TCM Prescription: Zhui Feng Ointment



Prescription Description
Prescription IDTCMF6607
Pinyin NameZhui Feng Gao
Chinese Name追风膏
English NameZhui Feng Ointment
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病,未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationBlood, SkeletaMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH670 Ligusticum sinense 藁本 TCMH670 ITSAP3226-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH296 Radix aconiti 川乌 TCMH296
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2267 Periploca sepium 香加皮 TCMH2267 ITSAJ4400-14, GBVP4570-15
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH672 Alpinia officinarum 高良姜 TCMH672 ITSAK2176-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2295 fructus foeniculi 小茴香 TCMH2295
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1282 Colletotrichum orbiculare
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, KIT, MET, MIF, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TRPV1, XDH 20.6833
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RORC, SMAD3, SRC, TEK, TOP1, TRPV1, TYR 16.5329
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 15.4975
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PRKCB, PRKCD, PRKCE, PTGES, PTGS2, RORC, SRC, TEK, TRPV1, TYR 15.4975
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.0737
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.0737
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 13.5587
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 13.5122
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 13.5044
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, TYR 12.6695
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.8008
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.7589
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, NR3C1, PRKCE, PRKCG, PTGES, PTGS2, RORC, SRC, TEK, TRPV1, TYR 11.7363
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.4854
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 11.468
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.2817
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.0587
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GRM5, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, KIT, MMP2, NR3C1, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 11.0164
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TRPV1 11.0073
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, KIT, NR3C1, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK, TRPV1 10.9971
[BP] GO:0007187 None ADORA1, CHRM2, CNR1, CNR2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 10.996
[BP] GO:0042493 response to drug ABCG2, AKR1B1, APEX1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, NR3C1, POLB, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TOP1, TRPV1 10.8378
[BP] GO:0007193 None ADORA1, CHRM2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 10.8378
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 10.6169
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 10.5663
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3802
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 10.3387
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, PRKCA, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 10.2253
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, NR3C1, PRKCE, PTGES, PTGS2, RORC, SRC, TYR 10.2156
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.1276
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.0248
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, KIT, PRKCE, PTGS2 9.95127
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, KIT, PRKCE, PTGS2 9.95127
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.73342
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, POLA1, POLB, PRKCB, PRKCE, SMAD3, SRC, TRPV1 9.71823
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.68546
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS1, PTGS2, TBXAS1 9.66589
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.65611
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 9.57796
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS1, PTGS2, TBXAS1 9.55375
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 9.42016
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS1, PTGS2, TBXAS1 9.33544
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 9.3157
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TOP1, TRPV1, TYR 9.26553
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 9.2601
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.22287
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.22287
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 9.22287
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, EGFR, GRM1, GRM3, GRM5, GRM8, HTR1B, HTR2A, PTGS2 9.20593
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GLO1, HSPA1A, HTR2B, HTR2C, MIF, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.06344
[BP] GO:0099536 None CHRM2, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, SLC1A1 9.06344
[BP] GO:0099537 None CHRM2, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, SLC1A1 9.06344
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, EGFR, FLT3, GRM1, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 9.0029
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PRKCD, SRC, TEK 8.99492
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.85631
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 8.73221
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 8.55838
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 8.55452
[BP] GO:0007188 None ADORA1, CHRM2, CNR1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 8.55452
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A, TRPV1 8.34686
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.32089
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 8.25782
[BP] GO:0007268 None CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, SLC1A1 8.23326
[BP] GO:0098916 None CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, SLC1A1 8.23326
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, PRKCA, PRKCE, SLC22A1 8.18284
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TRPV1 8.13224
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PRKCD, PTGES, PTGS2, SRC 8.01081
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 8.00068
[BP] GO:0007154 None ADORA1, AR, AXL, BCL2, CHRM2, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR, PRKCG, PTGS2, SLC1A1, TEK, TRPV1 7.85562
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 7.83006
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.79248
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK 7.70556
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.63746
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 7.57246
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 7.50398
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, EGFR, FABP3, FLT3, GRM5, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 7.50169
[BP] GO:0007267 None ADORA1, AR, CHRM2, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR, PRKCG, SLC1A1, TEK 7.47718
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS1, PTGS2, TBXAS1 7.46717
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.4021
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.39648
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 7.39575
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, KIT, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1, TYR 7.34445
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.25383
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 7.24555
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.22924
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS1, PTGS2, TBXAS1 7.05578
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM2, CNR1, CNR2, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC 7.05578
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PRKCD, SRC, TEK 7.05578
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.01536
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, EGFR, HCAR2, HTR2A, HTR2B, HTR2C, KDR, MIF, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 7.01536
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 7.01084
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 6.98885
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, HTR1D, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.98004
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, EGFR, FABP3, FLT3, GRM5, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 6.927
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 6.927
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.91296
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, PRKCE 6.91284
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.81656
[BP] GO:0023052 None ADORA1, AR, CHRM2, CNR1, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PGR, PRKCG, SLC1A1, TEK 6.71916
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.69205
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.65668
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, HTR7, KIT, PGR, PPARA, PRKCG, RORC, SRC, TOP1, TOP2A 6.52874
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 6.49419
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 6.48969
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PIK3CB, PRKCD, PTPN1, SRC 6.47251
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.44241
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TRPV1 6.44125
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 6.44125
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, PRKCG, SRC, TEK 6.42062
[BP] GO:0003018 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 6.42062
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, POLB, PRKCD, PRKCE, SRC 6.40258
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, KIT, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 6.36633
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 6.3332
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.31844
[BP] GO:0050801 ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 6.31119
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.30272
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.29775
[BP] GO:0007610 None APP, BCL2, CNR1, EGFR, GRM1, GRM5, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KIT, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 6.2371
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 6.20394
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, EGFR, ESR1, FLT3, GRM5, HTR1B, IGF1R, INSR, KIT, MMP2, NR3C1, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 6.17267
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.09934
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.08454
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.90156
[BP] GO:0019725 cellular homeostasis ABCG2, APEX1, APP, BCL2, CA2, CA7, ESR1, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, POLA1, PRKCB, PRKCE, SMAD3, TRPV1 5.89205
[BP] GO:0098771 inorganic ion homeostasis ABCG2, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.86525
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.86226
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCA, PTPN1, SRC, TEK 5.82841
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.78077
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 5.77833
[BP] GO:0055082 cellular chemical homeostasis ABCG2, APP, BCL2, CA2, CA7, ESR1, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.76701
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, KIT, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 5.76445
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, KIT, MET, MIF, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TYR 5.76126
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.71655
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, HTR2A, KIT, MIF, PRKCD, PRKCE, PTPN1, SRC 5.70723
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, HTR1B, KDR, NR3C1, PRKCD, PRKCE, PTGS2, SRC, TRPV1 5.70185
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 5.68013
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 5.66208
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.65482
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 5.61522
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.61077
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP2, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 5.60049
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.58876
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.55905
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SLC1A1, SMAD3, SRC, TEK, TRPV1 5.53311
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 5.5281
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CNR1, CSNK2A1, EGFR, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 5.5048
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC, TRPV1 5.50156
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 5.45945
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.4584
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCA, SRC, TEK 5.45656
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 5.43141
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.42366
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.41912
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.41269
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 5.40257
[BP] GO:0055080 cation homeostasis ABCG2, APP, BCL2, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.33384
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, EGFR, GRM1, GRM5, GRM8, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, KIT, PIK3CA, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 5.30461
[BP] GO:0003013 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 5.30461
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, HTR1A, INSR, PTGS2, SLC1A1, SLC22A2, SLC22A3, SMAD3, TRPV1 5.29928
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, HTR2C, PPARA, PRKCB, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 5.25229
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 5.25229
[BP] GO:0030003 cellular cation homeostasis ABCG2, APP, BCL2, CA2, CA7, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.25229
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, PRKCE, SRC, TRPV1 5.25229
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 5.24583
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.23933
[BP] GO:0097746 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.20025
[BP] GO:0035296 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.20025
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 5.19634
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A 5.19182
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CB, PTPN1, SRC 5.16028
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.12379
[BP] GO:0006873 cellular ion homeostasis ABCG2, APP, BCL2, CA2, CA7, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.12022
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.1125
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 5.09258
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, GRM3, GRM8, HCAR2, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 5.09258
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 5.08645
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 5.05881
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 5.05532
[BP] GO:0050880 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.99034
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 4.97898
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.97898
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.97314
[BP] GO:0006855 None ABCG2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.97314
[BP] GO:0035150 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.97314
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.91906
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.89519
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CHRM2, CNR1, CYP1B1, EGFR, ESR1, F3, GPR35, GRM1, HCAR2, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 4.89333
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 4.89225
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, PIK3CA, POLB, PPARA, SMAD3, SRC, TEK, TYR 4.85784
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.85784
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 4.85784
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.85056
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 4.84409
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.82269
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.78931
[BP] GO:0055065 metal ion homeostasis ABCG2, APP, BCL2, EGFR, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.78913
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, GPR35, HTR1B, HTR2A, MMP9, PRKCE, PTGS2 4.78183
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 4.75397
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 4.71384
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A, TYR 4.71384
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.71384
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, MIF, PRKCE, SRC, TRPV1 4.71384
[BP] GO:0006875 cellular metal ion homeostasis ABCG2, APP, BCL2, ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.69487
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 4.69348
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.65728
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.6028
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 4.60165
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 4.5611
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, KIT, MET, MIF, NUAK1, PIK3CA, PIK3CB, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 4.5611
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PIK3CB, PRKCD, PTPN1, SRC 4.50647
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, KIT, MIF, PIK3CA, PIK3CB, POLB, PTGES, PTGS1, PTGS2, TRPV1 4.50206
[BP] GO:0019371 None PTGES, PTGS1, PTGS2, TBXAS1 4.48404
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, NR3C1, PTGS2, SRC 4.46179
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, EGFR, GRIK5, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCE, SRC, TRPV1 4.45243
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 4.43295
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGES, PTGS2 4.36462
[BP] GO:0044057 None ADORA1, ADORA3, CHRM2, EGFR, GPR35, GRM1, HCAR2, HTR2A, HTR2C, KIT, PRKCA, PTGS2, SLC1A1, SMAD3, TRPV1 4.34575
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, HTR2B, MET, PIK3CA, PPARA, PRKCG, SMAD3 4.33551
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 4.29656
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 4.29579
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 4.27551
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA, PRKCD, PRKCE 4.26471
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1 4.25172
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, EGFR, GRIK5, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCE, SRC 4.23284
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGES, PTGS1, PTGS2 4.22023
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, GRM5, HTR1B, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 4.21062
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.21062
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CNR1, GPR35, GRM5, HTR1A, HTR1B, HTR2A, MIF, MMP9, PRKCD, PRKCE, PTGS2 4.20632
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.19014
[BP] GO:0001516 None MIF, PTGES, PTGS1, PTGS2 4.18622
[BP] GO:0046457 None MIF, PTGES, PTGS1, PTGS2 4.18622
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 4.17956
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 4.16418
[BP] GO:0042391 None ADORA1, APP, BCL2, CNR1, CNR2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 4.16183
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.08817
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.08401
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.08401
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, HCAR2, HSPA1A, KIT, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 4.05894
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.0567
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 4.05589
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 4.05589
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 4.05082
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, MIF, POLB, PRKCD, PTGS2 3.99583
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, KIT, MIF, PIK3CB, PTPN1, SRC 3.98174
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.96571
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 3.91075
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1 3.90356
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.89914
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CNR1, EGFR, HCAR2, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.88577
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, GRM5, HTR1B, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 3.87085
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 3.84078
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 3.84078
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 3.83291
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.79143
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 3.79115
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 3.79115
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, BCL2, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.78364
[BP] GO:0090066 None ADORA1, ALOX15, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PRKCD, PRKCE, PTGS2 3.78364
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, PRKCA, PRKCE, SRC 3.76074
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.73683
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.73423
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.71559
[BP] GO:0015893 None ABCG2, CA2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.67088
[BP] GO:0008217 None ADORA1, AR, CNR1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 3.65038
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.58685
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PRKCD, PTGS2, SMAD3, TEK 3.57514
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.57514
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.57514
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.57021
[BP] GO:1900543 None GRM3, GRM8, HTR1B, HTR1E, PPARA, PRKCA 3.54816
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.54537
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HTR1A, HTR2A, HTR2C, PRKCA, PRKCE 3.54349
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.53553
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.53553
[BP] GO:0045980 None GRM3, GRM8, HTR1B, HTR1E, PPARA, PRKCA 3.51995
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AR, AURKB, BCL2, CNR1, CSNK2A1, DUSP3, ESR1, FABP4, GRM3, GRM8, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 3.51367
[BP] GO:0050678 None AR, EGFR, F3, HTR2B, KDR, MMP12, PGR, PRKCA, SMAD3, TEK, XDH 3.4881
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, HTR2B, INSR, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 3.4881
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.48387
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.43765
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1, RORC 3.43765
[BP] GO:0050890 None ADORA1, APP, CNR1, EGFR, GRM5, HTR2A, INSR, KIT, PRKCG, PTGS2 3.42806
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PRKCD, SMAD3, TEK 3.41495
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 3.39353
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK 3.37363
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.36283
[BP] GO:0008150 biological_process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 3.35822
[BP] GO:0040016 embryonic cleavage PIK3CB, TOP1, TOP2A 3.35822
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.35822
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.35822
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.35822
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 3.35797
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.35797
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.35797
[BP] GO:0032870 cellular response to hormone stimulus APEX1, AR, EGFR, ESR1, FLT3, INSR, KIT, NR3C1, PRKCD, PRKCE, SRC 3.35236
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, MIF, PRKCA, PTGS2, SMAD3 3.35011
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 3.33039
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.31292
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.30597
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PRKCE, PTGS2 3.29149
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 3.28613
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ESR1, GPR35, GRM1, GRM5, HTR2A, HTR2B, HTR2C, PRKCE, SMAD3, TRPV1 3.27623
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.27367
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PRKCD, SMAD3, TEK 3.2631
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, PRKCE, SRC 3.25938
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 3.24203
[BP] GO:0030815 None GRM3, GRM8, HTR1B, HTR1E, PRKCA 3.23569
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7, TRPV1 3.23569
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.23569
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF, PRKCD 3.23523
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, KIT, MIF, PTPN1, SRC 3.23516
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 3.21499
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.20972
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, MMP12, PRKCA, TEK 3.20644
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, PRKCB, PTGS2, TEK 3.20644
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, NR3C1, PGR, PIM1, PPARA, RORC, SRC 3.20644
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.20437
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.17711
[BP] GO:0032098 None HTR2C, HTR4, PPARA, SLC22A3 3.17711
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.1677
[BP] GO:0030800 None GRM3, GRM8, HTR1B, HTR1E, PRKCA 3.16607
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, PRKCE, SRC 3.1633
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 3.1633
[BP] GO:0007611 None APP, CNR1, EGFR, GRM5, HTR2A, INSR, KIT, PRKCG, PTGS2 3.15303
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.14789
[BP] GO:0051234 None ABCG2, ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1, XDH 3.1187
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, KIT, MIF, PIK3CA, PIK3CB, POLB, PRKCD, PTGES, PTGS1, PTGS2, SRC, TRPV1 3.1187
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.11405
[BP] GO:0007200 None CHRM2, ESR1, GRM5, HTR2A, HTR2B, HTR2C 3.11277
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.0984
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 3.09426
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.09313
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, KIT, PGR, PTGS2, SRC 3.07396
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.06219
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.06219
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.05281
[BP] GO:0006693 None MIF, PTGES, PTGS1, PTGS2 3.05281
[BP] GO:0006692 None MIF, PTGES, PTGS1, PTGS2 3.05281
[BP] GO:0006810 None ABCG2, ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1, XDH 3.01942
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.01231
[BP] GO:0002791 None ACHE, ADORA1, CNR1, EGFR, HCAR2, HTR2B, HTR2C, MIF, MMP12, PRKCA, PRKCE, SRC 3.00777
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, HSD11B2, HSD17B2, INSR, KIT, MMP2, MMP9, PGR, PTGS2, SRC, TOP2A 3.00032
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.9855
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.98497
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC, TRPV1 2.98177
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, GRM1, INSR, KIT, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.97094
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1, PTGS2 2.96036
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, MIF, PIK3CB 2.93638
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 2.93638
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.92073
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 2.92073
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.90864
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.90864
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 2.90864
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 2.90864
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGES, PTGS2, SRC 2.88747
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HTR5A, INSR, KDR, KIT, MMP9, PGR, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 2.88084
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA 2.87407
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 2.85702
[BP] GO:0009410 None CNR1, CNR2, EGFR, HTR1B, NR3C1, PRKCE, PRKCG 2.83844
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 2.83218
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 2.83029
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.83029
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.80433
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 2.79389
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.79389
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.79362
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.79362
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.79362
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 2.79362
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.79362
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.79362
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 2.7828
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.7828
[BP] GO:0009266 None ADORA1, HSPA1A, HTR1B, HTR2A, HTR2B, PTGS2, TRPV1 2.7828
[BP] GO:0007208 None HTR2A, HTR2C 2.7828
[BP] GO:0035408 None PRKCA, PRKCB 2.7828
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.7828
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 2.77976
[BP] GO:0070201 None ACHE, APP, BCL2, CNR1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.76403
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.76258
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 2.75459
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, PRKCD, SRC 2.75459
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC 2.75459
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK 2.72421
[BP] GO:0060402 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.7225
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.7225
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 2.71538
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DUSP3, ESR1, HSPA1A, KIT, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.70484
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.70112
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.70112
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.70112
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 2.70112
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TOP2A 2.69951
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CNR1, CSNK2A1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.69076
[BP] GO:0051179 None ABCG2, ACHE, ADORA1, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, EGFR, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1, XDH 2.68887
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, CNR1, GPR35, HSPA1A, HTR1B, HTR2A, MMP9, PRKCB, PRKCE, PTGS2 2.68533
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 2.68405
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 2.67328
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 2.67238
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC 2.64024
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.63461
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.63336
[BP] GO:0045913 None HTR2A, INSR, PPARA, PRKCE, SRC 2.6182
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.61095
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.60777
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.60777
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 2.60736
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.5926
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TRPV1, TYR 2.57893
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2C, INSR, KDR, KIT, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK 2.54239
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, HCAR2, PIK3CB, PTGS2 2.5352
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TEK, TYR 2.53433
[BP] GO:0051172 None APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, GRM3, GRM8, HSPA1A, HTR1B, HTR1E, IGF1R, MIF, MMP12, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.5142
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.5142
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.5142
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TOP2A 2.5142
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.5119
[BP] GO:0051223 None ACHE, APP, CNR1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.49883
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 2.48915
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.48868
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PTGS2, SRC, TEK 2.48097
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, PIK3CA, TRPV1 2.48021
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.46432
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 2.46291
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.4501
[BP] GO:1900542 None GRM3, GRM8, HTR1B, HTR1E, HTR2A, INSR, PPARA, PRKCA 2.44596
[BP] GO:0050714 None ACHE, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC 2.43497
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.43497
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.43497
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.43497
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, KIT, MMP12, PRKCD, PTGES, PTGS2, SMAD3, SRC, TRPV1, TYR 2.41787
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, PGR, SRC 2.41701
[BP] GO:0060401 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.41701
[BP] GO:0050877 None ADORA1, APP, CNR1, CNR2, CYP1B1, EGFR, GRM1, GRM5, GRM8, HTR2A, INSR, KIT, PRKCG, PTGS2, TRPV1, TYR 2.41547
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MIF, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC 2.38397
[BP] GO:0099566 None GRM1, GRM5 2.38397
[BP] GO:0060748 None AR, PGR 2.38397
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.38397
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38397
[BP] GO:0006140 None GRM3, GRM8, HTR1B, HTR1E, HTR2A, INSR, PPARA, PRKCA 2.37704
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.37704
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, NR3C1, PGR, SRC 2.37704
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.36664
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.36664
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.36664
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.36664
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.35287
[BP] GO:0002684 positive regulation of immune system process APP, AXL, BCL2, CA2, CNR1, HCAR2, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, SRC 2.33503
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.33397
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, EGFR, ESR1, KIT, PGR, PTGS2, SRC 2.32199
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 2.31824
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.31111
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ESR1, GPR35, GRM1, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.30056
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.29092
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC 2.28807
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, TEK, TRPV1, TYR 2.28807
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 2.28807
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.28807
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.28807
[BP] GO:0030818 None GRM3, GRM8, HTR1B, PRKCA 2.27982
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.27982
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, KIT, PRKCB, PRKCD, RORC, SMAD3 2.27792
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 2.27333
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PRKCD, PTGS2 2.26681
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, XDH 2.24448
[BP] GO:0001936 None F3, HTR2B, KDR, PRKCA, TEK, XDH 2.2395
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, F10, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.23437
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.22458
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.22304
[BP] GO:0060191 regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 2.22304
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.22304
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.22133
[BP] GO:0030803 None GRM3, GRM8, HTR1B, PRKCA 2.21258
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3, TRPV1 2.20622
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.20541
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, PTGS2, TRPV1, TYR 2.20541
[BP] GO:0006633 None ALOX15, MIF, PTGES, PTGS1, PTGS2 2.2041
[BP] GO:0001938 None F3, HTR2B, KDR, PRKCA, TEK 2.2041
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, POLA1, POLB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TOP2A, TRPV1 2.20131
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TRPV1, TYR 2.20003
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, PRKCB, PTGS2, TEK, XDH 2.18176
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.17114
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.16462
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.16462
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.1641
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.1641
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NR3C1, NUAK1, PIK3CA, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 2.13713
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A, TYR 2.13299
[BP] GO:0015874 None SLC22A1, SLC22A2 2.13133
[BP] GO:1901374 None SLC22A1, SLC22A2 2.13133
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.13133
[BP] GO:0038171 None CNR1, CNR2 2.13133
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.13133
[BP] GO:0014827 None HTR1D, HTR2B 2.13133
[BP] GO:1900372 None GRM3, GRM8, HTR1B, PRKCA 2.12749
[BP] GO:0030809 None GRM3, GRM8, HTR1B, PRKCA 2.12749
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.12749
[BP] GO:0043279 None CNR1, HTR1B, PRKCE, PRKCG, TRPV1 2.10908
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PRKCD, PRKCE, PTGS2, SRC 2.10908
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC 2.08636
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC 2.06852
[BP] GO:0045936 None DUSP3, FABP4, GRM3, GRM8, HTR1B, HTR1E, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 2.06489
[BP] GO:0050708 None ACHE, CNR1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCA, PRKCE, SRC 2.06234
[BP] GO:0010563 None DUSP3, FABP4, GRM3, GRM8, HTR1B, HTR1E, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 2.05957
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.05834
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTGS2, TEK, TRPV1, TYR 2.05364
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.05205
[BP] GO:0015844 None SLC22A1, SLC22A2, SLC22A3 2.05205
[BP] GO:0010676 None INSR, PPARA, PRKCE, SRC 2.03649
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.03649
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 2.03206
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX15, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.0258
[BP] GO:0019233 None CNR1, CNR2, GRM1, PTGS2 2.00642
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, MIF, PPARA, PRKCD, SMAD3, TEK 2.00398
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.00398
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, EGFR, ESR1, GRIK5, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.00186
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TRPV1 13.4769
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM2, CNR1, CNR2, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 11.5065
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SRC, TEK, TRPV1 10.996
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR 10.881
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM2, CNR1, CNR2, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 10.017
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR3C2, PIK3CA, PIK3CB, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TBXAS1, TEK, TRPV1, TYR 8.80986
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, CA2, CA4, CA9, CHRM2, CNR1, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, INSR, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SRC, TEK, TRPV1 6.90361
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, PRKCG, PTGS2, SRC 4.01454
[CC] GO:0097060 None CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, TRPV1 4.01071
[CC] GO:0031224 None ABCG2, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM2, CNR1, CNR2, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTGES, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TBXAS1, TEK, TRPV1, TYR 3.95611
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 3.86375
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, INSR, PRKCG, PTGS1, PTGS2, SLC22A2, SRC, TOP1, TRPV1 3.71559
[CC] GO:0043235 receptor complex ABCG2, APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, NR3C2, SMAD3 3.57514
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, SLC22A2, SRC, TRPV1 3.54066
[CC] GO:0044464 cell part ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 3.23569
[CC] GO:0016021 None ABCG2, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CHRM2, CNR1, CNR2, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTGES, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TBXAS1, TEK, TRPV1, TYR 3.2187
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PRKCG, PTGS2, SRC, TEK 3.20644
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.19313
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM2, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PRKCG, PTGS2, SRC, TEK 2.88196
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FLT3, GRIA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGES, PTGS1, PTGS2, PTPN1, TBXAS1 2.83997
[CC] GO:0009330 None TOP1, TOP2A 2.7828
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, PTGES, SRC, TYR 2.77551
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GRIA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTGES, PTGS1, PTGS2, TBXAS1 2.75459
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, GRIK5, HSPA1A, HTR5A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 2.64561
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR4, HTR5A, INSR, KDR, KIT, MIF, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TOP1, TOP2A, TRPV1, TYR, XDH 2.63293
[CC] GO:0045121 membrane raft APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.51647
[CC] GO:0098857 membrane microdomain APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.49883
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, SLC22A1, TEK 2.28856
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 2.14841
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 2.14841
[CC] GO:0031233 None CA4, F10, F3 2.1097
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 16.7789
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 15.9662
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, TRPV1 15.9024
[MF] GO:0030594 None CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.4975
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.4975
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.0737
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.0737
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.0737
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.0737
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, PRKCE, RORC, SMAD3, TEK, TRPV1 14.4574
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, TRPV1 14.4425
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.4063
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, TRPV1 13.98
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TOP2A, TRPV1, TYR, XDH 12.4842
[MF] GO:0008227 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.1906
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK, TRPV1 12.0252
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK, TRPV1 12.0252
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 10.881
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 10.8719
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3 9.93093
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH 9.81697
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.69542
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.47522
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 8.31404
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 7.71305
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.58794
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TOP2A, TRPV1, TYR, XDH 7.46182
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.40931
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 7.18545
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 6.72808
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 6.57616
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.42062
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.32075
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC, TBXAS1 6.1201
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 6.00023
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 5.94549
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.92549
[MF] GO:0004930 None ADORA1, ADORA3, CHRM2, CNR1, CNR2, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.83431
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC, TBXAS1 5.83244
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 5.78112
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.46096
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1, TYR 5.4188
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, NQO2, POLA1, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH 5.41269
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 5.31121
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 5.30461
[MF] GO:0005496 steroid binding AR, ESR1, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC 5.28135
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC 5.19182
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.98388
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 4.85784
[MF] GO:1901363 heterocyclic compound binding ABCG2, ADORA1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, XDH 4.78183
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.71384
[MF] GO:0097159 organic cyclic compound binding ABCG2, ADORA1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, XDH 4.52317
[MF] GO:0005524 ATP binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 4.32347
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 4.26146
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.19014
[MF] GO:0032559 adenyl ribonucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 4.15916
[MF] GO:0030554 adenyl nucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 4.10663
[MF] GO:0043168 anion binding ABCG2, ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, SLC1A1, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 4.01665
[MF] GO:0015238 None ABCG2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.94045
[MF] GO:0000166 nucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 3.89914
[MF] GO:1901265 nucleoside phosphate binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 3.89612
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, F3, GRM5, HSPA1A, KIT, MET, MIF, NR3C1, PGR, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 3.83947
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC, TRPV1 3.67718
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.57021
[MF] GO:0003674 molecular_function ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 3.35921
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.35797
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, PGR, PPARA, RORC 3.20437
[MF] GO:0004879 nuclear receptor activity AR, ESR1, PGR, PPARA, RORC 3.20437
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 3.04307
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.04307
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 3.01231
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TOP1 3.00032
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.99433
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.88196
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.79362
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 2.79088
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.7828
[MF] GO:0003845 None HSD11B1, HSD11B2 2.7828
[MF] GO:0008389 None CYP2A13, CYP2A6 2.7828
[MF] GO:0035403 None PRKCA, PRKCB 2.7828
[MF] GO:0071886 None HTR2A, HTR2C 2.7828
[MF] GO:0042802 identical protein binding ABCG2, ACHE, APP, BCL2, CSNK2A1, EGFR, ESR1, FLT3, GRIK5, IGF1R, KDR, KIT, MET, MIF, MMP9, NQO2, PGR, PTGS2, SLC22A1, SMAD3, TOP2A, TRPV1, TYR, XDH 2.7828
[MF] GO:0097367 carbohydrate derivative binding ABCG2, ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 2.72449
[MF] GO:0032555 purine ribonucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 2.70468
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.70112
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, POLA1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.69951
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, POLA1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.68253
[MF] GO:0017076 purine nucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 2.68031
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.67328
[MF] GO:0032553 ribonucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 2.67328
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.66099
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.5926
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.46291
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.46291
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, TOP1 2.45826
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.44099
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.42461
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.38397
[MF] GO:0015307 None SLC47A1, SLC47A2 2.38397
[MF] GO:1901375 None SLC22A1, SLC22A2 2.38397
[MF] GO:0004949 None CNR1, CNR2 2.38397
[MF] GO:0005333 None SLC22A1, SLC22A2 2.38397
[MF] GO:0005277 None SLC22A1, SLC22A2 2.38397
[MF] GO:0099583 None GRM1, GRM5 2.38397
[MF] GO:0008513 None SLC22A1, SLC22A2 2.38397
[MF] GO:0004699 None PRKCD, PRKCE 2.38397
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.29092
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.16462
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.16462
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.1641
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.15216
[MF] GO:0004971 None GRIA2, GRIA4 2.13133
[MF] GO:0051425 None APP, INSR 2.13133


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, GRIK5, HTR2B, HTR2C, HTR2A, NR3C1, HTR4, GRM1, GRM3, HTR6, GRM5, HTR7, CNR2, CNR1, ADORA3, GRM8, ADORA1, GRIA4, HTR1E, GPR35, HTR1D, HTR1A, HTR1B, TRPV1, HTR5A 21.208
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, HTR1E, PRKCB, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 20.1814
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.4494
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, HTR2B, HTR2C, PRKCA, PIK3CB, TRPV1, HTR2A 10.6674
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, PRKCB, HTR2B, HTR2C, PRKCA, HTR2A, HTR5A, HTR4, GRM1, EGFR, HTR6, GRM5, HTR7 9.9957
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 9.4102
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4, HCAR2, HTR6, PIK3CA, ADORA1, PPARA, GRIA4 9.512
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.512
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, CNR1, KIT, KDR, TEK, MET 9.3162
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, AR, PIK3CA, KIT, BCL2, MET 8.656
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, PRKCG, GRIA2, GRM5, PRKCB, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 8.9686
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 8.5867
Gap junction_Homo sapiens_hsa04540 PRKCG, GRM5, PRKCB, SRC, HTR2B, HTR2C, PRKCA, HTR2A, GRM1, EGFR 8.8362
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, GRM1, EGFR, HSPA1A 8.4185
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PRKCB, INSR, PRKCA, PIK3CB, EGFR, IGF1R, HTR7, PIK3CA, KIT, KDR, TEK, MET 8.0724
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB, NR3C2 8.9918
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 8.2748
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.637
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 7.1761
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, GRIA2, GRM5, PRKCB, CNR1, PRKCA, PTGS2, GRM1, GRIA4 7.1761
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, KIT, GRM8, PRKCA, PIK3CB, GRM1, EGFR 7.007
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, PIK3CA, BCL2, PIM1, CYP1B1, MET 6.8162
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 6.683
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.7937
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.019
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 6.6247
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 5.9212
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, PIK3CA, PRKCB, BCL2, PRKCA, PIK3CB 5.7791
Glioma_Homo sapiens_hsa05214 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 6.1819
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, INSR, KIT, KDR, BCL2, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 5.3883
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 5.8259
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.6247
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 5.3883
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.2158
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.5382
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 4.7595
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 5.3365
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 4.6289
Long-term depression_Homo sapiens_hsa04730 PRKCG, GRIA2, PRKCB, PRKCA, GRM1, IGF1R 5.1809
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 3.9788
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.6289
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.3059
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1 4.9682
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 4.9404
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGES, PTGS1 5.1073
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 4.2979
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 4.2513
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.2076
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 3.3611
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.7513
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PRKCE, ADORA1, PIK3CB 2.9122
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PGR, PIK3CB, CDC25B, IGF1R 3.1043
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, GRM1 3.4072
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.1532
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 2.7293
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, KIT, PRKCA, TYR 3.0771
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.1043
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.0771
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 3.7238
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 2.7293
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.7731
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 2.7462
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.0472
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.8377
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.9263
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.1483
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 2.6404
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.569
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.1678
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.4824
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.1754
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.1969
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.219
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2533
Axon guidance_Homo sapiens_hsa04360 MET 0.2663
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 2.1393
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 1.9059
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3217
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3314
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.7703
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.0271
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3486
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.5129
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5308
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5102
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 4.4744
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.1101
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3638
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3649
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.3816
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 1.9855
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 1.9404
Peroxisome_Homo sapiens_hsa04146 XDH 0.3831
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB, EGFR 1.8416
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 2.797
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.6692
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 2.691
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.3321
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.8611
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.3735
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7053
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.406
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.6521
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 1.8447
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.5336
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, PIK3CA, PIK3CB 1.0676
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.344
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 1.7433
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.7178
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4366
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.5357
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.7989
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.4496
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.4217
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 1.8005
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.8283
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.3398
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.3087
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.5835
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.1769
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 1.667
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.8091
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.506
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 2.8941
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7426
Shigellosis_Homo sapiens_hsa05131 SRC 0.4603
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4632
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.3064
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9101
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9205
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.479
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5129
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5129
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.994
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.6317
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.5308
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.6739
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.0502
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 1.8768
Malaria_Homo sapiens_hsa05144 MET 0.5421
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 1.8283
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 1.8283
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.0676
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 1.9038
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.3121
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1, ABCG2 1.8447
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.0834
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8768
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 1.8447
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 1.9133
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1259
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.58
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.1573
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1944
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6137
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.66
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3058
DNA replication_Homo sapiens_hsa03030 POLA1 0.6519
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.702
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.331
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7484
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.3271
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3747
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7093
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7575
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.5867
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.4496
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4807
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7484
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6813
Tyrosine metabolism_Homo sapiens_hsa00350 MIF, TYR 1.5759
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.639
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.6209
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5563
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.706
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.857
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9187
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9931
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0516


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)