Component: Aconitum carmichaeli 生附子

Description of the Component

Component ID
Latin Name
Aconitum carmichaeli
English Name
Prepared common monkshood daughter root
Chinese Pinyin Name
Sheng Fu Zi
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Geo-authentic habitats (道地产区)
Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx531 Yang He Jie Ning Ointment 阳和解凝膏

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1438 Plasmodium falciparum

Ingredient Structrues

Ingredient ID: TCMC49
Formula: C10H13NO2

Ingredient ID: TCMC486
Formula: C6H7NO

Ingredient ID: TCMC437
Formula: C6H7NO

Ingredient ID: TCMC2545
Formula: C6H7NO

Ingredient ID: TCMC226
Formula: C16H17NO3

Ingredient ID: TCMC1988
Formula: C6H7NO

Ingredient ID: TCMC1374
Formula: C6H12O6


Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC49 C10H13NO2 (1S)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline-6,7-Diol 179.09 -1.0729 2.23 0.899 1 3 52.49 3 2 13 0
TCMC226 C16H17NO3 1-(4-Hydroxy-Benzyl)-1,2,3,4-Tetrahydro-Isoquinoline-6,7-Diol 271.12 -1.5221 2.78 2.146 1 4 72.72 5 3 20 0
TCMC437 C6H7NO 3-Aminophenol 109.05 -1.2102 1.9 0.803 1 2 46.25 2 1 8 0
TCMC486 C6H7NO 4-Aminophenol 109.05 -1.2102 1.9 0.803 1 2 46.25 2 1 8 0
TCMC1374 C6H12O6 Inositol 180.06 -3.0642 1.46 -1.458 6 6 121.38 6 1 12 1
TCMC1988 C6H7NO Questiomycin B 109.05 -1.2102 1.9 1.232 1 2 46.25 2 1 8 0
TCMC2545 C6H7NO O-Phenylhydroxylamine 109.05 -0.7496 1.9 1.534 0 1 35.25 2 1 8 0

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)