] Alkaloids and derivatives [CHEMONTID:0000058] Morphinans

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 40 44 0 0 0 0 0 0 0 0999 V2000 -3.7241 1.0738 -0.4996 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.5955 0.2689 -0.6299 N 0 0 0 0 0 0 0 0 0 0 0 0 -1.9694 0.1735 -1.8856 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.4941 0.0490 -1.9003 C 0 0 0 0 0 0 0 0 0 0 0 0 0.1444 -0.5803 -0.7180 C 0 0 1 0 0 0 0 0 0 0 0 0 -0.9038 -1.1396 0.1845 C 0 0 1 0 0 0 0 0 0 0 0 0 -0.3831 -1.9060 1.3074 C 0 0 0 0 0 0 0 0 0 0 0 0 0.7367 -2.5889 1.1624 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5037 -2.6213 -0.0921 C 0 0 1 0 0 0 0 0 0 0 0 0 1.2945 -1.4998 -1.0294 C 0 0 2 0 0 0 0 0 0 0 0 0 2.4410 -0.6160 -1.1028 O 0 0 0 0 0 0 0 0 0 0 0 0 2.2010 0.4196 -0.1829 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9921 1.3413 0.4781 C 0 0 0 0 0 0 0 0 0 0 0 0 2.4076 2.2568 1.3528 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0254 2.2436 1.5620 C 0 0 0 0 0 0 0 0 0 0 0 0 0.2461 1.3307 0.9065 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2149 1.2254 1.0623 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.8312 -0.0069 0.5294 C 0 0 1 0 0 0 0 0 0 0 0 0 0.8647 0.4580 0.0622 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3604 1.3187 0.2409 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8745 -2.6247 0.2600 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.6266 0.4203 -0.3133 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.8902 1.7405 -1.3663 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.6456 1.7119 0.4157 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.3980 -0.7077 -2.4292 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.2583 1.0554 -2.4983 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.0103 1.0324 -2.0793 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.1766 -0.5671 -2.7975 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.5171 -1.8532 -0.4439 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.8952 -1.9226 2.2460 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1443 -3.1758 2.0056 H 0 0 0 0 0 0 0 0 0 0 0 0 1.3679 -3.6010 -0.6369 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1587 -1.8727 -2.0637 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0319 2.9840 1.8742 H 0 0 0 0 0 0 0 0 0 0 0 0 0.5493 2.9540 2.2446 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.6476 2.1095 0.5186 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.4803 1.4323 2.1357 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.5318 -0.4095 1.3202 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8285 2.0843 -0.2157 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0209 -1.9911 1.0157 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 1 0 5 4 1 6 5 6 1 0 6 7 1 0 7 8 2 0 8 9 1 0 9 10 1 0 10 11 1 0 11 12 1 0 12 13 2 0 13 14 1 0 14 15 2 0 15 16 1 0 16 17 1 0 17 18 1 0 16 19 2 0 13 20 1 0 9 21 1 0 18 2 1 0 19 5 1 0 10 5 1 0 19 12 1 0 18 6 1 0 1 22 1 0 1 23 1 0 1 24 1 0 3 25 1 0 3 26 1 0 4 27 1 0 4 28 1 0 6 29 1 6 7 30 1 0 8 31 1 0 9 32 1 6 10 33 1 6 14 34 1 0 15 35 1 0 17 36 1 0 17 37 1 0 18 38 1 1 20 39 1 0 21 40 1 0 M END

Standard InCHIKey	BQJCRHHNABKAKU-KBQPJGBKSA-N
Standard InCHI	InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
SMILES	CN1CC[C@]23[C@H]4C=C[C@@H]([C@@H]3Oc3c(ccc(C[C@@H]14)c23)O)O

Calculated Properties

Physi-Chem Properties

Molecular Weight:	285.14	Volume:	286.628 ? Van der Waals volume.
Dense:	0.995	LogP:	1.089 ? The logarithm of the n-octanol/water distribution coefficients.
logD7.4:	1.315 ? The logarithm of the n-octanol/water distribution coefficient at pH=7.4.	LogS:	-2.713 ? The logarithm of aqueous solubility value.
Rotatable Bonds:	0.0	Rigid Bonds:	22.0
TPSA:	52.93 ? Topological Polar Surface Area.	H-Bond Acceptor:	4.0
H-Bond Donor:	2.0	Rings:	5.0
Heavy Atoms:	4.0

MedChem Properties

QED Drug-Likeness Score:	0.703	GASA:	1.0 ? GASA represents the probability of being difficult to synthesize, ranging from 0 to 1.
Synthetic Accessibility Score:	5.274	Fsp³:	0.529
MCE-18:	124.615 ? MCE-18 stands for medicinal chemistry evolution.MCE-18≥45 is considered a suitable value.	Lipinski Rule-of-5:	Rejected
Pfizer Rule:	Rejected	GSK Rule:	Rejected
Golden Triangle Rule:	Rejected	BMS Rule:	0
Chelating Alert:	1	PAINS Alert:	0
Colloidal aggregators:	0.685	Fluc inhibitor:	0.016 ? The fluc inhibitor value is the probability of being fLuc inhibitors, within the range of 0 to 1.
Blue fluorescence:	0.132 ? The blue fluorescence value is the probability of being blue fluorescence, within the range of 0 to 1	Green fluorescence:	0.035 ? The green fluorescence value is the probability of being green fluorescence, within the range of 0 to 1
Reactive compounds:	0.015	Promiscuous compounds:	0.145

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

Caco-2 Permeability:	-4.97	MDCK Permeability:	-4.684
Pgp-inhibitor:	0.0	Pgp-substrate:	0.99
PAMPA:	0.543 ? The experimental data for Peff was logarithmically transformed (logPeff). Molecules with log Peff values below 2.0 were classified as low-permeability (Category 0), while those with log Peff values exceeding 2.5 were classified as high-permeability (Category 1).	Human Intestinal Absorption (HIA):	0.0
20% Bioavailability (F20%):	0.314	30% Bioavailability (F30%):	1.0
50% Bioavailability (F50%):	1.0

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	1.0	MRP1:	0.949
Plasma Protein Binding (PPB):	17.924%	Volume Distribution (VD):	0.271
Fu:	75.378% ? The fraction unbound in plasms.	OATP1B1 inhibitor:	0.022
OATP1B3 inhibitor:	0.001	BCRP inhibitor:	0.001
BSEP inhibitor:	0.0

ADMET: Metabolism

CYP1A2-inhibitor:	0.865	CYP1A2-substrate:	0.002
CYP2C19-inhibitor:	0.983	CYP2C19-substrate:	0.001
CYP2C9-inhibitor:	0.165	CYP2C9-substrate:	0.37
CYP2D6-inhibitor:	0.999	CYP2D6-substrate:	0.002
CYP3A4-inhibitor:	0.998	CYP3A4-substrate:	0.086
CYP2B6-substrate:	0.0	CYP2C8-inhibitor:	0.001
HLM stability:	0.074 ? Human liver microsomal (HLM) stability. Category 0: stable+ (HLM > 30 min); Category 1: unstable- (HLM ≤ 30 min). The output value is the probability of human liver microsomal instability, where a value closer to 1 indicates a higher likelihood of instability.

ADMET: Excretion

Clearance (CL):

22.825

Half-life (T1/2):

3.006

ADMET: Toxicity

hERG Blockers:	0.121	hERG Blockers (10um):	0.406
Human Hepatotoxicity (H-HT):	0.641	Drug-induced Liver Injury (DILI):	0.085
AMES Toxicity:	0.618	Rat Oral Acute Toxicity:	0.652
Maximum Recommended Daily Dose:	0.693	Skin Sensitization:	0.904
Carcinogencity:	0.386	Eye Corrosion:	0.041
Eye Irritation:	0.869	Respiratory Toxicity:	0.936
Drug-induced Neurotoxicity:	0.284	Ototoxicity:	0.489
Hematotoxicity:	0.246	Drug-induced Nephrotoxicity:	0.218
Genotoxicity:	0.528	RPMI-8226 Immunitoxicity:	0.071
A549 Cytotoxicity:	0.048	Hek293 Cytotoxicity:	0.258
BCF:	0.662 ? Bioconcentration factors are used for considering secondary poisoning potential and assessing risks to human health via the food chain. The unit is -log10[(mg/L)/(1000*MW)].	IGC50:	3.296 ? 48 hour Tetrahymena pyriformis IGC50. The unit of IGC50 is -log10[(mg/L)/(1000*MW)].
LC50DM:	4.909 ? 48 hour Daphnia magna LC50. The unit of LC50DM is -log10[(mg/L)/(1000*MW)].	LC50FM:	4.083 ? 96 hour fathead minnow LC50. The unit of LC50FM is -log10[(mg/L)/(1000*MW)].

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO12012	Saururus cernuus	Species	Saururaceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1016/S0040-4039(01)99818-1]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1042/BA20020118]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	DOI[10.1556/abot.45.2003.3-4.15]
NPO19205	Buxus sempervirens	Species	Buxaceae	Eukaryota	roots	n.a.	n.a.	PMID[10346940]
NPO11944	Incarvillea sinensis	Species	Bignoniaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[10514316]
NPO12012	Saururus cernuus	Species	Saururaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[11421725]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15019787]
NPO12012	Saururus cernuus	Species	Saururaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15165135]
NPO3983	Piper futokadsura	Species	Piperaceae	Eukaryota	n.a.	aerial part	n.a.	PMID[15635246]
NPO223	Rhaponticum carthamoides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[15730237]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	flowers	n.a.	n.a.	PMID[15974620]
NPO664	Potentilla multifida	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17504571]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[17580910]
NPO9576	Bufo bufo	Species	Bufonidae	Eukaryota	n.a.	n.a.	n.a.	PMID[21185919]
NPO11885	Dysoxylum lenticellatum	Species	Meliaceae	Eukaryota	twigs and leaves	Yunnan Province, China	2008-OCT	PMID[21954912]
NPO11885	Dysoxylum lenticellatum	Species	Meliaceae	Eukaryota	n.a.	leaf	n.a.	PMID[21954912]
NPO11885	Dysoxylum lenticellatum	Species	Meliaceae	Eukaryota	n.a.	twig	n.a.	PMID[21954912]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[21954931]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[22029392]
NPO10672	Vitex megapotamica	Species	Lamiaceae	Eukaryota	n.a.	leaf	n.a.	PMID[22708620]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23270478]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[23517479]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[25396337]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	Roots	n.a.	n.a.	PMID[26599832]
NPO19205	Buxus sempervirens	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[26722868]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[27295506]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	Leaves	n.a.	n.a.	PMID[29272126]
NPO21950	Rhododendron decorum	Species	Ericaceae	Eukaryota	Leaves; Twigs	n.a.	n.a.	PMID[29757638]
NPO40322	Rhododendron auriculatum	Species	Ericaceae	Eukaryota	Leaves	n.a.	n.a.	PMID[31246460]
NPO18636	Cupressus macrocarpa	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	PMID[32223924]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	PMID[37685099]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO223	Rhaponticum carthamoides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2466	Aloe microstigma	Species	Asphodelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7312	Aplidium multiplicatum	Species	Polyclinidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10176	Chrozophora prostrata	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO19205	Buxus sempervirens	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12012	Saururus cernuus	Species	Saururaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2917	Artemisia oranensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO21463	Aruncus dioicus	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9576	Bufo bufo	Species	Bufonidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12952	Cabucala madagascariensis	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7884	Centaurea amara	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9398	Cortinarius rubellus	Species	Cortinariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO18636	Cupressus macrocarpa	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11885	Dysoxylum lenticellatum	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO4797	Gavia immer	Species	Gaviidae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12735	Halimeda macroloba	Species	Halimedaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO7543	Haplopappus venetus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO2498	Kochia trichophylla	Species	Chenopodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO5177	Lecanora conizaeoides	Species	Lecanoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6887	Lytanthus salicinus	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10043	Phebalium ozothamnoides	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO3983	Piper futokadsura	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO6011	Pleurotus citrinopileatus	Species	Pleurotaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO664	Potentilla multifida	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11515	Streptomyces plumbeus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]
NPO12250	Strychnos fendleri	Species	Loganiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO26231	Vicia villosa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO10672	Vitex megapotamica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO11944	Incarvillea sinensis	Species	Bignoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[COCONUT]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	Latex Exudate	n.a.	n.a.	Database[FooDB]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	Seed	n.a.	n.a.	Database[FooDB]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota		n.a.	n.a.	Database[FooDB]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.		Database[FooDB]
NPO12012	Saururus cernuus	Species	Saururaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO19205	Buxus sempervirens	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO223	Rhaponticum carthamoides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO11944	Incarvillea sinensis	Species	Bignoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[HerDing]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO223	Rhaponticum carthamoides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO12012	Saururus cernuus	Species	Saururaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO19205	Buxus sempervirens	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO11944	Incarvillea sinensis	Species	Bignoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO10672	Vitex megapotamica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO18636	Cupressus macrocarpa	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCMID]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO19205	Buxus sempervirens	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO223	Rhaponticum carthamoides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO12012	Saururus cernuus	Species	Saururaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9576	Bufo bufo	Species	Bufonidae	Eukaryota	n.a.	n.a.	n.a.	Database[TCM_Taiwan]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[TM-MC]
NPO9576	Bufo bufo	Species	Bufonidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2498	Kochia trichophylla	Species	Chenopodiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12012	Saururus cernuus	Species	Saururaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6011	Pleurotus citrinopileatus	Species	Pleurotaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11885	Dysoxylum lenticellatum	Species	Meliaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7884	Centaurea amara	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11515	Streptomyces plumbeus	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[UNPD]
NPO7312	Aplidium multiplicatum	Species	Polyclinidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2917	Artemisia oranensis	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12250	Strychnos fendleri	Species	Loganiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO2466	Aloe microstigma	Species	Asphodelaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO4797	Gavia immer	Species	Gaviidae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO11944	Incarvillea sinensis	Species	Bignoniaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10043	Phebalium ozothamnoides	Species	Rutaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO5177	Lecanora conizaeoides	Species	Lecanoraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO6887	Lytanthus salicinus	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.	Database[UNPD]
NPO12735	Halimeda macroloba	Species	Halimedaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9398	Cortinarius rubellus	Species	Cortinariaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO19205	Buxus sempervirens	Species	Buxaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21463	Aruncus dioicus	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO18636	Cupressus macrocarpa	Species	Cupressaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10176	Chrozophora prostrata	Species	Euphorbiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO664	Potentilla multifida	Species	Rosaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO26231	Vicia villosa	Species	Fabaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO7543	Haplopappus venetus	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO3983	Piper futokadsura	Species	Piperaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO10672	Vitex megapotamica	Species	Lamiaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO12952	Cabucala madagascariensis	Species	Apocynaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO223	Rhaponticum carthamoides	Species	Asteraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO9498	Papaver somniferum	Species	Papaveraceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO1680	Physalis angulata	Species	Solanaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO25980	Rhododendron molle	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]
NPO21950	Rhododendron decorum	Species	Ericaceae	Eukaryota	n.a.	n.a.	n.a.	Database[UNPD]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
Relative molar potency	3
Ki	231
IC50	114
Ratio	43
Inhibition	36
Relative potency	22
Potency ratio	1
Relative affinity	3
Kt	2
ln Kt	1
ln Kp	1
Dose ratio	2
ED50 ratio	1
Activity	143
EC50	70
Log AP	1
ED50	301
Control	2
Emax	35
Log10ED50	2
KiH	1
KiL	1
Ratio IC50	2
deltalog(Tau/KA)	3
FC	5
Efficacy	4
pEC50	2
Molar potency	1
Selectivity	7
Selectivity ratio	2
Ki ratio	1
Ratio Ki	19
Kin	1
Vdu	1
HepSE_bilirubinemia	1
HepSE_cholecystitis	1
HepSE_cholelithiasis	1
HepSE_cirrhosis	1
HepSE_hepatic failure	1
HepSE_hepatic necrosis	1
HepSE_hepatomegaly	1
HepSE_jaundice	2
HepSE_liver fatty	1
HepSE_liver function tests abnormal	1
HepSE_Combined Scores	1
Retention_time	2
Ratio EC50	2
HepSE_liver disease	1
ID50	5
Duration	11
A50	8
ED2sec	1
AUEC	2
MPE50	8
MPE	20
Kd	2
Effect	1
DOSE	1
MAD	2
MNTD	2
Analgesic efficacy compared to morphine	1
Analgesic efficacy compared to epibatidine	1
MED50	1
Potency vs EKC	1
Ke naloxone	1
Antinociception	2
Time of licking	2
Licking latency	4
Analgesic effect	1
Antagonism	1
Relative analgesic potency	1
Hind-paw lick latency time	1
Analgesia	1
Latency	3
AD50	7
TIME	13
HepSE_elevated liver function tests	1
HepSE_hepatitis	1
%max	1
Ratio ED50	5
GPI	1
Potency	1
pD2	2
Contraction	1

Activity Type	# Activity
Individual protein	482
Protein family	39
Single protein	2
Others	83
Tissue	3
Organism	563
Unchecked	3
Non-molecular	4
Protein complex	4
Phenotype	15

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	2.1	nM	PMID[2170652]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	5.7	nM	PMID[2831363]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	167.0	nM	PMID[2831363]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	0.88	nM	PMID[19027293]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	140.0	nM	PMID[22439881]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	24.0	nM	PMID[19027293]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	301.0	nM	PMID[1323679]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.3	nM	PMID[1323679]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	456.0	nM	PMID[1323679]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	0.78	nM	PMID[12643945]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	4.8	nM	PMID[12643945]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	38.0	nM	PMID[9873439]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	1870.0	nM	PMID[9873439]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	375.0	nM	PMID[7932535]
NPT296	Individual protein	Sigma opioid receptor	Homo sapiens	Ki	>	100000.0	nM	PMID[7932535]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	71.6	nM	PMID[1967312]
NPT1167	Individual protein	Delta opioid receptor	Mus musculus	IC50	=	736.0	nM	PMID[1967312]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	7.71	nM	PMID[1967312]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	629.51	nM	PMID[1967312]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	151.0	nM	PMID[1846921]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	64.0	nM	PMID[12930147]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.0	nM	PMID[12930147]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	3.0	nM	PMID[12930147]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	299.0	nM	PMID[12930147]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	86.0	nM	PMID[2567782]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	1.8	nM	PMID[2567782]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ratio	=	0.021	n.a.	PMID[2567782]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	IC50	=	1.94	nM	PMID[7739011]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	IC50	=	271.0	nM	PMID[8642567]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	0.88	nM	PMID[22439881]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	24.0	nM	PMID[22439881]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	1.8	nM	PMID[11425550]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Ratio	=	3.0	n.a.	PMID[8394935]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	IC50	=	130.0	nM	DOI[10.1016/S0960-894X(01)80277-8]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	8.5	nM	DOI[10.1016/S0960-894X(01)80277-8]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	IC50	=	430.0	nM	DOI[10.1016/S0960-894X(01)80277-8]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	IC50	=	0.14	nM	PMID[7739011]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	IC50	=	1.82	nM	PMID[7739011]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	17.0	nM	PMID[12166947]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	150.0	nM	PMID[12166947]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	260.0	nM	PMID[12166947]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	11.0	nM	PMID[14998329]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	188.0	nM	PMID[14998329]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	IC50	=	2390.0	nM	PMID[1846918]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	1.0	nM	PMID[12570383]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.467	nM	PMID[11960505]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	416.87	nM	PMID[11960505]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	467.74	nM	PMID[11960505]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Relative affinity	=	98.5	%	PMID[11960505]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Relative affinity	=	0.8	%	PMID[11960505]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Relative affinity	=	0.7	%	PMID[11960505]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Relative potency	=	100.0	n.a.	PMID[7154002]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	57.3	nM	PMID[7154002]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	IC50	=	150.0	nM	PMID[12502358]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	IC50	=	1705.1	nM	PMID[12502358]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	IC50	=	0.57	nM	PMID[12502358]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ratio	=	265.0	n.a.	PMID[12502358]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	70.0	nM	PMID[6276540]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	2.15	nM	PMID[2828622]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	2.8	nM	PMID[10841790]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	IC50	=	1420.0	nM	PMID[6090663]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	6.55	nM	PMID[21235243]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	86.0	nM	PMID[2832603]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	1.8	nM	PMID[2832603]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Kt	=	150000000.0	n.a.	PMID[2999404]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	ln Kt	=	18.8	n.a.	PMID[2999404]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	ln Kp	=	12.6	n.a.	PMID[2999404]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	8.14	nM	PMID[7739013]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	69.1	nM	PMID[7739013]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	460.0	nM	PMID[1846921]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	1900.0	nM	DOI[10.1016/S0960-894X(00)80398-4]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	38.0	nM	DOI[10.1016/S0960-894X(00)80398-4]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	51.0	nM	DOI[10.1016/S0960-894X(00)80398-4]
NPT296	Individual protein	Sigma opioid receptor	Homo sapiens	Ki	>	10000.0	nM	DOI[10.1016/S0960-894X(00)80398-4]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Dose ratio	=	45.0	n.a.	PMID[1310115]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Dose ratio	=	7.5	n.a.	PMID[1310115]
NPT1167	Individual protein	Delta opioid receptor	Mus musculus	ED50 ratio	=	1.25	n.a.	PMID[2160532]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	4.0	nM	PMID[2887656]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Relative potency	=	1.0	n.a.	PMID[2887656]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	IC50	=	185.0	nM	PMID[2887656]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Relative potency	=	1.0	n.a.	PMID[2887656]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	IC50	=	530.0	nM	PMID[2887656]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	77.0	nM	PMID[6313921]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Relative Potency	=	1.0	n.a.	PMID[6313921]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	132.0	nM	PMID[8642554]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	330.0	nM	PMID[8642554]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	IC50	=	1.6	nM	PMID[1671414]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	3.96	nM	PMID[12372519]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	52.14	nM	PMID[12372519]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	113.3	nM	PMID[12372519]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Activity	=	62.0	n.a.	PMID[7515442]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Activity	=	31.0	n.a.	PMID[7515442]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	IC50	=	3.9	nM	PMID[1851843]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	38.0	nM	PMID[1851843]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	710.0	nM	PMID[9873603]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	6.51	nM	PMID[9873603]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	110.0	nM	PMID[9873603]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	EC50	=	21.3	nM	PMID[9873603]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	280.0	nM	PMID[1315868]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	49.0	nM	PMID[1315868]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	33.0	nM	PMID[1315868]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	510.0	nM	PMID[9873439]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	6424.0	nM	PMID[8390575]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	36.0	nM	PMID[8390575]
NPT1167	Individual protein	Delta opioid receptor	Mus musculus	IC50	=	390.0	nM	PMID[6276540]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	58.8	nM	PMID[12166947]
NPT1167	Individual protein	Delta opioid receptor	Mus musculus	IC50	=	644.0	nM	PMID[12166947]
NPT109	Individual protein	Cytochrome P450 3A4	Homo sapiens	IC50	>	50000.0	nM	PMID[12699389]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	IC50	>	50000.0	nM	PMID[12699389]
NPT1456	Individual protein	P-glycoprotein 1	Mus musculus	IC50	>	50000.0	nM	PMID[12699389]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	Ratio	=	1.0	n.a.	PMID[12699389]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	Ratio	=	1.5	n.a.	PMID[12699389]
NPT1455	Individual protein	P-glycoprotein 3	Mus musculus	Ratio	=	2.4	n.a.	PMID[12699389]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	113.0	nM	PMID[12699394]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	KT	=	18.8	n.a.	PMID[2831361]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	2.0	nM	PMID[8064796]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	3.0	nM	DOI[10.1016/0960-894X(95)00077-7]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Ki	=	1.8	nM	PMID[15482911]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Ratio	=	0.02	n.a.	PMID[15482911]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	113.0	nM	PMID[15857143]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	311.0	nM	PMID[15857143]
NPT1167	Individual protein	Delta opioid receptor	Mus musculus	IC50	=	1600.0	nM	PMID[15857143]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Activity	=	62.0	%	PMID[21235243]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	EC50	=	484.0	nM	PMID[21235243]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Activity	=	103.0	%	PMID[19253983]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	EC50	=	316.0	nM	PMID[19253983]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Activity	=	93.0	%	PMID[19253983]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	15.6	nM	PMID[19253983]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	46.9	nM	PMID[17887741]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	33.9	nM	PMID[16777416]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	58.0	nM	PMID[16777416]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	2.5	nM	PMID[16777416]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	1.1	nM	PMID[17887741]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	ED50	=	37.0	nM	PMID[20055417]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	86.0	%	PMID[17625813]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	316.0	nM	PMID[21235243]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	202.0	%	PMID[18062664]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Log10ED50	=	7.13	n.a.	PMID[18062664]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Emax	=	134.0	%	PMID[18062664]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Log10ED50	=	7.09	n.a.	PMID[18062664]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	EC50	=	395.0	nM	PMID[17962026]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	100.0	%	PMID[27958743]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	6.0	nM	PMID[17616524]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	4.0	nM	PMID[17616524]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	6.4	nM	PMID[17616524]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	7.0	nM	PMID[17616524]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	65.5	nM	PMID[18311899]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	104.57	nM	PMID[18311899]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	1.7	nM	PMID[18311899]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	IC50	=	9770.0	nM	PMID[18370374]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	29300.0	nM	PMID[18370374]
NPT1167	Individual protein	Delta opioid receptor	Mus musculus	IC50	=	155000.0	nM	PMID[18370374]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	IC50	=	1.27	nM	PMID[18337104]
NPT1167	Individual protein	Delta opioid receptor	Mus musculus	IC50	<	500.0	nM	PMID[18337104]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	IC50	<	500.0	nM	PMID[18337104]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	KiH	=	2.5	nM	PMID[19351163]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	KiL	=	113.0	nM	PMID[19351163]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	IC50	=	213.1	nM	PMID[18990576]
NPT1167	Individual protein	Delta opioid receptor	Mus musculus	IC50	>	1000.0	nM	PMID[18990576]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	IC50	=	1.271	nM	PMID[18990576]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	2.55	nM	PMID[21684752]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Emax	=	28.0	%	PMID[20055417]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Emax	=	103.0	%	PMID[20055417]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	ED50	=	316.0	nM	PMID[20055417]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	ED50	=	1140.0	nM	PMID[20055417]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	6.9	nM	PMID[19932964]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	116.8	nM	PMID[19932964]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	EC50	=	123.5	nM	PMID[19932964]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Activity	=	209.0	%	PMID[19932964]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Emax	=	24.41	%	PMID[20413312]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	EC50	=	85.5	nM	PMID[20413312]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	IC50	=	5.64	nM	PMID[20413312]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	33.7	nM	PMID[20478711]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	>	10000.0	nM	PMID[20580236]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	>	10000.0	nM	PMID[20580236]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Activity	=	93.0	%	PMID[21235243]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Activity	=	103.0	%	PMID[21235243]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	EC50	=	15.6	nM	PMID[21235243]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	2.2	nM	PMID[21481987]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	1.98	nM	PMID[21641219]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	54.3	nM	PMID[21641219]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	1.1	nM	PMID[21641798]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	46.9	nM	PMID[21641798]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	4.6	nM	PMID[21621410]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	2.52	nM	PMID[21621410]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	1.92	nM	PMID[21621410]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	2.6	nM	PMID[25599950]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	605.0	nM	PMID[25599950]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	299.0	nM	PMID[25599950]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	2.2	nM	PMID[24900459]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	3.7	nM	PMID[24900459]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	0.14	nM	PMID[22680612]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	295.0	nM	PMID[22680612]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	13.3	nM	PMID[22680612]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	77.0	%	PMID[22995061]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	IC50	=	4.3	nM	PMID[22995061]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Emax	=	57.0	%	PMID[23419026]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	60.9	nM	PMID[23419026]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	EC50	=	194.0	nM	PMID[23419026]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	6.3	nM	PMID[23419026]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	468.0	nM	PMID[23517479]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.5	nM	PMID[23517479]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Inhibition	=	97.0	%	PMID[23880538]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Inhibition	=	91.0	%	PMID[23880538]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Inhibition	=	90.0	%	PMID[23880538]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Inhibition	=	69.0	%	PMID[23880538]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	EC50	=	500.0	nM	PMID[23880538]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	EC50	=	400.0	nM	PMID[23880538]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	50.0	nM	PMID[23880538]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	EC50	=	30.0	nM	PMID[23880538]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	501.19	nM	PMID[24063433]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	39.81	nM	PMID[24063433]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	IC50	=	2.5	nM	PMID[24171469]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Inhibition	=	98.0	%	PMID[24183585]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Inhibition	=	81.0	%	PMID[24183585]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	10.0	nM	PMID[25087049]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	5.2	nM	DOI[10.1039/C5MD00414D]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	1.45	nM	PMID[25129170]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	28.1	nM	PMID[25129170]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	29.3	nM	PMID[25129170]
NPT1167	Individual protein	Delta opioid receptor	Mus musculus	IC50	=	155.0	nM	PMID[25129170]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	EC50	=	120.0	nM	PMID[25783191]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Emax	=	106.0	%	PMID[25783191]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Activity	=	1.0	nM	PMID[25783191]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	22.0	nM	PMID[25494650]
NPT1075	Individual protein	Kappa opioid receptor	Cavia porcellus	Ki	=	35.0	nM	PMID[26411794]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	3.9	nM	PMID[26411794]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	IC50	=	6.3	nM	PMID[26789491]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	120.0	nM	PMID[26390077]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	0.53	nM	PMID[26390077]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	5.2	nM	PMID[28218838]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Ki	=	4.6	nM	PMID[28603600]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	340.0	nM	PMID[29649744]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Inhibition	=	80.0	%	PMID[29649744]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Inhibition	=	42.0	%	PMID[29649744]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Inhibition	=	63.0	%	PMID[29649744]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Inhibition	=	31.0	%	PMID[29649744]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Inhibition	=	85.0	%	PMID[29649744]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Inhibition	=	61.0	%	PMID[29649744]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	64.0	nM	PMID[30199635]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	83.0	%	PMID[30199635]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	deltalog(Tau/KA)	=	-0.3	n.a.	PMID[30199635]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	379.0	nM	PMID[30199635]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	24.0	%	PMID[30199635]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	deltalog(Tau/KA)	=	-0.6	n.a.	PMID[30199635]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	deltalog(Tau/KA)	=	0.25	n.a.	PMID[30199635]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ratio	=	1.8	n.a.	PMID[30199635]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Emax	=	209.0	%	PMID[31738550]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	36.8	nM	PMID[31986033]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	=	104.1	nM	PMID[31986033]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	4.2	nM	PMID[31986033]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	147.0	nM	PMID[31986033]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	EC50	>	593.0	nM	PMID[31986033]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Efficacy	=	98.5	%	PMID[31986033]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Efficacy	>	30.0	%	PMID[31986033]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	61.0	nM	PMID[30924650]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Efficacy	=	57.0	%	PMID[30924650]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	IC50	=	410.0	nM	PMID[31676224]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	6.08	nM	PMID[31472474]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	4.7	nM	PMID[33479684]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	103.0	%	PMID[33479684]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	379.6	nM	PMID[33479684]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	25.7	%	PMID[33479684]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ratio	=	2.3	n.a.	PMID[33479684]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	5.0	nM	PMID[27958743]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	EC50	=	330.0	nM	PMID[27958743]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	EC50	=	780.0	nM	PMID[27958743]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	380.0	nM	PMID[27958743]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	38.0	%	PMID[27958743]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Emax	=	100.0	%	PMID[27958743]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Emax	=	90.0	%	PMID[27958743]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ratio	=	0.36	n.a.	PMID[27958743]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	EC50	=	79.12	nM	PMID[33214823]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	203.97	nM	PMID[33214823]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	4.19	nM	PMID[33635670]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Activity	n.a.	n.a.	n.a.	PMID[34505767]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Emax	=	71.0	%	PMID[34505767]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Ki	=	6.9	nM	PMID[34387468]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	97.4	%	PMID[34011153]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	EC50	=	489.78	nM	PMID[37467430]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	8.71	nM	PMID[34011153]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	92.1	%	PMID[34011153]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	pEC50	n.a.	n.a.	n.a.	PMID[34465090]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	EC50	n.a.	n.a.	n.a.	PMID[34465090]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	EC50	n.a.	n.a.	n.a.	PMID[34465090]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	71.6	nM	PMID[34465090]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	70.79	nM	PMID[34465090]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Emax	=	64.4	%	PMID[37467430]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	EC50	=	12.1	nM	PMID[37467430]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	EC50	=	208.93	nM	PMID[37467430]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Emax	n.a.	n.a.	n.a.	PMID[34465090]
NPT1070	Individual protein	Sigma-1 receptor	Cavia porcellus	Activity	n.a.	n.a.	n.a.	PMID[38015878]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	EC50	=	491.0	nM	PMID[37467430]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	EC50	=	12.02	nM	PMID[37467430]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	416.87	nM	PMID[34011153]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Emax	=	100.2	%	PMID[37467430]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	=	76.9	nM	PMID[34387468]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	Ki	=	5.2	nM	PMID[35033825]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	79.43	nM	PMID[34011153]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	pEC50	n.a.	n.a.	n.a.	PMID[34465090]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	=	2.84	nM	PMID[34995453]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Emax	n.a.	n.a.	n.a.	PMID[34465090]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	32.0	%	PMID[34505767]
NPT1074	Individual protein	Mu opioid receptor	Cavia porcellus	IC50	=	150.0	nM	PMID[34995453]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	IC50	=	1215.0	nM	PMID[34995453]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	61.6	%	PMID[34465090]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	73.4	%	PMID[34011153]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	EC50	=	207.0	nM	PMID[37467430]
NPT1168	Individual protein	Mu opioid receptor	Mus musculus	Emax	=	71.9	%	PMID[37467430]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	EC50	=	21.0	nM	PMID[38015878]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	EC50	=	123.5	nM	PMID[34387468]
NPT1069	Individual protein	Mu opioid receptor	Rattus norvegicus	Emax	=	209.0	%	PMID[34387468]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Emax	=	69.0	%	PMID[34505767]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	Relative molar potency	=	1.0	n.a.	PMID[6284938]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	10.0	nM	PMID[6106064]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	250.0	nM	PMID[6106064]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	Ratio	=	25.0	n.a.	PMID[6106064]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	29.0	nM	PMID[3020245]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	65.0	nM	PMID[2872334]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	Relative potency	=	1.0	n.a.	PMID[2872334]
NPT3601	Individual protein	Kappa opioid receptor	Rattus norvegicus	Ki	=	113.0	nM	PMID[16033285]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	24.0	nM	PMID[6312042]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	IC50	=	28.0	nM	PMID[1310115]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	Control	=	86.0	%	PMID[6248645]
NPT4389	Protein family	Opioid receptors; mu/kappa/delta	Homo sapiens	Control	=	75.0	%	PMID[6248645]
NPT3601	Individual protein	Kappa opioid receptor	Rattus norvegicus	Ki	=	27.0	nM	DOI[10.1016/0960-894X(95)00077-7]
NPT613	Individual protein	Solute carrier family 22 member 1	Homo sapiens	IC50	=	28000.0	nM	PMID[18788725]
NPT613	Individual protein	Solute carrier family 22 member 1	Homo sapiens	Inhibition	=	67.9	%	PMID[18788725]
NPT702	Individual protein	UDP-glucuronosyltransferase 1-6	Homo sapiens	Activity	=	0.0	pm/min/mg	PMID[10836148]
NPT703	Individual protein	UDP-glucuronosyltransferase 1-9	Homo sapiens	Activity	=	0.0	pm/min/mg	PMID[10836148]
NPT695	Individual protein	UDP-glucuronosyltransferase 1-8	Homo sapiens	Activity	=	35.0	pm/min/mg	PMID[10836148]
NPT695	Individual protein	UDP-glucuronosyltransferase 1-8	Homo sapiens	Activity	=	15.0	pm/min/mg	PMID[10836148]
NPT701	Individual protein	UDP-glucuronosyltransferase 2B4	Homo sapiens	Activity	=	0.0	pm/min/mg	PMID[10836148]
NPT25401	Single protein	Opioid receptor homologue	Danio rerio	Ki	=	223.0	nM	PMID[28284867]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	IC50	>	135000.0	nM	PMID[20829430]
NPT613	Individual protein	Solute carrier family 22 member 1	Homo sapiens	FC	=	4.6	n.a.	PMID[31597043]
NPT613	Individual protein	Solute carrier family 22 member 1	Homo sapiens	FC	=	5.1	n.a.	PMID[31597043]
NPT613	Individual protein	Solute carrier family 22 member 1	Homo sapiens	FC	=	4.3	n.a.	PMID[31597043]
NPT613	Individual protein	Solute carrier family 22 member 1	Homo sapiens	IC50	=	71790.0	nM	PMID[31597043]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	IC50	=	684.0	nM	PMID[7739011]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	90.0	nM	PMID[12570383]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	IC50	=	7.37	nM	PMID[7739011]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	157.0	nM	PMID[14998329]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	280.0	nM	PMID[2828622]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	217.0	nM	PMID[15857143]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	684.0	nM	PMID[7739013]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	IC50	=	205.0	nM	PMID[1851843]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Activity	=	1220.0	nM	PMID[8390575]
NPT5342	Protein family	Opioid receptors; mu and delta	Mus musculus	ED50	=	0.4	mg.kg-1	PMID[12699394]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	15.0	nM	DOI[10.1016/0960-894X(95)00077-7]
NPT98	Individual protein	HERG	Homo sapiens	IC50	=	1000000.0	nM	PMID[15911273]
NPT5343	Individual protein	Nociceptin receptor	Cavia porcellus	Ki	=	13.9	nM	PMID[16777416]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	IC50	=	112200.0	nM	PMID[18370374]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	76.9	nM	PMID[19932964]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	IC50	=	404.0	nM	PMID[20413312]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	>	10000.0	nM	PMID[20580236]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	113.0	nM	PMID[21235243]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	1.8	nM	PMID[21481987]
NPT697	Individual protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	2536.0	pm/min/mg	PMID[10836148]
NPT697	Individual protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	2968.0	pm/min/mg	PMID[10836148]
NPT697	Individual protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	3719.0	pm/min/mg	PMID[10836148]
NPT697	Individual protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	0.0	pm/min/mg	PMID[10836148]
NPT697	Individual protein	UDP-glucuronosyltransferase 2B7	Homo sapiens	Activity	=	160.0	pm/min/mg	PMID[10836148]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	171.0	nM	PMID[23419026]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	82.5	nM	PMID[25129170]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	2.0	nM	PMID[26411794]
NPT3600	Individual protein	Delta opioid receptor	Rattus norvegicus	Ki	=	116.8	nM	PMID[34387468]
NPT2863	Protein family	Opioid receptor	Mus musculus	Relative molar potency	=	1.0	n.a.	PMID[6284938]
NPT2863	Protein family	Opioid receptor	Mus musculus	IC50	=	258.0	nM	PMID[10891118]
NPT3603	Individual protein	Kappa opioid receptor	Mus musculus	Ki	=	1549.49	nM	PMID[1967312]
NPT1774	Protein family	Sodium channel alpha subunits; brain (Types I, II, III)	Homo sapiens	Inhibition	=	5.3	%	PMID[2579237]
NPT3603	Individual protein	Kappa opioid receptor	Mus musculus	Potency ratio	=	0.13	n.a.	PMID[1659636]
NPT3603	Individual protein	Kappa opioid receptor	Mus musculus	Ki	=	301.0	nM	PMID[7932577]
NPT2863	Protein family	Opioid receptor	Mus musculus	Log AP	=	5.21	n.a.	PMID[2213833]
NPT2863	Protein family	Opioid receptor	Mus musculus	ED50	=	6.13	umol.kg-1	PMID[2213833]
NPT2863	Protein family	Opioid receptor	Mus musculus	ED50	=	0.85	mg.kg-1	PMID[12699394]
NPT2863	Protein family	Opioid receptor	Mus musculus	IC50	=	27.0	nM	PMID[6292420]
NPT3603	Individual protein	Kappa opioid receptor	Mus musculus	IC50	=	145.1	nM	PMID[18829333]
NPT66	Individual protein	Acetylcholinesterase	Electrophorus electricus	Ki	=	109000.0	nM	PMID[20580236]
NPT901	Individual protein	UDP-glucuronosyltransferase 1-1	Homo sapiens	Activity	=	0.0	pm/min/mg	PMID[10836148]
NPT902	Individual protein	UDP-glucuronosyltransferase 1A4	Homo sapiens	Activity	=	0.0	pm/min/mg	PMID[10836148]
NPT696	Individual protein	UDP-glucuronosyltransferase 2A1	Homo sapiens	Activity	=	73.0	pm/min/mg	PMID[10836148]
NPT700	Individual protein	UDP-glucuronosyltransferase 2B10	Homo sapiens	Activity	=	0.0	pm/min/mg	PMID[10836148]
NPT3603	Individual protein	Kappa opioid receptor	Mus musculus	Inhibition	=	71.0	%	PMID[23880538]
NPT3603	Individual protein	Kappa opioid receptor	Mus musculus	EC50	=	400.0	nM	PMID[23880538]
NPT3607	Individual protein	Delta-type opioid receptor	Cricetulus griseus	Inhibition	=	95.0	%	PMID[24183585]
NPT3607	Individual protein	Delta-type opioid receptor	Cricetulus griseus	Inhibition	=	72.0	%	PMID[24183585]
NPT5344	Individual protein	Mu opioid receptor-like OR2	Danio rerio	Ki	=	187.4	nM	PMID[26134550]
NPT5344	Individual protein	Mu opioid receptor-like OR2	Danio rerio	Ki	=	187.0	nM	PMID[28284867]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	Ki	=	32.5	nM	PMID[9572880]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	4.2	nM	PMID[6288945]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	27.0	nM	PMID[6288945]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	4.5	nM	PMID[6600791]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	73.0	nM	PMID[6600791]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	11.0	nM	PMID[6249930]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	22.0	nM	PMID[6259354]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	160.0	nM	PMID[2876106]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	8.6	nM	PMID[2999399]
NPT5130	Individual protein	Mu opioid receptor	Bos taurus	Ki	=	0.9	nM	PMID[8642554]
NPT5130	Individual protein	Mu opioid receptor	Bos taurus	Activity	=	67.0	n.a.	PMID[7515442]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	Inhibition	=	1.0	%	PMID[6315939]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	Inhibition	=	2.0	%	PMID[6315939]
NPT5130	Individual protein	Mu opioid receptor	Bos taurus	Ki	=	0.5	nM	PMID[1315868]
NPT5130	Individual protein	Mu opioid receptor	Bos taurus	Ki	=	2.5	nM	PMID[1315868]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	0.027	nM	PMID[2863378]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	3.7	nM/mg*min	PMID[12699389]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Inhibition	=	2.0	%	PMID[12699389]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	IC50	>	50000.0	nM	PMID[12699389]
NPT704	Individual protein	UDP-glucuronosyltransferase 2B15	Homo sapiens	Activity	=	0.0	pm/min/mg	PMID[10836148]
NPT699	Individual protein	UDP-glucuronosyltransferase 1-10	Homo sapiens	Activity	=	0.0	pm/min/mg	PMID[10836148]
NPT694	Individual protein	UDP-glucuronosyltransferase 1-3	Homo sapiens	Activity	=	21.0	pm/min/mg	PMID[10836148]
NPT668	Individual protein	P-glycoprotein 1	Homo sapiens	Activity	=	2.0	%	PMID[12699389]
NPT3606	Individual protein	Kappa-type opioid receptor	Cricetulus griseus	Inhibition	=	100.0	%	PMID[24183585]
NPT3606	Individual protein	Kappa-type opioid receptor	Cricetulus griseus	Inhibition	=	95.0	%	PMID[24183585]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	EC50	=	3.0	nM	PMID[73588]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	Activity	=	3.0	nM	PMID[16133]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	ED50	=	3.0	nM	PMID[199728]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	10.0	nM	PMID[207868]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	IC50	=	250.0	nM	PMID[207868]
NPT3590	Protein family	Opioid receptor	Rattus norvegicus	Ratio IC50	=	25.0	n.a.	PMID[207868]
NPT25402	Single protein	Opioid receptor, delta 1b	Danio rerio	Ki	=	1427.0	nM	PMID[28284867]

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT5131	Others	Opioid receptors; delta & kappa	Homo sapiens	Ratio	=	5.8	n.a.	PMID[15055988]
NPT1258	Others	Opioid receptors; mu & delta	Homo sapiens	Selectivity	=	156.0	n.a.	PMID[11000010]
NPT5131	Others	Opioid receptors; delta & kappa	Homo sapiens	Selectivity	=	6.0	n.a.	PMID[11000010]
NPT1258	Others	Opioid receptors; mu & delta	Homo sapiens	IC50	=	309.0	nM	PMID[2828622]
NPT1258	Others	Opioid receptors; mu & delta	Homo sapiens	Selectivity	=	5.55	n.a.	PMID[2828622]
NPT1258	Others	Opioid receptors; mu & delta	Homo sapiens	Ratio	=	46.0	n.a.	PMID[2887656]
NPT1258	Others	Opioid receptors; mu & delta	Homo sapiens	Ki ratio	=	0.11	n.a.	PMID[12166947]
NPT1258	Others	Opioid receptors; mu & delta	Homo sapiens	Selectivity	=	127.0	n.a.	PMID[15509180]
NPT5131	Others	Opioid receptors; delta & kappa	Homo sapiens	Ratio Ki	=	5.8	n.a.	PMID[16392810]
NPT4410	Others	Opioid receptor (mu and kappa)	Cavia porcellus	Ratio Ki	=	0.037	n.a.	PMID[19027293]
NPT4410	Others	Opioid receptor (mu and kappa)	Cavia porcellus	Ratio	=	0.25	n.a.	PMID[18829333]
NPT632	Tissue	Brain	Rattus norvegicus	Kin	=	1.6	10^-4ml/g/s	PMID[20210346]
NPT4410	Others	Opioid receptor (mu and kappa)	Cavia porcellus	Ratio Ki	=	27.4	n.a.	PMID[21641219]
NPT4410	Others	Opioid receptor (mu and kappa)	Cavia porcellus	Ratio Ki	=	0.02	n.a.	PMID[21641798]
NPT632	Tissue	Brain	Rattus norvegicus	Vdu	=	3.7	ml	PMID[19764786]
NPT4410	Others	Opioid receptor (mu and kappa)	Cavia porcellus	Ratio Ki	>	100.0	n.a.	PMID[23517479]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	20000.0	nM	DOI[10.6019/CHEMBL4651402]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	19952.62	nM	DOI[10.6019/CHEMBL4651402]
NPT28438	Unchecked	Unchecked	n.a.	Activity	n.a.	n.a.	n.a.	PMID[36084534]
NPT28438	Unchecked	Unchecked	n.a.	Ratio Ki	=	0.1	n.a.	PMID[34387468]
NPT28438	Unchecked	Unchecked	n.a.	Ratio Ki	=	1.5	n.a.	PMID[34387468]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Molar potency	=	6.5	n.a.	PMID[6284938]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Ratio	=	0.6	n.a.	PMID[3361582]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ED50	=	1.139	mg.kg-1	PMID[27933962]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	ED50	=	0.123	mg.kg-1	PMID[27933962]
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Ratio	=	0.04	n.a.	PMID[15055988]
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Selectivity	=	27.0	n.a.	PMID[11000010]
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Ratio	=	0.02	n.a.	PMID[2832603]
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Selectivity ratio	=	0.01	n.a.	PMID[1323679]
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Ratio	=	0.0056	n.a.	PMID[8390575]
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Selectivity	=	42.0	n.a.	PMID[15509180]
NPT4390	Others	Opioid receptors; mu & kappa	Homo sapiens	Ratio Ki	=	0.04	n.a.	PMID[16392810]
NPT2	Others	Unspecified	n.a.	IC50	=	54.7	nM	PMID[10891118]
NPT2	Others	Unspecified	n.a.	Ratio	=	38.0	n.a.	PMID[7932535]
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Ratio	=	2.84	n.a.	PMID[8642567]
NPT2	Others	Unspecified	n.a.	Ratio	=	0.396	n.a.	PMID[8642567]
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Ratio	=	0.02	n.a.	PMID[1851843]
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Ratio	=	0.07	n.a.	PMID[14998329]
NPT2	Others	Unspecified	n.a.	Ratio	=	1.2	n.a.	PMID[14998329]
NPT2	Others	Unspecified	n.a.	Ratio	=	11.0	n.a.	PMID[1433221]
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Ratio	=	130.0	n.a.	PMID[2828622]
NPT2	Others	Unspecified	n.a.	Ratio	=	8.5	n.a.	PMID[2999399]
NPT2	Others	Unspecified	n.a.	Ratio	=	500.0	n.a.	PMID[2999404]
NPT2	Others	Unspecified	n.a.	Ratio	=	4.0	n.a.	PMID[6312042]
NPT2	Others	Unspecified	n.a.	ED50	=	1.339	umol.kg-1	PMID[1323679]
NPT2	Others	Unspecified	n.a.	ED50	=	9.81	umol.kg-1	PMID[1323679]
NPT2	Others	Unspecified	n.a.	Ratio	=	15.0	n.a.	PMID[12408719]
NPT2	Others	Unspecified	n.a.	Ratio	=	0.18	n.a.	PMID[6276540]
NPT2	Others	Unspecified	n.a.	Ratio	=	12.5	n.a.	PMID[1714957]
NPT2	Others	Unspecified	n.a.	Ratio	=	17.3	n.a.	PMID[12699394]
NPT2	Others	Unspecified	n.a.	Ratio	=	33.1	n.a.	PMID[15664820]
NPT2	Others	Unspecified	n.a.	ED50	=	1.9	mg.kg-1	PMID[12699394]
NPT2762	Organism	Monkey	Cercopithecidae	ED50	=	1.2	mg.kg-1	PMID[1433169]
NPT2	Others	Unspecified	n.a.	Ki	=	6.55	nM	PMID[15664820]
NPT2	Others	Unspecified	n.a.	Ki	=	217.0	nM	PMID[21235243]
NPT2	Others	Unspecified	n.a.	Ki	=	90.0	nM	PMID[15482911]
NPT2	Others	Unspecified	n.a.	Ki	=	1100.0	nM	PMID[15509180]
NPT2	Others	Unspecified	n.a.	Ki	=	140000.0	nM	PMID[15509180]
NPT2	Others	Unspecified	n.a.	Ki	=	47000.0	nM	PMID[15509180]
NPT2	Others	Unspecified	n.a.	EC50	=	15.6	n.a.	PMID[15509180]
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Selectivity ratio	=	33.0	n.a.	PMID[16033285]
NPT3602	Others	Opioid receptors; mu & delta	Rattus norvegicus	Selectivity	=	33.0	n.a.	PMID[15857143]
NPT2	Others	Unspecified	n.a.	Ratio	=	5.1	n.a.	PMID[15857143]
NPT2	Others	Unspecified	n.a.	EC50	=	23.6	nM	PMID[17962026]
NPT2	Others	Unspecified	n.a.	EC50	=	142.0	nM	PMID[17962026]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	61.0	n.a.	PMID[18311899]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	38.0	n.a.	PMID[18311899]
NPT2	Others	Unspecified	n.a.	Ki	=	140.0	nM	PMID[21641798]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	6.0	n.a.	PMID[19027293]
NPT2	Others	Unspecified	n.a.	Ki	=	2.0	nM	PMID[14738380]
NPT2	Others	Unspecified	n.a.	Ratio	=	0.06	n.a.	PMID[18829333]
NPT2	Others	Unspecified	n.a.	Ratio	=	0.14	n.a.	PMID[18829333]
NPT2	Others	Unspecified	n.a.	Ratio IC50	=	71.6	n.a.	PMID[20413312]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	0.02	n.a.	PMID[21641798]
NPT25397	Protein complex	Mu opioid receptor/Alpha-2A adrenergic receptor	Homo sapiens	Activity	=	22.9	%	PMID[18193048]
NPT25397	Protein complex	Mu opioid receptor/Alpha-2A adrenergic receptor	Homo sapiens	Inhibition	=	25.0	%	PMID[18193048]
NPT25397	Protein complex	Mu opioid receptor/Alpha-2A adrenergic receptor	Homo sapiens	Activity	=	8.1	%	PMID[18193048]
NPT25397	Protein complex	Mu opioid receptor/Alpha-2A adrenergic receptor	Homo sapiens	EC50	=	3.0	nM	PMID[18193048]
NPT2	Others	Unspecified	n.a.	Ki	=	325.0	nM	PMID[21641219]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	164.0	n.a.	PMID[21641219]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	3.0	n.a.	PMID[21641798]
NPT2	Others	Unspecified	n.a.	Ki	=	900000.0	nM	PMID[15781124]
NPT2	Others	Unspecified	n.a.	Ki	=	3600000.0	nM	PMID[15781124]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_bilirubinemia	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_cholecystitis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_cholelithiasis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_cirrhosis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatic failure	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatic necrosis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatomegaly	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_jaundice	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_liver fatty	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_liver function tests abnormal	=	1.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_Combined Scores	=	1.0	n.a.	PMID[22194678]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	2107.0	n.a.	PMID[22680612]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	95.0	n.a.	PMID[22680612]
NPT20913	Tissue	Whole blood	Homo sapiens	Retention_time	=	1.67	min	DOI[10.1007/s00044-012-9977-1]
NPT2	Others	Unspecified	n.a.	Ratio Ki	>	100.0	n.a.	PMID[23517479]
NPT2	Others	Unspecified	n.a.	Ki	=	417.0	nM	PMID[23517479]
NPT2	Others	Unspecified	n.a.	Ratio EC50	=	10.0	n.a.	PMID[23880538]
NPT2	Others	Unspecified	n.a.	Ratio EC50	=	1.0	n.a.	PMID[23880538]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	57.0	n.a.	PMID[25129170]
NPT2	Others	Unspecified	n.a.	Ratio Ki	=	19.0	n.a.	PMID[25129170]
NPT2	Others	Unspecified	n.a.	Ki	=	2.6	nM	PMID[26134550]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_liver disease	=	0.0	n.a.	PMID[22194678]
NPT2	Others	Unspecified	n.a.	ID50	=	68.2	nM	PMID[73588]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.3	mg.kg-1	PMID[2170652]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.68	mg.kg-1	PMID[2170652]
NPT32	Organism	Mus musculus	Mus musculus	Duration	>	60.0	min	PMID[2170652]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.8	mg.kg-1	PMID[17962026]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.2	mg.kg-1	PMID[1311764]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.0	mg.kg-1	PMID[37335]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.9	mg.kg-1	PMID[9719602]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.811	umol.kg-1	PMID[12657261]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.319	umol.kg-1	PMID[12657261]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.339	umol.kg-1	PMID[1652025]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	9.81	umol.kg-1	PMID[1652025]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	32.58	umol.kg-1	PMID[1652025]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	492.0	nM	PMID[7205890]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.4	mg.kg-1	PMID[6600791]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.4	mg.kg-1	PMID[23010454]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	23.0	mg.kg-1	PMID[6600791]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	mg.kg-1	PMID[814236]
NPT32	Organism	Mus musculus	Mus musculus	AUEC	=	1030.0	A% min-1	PMID[12643945]
NPT32	Organism	Mus musculus	Mus musculus	AUEC	=	1987.0	A% min-1	PMID[12643945]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.9	umol.kg-1	PMID[7205892]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.72	umol.kg-1	PMID[7205892]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.68	mg.kg-1	PMID[691001]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.8	mg.kg-1	PMID[691001]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.98	mg.kg-1	PMID[17962026]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.85	mg.kg-1	PMID[1967312]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	244.0	nM	PMID[6207298]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.8	nM mouse-1	PMID[1846921]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.8	mg.kg-1	PMID[21291]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.23	mg.kg-1	PMID[21291]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.4	mg.kg-1	PMID[18311899]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.5	mg.kg-1	PMID[3361582]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.9	mg.kg-1	PMID[16033285]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3030.0	umol.kg-1	PMID[4009598]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.9	umol.kg-1	PMID[4009598]
NPT32	Organism	Mus musculus	Mus musculus	Relative potency	=	1.0	n.a.	PMID[2887656]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.5	mg.kg-1	PMID[2863378]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.42	mg.kg-1	PMID[7241506]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	500.0	nM	PMID[7241506]
NPT32	Organism	Mus musculus	Mus musculus	Relative potency	=	1.1	n.a.	PMID[7241506]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	17.9	mg.kg-1	PMID[9719602]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	100.0	%	PMID[27035422]
NPT32	Organism	Mus musculus	Mus musculus	A50	=	4.2	n.a.	PMID[14998329]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	12.42	umol.kg-1	PMID[6268787]
NPT32	Organism	Mus musculus	Mus musculus	Kd	>	1000.0	nM	PMID[6268787]
NPT32	Organism	Mus musculus	Mus musculus	EC50	=	19700.0	nM	PMID[12570383]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.1	umol.kg-1	PMID[22341895]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.3	mg.kg-1	PMID[9046345]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.7e-06	M kg-1	PMID[6312044]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	644.0	nM	PMID[1433221]
NPT32	Organism	Mus musculus	Mus musculus	Relative potency	=	0.02	n.a.	PMID[1433221]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	1420.0	nM	PMID[6310111]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.85	mg.kg-1	PMID[18311899]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.92	mg.kg-1	PMID[18311899]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.5	mg.kg-1	PMID[207868]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	28.9	mg.kg-1	PMID[10782691]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	15.0	mg.kg-1	PMID[18294843]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.0	umol.kg-1	PMID[2876106]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.3	n.a.	PMID[3023611]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	5.8	n.a.	PMID[3023611]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	0.23	n.a.	PMID[3023611]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.52	mg.kg-1	PMID[2999399]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	194.0	nM	PMID[6827557]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.79	mg.kg-1	PMID[6181259]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.8	mg.kg-1	PMID[1846921]
NPT32	Organism	Mus musculus	Mus musculus	MAD	=	2.0	mg kg-1	PMID[9513595]
NPT32	Organism	Mus musculus	Mus musculus	MNTD	=	20.0	mg kg-1	PMID[9513595]
NPT32	Organism	Mus musculus	Mus musculus	Analgesic efficacy compared to morphine	=	100.0	%	PMID[9513595]
NPT32	Organism	Mus musculus	Mus musculus	Analgesic efficacy compared to epibatidine	=	122.0	%	PMID[9513595]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.47	mg.kg-1	PMID[660593]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3090.0	pM mouse-1	PMID[2887656]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.8	umol.kg-1	PMID[2887656]
NPT32	Organism	Mus musculus	Mus musculus	Potency vs EKC	=	0.13	n.a.	PMID[1846918]
NPT32	Organism	Mus musculus	Mus musculus	Ke naloxone	=	4.2	nM	PMID[1846918]
NPT32	Organism	Mus musculus	Mus musculus	Antinociception	=	65.0	%	PMID[8642554]
NPT32	Organism	Mus musculus	Mus musculus	Antinociception	=	100.0	%	PMID[8642554]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.2	umol.kg-1	PMID[814236]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.6	umol.kg-1	PMID[12372519]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	14.4	umol.kg-1	PMID[1323679]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	21.6	uM	PMID[8960554]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.27	uM	PMID[8960554]
NPT32	Organism	Mus musculus	Mus musculus	Time of licking	=	41.0	s	PMID[9873678]
NPT32	Organism	Mus musculus	Mus musculus	Time of licking	=	0.0	s	PMID[9873678]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	14.6	n.a.	PMID[12620082]
NPT32	Organism	Mus musculus	Mus musculus	Licking latency	=	24.5	n.a.	PMID[12620082]
NPT32	Organism	Mus musculus	Mus musculus	Licking latency	=	28.7	n.a.	PMID[12620082]
NPT32	Organism	Mus musculus	Mus musculus	Licking latency	=	26.4	n.a.	PMID[12620082]
NPT32	Organism	Mus musculus	Mus musculus	Licking latency	=	23.8	n.a.	PMID[12620082]
NPT32	Organism	Mus musculus	Mus musculus	MAD	=	0.2	mg kg-1	PMID[12620082]
NPT32	Organism	Mus musculus	Mus musculus	MNTD	=	30.0	mg kg-1	PMID[12620082]
NPT32	Organism	Mus musculus	Mus musculus	Analgesic effect	=	100.0	%	PMID[12620082]
NPT32	Organism	Mus musculus	Mus musculus	Antagonism	=	0.0	%	PMID[12620082]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.2	mg.kg-1	PMID[9288177]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.6	ug	PMID[41949]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.3	mg.kg-1	PMID[12408719]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.7	mg.kg-1	PMID[12408719]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.46	mg.kg-1	PMID[6292420]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.06	mg.kg-1	PMID[6292420]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	31.2	mg.kg-1	PMID[2863378]
NPT32	Organism	Mus musculus	Mus musculus	Ki	=	1.0	nM	PMID[8390575]
NPT32	Organism	Mus musculus	Mus musculus	Ki	=	0.09	nM	PMID[8390575]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.99	mg.kg-1	PMID[8390575]
NPT32	Organism	Mus musculus	Mus musculus	Hind-paw lick latency time	=	25.2	s	PMID[6276540]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.2	nM	PMID[9288177]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.9	nM	PMID[4009598]
NPT32	Organism	Mus musculus	Mus musculus	ID50	=	1.7	mg.kg-1	DOI[10.1016/S0960-894X(01)80179-7]
NPT32	Organism	Mus musculus	Mus musculus	ID50	=	3.4	mg.kg-1	DOI[10.1016/S0960-894X(01)80179-7]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.34	umol.kg-1	PMID[7932577]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	9.8	umol.kg-1	PMID[17531479]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3030.0	pM mouse-1	PMID[4009598]
NPT32	Organism	Mus musculus	Mus musculus	IC50	=	1722.0	nM	PMID[1714957]
NPT32	Organism	Mus musculus	Mus musculus	Relative potency	=	0.0068	%	PMID[1714957]
NPT32	Organism	Mus musculus	Mus musculus	Analgesia	=	80.0	%	PMID[6248645]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.26	mg.kg-1	PMID[845878]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.36	mg.kg-1	PMID[6103962]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	8.1	mg.kg-1	PMID[6103962]
NPT32	Organism	Mus musculus	Mus musculus	ED50	>	25.0	mg.kg-1	PMID[6103962]
NPT32	Organism	Mus musculus	Mus musculus	ED50	>	20.0	mg.kg-1	PMID[6103962]
NPT32	Organism	Mus musculus	Mus musculus	MPE50	=	1.8	mg kg-1	PMID[6690685]
NPT32	Organism	Mus musculus	Mus musculus	MPE50	=	4.2	mg kg-1	PMID[6690685]
NPT32	Organism	Mus musculus	Mus musculus	MPE50	=	5.7	mg kg-1	PMID[6690685]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.6	mg.kg-1	DOI[10.1016/0960-894X(95)00077-7]
NPT32	Organism	Mus musculus	Mus musculus	Latency	=	28.6	s	PMID[15537361]
NPT32	Organism	Mus musculus	Mus musculus	Latency	=	27.7	s	PMID[15537361]
NPT32	Organism	Mus musculus	Mus musculus	Latency	=	22.4	s	PMID[15537361]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.622	umol.kg-1	PMID[15857143]
NPT32	Organism	Mus musculus	Mus musculus	Ratio	=	1.1	n.a.	PMID[15857143]
NPT32	Organism	Mus musculus	Mus musculus	AD50	=	6690.0	nmol/kg	PMID[15857143]
NPT32	Organism	Mus musculus	Mus musculus	A50	=	5.95	mg kg-1	PMID[17625813]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.56	mg.kg-1	PMID[17218099]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.73	mg.kg-1	PMID[17218099]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.1	mg.kg-1	PMID[423201]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	27.3	mg.kg-1	PMID[17531479]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	9.8	mg.kg-1	PMID[17531479]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	50.7	%	PMID[17587585]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.6	mg.kg-1	PMID[17962026]
NPT32	Organism	Mus musculus	Mus musculus	ID50	=	0.67	mg.kg-1	PMID[18160299]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	15.0	nM	PMID[18294843]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.95	nmol	PMID[17389363]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.085	nmol	PMID[17389363]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.36	umol.kg-1	PMID[17389363]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.7	nmol	PMID[17389363]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.088	nmol	PMID[17389363]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	6.47	umol.kg-1	PMID[17389363]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.59	mg.kg-1	PMID[19199782]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	0.008333	hr	PMID[19261477]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	0.007222	hr	PMID[19261477]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.58	mg.kg-1	PMID[18829333]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.26	mg.kg-1	PMID[18829333]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	18.4	umol.kg-1	PMID[10514316]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.4	umol.kg-1	PMID[10514316]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	92.9	%	PMID[18922604]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	87.45	%	PMID[18922604]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	6.9	mg.kg-1	PMID[19788200]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.5	mg.kg-1	PMID[21864951]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.1	ug	PMID[423201]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	1.5	umol/Kg	PMID[19800791]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	147.0	%	PMID[20176491]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	177.6	%	PMID[20176491]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	122.7	%	PMID[20176491]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	64.9	%	PMID[20176491]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	36.7	%	PMID[20176491]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	32.9	%	PMID[20176491]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	78.9	%	PMID[19327871]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	74.7	%	PMID[19327871]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	57.8	%	PMID[19327871]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	32.1	%	PMID[19327871]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	0.002694	hr	PMID[20598893]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	0.002861	hr	PMID[20598893]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	0.003556	hr	PMID[20598893]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	142.2	%	PMID[21474215]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	175.78	%	PMID[21474215]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	139.03	%	PMID[21474215]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	98.78	%	PMID[21474215]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	64.55	%	PMID[21474215]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	57.43	%	PMID[21474215]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.6	mg.kg-1	PMID[41949]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.4	mg.kg-1	PMID[21689868]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.44	mg.kg-1	PMID[21864951]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.1	mg.kg-1	PMID[22341895]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	9.15	mg.kg-1	PMID[22386241]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	13.5	mg.kg-1	PMID[22386241]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.57	mg.kg-1	PMID[22386241]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.96	mg.kg-1	PMID[22386241]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	6.6	umol.kg-1	PMID[23102273]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	66.0	%.min	PMID[23102273]
NPT32	Organism	Mus musculus	Mus musculus	A50	=	0.43	nmol	PMID[23016952]
NPT32	Organism	Mus musculus	Mus musculus	%max	=	100.0	%	PMID[23016952]
NPT32	Organism	Mus musculus	Mus musculus	A50	=	19.04	nmol	PMID[23016952]
NPT32	Organism	Mus musculus	Mus musculus	FC	=	44.0	n.a.	PMID[23016952]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	100.0	%	PMID[23517479]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.4	mg.kg-1	PMID[23010454]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	100.0	%	DOI[10.1007/s00044-012-0449-4]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	88.1	%	DOI[10.1007/s00044-011-9619-z]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	92.5	%	DOI[10.1007/s00044-011-9619-z]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	68.02	%	DOI[10.1007/s00044-012-0449-4]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	63.1	%	PMID[23523659]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	97.21	%	PMID[23734744]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	94.0	%	PMID[23734744]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	98.3	%	PMID[23734744]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.96	mg.kg-1	PMID[24103580]
NPT32	Organism	Mus musculus	Mus musculus	Retention_time	=	158.0	min	PMID[24063433]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	69.0	%	PMID[24063433]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.2	mg.kg-1	PMID[24360563]
NPT32	Organism	Mus musculus	Mus musculus	AD50	=	0.026	nmol	PMID[845862]
NPT32	Organism	Mus musculus	Mus musculus	AD50	=	0.031	nmol	PMID[845862]
NPT32	Organism	Mus musculus	Mus musculus	AD50	=	3.32	umol/Kg	PMID[845862]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	8.9	mg.kg-1	PMID[37335]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	70.0	%	PMID[853506]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	80.0	%	PMID[853506]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.5	umol.kg-1	PMID[207868]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.5	umol.kg-1	PMID[207868]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.51	mg.kg-1	PMID[24978316]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.8	mg.kg-1	PMID[24978316]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.24	mg.kg-1	PMID[25783191]
NPT32	Organism	Mus musculus	Mus musculus	Ratio ED50	=	9.6	n.a.	PMID[25559207]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	22.5	nmol	PMID[25559207]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.35	nmol	PMID[25996309]
NPT32	Organism	Mus musculus	Mus musculus	Ratio ED50	=	2.23	n.a.	PMID[25996309]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.91	mg.kg-1	PMID[25996309]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.07	mg.kg-1	PMID[25996309]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.35	nM	PMID[25996309]
NPT32	Organism	Mus musculus	Mus musculus	Ratio ED50	=	11.0	n.a.	PMID[26451468]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	301.0	pmol	PMID[26451468]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	27.0	pmol	PMID[26451468]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	15.0	pmol	PMID[18294843]
NPT32	Organism	Mus musculus	Mus musculus	Ratio ED50	=	8.0	n.a.	PMID[26451468]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	28.14	pmol	PMID[26451468]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	35.0	pmol	PMID[26451468]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.73	mg.kg-1	PMID[26524472]
NPT32	Organism	Mus musculus	Mus musculus	ID50	=	0.3431	mg.kg-1	PMID[26599832]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.0	nmol	PMID[27035422]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	7.46	nmol	PMID[27035422]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	36.5	%	PMID[27035422]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	30.15	%	PMID[27035422]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	63.8	%	PMID[27035422]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	50.0	%	PMID[27035422]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	159.7	%	PMID[28051863]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	185.0	%	PMID[28051863]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	98.6	%	PMID[28051863]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	124.5	%	PMID[28051863]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	86.7	%	PMID[28051863]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	94.6	%	PMID[28051863]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	12.6	%	PMID[28051863]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	24.3	%	PMID[28051863]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	30.0	%	PMID[28284867]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	51.0	%	PMID[28284867]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	45.0	%	PMID[28284867]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	6.7	mg.kg-1	PMID[27721146]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.428	mg.kg-1	PMID[29053268]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.38	mg.kg-1	PMID[29681486]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	6.5	umol.kg-1	PMID[29929882]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.53	ug	PMID[28603600]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	0.002083	hr	PMID[29421570]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	0.0009375	hr	PMID[29421570]
NPT32	Organism	Mus musculus	Mus musculus	Inhibition	=	86.0	%	PMID[29757638]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	6.95	mg.kg-1	PMID[31738550]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.84	mg.kg-1	PMID[31738550]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.44	nmol	PMID[30626554]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	6.67	%	PMID[30626554]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	9.88	%	PMID[30626554]
NPT32	Organism	Mus musculus	Mus musculus	Ratio ED50	=	6.0	n.a.	PMID[27556704]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	12.1	mg.kg-1	PMID[27556704]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.0	mg.kg-1	PMID[27556704]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	53.6	%	PMID[32199689]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.437	mg.kg-1	PMID[30571123]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	10.0	mg.kg-1	PMID[33120080]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.77	mg.kg-1	PMID[33170687]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.69	mg.kg-1	PMID[33170687]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.48	mg.kg-1	PMID[33170687]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.02	nmol	PMID[27798836]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	5.3	mg.kg-1	PMID[27958743]
NPT32	Organism	Mus musculus	Mus musculus	EC50	=	11.6	mg kg-1	PMID[27958743]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[33326237]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[34283606]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	11.3	umol.kg-1	PMID[34995453]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[37948340]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	17.3	nmol	PMID[34995453]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	77.2	umol.kg-1	PMID[34995453]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	1.75	hr	PMID[35255683]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[35271288]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[36084534]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	87.6	%	PMID[34465090]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.7	mg.kg-1	PMID[34783240]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	4.73	mg.kg-1	PMID[34783240]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.48	mg.kg-1	PMID[34783240]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	12.2	umol.kg-1	PMID[34995453]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	1.917	hr	PMID[35255683]
NPT32	Organism	Mus musculus	Mus musculus	TIME	=	2.067	hr	PMID[35255683]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	98.0	%	PMID[35850422]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	41.05	%	PMID[34781680]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[34781680]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	1.05	nmol	PMID[34995453]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.2	mg.kg-1	PMID[36084534]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.68	mg.kg-1	PMID[34783240]
NPT32	Organism	Mus musculus	Mus musculus	Activity	=	100.0	%	PMID[36966650]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[36793431]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[34465090]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.84	mg.kg-1	PMID[34387468]
NPT32	Organism	Mus musculus	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[34008968]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	3.3	mg.kg-1	PMID[34783240]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	8.7	nmol	PMID[34995453]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	0.72	pmol	PMID[34995453]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	2.48	mg.kg-1	PMID[34505767]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	75.3	%	PMID[34465090]
NPT32	Organism	Mus musculus	Mus musculus	MPE	=	63.0	%	PMID[34465090]
NPT32	Organism	Mus musculus	Mus musculus	ED50	=	6.95	mg.kg-1	PMID[34387468]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	68.2	nM	PMID[7205890]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	79.0	nM	PMID[7932535]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Kd	=	6.31	nM	PMID[9276018]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	79.8	nM	PMID[6207298]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Activity	=	8.2	n.a.	PMID[1361580]
NPT938	Organism	Cavia porcellus	Cavia porcellus	GPI	=	58.6	nM	PMID[3361582]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	0.13	nM	PMID[2754695]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Potency	=	1000000000.0	nM	PMID[6268787]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	69.7	nM	PMID[6268787]
NPT938	Organism	Cavia porcellus	Cavia porcellus	EC50	=	51.0	nM	PMID[12570383]
NPT938	Organism	Cavia porcellus	Cavia porcellus	pD2	=	7.17	n.a.	PMID[11960505]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Relative potency	=	100.0	%	PMID[11960505]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Inhibition	=	87.2	%	PMID[11960505]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Inhibition	=	100.0	%	PMID[11960505]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Contraction	=	27.4	%	PMID[11960505]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Relative potency	=	1.0	n.a.	PMID[4009598]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	75.0	nM	PMID[6312044]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	58.6	nM	PMID[4009598]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Relative potency	=	4.2	n.a.	PMID[1433221]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	292.0	nM	PMID[6310111]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	24.0	nM	PMID[6245210]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	2.92	nM	PMID[6090663]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	33.1	nM	PMID[6827557]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Ki	=	0.13	nM	PMID[8390575]
NPT938	Organism	Cavia porcellus	Cavia porcellus	pD2	=	7.23	M	DOI[10.1016/0960-894X(95)00239-P]
NPT938	Organism	Cavia porcellus	Cavia porcellus	IC50	=	140.0	nM	PMID[1714957]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Relative potency	=	0.22	%	PMID[1714957]
NPT938	Organism	Cavia porcellus	Cavia porcellus	Efficacy	=	66.0	%	PMID[15857121]
NPT938	Organism	Cavia porcellus	Cavia porcellus	EC50	=	127.4	nM	PMID[15857121]
NPT605	Organism	Homo sapiens	Homo sapiens	Activity	=	0.85	%	PMID[20022146]
NPT1016	Organism	Canis familiaris	Canis lupus familiaris	Activity	=	155.0	%	PMID[853506]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.11	mg.kg-1	PMID[2170652]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.77	mg.kg-1	PMID[2170652]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Duration	=	18.5	min	PMID[2170652]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Duration	=	102.2	min	PMID[2170652]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Duration	=	37.0	min	PMID[2170652]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Duration	=	115.3	min	PMID[2170652]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	A50	=	2.7	nM	PMID[10891118]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	A50	=	6.3	mM kg-1	PMID[10891118]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	A50	=	14.6	mM kg-1	PMID[10891118]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	A50	=	13.2	mM kg-1	PMID[10891118]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED2sec	=	0.7	mg kg-1	PMID[2831363]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.11	ug	PMID[10479285]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	10.0	mg.kg-1	PMID[853506]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.8	umol.kg-1	PMID[3669010]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Relative potency	=	1.0	n.a.	PMID[3669010]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.8	mg.kg-1	PMID[6259354]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	16.0	mg.kg-1	PMID[6259354]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MPE50	=	0.61	mg kg-1	PMID[2567782]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.4	ug	PMID[9651168]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.0056	mg.kg-1	PMID[1433221]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Effect	=	70.0	%	PMID[15012991]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	70.0	%	PMID[15012991]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MPE50	=	13.0	mg kg-1	PMID[2832603]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MPE50	=	1.4	mg kg-1	PMID[2832603]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	4.4	mg.kg-1	PMID[10782691]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	DOSE	=	5.2	mg.kg-1	PMID[10782691]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	23.0	nM	PMID[2876106]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	19.3	umol.kg-1	PMID[7192744]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	19.0	umol.kg-1	PMID[7310822]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	4.9	mg.kg-1	DOI[10.1016/S0960-894X(00)80398-4]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	54.0	mg.kg-1	DOI[10.1016/S0960-894X(00)80398-4]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MED50	=	3.2	mg kg-1	PMID[2878076]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Duration	=	90.0	min	PMID[2878076]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Duration	=	150.0	min	PMID[2878076]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Duration	=	240.0	min	PMID[2878076]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Duration	=	300.0	min	PMID[2878076]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Duration	=	380.0	min	PMID[2878076]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	IC50	=	200.0	nM	PMID[6313921]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Relative Potency	=	1.0	n.a.	PMID[6313921]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	10.6	n.a.	PMID[1671414]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.4	umol.kg-1	PMID[1671414]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.9	umol.kg-1	PMID[1671414]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.2	umol.kg-1	PMID[3981537]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Relative analgesic potency	=	1.0	n.a.	PMID[3981537]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.86	umol.kg-1	PMID[7932577]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	15.0	nM	PMID[12166947]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.67	umol.kg-1	PMID[6708052]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1.0	n.a.	PMID[6708052]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MPE50	=	4.8	mg kg-1	PMID[6690685]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MPE50	=	10.3	mg kg-1	PMID[6690685]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	40.0	%	PMID[19289283]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MPE	=	35.0	%	PMID[19351163]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	3.1	umol/Kg	PMID[19800791]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	577.0	%	PMID[19736007]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	38.0	%	PMID[20020710]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	77.0	%	PMID[20020710]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.7	mg.kg-1	PMID[26656913]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	6.053	umol.kg-1	PMID[21235243]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	7.626	umol.kg-1	PMID[21235243]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	13.29	umol.kg-1	PMID[21235243]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	FC	=	1.0	n.a.	PMID[21235243]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	TIME	=	0.3333	hr	PMID[21366266]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.3	mg.kg-1	PMID[21546249]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_elevated liver function tests	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatitis	=	0.0	n.a.	PMID[22194678]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.6	mg.kg-1	PMID[22386241]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.6	umol.kg-1	PMID[22680612]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	36.7	%	PMID[22680612]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	20.7	umol.kg-1	PMID[22680612]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	67.0	%	PMID[23043420]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	TIME	=	0.001472	hr	PMID[23043420]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Inhibition	=	70.0	%	PMID[23517479]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	<	40.0	mm	PMID[309950]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	>	34.0	mm	PMID[309950]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	>	50.0	mm	PMID[309950]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.26	mg.kg-1	PMID[73588]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.17	mg.kg-1	PMID[73588]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	3.9	mg.kg-1	PMID[41949]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	2.3	mg.kg-1	PMID[41949]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.5	mg.kg-1	PMID[13216]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	1.2	%	PMID[853506]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	4.43	mg.kg-1	PMID[1263200]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.57	mg.kg-1	PMID[817026]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	15.9	mg.kg-1	PMID[1263200]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AD50	=	29.0	mg kg-1	PMID[31481]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AD50	=	13.0	mg kg-1	PMID[31481]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Ratio	=	1.0	n.a.	PMID[1263200]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	5.34	mg.kg-1	PMID[21291]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	0.49	nmol	PMID[25544687]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	6.25	nmol	PMID[25544687]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	377.0	nmol	PMID[25544687]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	7.4	nmol	PMID[26348111]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Ratio	=	3.5	n.a.	PMID[26713106]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	=	52.0	%	PMID[28684121]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	5.1	mg.kg-1	PMID[31834797]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.49	mg.kg-1	PMID[33170687]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	3.6	mg.kg-1	PMID[33538583]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MPE	=	83.3	%	PMID[33538583]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	12.1	mg.kg-1	PMID[33635670]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	1.6	umol.kg-1	PMID[34995453]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	5.8	umol.kg-1	PMID[34995453]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Activity	n.a.	n.a.	n.a.	PMID[37690597]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ED50	=	169.3	umol.kg-1	PMID[34995453]

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference
Rattus norvegicus	Plasma	K(p,uu,CSF)	=	0.4	n.a.	PMID[19764786]
Rattus norvegicus	Plasma	Fu	=	0.9	n.a.	PMID[19764786]
Homo sapiens	Plasma	logFu	=	0.61	n.a.	PMID[19586686]
Homo sapiens	Zone of skin	log Kp	=	-8.57	n.a.	PMID[17827020]
Homo sapiens	Plasma	K(p,uu,CSF)	=	0.51	n.a.	PMID[19764786]
Rattus norvegicus	Brain	Fu	=	0.76	n.a.	PMID[21149540]
Rattus norvegicus	Brain	Vd	=	3.7	L.kg-1	PMID[21149540]
Rattus norvegicus	Plasma	Kp	=	2.81	n.a.	PMID[21149540]
Homo sapiens	n.a.	Fu	=	0.65	n.a.	PMID[18426954]

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference
-	Rattus norvegicus	LD50	=	530.0	mg.kg-1	PMID[6259354]
-	Mus musculus	LD50	=	531.0	mg.kg-1	PMID[7241506]

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC232533 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	15180
0.1-0.2	33385
0.2-0.3	1257
0.3-0.4	19
0.4-0.5	10
0.5-0.6	0
0.6-0.7	3
0.7-0.8	0
0.8-0.85	1
0.85-0.9	0
0.9-0.95	0
0.95-1	2

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC607466
0.9833	High Similarity	NPC485664
0.806	Intermediate Similarity	NPC243483
0.6857	Remote Similarity	NPC43069
0.6812	Remote Similarity	NPC97086
0.6667	Remote Similarity	NPC140577

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC232533 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	3393
0.1-0.2	5585
0.2-0.3	115
0.3-0.4	31
0.4-0.5	12
0.5-0.6	4
0.6-0.7	6
0.7-0.8	0
0.8-0.85	1
0.85-0.9	0
0.9-0.95	1
0.95-1	2

Similarity Score	Similarity Level	Drug ID	Developmental Stage
1.0	High Similarity	NPD2491	Phase 4
0.9833	High Similarity	NPD2489	Approved
0.9219	High Similarity	NPD27	Approved
0.806	Intermediate Similarity	NPD3448	Phase 2
0.6857	Remote Similarity	NPD2972	Phase 4
0.6667	Remote Similarity	NPD3533	Pre-clinical
0.6575	Remote Similarity	NPD2970	Approved
0.64	Remote Similarity	NPD2969	Approved
0.602	Remote Similarity	NPD3922	Phase 4
0.6	Remote Similarity	NPD5676	Phase 4
0.596	Remote Similarity	NPD3921	Approved
0.589	Remote Similarity	NPD2490	Phase 4
0.5862	Remote Similarity	NPD5619	Phase 2
0.5811	Remote Similarity	NPD2488	Approved

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data