NPASS Compound

Natural Product: NPC611971

Natural Product ID	NPC611971
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	XDXDZDZNSLXDNA-TZNDIEGXSA-N
IUPAC Name	n.a.
Synonyms
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	CHEMBL1117
PubChem CID	n.a.
Chemical Classification	CHEMONTID:0000000 [Organic compounds]

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 63 67 0 0 0 0 0 0 0 0999 V2000 -0.6313 5.7057 -0.9582 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.9822 4.2779 -1.0370 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.9448 3.9257 -1.6742 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.1614 3.2691 -0.3393 C 0 0 2 0 0 0 0 0 0 0 0 0 0.8810 3.9247 0.3125 O 0 0 0 0 0 0 0 0 0 0 0 0 0.4766 2.4260 -1.4260 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2214 1.3106 -0.7758 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5193 1.0042 -0.9647 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2695 1.7642 -1.8586 O 0 0 0 0 0 0 0 0 0 0 0 0 3.1452 -0.0430 -0.3021 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3771 -0.7659 0.5679 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0479 -0.4669 0.7734 C 0 0 0 0 0 0 0 0 0 0 0 0 0.3107 -1.2428 1.6817 O 0 0 0 0 0 0 0 0 0 0 0 0 0.4487 0.5690 0.1096 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.9669 0.9838 0.2453 C 0 0 1 0 0 0 0 0 0 0 0 0 -1.6664 0.1164 0.9476 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.7262 -0.5219 0.4146 C 0 0 1 0 0 0 0 0 0 0 0 0 -2.5318 -2.0037 0.4011 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.8484 -2.7387 0.1331 C 0 0 2 0 0 0 0 0 0 0 0 0 -3.5213 -4.0030 -0.4612 N 0 0 0 0 0 0 0 0 0 0 0 0 -4.6855 -1.8415 -0.7456 C 0 0 2 0 0 0 0 0 0 0 0 0 -4.0087 -1.6735 -1.9452 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.9629 -0.5757 0.0036 C 0 0 2 0 0 0 0 0 0 0 0 0 -5.2218 0.6090 -0.9138 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.9757 -0.2652 0.9429 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.9901 2.4465 0.6380 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0200 -1.8826 1.2823 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3057 -2.5414 2.0801 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4411 -2.1944 1.0542 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9844 -3.2616 1.7596 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3120 -3.5721 1.5614 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0541 -2.8219 0.6777 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5350 -1.7649 -0.0277 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2085 -1.4597 0.1745 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5434 -0.3583 -0.5191 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2311 0.3245 -1.3276 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.5094 6.3315 -0.6618 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.2380 6.1204 -1.9209 H 0 0 0 0 0 0 0 0 0 0 0 0 0.1581 5.8817 -0.1711 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8352 3.7468 1.2854 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.2357 2.0155 -2.1478 H 0 0 0 0 0 0 0 0 0 0 0 0 1.2522 3.0693 -1.8974 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5134 2.7010 -1.5564 H 0 0 0 0 0 0 0 0 0 0 0 0 0.3951 -1.0137 2.6626 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.3905 0.9989 -0.8149 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.7967 -0.1764 -0.6591 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.8184 -2.3496 -0.3775 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.1106 -2.3652 1.3803 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.4143 -2.8556 1.0866 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.5140 -4.2272 -0.3712 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.1276 -4.7870 -0.0784 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.6259 -2.4101 -0.9613 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.1038 -2.4121 -2.5626 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.9019 -0.7280 0.5816 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.5042 1.4324 -0.6173 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.2173 1.0341 -0.7862 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.9411 0.3734 -1.9626 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.5290 2.5793 1.6335 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.0233 2.8252 0.5500 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3703 -3.8219 2.4398 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7449 -4.3903 2.0966 H 0 0 0 0 0 0 0 0 0 0 0 0 8.0985 -3.0574 0.5141 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1270 -1.1740 -0.7265 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 2 0 2 4 1 0 4 5 1 1 4 6 1 0 6 7 1 0 7 8 2 0 8 9 1 0 8 10 1 0 10 11 2 0 11 12 1 0 12 13 1 0 12 14 2 0 14 15 1 0 15 16 1 0 16 17 1 0 17 18 1 0 18 19 1 0 19 20 1 0 19 21 1 0 21 22 1 0 21 23 1 0 23 24 1 0 23 25 1 0 15 26 1 0 11 27 1 0 27 28 2 0 27 29 1 0 29 30 2 0 30 31 1 0 31 32 2 0 32 33 1 0 33 34 2 0 34 35 1 0 35 36 2 0 26 4 1 0 34 29 1 0 14 7 1 0 25 17 1 0 35 10 1 0 1 37 1 0 1 38 1 0 1 39 1 0 5 40 1 0 6 41 1 0 6 42 1 0 9 43 1 0 13 44 1 0 15 45 1 6 17 46 1 6 18 47 1 0 18 48 1 0 19 49 1 1 20 50 1 0 20 51 1 0 21 52 1 6 22 53 1 0 23 54 1 1 24 55 1 0 24 56 1 0 24 57 1 0 26 58 1 0 26 59 1 0 30 60 1 0 31 61 1 0 32 62 1 0 33 63 1 0 M END

Standard InCHIKey	XDXDZDZNSLXDNA-TZNDIEGXSA-N
Standard InCHI	InChI=1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1
SMILES	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O

Calculated Properties

Physi-Chem Properties

MedChem Properties

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

ADMET: Distribution

ADMET: Metabolism

ADMET: Excretion

ADMET: Toxicity

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO53222	Streptomyces peucetius var. caesius	Genus	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	Database[COCONUT]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
Potency	113
IC50	174
Ki	132
AC50	58
Activity	6
Inhibition	8
MIC	6
DILI_Concern	1
PHOSLPD_CHANGE	2
Hepatotoxicity (malignant tumour)	1
GI50	1
SGPT Increase - Number of Reports	1
GGT Increase - Number of Reports	1
Hepatotoxicity (acute)	2
SGPT Increase - Index Value	1
Phospholipidosis	1
HepSE_hepatomegaly	1
HepSE_liver function tests abnormal	1
HepSE_cholecystitis	1
ALB_CHANGE	2
HepSE_cholelithiasis	1
Composite Activity - Active	1
CHOL_CHANGE	2
Incidence	4
Hepatotoxicity (comment)	1
WBC_CHANGE	4
LDH Increase - Number of Reports	1
TRIG_CHANGE	2
GGT Increase - Index Value	1
Imax	2
Ratio IC50	3
Alkaline Phosphatase Increase - Index Value	1
HepSE_jaundice	2
SGOT Increase - Number of Reports	1
SGPT Increase - Activity Score	1
HepSE_cirrhosis	1
Alkaline Phosphatase Increase - Number of Reports	1
Composite Activity - Score	1
Alkaline Phosphatase Increase - Activity Score	1
HepSE_bilirubinemia	1
HepSE_hepatic necrosis	1
HepSE_liver fatty	1
SGOT Increase - Activity Score	1
HepSE_hepatic failure	1
Composite Activity - Marginal	1
Hepatotoxicity (mechanism)	1
HepSE_Combined Scores	1
SGOT Increase - Index Value	1
GGT Increase - Activity Score	1
LDH Increase - Index Value	1
LDH Increase - Activity Score	1
Hepatotoxicity (cytolytic)	1
Hepatotoxicity (association with vascular disease)	1
Hepatotoxicity (moderate)	2
Hepatotoxicity (cirrhosis)	1
CC50	2
HepSE_liver disease	1
Hepatotoxicity (benign tumour)	1
Hepatotoxicity (steatosis)	1
Hepatotoxicity (chronic liver disease)	1
Hepatotoxicity (time to onset)	1
Hepatotoxicity (severe hepatitis)	1
Hepatotoxicity (granulomatous hepatitis)	1
Hepatotoxicity (choleostasis)	1
Hepatotoxicity (successful reintroduction)	1
Hepatotoxicity (animal toxicity known)	1
HepSE_hepatitis	1
HepSE_elevated liver function tests	1
Mortality	1
GLUC	17
URATE	17
EOS	15
LYMLE	17
BILI	17
PROT	17
MCHC	17
BASOLE	17
LIPASE	17
ALP	17
PHOS	17
CK	17
MONO	15
RBC	17
MCV	17
CREAT	17
BASO	15
ALB	17
EOSLE	17
MCH	17
MONOLE	17
ALT	17
LYM	15
CHLORIDE	17
SODIUM	17
CHOL	17
PLAT	17
LDH	17
POTASSIUM	17
HGB	17
WBC	17
NEUTLE	17
AST	17
HCT	17
NEUTSG	6
RBCNUC	6
Tissue Severity Score	124
BUN	17
CO2	17

Activity Type	# Activity
Individual protein	325
Cell line	16
Single protein	18
Unchecked	114
Organism	779
Phenotype	34
Protein complex group	2
Non-molecular	24
Protein-protein interaction	4

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT10	Individual protein	Geminin	Homo sapiens	Potency	n.a.	29092.9	nM	PubChem BioAssay data set
NPT198	Individual protein	Vitamin D receptor	Homo sapiens	Potency	n.a.	6309.6	nM	PubChem BioAssay data set
NPT257	Individual protein	Arachidonate 15-lipoxygenase	Oryctolagus cuniculus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT260	Individual protein	Melanocortin receptor 5	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT252	Individual protein	Histamine H2 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT224	Individual protein	Alpha-2c adrenergic receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT224	Individual protein	Alpha-2c adrenergic receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT242	Individual protein	Dopamine D1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT239	Individual protein	Cholecystokinin A receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT30	Individual protein	Cyclooxygenase-1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT245	Individual protein	Dopamine D4 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT246	Individual protein	Dopamine transporter	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT108	Individual protein	Estrogen receptor alpha	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT2769	Individual protein	Thromboxane A2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT262	Individual protein	Muscarinic acetylcholine receptor M1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT14	Individual protein	Tyrosine-protein kinase FYN	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT270	Individual protein	Nitric oxide synthase, inducible	Mus musculus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT135	Individual protein	Chromobox protein homolog 1	Homo sapiens	Potency	n.a.	39810.7	nM	PubChem BioAssay data set
NPT297	Individual protein	Neurokinin 1 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT105	Individual protein	Muscleblind-like protein 1	Homo sapiens	Potency	n.a.	7943.3	nM	PubChem BioAssay data set
NPT1038	Individual protein	Histone-lysine N-methyltransferase MLL	Homo sapiens	Potency	=	39810.7	nM	PubChem BioAssay data set
NPT286	Individual protein	Receptor protein-tyrosine kinase erbB-2	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT242	Individual protein	Dopamine D1 receptor	Homo sapiens	Potency	n.a.	11220.2	nM	PubChem BioAssay data set
NPT301	Individual protein	Vascular endothelial growth factor receptor 1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT280	Individual protein	Matrix metalloproteinase 9	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT289	Individual protein	Serotonin 1b (5-HT1b) receptor	Rattus norvegicus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT275	Individual protein	Progesterone receptor	Bos taurus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT300	Individual protein	Thromboxane-A synthase	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT228	Individual protein	Norepinephrine transporter	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT213	Individual protein	Cytochrome P450 2C19	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT251	Individual protein	Histamine H1 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT220	Individual protein	Alpha-1b adrenergic receptor	Rattus norvegicus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT204	Individual protein	Acetylcholinesterase	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT292	Individual protein	Serotonin 2c (5-HT2c) receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT232	Individual protein	Cannabinoid CB1 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT109	Individual protein	Cytochrome P450 3A4	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT244	Individual protein	Dopamine D3 receptor	Homo sapiens	AC50	=	17000.0	nM	PMID[37468498]
NPT217	Individual protein	Adenosine A2a receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT265	Individual protein	Muscarinic acetylcholine receptor M4	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT287	Individual protein	Leukocyte common antigen	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT298	Individual protein	Neurokinin 2 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT240	Individual protein	Cytochrome P450 2A6	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT241	Individual protein	Cytochrome P450 2E1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT251	Individual protein	Histamine H1 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT260	Individual protein	Melanocortin receptor 5	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT274	Individual protein	Platelet activating factor receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT14	Individual protein	Tyrosine-protein kinase FYN	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT290	Individual protein	Serotonin 2a (5-HT2a) receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT292	Individual protein	Serotonin 2c (5-HT2c) receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT264	Individual protein	Muscarinic acetylcholine receptor M3	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT279	Individual protein	Leukocyte elastase	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT13	Individual protein	Tyrosine-protein kinase LCK	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT182	Individual protein	Protein kinase C alpha	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT295	Individual protein	Serotonin transporter	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT239	Individual protein	Cholecystokinin A receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT244	Individual protein	Dopamine D3 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT264	Individual protein	Muscarinic acetylcholine receptor M3	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT273	Individual protein	Phosphodiesterase 5A	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT276	Individual protein	Angiotensin-converting enzyme	Oryctolagus cuniculus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT269	Individual protein	Nitric-oxide synthase, brain	Rattus norvegicus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT199	Individual protein	DNA polymerase kappa	Homo sapiens	Potency	n.a.	26679.5	nM	PubChem BioAssay data set
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	AC50	=	14000.1	nM	PMID[37468498]
NPT276	Individual protein	Angiotensin-converting enzyme	Oryctolagus cuniculus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT289	Individual protein	Serotonin 1b (5-HT1b) receptor	Rattus norvegicus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT290	Individual protein	Serotonin 2a (5-HT2a) receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT261	Individual protein	Monoamine oxidase A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT299	Individual protein	Androgen Receptor	Rattus norvegicus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT291	Individual protein	Serotonin 2b (5-HT2b) receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT300	Individual protein	Thromboxane-A synthase	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT216	Individual protein	Adenosine A1 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT237	Individual protein	Interleukin-8 receptor A	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT243	Individual protein	Dopamine D2 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT233	Individual protein	Carbonic anhydrase II	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT220	Individual protein	Alpha-1b adrenergic receptor	Rattus norvegicus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	AC50	=	18999.8	nM	PMID[37468498]
NPT1038	Individual protein	Histone-lysine N-methyltransferase MLL	Homo sapiens	Potency	=	19952.6	nM	PubChem BioAssay data set
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT104	Individual protein	Cerebroside-sulfatase	Homo sapiens	Potency	n.a.	11995.5	nM	PubChem BioAssay data set
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT232	Individual protein	Cannabinoid CB1 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT213	Individual protein	Cytochrome P450 2C19	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT262	Individual protein	Muscarinic acetylcholine receptor M1	Homo sapiens	AC50	=	23000.1	nM	PMID[37468498]
NPT303	Individual protein	Vasopressin V1a receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT223	Individual protein	Alpha-2b adrenergic receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT217	Individual protein	Adenosine A2a receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT252	Individual protein	Histamine H2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT236	Individual protein	C-C chemokine receptor type 5	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT237	Individual protein	Interleukin-8 receptor A	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT217	Individual protein	Adenosine A2a receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT262	Individual protein	Muscarinic acetylcholine receptor M1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT1163	Individual protein	Glutamate (NMDA) receptor subunit zeta 1	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT266	Individual protein	Muscarinic acetylcholine receptor M5	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT263	Individual protein	Muscarinic acetylcholine receptor M2	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT256	Individual protein	Cysteinyl leukotriene receptor 1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT110	Individual protein	Cytochrome P450 2D6	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT243	Individual protein	Dopamine D2 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT182	Individual protein	Protein kinase C alpha	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT13	Individual protein	Tyrosine-protein kinase LCK	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT216	Individual protein	Adenosine A1 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT219	Individual protein	Alpha-1a adrenergic receptor	Rattus norvegicus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT298	Individual protein	Neurokinin 2 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT1623	Individual protein	DNA polymerase III	Bacillus subtilis (strain 168)	Potency	n.a.	1062.1	nM	PubChem BioAssay data set
NPT199	Individual protein	DNA polymerase kappa	Homo sapiens	Potency	n.a.	7943.3	nM	PubChem BioAssay data set
NPT269	Individual protein	Nitric-oxide synthase, brain	Rattus norvegicus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT1594	Individual protein	Multidrug resistance-associated protein 1	Homo sapiens	Activity	=	52.0	%	PMID[9188796]
NPT245	Individual protein	Dopamine D4 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT283	Individual protein	MAP kinase p38 alpha	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT285	Individual protein	Epidermal growth factor receptor erbB1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT286	Individual protein	Receptor protein-tyrosine kinase erbB-2	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT218	Individual protein	Adenosine A3 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT1410	Individual protein	GABA receptor alpha-1 subunit	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT1098	Individual protein	Eyes absent homolog 2	Homo sapiens	Potency	n.a.	125892.5	nM	PubChem BioAssay data set
NPT273	Individual protein	Phosphodiesterase 5A	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT296	Individual protein	Sigma opioid receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT274	Individual protein	Platelet activating factor receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT275	Individual protein	Progesterone receptor	Bos taurus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT270	Individual protein	Nitric oxide synthase, inducible	Mus musculus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT257	Individual protein	Arachidonate 15-lipoxygenase	Oryctolagus cuniculus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT256	Individual protein	Cysteinyl leukotriene receptor 1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT259	Individual protein	Melanocortin receptor 4	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT236	Individual protein	C-C chemokine receptor type 5	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT10	Individual protein	Geminin	Homo sapiens	Potency	=	1995.3	nM	PubChem BioAssay data set
NPT212	Individual protein	Cytochrome P450 2C9	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT241	Individual protein	Cytochrome P450 2E1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT281	Individual protein	MAP kinase ERK1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT301	Individual protein	Vascular endothelial growth factor receptor 1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT31	Individual protein	Cyclooxygenase-2	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT225	Individual protein	Beta-1 adrenergic receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT255	Individual protein	Leukotriene C4 synthase	Cavia porcellus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT244	Individual protein	Dopamine D3 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT108	Individual protein	Estrogen receptor alpha	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT242	Individual protein	Dopamine D1 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT234	Individual protein	C-C chemokine receptor type 2	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT248	Individual protein	Estrogen receptor beta	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT253	Individual protein	HMG-CoA reductase	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT204	Individual protein	Acetylcholinesterase	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT229	Individual protein	Angiotensin II type 2 (AT-2) receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT240	Individual protein	Cytochrome P450 2A6	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT277	Individual protein	Caspase-1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT242	Individual protein	Dopamine D1 receptor	Homo sapiens	Potency	n.a.	2909.1	nM	PubChem BioAssay data set
NPT288	Individual protein	Serotonin 1a (5-HT1a) receptor	Rattus norvegicus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT293	Individual protein	Serotonin 4 (5-HT4) receptor	Cavia porcellus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT303	Individual protein	Vasopressin V1a receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT303	Individual protein	Vasopressin V1a receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT294	Individual protein	Serotonin 6 (5-HT6) receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT285	Individual protein	Epidermal growth factor receptor erbB1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT230	Individual protein	Bradykinin B2 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT208	Individual protein	Cytochrome P450 1A2	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT208	Individual protein	Cytochrome P450 1A2	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT212	Individual protein	Cytochrome P450 2C9	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT259	Individual protein	Melanocortin receptor 4	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT248	Individual protein	Estrogen receptor beta	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT267	Individual protein	Neuropeptide Y receptor type 1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT2719	Individual protein	Voltage-gated L-type calcium channel alpha-1C subunit	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT31	Individual protein	Cyclooxygenase-2	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT235	Individual protein	C-C chemokine receptor type 4	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT235	Individual protein	C-C chemokine receptor type 4	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT293	Individual protein	Serotonin 4 (5-HT4) receptor	Cavia porcellus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT295	Individual protein	Serotonin transporter	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT282	Individual protein	MAP kinase ERK2	Homo sapiens	Potency	=	22387.2	nM	PubChem BioAssay data set
NPT228	Individual protein	Norepinephrine transporter	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT279	Individual protein	Leukocyte elastase	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT233	Individual protein	Carbonic anhydrase II	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT223	Individual protein	Alpha-2b adrenergic receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT281	Individual protein	MAP kinase ERK1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT218	Individual protein	Adenosine A3 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT291	Individual protein	Serotonin 2b (5-HT2b) receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT234	Individual protein	C-C chemokine receptor type 2	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT264	Individual protein	Muscarinic acetylcholine receptor M3	Homo sapiens	AC50	=	14000.1	nM	PMID[37468498]
NPT1197	Individual protein	Huntingtin	Homo sapiens	Potency	=	631.0	nM	PubChem BioAssay data set
NPT267	Individual protein	Neuropeptide Y receptor type 1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT277	Individual protein	Caspase-1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT282	Individual protein	MAP kinase ERK2	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT287	Individual protein	Leukocyte common antigen	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT263	Individual protein	Muscarinic acetylcholine receptor M2	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT266	Individual protein	Muscarinic acetylcholine receptor M5	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT223	Individual protein	Alpha-2b adrenergic receptor	Homo sapiens	AC50	=	17999.9	nM	PMID[37468498]
NPT246	Individual protein	Dopamine transporter	Homo sapiens	AC50	=	15000.0	nM	PMID[37468498]
NPT30	Individual protein	Cyclooxygenase-1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT225	Individual protein	Beta-1 adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT255	Individual protein	Leukotriene C4 synthase	Cavia porcellus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT253	Individual protein	HMG-CoA reductase	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT242	Individual protein	Dopamine D1 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT295	Individual protein	Serotonin transporter	Homo sapiens	AC50	=	7300.0	nM	PMID[37468498]
NPT239	Individual protein	Cholecystokinin A receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT267	Individual protein	Neuropeptide Y receptor type 1	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT246	Individual protein	Dopamine transporter	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT110	Individual protein	Cytochrome P450 2D6	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT227	Individual protein	Beta-3 adrenergic receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT247	Individual protein	Endothelin receptor ET-A	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT247	Individual protein	Endothelin receptor ET-A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT230	Individual protein	Bradykinin B2 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT31	Individual protein	Cyclooxygenase-2	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT1044	Individual protein	DNA topoisomerase II alpha	Homo sapiens	IC50	=	2.6	nM	PMID[37847948]
NPT225	Individual protein	Beta-1 adrenergic receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	AC50	=	110.0	nM	PMID[37468498]
NPT243	Individual protein	Dopamine D2 receptor	Homo sapiens	AC50	=	10999.9	nM	PMID[37468498]
NPT228	Individual protein	Norepinephrine transporter	Homo sapiens	AC50	=	8700.0	nM	PMID[37468498]
NPT299	Individual protein	Androgen Receptor	Rattus norvegicus	AC50	=	17000.0	nM	PMID[37468498]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1464	Individual protein	Phosphodiesterase 4D	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1647	Individual protein	Vasopressin V2 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT218	Individual protein	Adenosine A3 receptor	Homo sapiens	AC50	=	20000.0	nM	PMID[37468498]
NPT224	Individual protein	Alpha-2c adrenergic receptor	Homo sapiens	AC50	=	10000.0	nM	PMID[37468498]
NPT292	Individual protein	Serotonin 2c (5-HT2c) receptor	Homo sapiens	AC50	=	9299.9	nM	PMID[37468498]
NPT216	Individual protein	Adenosine A1 receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT1005	Individual protein	Tumor susceptibility gene 101 protein	Homo sapiens	Potency	n.a.	7943.3	nM	PubChem BioAssay data set
NPT198	Individual protein	Vitamin D receptor	Homo sapiens	Potency	n.a.	8912.5	nM	PubChem BioAssay data set
NPT294	Individual protein	Serotonin 6 (5-HT6) receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT296	Individual protein	Sigma opioid receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT299	Individual protein	Androgen Receptor	Rattus norvegicus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT227	Individual protein	Beta-3 adrenergic receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT221	Individual protein	Alpha-1d adrenergic receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT282	Individual protein	MAP kinase ERK2	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT284	Individual protein	Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT297	Individual protein	Neurokinin 1 receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT252	Individual protein	Histamine H2 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT261	Individual protein	Monoamine oxidase A	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT247	Individual protein	Endothelin receptor ET-A	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT109	Individual protein	Cytochrome P450 3A4	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT229	Individual protein	Angiotensin II type 2 (AT-2) receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT230	Individual protein	Bradykinin B2 receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT2879	Individual protein	Equilibrative nucleoside transporter 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT251	Individual protein	Histamine H1 receptor	Homo sapiens	AC50	=	10000.0	nM	PMID[37468498]
NPT221	Individual protein	Alpha-1d adrenergic receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT219	Individual protein	Alpha-1a adrenergic receptor	Rattus norvegicus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT278	Individual protein	Cathepsin G	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT280	Individual protein	Matrix metalloproteinase 9	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT283	Individual protein	MAP kinase p38 alpha	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT284	Individual protein	Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT288	Individual protein	Serotonin 1a (5-HT1a) receptor	Rattus norvegicus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT265	Individual protein	Muscarinic acetylcholine receptor M4	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT278	Individual protein	Cathepsin G	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT261	Individual protein	Monoamine oxidase A	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT796	Individual protein	Peripheral myelin protein 22	Homo sapiens	Potency	=	425.6	nM	PubChem BioAssay data set
NPT9	Individual protein	DNA polymerase eta	Homo sapiens	Potency	n.a.	14125.4	nM	PubChem BioAssay data set
NPT58	Individual protein	Bloom syndrome protein	Homo sapiens	Potency	=	6461.8	nM	PubChem BioAssay data set
NPT537	Individual protein	Ras-related protein Rab-9A	Homo sapiens	Potency	=	58047.9	nM	PubChem BioAssay data set
NPT5301	Individual protein	Motilin receptor	Homo sapiens	AC50	>	10000.0	nM	PMID[37468498]
NPT531	Individual protein	Nuclear receptor ROR-gamma	Mus musculus	Potency	=	17782.8	nM	PubChem BioAssay data set
NPT803	Individual protein	Flap endonuclease 1	Homo sapiens	Potency	n.a.	26679.5	nM	PubChem BioAssay data set
NPT58	Individual protein	Bloom syndrome protein	Homo sapiens	Potency	=	12589.3	nM	PubChem BioAssay data set
NPT483	Individual protein	Prelamin-A/C	Homo sapiens	Potency	=	316.2	nM	PubChem BioAssay data set
NPT987	Individual protein	Histamine H3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT483	Individual protein	Prelamin-A/C	Homo sapiens	Potency	=	251.2	nM	PubChem BioAssay data set
NPT893	Individual protein	Monoamine oxidase B	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[18834112]
NPT800	Individual protein	M-phase phosphoprotein 8	Homo sapiens	Potency	n.a.	28183.8	nM	PubChem BioAssay data set
NPT940	Individual protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Potency	=	11668.1	nM	PubChem BioAssay data set
NPT940	Individual protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Potency	=	414.0	nM	PubChem BioAssay data set
NPT98	Individual protein	HERG	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT68	Individual protein	Aldose reductase	Rattus norvegicus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT69	Individual protein	Matrix metalloproteinase-1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT29498	Single protein	Interleukin-8 receptor B	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT94	Individual protein	Aldehyde dehydrogenase 1A1	Homo sapiens	Potency	=	28183.8	nM	PubChem BioAssay data set
NPT444	Individual protein	Ubiquitin carboxyl-terminal hydrolase 1	Homo sapiens	Potency	n.a.	39810.7	nM	PubChem BioAssay data set
NPT538	Individual protein	Niemann-Pick C1 protein	Homo sapiens	Potency	=	115820.8	nM	PubChem BioAssay data set
NPT800	Individual protein	M-phase phosphoprotein 8	Homo sapiens	Potency	n.a.	29934.9	nM	PubChem BioAssay data set
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT98	Individual protein	HERG	Homo sapiens	AC50	=	20700.0	nM	PMID[37468498]
NPT940	Individual protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Potency	=	2328.1	nM	PubChem BioAssay data set
NPT69	Individual protein	Matrix metalloproteinase-1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT7	Individual protein	Thioredoxin reductase 1, cytoplasmic	Rattus norvegicus	Potency	n.a.	26679.5	nM	PubChem BioAssay data set
NPT29498	Single protein	Interleukin-8 receptor B	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	-16.45	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT444	Individual protein	Ubiquitin carboxyl-terminal hydrolase 1	Homo sapiens	Potency	n.a.	50118.7	nM	PubChem BioAssay data set
NPT940	Individual protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Potency	=	10399.2	nM	PubChem BioAssay data set
NPT98	Individual protein	HERG	Homo sapiens	Potency	n.a.	10000.0	nM	PubChem BioAssay data set
NPT4729	Individual protein	Cholecystokinin B receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT48	Individual protein	Lysine-specific demethylase 4D-like	Homo sapiens	Potency	=	14125.4	nM	PubChem BioAssay data set
NPT68	Individual protein	Aldose reductase	Rattus norvegicus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT692	Individual protein	Histone deacetylase 6	Homo sapiens	Inhibition	=	9.63	%	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
NPT20556	Single protein	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	13.17	%	Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen
NPT29430	Single protein	Neuronal acetylcholine receptor protein alpha-4 subunit	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT54	Individual protein	Nonstructural protein 1	Influenza A virus	Potency	=	39810.7	nM	PubChem BioAssay data set
NPT98	Individual protein	HERG	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT542	Individual protein	Progesterone receptor	Homo sapiens	AC50	=	5800.0	nM	PMID[37468498]
NPT698	Individual protein	Regulator of G-protein signaling 4	Homo sapiens	Potency	n.a.	37685.8	nM	PubChem BioAssay data set
NPT51	Individual protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	7943.3	nM	PubChem BioAssay data set
NPT46	Individual protein	Thyroid hormone receptor beta-1	Homo sapiens	Potency	=	44668.4	nM	PubChem BioAssay data set
NPT583	Individual protein	Inositol monophosphatase 1	Rattus norvegicus	Potency	=	1995.3	nM	PubChem BioAssay data set
NPT755	Individual protein	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens	Potency	n.a.	26854.5	nM	PubChem BioAssay data set
NPT445	Individual protein	Peripheral myelin protein 22	Rattus norvegicus	Potency	n.a.	99.9	nM	PubChem BioAssay data set
NPT20859	Single protein	Neuropeptide Y receptor type 2	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT51	Individual protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	12589.3	nM	PubChem BioAssay data set
NPT20859	Single protein	Neuropeptide Y receptor type 2	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT478	Individual protein	Ataxin-2	Homo sapiens	Potency	n.a.	19952.6	nM	PubChem BioAssay data set
NPT8	Individual protein	DNA polymerase iota	Homo sapiens	Potency	n.a.	7943.3	nM	PubChem BioAssay data set
NPT794	Individual protein	Endonuclease 4	Escherichia coli K-12	Potency	=	25118.9	nM	PubChem BioAssay data set
NPT30107	Single protein	Amyloid-beta A4 protein	Homo sapiens	Potency	n.a.	23109.3	nM	PubChem BioAssay data set
NPT59	Individual protein	DNA polymerase beta	Homo sapiens	Potency	=	14125.4	nM	PubChem BioAssay data set
NPT478	Individual protein	Ataxin-2	Homo sapiens	Potency	n.a.	100.0	nM	PubChem BioAssay data set
NPT51	Individual protein	Microtubule-associated protein tau	Homo sapiens	Potency	=	3548.1	nM	PubChem BioAssay data set
NPT445	Individual protein	Peripheral myelin protein 22	Rattus norvegicus	Potency	n.a.	3219.7	nM	PubChem BioAssay data set
NPT5975	Individual protein	Cyclooxygenase-1	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT46	Individual protein	Thyroid hormone receptor beta-1	Homo sapiens	Potency	=	28183.8	nM	PubChem BioAssay data set
NPT93	Individual protein	Survival motor neuron protein	Homo sapiens	Potency	=	631.0	nM	PubChem BioAssay data set
NPT29582	Single protein	Son of sevenless homolog 1	Homo sapiens	IC50	=	6000.0	nM	PMID[36987571]
NPT5104	Individual protein	Phosphodiesterase 3A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT28814	Single protein	Ghrelin receptor	Homo sapiens	AC50	=	7700.0	nM	PMID[37468498]
NPT892	Individual protein	Monoamine oxidase A	Mus musculus	Activity	n.a.	n.a.	n.a.	PMID[18834112]
NPT49	Individual protein	DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	Potency	=	15848.9	nM	PubChem BioAssay data set
NPT47	Individual protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	11220.2	nM	PubChem BioAssay data set
NPT47	Individual protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	28183.8	nM	PubChem BioAssay data set
NPT5	Individual protein	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Homo sapiens	Potency	n.a.	12589.3	nM	PubChem BioAssay data set
NPT30151	Single protein	Melanocortin receptor 3	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT543	Individual protein	Pregnane X receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT29442	Protein complex group	Glycine receptor	Rattus norvegicus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT28550	Single protein	Vasoactive intestinal polypeptide receptor 1	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT443	Individual protein	Histone acetyltransferase GCN5	Homo sapiens	Potency	n.a.	22387.2	nM	PubChem BioAssay data set
NPT28398	Single protein	Insulin receptor	Rattus norvegicus	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT64	Individual protein	ATPase family AAA domain-containing protein 5	Homo sapiens	Potency	n.a.	5802.4	nM	PubChem BioAssay data set
NPT49	Individual protein	DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	Potency	=	14125.4	nM	PubChem BioAssay data set
NPT62	Individual protein	6-phospho-1-fructokinase	Trypanosoma brucei	Potency	n.a.	30131.3	nM	PubChem BioAssay data set
NPT45	Individual protein	Ubiquitin carboxyl-terminal hydrolase 2	Homo sapiens	Potency	=	16481.6	nM	PubChem BioAssay data set
NPT30151	Single protein	Melanocortin receptor 3	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT28398	Single protein	Insulin receptor	Rattus norvegicus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT5	Individual protein	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Homo sapiens	Potency	n.a.	3162.3	nM	PubChem BioAssay data set
NPT49	Individual protein	DNA-(apurinic or apyrimidinic site) lyase	Homo sapiens	Potency	n.a.	19952.6	nM	PubChem BioAssay data set
NPT64	Individual protein	ATPase family AAA domain-containing protein 5	Homo sapiens	Potency	n.a.	580.2	nM	PubChem BioAssay data set
NPT442	Individual protein	Ferritin light chain	Equus caballus	Potency	=	39810.7	nM	PubChem BioAssay data set
NPT47	Individual protein	ATP-dependent DNA helicase Q1	Homo sapiens	Potency	=	35481.3	nM	PubChem BioAssay data set
NPT5	Individual protein	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Homo sapiens	Potency	n.a.	13371.4	nM	PubChem BioAssay data set
NPT30010	Single protein	Calcitonin receptor	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT30010	Single protein	Calcitonin receptor	Homo sapiens	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT425	Individual protein	Serotonin 3a (5-HT3a) receptor	Homo sapiens	AC50	=	12999.9	nM	PMID[37468498]
NPT29442	Protein complex group	Glycine receptor	Rattus norvegicus	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT30151	Single protein	Melanocortin receptor 3	Homo sapiens	AC50	=	17999.9	nM	PMID[37468498]
NPT28550	Single protein	Vasoactive intestinal polypeptide receptor 1	Homo sapiens	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT65	Cell line	HepG2	Homo sapiens	IC50	=	12300.0	nM	PMID[22586124]
NPT1160	Cell line	BJ	Homo sapiens	Activity	=	100.0	%	PMID[33513390]
NPT111	Cell line	K562	Homo sapiens	GI50	=	3300.0	nM	PMID[25420175]
NPT111	Cell line	K562	Homo sapiens	IC50	=	2.0	nM	PMID[10425093]
NPT146	Cell line	SK-OV-3	Homo sapiens	IC50	=	4500.0	nM	PMID[24900668]
NPT71	Cell line	HEK293	Homo sapiens	Potency	n.a.	56.2	nM	PubChem BioAssay data set
NPT2502	Cell line	MEL-JUSO	Homo sapiens	IC50	=	89.0	nM	PMID[37561481]
NPT1160	Cell line	BJ	Homo sapiens	Inhibition	=	100.0	%	PMID[34157390]
NPT519	Cell line	SH-SY5Y	Homo sapiens	Potency	n.a.	19952.6	nM	PubChem BioAssay data set
NPT111	Cell line	K562	Homo sapiens	IC50	=	27.0	nM	PMID[37561481]
NPT83	Cell line	MCF7	Homo sapiens	IC50	=	7300.0	nM	PMID[24900668]
NPT1045	Cell line	U2OS	Homo sapiens	IC50	=	24.0	nM	PMID[37561481]
NPT71	Cell line	HEK293	Homo sapiens	Potency	n.a.	259.2	nM	PubChem BioAssay data set
NPT111	Cell line	K562	Homo sapiens	IC50	=	12.0	nM	PMID[18076140]
NPT28438	Unchecked	Unchecked	n.a.	Potency	=	56.2	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Activity	=	82.0	%	PMID[33324471]
NPT28438	Unchecked	Unchecked	n.a.	Ki	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT28438	Unchecked	Unchecked	n.a.	IC50	n.a.	n.a.	n.a.	DrugMatrix in vitro pharmacology data
NPT28438	Unchecked	Unchecked	n.a.	Ac50	n.a.	1.122	uM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (malignant tumour)	=	0.0	n.a.	PMID[15646539]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	0.71	nM	PMID[19734910]
NPT28438	Unchecked	Unchecked	n.a.	Potency	=	562.3	nM	PubChem BioAssay data set
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	1000.0	nM	PMID[19734910]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	>	5000.0	nM	PMID[22586124]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	250000.0	nM	PMID[33324471]
NPT28438	Unchecked	Unchecked	n.a.	Potency	n.a.	39.8	nM	PubChem BioAssay data set
NPT20912	Phenotype	Phospholipidosis	n.a.	Phospholipidosis	n.a.	n.a.	n.a.	PMID[20020916]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Potency	n.a.	3294.4	nM	PubChem BioAssay data set
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	1.05	nM	PMID[19734910]
NPT28438	Unchecked	Unchecked	n.a.	ALB_CHANGE	n.a.	n.a.	n.a.	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
NPT28438	Unchecked	Unchecked	n.a.	AC50	n.a.	28190.0	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Incidence	n.a.	n.a.	n.a.	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (comment)	n.a.	n.a.	n.a.	PMID[15646539]
NPT28438	Unchecked	Unchecked	n.a.	WBC_CHANGE	=	35.0	%	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
NPT28438	Unchecked	Unchecked	n.a.	Inhibition	n.a.	n.a.	%	PMID[17417631]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	7300.0	nM	PMID[23591260]
NPT28438	Unchecked	Unchecked	n.a.	Potency	n.a.	707.9	nM	PubChem BioAssay data set
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	1258.93	nM	PMID[19734910]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	1.26	nM	PMID[19734910]
NPT28438	Unchecked	Unchecked	n.a.	Potency	n.a.	32196.8	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Potency	=	3981.1	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Imax	=	590.0	%	PMID[23591260]
NPT28438	Unchecked	Unchecked	n.a.	Ratio IC50	=	5.0	n.a.	PMID[24900668]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	1970.0	nM	PMID[24900668]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	890.0	nM	PMID[24900668]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Potency	n.a.	3696.4	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (acute)	=	1.0	n.a.	PMID[15646539]
NPT28438	Unchecked	Unchecked	n.a.	Potency	=	17782.8	nM	PubChem BioAssay data set
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	1.41	nM	PMID[19734910]
NPT28438	Unchecked	Unchecked	n.a.	Potency	n.a.	2003.1	nM	PubChem BioAssay data set
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Potency	n.a.	3793.3	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Potency	=	28183.8	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Ac50	n.a.	31.62	uM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Potency	n.a.	1122.0	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	WBC_CHANGE	=	55.0	%	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
NPT28438	Unchecked	Unchecked	n.a.	Ratio IC50	=	3.0	n.a.	PMID[24900668]
NPT28438	Unchecked	Unchecked	n.a.	IC50	=	700.0	nM	PMID[23591260]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	33000.0	nM	Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	10.21	%	Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort
NPT28438	Unchecked	Unchecked	n.a.	Potency	n.a.	61078.1	nM	PubChem BioAssay data set
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	1.0	nM	PMID[19734910]
NPT28438	Unchecked	Unchecked	n.a.	AC50	n.a.	31622.8	nM	PubChem BioAssay data set
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	1.17	nM	PMID[19734910]
NPT28438	Unchecked	Unchecked	n.a.	WBC_CHANGE	=	50.0	%	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
NPT28438	Unchecked	Unchecked	n.a.	AC50	n.a.	1122.0	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Potency	n.a.	100391.6	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Ac50	n.a.	28.18	uM	PubChem BioAssay data set
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Inhibition	=	100.0	%	PMID[32945666]
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	IC50	=	630.96	nM	PMID[19734910]
NPT28438	Unchecked	Unchecked	n.a.	Potency	=	794.3	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Imax	=	100.0	%	PMID[23591260]
NPT28438	Unchecked	Unchecked	n.a.	Potency	n.a.	5804.8	nM	PubChem BioAssay data set
NPT6	Organism	Plasmodium falciparum	Plasmodium falciparum	Potency	n.a.	2685.5	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Potency	n.a.	410.8	nM	PubChem BioAssay data set
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (cytolytic)	=	1.0	n.a.	PMID[15646539]
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (association with vascular disease)	=	1.0	n.a.	PMID[15646539]
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (cirrhosis)	=	0.0	n.a.	PMID[15646539]
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (steatosis)	=	0.0	n.a.	PMID[15646539]
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (chronic liver disease)	=	0.0	n.a.	PMID[15646539]
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (severe hepatitis)	=	2.0	n.a.	PMID[15646539]
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (choleostasis)	=	0.0	n.a.	PMID[15646539]
NPT28438	Unchecked	Unchecked	n.a.	Hepatotoxicity (successful reintroduction)	n.a.	n.a.	n.a.	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Potency	=	707.9	nM	PubChem BioAssay data set
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Potency	=	1000.0	nM	PubChem BioAssay data set
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	PHOSLPD_CHANGE	n.a.	n.a.	n.a.	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (acute)	=	0.0	%	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Potency	=	1258.9	nM	PubChem BioAssay data set
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	CHOL_CHANGE	n.a.	n.a.	n.a.	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	TRIG_CHANGE	n.a.	n.a.	n.a.	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	2300.0	nM	PMID[24900668]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Activity	n.a.	n.a.	n.a.	PMID[24900668]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Potency	=	1584.9	nM	PubChem BioAssay data set
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (mechanism)	n.a.	n.a.	n.a.	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	IC50	=	3200.0	nM	PMID[24900668]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Potency	=	1122.0	nM	PubChem BioAssay data set
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (moderate)	=	7.0	n.a.	PMID[15646539]
NPT22224	Cell line	Vero C1008	Chlorocebus sabaeus	CC50	=	200.0	nM	Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (benign tumour)	=	0.0	n.a.	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (moderate)	=	18.2	%	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (time to onset)	n.a.	n.a.	n.a.	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (granulomatous hepatitis)	=	0.0	n.a.	PMID[15646539]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	Hepatotoxicity (animal toxicity known)	n.a.	n.a.	n.a.	PMID[15646539]
NPT28513	Organism	Mycolicibacterium smegmatis	Mycolicibacterium smegmatis	IC50	=	3610.0	nM	PMID[19786608]
NPT28513	Organism	Mycolicibacterium smegmatis	Mycolicibacterium smegmatis	MIC	=	25000.0	nM	PMID[19786608]
NPT28513	Organism	Mycolicibacterium smegmatis	Mycolicibacterium smegmatis	IC50	=	6680.0	nM	PMID[19786608]
NPT605	Organism	Homo sapiens	Homo sapiens	DILI_Concern	n.a.	n.a.	n.a.	PMID[26948801]
NPT28513	Organism	Mycolicibacterium smegmatis	Mycolicibacterium smegmatis	MIC	=	12500.0	nM	PMID[19786608]
NPT474	Organism	Plasmodium berghei	Plasmodium berghei	IC50	=	6620.0	nM	PMID[22586124]
NPT28513	Organism	Mycolicibacterium smegmatis	Mycolicibacterium smegmatis	IC50	=	5130.0	nM	PMID[19786608]
NPT29533	Protein-protein interaction	Menin/Histone-lysine N-methyltransferase MLL	Homo sapiens	Potency	=	1778.3	nM	PubChem BioAssay data set
NPT20596	Phenotype	Hepatotoxicity	n.a.	SGPT Increase - Number of Reports	<	4.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	GGT Increase - Number of Reports	<	4.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	SGPT Increase - Index Value	=	0.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatomegaly	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_liver function tests abnormal	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_cholecystitis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_cholelithiasis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	Composite Activity - Active	=	0.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	LDH Increase - Number of Reports	<	4.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	GGT Increase - Index Value	=	0.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	Alkaline Phosphatase Increase - Index Value	=	0.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_jaundice	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	SGOT Increase - Number of Reports	<	4.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	SGPT Increase - Activity Score	n.a.	n.a.	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_cirrhosis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	Alkaline Phosphatase Increase - Number of Reports	<	4.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	Composite Activity - Score	n.a.	n.a.	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	Alkaline Phosphatase Increase - Activity Score	n.a.	n.a.	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_bilirubinemia	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatic necrosis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_liver fatty	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	SGOT Increase - Activity Score	n.a.	n.a.	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatic failure	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	Composite Activity - Marginal	=	0.0	n.a.	PMID[16472241]
NPT29533	Protein-protein interaction	Menin/Histone-lysine N-methyltransferase MLL	Homo sapiens	Potency	=	28183.8	nM	PubChem BioAssay data set
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_Combined Scores	=	0.0	n.a.	PMID[22194678]
NPT29533	Protein-protein interaction	Menin/Histone-lysine N-methyltransferase MLL	Homo sapiens	Potency	=	25118.9	nM	PubChem BioAssay data set
NPT20596	Phenotype	Hepatotoxicity	n.a.	SGOT Increase - Index Value	=	0.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	GGT Increase - Activity Score	n.a.	n.a.	n.a.	PMID[16472241]
NPT29533	Protein-protein interaction	Menin/Histone-lysine N-methyltransferase MLL	Homo sapiens	Potency	=	4466.8	nM	PubChem BioAssay data set
NPT20596	Phenotype	Hepatotoxicity	n.a.	LDH Increase - Index Value	=	0.0	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	LDH Increase - Activity Score	n.a.	n.a.	n.a.	PMID[16472241]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_liver disease	=	0.0	n.a.	PMID[22194678]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT28438	Unchecked	Unchecked	n.a.	Mortality	n.a.	n.a.	n.a.	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_hepatitis	=	0.0	n.a.	PMID[22194678]
NPT20596	Phenotype	Hepatotoxicity	n.a.	HepSE_elevated liver function tests	=	0.0	n.a.	PMID[22194678]
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1493.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	20.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	0.078	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	0.0467	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	66.9	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	1.8	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	62500.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	309000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	1.73	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	13.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	298.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	119.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	261.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1807.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	223.33	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	368700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	5470000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	62.25	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	2.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASO	=	0.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	40000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1165.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	0.0525	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	1.33	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	23.57	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	2.33	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	158.83	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	23.87	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	123.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	38.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	326700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	2.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	6.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	4289.33	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	4.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	104.25	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	0.32	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	0.47	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	0.27	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	113.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	148.0	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	106.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	2.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	635.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	57800.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1359000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	0.82	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	76.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.46	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	259.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	694.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	62000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	0.66	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	7.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.62	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	1.58	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	35.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	91.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.58	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	190.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	130700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	2.1	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	6680000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	13820.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	3.52	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASO	=	0.28	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.2	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	59.76	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.72	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	6.6	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASO	=	0.32	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	32500.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	112.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	2.17	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	135000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	17620.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	45.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	62200.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	149.2	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	3.13	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASO	=	0.1	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1144500.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	136600.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.38	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	911500.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	151.0	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	31.75	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	134000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	150.5	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1755.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	9903.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	97.5	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	102.67	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	80.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	1.33	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.16	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	668.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	89.5	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	370700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	33.3	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1456.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	2.95	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	93.33	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	1052.33	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	1.4	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	7460000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	94.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	372300.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	30.67	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	47.3	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	23.9	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBCNUC	=	0.0	/100WBC	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	145.2	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.35	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1433.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	126000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	0.0	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	5740000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.0	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	8.67	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	13190.83	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	Tissue Severity Score	n.a.	n.a.	n.a.	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	87.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	540.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	42000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	1.4	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	149300.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	5.58	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	247.67	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	47.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	193.67	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	580.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.23	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	8.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	156.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	4277.67	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	42200.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	60500.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	31.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	89.33	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	55300.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	234.33	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	180.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	76.3	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	13570.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.18	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	595.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	434.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	0.52	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	8.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	106.0	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	2.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	389.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	25670000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	390.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	153.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	1.67	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	15130.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	7.17	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	2.0	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	11870.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	311.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	135.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	138500.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	55.4	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	6.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	673.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	111.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	88.83	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	8.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	306500.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	272.4	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1861.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	5730000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1656.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	93.67	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	200.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	119.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	16.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	62.03	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	63.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	5.03	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	40800.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	185.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	536.83	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	951.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	5050000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	5.0	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	33.23	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	6530000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	64.38	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	102.2	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	27.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	205.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	143.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	125.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	349.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	1.0	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	58.33	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	63.25	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	63.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	96.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	13.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	7.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASO	=	0.4	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	41.83	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	74.43	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	41.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	108.25	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	65.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1710.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	22.48	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	105.75	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	0.67	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	200.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	84.22	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	17.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	0.28	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	9.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	26000000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	2.1	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	36250000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	19.93	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	64.17	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	18.63	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	314500.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	15650.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	63400.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	337.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	20.73	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	42800.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	1527.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	52.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	41.48	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	61000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	36200.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	13940.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	104.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	148.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	72.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.6	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	4.0	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	146.03	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	58.67	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	71.83	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	20.25	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	59.02	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	24.93	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1396670.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	5350000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	733.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	50.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	103.0	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	55700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	125700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	88.67	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	336.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	1.9	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	144.42	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	307.67	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	188.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	183.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	703.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	64.07	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	33.17	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	1.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBCNUC	=	0.33	/100WBC	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	5200000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1576.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	17.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CREAT	=	5.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	156.25	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	65.9	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	152.0	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	76.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.12	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.23	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	471.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	136300.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	19.35	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	123.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	130.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	12.19	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	11.32	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	45.85	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	4600.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.3	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	352.67	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1424670.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	158.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	21.85	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	167.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1240400.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	11.2	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	0.045	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1473250.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.88	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	106.75	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBCNUC	=	0.17	/100WBC	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	136700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.55	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1476750.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	25000000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	390.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	107.75	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1420.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	7340000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	12.9	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	8.83	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	34400.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	0.075	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	12.45	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	102.6	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	28800.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	154200.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	127.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	40.15	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.53	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	306800.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	71.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	23.73	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	64.03	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	122700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASO	=	0.23	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	18.97	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	314.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	117.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	0.042	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	0.025	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	10.8	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	42.82	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	750.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	142.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	87.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	0.48	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	73.24	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	55.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	65.77	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	104.0	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.09	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	378700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	371000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	27000000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	126500.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	14970.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	352.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	0.76	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1512.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	424.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	412.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	20.6	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	313000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	7160000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	132300.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	59.8	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	356.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	10.2	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	108.0	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	338.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	137.4	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1660.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	742.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	0.26	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	2.18	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	41800000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	148.4	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	64.72	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	14.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	0.8	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	475.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	94.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	153.5	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	40250000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	96.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	63300.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	18.74	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	67.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	112.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	37.2	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	103.2	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	23.6	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	12.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	1.75	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1491250.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	7400.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	1220.5	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	88.17	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1266000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	325000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1357.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	112.0	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	271.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	0.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	69.0	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHLORIDE	=	106.25	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1275500.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	7040000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	24900.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	36000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	313300.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	140.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1400000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	379700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOSLE	=	0.67	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	13.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	8.33	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	279.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	143.13	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	75.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	36.77	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	541.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	101.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	16.75	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	279.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	61.35	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	60.7	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	37500000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	36000000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	780.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	46.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	136.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	154.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	3.45	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	2.98	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	18.75	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	600.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	0.0375	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	42.0	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1120000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	6570000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	9.06	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1473.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	66700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	151.25	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	305.4	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	42300.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	95.17	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	13517.17	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BILI	=	2.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	25.9	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASO	=	0.18	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	6610000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	22550.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	10.02	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	45700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	879250.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	267.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	173.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	11170.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	9.25	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	41700.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	757.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	80.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	96.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1314330.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	545.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	EOS	=	24.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	415.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BUN	=	206.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	60000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	686.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	550.33	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	64.33	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	90.0	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	12.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	10947.33	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	1.53	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	6730000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	2.4	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	154.5	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.29	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CK	=	414.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	116.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	32.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1441330.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	39.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	27500000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	143.57	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	49.17	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	18.64	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	1.3	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	383.17	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	33.98	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.52	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	34200.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1537.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTSG	=	1104.67	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	36.85	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	23.17	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	21.25	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	9.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	21.05	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	11.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	63.45	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	117.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	12170.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	813.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	SODIUM	=	143.8	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	116.2	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	317500.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	4570.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	313600.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.37	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.7	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	124000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	70.68	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	WBC	=	19360.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	POTASSIUM	=	6.67	mEq.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	7090000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	50.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	GLUC	=	1534.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONO	=	0.4	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	66.5	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	RBC	=	6640000.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	59.43	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	8.17	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PLAT	=	1307170.0	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	32000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALP	=	320.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASOLE	=	1.05	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	42.27	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	127300.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	73.22	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCV	=	63.1	fL	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	1.73	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	32.8	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	58.8	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PHOS	=	97.4	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	62.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HGB	=	130000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYMLE	=	62.82	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	19.43	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	30.45	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	42.67	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CO2	=	41670000.0	nM	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	626.7	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	10.3	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	18.56	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	CHOL	=	717.5	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	44.28	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LIPASE	=	217.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	13.59	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	2.3	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALB	=	34600.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	PROT	=	64000.0	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MONOLE	=	2.78	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	NEUTLE	=	20.48	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LDH	=	127.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	BASO	=	0.25	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	AST	=	66.0	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	URATE	=	15.2	ug.mL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	LYM	=	9.43	cells.uL-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	43.3	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	ALT	=	42.75	U.L-1	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	HCT	=	42.6	%	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCH	=	20.37	pg	DrugMatrix
NPT29	Organism	Rattus norvegicus	Rattus norvegicus	MCHC	=	315600.0	ug.mL-1	DrugMatrix

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference
Homo sapiens	n.a.	CL	=	24.0	mL.min-1.kg-1	PMID[19445515]
Homo sapiens	Kidney	CL_renal	=	1.8	mL.min-1.kg-1	PMID[19445515]
Homo sapiens	n.a.	Fu	=	0.076	n.a.	PMID[18426954]
n.a.	n.a.	LogP	=	0.2	n.a.	PMID[20106561]
Mus musculus	n.a.	Drug uptake	n.a.	n.a.	n.a.	PMID[24900668]
Canis lupus familiaris	Plasma	AUC	=	305.0	ug.ml-1	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
Mus musculus	n.a.	Drug uptake	=	65.13	%	PMID[24900668]
Mus musculus	n.a.	Drug uptake	=	72.11	%	PMID[24900668]
Homo sapiens	Urine	Compound recovery	=	0.6	%	Therapeutic Drugs
Canis lupus familiaris	Plasma	T1/2	=	0.1	hr	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
Homo sapiens	n.a.	Vdss	=	38.0	L.kg-1	PMID[18426954]
Homo sapiens	n.a.	CL	=	24.0	mL.min-1.kg-1	PMID[18426954]
Homo sapiens	n.a.	T1/2	=	16.0	hr	PMID[18426954]
Canis lupus familiaris	Plasma	Vd	=	34.5	L.kg-1	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
Homo sapiens	Urine	Compound recovery	=	2.0	%	Therapeutic Drugs
Canis lupus familiaris	Plasma	T1/2	=	18.9	hr	FDA drug approval package for Epirubicin (NDA: 21-010 and 50-778)
Homo sapiens	n.a.	MRT	=	26.0	hr	PMID[18426954]

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference
-	Mus musculus	LD50	=	16.0	mg/kg	ToxVal
-	Homo sapiens	DILI_severity_class	=	3.0	n.a.	PMID[26948801]

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC611971 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	9907
0.1-0.2	38826
0.2-0.3	1082
0.3-0.4	26
0.4-0.5	6
0.5-0.6	2
0.6-0.7	2
0.7-0.8	7
0.8-0.85	2
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Natural Product ID
0.8194	Intermediate Similarity	NPC109403
0.8082	Intermediate Similarity	NPC487573
0.7403	Intermediate Similarity	NPC261012
0.7403	Intermediate Similarity	NPC314738
0.7308	Intermediate Similarity	NPC468994
0.726	Intermediate Similarity	NPC602774
0.6883	Remote Similarity	NPC603200
0.6625	Remote Similarity	NPC601855
0.593	Remote Similarity	NPC600087
0.5595	Remote Similarity	NPC603758

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC611971 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	2960
0.1-0.2	6101
0.2-0.3	57
0.3-0.4	2
0.4-0.5	8
0.5-0.6	10
0.6-0.7	1
0.7-0.8	7
0.8-0.85	2
0.85-0.9	0
0.9-0.95	0
0.95-1	2

Similarity Score	Similarity Level	Drug ID	Developmental Stage
1.0	High Similarity	NPD6535	Phase 4
0.9839	High Similarity	NPD6534	Approved
0.8194	Intermediate Similarity	NPD6778	Phase 4
0.8082	Intermediate Similarity	NPD6777	Approved
0.7532	Intermediate Similarity	NPD7699	Phase 2
0.7532	Intermediate Similarity	NPD7700	Phase 2
0.7403	Intermediate Similarity	NPD6781	Phase 4
0.7403	Intermediate Similarity	NPD6782	Phase 4
0.7308	Intermediate Similarity	NPD6779	Approved
0.7308	Intermediate Similarity	NPD6780	Approved
0.7024	Intermediate Similarity	NPD6776	Approved
0.6125	Remote Similarity	NPD7211	Clinical (unspecified phase)
0.5862	Remote Similarity	NPD6823	Phase 2
0.57	Remote Similarity	NPD8058	Clinical (unspecified phase)
0.57	Remote Similarity	NPD8059	Phase 3
0.5484	Remote Similarity	NPD7871	Phase 2
0.5446	Remote Similarity	NPD8155	Clinical (unspecified phase)
0.5426	Remote Similarity	NPD7870	Phase 2
0.5306	Remote Similarity	NPD7801	Approved
0.5263	Remote Similarity	NPD7696	Phase 3
0.5263	Remote Similarity	NPD7697	Phase 3
0.5263	Remote Similarity	NPD7698	Approved

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data