Natural Product Target: Serine/threonine-protein kinase PLK1

Target ID:   NPT831
Target Name:   Serine/threonine-protein kinase PLK1
Target Type:   Individual Protein
Organism of Target:   Homo sapiens
Target External ID:   Uniprot_ID:[ P53350]

  Biological Activities of Natural Products against the Target

Natural Product ID Natural Product Name # Activity Records
NPC98371 Staurosporine 11
NPC469308 Sb-203580 6
NPC333139 Wortmannin 4
NPC56271 Gefitinib 4
NPC476118 Sunitinib 4
NPC470090 Sp-600125 4
NPC471603 Sb-202190 4
NPC180504 A-443654 3
NPC100079 Chelerythrine 2
NPC471579 2
NPC469975 Seliciclib 2
NPC136002 Fascaplysin 2
NPC178134 Ellagic Acid 2
NPC264938 Alvocidib 2
NPC131887 Ro-316233 2
NPC316325 Herbimycin 2
NPC94428 K-252A 2
NPC138978 Altenusin 2
NPC20791 Quercetin 2
NPC204350 Alterlactone 1
NPC232727 Harmine 1
NPC202157 Anomalin A 1
NPC275734 Norlichexanthone 1
NPC142415 Oleanolic_Acid 1
NPC194379 Alternariol 5-O-Sulfate 1
NPC295531 Oxytetracycline 1
NPC188104 n.a. 1
NPC470232 n.a. 1
NPC321402 (8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-Decahydrocyclopenta[A]Phenanthrene-2,3,17-Triol 1
NPC323937 Famotidine 1
NPC475432 Bastadin 3 1
NPC232969 (6As)-5-Chloro-9-[(2R,3R)-3-Hydroxy-2-Methylbutanoyl]-6A-Methyl-3-[(E,3S)-3-Methylpent-1-Enyl]Furo[2,3-H]Isochromene-6,8-Dione 1
NPC101670 4-Hydroxy-3,5-Dimethoxy-4-(2-Oxopropyl)Cyclohexa-2,5-Dien-1-One 1
NPC223836 Desmethylaltenusin 1
NPC277174 5,7-Dihydroxy-3-(3,4,5-Trihydroxy-6-Methyloxan-2-Yl)Oxy-2-(3,4,5-Trihydroxyphenyl)Chromen-4-One 1
NPC143168 Embelin 1
NPC20541 3-Hydroxyalternariol 5-O-Methyl Ether 1
NPC300984 Lobaric Acid 1
NPC189844 Demethoxycurcumin 1
NPC190945 Nifedipine 1
NPC324522 Alterporriol G/H 1
NPC4669 Berberrubine 1
NPC243404 Purpuroine I 1
NPC233267 Diffractaic Acid 1
NPC103250 n.a. 1
NPC469978 Sid14737105 1
NPC277510 Epicoccolide B 1
NPC144682 Butylated Hydroxytoluene 1
NPC301585 Myristic Acid 1
NPC192744 Betunolic Acid 1
NPC63479 Pentachlorophenol 1
NPC325983 Fonsecin 1
NPC5413 Gamolenic Acid 1
NPC280736 Purpuroine A 1
NPC233455 Enoxolone 1
NPC103958 (1R,4As,4Br,7R,10As)-7-Ethenyl-1,4A,7-Trimethyl-3,4,4B,5,6,9,10,10A-Octahydro-2H-Phenanthrene-1-Carboxylic Acid 1
NPC70485 Purpuroine D 1
NPC280026 Lithocholic Acid 1
NPC148163 Perillyl Alcohol 1
NPC31296 24-Exomethylenecalicoferol E 1
NPC304788 Benzoquinone 1
NPC196449 Calcimycin 1
NPC41326 Coumestrol 1
NPC69057 (E)-1,4-Bis(4-Methylphenyl)But-2-Ene-1,4-Dione 1
NPC195902 Purpuroine B 1
NPC238629 Purpurin 1
NPC107109 6-O-Methylalaternin 1
NPC473395 Talaroflavone 1
NPC281398 Tanshinone Iia 1
NPC155444 Ergocryptine 1
NPC258366 Calicoferol A 1
NPC305518 Xanthoxylin 1
NPC197239 Levothyroxine 1
NPC328590 8-Anilinonaphthalene-1-Sulfonic Acid 1
NPC69101 Moronic Acid 1
NPC284810 Daphnorin 1
NPC243509 Pentosalen 1
NPC109083 Curcumin 1
NPC34193 n.a. 1
NPC282294 Ethacrynic Acid 1
NPC155686 Altersolanol A 1
NPC137496 Astrogorgiadiol 1
NPC305602 3-Phenyl-1-Piperidin-1-Ylprop-2-En-1-One 1
NPC202768 n.a. 1
NPC329161 Slazinic Acid 1
NPC72980 Harmalol 1
NPC470951 Sesquibastadin 1 1
NPC245552 [2-Methoxy-4-[(E)-Prop-1-Enyl]Phenyl] Acetate 1
NPC110337 Tritiozine 1
NPC258856 18-Hydroxy-5-Epi-Hyrtiophenol 1
NPC32470 Alternariol 1
NPC166788 Thymoquinone 1
NPC307412 [(8S,9R)-8-(2-Acetyloxypropan-2-Yl)-2-Oxo-8,9-Dihydrofuro[2,3-H]Chromen-9-Yl] (Z)-2-Methylbut-2-Enoate 1
NPC204156 Oxyphenbutazone 1
NPC329416 Isotretinoin 1
NPC73855 Myricitrin 1
NPC247546 1,3,4,5,6-Pentahydroxyhexan-2-One 1
NPC110396 2,6-Dimethoxyquinone 1
NPC209981 5-Epi-Nakijinol C 1
NPC288089 Rhein 1
NPC169749 Myricetin 1
NPC471785 Sid11111800 1
NPC309367 Thiram 1
NPC204617 2,4-Dichlorophenoxyacetic Acid 1
NPC68339 Calicoferol B 1
NPC74562 n.a. 1
NPC79933 Calicoferol E 1
NPC254847 Emodin 1
NPC12305 Gyrophoric Acid 1
NPC471688 n.a. 1
NPC288240 [(3Ar,4S,6Z,9E,11S,11Ar)-11-Hydroxy-6,10-Dimethyl-3-Methylidene-2,8-Dioxo-4,5,11,11A-Tetrahydro-3Ah-Cyclodeca[B]Furan-4-Yl] 2-Methylprop-2-Enoate 1
NPC170018 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 1
NPC313884 n.a. 1
NPC206819 Agroclavine 1
NPC77000 Cryptotanshinone 1
NPC154511 Rel-Astrogorgol F 1
NPC257236 Rottlerin 1
NPC126767 Macrosporin 1
NPC471689 Rac-3-Methoxyepicoccone B 1
NPC288349 2-(Hydroxymethyl)-6-(1H-Indol-3-Yloxy)Oxane-3,4,5-Triol 1
NPC171928 Sesamin 1
NPC40321 Purpuroine H 1
NPC36491 Simvastatin 1
NPC213126 Hyoscyamine 1
NPC84478 Harmaline 1
NPC470709 O-Methyl-N-Trimethyl-3,5-Dibromotyrosine 1
NPC261831 Oleic Acid 1
NPC129578 Rohitukine 1
NPC163846 Amorfrutin A 1
NPC288840 3-[5,7-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxochromen-8-Yl]-5,7-Dihydroxy-2-(4-Hydroxyphenyl)Chromen-4-One 1
NPC85707 Sl-0101 1
NPC314679 12-Methyltetradecanoic Acid 1
NPC216361 Morin 1
NPC92403 Sennoside B 1
NPC44354 Methyl 1-Oxo-2H-Isoquinoline-4-Carboxylate 1
NPC264178 2-Hydroxy-3-[(E)-16-(2-Hydroxy-5-Methoxy-3,6-Dioxocyclohexa-1,4-Dien-1-Yl)Hexadec-8-Enyl]-5-Methoxycyclohexa-2,5-Diene-1,4-Dione 1
NPC130193 (1E,4Z,6E)-5-Hydroxy-1,7-Bis(4-Hydroxyphenyl)Hepta-1,4,6-Trien-3-One 1
NPC469897 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 1
NPC289484 Palmidrol 1
NPC179787 Harman 1
NPC470230 n.a. 1
NPC316052 Erbstatin 1
NPC220705 Sphaeropsidin A 1
NPC187690 Epicoccone B 1
NPC93241 Tanshinone I 1
NPC44830 12-Phenyldodecanoic Acid 1
NPC476440 Tpck 1
NPC290550 Emodic Acid 1
NPC124776 Purpuroine F 1
NPC224270 Sclerotiorin 1
NPC93739 Physodic Acid 1
NPC242945 Kolavenic Acid 1
NPC267509 Alternariol-5-O-Methylether 1
NPC135433 1,6-Dimethylnaphthalene 1
NPC174251 Sid24841469 1
NPC291049 2-Hydroxy-4-(2-Hydroxy-4-Methoxy-3,6-Dimethylbenzoyl)Oxy-3,6-Dimethylbenzoic Acid 1
NPC183503 (1R,4Ar,7R)-7-Ethenyl-1,4A,7-Trimethyl-3,4,4B,5,6,9,10,10A-Octahydro-2H-Phenanthrene-1-Carboxylic Acid 1
NPC85310 Altertoxin I 1
NPC317237 Haematoxylin 1
NPC227396 Prostaglandin B1 1
NPC56634 Purpuroine G 1
NPC31564 7-Oxocholesterol 1
NPC138299 Amentoflavone 1
NPC471690 2,3,4-Trihydroxy-6-(Methoxymethyl)-5-Methylbenzaldehyde 1
NPC294226 Athraquinones A 1
NPC187145 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 1
NPC14098 Alternarienonic Acid 1
NPC317869 (4S,6S,6Ar,9S)-3,6,9-Trimethyl-4-(2-Methylprop-1-Enyl)-5,6,6A,7,8,9-Hexahydro-4H-Phenalene-1,2-Diol 1
NPC227622 Erythromycin 1
NPC142803 Purpuroine C 1
NPC274721 7,11B-Dihydro-6H-Indeno[2,1-C]Chromene-3,6A,9,10-Tetrol 1
NPC247858 Calicoferol C 1
NPC294548 Linolenic Acid 1
NPC269598 Calicoferol I 1
NPC319046 S-Nitrosoglutathione 1

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4. Species Source: species sources that all natural products that have available activity against this target derived from.

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