Natural Product: NPC476118

Natural Product ID:  NPC476118
Common Name:   Sunitinib
IUPAC Name:   N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Synonyms:   SU-11248; Sunitinib; Sutent
Molecular Formula:   C22H27FN4O2
Standard InCHIKey:  WINHZLLDWRZWRT-ATVHPVEESA-N
Standard InCHI:  InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
Canonical SMILES:  CCN(CCN=C(c1c(C)[nH]c(c1C)/C=C/1C(=Nc2c1cc(F)cc2)O)O)CC
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO28718 Penicillium terrestre Species Aspergillaceae Eukaryota PMID[18163588]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 = 172100 nM 22624550
NPT1972 Cell Line GI-ME-N Homo sapiens IC50 = 775148.79 nM 9051910
NPT2123 Cell Line MPP-89 Homo sapiens IC50 = 42058.56 nM PubChem BioAssay data set
NPT2485 Cell Line IA-LM Homo sapiens IC50 = 184193.16 nM 17988097
NPT2399 Cell Line NCI-H2170 Homo sapiens Activity = 0.552 22652254
NPT2075 Cell Line NCI-H2196 Homo sapiens Activity = 0.941 22652254
NPT2411 Cell Line NCI-H2228 Homo sapiens Activity = 0.852 22652254
NPT2 Others Unspecified Activity = 1.032 22652254
NPT2432 Cell Line NCI-H2342 Homo sapiens Activity = 1.026 22652254
NPT2441 Cell Line NCI-H2347 Homo sapiens Activity = 0.748 22652254
NPT2442 Cell Line NCI-H2405 Homo sapiens Activity = 0.796 22652254
NPT2 Others Unspecified Activity = 0.729 22652254
NPT3243 Individual Protein myosin light chain kinase 2 Homo sapiens Kd = 49 nM 23354071
NPT2007 Cell Line NB6 Homo sapiens IC50 = 101286.69 nM 11992775
NPT6483 Individual Protein N-terminal kinase-like protein Mus musculus Activity = 58.2 % 12398531
NPT3206 Individual Protein Serine/threonine-protein kinase Aurora-C Homo sapiens Kd = 220 nM 6195312
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 210 nM 20065051
NPT2070 Cell Line LXF-289 cell line IC50 = 2729.89 nM 19273668
NPT2190 Cell Line GB-1 Homo sapiens IC50 = 710.23 nM 20643902
NPT1967 Cell Line NCI-H526 Homo sapiens IC50 = 1010 nM 20643902
NPT397 Cell Line NCI-H460 Homo sapiens IC50 = 4310 nM 20643902
NPT2 Others Unspecified IC50 = 2670 nM 20643902
NPT2 Others Unspecified IC50 = 5850 nM 20643902
NPT1709 Individual Protein Serine/threonine-protein kinase 17A Homo sapiens Kd = 21 nM 20643902
NPT2164 Cell Line KMS-12-PE Homo sapiens IC50 = 22273.95 nM 23707051
NPT6269 Cell Line NH-6 Homo sapiens Activity = 0.961 23327668
NPT465 Cell Line NCI-N87 Homo sapiens Activity = 1.145 23327668
NPT2 Others Unspecified Activity = 0.952 23327668
NPT2 Others Unspecified Activity = 0.98 15974617
NPT2378 Cell Line NCI-H727 Homo sapiens Activity = 1.041 15974617
NPT2356 Cell Line NCI-H661 Homo sapiens Activity = 1.013 15974617
NPT4610 Cell Line NCI-H838 Homo sapiens Activity = 0.91 18163584
NPT2391 Cell Line NCI-H810 Homo sapiens Activity = 1.079 18163584
NPT3045 Cell Line NUGC-4 Homo sapiens Activity = 1 12141855
NPT2477 Cell Line NUGC-3 Homo sapiens Activity = 0.75 14643343
NPT3319 Individual Protein Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT2033 Cell Line JIYOYE Homo sapiens IC50 = 26274.19 nM 19459694
NPT2082 Cell Line HT-144 Homo sapiens IC50 = 28689.95 nM 24411199
NPT3442 Individual Protein Mitogen-activated protein kinase kinase kinase 7 Homo sapiens Kd = 93 nM 12502310
NPT3265 Individual Protein Casein kinase I isoform alpha-like Homo sapiens Kd = 550 nM 12502310
NPT3441 Individual Protein Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens Kd > 10000 nM 12502310
NPT3440 Individual Protein Dual specificity mitogen-activated protein kinase kinase 5 Homo sapiens Kd = 46 nM 12502310
NPT3439 Individual Protein Homeodomain-interacting protein kinase 4 Homo sapiens Kd = 160 nM 12502310
NPT3301 Individual Protein Eukaryotic translation initiation factor 2-alpha kinase 4 Homo sapiens Kd = 180 nM 17315926
NPT1717 Individual Protein Serine/threonine-protein kinase 25 Homo sapiens Kd = 290 nM 24844534
NPT2 Others Unspecified Activity = 0.912 24844534
NPT370 Cell Line NCI-H23 Homo sapiens Activity = 0.915 24844534
NPT2196 Cell Line NB1 Homo sapiens IC50 = 1961.17 nM 19944611
NPT3327 Individual Protein Mitogen-activated protein kinase kinase kinase 10 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens IC50 > 5000 nM 22608855
NPT3352 Individual Protein Dual specificity testis-specific protein kinase 1 Homo sapiens Kd > 10000 nM 11374948
NPT396 Cell Line T47D Homo sapiens Activity = 0.917 9917283
NPT2424 Cell Line T84 Homo sapiens Activity = 0.84 18507473
NPT2 Others Unspecified Activity = 1.01 18507473
NPT6271 Cell Line TCO-1 Homo sapiens Activity = 0.912 23321561
NPT2 Others Unspecified Activity = 1.013 7775984
NPT1969 Cell Line TGW Homo sapiens Activity = 1.024 12954063
NPT2098 Cell Line EW-18 Homo sapiens IC50 = 1720215.75 nM 7473578
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 20853847
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 21185626
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 21216603
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd = 860 nM 21216603
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 20014752
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd = 2400 nM 20014752
NPT3304 Individual Protein Serine/threonine-protein kinase receptor R3 Homo sapiens Kd > 10000 nM 22194678
NPT2 Others Unspecified IC50 = 13600 nM PubChem BioAssay data set
NPT2403 Cell Line SBC-5 Homo sapiens Activity = 0.992 671464
NPT2 Others Unspecified Activity = 0.98 950644
NPT165 Cell Line HeLa Homo sapiens Activity = 1.003 25626146
NPT165 Cell Line HeLa Homo sapiens Activity = 1.1 26787274
NPT165 Cell Line HeLa Homo sapiens Activity = 1.073 26649766
NPT2 Others Unspecified Activity = 1.112 27060757
NPT6335 Cell Line SCCH-26 Homo sapiens Activity = 1.098 27060757
NPT5348 Cell Line SCaBER Homo sapiens Activity = 0.917 27060757
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 1200 nM 26896705
NPT2040 Cell Line P30-OHK Homo sapiens IC50 = 151373 nM 17958396
NPT3364 Individual Protein Protein kinase C mu Homo sapiens Kd = 310 nM 17958396
NPT1698 Individual Protein Serine/threonine-protein kinase PCTAIRE-1 Homo sapiens Kd = 130 nM 17958396
NPT3224 Individual Protein Phosphorylase kinase gamma subunit 1 Homo sapiens Kd = 70 nM 17958396
NPT3243 Individual Protein myosin light chain kinase 2 Homo sapiens Kd = 57 nM 17958396
NPT3239 Individual Protein Nerve growth factor receptor Trk-A Homo sapiens Kd = 220 nM 17939738
NPT1658 Individual Protein Serine/threonine-protein kinase NEK2 Homo sapiens Kd = 500 nM 17939738
NPT3254 Individual Protein Ribosomal protein S6 kinase alpha 6 Homo sapiens Kd = 2400 nM PubChem BioAssay data set
NPT2012 Cell Line NCI-H720 Homo sapiens IC50 = 231837.57 nM 13678412
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 870 nM 22608855
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 4510 nM 24370010
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 18900 nM PubChem BioAssay data set
NPT1998 Cell Line RS4-11 Homo sapiens IC50 = 2179.24 nM PubChem BioAssay data set
NPT2193 Cell Line IM-9 Homo sapiens IC50 = 1678948.53 nM 10.1016/j.cropro.2006.02.001
NPT281 Individual Protein MAP kinase ERK1 Homo sapiens Kd > 10000 nM 10.1016/j.cropro.2012.04.001
NPT2138 Cell Line MSTO-211H Homo sapiens IC50 = 31867.8 nM 10.1016/j.cropro.2012.04.001
NPT1958 Cell Line A388 Homo sapiens IC50 = 28007.35 nM 10.1016/j.cropro.2007.04.007
NPT384 Cell Line TK-10 Homo sapiens IC50 = 30126.01 nM 10.3390/molecules16075618
NPT2459 Cell Line HCC70 Homo sapiens Activity = 1.143 15161186
NPT466 Cell Line U-937 Homo sapiens IC50 > 5000 nM PubChem BioAssay data set
NPT2162 Cell Line HCE-T Homo sapiens IC50 = 556276.24 nM PubChem BioAssay data set
NPT3311 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens Kd = 180 nM 18293924
NPT2081 Cell Line HCC1599 Homo sapiens IC50 = 8199.87 nM 12662097
NPT2175 Cell Line GAK Homo sapiens IC50 = 64656.78 nM 12502319
NPT3226 Individual Protein Casein kinase I epsilon Homo sapiens Kd = 13 nM 22574670
NPT1684 Individual Protein Casein kinase I gamma 1 Homo sapiens Kd = 930 nM 22574670
NPT1721 Individual Protein Death-associated protein kinase 1 Homo sapiens Kd = 120 nM 22574670
NPT3236 Individual Protein Death-associated protein kinase 2 Homo sapiens Kd = 150 nM 22574670
NPT3273 Individual Protein Casein kinase II alpha (prime) Homo sapiens Kd = 370 nM 22574670
NPT1687 Individual Protein Death-associated protein kinase 3 Homo sapiens Kd = 22 nM 22574670
NPT3335 Individual Protein Serine/threonine-protein kinase DCLK1 Homo sapiens Kd = 370 nM 22574670
NPT2348 Cell Line HLE Homo sapiens Activity = 0.945 25651042
NPT2 Others Unspecified Activity = 1.077 25651042
NPT2511 Cell Line HGC-27 Homo sapiens Activity = 0.751 20408555
NPT307 Cell Line HOS Homo sapiens Activity = 0.987 20408555
NPT2 Others Unspecified Activity = 1.054 18284207
NPT2 Others Unspecified Activity = 0.833 22206869
NPT98 Individual Protein HERG Homo sapiens IC50 = 251.19 nM 18081254
NPT2204 Cell Line HH Homo sapiens IC50 = 4209.14 nM 22472691
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens Kd = 12 nM 22472691
NPT3322 Individual Protein PITSLRE serine/threonine-protein kinase CDC2L2 Homo sapiens Kd > 10000 nM 21899267
NPT3424 Individual Protein Microtubule-associated serine/threonine-protein kinase 1 Homo sapiens Kd = 200 nM 26042639
NPT3280 Individual Protein Serine/threonine-protein kinase c-TAK1 Homo sapiens Kd = 410 nM 26042639
NPT3235 Individual Protein MAP/microtubule affinity-regulating kinase 2 Homo sapiens Kd = 310 nM 18232640
NPT3109 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens Kd = 41 nM 18081255
NPT1690 Individual Protein Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens Kd = 110 nM 18081255
NPT3448 Individual Protein Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens IC50 = 15 nM 10.1016/0960-894X(96)00096-0
NPT2041 Cell Line P31-FUJ Homo sapiens IC50 = 1224725.48 nM 13678412
NPT639 Cell Line NCI-H187 Homo sapiens IC50 = 231956.07 nM 17480098
NPT65 Cell Line HepG2 Homo sapiens IC50 = 3810 nM 17480098
NPT407 Cell Line COLO 205 Homo sapiens IC50 > 4000 nM 17880175
NPT116 Cell Line HL-60 Homo sapiens IC50 = 3530 nM PubChem BioAssay data set
NPT3264 Individual Protein Serine/threonine-protein kinase RIO1 Homo sapiens Kd = 35 nM 16124780
NPT3217 Individual Protein Ephrin type-A receptor 3 Homo sapiens Kd = 2100 nM 18986200
NPT858 Cell Line LNCaP Homo sapiens IC50 = 12610 nM 3210015
NPT1436 Individual Protein Focal adhesion kinase 1 Homo sapiens Kd = 610 nM 26214125
NPT3336 Individual Protein Serine/threonine-protein kinase DCLK2 Homo sapiens Kd = 2700 nM 22401866
NPT3274 Individual Protein Dual specificity tyrosine-phosphorylation-regulated kinase 1B Homo sapiens Kd = 2300 nM 22401866
NPT2 Others Unspecified Kd = 6800 nM 22401866
NPT737 Cell Line HUVEC Homo sapiens IC90 = 1000 nM 18163592
NPT3274 Individual Protein Dual specificity tyrosine-phosphorylation-regulated kinase 1B Homo sapiens Kd = 2300 nM 10514324
NPT3293 Individual Protein Activin receptor type-1B Homo sapiens Kd > 10000 nM 19193024
NPT394 Cell Line EKVX Homo sapiens IC50 = 1061717.33 nM 17958396
NPT1449 Individual Protein Tyrosine-protein kinase SYK Homo sapiens Kd > 10000 nM 17958396
NPT1613 Individual Protein Ribosomal protein S6 kinase alpha 5 Homo sapiens Kd = 28 nM 17958396
NPT1999 Cell Line TUR Homo sapiens IC50 = 1053110.03 nM 21982797
NPT13 Individual Protein Tyrosine-protein kinase LCK Homo sapiens Kd = 230 nM 20402524
NPT139 Cell Line HT-29 Homo sapiens GI < 10 % 20155971
NPT3303 Individual Protein Discoidin domain-containing receptor 2 Homo sapiens Kd > 10000 nM 19572611
NPT405 Cell Line NCI-H226 Homo sapiens IC50 = 139254.61 nM 8350094
NPT2153 Cell Line RH-1 Homo sapiens IC50 = 187317.12 nM 16279782
NPT3450 Individual Protein Putative uncharacterized serine/threonine-protein kinase SgK110 Homo sapiens Kd = 1900 nM 18327911
NPT3449 Individual Protein Wee1-like protein kinase 2 Homo sapiens Kd > 10000 nM 18327911
NPT1656 Individual Protein Protein kinase N1 Homo sapiens Kd = 710 nM 18327911
NPT3259 Individual Protein Tyrosine-protein kinase ZAP-70 Homo sapiens Kd > 10000 nM 18327911
NPT3452 Individual Protein Calcium-dependent protein kinase 1 Plasmodium falciparum (isolate 3D7) Kd = 1300 nM 18327911
NPT3451 Individual Protein Dual serine/threonine and tyrosine protein kinase Homo sapiens Kd = 1300 nM 18327911
NPT2 Others Unspecified Activity = 0.939 19734910
NPT2 Others Unspecified Activity = 0.676 19734910
NPT369 Cell Line ACHN Homo sapiens Activity = 0.811 PubChem BioAssay data set
NPT2281 Cell Line ABC-1 Homo sapiens Activity = 1.025 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.974 PubChem BioAssay data set
NPT196 Cell Line AGS Homo sapiens Activity = 1.175 PubChem BioAssay data set
NPT2296 Cell Line AU565 Homo sapiens Activity = 1.244 PubChem BioAssay data set
NPT2297 Cell Line ASPC1 Homo sapiens Activity = 1.046 18809934
NPT2313 Cell Line BCPAP Homo sapiens Activity = 0.814 18809934
NPT2 Others Unspecified Activity = 1.157 18809934
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.28 nM PubChem BioAssay data set
NPT3356 Individual Protein Tyrosine-protein kinase receptor Tie-1 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT2113 Cell Line EW-24 Homo sapiens IC50 = 547608.71 nM 18442289
NPT3335 Individual Protein Serine/threonine-protein kinase DCLK1 Homo sapiens Kd = 370 nM 20141173
NPT3221 Individual Protein Serine/threonine-protein kinase GAK Homo sapiens Kd = 120 nM 17253840
NPT2 Others Unspecified GI50 = 1100 nM 17253840
NPT2 Others Unspecified GI50 = 1200 nM 17253840
NPT2178 Cell Line KNS-81-FD Homo sapiens IC50 = 850390.79 nM 15787442
NPT1082 Cell Line NCI-H2126 Homo sapiens IC50 = 104941.07 nM 15620246
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Inhibition = 89.7 % 12398547
NPT139 Cell Line HT-29 Homo sapiens IC50 = 1470 nM 15165156
NPT2063 Cell Line SK-PN-DW Homo sapiens IC50 = 8609.85 nM 23410078
NPT3267 Individual Protein Macrophage colony stimulating factor receptor Homo sapiens Kd = 2 nM 22940450
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens IC50 = 1300 nM 8411013
NPT83 Cell Line MCF7 Homo sapiens IC50 = 25410 nM 8411013
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens IC50 = 220 nM 19489598
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 18900 nM 10514300
NPT1630 Individual Protein CaM kinase II beta Homo sapiens Kd = 1400 nM 24128115
NPT3310 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens Kd = 16 nM 16441059
NPT2169 Cell Line MZ7-mel Homo sapiens IC50 = 59766.18 nM 22946634
NPT2 Others Unspecified IC50 = 8000 nM 21036050
NPT2 Others Unspecified FC = 0.77 21036050
NPT2 Others Unspecified IC50 = 504 nM 20337486
NPT2053 Cell Line LU-139 Homo sapiens IC50 = 264810.11 nM 17477572
NPT2044 Cell Line SW 962 Homo sapiens IC50 = 20429.26 nM 14640526
NPT2 Others Unspecified Ratio IC50 > 7.7 19105653
NPT2 Others Unspecified IC50 > 1000 nM 19105653
NPT146 Cell Line SK-OV-3 Homo sapiens IC50 = 9210 nM 10698435
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens IC50 > 50000 nM 17417631
NPT2046 Cell Line EVSA-T Homo sapiens Activity = 1.017 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 1.076 PubChem BioAssay data set
NPT2272 Cell Line EFM-19 Homo sapiens Activity = 1.06 19651911
NPT2 Others Unspecified Activity = 1.108 21261296
NPT2 Others Unspecified Activity = 1.154 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 1.176 PubChem BioAssay data set
NPT2273 Cell Line EFO-21 Homo sapiens Activity = 0.994 PubChem BioAssay data set
NPT2275 Cell Line EGI-1 Homo sapiens Activity = 1.094 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.933 PubChem BioAssay data set
NPT2269 Cell Line EPLC-272H Homo sapiens Activity = 0.857 PubChem BioAssay data set
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 2.4 nM PubChem BioAssay data set
NPT1656 Individual Protein Protein kinase N1 Homo sapiens Kd = 710 nM PubChem BioAssay data set
NPT1702 Individual Protein Serine/threonine-protein kinase PLK4 Homo sapiens Kd = 190 nM PubChem BioAssay data set
NPT3223 Individual Protein Phosphorylase kinase gamma subunit 2 Homo sapiens Kd = 5.9 nM PubChem BioAssay data set
NPT3260 Individual Protein Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Homo sapiens Kd = 39 nM PubChem BioAssay data set
NPT3252 Individual Protein Serine/threonine-protein kinase PFTAIRE-1 Homo sapiens Kd = 270 nM 22386564
NPT3245 Individual Protein Tyrosine kinase non-receptor protein 2 Homo sapiens Kd = 8900 nM PubChem BioAssay data set
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens Kd > 10000 nM 17451272
NPT1709 Individual Protein Serine/threonine-protein kinase 17A Homo sapiens Kd = 1 nM 10217738
NPT1481 Individual Protein Fibroblast growth factor receptor 2 Homo sapiens Kd = 570 nM 22264170
NPT1941 Cell Line A101D Homo sapiens IC50 = 2783.04 nM 12880315
NPT3112 Individual Protein Tyrosine-protein kinase FGR Homo sapiens Kd = 290 nM 22686608
NPT737 Cell Line HUVEC Homo sapiens IC50 = 3900 nM 26420067
NPT2167 Cell Line LB996-RCC Homo sapiens IC50 = 4121.68 nM 18247573
NPT189 Cell Line Vero Chlorocebus aethiops GI < 10 % 18829331
NPT833 Individual Protein Tyrosine-protein kinase BTK Homo sapiens Kd > 10000 nM 17190444
NPT3321 Individual Protein PITSLRE serine/threonine-protein kinase CDC2L1 Homo sapiens Kd > 10000 nM 17190444
NPT1434 Individual Protein Serine/threonine-protein kinase B-raf Homo sapiens Kd > 10000 nM 17190444
NPT1431 Individual Protein Mitogen-activated protein kinase kinase kinase 5 Homo sapiens Kd > 10000 nM 17190444
NPT3407 Individual Protein Mitogen-activated protein kinase kinase kinase 6 Homo sapiens Kd > 10000 nM 17190444
NPT3313 Individual Protein Bone morphogenetic protein receptor type-1A Homo sapiens Kd > 10000 nM 17190444
NPT3385 Individual Protein Bone morphogenetic protein receptor type-1B Homo sapiens Kd > 10000 nM 17190444
NPT2027 Cell Line SK-N-DZ Homo sapiens IC50 = 4670.99 nM 17190444
NPT65 Cell Line HepG2 Homo sapiens IC50 = 15400 nM 17190444
NPT3227 Individual Protein Fibroblast growth factor receptor 3 Homo sapiens Kd = 290 nM 17190444
NPT2573 Individual Protein Vascular endothelial growth factor receptor 3 Homo sapiens Kd = 35 nM 18847246
NPT36 Individual Protein Tyrosine-protein kinase SRC Homo sapiens Kd = 3100 nM 12852746
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Inhibition = 94.2 % 17665898
NPT2183 Cell Line NCI-H1694 Homo sapiens IC50 = 13114.4 nM 17665898
NPT2117 Cell Line HuTu80 Homo sapiens IC50 = 13757.26 nM 21907579
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 18900 nM 24900715
NPT2119 Cell Line KINGS-1 Homo sapiens IC50 = 102588.21 nM 12061875
NPT2140 Cell Line NOMO-1 Homo sapiens IC50 = 4336.99 nM 7562925
NPT2163 Cell Line KMOE-2 Homo sapiens IC50 = 8194.2 nM 11495582
NPT1935 Cell Line BB65-RCC Homo sapiens IC50 = 18416.21 nM 12930139
NPT550 Cell Line T-24 Homo sapiens Activity = 1.059 10969993
NPT3388 Individual Protein Tyrosine-protein kinase CTK Homo sapiens Kd > 10000 nM 10969993
NPT3113 Individual Protein Tyrosine-protein kinase CSK Homo sapiens Kd > 10000 nM 10969993
NPT1688 Individual Protein Myotonin-protein kinase Homo sapiens Kd > 10000 nM 10969993
NPT3303 Individual Protein Discoidin domain-containing receptor 2 Homo sapiens Kd > 10000 nM 1495014
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 1495014
NPT2 Others Unspecified Kd > 10000 nM 1495014
NPT2 Others Unspecified Activity = 1.034 1495014
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens Kd = 13 nM 10782668
NPT2090 Cell Line SNU-16 Homo sapiens IC50 = 1464.86 nM 17079152
NPT98 Individual Protein HERG Homo sapiens IC50 = 7943.28 nM 17360571
NPT1695 Individual Protein Serine/threonine-protein kinase PAK 4 Homo sapiens Kd = 2300 nM 17502416
NPT2388 Cell Line LU-135 Homo sapiens Activity = 1.055 17502416
NPT2 Others Unspecified Activity = 1.052 17502416
NPT2 Others Unspecified Activity = 0.989 17502416
NPT4246 Cell Line LS174T Homo sapiens Activity = 0.976 17502416
NPT114 Cell Line LoVo Homo sapiens Activity = 0.693 17502416
NPT2 Others Unspecified Activity = 0.956 17502416
NPT2 Others Unspecified Activity = 1.305 17502416
NPT2 Others Unspecified Activity = 0.864 17502416
NPT2 Others Unspecified Activity = 0.981 17502416
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 55 nM 11975502
NPT3267 Individual Protein Macrophage colony stimulating factor receptor Homo sapiens IC50 = 35 nM 11975502
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 38 nM 11975502
NPT1970 Cell Line THP-1 Homo sapiens IC50 = 191743.4 nM 19914077
NPT2 Others Unspecified Kd = 0.28 nM 20568782
NPT392 Cell Line SNB-75 Homo sapiens IC50 = 127392.26 nM 20630628
NPT2097 Cell Line EW-16 Homo sapiens IC50 = 2135.08 nM 20739103
NPT2390 Cell Line NCI-H2122 Homo sapiens Activity = 0.888 18694951
NPT2 Others Unspecified IC50 = 100 nM 18694952
NPT139 Cell Line HT-29 Homo sapiens IC50 = 330 nM 18694952
NPT6374 Cell Line BaF3 Mus musculus GI50 = 2780 nM 20708825
NPT4149 Protein Complex Gamma-secretase Homo sapiens Inhibition = 26 % 18458131
NPT204 Individual Protein Acetylcholinesterase Homo sapiens IC50 = 5870 nM 19223627
NPT1702 Individual Protein Serine/threonine-protein kinase PLK4 Homo sapiens Kd = 380 nM 20350944
NPT6462 Cell Line VMRC-MELG Homo sapiens Activity = 1 20733039
NPT2435 Cell Line VM-CUB-1 Homo sapiens Activity = 0.981 20733039
NPT2 Others Unspecified Activity = 0.996 20733039
NPT6424 Cell Line VMRC-LCP Homo sapiens Activity = 1.04 20733039
NPT2 Others Unspecified Activity = 0.54 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.892 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.837 PubChem BioAssay data set
NPT4649 Cell Line KHOS/NP Homo sapiens Activity = 0.899 PubChem BioAssay data set
NPT2133 Cell Line KM-H2 Homo sapiens Activity = 1.272 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.697 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.806 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 1.236 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.991 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 1.059 PubChem BioAssay data set
NPT2 Others Unspecified Kd = 380 nM Casarett and Doull's Toxicology The Basic Science of Poisons, 7th edition
NPT2 Others Unspecified Kd = 2.2 nM Casarett and Doull's Toxicology The Basic Science of Poisons, 7th edition
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 890 nM 21481593
NPT2198 Cell Line NCI-H524 Homo sapiens IC50 = 58569.55 nM 21770434
NPT3220 Individual Protein Ephrin type-A receptor 6 Homo sapiens Kd = 960 nM DrugMatrix in vitro pharmacology data
NPT3231 Individual Protein Dual specificity protein kinase CLK4 Homo sapiens Kd = 29 nM DrugMatrix in vitro pharmacology data
NPT1672 Individual Protein CaM kinase I delta Homo sapiens Kd = 1100 nM 22133458
NPT65 Cell Line HepG2 Homo sapiens Activity = 5 % 10.1007/s00044-011-9605-5
NPT1215 Cell Line 8505C Homo sapiens Activity = 0.905 20118573
NPT2112 Cell Line TE-1 Homo sapiens IC50 = 20410.37 nM 20118573
NPT179 Cell Line A2780 Homo sapiens Activity = 1.001 15161186
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens IC50 = 13.1 nM 15161186
NPT1083 Cell Line A-375 Homo sapiens Activity = 1.051 15161186
NPT762 Cell Line A-431 Homo sapiens Activity = 0.986 10.1007/s00044-012-0026-x
NPT81 Cell Line A549 Homo sapiens Activity = 0.812 10.1007/s00044-012-0026-x
NPT2066 Cell Line EW-11 Homo sapiens IC50 = 34472.54 nM Open TG-GATES in vivo data: Hematology
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Hematology
NPT3124 Individual Protein Protein kinase C eta Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Pathology
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 9 nM Open TG-GATES in vivo data: Organ Weight
NPT659 Cell Line SMMC-7721 Homo sapiens IC50 = 6470 nM Open TG-GATES in vivo data: Biochemistry
NPT862 Individual Protein Epoxide hydratase Homo sapiens IC50 > 10000 nM Open TG-GATES in vivo data: Biochemistry
NPT3313 Individual Protein Bone morphogenetic protein receptor type-1A Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Biochemistry
NPT32 Organism Mus musculus Mus musculus Activity = -24.1 % Open TG-GATES in vivo data: Biochemistry
NPT301 Individual Protein Vascular endothelial growth factor receptor 1 Homo sapiens Ki = 2 nM Open TG-GATES in vivo data: Biochemistry
NPT2 Others Unspecified IC50 = 3 nM Open TG-GATES in vivo data: Biochemistry
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Ki = 4 nM Open TG-GATES in vivo data: Biochemistry
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Ki = 8 nM Open TG-GATES in vivo data: Biochemistry
NPT1687 Individual Protein Death-associated protein kinase 3 Homo sapiens Kd = 300 nM Open TG-GATES in vivo data: Biochemistry
NPT2151 Cell Line NCI-H345 Homo sapiens IC50 = 295123.82 nM Open TG-GATES in vivo data: Biochemistry
NPT2 Others Unspecified Activity = 0.89 Open TG-GATES in vivo data: Biochemistry
NPT3792 Cell Line 143B Homo sapiens Activity = 0.909 Open TG-GATES in vivo data: Biochemistry
NPT2295 Cell Line 5637 Homo sapiens Activity = 1.184 Open TG-GATES in vivo data: Biochemistry
NPT2 Others Unspecified Activity = 0.979 Open TG-GATES in vivo data: Biochemistry
NPT1432 Individual Protein Serine/threonine-protein kinase Aurora-A Homo sapiens Kd = 6600 nM Open TG-GATES in vivo data: Biochemistry
NPT737 Cell Line HUVEC Homo sapiens IC50 = 4040 nM DrugMatrix in vivo data: Pathology
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 15 nM DrugMatrix in vivo data: Pathology
NPT3210 Individual Protein BMP-2-inducible protein kinase Homo sapiens Kd = 38 nM DrugMatrix in vivo data: Pathology
NPT2 Others Unspecified Kd = 2800 nM DrugMatrix in vivo data: Pathology
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 830 nM DrugMatrix in vivo data: Pathology
NPT3228 Individual Protein Adaptor-associated kinase Homo sapiens Kd = 11 nM DrugMatrix in vivo data: Pathology
NPT5519 Cell Line SBC-3 Homo sapiens Activity = 1.075 DrugMatrix in vivo data: Pathology
NPT165 Cell Line HeLa Homo sapiens Activity = 1.072 DrugMatrix in vivo data: Pathology
NPT833 Individual Protein Tyrosine-protein kinase BTK Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Biochemistry
NPT3248 Individual Protein CaM-kinase kinase alpha Homo sapiens Kd = 900 nM DrugMatrix in vivo data: Hematology
NPT14 Individual Protein Tyrosine-protein kinase FYN Homo sapiens Kd = 520 nM 25576739
NPT2473 Cell Line MDA-MB-361 Homo sapiens Activity = 1.364 26209266
NPT2 Others Unspecified Activity = 0.892 10411485
NPT2 Others Unspecified Activity = 0.917 9822558
NPT2504 Cell Line NCI-H1755 Homo sapiens Activity = 0.957 9822558
NPT2 Others Unspecified Activity = 0.936 9822558
NPT1669 Cell Line NCI-H1792 Homo sapiens Activity = 0.886 9822558
NPT2334 Cell Line NCI-H1793 Homo sapiens Activity = 0.812 9822558
NPT2475 Cell Line NCI-H1651 Homo sapiens Activity = 0.91 9822558
NPT2491 Cell Line NCI-H1693 Homo sapiens Activity = 0.873 9822558
NPT4618 Cell Line NCI-H1734 Homo sapiens Activity = 1.046 9822558
NPT1675 Individual Protein CaM kinase II delta Homo sapiens Kd = 420 nM 10785421
NPT1676 Individual Protein CaM kinase II gamma Homo sapiens Kd = 690 nM 10785421
NPT1677 Individual Protein CaM kinase IV Homo sapiens Kd = 890 nM 10785421
NPT3248 Individual Protein CaM-kinase kinase alpha Homo sapiens Kd = 420 nM 10785421
NPT395 Cell Line SF-268 Homo sapiens IC50 = 3328.69 nM 26331426
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Inhibition = 76 % 19260658
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Inhibition = 100 % PubChem BioAssay data set
NPT676 Individual Protein Glycogen synthase kinase-3 alpha Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT1697 Individual Protein Serine/threonine-protein kinase PAK6 Homo sapiens Kd = 2400 nM PubChem BioAssay data set
NPT3300 Individual Protein Serine/threonine-protein kinase 32B Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT3317 Individual Protein Serine/threonine-protein kinase MARK1 Homo sapiens Kd = 1200 nM PubChem BioAssay data set
NPT3429 Individual Protein SNF-related serine/threonine-protein kinase Homo sapiens Kd = 640 nM PubChem BioAssay data set
NPT1704 Individual Protein Serine/threonine-protein kinase RIO2 Homo sapiens Kd = 49 nM PubChem BioAssay data set
NPT3428 Individual Protein Transient receptor potential cation channel subfamily M member 6 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT3306 Individual Protein Serine/threonine-protein kinase MRCK gamma Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT3213 Individual Protein MAP kinase signal-integrating kinase 2 Homo sapiens Kd = 5700 nM PubChem BioAssay data set
NPT2118 Cell Line KGN Homo sapiens IC50 = 2603.39 nM 8277308
NPT1438 Individual Protein Insulin-like growth factor I receptor Homo sapiens Kd = 2600 nM 8277308
NPT65 Cell Line HepG2 Homo sapiens Activity > 75 % 23634786
NPT2339 Cell Line TGBC24TKB Homo sapiens IC50 = 160923.65 nM 22401866
NPT5890 Protein Complex Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) Homo sapiens IC50 = 63095.73 nM 23354072
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Kd = 1.5 nM 19327990
NPT3398 Individual Protein Serine/threonine-protein kinase ULK1 Homo sapiens Kd = 23 nM 9868162
NPT3277 Individual Protein Tyrosine-protein kinase receptor TYRO3 Homo sapiens Kd = 49 nM 8984155
NPT3382 Individual Protein Serine/threonine-protein kinase ULK3 Homo sapiens Kd = 42 nM 8984155
NPT3422 Individual Protein Serine/threonine-protein kinase ULK2 Homo sapiens Kd = 13 nM 8984155
NPT3270 Individual Protein Neurotrophic tyrosine kinase receptor type 2 Homo sapiens Kd = 590 nM 8984155
NPT3276 Individual Protein Tyrosine-protein kinase TYK2 Homo sapiens Kd = 360 nM 8984155
NPT3238 Individual Protein Dual specificity protein kinase TTK Homo sapiens Kd = 63 nM 8984155
NPT2201 Cell Line SK-LMS-1 Homo sapiens IC50 = 3833.38 nM 22934671
NPT2 Others Unspecified Survival = 9.8 % 17685651
NPT1984 Cell Line ONS-76 Homo sapiens IC50 = 9810.16 nM 17958396
NPT1691 Individual Protein Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens Kd = 5200 nM 16989540
NPT1614 Individual Protein MAP kinase p38 delta Homo sapiens Kd > 10000 nM 24547794
NPT2093 Cell Line PF-382 Homo sapiens IC50 = 3445.7 nM 7623047
NPT369 Cell Line ACHN Homo sapiens IC50 = 5700 nM 12617583
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 140 nM 16252909
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 380 nM 16180824
NPT2 Others Unspecified IC50 = 8 nM 25314007
NPT1930 Cell Line CTB-1 Homo sapiens IC50 = 13729.43 nM 26848627
NPT2004 Cell Line LS-123 Homo sapiens IC50 = 9681.61 nM 25237727
NPT197 Protein-Protein Interaction Menin/Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 6309.6 nM PubChem BioAssay data set
NPT3204 Individual Protein Tyrosine-protein kinase FRK Homo sapiens Kd = 530 nM 22731892
NPT3244 Individual Protein Tyrosine-protein kinase FER Homo sapiens Kd = 1400 nM 18951805
NPT3347 Individual Protein Cyclin-dependent kinase 9 Homo sapiens Kd > 10000 nM 18951805
NPT1608 Individual Protein Serine/threonine-protein kinase Chk1 Homo sapiens Kd = 300 nM 18951805
NPT3314 Individual Protein Bone morphogenetic protein receptor type-2 Homo sapiens Kd = 570 nM 18951805
NPT1630 Individual Protein CaM kinase II beta Homo sapiens Kd = 1400 nM 25871261
NPT3345 Individual Protein Cyclin-dependent kinase 3 Homo sapiens Kd > 10000 nM 25871261
NPT3324 Individual Protein Cell division protein kinase 8 Homo sapiens Kd > 10000 nM 25871261
NPT3384 Individual Protein Cyclin-dependent kinase-like 3 Homo sapiens Kd > 10000 nM 25871261
NPT3283 Individual Protein MAP kinase-interacting serine/threonine-protein kinase MNK1 Homo sapiens Kd = 3900 nM 25871261
NPT3253 Individual Protein Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Homo sapiens Kd = 5400 nM 10075755
NPT3385 Individual Protein Bone morphogenetic protein receptor type-1B Homo sapiens Kd = 2400 nM 10075755
NPT1953 Cell Line D-336MG Homo sapiens IC50 = 292957.93 nM 16933872
NPT3239 Individual Protein Nerve growth factor receptor Trk-A Homo sapiens Kd = 220 nM 20666364
NPT2 Others Unspecified Activity = 1.218 15104492
NPT3372 Individual Protein Fibroblast growth factor receptor 4 Homo sapiens Kd > 10000 nM 25747495
NPT676 Individual Protein Glycogen synthase kinase-3 alpha Homo sapiens Kd > 10000 nM 25747495
NPT3362 Individual Protein Mitogen-activated protein kinase 7 Homo sapiens Kd > 10000 nM 25747495
NPT3363 Individual Protein Mitogen-activated protein kinase 15 Homo sapiens Kd > 10000 nM 25747495
NPT981 Individual Protein Inhibitor of nuclear factor kappa B kinase beta subunit Homo sapiens Kd > 10000 nM 25747495
NPT1426 Individual Protein c-Jun N-terminal kinase 1 Homo sapiens Kd > 10000 nM 25747495
NPT591 Individual Protein Glycogen synthase kinase-3 beta Homo sapiens Kd > 10000 nM 25747495
NPT3444 Individual Protein Homeodomain-interacting protein kinase 1 Homo sapiens Kd > 10000 nM 25747495
NPT1427 Individual Protein c-Jun N-terminal kinase 2 Homo sapiens Kd > 10000 nM 25747495
NPT3207 Individual Protein c-Jun N-terminal kinase 3 Homo sapiens Kd > 10000 nM 25747495
NPT3223 Individual Protein Phosphorylase kinase gamma subunit 2 Homo sapiens Kd = 5.9 nM 24224794
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 530 nM 20423106
NPT1708 Individual Protein Serine/threonine-protein kinase 16 Homo sapiens Kd = 250 nM 20423106
NPT2941 Individual Protein Ephrin type-B receptor 2 Homo sapiens Kd > 10000 nM 21910504
NPT4149 Protein Complex Gamma-secretase Homo sapiens Inhibition = 53 % 12932139
NPT2 Others Unspecified IC50 = 19930 nM 12444699
NPT32 Organism Mus musculus Mus musculus Activity = 12.3 % 19926279
NPT2146 Cell Line YT Homo sapiens IC50 = 193369.91 nM PubChem BioAssay data set
NPT80 Cell Line Raji Homo sapiens IC50 = 19956.54 nM 21504145
NPT5182 Cell Line OV-1063 Homo sapiens Activity = 0.858 23734721
NPT382 Cell Line OVCAR-5 Homo sapiens Activity = 1.092 23734721
NPT2479 Cell Line OAW-28 Homo sapiens Activity = 0.951 17608532
NPT2492 Cell Line OAW-42 Homo sapiens Activity = 0.926 23734701
NPT2336 Cell Line OE19 Homo sapiens Activity = 1.055 23734701
NPT2 Others Unspecified Activity = 0.965 23734701
NPT2337 Cell Line OE33 Homo sapiens Activity = 1.069 23734701
NPT2 Others Unspecified Activity = 0.859 23734701
NPT2 Others Unspecified Activity = 1.168 23734701
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Activity = 73 % 23734701
NPT3901 Tissue Chorioallantoic membrane Gallus gallus IC50 = 1300 nM 10978216
NPT2172 Cell Line SIMA Homo sapiens IC50 = 316661.06 nM 15104485
NPT3358 Individual Protein Serine/threonine-protein kinase PLK3 Homo sapiens Kd > 10000 nM 1707976
NPT2448 Cell Line KLE Homo sapiens IC50 = 29619.03 nM 7143358
NPT2135 Cell Line LB373-MEL-D Homo sapiens IC50 = 540755.91 nM 7143358
NPT2024 Cell Line NCI-H209 Homo sapiens IC50 = 8116.52 nM 20739103
NPT3371 Individual Protein Receptor-interacting serine/threonine-protein kinase 1 Homo sapiens Kd = 370 nM 16472241
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens IC50 = 8 nM DrugMatrix in vitro pharmacology data
NPT83 Cell Line MCF7 Homo sapiens IC50 = 23760 nM DrugMatrix in vitro pharmacology data
NPT623 Cell Line NALM-6 Homo sapiens IC50 = 2904.73 nM DrugMatrix in vitro pharmacology data
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 7400 nM DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified Activity = 0.943 DrugMatrix in vivo data: Pathology
NPT2371 Cell Line SW837 Homo sapiens Activity = 1.033 DrugMatrix in vivo data: Pathology
NPT2361 Cell Line SW780 Homo sapiens Activity = 0.892 DrugMatrix in vivo data: Pathology
NPT2338 Cell Line SW48 Homo sapiens Activity = 1.054 DrugMatrix in vivo data: Pathology
NPT2 Others Unspecified Activity = 0.927 DrugMatrix in vivo data: Pathology
NPT2382 Cell Line SW948 Homo sapiens Activity = 1 DrugMatrix in vivo data: Pathology
NPT3247 Individual Protein Serine/threonine-protein kinase PAK 3 Homo sapiens Kd = 16 nM DrugMatrix in vivo data: Biochemistry
NPT1977 Cell Line LOUCY Homo sapiens IC50 = 11987.49 nM DrugMatrix in vivo data: Hematology
NPT1993 Cell Line LP-1 Homo sapiens IC50 = 9780.83 nM 15646539
NPT2168 Cell Line MZ2-MEL Homo sapiens IC50 = 15225.11 nM PubChem BioAssay data set
NPT139 Cell Line HT-29 Homo sapiens Activity = 88.9 % PubChem BioAssay data set
NPT1926 Cell Line CP66-MEL Homo sapiens IC50 = 531468.01 nM 25569119
NPT1689 Individual Protein Tyrosine-protein kinase JAK1 Homo sapiens Kd = 49 nM 21051535
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens IC50 = 0.7 nM PubChem BioAssay data set
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 150 nM 26425784
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 140 nM 21044847
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 21044847
NPT3267 Individual Protein Macrophage colony stimulating factor receptor Homo sapiens Kd = 2.5 nM 21044847
NPT728 Individual Protein Serine/threonine-protein kinase AKT Homo sapiens Kd > 10000 nM 21044847
NPT3214 Individual Protein Tyrosine-protein kinase ABL2 Homo sapiens Kd = 1000 nM 21044847
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd = 6800 nM 21044847
NPT1985 Cell Line OPM-2 Homo sapiens IC50 = 3059.54 nM 19902967
NPT3214 Individual Protein Tyrosine-protein kinase ABL2 Homo sapiens Kd = 1000 nM 12542346
NPT3244 Individual Protein Tyrosine-protein kinase FER Homo sapiens Kd = 1100 nM 12565968
NPT2142 Cell Line REH Homo sapiens IC50 = 12649.81 nM 12729643
NPT2049 Cell Line HT Homo sapiens IC50 = 69470.83 nM PubChem BioAssay data set
NPT3109 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens Kd = 77 nM 20014752
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens IC50 = 35 nM DrugMatrix in vitro pharmacology data
NPT3383 Individual Protein Serine/threonine-protein kinase 32A Homo sapiens Kd > 10000 nM 22194678
NPT3220 Individual Protein Ephrin type-A receptor 6 Homo sapiens Kd = 960 nM 22194678
NPT3381 Individual Protein Misshapen-like kinase 1 Homo sapiens Kd = 29 nM PubChem BioAssay data set
NPT1659 Individual Protein Tyrosine-protein kinase receptor UFO Homo sapiens Kd = 9 nM PubChem BioAssay data set
NPT2456 Cell Line TE-11 Homo sapiens IC50 = 1839.85 nM PubChem BioAssay data set
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT2071 Cell Line MMAC-SF Homo sapiens IC50 = 6109.49 nM 22275465
NPT116 Cell Line HL-60 Homo sapiens IC50 = 3530 nM 26110337
NPT2191 Cell Line GCIY Homo sapiens IC50 = 392528.84 nM DailyMed
NPT2691 Individual Protein Voltage-gated L-type calcium channel alpha-1C subunit Homo sapiens IC50 = 199526.23 nM DailyMed
NPT2020 Cell Line JVM-3 Homo sapiens IC50 = 1600617.87 nM DailyMed
NPT2505 Cell Line NCI-H520 Activity = 0.89 1846923
NPT2 Others Unspecified Activity = 1.31 8410981
NPT2508 Cell Line SW1710 Homo sapiens Activity = 1.116 15332840
NPT3424 Individual Protein Microtubule-associated serine/threonine-protein kinase 1 Homo sapiens Kd = 200 nM PubChem BioAssay data set
NPT3233 Individual Protein Serine/threonine-protein kinase 38-like Homo sapiens Kd = 970 nM PubChem BioAssay data set
NPT3208 Individual Protein Serine/threonine-protein kinase 36 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT2137 Cell Line MS-1 Homo sapiens IC50 = 3837.78 nM PubChem BioAssay data set
NPT3223 Individual Protein Phosphorylase kinase gamma subunit 2 Homo sapiens Kd = 39 nM 16499325
NPT3299 Individual Protein Testis-specific serine/threonine-protein kinase 1 Homo sapiens Kd = 6300 nM 23268606
NPT1987 Cell Line RPMI-8866 Homo sapiens IC50 = 75234.81 nM 19836230
NPT1970 Cell Line THP-1 Homo sapiens IC50 = 500 nM 20363636
NPT1916 Cell Line ACN Homo sapiens IC50 = 58168.68 nM 22934671
NPT2 Others Unspecified EC50 > 1000 nM 9873670
NPT3109 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens Kd = 41 nM 17206139
NPT1436 Individual Protein Focal adhesion kinase 1 Homo sapiens IC50 = 1600 nM 10.6019/CHEMBL1201861
NPT1705 Individual Protein Ribosomal protein S6 kinase alpha 3 Homo sapiens IC50 = 183.9 nM 10.6019/CHEMBL1201861
NPT1661 Individual Protein ALK tyrosine kinase receptor Homo sapiens IC50 = 54.64 nM 10.6019/CHEMBL1201861
NPT3106 Individual Protein Ribosomal protein S6 kinase alpha 1 Homo sapiens IC50 = 131.3 nM 10.6019/CHEMBL1201861
NPT1432 Individual Protein Serine/threonine-protein kinase Aurora-A Homo sapiens IC50 = 1837 nM 10.6019/CHEMBL1201861
NPT1608 Individual Protein Serine/threonine-protein kinase Chk1 Homo sapiens IC50 = 77.27 nM 10.6019/CHEMBL1201861
NPT3114 Individual Protein Dual-specificity tyrosine-phosphorylation regulated kinase 1A Homo sapiens Kd = 200 nM 10.6019/CHEMBL1201861
NPT3337 Individual Protein Serine/threonine-protein kinase DCLK3 Homo sapiens Kd = 110 nM 10.6019/CHEMBL1201861
NPT6219 Individual Protein Protein delta homolog 1 Homo sapiens Kd = 100 nM 10.6019/CHEMBL1201861
NPT2377 Cell Line NCI-H2087 Homo sapiens Activity = 0.82 10.6019/CHEMBL1201861
NPT2 Others Unspecified Activity = 0.869 10.6019/CHEMBL1201861
NPT2355 Cell Line NCI-H2029 Homo sapiens Activity = 1.168 10.6019/CHEMBL1201861
NPT2 Others Unspecified Activity = 0.898 10.6019/CHEMBL1201861
NPT2 Others Unspecified Activity = 0.927 10.6019/CHEMBL1201861
NPT2368 Cell Line NCI-H2030 Homo sapiens Activity = 1.127 10.6019/CHEMBL1201861
NPT2 Others Unspecified Activity = 1.025 10.6019/CHEMBL1201861
NPT2354 Cell Line NCI-H2009 Homo sapiens Activity = 0.945 10.6019/CHEMBL1201861
NPT2341 Cell Line NCI-H1975 Homo sapiens Activity = 0.749 10.6019/CHEMBL1201861
NPT3318 Individual Protein MAP/microtubule affinity-regulating kinase 4 Homo sapiens Kd = 3600 nM 10.6019/CHEMBL1201861
NPT3320 Individual Protein Proto-oncogene tyrosine-protein kinase MER Homo sapiens Kd = 26 nM 10.6019/CHEMBL1201861
NPT2 Others Unspecified IC50 = 1000 nM 10.6019/CHEMBL1201861
NPT1663 Individual Protein Tyrosine-protein kinase YES Homo sapiens Kd = 120 nM 10.6019/CHEMBL1201861
NPT2133 Cell Line KM-H2 Homo sapiens IC50 = 44957.74 nM 10.6019/CHEMBL1201861
NPT81 Cell Line A549 Homo sapiens IC50 = 18580 nM 10.6019/CHEMBL1201861
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 10.6019/CHEMBL1201861
NPT2103 Cell Line MONO-MAC-6 Homo sapiens IC50 = 33.8 nM 10.6019/CHEMBL1201861
NPT1681 Individual Protein Dual specificty protein kinase CLK1 Homo sapiens Kd = 22 nM 25316316
NPT3271 Individual Protein NT-3 growth factor receptor Homo sapiens Kd = 5100 nM 25316316
NPT2195 Cell Line LC4-1 Homo sapiens IC50 = 4380.7 nM 12444694
NPT3305 Individual Protein Chaperone activity of bc1 complex-like, mitochondrial Homo sapiens Kd > 10000 nM 17418579
NPT2087 Cell Line L-540 Homo sapiens IC50 = 66545.24 nM 18053715
NPT2415 Cell Line SKG-IIIa Homo sapiens Activity = 1.083 15921413
NPT2 Others Unspecified Activity = 0.968 15921413
NPT2 Others Unspecified Activity = 1.17 15387649
NPT399 Cell Line SF-295 Homo sapiens Activity = 0.811 15387649
NPT2109 Cell Line SCH Homo sapiens Activity = 1.025 22545792
NPT2110 Cell Line SCLC-21H Homo sapiens Activity = 1.033 22545792
NPT134 Cell Line SK-BR-3 Homo sapiens Activity = 1.235 22545792
NPT4616 Cell Line SK-CO-1 Homo sapiens Activity = 0.811 22545792
NPT2155 Cell Line SHP77 Homo sapiens Activity = 0.726 22545792
NPT6436 Cell Line SISO Homo sapiens Activity = 1.025 22545792
NPT1444 Individual Protein PI3-kinase p110-alpha subunit Homo sapiens Kd > 10000 nM 24697496
NPT1444 Individual Protein PI3-kinase p110-alpha subunit Homo sapiens Kd > 10000 nM 26351041
NPT3376 Individual Protein PI3-kinase p110-beta subunit Homo sapiens Kd > 10000 nM 26351041
NPT1671 Individual Protein AMP-activated protein kinase, alpha-2 subunit Homo sapiens Kd = 89 nM 26351041
NPT881 Individual Protein Protein kinase C delta Homo sapiens Kd > 10000 nM 26351041
NPT483 Individual Protein Prelamin-A/C Homo sapiens Potency = 7079.5 nM 26351041
NPT2073 Cell Line NCI-H1304 Homo sapiens IC50 = 8206.61 nM 10785428
NPT2 Others Unspecified IC50 = 16400 nM 15620242
NPT1951 Cell Line CMK Homo sapiens IC50 = 1955.17 nM 22440015
NPT2143 Cell Line ST486 Homo sapiens IC50 = 6347.1 nM 10543899
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 1000 nM 17488128
NPT1917 Cell Line CA46 Homo sapiens IC50 = 7580.12 nM 16124771
NPT2 Others Unspecified IC50 = 7970 nM 18163584
NPT3234 Individual Protein Ribosomal protein S6 kinase alpha 2 Homo sapiens Kd = 8400 nM 19260658
NPT2 Others Unspecified Activity = 1.081 19115838
NPT3340 Individual Protein Serine/threonine-protein kinase Nek1 Homo sapiens Kd > 10000 nM 19115838
NPT2 Others Unspecified Activity = 0.924 19115838
NPT2302 Cell Line 639-V Homo sapiens Activity = 1.049 20627559
NPT2 Others Unspecified Activity = 1.024 21353549
NPT1676 Individual Protein CaM kinase II gamma Homo sapiens Kd = 760 nM 10217729
NPT3334 Individual Protein Citron Rho-interacting kinase Homo sapiens Kd = 3900 nM 15974602
NPT3403 Individual Protein Cyclin-dependent kinase-like 2 Homo sapiens Kd = 1100 nM 20503985
NPT1678 Individual Protein CaM-kinase kinase beta Homo sapiens Kd = 1500 nM 20503985
NPT3338 Individual Protein Myosin IIIA Homo sapiens Kd > 10000 nM 8254346
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 55 nM 18081255
NPT3369 Individual Protein Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens Kd = 670 nM 18081255
NPT1711 Individual Protein Serine/threonine-protein kinase MST1 Homo sapiens Kd = 19 nM 17488128
NPT3241 Individual Protein Serine/threonine-protein kinase NEK9 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT111 Cell Line K562 Homo sapiens IC50 = 11870.23 nM PubChem BioAssay data set
NPT2009 Cell Line NCI-H2081 Homo sapiens IC50 = 228219.53 nM 9784152
NPT65 Cell Line HepG2 Homo sapiens Activity > 75 % 8158155
NPT1446 Individual Protein PI3-kinase p110-delta subunit Homo sapiens IC50 = 12000 nM 16989516
NPT1445 Individual Protein PI3-kinase p110-gamma subunit Homo sapiens IC50 = 13000 nM 16989516
NPT1444 Individual Protein PI3-kinase p110-alpha subunit Homo sapiens IC50 = 11000 nM 16989516
NPT3376 Individual Protein PI3-kinase p110-beta subunit Homo sapiens IC50 > 50000 nM 22858297
NPT940 Individual Protein Serine/threonine-protein kinase mTOR Homo sapiens IC50 > 50000 nM 22799262
NPT2556 Individual Protein DNA-dependent protein kinase Homo sapiens IC50 > 50000 nM 22799262
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 2800 nM 26343828
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 = 172100 nM 11000043
NPT1990 Cell Line J-RT3-T3-5 Homo sapiens IC50 = 6079.09 nM 21696969
NPT2032 Cell Line HAL-01 Homo sapiens IC50 = 2059.46 nM 23186727
NPT2750 Individual Protein Tyrosine-protein kinase BMX Homo sapiens Kd > 10000 nM 23819871
NPT3235 Individual Protein MAP/microtubule affinity-regulating kinase 2 Homo sapiens Kd = 320 nM 23819871
NPT1307 Cell Line Calu-1 Homo sapiens Activity = 0.936 22413887
NPT2299 Cell Line CAL-51 Homo sapiens Activity = 1.061 22413887
NPT2300 Cell Line CAL-54 Homo sapiens Activity = 0.94 22413887
NPT2305 Cell Line CAL-85-1 Homo sapiens Activity = 0.902 22413887
NPT2301 Cell Line CAL-62 Homo sapiens Activity = 0.971 22413887
NPT2286 Cell Line CAL-120 Homo sapiens Activity = 1.134 17363259
NPT2289 Cell Line CAL-12T Homo sapiens Activity = 1.004 17363259
NPT1925 Cell Line CAL-148 Homo sapiens Activity = 0.842 17363259
NPT2 Others Unspecified Activity = 0.842 17363259
NPT2065 Cell Line EW-1 Homo sapiens IC50 = 4679.11 nM 22691179
NPT1086 Cell Line SK-HEP1 Homo sapiens Activity = 1.024 22691179
NPT2150 Cell Line NCI-H1648 Homo sapiens IC50 = 9138.34 nM 9341921
NPT1691 Individual Protein Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens Kd > 10000 nM 9548852
NPT2106 Cell Line NH-12 Homo sapiens IC50 = 43935.91 nM 17547460
NPT1616 Individual Protein MAP kinase p38 beta Homo sapiens Kd > 10000 nM 20702092
NPT3252 Individual Protein Serine/threonine-protein kinase PFTAIRE-1 Homo sapiens Kd = 270 nM PubChem BioAssay data set
NPT65 Cell Line HepG2 Homo sapiens IC50 = 5610 nM 3236014
NPT2 Others Unspecified IC50 = 4780 nM 2453615
NPT2 Others Unspecified Activity = 0.54 9463110
NPT2 Others Unspecified Activity = 0.54 18510362
NPT2 Others Unspecified Activity = 1.033 18510362
NPT2 Others Unspecified Activity = 0.792 18510362
NPT2 Others Unspecified Activity = 0.892 18510362
NPT2 Others Unspecified Activity = 1.092 1533423
NPT2 Others Unspecified Activity = 1.344 1533423
NPT2 Others Unspecified Activity = 0.959 PubChem BioAssay data set
NPT1505 Cell Line J82 Homo sapiens Activity = 1 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.802 PubChem BioAssay data set
NPT1980 Cell Line NB14 Homo sapiens IC50 = 10927.65 nM PubChem BioAssay data set
NPT3326 Individual Protein Mitogen-activated protein kinase kinase kinase 9 Homo sapiens Kd = 3400 nM 10924160
NPT1675 Individual Protein CaM kinase II delta Homo sapiens Kd = 420 nM PubChem BioAssay data set
NPT3353 Individual Protein TGF-beta receptor type I Homo sapiens Kd > 10000 nM 16933872
NPT2154 Cell Line SH-4 Homo sapiens IC50 = 5483.7 nM 16933872
NPT3350 Individual Protein Tyrosine-protein kinase Srms Homo sapiens Kd > 10000 nM 16933872
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Kd = 0.075 nM PubChem BioAssay data set
NPT3247 Individual Protein Serine/threonine-protein kinase PAK 3 Homo sapiens Kd = 16 nM PubChem BioAssay data set
NPT1694 Individual Protein Serine/threonine-protein kinase OSR1 Homo sapiens Kd = 530 nM PubChem BioAssay data set
NPT3020 Individual Protein Platelet-derived growth factor receptor alpha Homo sapiens Kd = 0.79 nM PubChem BioAssay data set
NPT1696 Individual Protein Serine/threonine-protein kinase PAK7 Homo sapiens Kd = 640 nM PubChem BioAssay data set
NPT1698 Individual Protein Serine/threonine-protein kinase PCTAIRE-1 Homo sapiens Kd = 150 nM PubChem BioAssay data set
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 18.9 nM 21084196
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 = 172100 nM 8759172
NPT1907 Cell Line EB2 Homo sapiens IC50 = 656710.31 nM 25052206
NPT2 Others Unspecified Activity = 93.35 % 25052206
NPT2078 Cell Line SK-UT-1 Homo sapiens IC50 = 49882.54 nM 19334707
NPT1657 Individual Protein Serine/threonine-protein kinase NEK6 Homo sapiens Kd > 10000 nM 10924160
NPT2067 Cell Line KARPAS-299 Homo sapiens IC50 = 2113.13 nM PubChem BioAssay data set
NPT1949 Cell Line BL-41 Homo sapiens IC50 = 2912.22 nM PubChem BioAssay data set
NPT2510 Cell Line GCT Homo sapiens Activity = 0.931 18723353
NPT2484 Cell Line GAMG Homo sapiens Activity = 0.998 18723353
NPT2 Others Unspecified Activity = 0.935 18723353
NPT2458 Cell Line FTC-133 Homo sapiens Activity = 1.022 18723353
NPT2470 Cell Line G-402 Homo sapiens Activity = 0.841 18524584
NPT2468 Cell Line G-361 Homo sapiens Activity = 1.183 20850311
NPT2 Others Unspecified Activity = 0.939 17098429
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens Kd = 12 nM 10924160
NPT3263 Individual Protein Protein tyrosine kinase 2 beta Homo sapiens Kd = 82 nM 10924160
NPT6542 Individual Protein U4/U6 small nuclear ribonucleoprotein Prp4 Homo sapiens Kd = 390 nM 10924160
NPT3369 Individual Protein Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens Kd = 670 nM 10924160
NPT3366 Individual Protein Protein kinase C nu Homo sapiens Kd = 280 nM 10924160
NPT3365 Individual Protein Serine/threonine-protein kinase D2 Homo sapiens Kd = 380 nM 10924160
NPT3364 Individual Protein Protein kinase C mu Homo sapiens Kd = 310 nM 10924160
NPT1943 Cell Line CGTH-W-1 Homo sapiens IC50 = 30.94 nM PubChem BioAssay data set
NPT3260 Individual Protein Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Homo sapiens Kd = 39 nM 6620299
NPT2057 Cell Line NCI-H1155 Homo sapiens IC50 = 130531.69 nM 8450319
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.37 nM 8450319
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Inhibition = 70.6 % 9917283
NPT3020 Individual Protein Platelet-derived growth factor receptor alpha Homo sapiens Inhibition = 71.4 % 9917283
NPT65 Cell Line HepG2 Homo sapiens Activity > 75 % PubChem BioAssay data set
NPT3355 Individual Protein TGF-beta receptor type II Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT3120 Individual Protein Serine/threonine-protein kinase PAK 1 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT3391 Individual Protein Serine/threonine-protein kinase Nek3 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT3280 Individual Protein Serine/threonine-protein kinase c-TAK1 Homo sapiens Kd = 410 nM 23675651
NPT3111 Individual Protein Tyrosine-protein kinase Lyn Homo sapiens Kd = 270 nM 23675651
NPT3389 Individual Protein Mitogen-activated protein kinase kinase kinase 3 Homo sapiens Kd = 220 nM 23675651
NPT3388 Individual Protein Tyrosine-protein kinase CTK Homo sapiens Kd = 7700 nM 23675651
NPT3327 Individual Protein Mitogen-activated protein kinase kinase kinase 10 Homo sapiens Kd > 10000 nM 7623030
NPT3328 Individual Protein Mitogen-activated protein kinase kinase kinase 11 Homo sapiens Kd = 1300 nM 8350085
NPT1658 Individual Protein Serine/threonine-protein kinase NEK2 Homo sapiens Kd = 1400 nM 8350085
NPT3390 Individual Protein Macrophage-stimulating protein receptor Homo sapiens Kd > 10000 nM 8350085
NPT3291 Individual Protein Serine/threonine-protein kinase SRPK1 Homo sapiens Kd = 250 nM 8759172
NPT3319 Individual Protein Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens Kd = 700 nM 19091557
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 25 nM 8792623
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens IC50 = 10000 nM 20608716
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 30 nM 10.1016/S0960-894X(01)80522-9
NPT2074 Cell Line NCI-H1355 Homo sapiens IC50 = 7458.04 nM 21044847
NPT3227 Individual Protein Fibroblast growth factor receptor 3 Homo sapiens Kd = 300 nM 18260638
NPT2174 Cell Line TE-8 Homo sapiens IC50 = 2370.38 nM 25176187
NPT1672 Individual Protein CaM kinase I delta Homo sapiens Kd = 510 nM 17958396
NPT444 Individual Protein Ubiquitin carboxyl-terminal hydrolase 1 Homo sapiens Potency 89125.1 nM 19916528
NPT2546 Individual Protein Serine/threonine-protein kinase AKT3 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT728 Individual Protein Serine/threonine-protein kinase AKT Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT3343 Individual Protein Uncharacterized aarF domain-containing protein kinase 4 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT3305 Individual Protein Chaperone activity of bc1 complex-like, mitochondrial Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT3293 Individual Protein Activin receptor type-1B Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT3287 Individual Protein Activin receptor type-1 Homo sapiens Kd > 10000 nM 11473417
NPT3227 Individual Protein Fibroblast growth factor receptor 3 Homo sapiens Kd = 1400 nM 17228858
NPT3231 Individual Protein Dual specificity protein kinase CLK4 Homo sapiens Kd = 80 nM 26091285
NPT1994 Cell Line MHH-CALL-2 Homo sapiens IC50 = 5767.19 nM 22734800
NPT2188 Cell Line SJSA-1 Homo sapiens IC50 = 7660.61 nM 22703109
NPT737 Cell Line HUVEC Homo sapiens IC50 = 2750 nM 26222693
NPT2691 Individual Protein Voltage-gated L-type calcium channel alpha-1C subunit Homo sapiens IC50 = 79432.82 nM 19144449
NPT1707 Individual Protein Serine/threonine-protein kinase 10 Homo sapiens Kd = 19 nM 19902967
NPT2208 Cell Line KP-N-YS Homo sapiens IC50 = 14289.44 nM 25739048
NPT83 Cell Line MCF7 Homo sapiens IC50 = 27.1 nM 25739048
NPT83 Cell Line MCF7 Homo sapiens IC50 = 29.3 nM 25739048
NPT2 Others Unspecified Kd > 10000 nM 15730242
NPT3354 Individual Protein Ephrin type-A receptor 1 Homo sapiens Kd > 10000 nM 15730242
NPT3218 Individual Protein Ephrin type-A receptor 4 Homo sapiens Kd > 10000 nM 16252922
NPT2 Others Unspecified Kd > 10000 nM 16252922
NPT2 Others Unspecified Kd > 10000 nM 23305465
NPT3219 Individual Protein Ephrin type-A receptor 5 Homo sapiens Kd > 10000 nM 22292922
NPT3216 Individual Protein Ephrin type-A receptor 8 Homo sapiens Kd > 10000 nM 22292922
NPT1902 Cell Line ES1 Homo sapiens IC50 = 10298.42 nM 20384296
NPT1937 Cell Line CAS-1 Homo sapiens IC50 = 322440.62 nM 23327794
NPT1892 Cell Line H4 Rattus norvegicus Activity = 40 nM 23837944
NPT4149 Protein Complex Gamma-secretase Homo sapiens Inhibition = 26 % 19795841
NPT3277 Individual Protein Tyrosine-protein kinase receptor TYRO3 Homo sapiens Activity = 9 % 7473578
NPT3298 Individual Protein Serine/threonine-protein kinase TNNI3K Homo sapiens Kd > 10000 nM 15270571
NPT388 Cell Line NCI-H322M Homo sapiens IC50 = 116336.87 nM 18553926
NPT1700 Individual Protein Serine/threonine-protein kinase PIM2 Homo sapiens Kd > 10000 nM 24547740
NPT3222 Individual Protein AMP-activated protein kinase, alpha-1 subunit Homo sapiens Kd = 52 nM 25924023
NPT2013 Cell Line SK-MM-2 Homo sapiens IC50 = 5478.2 nM 24099364
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens GI50 = 9 nM 25299458
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens IC50 = 21 nM 25299458
NPT1685 Individual Protein Casein kinase I gamma 2 Homo sapiens Kd = 110 nM 25286284
NPT1686 Individual Protein Casein kinase I isoform gamma-3 Homo sapiens Kd = 240 nM 25286284
NPT1598 Individual Protein Casein kinase II alpha Homo sapiens Kd = 81 nM 19836230
NPT5888 Cell Line HPAC Homo sapiens Activity = 1.047 18363379
NPT2384 Cell Line HPAF-II Homo sapiens Activity = 1.089 18363379
NPT372 Cell Line HOP-92 Homo sapiens Activity = 0.935 15771446
NPT2 Others Unspecified Kd = 0.99 nM 11908979
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 43 nM 8021914
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.37 nM 8021914
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens Activity = 5 % 8021914
NPT3323 Individual Protein Cell division cycle 2-like protein kinase 6 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT1983 Cell Line NCI-H64 Homo sapiens IC50 = 1239989.26 nM 20429578
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 12 nM 24900361
NPT3168 Individual Protein Casein kinase I alpha Homo sapiens IC50 < 1 nM 18171023
NPT3354 Individual Protein Ephrin type-A receptor 1 Homo sapiens Kd > 10000 nM 26213786
NPT2061 Cell Line NCI-H889 Homo sapiens IC50 = 351121.04 nM 20594858
NPT1947 Cell Line D283 Med IC50 = 16848.86 nM 21530248
NPT2037 Cell Line NCI-H2107 Homo sapiens IC50 = 11598.42 nM 16574412
NPT3231 Individual Protein Dual specificity protein kinase CLK4 Homo sapiens Kd = 29 nM 16574412
NPT3431 Individual Protein Serine/threonine-protein kinase TAO1 Homo sapiens Kd = 890 nM 16574412
NPT3234 Individual Protein Ribosomal protein S6 kinase alpha 2 Homo sapiens Kd = 17 nM 20598535
NPT1684 Individual Protein Casein kinase I gamma 1 Homo sapiens Kd = 930 nM 26004578
NPT3432 Individual Protein Homeodomain-interacting protein kinase 2 Homo sapiens Kd = 31 nM 23746784
NPT3372 Individual Protein Fibroblast growth factor receptor 4 Homo sapiens Kd = 2100 nM 23746784
NPT1481 Individual Protein Fibroblast growth factor receptor 2 Homo sapiens Kd = 570 nM 23746784
NPT1480 Individual Protein Fibroblast growth factor receptor 1 Homo sapiens Kd = 520 nM 23746784
NPT3322 Individual Protein PITSLRE serine/threonine-protein kinase CDC2L2 Homo sapiens Kd > 10000 nM 23746784
NPT3433 Individual Protein Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma Homo sapiens Kd > 10000 nM 23746784
NPT4143 Protein Complex Platelet-derived growth factor receptor Mus musculus IC50 = 8 nM 18702471
NPT4143 Protein Complex Platelet-derived growth factor receptor Mus musculus IC50 < 7 nM 18702471
NPT4143 Protein Complex Platelet-derived growth factor receptor Mus musculus IC50 = 83 nM 12828470
NPT4143 Protein Complex Platelet-derived growth factor receptor Mus musculus IC50 < 7 nM 12828470
NPT3249 Individual Protein Tyrosine- and threonine-specific cdc2-inhibitory kinase Homo sapiens Kd > 10000 nM 21314138
NPT3219 Individual Protein Ephrin type-A receptor 5 Homo sapiens Kd = 5900 nM 20624681
NPT2064 Cell Line UACC-812 Homo sapiens Activity = 1.301 22168134
NPT2 Others Unspecified Activity = 0.951 8496706
NPT2 Others Unspecified Activity = 0.988 8496706
NPT2 Others Unspecified Activity = 0.737 8496706
NPT2362 Cell Line TYK-nu Homo sapiens Activity = 0.813 8496706
NPT2 Others Unspecified Activity = 1.256 8496706
NPT2 Others Unspecified Activity = 1.205 8496706
NPT2417 Cell Line UMUC3 Homo sapiens Activity = 0.97 8496706
NPT2425 Cell Line UMC-11 Homo sapiens Activity = 0.902 8496706
NPT2499 Cell Line KP-4 Homo sapiens Activity = 1.408 19199792
NPT2 Others Unspecified Activity = 1.223 19199792
NPT2 Others Unspecified Activity = 1.204 19199792
NPT2 Others Unspecified Activity = 1.032 19199792
NPT2 Others Unspecified Activity = 1.011 19199792
NPT2367 Cell Line KYSE-140 Homo sapiens Activity = 0.896 19199792
NPT2340 Cell Line KU-19-19 Homo sapiens Activity = 1.017 19199792
NPT2 Others Unspecified Activity = 1.056 19199792
NPT3286 Individual Protein Insulin receptor-related protein Homo sapiens Kd = 430 nM 19199792
NPT2574 Individual Protein Insulin receptor Homo sapiens Kd = 500 nM 19199792
NPT3275 Individual Protein Inhibitor of nuclear factor kappa B kinase epsilon subunit Homo sapiens Kd = 620 nM 20738103
NPT2374 Cell Line KYSE-180 Homo sapiens Activity = 1.099 20738103
NPT1689 Individual Protein Tyrosine-protein kinase JAK1 Homo sapiens Kd = 49 nM 20738103
NPT1439 Individual Protein Tyrosine-protein kinase ITK/TSK Homo sapiens Kd = 13 nM 20738103
NPT3288 Individual Protein Interleukin-1 receptor-associated kinase 3 Homo sapiens Kd = 940 nM 10.1007/s00044-011-9767-1
NPT3386 Individual Protein Interleukin-1 receptor-associated kinase 1 Homo sapiens Kd = 14 nM 15217282
NPT1674 Individual Protein CaM kinase II alpha Homo sapiens Kd = 80 nM PubChem BioAssay data set
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Inhibition = 90.6 % PubChem BioAssay data set
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 6100 nM 22652254
NPT3317 Individual Protein Serine/threonine-protein kinase MARK1 Homo sapiens Kd = 1200 nM 17512094
NPT2139 Cell Line NCI-H1581 Homo sapiens IC50 = 18086.59 nM 1791472
NPT2043 Cell Line SK-NEP-1 Homo sapiens Activity = 0.855 7525959
NPT136 Cell Line SK-N-SH Homo sapiens Activity = 1.006 7525959
NPT1986 Cell Line RPMI 8402 Homo sapiens IC50 = 2336.18 nM 23290052
NPT1712 Individual Protein TRAF2- and NCK-interacting kinase Homo sapiens Kd = 25 nM 18811205
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Inhibition = 74.6 % 2199608
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 12200 nM 24928402
NPT2430 Cell Line M059J Homo sapiens Activity = 1.113 23092389
NPT3112 Individual Protein Tyrosine-protein kinase FGR Homo sapiens Kd = 290 nM 22439644
NPT3294 Individual Protein Activin receptor type-2A Homo sapiens Kd > 10000 nM 25734623
NPT3230 Individual Protein Serine/threonine-protein kinase 17B Homo sapiens Kd = 110 nM 15104505
NPT306 Cell Line PC-3 Homo sapiens GI < 10 % 21667925
NPT2 Others Unspecified Activity = 1.356 25442304
NPT2641 Cell Line COLO 320 Homo sapiens Activity = 1.157 PubChem BioAssay data set
NPT182 Individual Protein Protein kinase C alpha Homo sapiens Kd = 6000 nM 12502331
NPT1371 Individual Protein Cyclin-dependent kinase 2 Homo sapiens Kd > 10000 nM 12502331
NPT3346 Individual Protein Cyclin-dependent kinase 7 Homo sapiens Kd = 330 nM 2089117
NPT2750 Individual Protein Tyrosine-protein kinase BMX Homo sapiens Kd > 10000 nM 7623047
NPT1677 Individual Protein CaM kinase IV Homo sapiens Kd = 890 nM 7623047
NPT1598 Individual Protein Casein kinase II alpha Homo sapiens Kd = 900 nM 7623047
NPT3168 Individual Protein Casein kinase I alpha Homo sapiens Kd = 99 nM 7623047
NPT3387 Individual Protein Receptor tyrosine-protein kinase erbB-3 Homo sapiens Kd > 10000 nM 20553004
NPT1480 Individual Protein Fibroblast growth factor receptor 1 Homo sapiens Kd = 1800 nM 22313254
NPT3342 Individual Protein Epithelial discoidin domain-containing receptor 1 Homo sapiens Kd = 2000 nM 21070010
NPT3332 Individual Protein Serine/threonine-protein kinase 24 Homo sapiens Kd = 63 nM 21288727
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 830 nM 12502317
NPT3338 Individual Protein Myosin IIIA Homo sapiens Kd = 3100 nM 26295746
NPT1693 Individual Protein Serine/threonine-protein kinase MST4 Homo sapiens Kd = 340 nM 22676269
NPT3427 Individual Protein Serine/threonine-protein kinase TAO3 Homo sapiens Kd = 210 nM 22676269
NPT3285 Individual Protein Serine/threonine protein kinase NLK Homo sapiens Kd > 10000 nM 22676269
NPT3228 Individual Protein Adaptor-associated kinase Homo sapiens Kd = 130 nM 25479041
NPT3235 Individual Protein MAP/microtubule affinity-regulating kinase 2 Homo sapiens Kd = 310 nM 25479041
NPT100 Individual Protein Glutaminase kidney isoform, mitochondrial Homo sapiens Potency 25118.9 nM 25468043
NPT1991 Cell Line KU812 cell line IC50 = 6694.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Activity = 1.035 PubChem BioAssay data set
NPT2463 Cell Line MDA-MB-157 Homo sapiens Activity = 1.059 PubChem BioAssay data set
NPT387 Cell Line M14 Homo sapiens Activity = 0.811 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 1.11 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.977 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 1.107 PubChem BioAssay data set
NPT2439 Cell Line MC-IXC Homo sapiens Activity = 0.9 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.788 PubChem BioAssay data set
NPT83 Cell Line MCF7 Homo sapiens Activity = 1.068 PubChem BioAssay data set
NPT784 Cell Line MDA-MB-468 Homo sapiens IC50 = 6.1 nM PubChem BioAssay data set
NPT400 Cell Line MDA-MB-435 Homo sapiens IC50 = 9.7 nM PubChem BioAssay data set
NPT1971 Cell Line GI-1 Homo sapiens IC50 = 8204.11 nM PubChem BioAssay data set
NPT1687 Individual Protein Death-associated protein kinase 3 Homo sapiens Kd = 22 nM 18537291
NPT1678 Individual Protein CaM-kinase kinase beta Homo sapiens Kd = 5800 nM 17685651
NPT2015 Cell Line U-266 Homo sapiens IC50 = 34278.15 nM 17253840
NPT2091 Cell Line SNU-5 Homo sapiens IC50 = 1501043.78 nM 15921418
NPT3256 Individual Protein Serine/threonine-protein kinase WEE1 Homo sapiens Kd = 1100 nM 16480866
NPT1820 Cell Line NCI-H1650 Homo sapiens Activity = 0.896 20055425
NPT2465 Cell Line NCI-H1623 Homo sapiens Activity = 0.969 20055425
NPT2139 Cell Line NCI-H1581 Homo sapiens Activity = 0.956 20469887
NPT2449 Cell Line NCI-H1573 Homo sapiens Activity = 0.895 20469887
NPT2 Others Unspecified Activity = 0.909 20662534
NPT2440 Cell Line NCI-H1563 Homo sapiens Activity = 0.901 20662534
NPT2431 Cell Line NCI-H1437 Homo sapiens Activity = 1.141 17603540
NPT2 Others Unspecified Activity = 0.972 17603540
NPT2410 Cell Line NCI-H1299 Homo sapiens Activity = 1.066 18936191
NPT2389 Cell Line NCI-H1048 Homo sapiens Activity = 0.941 18936191
NPT1682 Individual Protein Dual specificity protein kinase CLK2 Homo sapiens Kd = 20 nM 21177985
NPT1681 Individual Protein Dual specificty protein kinase CLK1 Homo sapiens Kd = 22 nM 21177985
NPT1680 Individual Protein Serine/threonine-protein kinase Chk2 Homo sapiens Kd = 7.1 nM 21177985
NPT1608 Individual Protein Serine/threonine-protein kinase Chk1 Homo sapiens Kd = 300 nM 21177985
NPT3266 Individual Protein Casein kinase I delta Homo sapiens Kd = 15 nM 21177985
NPT3168 Individual Protein Casein kinase I alpha Homo sapiens Kd = 550 nM 21177985
NPT881 Individual Protein Protein kinase C delta Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT1910 Cell Line ECC4 Homo sapiens IC50 = 98471.68 nM 2607352
NPT3311 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens Kd = 180 nM 17850214
NPT491 Individual Protein Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Kd = 130 nM 17850214
NPT2165 Cell Line KNS-42 Homo sapiens IC50 = 327343.8 nM 22464132
NPT2 Others Unspecified IC50 = 1200 nM 10.6019/CHEMBL1201861
NPT3270 Individual Protein Neurotrophic tyrosine kinase receptor type 2 Homo sapiens Kd = 590 nM 10.6019/CHEMBL1201861
NPT3377 Cell Line PC-9 IC50 = 10970 nM 10.6019/CHEMBL1201861
NPT2 Others Unspecified IC50 = 3 nM 10.6019/CHEMBL1201861
NPT1696 Individual Protein Serine/threonine-protein kinase PAK7 Homo sapiens Kd = 640 nM 10.6019/CHEMBL1201861
NPT3305 Individual Protein Chaperone activity of bc1 complex-like, mitochondrial Homo sapiens Kd > 10000 nM 10.6019/CHEMBL1201861
NPT1673 Individual Protein CaM kinase I gamma Homo sapiens Kd = 440 nM 10.6019/CHEMBL1201861
NPT1672 Individual Protein CaM kinase I delta Homo sapiens Kd = 510 nM 10.6019/CHEMBL1201861
NPT3216 Individual Protein Ephrin type-A receptor 8 Homo sapiens Kd > 10000 nM 10.6019/CHEMBL1201861
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens Kd = 8.7 nM 10.6019/CHEMBL1201861
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens Kd = 19 nM 10.6019/CHEMBL1201861
NPT3430 Individual Protein Receptor-interacting serine/threonine-protein kinase 4 Homo sapiens Kd = 2100 nM 10.6019/CHEMBL1201861
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens Kd = 5.8 nM 10.6019/CHEMBL1201861
NPT1649 Cell Line MV4-11 Homo sapiens IC50 = 0.2722 nM 10.6019/CHEMBL1201861
NPT1427 Individual Protein c-Jun N-terminal kinase 2 Homo sapiens Kd > 10000 nM 10.6019/CHEMBL1201861
NPT1444 Individual Protein PI3-kinase p110-alpha subunit Homo sapiens Kd > 10000 nM 10.6019/CHEMBL1201861
NPT1920 Cell Line ALL-PO Homo sapiens IC50 = 79.89 nM 11473423
NPT3290 Individual Protein Serine/threonine-protein kinase SIK2 Homo sapiens Kd = 580 nM 15974602
NPT1706 Individual Protein Serine/threonine-protein kinase 2 Homo sapiens Kd = 56 nM 15974602
NPT3348 Individual Protein NUAK family SNF1-like kinase 2 Homo sapiens Kd = 150 nM 20553004
NPT3291 Individual Protein Serine/threonine-protein kinase SRPK1 Homo sapiens Kd = 250 nM 20553004
NPT3292 Individual Protein Serine/threonine-protein kinase SRPK2 Homo sapiens Kd = 190 nM 20553004
NPT3419 Individual Protein Serine/threonine-protein kinase SRPK3 Homo sapiens Kd = 59 nM 20553004
NPT1708 Individual Protein Serine/threonine-protein kinase 16 Homo sapiens Kd = 250 nM 20553004
NPT1978 Cell Line MFM-223 Homo sapiens IC50 = 1294064.09 nM 25495797
NPT1691 Individual Protein Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens Kd > 10000 nM 10395508
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens Kd > 10000 nM 19481938
NPT3283 Individual Protein MAP kinase-interacting serine/threonine-protein kinase MNK1 Homo sapiens Kd > 10000 nM 19481938
NPT3213 Individual Protein MAP kinase signal-integrating kinase 2 Homo sapiens Kd > 10000 nM 9249983
NPT3330 Individual Protein Serine/threonine-protein kinase MRCK beta Homo sapiens Kd > 10000 nM 17696332
NPT2 Others Unspecified Survival = 73.74 % 17696332
NPT4542 Individual Protein NAD-dependent deacetylase sirtuin 3 Homo sapiens Inhibition = 26.4 % 17696332
NPT1928 Cell Line ATN-1 Homo sapiens IC50 = 3671.14 nM 17696332
NPT3306 Individual Protein Serine/threonine-protein kinase MRCK gamma Homo sapiens Kd > 10000 nM 18672864
NPT3219 Individual Protein Ephrin type-A receptor 5 Homo sapiens Kd = 1200 nM 21737271
NPT1989 Cell Line GOTO Homo sapiens IC50 = 31608.53 nM 21719287
NPT3106 Individual Protein Ribosomal protein S6 kinase alpha 1 Homo sapiens Kd = 140 nM 26110443
NPT3106 Individual Protein Ribosomal protein S6 kinase alpha 1 Homo sapiens Kd = 5000 nM 26110443
NPT3281 Individual Protein Dual specificity mitogen-activated protein kinase kinase 3 Homo sapiens Kd = 1700 nM 26178912
NPT491 Individual Protein Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Kd = 130 nM 26110443
NPT3395 Individual Protein Rhodopsin kinase Homo sapiens Kd = 290 nM 26110443
NPT3373 Individual Protein Proto-oncogene tyrosine-protein kinase ROS Homo sapiens Kd > 10000 nM 26110443
NPT1424 Individual Protein Serine/threonine-protein kinase RAF Homo sapiens Kd > 10000 nM 26110443
NPT4606 Cell Line BOKU Homo sapiens IC50 = 171831.27 nM 17067151
NPT1968 Cell Line OMC-1 Homo sapiens IC50 = 73153.43 nM PubChem BioAssay data set
NPT376 Cell Line A498 Homo sapiens IC50 = 4300 nM 15921418
NPT1976 Cell Line LNCaP-Clone-FGC Homo sapiens IC50 = 882124.32 nM 16562846
NPT2089 Cell Line NCI-H1395 Homo sapiens IC50 = 486680.57 nM 19013063
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 120 nM 24576210
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 240 nM 12713409
NPT3330 Individual Protein Serine/threonine-protein kinase MRCK beta Homo sapiens Kd > 10000 nM 11170656
NPT2025 Cell Line NCI-H747 Homo sapiens IC50 = 28919.47 nM 22085418
NPT1358 Cell Line LAMA-84 Homo sapiens IC50 = 2695.45 nM 15974609
NPT2069 Cell Line Lu-65 Homo sapiens IC50 = 192987.03 nM 19743809
NPT1675 Individual Protein CaM kinase II delta Homo sapiens Kd = 1100 nM 24709561
NPT2 Others Unspecified IC50 = 14940 nM 24709561
NPT3295 Individual Protein Activin receptor type-2B Homo sapiens Kd > 10000 nM 24709561
NPT3287 Individual Protein Activin receptor type-1 Homo sapiens Kd > 10000 nM 24709561
NPT3382 Individual Protein Serine/threonine-protein kinase ULK3 Homo sapiens Kd = 42 nM 24709561
NPT3339 Individual Protein Myosin-IIIB Homo sapiens Kd = 4500 nM 24709561
NPT3310 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens Kd = 16 nM 24709561
NPT1435 Individual Protein Receptor protein-tyrosine kinase erbB-4 Homo sapiens Kd > 10000 nM 24709561
NPT3336 Individual Protein Serine/threonine-protein kinase DCLK2 Homo sapiens Kd = 2700 nM 24709561
NPT1480 Individual Protein Fibroblast growth factor receptor 1 Homo sapiens IC50 = 1064 nM 24597894
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Kd = 30 nM 17346076
NPT1374 Cell Line WI-38 Homo sapiens IC50 = 8560 nM 20521771
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Activity = 99 % 21216145
NPT2109 Cell Line SCH Homo sapiens IC50 = 32848.46 nM 12662094
NPT1923 Cell Line DMS-153 Homo sapiens IC50 = 255682.13 nM 23501116
NPT3369 Individual Protein Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens Kd = 670 nM 19604701
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 = 172.1 nM 22413887
NPT5297 Cell Line COLO Activity = 0.974 7931367
NPT5297 Cell Line COLO Activity = 0.844 7931367
NPT5297 Cell Line COLO Activity = 0.934 7931367
NPT5297 Cell Line COLO Activity = 0.929 15043407
NPT3406 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 2 Homo sapiens Kd > 10000 nM 9514009
NPT3209 Individual Protein Mitogen-activated protein kinase kinase kinase 4 Homo sapiens Kd > 10000 nM 9514009
NPT1612 Individual Protein MAP kinase-activated protein kinase 5 Homo sapiens Kd > 10000 nM 9514009
NPT1441 Individual Protein MAP kinase-activated protein kinase 2 Homo sapiens Kd > 10000 nM 9514009
NPT3278 Individual Protein LIM domain kinase 2 Homo sapiens Kd > 10000 nM 9514009
NPT3242 Individual Protein LIM domain kinase 1 Homo sapiens Kd > 10000 nM 9514009
NPT3411 Individual Protein Mitogen-activated protein kinase kinase kinase 1 Homo sapiens Kd > 10000 nM 9514009
NPT3410 Individual Protein Serine/threonine-protein kinase MAK Homo sapiens Kd > 10000 nM 9514009
NPT3319 Individual Protein Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens Kd > 10000 nM 9514009
NPT3281 Individual Protein Dual specificity mitogen-activated protein kinase kinase 3 Homo sapiens Kd > 10000 nM 9514009
NPT3254 Individual Protein Ribosomal protein S6 kinase alpha 6 Homo sapiens Kd > 10000 nM 22749279
NPT3220 Individual Protein Ephrin type-A receptor 6 Homo sapiens Kd = 2000 nM 16180824
NPT3277 Individual Protein Tyrosine-protein kinase receptor TYRO3 Homo sapiens Activity = 99 % 2095375
NPT404 Cell Line CCRF-CEM Homo sapiens IC50 = 14416.94 nM 17567069
NPT1704 Individual Protein Serine/threonine-protein kinase RIO2 Homo sapiens Kd = 49 nM 22850207
NPT3268 Individual Protein Serine/threonine-protein kinase tousled-like 1 Homo sapiens Kd = 740 nM 12762806
NPT2 Others Unspecified IC50 = 16860 nM 12762806
NPT2 Others Unspecified Ratio IC50 = 0.6 11858750
NPT2 Others Unspecified IC50 = 4100 nM 12502346
NPT2110 Cell Line SCLC-21H Homo sapiens IC50 = 1214121.44 nM 7528786
NPT2 Others Unspecified Activity = 1.624 8229009
NPT2 Others Unspecified Activity = 0.889 8229009
NPT2 Others Unspecified Activity = 0.881 8229009
NPT2 Others Unspecified Activity = 1.01 8229009
NPT2 Others Unspecified Activity = 1.109 8229009
NPT381 Cell Line OVCAR-8 Homo sapiens Activity = 0.893 8229009
NPT2 Others Unspecified Activity = 1.267 15497935
NPT2400 Cell Line PA-1 Homo sapiens Activity = 0.973 15497935
NPT2 Others Unspecified Activity = 0.745 15497935
NPT2 Others Unspecified Activity = 1.196 15497935
NPT1598 Individual Protein Casein kinase II alpha Homo sapiens Kd = 81 nM PubChem BioAssay data set
NPT2 Others Unspecified EC50 = 13000 nM PubChem BioAssay data set
NPT2059 Cell Line NCI-H2141 Homo sapiens IC50 = 38084.3 nM PubChem BioAssay data set
NPT3297 Individual Protein Non-receptor tyrosine-protein kinase TNK1 Homo sapiens Kd = 680 nM 4040154
NPT139 Cell Line HT-29 Homo sapiens TGI = 53.83 % 23031596
NPT1094 Cell Line 697 Homo sapiens IC50 = 614.25 nM 8350087
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 4 nM 22264170
NPT3349 Individual Protein Serine/threonine-protein kinase SIK1 Homo sapiens Kd = 3200 nM 10.1016/S0960-894X(01)80935-5
NPT579 Cell Line DLD-1 Homo sapiens Activity = 52.7 % 9767644
NPT1649 Cell Line MV4-11 Homo sapiens Activity = 1.4 % 9767644
NPT81 Cell Line A549 Homo sapiens Activity = 37.4 % 9767644
NPT579 Cell Line DLD-1 Homo sapiens Activity = 92.9 % 9767644
NPT81 Cell Line A549 Homo sapiens Activity = 102.5 % 9767644
NPT1965 Cell Line DEL Homo sapiens IC50 = 2084.82 nM 17060530
NPT2086 Cell Line L-428 Homo sapiens IC50 = 18015.08 nM 17060530
NPT3267 Individual Protein Macrophage colony stimulating factor receptor Homo sapiens Activity = 37 % 17116681
NPT3267 Individual Protein Macrophage colony stimulating factor receptor Homo sapiens Activity = 90 % 17116681
NPT2122 Cell Line MC116 Homo sapiens IC50 = 4430.81 nM 17043131
NPT2509 Cell Line SW1783 Homo sapiens Activity = 0.873 17129641
NPT1312 Cell Line SW1990 Homo sapiens Activity = 1.053 17129641
NPT2481 Cell Line SW1088 Homo sapiens Activity = 0.744 17189664
NPT2 Others Unspecified Activity = 1.315 17189664
NPT2 Others Unspecified Activity = 1.096 17189664
NPT2483 Cell Line SW13 Homo sapiens Activity = 1.009 17189664
NPT2495 Cell Line SW1417 Homo sapiens Activity = 1.119 17189664
NPT2496 Cell Line SW1463 Homo sapiens Activity = 1.27 17189664
NPT2 Others Unspecified Activity = 0.79 17189664
NPT1577 Cell Line SW1573 Homo sapiens Activity = 0.787 17189664
NPT2 Others Unspecified Activity = 0.943 17618124
NPT3377 Cell Line PC-9 Activity = 0.846 17618124
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.37 nM 17618124
NPT461 Cell Line PANC-1 Homo sapiens Activity = 1.158 17084947
NPT2181 Cell Line MEG-01 Homo sapiens IC50 = 1835.63 nM 17027268
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 140 nM 18267360
NPT3262 Individual Protein Serine/threonine-protein kinase PRKX Homo sapiens Kd > 10000 nM 17420206
NPT91 Cell Line KB Homo sapiens GI < 10 % 17420206
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Inhibition = 84.8 % 17420206
NPT1125 Cell Line T98G Homo sapiens Activity = 0.84 17420206
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd = 6800 nM 17420206
NPT1967 Cell Line NCI-H526 Homo sapiens IC50 = 55135.4 nM 18299196
NPT1440 Individual Protein Tyrosine-protein kinase JAK3 Homo sapiens Kd = 1200 nM 17646161
NPT3211 Individual Protein Ephrin type-A receptor 7 Homo sapiens Kd = 2400 nM 17438050
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 74 nM 17470649
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 140 nM 17470649
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 730 nM 17470649
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 370 nM 17470649
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 3600 nM 17470649
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 890 nM 17470649
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 76 nM 17470649
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 150 nM 17470649
NPT2001 Cell Line JAR Homo sapiens IC50 = 3988.32 nM 9358638
NPT3267 Individual Protein Macrophage colony stimulating factor receptor Homo sapiens IC50 = 155 nM 18824352
NPT2129 Cell Line SNU-C1 Homo sapiens IC50 = 67427.57 nM 18990580
NPT1682 Individual Protein Dual specificity protein kinase CLK2 Homo sapiens Kd = 20 nM 18990580
NPT1705 Individual Protein Ribosomal protein S6 kinase alpha 3 Homo sapiens Kd = 55 nM 17548499
NPT2155 Cell Line SHP77 Homo sapiens IC50 = 51267.81 nM 17502412
NPT728 Individual Protein Serine/threonine-protein kinase AKT Homo sapiens Kd > 10000 nM 19926364
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 22.6 nM 19647352
NPT2341 Cell Line NCI-H1975 Homo sapiens EC50 > 1000 nM 20116901
NPT301 Individual Protein Vascular endothelial growth factor receptor 1 Homo sapiens Inhibition = 87.1 % 20116901
NPT2 Others Unspecified Kd > 10000 nM 19884366
NPT3230 Individual Protein Serine/threonine-protein kinase 17B Homo sapiens Kd = 220 nM 19949057
NPT1702 Individual Protein Serine/threonine-protein kinase PLK4 Homo sapiens Kd = 380 nM 19949057
NPT1711 Individual Protein Serine/threonine-protein kinase MST1 Homo sapiens Kd = 100 nM 20008772
NPT1712 Individual Protein TRAF2- and NCK-interacting kinase Homo sapiens Kd = 25 nM 20008772
NPT3238 Individual Protein Dual specificity protein kinase TTK Homo sapiens Kd = 230 nM 20008772
NPT3260 Individual Protein Phosphatidylinositol-5-phosphate 4-kinase type-2 beta Homo sapiens Kd = 39 nM 20038628
NPT3329 Individual Protein Serine/threonine-protein kinase MRCK-A Homo sapiens Kd > 10000 nM 20573514
NPT1649 Cell Line MV4-11 Homo sapiens IC50 = 24.3 nM 18299404
NPT3226 Individual Protein Casein kinase I epsilon Homo sapiens Kd = 13 nM 18316525
NPT2141 Cell Line NOS-1 Homo sapiens IC50 = 15.3 nM 20123999
NPT761 Individual Protein Protein kinase C epsilon Homo sapiens Kd > 10000 nM 18809936
NPT2085 Cell Line Kasumi 1 IC50 = 166607.38 nM 18955526
NPT3374 Individual Protein Ribosomal protein S6 kinase alpha 4 Homo sapiens Kd = 96 nM 18955526
NPT1914 Cell Line COLO-824 Homo sapiens IC50 = 273365.03 nM 18955526
NPT3450 Individual Protein Putative uncharacterized serine/threonine-protein kinase SgK110 Homo sapiens Kd = 1900 nM 18725443
NPT3349 Individual Protein Serine/threonine-protein kinase SIK1 Homo sapiens Kd = 3200 nM 18725443
NPT3374 Individual Protein Ribosomal protein S6 kinase alpha 4 Homo sapiens Kd = 5000 nM 18725443
NPT1613 Individual Protein Ribosomal protein S6 kinase alpha 5 Homo sapiens Kd = 8400 nM 18725443
NPT3430 Individual Protein Receptor-interacting serine/threonine-protein kinase 4 Homo sapiens Kd = 2100 nM 18725443
NPT3254 Individual Protein Ribosomal protein S6 kinase alpha 6 Homo sapiens Kd = 2400 nM 18725443
NPT1705 Individual Protein Ribosomal protein S6 kinase alpha 3 Homo sapiens Kd = 2000 nM 18725443
NPT3234 Individual Protein Ribosomal protein S6 kinase alpha 2 Homo sapiens Kd = 1700 nM 18725443
NPT1630 Individual Protein CaM kinase II beta Homo sapiens Kd = 1400 nM 18955526
NPT2148 Cell Line LB771-HNC Homo sapiens IC50 = 333074.77 nM 18443129
NPT403 Cell Line UACC-257 Homo sapiens IC50 = 108945.85 nM 18458127
NPT3342 Individual Protein Epithelial discoidin domain-containing receptor 1 Homo sapiens Kd = 2000 nM 18299417
NPT2574 Individual Protein Insulin receptor Homo sapiens Kd = 180 nM PubChem BioAssay data set
NPT1711 Individual Protein Serine/threonine-protein kinase MST1 Homo sapiens Kd = 100 nM 19015356
NPT3237 Individual Protein Serine/threonine-protein kinase MST2 Mus musculus Kd = 160 nM 19015356
NPT1680 Individual Protein Serine/threonine-protein kinase Chk2 Homo sapiens IC50 = 16.84 nM 19029325
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens IC50 = 34 nM 19064900
NPT81 Cell Line A549 Homo sapiens IC50 = 2440 nM 19114678
NPT1083 Cell Line A-375 Homo sapiens IC50 = 11580 nM 19114678
NPT2177 Cell Line HDLM-2 Homo sapiens IC50 = 6321.09 nM 19124662
NPT3344 Individual Protein BR serine/threonine-protein kinase 2 Homo sapiens Kd = 1100 nM 19029333
NPT82 Cell Line MDA-MB-231 Homo sapiens EC50 > 1000 nM 19029333
NPT406 Cell Line RXF 393 Homo sapiens IC50 = 11483.43 nM 19029333
NPT1441 Individual Protein MAP kinase-activated protein kinase 2 Homo sapiens Kd > 10000 nM 19223646
NPT3414 Individual Protein Serine/threonine-protein kinase PLK2 Homo sapiens Kd = 4700 nM 19223646
NPT3230 Individual Protein Serine/threonine-protein kinase 17B Homo sapiens Kd = 110 nM 19223615
NPT3399 Individual Protein Dual-specificity tyrosine-phosphorylation regulated kinase 2 Homo sapiens Kd = 680 nM 19223615
NPT1709 Individual Protein Serine/threonine-protein kinase 17A Homo sapiens Kd = 1 nM 19223615
NPT1083 Cell Line A-375 Homo sapiens IC50 = 5400 nM 19223615
NPT147 Cell Line SK-MEL-2 Homo sapiens IC50 = 42640.52 nM 19223615
NPT2 Others Unspecified Activity = 0.936 19223615
NPT36 Individual Protein Tyrosine-protein kinase SRC Homo sapiens IC50 = 152.8 nM 19223615
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens IC50 > 20000 nM 19223615
NPT13 Individual Protein Tyrosine-protein kinase LCK Homo sapiens IC50 = 8.9 nM 19223615
NPT3300 Individual Protein Serine/threonine-protein kinase 32B Homo sapiens Kd > 10000 nM 19289528
NPT3404 Individual Protein Ephrin type-B receptor 6 Homo sapiens Kd = 850 nM 19651906
NPT139 Cell Line HT-29 Homo sapiens Activity = 1.16 19651906
NPT2428 Cell Line HT-3 Homo sapiens Activity = 0.975 19651906
NPT2438 Cell Line HTC-C3 Homo sapiens Activity = 0.689 19651906
NPT2 Others Unspecified Activity = 0.927 19651906
NPT2 Others Unspecified Activity = 0.845 19651906
NPT2471 Cell Line HuP-T3 Homo sapiens Activity = 1.215 19651906
NPT2472 Cell Line HuP-T4 Homo sapiens Activity = 0.98 19651906
NPT2486 Cell Line IGR-1 Homo sapiens Activity = 1.214 19651906
NPT2 Others Unspecified Activity = 0.89 19651906
NPT3212 Individual Protein Ephrin type-B receptor 1 Homo sapiens Kd = 480 nM 19651906
NPT2 Others Unspecified IC50 = 30 nM 19738026
NPT3252 Individual Protein Serine/threonine-protein kinase PFTAIRE-1 Homo sapiens Kd = 270 nM 19581457
NPT3415 Individual Protein Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma Homo sapiens Kd > 10000 nM 19581457
NPT3340 Individual Protein Serine/threonine-protein kinase Nek1 Homo sapiens Kd > 10000 nM 19581457
NPT3268 Individual Protein Serine/threonine-protein kinase tousled-like 1 Homo sapiens Kd = 740 nM 19581457
NPT3418 Individual Protein Serine/threonine-protein kinase Sgk3 Homo sapiens Kd = 220 nM 19581457
NPT3275 Individual Protein Inhibitor of nuclear factor kappa B kinase epsilon subunit Homo sapiens Kd = 620 nM 19581457
NPT3416 Individual Protein STE20/SPS1-related proline-alanine-rich protein kinase Homo sapiens Kd = 140 nM 19581457
NPT3417 Individual Protein Serine/threonine-protein kinase TBK1 Homo sapiens Kd = 120 nM 19581457
NPT3286 Individual Protein Insulin receptor-related protein Homo sapiens Kd = 430 nM 19581457
NPT1702 Individual Protein Serine/threonine-protein kinase PLK4 Homo sapiens Kd = 190 nM 19581457
NPT1432 Individual Protein Serine/threonine-protein kinase Aurora-A Homo sapiens Kd = 1700 nM 19581457
NPT3372 Individual Protein Fibroblast growth factor receptor 4 Homo sapiens Kd > 10000 nM 20585113
NPT2199 Cell Line OCUB-M Homo sapiens IC50 = 8565.08 nM 19581457
NPT3250 Individual Protein Serine/threonine-protein kinase PCTAIRE-2 Homo sapiens Kd = 1200 nM 19581457
NPT1615 Individual Protein MAP kinase p38 gamma Homo sapiens Kd > 10000 nM 19581457
NPT3206 Individual Protein Serine/threonine-protein kinase Aurora-C Homo sapiens Kd = 220 nM 19581457
NPT3292 Individual Protein Serine/threonine-protein kinase SRPK2 Homo sapiens Kd = 190 nM 19581457
NPT3320 Individual Protein Proto-oncogene tyrosine-protein kinase MER Homo sapiens Kd = 26 nM 19581457
NPT2574 Individual Protein Insulin receptor Homo sapiens Kd = 500 nM 19581457
NPT1433 Individual Protein Serine/threonine-protein kinase Aurora-B Homo sapiens Kd = 380 nM 19581457
NPT3269 Individual Protein Serine/threonine-protein kinase tousled-like 2 Homo sapiens Kd = 330 nM 19581457
NPT1675 Individual Protein CaM kinase II delta Homo sapiens Kd = 420 nM 19581457
NPT1708 Individual Protein Serine/threonine-protein kinase 16 Homo sapiens Kd = 250 nM 19581457
NPT3378 Individual Protein Serine/threonine-protein kinase SIK3 Homo sapiens Kd > 10000 nM 19581457
NPT3365 Individual Protein Serine/threonine-protein kinase D2 Homo sapiens Kd = 380 nM 21078949
NPT2404 Cell Line SW982 Homo sapiens IC50 = 4553.07 nM 20713660
NPT788 Cell Line SNU1 Homo sapiens Activity = 0.975 PubChem BioAssay data set
NPT4612 Cell Line SNG-M Homo sapiens Activity = 1.367 21339031
NPT1506 Cell Line SK-MES-1 Homo sapiens Activity = 0.833 21339031
NPT1506 Cell Line SK-MES-1 Homo sapiens Activity = 0.993 21377877
NPT146 Cell Line SK-OV-3 Homo sapiens Activity = 0.859 21377877
NPT2380 Cell Line SK-N-AS Homo sapiens Activity = 1.056 21377877
NPT311 Cell Line SK-LU-1 Homo sapiens Activity = 0.632 21377877
NPT2359 Cell Line SK-MEL-30 Homo sapiens Activity = 0.925 21377877
NPT2358 Cell Line SK-MEL3 Homo sapiens Activity = 1.178 21377877
NPT1444 Individual Protein PI3-kinase p110-alpha subunit Homo sapiens Kd > 10000 nM 21741732
NPT3224 Individual Protein Phosphorylase kinase gamma subunit 1 Homo sapiens Kd = 5.5 nM 21741732
NPT3020 Individual Protein Platelet-derived growth factor receptor alpha Homo sapiens Kd = 0.79 nM 21741732
NPT1698 Individual Protein Serine/threonine-protein kinase PCTAIRE-1 Homo sapiens Kd = 150 nM 21757359
NPT3270 Individual Protein Neurotrophic tyrosine kinase receptor type 2 Homo sapiens Kd = 590 nM 21757359
NPT3330 Individual Protein Serine/threonine-protein kinase MRCK beta Homo sapiens Kd > 10000 nM 21973054
NPT1707 Individual Protein Serine/threonine-protein kinase 10 Homo sapiens Kd = 19 nM 21981980
NPT3215 Individual Protein Tyrosine-protein kinase BRK Homo sapiens Kd = 4600 nM 21981980
NPT1444 Individual Protein PI3-kinase p110-alpha subunit Homo sapiens Kd > 10000 nM 21890359
NPT2 Others Unspecified Survival = 54.2 % DrugMatrix in vitro pharmacology data
NPT2000 Cell Line GR-ST Homo sapiens IC50 = 10220.69 nM DrugMatrix in vitro pharmacology data
NPT1689 Individual Protein Tyrosine-protein kinase JAK1 Homo sapiens Kd = 49 nM DrugMatrix in vitro pharmacology data
NPT3224 Individual Protein Phosphorylase kinase gamma subunit 1 Homo sapiens Kd = 5.5 nM DrugMatrix in vitro pharmacology data
NPT1925 Cell Line CAL-148 Homo sapiens IC50 = 1861288 nM DrugMatrix in vitro pharmacology data
NPT1689 Individual Protein Tyrosine-protein kinase JAK1 Homo sapiens Kd = 6000 nM DrugMatrix in vitro pharmacology data
NPT2028 Cell Line SK-N-FI Homo sapiens IC50 = 17691.26 nM 22001028
NPT3290 Individual Protein Serine/threonine-protein kinase SIK2 Homo sapiens Kd = 580 nM 22264752
NPT2060 Cell Line NCI-H2171 Homo sapiens IC50 = 123449.6 nM PubChem BioAssay data set
NPT2080 Cell Line EW-13 Homo sapiens IC50 = 55580.14 nM 22750009
NPT2185 Cell Line OCI-AML2 Homo sapiens IC50 = 1368.51 nM 15567297
NPT3251 Individual Protein Serine/threonine-protein kinase PCTAIRE-3 Homo sapiens Kd = 1700 nM 22939606
NPT1697 Individual Protein Serine/threonine-protein kinase PAK6 Homo sapiens Kd = 2400 nM 22939606
NPT3250 Individual Protein Serine/threonine-protein kinase PCTAIRE-2 Homo sapiens Kd = 1200 nM 22939606
NPT3284 Individual Protein Serine/threonine-protein kinase NEK7 Homo sapiens Kd = 4100 nM PubChem BioAssay data set
NPT1699 Individual Protein 3-phosphoinositide dependent protein kinase-1 Homo sapiens Kd = 3500 nM 23159805
NPT1952 Cell Line COLO-320-HSR Homo sapiens IC50 = 12156.49 nM 10.1007/s00044-011-9693-2
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 83100 nM 10.1007/s00044-012-9980-6
NPT116 Cell Line HL-60 Homo sapiens IC50 = 15500 nM 10.1007/s00044-011-9830-y
NPT1452 Cell Line C8166 Homo sapiens IC50 = 968734.91 nM 10.1007/s00044-010-9328-z
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 110 nM 10.1007/s00044-012-0209-5
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 380 nM 10.1007/s00044-012-0209-5
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 1.3 nM 10.1007/s00044-012-0209-5
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.41 nM 10.1007/s00044-012-0209-5
NPT2 Others Unspecified IC50 = 55600 nM 10.1007/s00044-013-0524-5
NPT400 Cell Line MDA-MB-435 Homo sapiens IC50 = 9300 nM 10.1007/s00044-012-0031-0
NPT3351 Individual Protein Tyrosine-protein kinase TEC Homo sapiens Kd > 10000 nM 10.1007/s00044-012-0129-4
NPT3352 Individual Protein Dual specificity testis-specific protein kinase 1 Homo sapiens Kd > 10000 nM 10.1007/s00044-012-0129-4
NPT1449 Individual Protein Tyrosine-protein kinase SYK Homo sapiens Kd > 10000 nM 10.1007/s00044-012-0129-4
NPT3431 Individual Protein Serine/threonine-protein kinase TAO1 Homo sapiens Kd > 10000 nM 10.1007/s00044-013-0550-3
NPT3350 Individual Protein Tyrosine-protein kinase Srms Homo sapiens Kd > 10000 nM 10.1007/s00044-013-0550-3
NPT3208 Individual Protein Serine/threonine-protein kinase 36 Homo sapiens Kd > 10000 nM 10.1584/jpestics.28.183
NPT3373 Individual Protein Proto-oncogene tyrosine-protein kinase ROS Homo sapiens Kd > 10000 nM 10.1584/jpestics.28.183
NPT3254 Individual Protein Ribosomal protein S6 kinase alpha 6 Homo sapiens Kd > 10000 nM 10.1584/jpestics.28.183
NPT1424 Individual Protein Serine/threonine-protein kinase RAF Homo sapiens Kd > 10000 nM 10.1584/jpestics.28.183
NPT1447 Individual Protein Serine/threonine-protein kinase RIPK2 Homo sapiens Kd > 10000 nM 10.1584/jpestics.28.183
NPT3205 Individual Protein Tyrosine-protein kinase HCK Homo sapiens IC50 = 190 nM 10.1007/s00044-013-0472-0
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens IC50 = 410 nM 10.1007/s00044-013-0472-0
NPT2 Others Unspecified IC50 = 110 nM 10.1007/s00044-013-0472-0
NPT36 Individual Protein Tyrosine-protein kinase SRC Homo sapiens IC50 = 400 nM 10.1007/s00044-013-0472-0
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 = 18000 nM 10.1007/s00044-013-0472-0
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 95 nM 10.1007/s00044-013-0472-0
NPT2572 Individual Protein Ephrin type-B receptor 4 Homo sapiens IC50 > 50000 nM 10.1007/s00044-013-0541-4
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Activity = 100 % 23252553
NPT3238 Individual Protein Dual specificity protein kinase TTK Homo sapiens Kd = 63 nM 24077525
NPT3210 Individual Protein BMP-2-inducible protein kinase Homo sapiens Kd = 5.5 nM DrugMatrix in vivo data: Pathology
NPT2005 Cell Line MHH-NB-11 Homo sapiens IC50 = 20552.08 nM DrugMatrix in vivo data: Pathology
NPT2 Others Unspecified Kd > 10000 nM DrugMatrix in vivo data: Pathology
NPT3405 Individual Protein Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Pathology
NPT1444 Individual Protein PI3-kinase p110-alpha subunit Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Pathology
NPT3437 Individual Protein Serine/threonine-protein kinase PFTAIRE-2 Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Pathology
NPT3392 Individual Protein Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Pathology
NPT2572 Individual Protein Ephrin type-B receptor 4 Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Pathology
NPT1444 Individual Protein PI3-kinase p110-alpha subunit Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Hematology
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 2300 nM 15646539
NPT308 Cell Line CAKI-1 Homo sapiens Activity = 0.876 24681985
NPT492 Cell Line Caco-2 Homo sapiens Activity = 1.029 24681985
NPT2 Others Unspecified Activity = 0.815 24681985
NPT2 Others Unspecified Activity = 1.017 24681985
NPT2 Others Unspecified Activity = 0.943 24681985
NPT2277 Cell Line C-33-A Homo sapiens Activity = 1.079 24499135
NPT2282 Cell Line C32 Homo sapiens Activity = 0.973 24499135
NPT2 Others Unspecified Activity = 1.135 619151
NPT1081 Cell Line BXPC-3 Homo sapiens Activity = 0.836 619151
NPT2 Others Unspecified Activity = 1.322 619151
NPT2 Others Unspecified IC50 = 36.8 nM 24751553
NPT788 Cell Line SNU1 Homo sapiens IC50 = 13344.96 nM 23344796
NPT926 Cell Line SK-MEL-1 Homo sapiens IC50 = 138129.55 nM 25495422
NPT3234 Individual Protein Ribosomal protein S6 kinase alpha 2 Homo sapiens Kd = 58 nM 26546212
NPT2310 Cell Line CaR-1 Homo sapiens Activity = 0.974 26510047
NPT1660 Individual Protein NUAK family SNF1-like kinase 1 Homo sapiens Kd = 48 nM 26881456
NPT2018 Cell Line GT3TKB Homo sapiens IC50 = 6607.63 nM 10.1039/C5MD00325C
NPT1649 Cell Line MV4-11 Homo sapiens IC50 = 9 nM 26920799
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens IC50 = 16 nM 26920799
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens IC50 = 15 nM 26920799
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 53 nM 26765953
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 17 nM 26765953
NPT1677 Individual Protein CaM kinase IV Homo sapiens Kd = 890 nM PubChem BioAssay data set
NPT3308 Individual Protein Serine/threonine-protein kinase LATS2 Homo sapiens Kd = 460 nM PubChem BioAssay data set
NPT1939 Cell Line 8-MG-BA Homo sapiens IC50 = 6515.07 nM 19943620
NPT1682 Individual Protein Dual specificity protein kinase CLK2 Homo sapiens Kd = 190 nM 19928832
NPT2 Others Unspecified GI50 = 870 nM 22409377
NPT2 Others Unspecified GI50 = 2480 nM 22409377
NPT1161 Cell Line CHO Cricetulus griseus GI50 = 2030 nM 22409377
NPT3437 Individual Protein Serine/threonine-protein kinase PFTAIRE-2 Homo sapiens Kd > 10000 nM 12608854
NPT3438 Individual Protein G protein-coupled receptor kinase 7 Homo sapiens Kd = 180 nM 12608854
NPT3266 Individual Protein Casein kinase I delta Homo sapiens Kd = 15 nM 12608854
NPT1427 Individual Protein c-Jun N-terminal kinase 2 Homo sapiens Kd = 2400 nM 16724831
NPT3363 Individual Protein Mitogen-activated protein kinase 15 Homo sapiens Kd > 10000 nM 15730254
NPT3258 Individual Protein Mixed lineage kinase 7 Homo sapiens Kd > 10000 nM 15730254
NPT282 Individual Protein MAP kinase ERK2 Homo sapiens Kd > 10000 nM 16643051
NPT3114 Individual Protein Dual-specificity tyrosine-phosphorylation regulated kinase 1A Homo sapiens Kd = 200 nM 16643051
NPT3284 Individual Protein Serine/threonine-protein kinase NEK7 Homo sapiens Kd = 4100 nM 16643051
NPT2105 Cell Line NCI-H1436 Homo sapiens IC50 = 613542.78 nM PubChem BioAssay data set
NPT1081 Cell Line BXPC-3 Homo sapiens IC50 = 3630 nM PubChem BioAssay data set
NPT550 Cell Line T-24 Homo sapiens IC50 = 2440 nM PubChem BioAssay data set
NPT458 Cell Line IGROV-1 Homo sapiens Activity = 1.02 22873794
NPT2 Others Unspecified Activity = 0.961 21146414
NPT2 Others Unspecified Activity = 1.351 21146414
NPT2 Others Unspecified Activity = 1.031 21146414
NPT4490 Cell Line IMR-90 Homo sapiens Activity = 1.035 21146414
NPT2 Others Unspecified Activity = 1.047 21146414
NPT2 Others Unspecified Activity = 0.718 22873794
NPT4617 Cell Line IPC-298 Homo sapiens Activity = 1.143 22932311
NPT2738 Cell Line Ishikawa Homo sapiens Activity = 0.948 22932311
NPT2738 Cell Line Ishikawa Homo sapiens Activity = 1.003 22932311
NPT2205 Cell Line IST-MEL1 Homo sapiens IC50 = 12869.45 nM 18303847
NPT3325 Individual Protein Myosin light chain kinase, smooth muscle Gallus gallus Kd = 23 nM 21684166
NPT2102 Cell Line MC-CAR Homo sapiens IC50 = 8335.8 nM 9014350
NPT1957 Cell Line D-502MG Homo sapiens IC50 = 984380.98 nM 11087594
NPT2176 Cell Line HD-MY-Z Homo sapiens IC50 = 5173.01 nM 14640517
NPT3445 Individual Protein Serine/threonine-protein kinase NIM1 Homo sapiens Kd = 850 nM 19388705
NPT2626 Individual Protein Myosin light chain kinase, smooth muscle Homo sapiens Kd = 280 nM 19388705
NPT3333 Individual Protein Muscle, skeletal receptor tyrosine protein kinase Homo sapiens Kd = 490 nM 19388705
NPT1710 Individual Protein Serine/threonine-protein kinase 38 Homo sapiens Kd = 410 nM 20704304
NPT3243 Individual Protein myosin light chain kinase 2 Homo sapiens Kd = 49 nM 20704304
NPT3332 Individual Protein Serine/threonine-protein kinase 24 Homo sapiens Kd = 63 nM 22182501
NPT1693 Individual Protein Serine/threonine-protein kinase MST4 Homo sapiens Kd = 340 nM 22182501
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 83.1 nM 22182501
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens IC50 = 10 nM 20719504
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Inhibition = 100 % 23327668
NPT1673 Individual Protein CaM kinase I gamma Homo sapiens Kd = 440 nM 15620251
NPT591 Individual Protein Glycogen synthase kinase-3 beta Homo sapiens Kd > 10000 nM 12105963
NPT3258 Individual Protein Mixed lineage kinase 7 Homo sapiens Kd > 10000 nM 18942825
NPT3111 Individual Protein Tyrosine-protein kinase Lyn Homo sapiens Kd = 270 nM 10579870
NPT1436 Individual Protein Focal adhesion kinase 1 Homo sapiens Kd = 440 nM 12350153
NPT36 Individual Protein Tyrosine-protein kinase SRC Homo sapiens Kd = 2100 nM 20594858
NPT2 Others Unspecified Activity = 0.961 21458279
NPT2 Others Unspecified Activity = 0.896 21458279
NPT2 Others Unspecified Activity = 0.951 21244021
NPT2 Others Unspecified Activity = 0.866 21244021
NPT2 Others Unspecified Activity = 0.933 21244021
NPT2364 Cell Line GP5d Homo sapiens Activity = 1.12 21458279
NPT2 Others Unspecified Activity = 0.938 21458279
NPT2347 Cell Line GMS-10 Homo sapiens Activity = 0.82 21458279
NPT2 Others Unspecified Activity = 1.12 21458279
NPT1975 Cell Line KS-1 Homo sapiens IC50 = 1692.47 nM 16499322
NPT379 Cell Line HOP-62 Homo sapiens IC50 = 4335.2 nM 15270564
NPT2100 Cell Line KG-1 IC50 = 6028.78 nM PubChem BioAssay data set
NPT2573 Individual Protein Vascular endothelial growth factor receptor 3 Homo sapiens IC50 = 8.9 nM 16038545
NPT1922 Cell Line COR-L88 Homo sapiens IC50 = 16001.2 nM 17291043
NPT4601 Cell Line EHEB Homo sapiens IC50 = 34119.26 nM 16417306
NPT3453 Individual Protein Cell division control protein 2 homolog Plasmodium falciparum (isolate 3D7) Kd > 10000 nM 16417306
NPT3393 Individual Protein PI4-kinase beta subunit Homo sapiens Kd > 10000 nM 25863432
NPT1703 Individual Protein cAMP-dependent protein kinase alpha-catalytic subunit Homo sapiens Kd > 10000 nM 25863432
NPT1699 Individual Protein 3-phosphoinositide dependent protein kinase-1 Homo sapiens Kd = 3500 nM 25728129
NPT3392 Individual Protein Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide Homo sapiens Kd > 10000 nM 25728129
NPT1265 Individual Protein Serine/threonine-protein kinase PIM1 Homo sapiens Kd > 10000 nM 25728129
NPT1445 Individual Protein PI3-kinase p110-gamma subunit Homo sapiens Kd > 10000 nM 25728129
NPT1442 Individual Protein Serine/threonine-protein kinase PAK 2 Homo sapiens Kd > 10000 nM 12932124
NPT3247 Individual Protein Serine/threonine-protein kinase PAK 3 Homo sapiens Kd = 16 nM 12932124
NPT3251 Individual Protein Serine/threonine-protein kinase PCTAIRE-3 Homo sapiens Kd = 1700 nM 12502331
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Kd = 0.075 nM 12502331
NPT1708 Individual Protein Serine/threonine-protein kinase 16 Homo sapiens Kd = 360 nM 14640510
NPT1658 Individual Protein Serine/threonine-protein kinase NEK2 Homo sapiens Kd = 500 nM 18507474
NPT1929 Cell Line CPC-N Homo sapiens IC50 = 8291.99 nM 18280170
NPT3240 Individual Protein Cyclin-dependent kinase 5 Homo sapiens Kd = 6900 nM 17190456
NPT2 Others Unspecified Kd > 10000 nM 8984156
NPT831 Individual Protein Serine/threonine-protein kinase PLK1 Homo sapiens Kd > 10000 nM 23688954
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 40 nM 23688954
NPT81 Cell Line A549 Homo sapiens IC50 = 18500 nM 23688954
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 11908959
NPT2136 Cell Line MDA-MB-134-VI Homo sapiens IC50 = 1607819.19 nM PubChem BioAssay data set
NPT1932 Cell Line CTV-1 Homo sapiens IC50 = 1727.51 nM PubChem BioAssay data set
NPT2460 Cell Line HCE-4 Homo sapiens IC50 = 3786.42 nM 19368377
NPT937 Cell Line NCI-H446 Homo sapiens IC50 = 27494.64 nM 16933872
NPT2158 Cell Line TE-441-T Homo sapiens IC50 = 94973.98 nM 16933872
NPT2051 Cell Line K5 Homo sapiens IC50 = 12298.52 nM 16933872
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 18.9 nM 10924160
NPT5297 Cell Line COLO Activity = 0.993 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 1.085 PubChem BioAssay data set
NPT90 Cell Line DU-145 Homo sapiens Activity = 0.931 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 1.119 PubChem BioAssay data set
NPT2287 Cell Line COR-L23 Homo sapiens Activity = 0.874 PubChem BioAssay data set
NPT579 Cell Line DLD-1 Homo sapiens Activity = 1.088 PubChem BioAssay data set
NPT1184 Cell Line Daoy Homo sapiens Activity = 1.132 PubChem BioAssay data set
NPT5297 Cell Line COLO Activity = 0.874 PubChem BioAssay data set
NPT1444 Individual Protein PI3-kinase p110-alpha subunit Homo sapiens Kd > 10000 nM 24582402
NPT3852 Cell Line COLO 320DM Homo sapiens AC50 = 1.464 24582402
NPT282 Individual Protein MAP kinase ERK2 Homo sapiens Kd > 10000 nM 23734744
NPT1435 Individual Protein Receptor protein-tyrosine kinase erbB-4 Homo sapiens Kd > 10000 nM 23734744
NPT3387 Individual Protein Receptor tyrosine-protein kinase erbB-3 Homo sapiens Kd > 10000 nM 23734744
NPT286 Individual Protein Receptor protein-tyrosine kinase erbB-2 Homo sapiens Kd > 10000 nM 23734744
NPT3359 Individual Protein Ephrin type-B receptor 3 Homo sapiens Kd > 10000 nM 23734744
NPT2941 Individual Protein Ephrin type-B receptor 2 Homo sapiens Kd > 10000 nM 23734744
NPT3361 Individual Protein Mitogen-activated protein kinase 4 Homo sapiens Kd > 10000 nM 23734744
NPT1692 Individual Protein Mitogen-activated protein kinase 6 Homo sapiens Kd > 10000 nM 23734744
NPT5297 Cell Line COLO Activity = 1.269 15620246
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.71 nM 8676127
NPT2 Others Unspecified IC50 = 18600 nM 17253856
NPT283 Individual Protein MAP kinase p38 alpha Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT81 Cell Line A549 Homo sapiens Activity = 15.81 % 18998696
NPT3255 Individual Protein Myosin light chain kinase family member 4 Homo sapiens Kd = 15 nM 17371044
NPT1611 Individual Protein Ribosomal protein S6 kinase 1 Homo sapiens Kd = 200 nM 17371044
NPT3107 Individual Protein Rho-associated protein kinase 2 Homo sapiens Kd = 140 nM 10.1584/jpestics.27.118
NPT3346 Individual Protein Cyclin-dependent kinase 7 Homo sapiens Kd = 330 nM 19860383
NPT3960 Individual Protein Bcr/Abl fusion protein Homo sapiens EC50 > 1000 nM 22671987
NPT2056 Cell Line MLMA Homo sapiens IC50 = 16990.75 nM 7853007
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens GI50 = 510 nM 11000019
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens GI50 = 2 nM 11000019
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens GI50 = 6 nM 11000019
NPT376 Cell Line A498 Homo sapiens IC50 = 719937.93 nM 26241103
NPT1974 Cell Line IST-SL2 Homo sapiens IC50 = 6125.19 nM 26241103
NPT1396 Cell Line NCI-H69 Homo sapiens IC50 = 200770.41 nM 26295595
NPT3279 Individual Protein Serine/threonine-protein kinase 11 Homo sapiens Kd = 38 nM PubChem BioAssay data set
NPT2111 Cell Line SF-126 Homo sapiens IC50 = 3061.98 nM PubChem BioAssay data set
NPT3279 Individual Protein Serine/threonine-protein kinase 11 Homo sapiens Kd = 38 nM 12502316
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Kd = 0.23 nM 9213587
NPT2 Others Unspecified Kd = 0.22 nM 19795842
NPT2 Others Unspecified Kd = 2.4 nM 20541427
NPT2573 Individual Protein Vascular endothelial growth factor receptor 3 Homo sapiens Kd = 50 nM 19379003
NPT1955 Cell Line A3-KAW Homo sapiens IC50 = 1625.46 nM 19606850
NPT2 Others Unspecified Kd = 1000 nM 19902967
NPT1717 Individual Protein Serine/threonine-protein kinase 25 Homo sapiens Kd = 290 nM 19902967
NPT2058 Cell Line NCI-H128 Homo sapiens IC50 = 13072.31 nM 15620248
NPT2 Others Unspecified Kd = 1200 nM 15620248
NPT737 Cell Line HUVEC Homo sapiens IC50 = 120 nM 19921834
NPT2022 Cell Line LS-513 Homo sapiens IC50 = 55877.51 nM 19921834
NPT3309 Individual Protein Leukocyte tyrosine kinase receptor Homo sapiens Kd = 1800 nM 19921834
NPT1997 Cell Line OS-RC-2 Homo sapiens IC50 = 4873.1 nM 14640511
NPT3257 Individual Protein Serine/threonine-protein kinase 32C Homo sapiens Kd > 10000 nM 9392880
NPT1940 Cell Line BE-13 Homo sapiens IC50 = 3231.11 nM 16872130
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens GI50 = 78 nM 10924160
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 10924160
NPT3296 Individual Protein Serine/threonine-protein kinase 33 Homo sapiens Kd = 17 nM 10425121
NPT1690 Individual Protein Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens Kd = 110 nM 10425121
NPT3434 Individual Protein SPS1/STE20-related protein kinase YSK4 Homo sapiens Kd = 17 nM 10425121
NPT3343 Individual Protein Uncharacterized aarF domain-containing protein kinase 4 Homo sapiens Kd > 10000 nM 10425121
NPT3299 Individual Protein Testis-specific serine/threonine-protein kinase 1 Homo sapiens Kd = 6300 nM 12608857
NPT3264 Individual Protein Serine/threonine-protein kinase RIO1 Homo sapiens Kd = 35 nM 12608857
NPT3318 Individual Protein MAP/microtubule affinity-regulating kinase 4 Homo sapiens Kd = 3600 nM 12608857
NPT3348 Individual Protein NUAK family SNF1-like kinase 2 Homo sapiens Kd = 150 nM 12608857
NPT3315 Individual Protein BR serine/threonine-protein kinase 1 Homo sapiens Kd = 3500 nM 12027764
NPT3248 Individual Protein CaM-kinase kinase alpha Homo sapiens Kd = 420 nM 12027764
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Inhibition = 90.1 % 17190457
NPT3212 Individual Protein Ephrin type-B receptor 1 Homo sapiens Kd = 960 nM 23434131
NPT2 Others Unspecified Activity = 0.834 10.1039/C1MD00003A
NPT3389 Individual Protein Mitogen-activated protein kinase kinase kinase 3 Homo sapiens Kd = 220 nM 15261294
NPT3408 Individual Protein Mitogen-activated protein kinase kinase kinase 13 Homo sapiens Kd = 95 nM 15261294
NPT3413 Individual Protein Mitogen-activated protein kinase kinase kinase 2 Homo sapiens Kd = 57 nM 15261294
NPT3111 Individual Protein Tyrosine-protein kinase Lyn Homo sapiens Kd = 270 nM 18077363
NPT1707 Individual Protein Serine/threonine-protein kinase 10 Homo sapiens Kd = 19 nM 18077363
NPT13 Individual Protein Tyrosine-protein kinase LCK Homo sapiens Kd = 230 nM 18327911
NPT2398 Cell Line MKN-7 Homo sapiens Activity = 1.14 PubChem BioAssay data set
NPT1158 Individual Protein NAD-dependent deacetylase sirtuin 2 Homo sapiens IC50 = 122700 nM PubChem BioAssay data set
NPT3240 Individual Protein Cyclin-dependent kinase 5 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT1437 Individual Protein Tyrosine-protein kinase FES Homo sapiens Kd = 960 nM PubChem BioAssay data set
NPT2573 Individual Protein Vascular endothelial growth factor receptor 3 Homo sapiens Inhibition = 81.3 % 10.6019/CHEMBL1201861
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens IC50 = 6.5 nM 10.6019/CHEMBL1201861
NPT3223 Individual Protein Phosphorylase kinase gamma subunit 2 Homo sapiens Kd = 5.9 nM 10.6019/CHEMBL1201861
NPT3371 Individual Protein Receptor-interacting serine/threonine-protein kinase 1 Homo sapiens Kd = 370 nM 10.6019/CHEMBL1201861
NPT1904 Cell Line ES3 Homo sapiens IC50 = 37500.38 nM 10.6019/CHEMBL1201861
NPT3374 Individual Protein Ribosomal protein S6 kinase alpha 4 Homo sapiens Kd = 2000 nM 10.6019/CHEMBL1201861
NPT1693 Individual Protein Serine/threonine-protein kinase MST4 Homo sapiens Kd = 340 nM 10.6019/CHEMBL1201861
NPT3464 Individual Protein Myelin transcription factor 1 Homo sapiens Activity < 5 % 10.6019/CHEMBL1201861
NPT2127 Cell Line NMC-G1 Homo sapiens IC50 = 27182.16 nM 10.6019/CHEMBL1201861
NPT14 Individual Protein Tyrosine-protein kinase FYN Homo sapiens Kd = 3900 nM 10.6019/CHEMBL1201861
NPT5022 Cell Line KP-N-RT-BM-1 Homo sapiens IC50 = 136501.69 nM 10.6019/CHEMBL1201861
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 = 172100 nM 11754602
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 139 nM 16933872
NPT1708 Individual Protein Serine/threonine-protein kinase 16 Homo sapiens Kd = 360 nM 17988094
NPT3281 Individual Protein Dual specificity mitogen-activated protein kinase kinase 3 Homo sapiens Kd > 10000 nM 21493075
NPT65 Cell Line HepG2 Homo sapiens IC50 = 13600 nM 12350171
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 0.22 nM PubChem BioAssay data set
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 0.41 nM PubChem BioAssay data set
NPT3316 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens Kd = 140 nM 26034885
NPT2 Others Unspecified Activity = 1.13 26034885
NPT1383 Cell Line A2058 Homo sapiens Activity = 1.118 20014777
NPT2 Others Unspecified Activity = 0.937 22850207
NPT2 Others Unspecified Activity = 1.139 22850207
NPT2331 Cell Line A-427 Homo sapiens Activity = 0.842 22850207
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 83.1 nM 22642560
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 18.9 nM 22642560
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 = 172.1 nM 22642560
NPT2 Others Unspecified IC50 = 1300 nM 22642560
NPT2192 Cell Line HEL Homo sapiens IC50 = 3480.05 nM 24359277
NPT2 Others Unspecified EC50 = 11000 nM 22901896
NPT1690 Individual Protein Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens Kd = 110 nM 16413779
NPT2501 Cell Line MEL-HO Homo sapiens Activity = 0.96 20112996
NPT1773 Cell Line ME-180 Homo sapiens Activity = 1.011 20038128
NPT2488 Cell Line MDA-MB-453 Homo sapiens Activity = 0.947 20038128
NPT2 Others Unspecified Activity = 0.825 20038128
NPT784 Cell Line MDA-MB-468 Homo sapiens Activity = 1.127 20028029
NPT82 Cell Line MDA-MB-231 Homo sapiens Activity = 1.583 20028029
NPT2 Others Unspecified Activity = 1.616 20028029
NPT2474 Cell Line MDA-MB-415 Homo sapiens Activity = 1.226 20028029
NPT737 Cell Line HUVEC Homo sapiens IC50 = 11.8 nM 20028029
NPT2161 Cell Line no-11 Homo sapiens IC50 = 7775.57 nM 20000781
NPT3357 Individual Protein Protein kinase N2 Homo sapiens Kd = 1300 nM 17844994
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 2.3 nM 17844994
NPT1265 Individual Protein Serine/threonine-protein kinase PIM1 Homo sapiens Kd > 10000 nM 17844994
NPT2134 Cell Line LB2518-MEL Homo sapiens IC50 = 528801.96 nM 11754615
NPT1698 Individual Protein Serine/threonine-protein kinase PCTAIRE-1 Homo sapiens Kd = 130 nM 16309320
NPT456 Cell Line OVCAR-4 Homo sapiens IC50 = 8503.51 nM 7769391
NPT32 Organism Mus musculus Mus musculus ED50 = 11 mg/kg 3735324
NPT1685 Individual Protein Casein kinase I gamma 2 Homo sapiens Kd = 110 nM 24901800
NPT2 Others Unspecified Activity = 1.153 24937209
NPT3273 Individual Protein Casein kinase II alpha (prime) Homo sapiens Kd = 370 nM 17542634
NPT3209 Individual Protein Mitogen-activated protein kinase kinase kinase 4 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT1712 Individual Protein TRAF2- and NCK-interacting kinase Homo sapiens Kd = 25 nM 25856683
NPT3323 Individual Protein Cell division cycle 2-like protein kinase 6 Homo sapiens Kd > 10000 nM 25856683
NPT3282 Individual Protein Maternal embryonic leucine zipper kinase Homo sapiens Kd = 350 nM 25856683
NPT1660 Individual Protein NUAK family SNF1-like kinase 1 Homo sapiens Kd = 48 nM 25856683
NPT3228 Individual Protein Adaptor-associated kinase Homo sapiens Kd = 11 nM 25856683
NPT3423 Individual Protein Serine/threonine-protein kinase ICK Homo sapiens Kd = 470 nM 25856683
NPT3290 Individual Protein Serine/threonine-protein kinase SIK2 Homo sapiens Kd = 580 nM 25856683
NPT3272 Individual Protein Tyrosine-protein kinase TXK Homo sapiens Kd > 10000 nM 14643343
NPT81 Cell Line A549 Homo sapiens IC50 = 7930 nM 19674905
NPT3442 Individual Protein Mitogen-activated protein kinase kinase kinase 7 Homo sapiens Kd = 93 nM 10.1016/S0960-894X(00)80646-0
NPT3416 Individual Protein STE20/SPS1-related proline-alanine-rich protein kinase Homo sapiens Kd = 140 nM 10.1016/S0960-894X(00)80646-0
NPT3296 Individual Protein Serine/threonine-protein kinase 33 Homo sapiens Kd = 17 nM 10.1016/S0960-894X(97)00071-1
NPT3431 Individual Protein Serine/threonine-protein kinase TAO1 Homo sapiens Kd = 890 nM 15056007
NPT3417 Individual Protein Serine/threonine-protein kinase TBK1 Homo sapiens Kd = 120 nM 15056007
NPT3427 Individual Protein Serine/threonine-protein kinase TAO3 Homo sapiens Kd = 210 nM 15056007
NPT3236 Individual Protein Death-associated protein kinase 2 Homo sapiens Kd = 150 nM 10465531
NPT3261 Individual Protein cAMP-dependent protein kinase beta-1 catalytic subunit Homo sapiens Kd > 10000 nM 10.1016/0960-894X(95)00300-I
NPT3207 Individual Protein c-Jun N-terminal kinase 3 Homo sapiens Kd > 10000 nM 9207945
NPT1905 Cell Line ES4 Homo sapiens IC50 = 2806.28 nM 12014968
NPT65 Cell Line HepG2 Homo sapiens Activity = 28 % 9554873
NPT2 Others Unspecified IC50 = 134 nM 7650675
NPT3354 Individual Protein Ephrin type-A receptor 1 Homo sapiens Kd > 10000 nM 10509925
NPT3272 Individual Protein Tyrosine-protein kinase TXK Homo sapiens Kd > 10000 nM 15658872
NPT3238 Individual Protein Dual specificity protein kinase TTK Homo sapiens Kd = 63 nM 15658872
NPT1449 Individual Protein Tyrosine-protein kinase SYK Homo sapiens Kd > 10000 nM 15482917
NPT1611 Individual Protein Ribosomal protein S6 kinase 1 Homo sapiens Kd = 48 nM 15482917
NPT3355 Individual Protein TGF-beta receptor type II Homo sapiens Kd > 10000 nM 15482917
NPT3351 Individual Protein Tyrosine-protein kinase TEC Homo sapiens Kd > 10000 nM 15482917
NPT3397 Individual Protein Cyclin-dependent kinase-like 5 Homo sapiens Kd > 10000 nM 15456257
NPT3396 Individual Protein Serine/threonine-protein kinase Nek4 Homo sapiens Kd > 10000 nM 15456257
NPT3229 Individual Protein ULK3 kinase Mus musculus Kd = 110 nM 18502124
NPT3289 Individual Protein Serine/threonine-protein kinase RIO3 Homo sapiens Kd = 3800 nM 14987069
NPT887 Individual Protein Protein kinase C theta Homo sapiens Kd = 4300 nM 16309315
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens IC50 = 8 nM 18558490
NPT306 Cell Line PC-3 Homo sapiens IC50 = 25100 nM 18816045
NPT3315 Individual Protein BR serine/threonine-protein kinase 1 Homo sapiens Kd = 3500 nM 18651771
NPT2094 Cell Line SKM-1 Homo sapiens IC50 = 113679.83 nM 19053514
NPT3020 Individual Protein Platelet-derived growth factor receptor alpha Homo sapiens Kd = 0.79 nM 19685913
NPT2019 Cell Line JVM-2 Homo sapiens IC50 = 28289.82 nM 20570625
NPT3245 Individual Protein Tyrosine kinase non-receptor protein 2 Homo sapiens Kd = 2200 nM 20185316
NPT3273 Individual Protein Casein kinase II alpha (prime) Homo sapiens Kd = 160 nM 16936720
NPT3342 Individual Protein Epithelial discoidin domain-containing receptor 1 Homo sapiens Kd = 2000 nM 20619511
NPT3338 Individual Protein Myosin IIIA Homo sapiens Kd > 10000 nM DrugMatrix in vitro pharmacology data
NPT3340 Individual Protein Serine/threonine-protein kinase Nek1 Homo sapiens Kd > 10000 nM DrugMatrix in vitro pharmacology data
NPT3327 Individual Protein Mitogen-activated protein kinase kinase kinase 10 Homo sapiens Kd > 10000 nM DrugMatrix in vitro pharmacology data
NPT3329 Individual Protein Serine/threonine-protein kinase MRCK-A Homo sapiens Kd > 10000 nM DrugMatrix in vitro pharmacology data
NPT3390 Individual Protein Macrophage-stimulating protein receptor Homo sapiens Kd > 10000 nM DrugMatrix in vitro pharmacology data
NPT1918 Cell Line DMS-79 Homo sapiens IC50 = 288357.2 nM DrugMatrix in vitro pharmacology data
NPT1696 Individual Protein Serine/threonine-protein kinase PAK7 Homo sapiens Kd = 640 nM DrugMatrix in vitro pharmacology data
NPT2046 Cell Line EVSA-T Homo sapiens IC50 = 17048.46 nM DrugMatrix in vitro pharmacology data
NPT98 Individual Protein HERG Homo sapiens IC50 = 10000 nM 22682920
NPT2413 Cell Line PC-14 Homo sapiens Activity = 0.841 23305918
NPT306 Cell Line PC-3 Homo sapiens Activity = 1.014 23305918
NPT2 Others Unspecified Activity = 1.16 23305918
NPT2 Others Unspecified Activity = 0.953 23305918
NPT2 Others Unspecified Activity = 1.193 23305918
NPT2 Others Unspecified Activity = 1.107 23305918
NPT2 Others Unspecified Activity = 1.118 23305918
NPT2396 Cell Line KYSE-510 Homo sapiens Activity = 0.882 10.6019/CHEMBL1201861
NPT3320 Individual Protein Proto-oncogene tyrosine-protein kinase MER Homo sapiens Activity = 100 % 10.6019/CHEMBL1201861
NPT5021 Cell Line CP67-MEL Homo sapiens IC50 = 132542.98 nM 10.6019/CHEMBL1201861
NPT1701 Individual Protein Serine/threonine-protein kinase PIM3 Homo sapiens Kd = 2400 nM 10.6019/CHEMBL1201861
NPT370 Cell Line NCI-H23 Homo sapiens IC50 = 31106.26 nM 10.6019/CHEMBL1201861
NPT1649 Cell Line MV4-11 Homo sapiens Activity = 0.5 % 10.6019/CHEMBL1201861
NPT301 Individual Protein Vascular endothelial growth factor receptor 1 Homo sapiens Inhibition = 87.1 % 10.6019/CHEMBL1201861
NPT2 Others Unspecified IC50 = 23000 nM 10.6019/CHEMBL1201861
NPT3345 Individual Protein Cyclin-dependent kinase 3 Homo sapiens Kd > 10000 nM 23849207
NPT3287 Individual Protein Activin receptor type-1 Homo sapiens Kd > 10000 nM 23999041
NPT2 Others Unspecified Activity = 0.944 24095018
NPT2 Others Unspecified Activity = 0.858 24095018
NPT2443 Cell Line SNU-449 Homo sapiens Activity = 1.101 24095018
NPT4783 Cell Line SNU-398 Homo sapiens Activity = 1.005 24095019
NPT2090 Cell Line SNU-16 Homo sapiens Activity = 0.931 24095019
NPT2 Others Unspecified Activity = 1.071 24095019
NPT2 Others Unspecified Activity = 1.164 24012378
NPT2 Others Unspecified Activity = 1.107 24012378
NPT2091 Cell Line SNU-5 Homo sapiens Activity = 0.894 24012378
NPT2030 Cell Line U-698-M Homo sapiens IC50 = 189794.52 nM Open TG-GATES in vivo data: Hematology
NPT1371 Individual Protein Cyclin-dependent kinase 2 Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Hematology
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 180 nM Open TG-GATES in vivo data: Biochemistry
NPT1694 Individual Protein Serine/threonine-protein kinase OSR1 Homo sapiens Kd = 530 nM Open TG-GATES in vivo data: Biochemistry
NPT3107 Individual Protein Rho-associated protein kinase 2 Homo sapiens Kd = 140 nM Open TG-GATES in vivo data: Biochemistry
NPT1721 Individual Protein Death-associated protein kinase 1 Homo sapiens Kd = 120 nM Open TG-GATES in vivo data: Biochemistry
NPT1446 Individual Protein PI3-kinase p110-delta subunit Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Biochemistry
NPT3246 Individual Protein Tyrosine-protein kinase JAK2 Homo sapiens Kd = 410 nM Open TG-GATES in vivo data: Biochemistry
NPT3262 Individual Protein Serine/threonine-protein kinase PRKX Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Biochemistry
NPT116 Cell Line HL-60 Homo sapiens IC50 = 4210.65 nM Open TG-GATES in vivo data: Biochemistry
NPT1442 Individual Protein Serine/threonine-protein kinase PAK 2 Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Biochemistry
NPT1712 Individual Protein TRAF2- and NCK-interacting kinase Homo sapiens Kd = 25 nM Open TG-GATES in vivo data: Biochemistry
NPT2180 Cell Line LC-2-ad Homo sapiens IC50 = 1114.07 nM Open TG-GATES in vivo data: Biochemistry
NPT3257 Individual Protein Serine/threonine-protein kinase 32C Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Biochemistry
NPT1663 Individual Protein Tyrosine-protein kinase YES Homo sapiens Kd = 120 nM Open TG-GATES in vivo data: Biochemistry
NPT3434 Individual Protein SPS1/STE20-related protein kinase YSK4 Homo sapiens Kd = 17 nM Open TG-GATES in vivo data: Biochemistry
NPT3341 Individual Protein Serine/threonine-protein kinase Nek5 Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Biochemistry
NPT1649 Cell Line MV4-11 Homo sapiens IC50 = 9 nM Open TG-GATES in vivo data: Pathology
NPT1933 Cell Line CW-2 Homo sapiens IC50 = 383859.65 nM Open TG-GATES in vivo data: Pathology
NPT3234 Individual Protein Ribosomal protein S6 kinase alpha 2 Homo sapiens Kd = 58 nM Open TG-GATES in vivo data: Pathology
NPT3223 Individual Protein Phosphorylase kinase gamma subunit 2 Homo sapiens Kd = 39 nM Open TG-GATES in vivo data: Pathology
NPT3280 Individual Protein Serine/threonine-protein kinase c-TAK1 Homo sapiens Kd = 640 nM Open TG-GATES in vivo data: Pathology
NPT1706 Individual Protein Serine/threonine-protein kinase 2 Homo sapiens Kd = 81 nM Open TG-GATES in vivo data: Pathology
NPT1613 Individual Protein Ribosomal protein S6 kinase alpha 5 Homo sapiens Kd = 250 nM Open TG-GATES in vivo data: Pathology
NPT1705 Individual Protein Ribosomal protein S6 kinase alpha 3 Homo sapiens Kd = 55 nM Open TG-GATES in vivo data: Pathology
NPT1709 Individual Protein Serine/threonine-protein kinase 17A Homo sapiens Kd = 21 nM Open TG-GATES in vivo data: Pathology
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 0.99 nM Open TG-GATES in vivo data: Organ Weight
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 4.3 nM Open TG-GATES in vivo data: Organ Weight
NPT3358 Individual Protein Serine/threonine-protein kinase PLK3 Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Organ Weight
NPT1683 Individual Protein Dual specificity protein kinase CLK3 Homo sapiens Kd > 10000 nM Open TG-GATES in vivo data: Organ Weight
NPT1682 Individual Protein Dual specificity protein kinase CLK2 Homo sapiens Kd = 20 nM Open TG-GATES in vivo data: Organ Weight
NPT3344 Individual Protein BR serine/threonine-protein kinase 2 Homo sapiens Kd = 1100 nM Open TG-GATES in vivo data: Organ Weight
NPT3297 Individual Protein Non-receptor tyrosine-protein kinase TNK1 Homo sapiens Kd = 680 nM Open TG-GATES in vivo data: Organ Weight
NPT1960 Cell Line BV-173 Homo sapiens IC50 = 2336.6 nM Open TG-GATES in vivo data: Organ Weight
NPT139 Cell Line HT-29 Homo sapiens IC50 = 1300 nM Open TG-GATES in vivo data: Organ Weight
NPT83 Cell Line MCF7 Homo sapiens GI < 10 % DrugMatrix in vivo data: Pathology
NPT2144 Cell Line TE-12 Homo sapiens IC50 = 804.55 nM DrugMatrix in vivo data: Pathology
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Potency 2133.1 nM DrugMatrix in vivo data: Hematology
NPT3222 Individual Protein AMP-activated protein kinase, alpha-1 subunit Homo sapiens Kd = 19 nM DrugMatrix in vivo data: Hematology
NPT3361 Individual Protein Mitogen-activated protein kinase 4 Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Hematology
NPT1962 Cell Line DB Homo sapiens IC50 = 311668.15 nM DrugMatrix in vivo data: Hematology
NPT2092 Cell Line NEC8 Homo sapiens IC50 = 12688.74 nM DrugMatrix in vivo data: Hematology
NPT3335 Individual Protein Serine/threonine-protein kinase DCLK1 Homo sapiens Kd = 370 nM 24422592
NPT3353 Individual Protein TGF-beta receptor type I Homo sapiens Kd > 10000 nM 24424132
NPT2008 Cell Line NB69 Homo sapiens IC50 = 290226.31 nM 15646539
NPT3436 Individual Protein Serine/threonine-protein kinase 35 Homo sapiens Kd = 1300 nM 25059503
NPT3288 Individual Protein Interleukin-1 receptor-associated kinase 3 Homo sapiens Kd = 940 nM 25644672
NPT3331 Individual Protein Serine/threonine-protein kinase MST2 Homo sapiens Kd = 56 nM 25899335
NPT3228 Individual Protein Adaptor-associated kinase Homo sapiens Kd = 11 nM 25495422
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 18900 nM 26361737
NPT3206 Individual Protein Serine/threonine-protein kinase Aurora-C Homo sapiens Kd = 310 nM 22694318
NPT81 Cell Line A549 Homo sapiens IC50 = 6610 nM 19754130
NPT2152 Cell Line NTERA-2-cl-D1 Homo sapiens IC50 = 17857.2 nM 19754130
NPT3224 Individual Protein Phosphorylase kinase gamma subunit 1 Homo sapiens Kd = 5.5 nM PubChem BioAssay data set
NPT2 Others Unspecified EC50 > 1000 nM 18557621
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 37 nM 21652215
NPT2311 Cell Line Calu-3 Homo sapiens Activity = 0.944 24689881
NPT2149 Cell Line MZ1-PC Homo sapiens IC50 = 7303.89 nM 24689881
NPT2 Others Unspecified Activity = 0.945 24836069
NPT2 Others Unspecified Activity = 0.807 24836069
NPT2 Others Unspecified Activity = 1.282 24836069
NPT2 Others Unspecified Activity = 1.126 24836069
NPT2 Others Unspecified Activity = 1.193 24836069
NPT2 Others Unspecified Activity = 1.271 24836069
NPT5027 Cell Line Hs 683 Homo sapiens Activity = 1.139 24836069
NPT2 Others Unspecified Activity = 1 24836069
NPT1481 Individual Protein Fibroblast growth factor receptor 2 Homo sapiens Kd = 570 nM 17319723
NPT1480 Individual Protein Fibroblast growth factor receptor 1 Homo sapiens Kd = 520 nM 12713411
NPT1436 Individual Protein Focal adhesion kinase 1 Homo sapiens Kd = 440 nM 24679044
NPT1890 Individual Protein Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens Kd = 600 nM 9873631
NPT301 Individual Protein Vascular endothelial growth factor receptor 1 Homo sapiens Kd = 1.8 nM 9873631
NPT3112 Individual Protein Tyrosine-protein kinase FGR Homo sapiens Kd = 270 nM 9873631
NPT3227 Individual Protein Fibroblast growth factor receptor 3 Homo sapiens Kd = 290 nM 9873631
NPT1432 Individual Protein Serine/threonine-protein kinase Aurora-A Homo sapiens Kd = 1700 nM PubChem BioAssay data set
NPT3344 Individual Protein BR serine/threonine-protein kinase 2 Homo sapiens Kd = 1100 nM PubChem BioAssay data set
NPT2280 Cell Line A704 Homo sapiens IC50 = 17990.43 nM 19072209
NPT3448 Individual Protein Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens IC50 = 28 nM 6361218
NPT3421 Individual Protein Hormonally up-regulated neu tumor-associated kinase Homo sapiens Kd = 500 nM 16872140
NPT3419 Individual Protein Serine/threonine-protein kinase SRPK3 Homo sapiens Kd = 59 nM 16872140
NPT3420 Individual Protein Eukaryotic translation initiation factor 2-alpha kinase 1 Homo sapiens Kd > 10000 nM 16872140
NPT1657 Individual Protein Serine/threonine-protein kinase NEK6 Homo sapiens Kd > 10000 nM 20558060
NPT1706 Individual Protein Serine/threonine-protein kinase 2 Homo sapiens Kd = 56 nM 20558060
NPT3422 Individual Protein Serine/threonine-protein kinase ULK2 Homo sapiens Kd = 13 nM 20558060
NPT3267 Individual Protein Macrophage colony stimulating factor receptor Homo sapiens Kd = 2 nM 23237974
NPT1956 Cell Line COLO-668 Homo sapiens IC50 = 30791.97 nM 25611215
NPT831 Individual Protein Serine/threonine-protein kinase PLK1 Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT1931 Cell Line BB30-HNC Homo sapiens IC50 = 2223.75 nM PubChem BioAssay data set
NPT2506 Cell Line RO82-W-1 Homo sapiens Activity = 0.952 14664515
NPT2010 Cell Line NCI-H716 Homo sapiens IC50 = 133966.8 nM 15974580
NPT3242 Individual Protein LIM domain kinase 1 Homo sapiens Kd > 10000 nM 15974580
NPT2035 Cell Line NCCIT Homo sapiens IC50 = 8717.45 nM 25729554
NPT65 Cell Line HepG2 Homo sapiens Activity = 68 % 22276679
NPT3234 Individual Protein Ribosomal protein S6 kinase alpha 2 Homo sapiens Kd = 17 nM 18950230
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 = 172100 nM 23398362
NPT5 Individual Protein Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Homo sapiens Potency 17782.8 nM 23398362
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 39 nM 23398362
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 0.47 nM 23398362
NPT3334 Individual Protein Citron Rho-interacting kinase Homo sapiens Kd = 3900 nM 23398362
NPT1649 Cell Line MV4-11 Homo sapiens IC50 = 4.3 nM 23398362
NPT1658 Individual Protein Serine/threonine-protein kinase NEK2 Homo sapiens Kd = 1400 nM 16413779
NPT3233 Individual Protein Serine/threonine-protein kinase 38-like Homo sapiens Kd = 970 nM 16413779
NPT2 Others Unspecified Kd = 1200 nM 16413779
NPT2 Others Unspecified Kd = 4700 nM 16413779
NPT3326 Individual Protein Mitogen-activated protein kinase kinase kinase 9 Homo sapiens Kd = 3400 nM 16413779
NPT3339 Individual Protein Myosin-IIIB Homo sapiens Kd = 4500 nM 16413779
NPT3328 Individual Protein Mitogen-activated protein kinase kinase kinase 11 Homo sapiens Kd = 1300 nM 16413779
NPT591 Individual Protein Glycogen synthase kinase-3 beta Homo sapiens Kd > 10000 nM 2746258
NPT3205 Individual Protein Tyrosine-protein kinase HCK Homo sapiens Kd = 880 nM 2746258
NPT2573 Individual Protein Vascular endothelial growth factor receptor 3 Homo sapiens Kd = 50 nM 2746258
NPT3204 Individual Protein Tyrosine-protein kinase FRK Homo sapiens Kd = 530 nM 2746258
NPT1437 Individual Protein Tyrosine-protein kinase FES Homo sapiens Kd = 960 nM 23734701
NPT301 Individual Protein Vascular endothelial growth factor receptor 1 Homo sapiens Kd = 1.8 nM 17461599
NPT3266 Individual Protein Casein kinase I delta Homo sapiens Kd = 15 nM 10843580
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Kd = 1.5 nM 25993619
NPT3242 Individual Protein LIM domain kinase 1 Homo sapiens Kd > 10000 nM 25993619
NPT2 Others Unspecified IC50 = 30 nM 11429258
NPT3329 Individual Protein Serine/threonine-protein kinase MRCK-A Homo sapiens Kd > 10000 nM 23145909
NPT81 Cell Line A549 Homo sapiens IC50 = 9100 nM 20192247
NPT831 Individual Protein Serine/threonine-protein kinase PLK1 Homo sapiens Kd > 10000 nM 11520220
NPT3249 Individual Protein Tyrosine- and threonine-specific cdc2-inhibitory kinase Homo sapiens Kd > 10000 nM 11520220
NPT881 Individual Protein Protein kinase C delta Homo sapiens Kd > 10000 nM 11520220
NPT3124 Individual Protein Protein kinase C eta Homo sapiens Kd > 10000 nM 22724531
NPT761 Individual Protein Protein kinase C epsilon Homo sapiens Kd > 10000 nM 22724531
NPT3368 Individual Protein cGMP-dependent protein kinase 2 Homo sapiens Kd > 10000 nM 22724531
NPT3378 Individual Protein Serine/threonine-protein kinase SIK3 Homo sapiens Kd > 10000 nM 21741249
NPT2 Others Unspecified Activity = 1.134 25211032
NPT1659 Individual Protein Tyrosine-protein kinase receptor UFO Homo sapiens Activity = 99.9 % PubChem BioAssay data set
NPT83 Cell Line MCF7 Homo sapiens IC50 = 10500 nM 12444675
NPT1649 Cell Line MV4-11 Homo sapiens IC50 = 3 nM 11908966
NPT1434 Individual Protein Serine/threonine-protein kinase B-raf Homo sapiens Kd > 10000 nM 22537362
NPT3261 Individual Protein cAMP-dependent protein kinase beta-1 catalytic subunit Homo sapiens Kd > 10000 nM 21090801
NPT182 Individual Protein Protein kinase C alpha Homo sapiens Kd > 10000 nM 21090801
NPT2 Others Unspecified Kd > 10000 nM 21090801
NPT1446 Individual Protein PI3-kinase p110-delta subunit Homo sapiens Kd > 10000 nM 21090801
NPT3376 Individual Protein PI3-kinase p110-beta subunit Homo sapiens Kd > 10000 nM 21090801
NPT3393 Individual Protein PI4-kinase beta subunit Homo sapiens Kd > 10000 nM 21090801
NPT1445 Individual Protein PI3-kinase p110-gamma subunit Homo sapiens Kd > 10000 nM 21090801
NPT3255 Individual Protein Myosin light chain kinase family member 4 Homo sapiens Kd = 15 nM 26230970
NPT3212 Individual Protein Ephrin type-B receptor 1 Homo sapiens Kd = 480 nM 26290401
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 12200 nM 26290401
NPT940 Individual Protein Serine/threonine-protein kinase mTOR Homo sapiens Kd > 10000 nM 26290401
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 720 nM 26290401
NPT407 Cell Line COLO 205 Homo sapiens Activity = 1.318 20000781
NPT5297 Cell Line COLO Activity = 0.897 20000781
NPT5297 Cell Line COLO Activity = 1.074 20795741
NPT5297 Cell Line COLO Activity = 0.777 20795741
NPT1695 Individual Protein Serine/threonine-protein kinase PAK 4 Homo sapiens Kd = 2300 nM 20055477
NPT2576 Individual Protein Tyrosine-protein kinase TIE-2 Homo sapiens Kd > 10000 nM 19425589
NPT1659 Individual Protein Tyrosine-protein kinase receptor UFO Homo sapiens Activity = 100 % 11277757
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 380 nM 24576210
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.21 nM 23265253
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 10.6 nM 9868159
NPT3901 Tissue Chorioallantoic membrane Gallus gallus IC50 = 1.3 nM 20411974
NPT2 Others Unspecified IC50 > 50000 nM 18950230
NPT1686 Individual Protein Casein kinase I isoform gamma-3 Homo sapiens Kd = 240 nM 22168134
NPT1697 Individual Protein Serine/threonine-protein kinase PAK6 Homo sapiens Kd = 2400 nM 17844994
NPT1674 Individual Protein CaM kinase II alpha Homo sapiens Kd = 370 nM 17844994
NPT2 Others Unspecified GI50 = 5 nM 17844994
NPT1649 Cell Line MV4-11 Homo sapiens GI50 = 1 nM 17844994
NPT2 Others Unspecified GI50 = 1 nM 17844994
NPT3241 Individual Protein Serine/threonine-protein kinase NEK9 Homo sapiens Kd > 10000 nM 23944995
NPT1441 Individual Protein MAP kinase-activated protein kinase 2 Homo sapiens Kd > 10000 nM 23944995
NPT3326 Individual Protein Mitogen-activated protein kinase kinase kinase 9 Homo sapiens Kd = 3400 nM 23944995
NPT3243 Individual Protein myosin light chain kinase 2 Homo sapiens Kd = 49 nM 23944995
NPT3435 Individual Protein Serine/threonine-protein kinase pknB Mycobacterium tuberculosis Kd = 87 nM 23944995
NPT3337 Individual Protein Serine/threonine-protein kinase DCLK3 Homo sapiens Kd = 110 nM 23944963
NPT2626 Individual Protein Myosin light chain kinase, smooth muscle Homo sapiens Kd = 280 nM 23944963
NPT3321 Individual Protein PITSLRE serine/threonine-protein kinase CDC2L1 Homo sapiens Kd > 10000 nM 23944963
NPT3436 Individual Protein Serine/threonine-protein kinase 35 Homo sapiens Kd = 1300 nM 23944963
NPT1973 Cell Line IST-SL1 Homo sapiens IC50 = 8024.17 nM 20738103
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 0.47 nM 16420055
NPT453 Cell Line HT-1080 Homo sapiens Activity = 1.023 17665951
NPT2 Others Unspecified Activity = 0.759 12542353
NPT2157 Cell Line SUP-T1 Homo sapiens IC50 = 181296.9 nM 9599250
NPT3348 Individual Protein NUAK family SNF1-like kinase 2 Homo sapiens Kd = 150 nM 19848432
NPT3222 Individual Protein AMP-activated protein kinase, alpha-1 subunit Homo sapiens Kd = 19 nM 1578486
NPT1913 Cell Line DJM-1 Homo sapiens IC50 = 91562.43 nM 17672504
NPT83 Cell Line MCF7 Homo sapiens Inhibition = 94 % 19618898
NPT2101 Cell Line LAN-6 Homo sapiens IC50 = 14245.73 nM 26147490
NPT386 Cell Line KM12 Homo sapiens IC50 = 350.14 nM 21856162
NPT1702 Individual Protein Serine/threonine-protein kinase PLK4 Homo sapiens Kd = 190 nM 21761866
NPT3263 Individual Protein Protein tyrosine kinase 2 beta Homo sapiens Kd = 82 nM 15332848
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 12932125
NPT1903 Cell Line ES5 Homo sapiens IC50 = 24734.92 nM 16038541
NPT3218 Individual Protein Ephrin type-A receptor 4 Homo sapiens Kd > 10000 nM 21784631
NPT3209 Individual Protein Mitogen-activated protein kinase kinase kinase 4 Homo sapiens Kd = 4800 nM 17964170
NPT1431 Individual Protein Mitogen-activated protein kinase kinase kinase 5 Homo sapiens Kd > 10000 nM 19170519
NPT3278 Individual Protein LIM domain kinase 2 Homo sapiens Kd > 10000 nM 19170519
NPT3333 Individual Protein Muscle, skeletal receptor tyrosine protein kinase Homo sapiens Kd = 490 nM 19170519
NPT2546 Individual Protein Serine/threonine-protein kinase AKT3 Homo sapiens Kd > 10000 nM 19170519
NPT1439 Individual Protein Tyrosine-protein kinase ITK/TSK Homo sapiens Kd = 13 nM 19170519
NPT3410 Individual Protein Serine/threonine-protein kinase MAK Homo sapiens Kd > 10000 nM 19256529
NPT3411 Individual Protein Mitogen-activated protein kinase kinase kinase 1 Homo sapiens Kd > 10000 nM 19256529
NPT3409 Individual Protein Homeodomain-interacting protein kinase 3 Homo sapiens Kd = 41 nM 19256529
NPT3366 Individual Protein Protein kinase C nu Homo sapiens Kd = 280 nM 19256529
NPT3106 Individual Protein Ribosomal protein S6 kinase alpha 1 Homo sapiens Kd = 140 nM PubChem BioAssay data set
NPT2 Others Unspecified Kd > 10000 nM PubChem BioAssay data set
NPT3215 Individual Protein Tyrosine-protein kinase BRK Homo sapiens Kd > 10000 nM PubChem BioAssay data set
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 2.3 nM 15060738
NPT2075 Cell Line NCI-H2196 Homo sapiens IC50 = 108550.34 nM 22409377
NPT2406 Cell Line HCC1395 Homo sapiens Activity = 0.908 21195622
NPT2 Others Unspecified Activity = 1.113 23062825
NPT2426 Cell Line HCC1806 Homo sapiens Activity = 1.048 23062825
NPT2 Others Unspecified Activity = 1.299 22305612
NPT1884 Cell Line HCC1937 Homo sapiens Activity = 1.444 24900772
NPT2446 Cell Line HCC38 Homo sapiens Activity = 1.165 24900772
NPT2 Others Unspecified Activity = 0.987 24900772
NPT2 Others Unspecified Activity = 1.027 15646539
NPT2 Others Unspecified Activity = 0.912 15646539
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 5.7 nM 12502332
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 5.5 nM 12502332
NPT3020 Individual Protein Platelet-derived growth factor receptor alpha Homo sapiens Inhibition = 68.4 % 24571273
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Inhibition = 80.2 % 24571273
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Inhibition = 81.8 % 24571273
NPT301 Individual Protein Vascular endothelial growth factor receptor 1 Homo sapiens Inhibition = 66.6 % 24571273
NPT3207 Individual Protein c-Jun N-terminal kinase 3 Homo sapiens Kd = 4300 nM 24571273
NPT1616 Individual Protein MAP kinase p38 beta Homo sapiens Kd > 10000 nM 24571273
NPT1426 Individual Protein c-Jun N-terminal kinase 1 Homo sapiens Kd > 10000 nM 24571273
NPT3362 Individual Protein Mitogen-activated protein kinase 7 Homo sapiens Kd = 9900 nM 24571273
NPT1692 Individual Protein Mitogen-activated protein kinase 6 Homo sapiens Kd > 10000 nM 24571273
NPT3361 Individual Protein Mitogen-activated protein kinase 4 Homo sapiens Kd > 10000 nM 24571273
NPT281 Individual Protein MAP kinase ERK1 Homo sapiens Kd > 10000 nM 24571273
NPT3364 Individual Protein Protein kinase C mu Homo sapiens Kd = 310 nM 24571273
NPT3394 Individual Protein Protein kinase C iota Homo sapiens Kd > 10000 nM 24571273
NPT3261 Individual Protein cAMP-dependent protein kinase beta-1 catalytic subunit Homo sapiens Kd > 10000 nM 24571273
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.28 nM 24571273
NPT2052 Cell Line KALS-1 Homo sapiens IC50 = 16593.13 nM 24571273
NPT2114 Cell Line EW-3 Homo sapiens IC50 = 6432.07 nM 24571273
NPT1481 Individual Protein Fibroblast growth factor receptor 2 Homo sapiens Kd = 530 nM 27173802
NPT2107 Cell Line PSN1 Homo sapiens IC50 = 1506.76 nM PubChem BioAssay data set
NPT1688 Individual Protein Myotonin-protein kinase Homo sapiens Kd > 10000 nM 19261477
NPT2626 Individual Protein Myosin light chain kinase, smooth muscle Homo sapiens Kd = 280 nM 12443782
NPT3360 Individual Protein Tubulin alpha-1 chain Rattus norvegicus Kd > 10000 nM 11212126
NPT3374 Individual Protein Ribosomal protein S6 kinase alpha 4 Homo sapiens Kd = 2000 nM 10406648
NPT1671 Individual Protein AMP-activated protein kinase, alpha-2 subunit Homo sapiens Kd = 89 nM 3279208
NPT3339 Individual Protein Myosin-IIIB Homo sapiens Kd = 4500 nM 9371235
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 9371235
NPT1661 Individual Protein ALK tyrosine kinase receptor Homo sapiens IC50 = 2300 nM 12570385
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens Activity = 96 % 10691682
NPT111 Cell Line K562 Homo sapiens IC50 = 2410 nM 11495593
NPT1683 Individual Protein Dual specificity protein kinase CLK3 Homo sapiens Kd > 10000 nM 10649984
NPT3254 Individual Protein Ribosomal protein S6 kinase alpha 6 Homo sapiens Kd > 10000 nM 15357968
NPT3254 Individual Protein Ribosomal protein S6 kinase alpha 6 Homo sapiens Kd = 2400 nM 15357968
NPT3236 Individual Protein Death-associated protein kinase 2 Homo sapiens Kd = 150 nM 15267234
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 22.3 nM 17070063
NPT3722 Cell Line 4T1 Mus musculus IC50 = 16 nM 17070063
NPT576 Cell Line DMS-114 Homo sapiens IC50 = 77138.15 nM 18278859
NPT6509 Individual Protein G protein-coupled receptor kinase 5 Mus musculus Activity = 53.2 % 17404003
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Potency 2685.5 nM 19231182
NPT1481 Individual Protein Fibroblast growth factor receptor 2 Homo sapiens Inhibition = 61.8 % 19284751
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 2110 nM 19284751
NPT4143 Protein Complex Platelet-derived growth factor receptor Mus musculus IC50 = 8 nM 18774792
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 2 nM 18788725
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 80 nM 19081726
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 > 20000 nM 19084416
NPT1480 Individual Protein Fibroblast growth factor receptor 1 Homo sapiens IC50 = 2900 nM 19084416
NPT4143 Protein Complex Platelet-derived growth factor receptor Mus musculus IC50 = 10 nM 19084416
NPT2 Others Unspecified IC50 = 50 nM 19084416
NPT2026 Cell Line Ramos-2G6-4C10 Homo sapiens IC50 = 11265.02 nM 8450319
NPT2209 Cell Line MFH-ino Homo sapiens IC50 = 150608.09 nM 18805693
NPT1612 Individual Protein MAP kinase-activated protein kinase 5 Homo sapiens Kd > 10000 nM 18514971
NPT1911 Cell Line C2BBe1 Homo sapiens IC50 = 208215.17 nM 19339178
NPT2 Others Unspecified Kd = 180 nM 17562796
NPT2 Others Unspecified Potency 32196.8 nM 19091562
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens GI50 = 53 nM 19091562
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens GI50 = 23 nM 19256501
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens GI50 = 20 nM 19256501
NPT1992 Cell Line KURAMOCHI Homo sapiens IC50 = 93087.14 nM 19191551
NPT3373 Individual Protein Proto-oncogene tyrosine-protein kinase ROS Homo sapiens Kd > 10000 nM 20131843
NPT1712 Individual Protein TRAF2- and NCK-interacting kinase Homo sapiens Kd = 25 nM 19949061
NPT1630 Individual Protein CaM kinase II beta Homo sapiens Kd = 3200 nM 20828199
NPT139 Cell Line HT-29 Homo sapiens GI50 = 1600 nM 21190857
NPT394 Cell Line EKVX Homo sapiens GI50 = 7900 nM 21190857
NPT403 Cell Line UACC-257 Homo sapiens GI50 = 4000 nM 21190857
NPT383 Cell Line SNB-19 Homo sapiens GI50 = 10000 nM 21190857
NPT384 Cell Line TK-10 Homo sapiens GI50 = 6300 nM 21123074
NPT2573 Individual Protein Vascular endothelial growth factor receptor 3 Homo sapiens Kd = 50 nM 19307369
NPT2055 Cell Line ML-2 Homo sapiens IC50 = 2635.12 nM 19307369
NPT2 Others Unspecified Kd = 0.41 nM 19171802
NPT2 Others Unspecified Kd = 0.21 nM 19171802
NPT3308 Individual Protein Serine/threonine-protein kinase LATS2 Homo sapiens Kd = 460 nM 19171802
NPT3307 Individual Protein Serine/threonine-protein kinase LATS1 Homo sapiens Kd = 630 nM 19171802
NPT3251 Individual Protein Serine/threonine-protein kinase PCTAIRE-3 Homo sapiens Kd = 1700 nM 19171802
NPT3286 Individual Protein Insulin receptor-related protein Homo sapiens Kd = 430 nM 18955514
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens Inhibition = 84.8 % 20937779
NPT1820 Cell Line NCI-H1650 Homo sapiens IC50 = 29017.58 nM 21500839
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 4510 nM 21966980
NPT2131 Cell Line WSU-NHL Homo sapiens IC50 = 375216.05 nM 22464685
NPT3343 Individual Protein Uncharacterized aarF domain-containing protein kinase 4 Homo sapiens Kd > 10000 nM 24900509
NPT3306 Individual Protein Serine/threonine-protein kinase MRCK gamma Homo sapiens Kd > 10000 nM 22541068
NPT2 Others Unspecified IC50 = 1300 nM 24900481
NPT3289 Individual Protein Serine/threonine-protein kinase RIO3 Homo sapiens Kd = 3800 nM 10.1007/s00044-011-9694-1
NPT1924 Cell Line AM-38 Homo sapiens IC50 = 197528.13 nM 10.1007/s00044-011-9694-1
NPT3362 Individual Protein Mitogen-activated protein kinase 7 Homo sapiens Kd > 10000 nM 10.1007/s00044-008-9089-0
NPT2079 Cell Line EW-12 Homo sapiens IC50 = 1452216.08 nM 23586757
NPT3244 Individual Protein Tyrosine-protein kinase FER Homo sapiens Kd = 1100 nM 23880082
NPT1437 Individual Protein Tyrosine-protein kinase FES Homo sapiens Kd = 960 nM 23880082
NPT2 Others Unspecified Kd = 1400 nM 23880082
NPT2147 Cell Line LB647-SCLC Homo sapiens IC50 = 161260.81 nM 23837878
NPT3367 Individual Protein cGMP-dependent protein kinase 1 beta Homo sapiens Kd > 10000 nM 24978605
NPT3243 Individual Protein myosin light chain kinase 2 Homo sapiens Kd = 57 nM 25633870
NPT1942 Cell Line CESS Homo sapiens IC50 = 7104.38 nM 25906200
NPT1988 Cell Line SW684 Homo sapiens IC50 = 895464.88 nM 25593097
NPT3312 Individual Protein Tyrosine-protein kinase BLK Homo sapiens Kd = 65 nM 26421992
NPT286 Individual Protein Receptor protein-tyrosine kinase erbB-2 Homo sapiens Kd > 10000 nM 27212070
NPT445 Individual Protein Peripheral myelin protein 22 Rattus norvegicus Potency 10181.5 nM 23621813
NPT1674 Individual Protein CaM kinase II alpha Homo sapiens Kd = 80 nM 11975486
NPT1436 Individual Protein Focal adhesion kinase 1 Homo sapiens Kd = 440 nM 11975486
NPT3263 Individual Protein Protein tyrosine kinase 2 beta Homo sapiens Kd = 82 nM 11975486
NPT1676 Individual Protein CaM kinase II gamma Homo sapiens Kd = 690 nM 11975486
NPT3444 Individual Protein Homeodomain-interacting protein kinase 1 Homo sapiens Kd = 55 nM 11975486
NPT3443 Individual Protein Serine/threonine-protein kinase Nek11 Homo sapiens Kd > 10000 nM 11975486
NPT3445 Individual Protein Serine/threonine-protein kinase NIM1 Homo sapiens Kd = 850 nM 21159516
NPT14 Individual Protein Tyrosine-protein kinase FYN Homo sapiens Kd = 520 nM 21159516
NPT3257 Individual Protein Serine/threonine-protein kinase 32C Homo sapiens Kd > 10000 nM 11575942
NPT3349 Individual Protein Serine/threonine-protein kinase SIK1 Homo sapiens Kd = 3200 nM 11575942
NPT36 Individual Protein Tyrosine-protein kinase SRC Homo sapiens Kd = 2100 nM 22506638
NPT2 Others Unspecified Activity = 1.124 11325232
NPT2 Others Unspecified Activity = 0.951 11325232
NPT2307 Cell Line 769-P Homo sapiens Activity = 1.102 11325232
NPT2303 Cell Line 647-V Homo sapiens Activity = 0.952 11170674
NPT2 Others Unspecified Activity = 0.613 9599259
NPT2312 Cell Line 8305C Homo sapiens Activity = 0.951 9599259
NPT2038 Cell Line NCI-H748 Homo sapiens IC50 = 479317.88 nM 23327794
NPT2 Others Unspecified Activity = 0.93 10691710
NPT2469 Cell Line G-401 Homo sapiens Activity = 0.506 10543891
NPT1436 Individual Protein Focal adhesion kinase 1 Homo sapiens Kd = 610 nM 25894905
NPT1721 Individual Protein Death-associated protein kinase 1 Homo sapiens Kd = 120 nM 25763602
NPT2173 Cell Line TE-6 Homo sapiens IC50 = 107684.43 nM 9036182
NPT2 Others Unspecified IC50 = 19600 nM 22647719
NPT3302 Individual Protein Ankyrin repeat and protein kinase domain-containing protein 1 Homo sapiens Kd = 310 nM 11678651
NPT3248 Individual Protein CaM-kinase kinase alpha Homo sapiens Kd = 420 nM 23249297
NPT2 Others Unspecified Activity = 0.952 23398362
NPT3256 Individual Protein Serine/threonine-protein kinase WEE1 Homo sapiens Kd = 1100 nM 23398362
NPT2054 Cell Line LU-165 Homo sapiens IC50 = 401593.35 nM 23398362
NPT1700 Individual Protein Serine/threonine-protein kinase PIM2 Homo sapiens Kd = 5000 nM 23398362
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 18 nM 23398362
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 22 nM 23398362
NPT32 Organism Mus musculus Mus musculus ED50 = 9 mg/kg 23398362
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Inhibition = 82.1 % 23398362
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 4710 nM 23398362
NPT2 Others Unspecified IC50 = 220 nM 10579870
NPT139 Cell Line HT-29 Homo sapiens IC50 = 4700 nM 17190454
NPT3365 Individual Protein Serine/threonine-protein kinase D2 Homo sapiens Kd = 380 nM 25264585
NPT3426 Individual Protein Serine/threonine-protein kinase TAO2 Homo sapiens Kd > 10000 nM 22204643
NPT3425 Individual Protein Interleukin-1 receptor-associated kinase 4 Homo sapiens Kd = 66 nM 22204643
NPT3298 Individual Protein Serine/threonine-protein kinase TNNI3K Homo sapiens Kd > 10000 nM 26670413
NPT2941 Individual Protein Ephrin type-B receptor 2 Homo sapiens Kd > 10000 nM 25710081
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 0.47 nM 24164245
NPT3259 Individual Protein Tyrosine-protein kinase ZAP-70 Homo sapiens Kd > 10000 nM 19105653
NPT2202 Cell Line TGBC1TKB Homo sapiens IC50 = 12001.96 nM 21420296
NPT2409 Cell Line LU-99A Homo sapiens Activity = 0.929 10780915
NPT2 Others Unspecified GI50 = 1700 nM 21856049
NPT2095 Cell Line TALL-1 Homo sapiens IC50 = 8183.84 nM 25856683
NPT3215 Individual Protein Tyrosine-protein kinase BRK Homo sapiens Kd > 10000 nM 21865046
NPT5297 Cell Line COLO Activity = 0.919 24273638
NPT5297 Cell Line COLO Activity = 1.176 24273638
NPT5297 Cell Line COLO Activity = 0.985 24273638
NPT2 Others Unspecified Activity = 0.875 24273638
NPT2 Others Unspecified Activity = 0.951 24273638
NPT2193 Cell Line IM-9 Homo sapiens IC50 = 1350 nM 24273638
NPT2 Others Unspecified Kd = 5.8 nM 18242997
NPT2 Others Unspecified Kd = 8.7 nM 8988597
NPT2 Others Unspecified Kd = 19 nM 18032042
NPT3264 Individual Protein Serine/threonine-protein kinase RIO1 Homo sapiens Kd = 35 nM 18217716
NPT2 Others Unspecified Survival = 2.6 % 10869203
NPT3317 Individual Protein Serine/threonine-protein kinase MARK1 Homo sapiens Kd = 1200 nM 10869203
NPT3813 Individual Protein Tyrosine-protein kinase SRC Gallus gallus IC50 = 555 nM 19666224
NPT2206 Cell Line IST-MES1 Homo sapiens IC50 = 13672.93 nM 19344127
NPT3276 Individual Protein Tyrosine-protein kinase TYK2 Homo sapiens Kd = 1600 nM 10654416
NPT3276 Individual Protein Tyrosine-protein kinase TYK2 Homo sapiens Kd = 360 nM 20014777
NPT3256 Individual Protein Serine/threonine-protein kinase WEE1 Homo sapiens Kd = 1100 nM 20014777
NPT3398 Individual Protein Serine/threonine-protein kinase ULK1 Homo sapiens Kd = 23 nM 20014777
NPT3332 Individual Protein Serine/threonine-protein kinase 24 Homo sapiens Kd = 63 nM 20014777
NPT3399 Individual Protein Dual-specificity tyrosine-phosphorylation regulated kinase 2 Homo sapiens Kd = 680 nM 20014777
NPT1432 Individual Protein Serine/threonine-protein kinase Aurora-A Homo sapiens Kd = 1700 nM 20014777
NPT3357 Individual Protein Protein kinase N2 Homo sapiens Kd = 1300 nM 24645629
NPT3253 Individual Protein Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Homo sapiens Kd = 5400 nM 24645629
NPT3283 Individual Protein MAP kinase-interacting serine/threonine-protein kinase MNK1 Homo sapiens Kd > 10000 nM 24645629
NPT1661 Individual Protein ALK tyrosine kinase receptor Homo sapiens Kd = 170 nM 15217281
NPT3284 Individual Protein Serine/threonine-protein kinase NEK7 Homo sapiens Kd = 4100 nM 23354070
NPT2031 Cell Line ES8 Homo sapiens IC50 = 146113.1 nM 2853205
NPT3216 Individual Protein Ephrin type-A receptor 8 Homo sapiens Kd > 10000 nM 25245917
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Kd = 0.21 nM 25089583
NPT3233 Individual Protein Serine/threonine-protein kinase 38-like Homo sapiens Kd = 1500 nM 15620246
NPT3232 Individual Protein CaM kinase I alpha Homo sapiens Kd = 2000 nM 15620246
NPT3386 Individual Protein Interleukin-1 receptor-associated kinase 1 Homo sapiens Kd = 14 nM 21970540
NPT981 Individual Protein Inhibitor of nuclear factor kappa B kinase beta subunit Homo sapiens Kd > 10000 nM 21970540
NPT1430 Individual Protein Serine/threonine-protein kinase AKT2 Homo sapiens Kd = 2700 nM 21970540
NPT3294 Individual Protein Activin receptor type-2A Homo sapiens Kd > 10000 nM 21970540
NPT1685 Individual Protein Casein kinase I gamma 2 Homo sapiens Kd = 110 nM 1686898
NPT982 Individual Protein Inhibitor of nuclear factor kappa B kinase alpha subunit Homo sapiens Kd = 520 nM 1686898
NPT1890 Individual Protein Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens Kd = 600 nM 11087583
NPT1687 Individual Protein Death-associated protein kinase 3 Homo sapiens Kd = 22 nM 11087583
NPT3312 Individual Protein Tyrosine-protein kinase BLK Homo sapiens Kd = 65 nM 17655260
NPT1659 Individual Protein Tyrosine-protein kinase receptor UFO Homo sapiens Kd = 9 nM 17655260
NPT2083 Cell Line KARPAS-422 Homo sapiens IC50 = 7572.06 nM PubChem BioAssay data set
NPT2039 Cell Line NCI-H82 Homo sapiens IC50 = 7378.5 nM 19256529
NPT2108 Cell Line QIMR-WIL Homo sapiens IC50 = 3633.91 nM 9358642
NPT1442 Individual Protein Serine/threonine-protein kinase PAK 2 Homo sapiens Kd > 10000 nM 8864235
NPT3120 Individual Protein Serine/threonine-protein kinase PAK 1 Homo sapiens Kd > 10000 nM 8864235
NPT3285 Individual Protein Serine/threonine protein kinase NLK Homo sapiens Kd > 10000 nM 8988595
NPT3241 Individual Protein Serine/threonine-protein kinase NEK9 Homo sapiens Kd > 10000 nM 15787450
NPT1657 Individual Protein Serine/threonine-protein kinase NEK6 Homo sapiens Kd > 10000 nM 15787450
NPT3341 Individual Protein Serine/threonine-protein kinase Nek5 Homo sapiens Kd > 10000 nM 15787450
NPT1615 Individual Protein MAP kinase p38 gamma Homo sapiens Kd > 10000 nM 15787450
NPT1614 Individual Protein MAP kinase p38 delta Homo sapiens Kd > 10000 nM 15787450
NPT1616 Individual Protein MAP kinase p38 beta Homo sapiens Kd > 10000 nM 14738377
NPT283 Individual Protein MAP kinase p38 alpha Homo sapiens Kd > 10000 nM 11754614
NPT2 Others Unspecified IC50 = 100 nM 20353194
NPT139 Cell Line HT-29 Homo sapiens IC50 = 330 nM 11076547
NPT2 Others Unspecified IC50 = 80 nM 11076547
NPT3770 Protein Complex Platelet-derived growth factor receptor Homo sapiens IC50 = 80 nM 11076547
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Ki = 9 nM 12193010
NPT3347 Individual Protein Cyclin-dependent kinase 9 Homo sapiens Kd > 10000 nM 17343407
NPT283 Individual Protein MAP kinase p38 alpha Homo sapiens Kd > 10000 nM 22672981
NPT3285 Individual Protein Serine/threonine protein kinase NLK Homo sapiens Kd > 10000 nM 22304303
NPT2 Others Unspecified Activity = 1.144 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.958 PubChem BioAssay data set
NPT2453 Cell Line RCM-1 Homo sapiens Activity = 0.83 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.9 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.99 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.855 22019229
NPT2 Others Unspecified Activity = 1.047 22019229
NPT2 Others Unspecified Activity = 0.85 PubChem BioAssay data set
NPT2467 Cell Line RERF-LC-MS Homo sapiens Activity = 0.983 22858297
NPT2210 Cell Line NB10 Homo sapiens IC50 = 1602160 nM 20420415
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 270 nM 18640837
NPT3232 Individual Protein CaM kinase I alpha Homo sapiens Kd = 970 nM 8450319
NPT3278 Individual Protein LIM domain kinase 2 Homo sapiens Kd > 10000 nM 8289059
NPT3205 Individual Protein Tyrosine-protein kinase HCK Homo sapiens Kd = 880 nM 8289059
NPT2184 Cell Line NCI-H510A Homo sapiens IC50 = 24127.78 nM 21130542
NPT3303 Individual Protein Discoidin domain-containing receptor 2 Homo sapiens Kd = 2900 nM 21420296
NPT2 Others Unspecified Activity = 1.184 12088423
NPT3302 Individual Protein Ankyrin repeat and protein kinase domain-containing protein 1 Homo sapiens Kd = 310 nM 12088423
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 21572583
NPT3316 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens Kd = 140 nM 12617894
NPT2088 Cell Line MOLT-16 Homo sapiens IC50 = 631.32 nM PubChem BioAssay data set
NPT3351 Individual Protein Tyrosine-protein kinase TEC Homo sapiens Kd > 10000 nM 23747224
NPT3230 Individual Protein Serine/threonine-protein kinase 17B Homo sapiens Kd = 220 nM 23747224
NPT3432 Individual Protein Homeodomain-interacting protein kinase 2 Homo sapiens Kd = 31 nM 17315964
NPT3409 Individual Protein Homeodomain-interacting protein kinase 3 Homo sapiens Kd = 41 nM 17315964
NPT3205 Individual Protein Tyrosine-protein kinase HCK Homo sapiens Kd = 880 nM 17315964
NPT3439 Individual Protein Homeodomain-interacting protein kinase 4 Homo sapiens Kd = 160 nM 17315964
NPT3310 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens Kd = 16 nM 19053513
NPT3421 Individual Protein Hormonally up-regulated neu tumor-associated kinase Homo sapiens Kd = 500 nM 22548480
NPT3423 Individual Protein Serine/threonine-protein kinase ICK Homo sapiens Kd = 470 nM 22548480
NPT2 Others Unspecified Activity = 1.044 22548480
NPT2 Others Unspecified Activity = 0.946 22548480
NPT2387 Cell Line KYSE-410 Homo sapiens Activity = 0.889 16643039
NPT2395 Cell Line KYSE-450 Homo sapiens Activity = 1.016 16643039
NPT2386 Cell Line KYSE-270 Homo sapiens Activity = 1.047 16643039
NPT2 Others Unspecified Activity = 1.121 16643039
NPT2 Others Unspecified Activity = 0.687 7473578
NPT2 Others Unspecified Activity = 1.028 7473578
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Inhibition = 82.1 % 18345641
NPT3020 Individual Protein Platelet-derived growth factor receptor alpha Homo sapiens Inhibition = 93 % PubChem BioAssay data set
NPT3214 Individual Protein Tyrosine-protein kinase ABL2 Homo sapiens Kd = 1200 nM 12762798
NPT2047 Cell Line HC-1 Homo sapiens IC50 = 5432.91 nM 18798681
NPT2014 Cell Line SW872 Homo sapiens IC50 = 8347.58 nM 11754603
NPT1613 Individual Protein Ribosomal protein S6 kinase alpha 5 Homo sapiens Kd = 1700 nM 8277313
NPT1709 Individual Protein Serine/threonine-protein kinase 17A Homo sapiens Kd = 1 nM 8277313
NPT3307 Individual Protein Serine/threonine-protein kinase LATS1 Homo sapiens Kd = 630 nM 8277313
NPT3274 Individual Protein Dual specificity tyrosine-phosphorylation-regulated kinase 1B Homo sapiens Kd = 2300 nM 8277313
NPT3406 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 2 Homo sapiens Kd = 33 nM 8277313
NPT1705 Individual Protein Ribosomal protein S6 kinase alpha 3 Homo sapiens Kd = 580 nM 8277313
NPT3407 Individual Protein Mitogen-activated protein kinase kinase kinase 6 Homo sapiens Kd > 10000 nM 8277313
NPT111 Cell Line K562 Homo sapiens IC50 = 2410 nM 12398537
NPT2116 Cell Line HCC2218 Homo sapiens IC50 = 600384.33 nM 16643033
NPT3304 Individual Protein Serine/threonine-protein kinase receptor R3 Homo sapiens Kd > 10000 nM 7473578
NPT3294 Individual Protein Activin receptor type-2A Homo sapiens Kd > 10000 nM 19028102
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 18900 nM 8759170
NPT2 Others Unspecified Activity = 1.084 8759170
NPT3205 Individual Protein Tyrosine-protein kinase HCK Homo sapiens Kd = 3300 nM 9584401
NPT3315 Individual Protein BR serine/threonine-protein kinase 1 Homo sapiens Kd = 3500 nM 19453174
NPT1430 Individual Protein Serine/threonine-protein kinase AKT2 Homo sapiens Kd = 2700 nM 19453174
NPT3214 Individual Protein Tyrosine-protein kinase ABL2 Homo sapiens Kd = 1000 nM 19453174
NPT3269 Individual Protein Serine/threonine-protein kinase tousled-like 2 Homo sapiens Kd = 330 nM 10091706
NPT3231 Individual Protein Dual specificity protein kinase CLK4 Homo sapiens Kd = 80 nM 17261619
NPT3236 Individual Protein Death-associated protein kinase 2 Homo sapiens Kd = 470 nM 17261619
NPT1681 Individual Protein Dual specificty protein kinase CLK1 Homo sapiens Kd = 100 nM 17261619
NPT1682 Individual Protein Dual specificity protein kinase CLK2 Homo sapiens Kd = 190 nM 17261619
NPT1674 Individual Protein CaM kinase II alpha Homo sapiens Kd = 370 nM 17261619
NPT1676 Individual Protein CaM kinase II gamma Homo sapiens Kd = 760 nM 17261619
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 870 nM 17261619
NPT3210 Individual Protein BMP-2-inducible protein kinase Homo sapiens Kd = 38 nM 17261619
NPT1687 Individual Protein Death-associated protein kinase 3 Homo sapiens Kd = 300 nM 17261619
NPT3211 Individual Protein Ephrin type-A receptor 7 Homo sapiens Kd = 710 nM 17261619
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 11 nM 17261619
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 2.4 nM 17261619
NPT3230 Individual Protein Serine/threonine-protein kinase 17B Homo sapiens Kd = 110 nM 17261619
NPT1679 Individual Protein Cyclin-dependent kinase-like 1 Homo sapiens Kd > 10000 nM 17261619
NPT1661 Individual Protein ALK tyrosine kinase receptor Homo sapiens Kd = 170 nM 17261619
NPT3293 Individual Protein Activin receptor type-1B Homo sapiens Kd > 10000 nM 17261619
NPT1434 Individual Protein Serine/threonine-protein kinase B-raf Homo sapiens Kd > 10000 nM 17261619
NPT3313 Individual Protein Bone morphogenetic protein receptor type-1A Homo sapiens Kd > 10000 nM 17261619
NPT3113 Individual Protein Tyrosine-protein kinase CSK Homo sapiens Kd > 10000 nM 17261619
NPT81 Cell Line A549 Homo sapiens IC50 = 12350 nM 17846127
NPT3358 Individual Protein Serine/threonine-protein kinase PLK3 Homo sapiens Kd > 10000 nM 17562800
NPT2187 Cell Line RL95-2 Homo sapiens IC50 = 2111.37 nM 17682106
NPT3262 Individual Protein Serine/threonine-protein kinase PRKX Homo sapiens Kd > 10000 nM 17724156
NPT3307 Individual Protein Serine/threonine-protein kinase LATS1 Homo sapiens Kd = 630 nM 17785513
NPT3210 Individual Protein BMP-2-inducible protein kinase Homo sapiens Kd = 5.5 nM 20047913
NPT2563 Individual Protein Tankyrase-2 Homo sapiens Kd = 8900 nM 18644957
NPT3271 Individual Protein NT-3 growth factor receptor Homo sapiens Kd = 5100 nM 18644957
NPT3299 Individual Protein Testis-specific serine/threonine-protein kinase 1 Homo sapiens Kd = 6300 nM 18644957
NPT3282 Individual Protein Maternal embryonic leucine zipper kinase Homo sapiens Kd = 350 nM 18809939
NPT65 Cell Line HepG2 Homo sapiens IC50 = 13240 nM 18809939
NPT2160 Cell Line no-10 Homo sapiens IC50 = 21026.45 nM 18809945
NPT1659 Individual Protein Tyrosine-protein kinase receptor UFO Homo sapiens IC50 = 9 nM 18505851
NPT2034 Cell Line LU-134-A Homo sapiens IC50 = 52334.88 nM 18378715
NPT1899 Cell Line DSH1 Homo sapiens IC50 = 507141.98 nM 20970332
NPT13 Individual Protein Tyrosine-protein kinase LCK Homo sapiens Kd = 1200 nM 19015330
NPT2124 Cell Line MRK-nu-1 Homo sapiens IC50 = 104990.83 nM 19188377
NPT491 Individual Protein Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Kd = 130 nM 19349512
NPT371 Cell Line UO-31 Homo sapiens Activity = 0.867 18591275
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 4.3 nM 18591275
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 80 nM 20921306
NPT2 Others Unspecified EC50 > 1000 nM 21397370
NPT2050 Cell Line K052 Homo sapiens IC50 = 2402.02 nM DrugMatrix in vitro pharmacology data
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.37 nM DrugMatrix in vitro pharmacology data
NPT1944 Cell Line D-247MG Homo sapiens IC50 = 103799.28 nM DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified Activity = 1.04 22194678
NPT2138 Cell Line MSTO-211H Homo sapiens Activity = 0.953 22194678
NPT6387 Cell Line MOG-G-UVW Homo sapiens Activity = 0.857 22194678
NPT2 Others Unspecified Activity = 0.857 22194678
NPT2723 Cell Line MKN-74 Homo sapiens Activity = 0.799 22194678
NPT2 Others Unspecified Activity = 0.979 22194678
NPT1097 Cell Line MKN-45 Homo sapiens Activity = 1.445 22194678
NPT1659 Individual Protein Tyrosine-protein kinase receptor UFO Homo sapiens Kd = 9 nM 22194678
NPT3206 Individual Protein Serine/threonine-protein kinase Aurora-C Homo sapiens Kd = 220 nM 22194678
NPT1433 Individual Protein Serine/threonine-protein kinase Aurora-B Homo sapiens Kd = 380 nM 22194678
NPT1660 Individual Protein NUAK family SNF1-like kinase 1 Homo sapiens Kd = 48 nM 22194678
NPT1671 Individual Protein AMP-activated protein kinase, alpha-2 subunit Homo sapiens Kd = 89 nM 22194678
NPT2008 Cell Line NB69 Homo sapiens Activity = 0.905 22194678
NPT1969 Cell Line TGW Homo sapiens IC50 = 13327.57 nM 10.1007/s00044-011-9729-7
NPT3321 Individual Protein PITSLRE serine/threonine-protein kinase CDC2L1 Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Pathology
NPT2006 Cell Line MHH-PREB-1 Homo sapiens IC50 = 5323.12 nM DrugMatrix in vivo data: Biochemistry
NPT3277 Individual Protein Tyrosine-protein kinase receptor TYRO3 Homo sapiens Kd = 49 nM DrugMatrix in vivo data: Hematology
NPT1715 Individual Protein Serine/threonine-protein kinase VRK2 Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Hematology
NPT3124 Individual Protein Protein kinase C eta Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Hematology
NPT3357 Individual Protein Protein kinase N2 Homo sapiens Kd = 1300 nM DrugMatrix in vivo data: Hematology
NPT887 Individual Protein Protein kinase C theta Homo sapiens Kd = 4300 nM DrugMatrix in vivo data: Hematology
NPT3367 Individual Protein cGMP-dependent protein kinase 1 beta Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Hematology
NPT3368 Individual Protein cGMP-dependent protein kinase 2 Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Hematology
NPT3331 Individual Protein Serine/threonine-protein kinase MST2 Homo sapiens Kd = 56 nM DrugMatrix in vivo data: Hematology
NPT1711 Individual Protein Serine/threonine-protein kinase MST1 Homo sapiens Kd = 19 nM DrugMatrix in vivo data: Hematology
NPT3239 Individual Protein Nerve growth factor receptor Trk-A Homo sapiens Kd = 100 nM 26854381
NPT1700 Individual Protein Serine/threonine-protein kinase PIM2 Homo sapiens Kd > 10000 nM 23268694
NPT1265 Individual Protein Serine/threonine-protein kinase PIM1 Homo sapiens Kd > 10000 nM 23268694
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 83100 nM 18973387
NPT1676 Individual Protein CaM kinase II gamma Homo sapiens Kd = 690 nM 24697496
NPT3276 Individual Protein Tyrosine-protein kinase TYK2 Homo sapiens Kd = 1600 nM 25510639
NPT2166 Cell Line LB831-BLC Homo sapiens IC50 = 32384.31 nM 23206866
NPT3225 Individual Protein Ephrin type-A receptor 2 Homo sapiens Kd > 10000 nM 21167711
NPT3225 Individual Protein Ephrin type-A receptor 2 Homo sapiens Kd > 10000 nM 21696954
NPT1656 Individual Protein Protein kinase N1 Homo sapiens Kd = 710 nM 22472691
NPT2 Others Unspecified Ratio = 10 22801644
NPT737 Cell Line HUVEC Homo sapiens IC50 = 800 nM 15104480
NPT3318 Individual Protein MAP/microtubule affinity-regulating kinase 4 Homo sapiens Kd = 3600 nM 18095654
NPT3379 Individual Protein Mitogen-activated protein kinase kinase kinase 15 Homo sapiens Kd = 1300 nM 9644066
NPT1434 Individual Protein Serine/threonine-protein kinase B-raf Homo sapiens Kd > 10000 nM 18243700
NPT2 Others Unspecified IC50 = 1100 nM 18243700
NPT5297 Cell Line COLO Activity = 0.964 21875800
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Kd = 0.075 nM 25226228
NPT1673 Individual Protein CaM kinase I gamma Homo sapiens Kd = 990 nM 11312930
NPT3255 Individual Protein Myosin light chain kinase family member 4 Homo sapiens Kd = 15 nM 11312930
NPT3301 Individual Protein Eukaryotic translation initiation factor 2-alpha kinase 4 Homo sapiens Kd = 180 nM 11312930
NPT3245 Individual Protein Tyrosine kinase non-receptor protein 2 Homo sapiens Kd = 8900 nM 11312930
NPT3239 Individual Protein Nerve growth factor receptor Trk-A Homo sapiens Kd = 100 nM 11312930
NPT3234 Individual Protein Ribosomal protein S6 kinase alpha 2 Homo sapiens Kd = 8400 nM 11312930
NPT3374 Individual Protein Ribosomal protein S6 kinase alpha 4 Homo sapiens Kd = 96 nM 11312930
NPT1695 Individual Protein Serine/threonine-protein kinase PAK 4 Homo sapiens Kd = 2300 nM 11312930
NPT3380 Individual Protein Serine/threonine-protein kinase SBK1 Homo sapiens Kd = 200 nM 11312930
NPT301 Individual Protein Vascular endothelial growth factor receptor 1 Homo sapiens Inhibition = 88 % 20078073
NPT3259 Individual Protein Tyrosine-protein kinase ZAP-70 Homo sapiens Kd > 10000 nM 16420055
NPT1908 Cell Line EC-GI-10 Homo sapiens IC50 = 1951442.26 nM 11714611
NPT2084 Cell Line KARPAS-45 Homo sapiens IC50 = 2494.46 nM 10843574
NPT3308 Individual Protein Serine/threonine-protein kinase LATS2 Homo sapiens Kd = 460 nM 21084196
NPT301 Individual Protein Vascular endothelial growth factor receptor 1 Homo sapiens IC50 = 1 nM 7807122
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens IC50 > 5000 nM 25946116
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 185 nM 25946116
NPT1698 Individual Protein Serine/threonine-protein kinase PCTAIRE-1 Homo sapiens Kd = 150 nM 25946116
NPT3211 Individual Protein Ephrin type-A receptor 7 Homo sapiens Kd = 710 nM PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.846 PubChem BioAssay data set
NPT2 Others Unspecified Activity = 0.987 PubChem BioAssay data set
NPT2317 Cell Line ChaGo-K-1 Homo sapiens Activity = 0.771 PubChem BioAssay data set
NPT1313 Cell Line Capan-2 Homo sapiens Activity = 1.242 PubChem BioAssay data set
NPT2309 Cell Line CAPAN-1 Homo sapiens Activity = 1.238 PubChem BioAssay data set
NPT4605 Cell Line CCF-STTG1 Homo sapiens Activity = 0.929 PubChem BioAssay data set
NPT2 Others Unspecified IC50 = 830 nM 15043442
NPT2 Others Unspecified IC50 = 2300 nM 2832544
NPT2466 Cell Line NCI-H358 Homo sapiens Activity = 0.951 24387347
NPT2476 Cell Line NCI-H441 Homo sapiens Activity = 1.035 24387347
NPT2450 Cell Line NCI-H2452 Homo sapiens Activity = 1.198 24387347
NPT2 Others Unspecified Activity = 1.218 24387347
NPT455 Cell Line NCI-H522 Homo sapiens Activity = 0.849 16989522
NPT2335 Cell Line NCI-H596 Activity = 0.809 17432904
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 0.86 17432904
NPT2342 Cell Line NCI-H630 Homo sapiens Activity = 1.023 12662097
NPT5522 Cell Line NCI-H647 Activity = 1.01 12662097
NPT1959 Cell Line A4-Fuk Homo sapiens IC50 = 1341.41 nM 12662097
NPT3366 Individual Protein Protein kinase C nu Homo sapiens Kd = 280 nM 24359277
NPT2023 Cell Line NB7 Homo sapiens IC50 = 27922.87 nM 13678412
NPT1963 Cell Line Becker Homo sapiens IC50 = 645339.8 nM PubChem BioAssay data set
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 18 nM DrugMatrix in vitro pharmacology data
NPT3336 Individual Protein Serine/threonine-protein kinase DCLK2 Homo sapiens Kd = 2700 nM DrugMatrix in vitro pharmacology data
NPT2045 Cell Line ETK-1 Homo sapiens IC50 = 1285.8 nM DrugMatrix in vitro pharmacology data
NPT3112 Individual Protein Tyrosine-protein kinase FGR Homo sapiens Kd = 270 nM DrugMatrix in vitro pharmacology data
NPT385 Cell Line SR Homo sapiens IC50 = 1545.72 nM 22194678
NPT1703 Individual Protein cAMP-dependent protein kinase alpha-catalytic subunit Homo sapiens Kd > 10000 nM DrugMatrix in vivo data: Hematology
NPT3226 Individual Protein Casein kinase I epsilon Homo sapiens Kd = 13 nM 18763827
NPT323 Cell Line SW-620 Homo sapiens Activity = 1.119 10843594
NPT2360 Cell Line SW756 Homo sapiens Activity = 1.033 23848163
NPT3295 Individual Protein Activin receptor type-2B Homo sapiens Kd > 10000 nM 11000026
NPT2 Others Unspecified IC50 = 23000 nM 17896816
NPT2381 Cell Line SW900 Homo sapiens Activity = 0.865 9083483
NPT2 Others Unspecified IC50 = 185 nM PubChem BioAssay data set
NPT1982 Cell Line NCI-H1963 Homo sapiens IC50 = 403364.25 nM 18278869
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens Kd = 19 nM 12027740
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 12200 nM 15043442
NPT929 Cell Line BC1 cell line IC50 = 7248.12 nM 7277393
NPT3311 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 3 Homo sapiens Kd = 180 nM 11844673
NPT2546 Individual Protein Serine/threonine-protein kinase AKT3 Homo sapiens Kd > 10000 nM 10891117
NPT2197 Cell Line NCI-H1770 Homo sapiens IC50 = 14536.94 nM 18467007
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens IC50 = 264 nM 18467007
NPT2011 Cell Line NCI-H719 Homo sapiens IC50 = 16916.14 nM 16643040
NPT2036 Cell Line NCI-H1092 Homo sapiens IC50 = 342184.82 nM 18070971
NPT1663 Individual Protein Tyrosine-protein kinase YES Homo sapiens Kd = 120 nM 18070971
NPT3356 Individual Protein Tyrosine-protein kinase receptor Tie-1 Homo sapiens Kd = 3900 nM 18070971
NPT761 Individual Protein Protein kinase C epsilon Homo sapiens Kd > 10000 nM 18070971
NPT13 Individual Protein Tyrosine-protein kinase LCK Homo sapiens Kd = 230 nM 18070971
NPT36 Individual Protein Tyrosine-protein kinase SRC Homo sapiens Kd = 2100 nM 18070971
NPT592 Individual Protein Rho-associated protein kinase 1 Homo sapiens Kd = 460 nM 18070971
NPT3244 Individual Protein Tyrosine-protein kinase FER Homo sapiens Kd = 1100 nM 18070971
NPT3217 Individual Protein Ephrin type-A receptor 3 Homo sapiens Kd = 2100 nM 18070971
NPT3221 Individual Protein Serine/threonine-protein kinase GAK Homo sapiens Kd = 20 nM 18070971
NPT3112 Individual Protein Tyrosine-protein kinase FGR Homo sapiens Kd = 270 nM 18070971
NPT2017 Cell Line ES7 Homo sapiens IC50 = 177447.89 nM 19692149
NPT2077 Cell Line SCC-3 Homo sapiens IC50 = 2828.91 nM PubChem BioAssay data set
NPT2 Others Unspecified IC50 = 9.6 nM 16472241
NPT2 Others Unspecified EC50 > 10000 nM 20020916
NPT165 Cell Line HeLa Homo sapiens EC50 > 10000 nM PubChem BioAssay data set
NPT3120 Individual Protein Serine/threonine-protein kinase PAK 1 Homo sapiens Kd > 10000 nM DrugMatrix in vitro pharmacology data
NPT2121 Cell Line LB2241-RCC Homo sapiens IC50 = 238478.22 nM DrugMatrix in vitro pharmacology data
NPT3236 Individual Protein Death-associated protein kinase 2 Homo sapiens Kd = 470 nM DrugMatrix in vitro pharmacology data
NPT165 Cell Line HeLa Homo sapiens Activity = 1.051 DrugMatrix in vitro pharmacology data
NPT2245 Cell Line SiHa Homo sapiens Activity = 1.014 DrugMatrix in vitro pharmacology data
NPT165 Cell Line HeLa Homo sapiens Activity = 1.06 DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified Activity = 0.914 DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified Activity = 1.544 DrugMatrix in vitro pharmacology data
NPT393 Cell Line HCT-116 Homo sapiens Activity = 0.924 DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified Activity = 0.951 DrugMatrix in vitro pharmacology data
NPT180 Cell Line HCT-8 Homo sapiens Activity = 1.028 DrugMatrix in vitro pharmacology data
NPT369 Cell Line ACHN Homo sapiens IC50 = 2500 nM DrugMatrix in vitro pharmacology data
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 0.99 nM DrugMatrix in vitro pharmacology data
NPT2170 Cell Line RKO Homo sapiens IC50 = 44125.24 nM DrugMatrix in vitro pharmacology data
NPT3320 Individual Protein Proto-oncogene tyrosine-protein kinase MER Homo sapiens Kd = 26 nM PubChem BioAssay data set
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 147 nM PubChem BioAssay data set
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 98 nM PubChem BioAssay data set
NPT1480 Individual Protein Fibroblast growth factor receptor 1 Homo sapiens Kd = 520 nM PubChem BioAssay data set
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Ki = 2.9 nM PubChem BioAssay data set
NPT1901 Cell Line EM-2 Homo sapiens IC50 = 18567.24 nM 22705001
NPT2125 Cell Line NCI-H1522 Homo sapiens IC50 = 779702.16 nM PubChem BioAssay data set
NPT2115 Cell Line HCC2157 Homo sapiens IC50 = 314432.99 nM PubChem BioAssay data set
NPT3408 Individual Protein Mitogen-activated protein kinase kinase kinase 13 Homo sapiens Kd = 95 nM 221658
NPT397 Cell Line NCI-H460 Homo sapiens IC50 = 2700 nM 592323
NPT1608 Individual Protein Serine/threonine-protein kinase Chk1 Homo sapiens Kd = 300 nM 592323
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 18350 nM PubChem BioAssay data set
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens IC50 = 2000 nM PubChem BioAssay data set
NPT3111 Individual Protein Tyrosine-protein kinase Lyn Homo sapiens Kd = 540 nM PubChem BioAssay data set
NPT2156 Cell Line SU-DHL-1 Homo sapiens IC50 = 4801.74 nM 25554367
NPT2130 Cell Line TE-10 Homo sapiens IC50 = 2343.84 nM 22676269
NPT1613 Individual Protein Ribosomal protein S6 kinase alpha 5 Homo sapiens Kd = 1700 nM 20825224
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.41 nM 16441076
NPT1692 Individual Protein Mitogen-activated protein kinase 6 Homo sapiens Kd > 10000 nM 26317881
NPT3111 Individual Protein Tyrosine-protein kinase Lyn Homo sapiens Kd = 540 nM 25581396
NPT2574 Individual Protein Insulin receptor Homo sapiens Kd = 180 nM 25585025
NPT1689 Individual Protein Tyrosine-protein kinase JAK1 Homo sapiens Kd = 9 nM 25585025
NPT1439 Individual Protein Tyrosine-protein kinase ITK/TSK Homo sapiens Kd = 13 nM 25647077
NPT83 Cell Line MCF7 Homo sapiens IC50 = 6290 nM 19228000
NPT282 Individual Protein MAP kinase ERK2 Homo sapiens Kd > 10000 nM 17190440
NPT2572 Individual Protein Ephrin type-B receptor 4 Homo sapiens Kd = 2200 nM 9834160
NPT2128 Cell Line RCC10RGB Homo sapiens IC50 = 366741.78 nM 16643028
NPT3280 Individual Protein Serine/threonine-protein kinase c-TAK1 Homo sapiens Kd = 410 nM 16643028
NPT2120 Cell Line LB1047-RCC Homo sapiens IC50 = 1816.24 nM 11421741
NPT1996 Cell Line NB5 Homo sapiens IC50 = 80719.32 nM 11421732
NPT2 Others Unspecified Kd = 2.3 nM 24387703
NPT2 Others Unspecified Kd = 4.3 nM 24387703
NPT2490 Cell Line NCI-H1666 Homo sapiens Activity = 1.035 20061160
NPT2179 Cell Line LC-1F Homo sapiens IC50 = 43368.22 nM 18363378
NPT1970 Cell Line THP-1 Homo sapiens IC50 = 45.7 nM 18973388
NPT2182 Cell Line Mo Homo sapiens IC50 = 999979.72 nM 10543897
NPT3295 Individual Protein Activin receptor type-2B Homo sapiens Kd > 10000 nM 22858297
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens IC50 = 8.9 nM 21865046
NPT1687 Individual Protein Death-associated protein kinase 3 Homo sapiens Kd = 100 nM DrugMatrix in vitro pharmacology data
NPT397 Cell Line NCI-H460 Homo sapiens IC50 > 4000 nM DrugMatrix in vitro pharmacology data
NPT2099 Cell Line KE-37 Homo sapiens IC50 = 4061.58 nM DrugMatrix in vitro pharmacology data
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 9 nM DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified GI50 = 110 nM DrugMatrix in vitro pharmacology data
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens GI50 = 1380 nM DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified GI50 = 41 nM DrugMatrix in vitro pharmacology data
NPT464 Cell Line Daudi Homo sapiens IC50 = 8235.46 nM DrugMatrix in vitro pharmacology data
NPT2048 Cell Line HCC1187 Homo sapiens IC50 = 18018.75 nM DrugMatrix in vitro pharmacology data
NPT1424 Individual Protein Serine/threonine-protein kinase RAF Homo sapiens Kd > 10000 nM DrugMatrix in vitro pharmacology data
NPT1684 Individual Protein Casein kinase I gamma 1 Homo sapiens Kd = 930 nM 17609121
NPT1613 Individual Protein Ribosomal protein S6 kinase alpha 5 Homo sapiens Kd = 250 nM 22804108
NPT374 Cell Line SF-539 Homo sapiens IC50 = 106449.32 nM 22871217
NPT2189 Cell Line TE-9 Homo sapiens IC50 = 37040.1 nM 24547740
NPT308 Cell Line CAKI-1 Homo sapiens GI50 = 630 nM 12662090
NPT83 Cell Line MCF7 Homo sapiens GI50 = 2000 nM 12662090
NPT400 Cell Line MDA-MB-435 Homo sapiens GI50 = 2000 nM 12662090
NPT377 Cell Line OVCAR-3 Homo sapiens GI50 = 3200 nM 26105195
NPT831 Individual Protein Serine/threonine-protein kinase PLK1 Homo sapiens IC50 > 10000 nM 26105195
NPT323 Cell Line SW-620 Homo sapiens GI50 = 1300 nM 26105195
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 70 nM 26105195
NPT728 Individual Protein Serine/threonine-protein kinase AKT Homo sapiens IC50 > 10000 nM 26105195
NPT1433 Individual Protein Serine/threonine-protein kinase Aurora-B Homo sapiens IC50 = 1500 nM 26105195
NPT994 Cell Line ZR-75-30 Homo sapiens Activity = 1.095 26105195
NPT2 Others Unspecified Activity = 0.983 26105195
NPT2444 Cell Line YAPC Homo sapiens Activity = 0.801 26105195
NPT2457 Cell Line YKG-1 Homo sapiens Activity = 0.916 26105195
NPT133 Cell Line ZR-75-1 Homo sapiens Activity = 1.04 26105195
NPT2 Others Unspecified Activity = 1.045 26105195
NPT2 Others Unspecified Activity = 0.902 26105195
NPT2 Others Unspecified Activity = 1.027 20806907
NPT2 Others Unspecified Activity = 1.093 17723297
NPT1535 Cell Line U-87 MG Homo sapiens IC50 = 440400.7 nM 17685651
NPT2626 Individual Protein Myosin light chain kinase, smooth muscle Homo sapiens Kd = 23 nM 12027749
NPT3282 Individual Protein Maternal embryonic leucine zipper kinase Homo sapiens Kd = 350 nM 17850214
NPT3381 Individual Protein Misshapen-like kinase 1 Homo sapiens Kd = 29 nM 17850214
NPT1711 Individual Protein Serine/threonine-protein kinase MST1 Homo sapiens Kd = 19 nM 17850214
NPT3331 Individual Protein Serine/threonine-protein kinase MST2 Homo sapiens Kd = 56 nM 17850214
NPT2856 Individual Protein Sodium channel protein type V alpha subunit Homo sapiens IC50 = 39810.72 nM 15568791
NPT3231 Individual Protein Dual specificity protein kinase CLK4 Homo sapiens Kd = 29 nM 20738102
NPT1046 Individual Protein NAD-dependent deacetylase sirtuin 1 Homo sapiens Inhibition < 10 % 12646019
NPT1964 Cell Line COLO-684 Homo sapiens IC50 = 90456.22 nM 12646019
NPT3235 Individual Protein MAP/microtubule affinity-regulating kinase 2 Homo sapiens Kd = 310 nM 15711537
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 0.47 nM 17425296
NPT81 Cell Line A549 Homo sapiens IC50 = 6610 nM 18077425
NPT2132 Cell Line EOL1 Homo sapiens IC50 = 0.001635 nM 18077425
NPT2186 Cell Line RL Homo sapiens IC50 = 890094.82 nM 18077425
NPT2203 Cell Line GDM-1 Homo sapiens IC50 = 21941.42 nM 18077425
NPT3208 Individual Protein Serine/threonine-protein kinase 36 Homo sapiens Kd > 10000 nM 18077425
NPT2 Others Unspecified IC50 = 59750 nM 18077425
NPT3292 Individual Protein Serine/threonine-protein kinase SRPK2 Homo sapiens Kd = 190 nM 18077425
NPT3316 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens Kd = 140 nM 18183025
NPT3217 Individual Protein Ephrin type-A receptor 3 Homo sapiens Kd = 2100 nM 18183025
NPT3211 Individual Protein Ephrin type-A receptor 7 Homo sapiens Kd = 2400 nM 18183025
NPT3220 Individual Protein Ephrin type-A receptor 6 Homo sapiens Kd = 960 nM 18183025
NPT1680 Individual Protein Serine/threonine-protein kinase Chk2 Homo sapiens Kd = 10 nM 18183025
NPT286 Individual Protein Receptor protein-tyrosine kinase erbB-2 Homo sapiens Kd > 10000 nM 18183025
NPT2072 Cell Line MN-60 Homo sapiens IC50 = 7540.88 nM 18183025
NPT3265 Individual Protein Casein kinase I isoform alpha-like Homo sapiens Kd = 550 nM 18183025
NPT3328 Individual Protein Mitogen-activated protein kinase kinase kinase 11 Homo sapiens Kd = 1300 nM 18183025
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens IC50 < 1 nM 18183025
NPT2 Others Unspecified IC50 < 1 nM 18183025
NPT2574 Individual Protein Insulin receptor Homo sapiens IC50 = 3200 nM 18183025
NPT3464 Individual Protein Myelin transcription factor 1 Homo sapiens Activity < 5 % 18183025
NPT2003 Cell Line LS-1034 Homo sapiens IC50 = 154318.55 nM 19654408
NPT3219 Individual Protein Ephrin type-A receptor 5 Homo sapiens Kd > 10000 nM 19654408
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 3700 nM 19654408
NPT1919 Cell Line DOHH-2 Homo sapiens IC50 = 2334.31 nM 19654408
NPT887 Individual Protein Protein kinase C theta Homo sapiens Kd = 4300 nM 19654408
NPT1706 Individual Protein Serine/threonine-protein kinase 2 Homo sapiens Kd = 81 nM 19654408
NPT1424 Individual Protein Serine/threonine-protein kinase RAF Homo sapiens IC50 > 10000 nM 19654408
NPT3271 Individual Protein NT-3 growth factor receptor Homo sapiens Kd = 5100 nM 19654408
NPT1707 Individual Protein Serine/threonine-protein kinase 10 Homo sapiens Kd = 640 nM 19654408
NPT3314 Individual Protein Bone morphogenetic protein receptor type-2 Homo sapiens Kd = 570 nM 21450463
NPT3277 Individual Protein Tyrosine-protein kinase receptor TYRO3 Homo sapiens Kd = 49 nM 22037378
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 = 172100 nM 22037378
NPT3341 Individual Protein Serine/threonine-protein kinase Nek5 Homo sapiens Kd > 10000 nM 22037378
NPT3309 Individual Protein Leukocyte tyrosine kinase receptor Homo sapiens Kd = 1800 nM 22037378
NPT3302 Individual Protein Ankyrin repeat and protein kinase domain-containing protein 1 Homo sapiens Kd = 310 nM 22037378
NPT1613 Individual Protein Ribosomal protein S6 kinase alpha 5 Homo sapiens Kd = 28 nM 22037378
NPT3446 Individual Protein Myosin light chain kinase Homo sapiens Kd = 23 nM 22037378
NPT3249 Individual Protein Tyrosine- and threonine-specific cdc2-inhibitory kinase Homo sapiens Kd > 10000 nM 22037378
NPT3447 Individual Protein G protein-coupled receptor kinase 4 Homo sapiens Kd = 140 nM 22037378
NPT3448 Individual Protein Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens Kd = 110 nM 22037378
NPT3448 Individual Protein Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens Kd = 76 nM 22037378
NPT845 Cell Line BT-474 Homo sapiens Activity = 1.31 22037378
NPT2 Others Unspecified Activity = 1.138 22037378
NPT2 Others Unspecified Activity = 1.006 22037378
NPT2 Others Unspecified Activity = 0.892 22037378
NPT2320 Cell Line BFTC-909 Homo sapiens Activity = 1.131 22037378
NPT2321 Cell Line BHT-101 Homo sapiens Activity = 1.152 22037378
NPT2314 Cell Line BEN Homo sapiens Activity = 0.986 22037378
NPT2315 Cell Line BFTC-905 Homo sapiens Activity = 0.93 22037378
NPT457 Cell Line BT-549 Homo sapiens Activity = 1.154 22037378
NPT2 Others Unspecified Activity = 1.074 22037378
NPT1946 Cell Line D-263MG Homo sapiens IC50 = 200070.54 nM 22037378
NPT2042 Cell Line SBC-1 Homo sapiens IC50 = 738121.17 nM 22037378
NPT3320 Individual Protein Proto-oncogene tyrosine-protein kinase MER Homo sapiens Activity = 99.6 % 22037378
NPT3221 Individual Protein Serine/threonine-protein kinase GAK Homo sapiens Kd = 20 nM 22037378
NPT1681 Individual Protein Dual specificty protein kinase CLK1 Homo sapiens Kd = 100 nM 22194678
NPT3352 Individual Protein Dual specificity testis-specific protein kinase 1 Homo sapiens Kd > 10000 nM 10.1007/s00044-012-0170-3
NPT933 Cell Line U373 MG Homo sapiens Activity = 1.055 10.6019/CHEMBL1201861
NPT2194 Cell Line IMR-5 Homo sapiens IC50 = 7548.76 nM 10.6019/CHEMBL1201861
NPT1431 Individual Protein Mitogen-activated protein kinase kinase kinase 5 Homo sapiens Kd > 10000 nM 10.6019/CHEMBL1201861
NPT3213 Individual Protein MAP kinase signal-integrating kinase 2 Homo sapiens Kd > 10000 nM 10.6019/CHEMBL1201861
NPT1966 Cell Line NCI-H1838 Homo sapiens IC50 = 101554.95 nM 10.6019/CHEMBL1201861
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Inhibition = 82.1 % 10.6019/CHEMBL1201861
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Inhibition = 89.7 % 10.6019/CHEMBL1201861
NPT3232 Individual Protein CaM kinase I alpha Homo sapiens Kd = 970 nM 10.6019/CHEMBL1201861
NPT2 Others Unspecified GI50 = 2010 nM 10.6019/CHEMBL1201861
NPT111 Cell Line K562 Homo sapiens GI50 = 1000 nM 10.6019/CHEMBL1201861
NPT3246 Individual Protein Tyrosine-protein kinase JAK2 Homo sapiens Kd = 410 nM 10.6019/CHEMBL1201861
NPT2 Others Unspecified Activity = 0.984 23768909
NPT982 Individual Protein Inhibitor of nuclear factor kappa B kinase alpha subunit Homo sapiens Kd = 520 nM 23999040
NPT2455 Cell Line SNU-C2B Homo sapiens IC50 = 149036.76 nM 10.1039/C1MD00105A
NPT1706 Individual Protein Serine/threonine-protein kinase 2 Homo sapiens Kd = 56 nM 25087753
NPT5891 Individual Protein Voltage-gated potassium channel subunit Kv4.3 Homo sapiens IC50 = 50118.72 nM 26009164
NPT3296 Individual Protein Serine/threonine-protein kinase 33 Homo sapiens Kd = 17 nM Patent: EP2818471 A1
NPT2856 Individual Protein Sodium channel protein type V alpha subunit Homo sapiens IC50 = 15848.93 nM 10.1039/C6MD00170J
NPT1938 Cell Line Calu-6 Homo sapiens IC50 = 322909.47 nM PubChem BioAssay data set
NPT65 Cell Line HepG2 Homo sapiens IC50 = 16060 nM PubChem BioAssay data set
NPT3276 Individual Protein Tyrosine-protein kinase TYK2 Homo sapiens Kd = 1600 nM PubChem BioAssay data set
NPT3370 Individual Protein Tyrosine-protein kinase receptor RET Homo sapiens IC50 = 224 nM 20384296
NPT1681 Individual Protein Dual specificty protein kinase CLK1 Homo sapiens Kd = 22 nM 19271765
NPT98 Individual Protein HERG Homo sapiens IC50 = 500 nM 26034885
NPT2021 Cell Line LS-411N Homo sapiens IC50 = 377461.28 nM 26034885
NPT1426 Individual Protein c-Jun N-terminal kinase 1 Homo sapiens Kd > 10000 nM 15217270
NPT2200 Cell Line RPMI-6666 Homo sapiens IC50 = 3541.71 nM 18841906
NPT3106 Individual Protein Ribosomal protein S6 kinase alpha 1 Homo sapiens Kd = 5000 nM 24033101
NPT165 Cell Line HeLa Homo sapiens IC50 > 30000 nM 3210015
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens IC50 = 550 nM 7807120
NPT1689 Individual Protein Tyrosine-protein kinase JAK1 Homo sapiens Kd = 9.2 nM 8759172
NPT2 Others Unspecified Activity = 0.933 20553004
NPT2 Others Unspecified Activity = 0.793 20553004
NPT3123 Cell Line DAN-G Homo sapiens Activity = 1.036 20553004
NPT2 Others Unspecified Activity = 0.955 24582402
NPT2 Others Unspecified Activity = 0.898 24582402
NPT592 Individual Protein Rho-associated protein kinase 1 Homo sapiens Kd = 460 nM 24164206
NPT3371 Individual Protein Receptor-interacting serine/threonine-protein kinase 1 Homo sapiens Kd = 370 nM 24164206
NPT3374 Individual Protein Ribosomal protein S6 kinase alpha 4 Homo sapiens Kd = 140 nM 24164206
NPT3106 Individual Protein Ribosomal protein S6 kinase alpha 1 Homo sapiens Kd = 580 nM 24164206
NPT1613 Individual Protein Ribosomal protein S6 kinase alpha 5 Homo sapiens Kd = 17 nM 24164206
NPT3234 Individual Protein Ribosomal protein S6 kinase alpha 2 Homo sapiens Kd = 28 nM 24164206
NPT3106 Individual Protein Ribosomal protein S6 kinase alpha 1 Homo sapiens Kd = 96 nM 24164206
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens IC50 = 1613 nM 17158054
NPT676 Individual Protein Glycogen synthase kinase-3 alpha Homo sapiens Kd > 10000 nM 1919590
NPT281 Individual Protein MAP kinase ERK1 Homo sapiens Kd > 10000 nM 25798528
NPT2572 Individual Protein Ephrin type-B receptor 4 Homo sapiens Kd > 10000 nM 23268606
NPT3401 Individual Protein Cyclin-dependent kinase 13 Homo sapiens Kd > 10000 nM 22148349
NPT3400 Individual Protein Peripheral plasma membrane protein CASK Homo sapiens Kd > 10000 nM 22148349
NPT1612 Individual Protein MAP kinase-activated protein kinase 5 Homo sapiens Kd > 10000 nM 3210015
NPT3232 Individual Protein CaM kinase I alpha Homo sapiens Kd = 970 nM 3210015
NPT3402 Individual Protein Serine/threonine-protein kinase PRP4 homolog Homo sapiens Kd = 390 nM 1431944
NPT3289 Individual Protein Serine/threonine-protein kinase RIO3 Homo sapiens Kd = 3800 nM 1431944
NPT1447 Individual Protein Serine/threonine-protein kinase RIPK2 Homo sapiens Kd > 10000 nM 23540981
NPT3403 Individual Protein Cyclin-dependent kinase-like 2 Homo sapiens Kd = 1100 nM 19007285
NPT1663 Individual Protein Tyrosine-protein kinase YES Homo sapiens Potency 48.7 nM 15730264
NPT1663 Individual Protein Tyrosine-protein kinase YES Homo sapiens Kd = 240 nM 7506311
NPT737 Cell Line HUVEC Homo sapiens IC50 = 4040 nM 22642560
NPT3253 Individual Protein Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha Homo sapiens Kd = 5400 nM 22703109
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 8 nM 12502331
NPT3333 Individual Protein Muscle, skeletal receptor tyrosine protein kinase Homo sapiens Kd = 490 nM 24660966
NPT2 Others Unspecified Activity = 1.048 10450990
NPT3233 Individual Protein Serine/threonine-protein kinase 38-like Homo sapiens Kd = 970 nM 8176705
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 0.8 nM 16472241
NPT2316 Cell Line CFPAC-1 Homo sapiens Activity = 0.868 DrugMatrix in vitro pharmacology data
NPT3209 Individual Protein Mitogen-activated protein kinase kinase kinase 4 Homo sapiens Kd = 3300 nM DrugMatrix in vitro pharmacology data
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens IC50 = 83100 nM DrugMatrix in vitro pharmacology data
NPT3113 Individual Protein Tyrosine-protein kinase CSK Homo sapiens Kd > 10000 nM DrugMatrix in vitro pharmacology data
NPT2145 Cell Line TE-15 Homo sapiens IC50 = 507.61 nM DrugMatrix in vitro pharmacology data
NPT2029 Cell Line SW 954 Homo sapiens IC50 = 6275.17 nM PubChem BioAssay data set
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens IC50 = 3 nM 26469743
NPT3397 Individual Protein Cyclin-dependent kinase-like 5 Homo sapiens Kd > 10000 nM 16792405
NPT1683 Individual Protein Dual specificity protein kinase CLK3 Homo sapiens Kd > 10000 nM 20121237
NPT3347 Individual Protein Cyclin-dependent kinase 9 Homo sapiens Kd > 10000 nM 20121237
NPT3384 Individual Protein Cyclin-dependent kinase-like 3 Homo sapiens Kd > 10000 nM 20121237
NPT3240 Individual Protein Cyclin-dependent kinase 5 Homo sapiens Kd > 10000 nM 20121237
NPT3324 Individual Protein Cell division protein kinase 8 Homo sapiens Kd > 10000 nM 20121237
NPT1371 Individual Protein Cyclin-dependent kinase 2 Homo sapiens Kd > 10000 nM 20121237
NPT3345 Individual Protein Cyclin-dependent kinase 3 Homo sapiens Kd > 10000 nM 15104487
NPT3322 Individual Protein PITSLRE serine/threonine-protein kinase CDC2L2 Homo sapiens Kd > 10000 nM 15104487
NPT3323 Individual Protein Cell division cycle 2-like protein kinase 6 Homo sapiens Kd > 10000 nM 15104487
NPT3337 Individual Protein Serine/threonine-protein kinase DCLK3 Homo sapiens Kd = 110 nM 24613627
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 1000 nM 11266159
NPT3359 Individual Protein Ephrin type-B receptor 3 Homo sapiens Kd > 10000 nM 17850214
NPT1038 Individual Protein Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 70794.6 nM PubChem BioAssay data set
NPT2427 Cell Line HCC1954 Homo sapiens Activity = 1.218 PubChem BioAssay data set
NPT389 Cell Line RPMI-8226 Homo sapiens IC50 = 7507.39 nM 24613627
NPT2159 Cell Line TE-5 Homo sapiens IC50 = 177295.71 nM 1335082
NPT2357 Cell Line RT-112 Homo sapiens Activity = 0.681 8388467
NPT2 Others Unspecified Activity = 0.779 8388467
NPT4608 Cell Line RT-4 Homo sapiens Activity = 1.033 3820216
NPT2370 Cell Line RVH-421 Homo sapiens Activity = 1.059 3820216
NPT2 Others Unspecified Activity = 0.903 3820216
NPT2 Others Unspecified Activity = 1.013 3820216
NPT1091 Cell Line RPMI-7951 Homo sapiens Activity = 0.81 3820216
NPT2392 Cell Line S-117 Homo sapiens Activity = 1.043 2374153
NPT2405 Cell Line SAOS-2 Homo sapiens Activity = 0.945 2374153
NPT2043 Cell Line SK-NEP-1 Homo sapiens IC50 = 2602.37 nM 17261620
NPT112 Cell Line MOLT-4 Homo sapiens IC50 = 3398.38 nM 18718695
NPT1948 Cell Line A253 cell line IC50 = 275450.52 nM 18524419
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Kd = 950 nM 18676884
NPT1447 Individual Protein Serine/threonine-protein kinase RIPK2 Homo sapiens Kd > 10000 nM 20498323
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Ki = 9 nM 18426901
NPT3267 Individual Protein Macrophage colony stimulating factor receptor Homo sapiens Activity = 2 % 19786608
NPT3222 Individual Protein AMP-activated protein kinase, alpha-1 subunit Homo sapiens Kd = 52 nM 20713679
NPT1934 Cell Line BB49-HNC Homo sapiens IC50 = 3705.08 nM 16472241
NPT3395 Individual Protein Rhodopsin kinase Homo sapiens Kd = 290 nM DrugMatrix in vitro pharmacology data
NPT14 Individual Protein Tyrosine-protein kinase FYN Homo sapiens Kd = 520 nM DrugMatrix in vitro pharmacology data
NPT3204 Individual Protein Tyrosine-protein kinase FRK Homo sapiens Kd = 530 nM DrugMatrix in vitro pharmacology data
NPT3221 Individual Protein Serine/threonine-protein kinase GAK Homo sapiens Kd = 20 nM DrugMatrix in vitro pharmacology data
NPT3438 Individual Protein G protein-coupled receptor kinase 7 Homo sapiens Kd = 180 nM DrugMatrix in vitro pharmacology data
NPT3447 Individual Protein G protein-coupled receptor kinase 4 Homo sapiens Kd = 140 nM DrugMatrix in vitro pharmacology data
NPT1183 Cell Line WiDr Homo sapiens Activity = 1.095 DrugMatrix in vitro pharmacology data
NPT1475 Cell Line WI-38 VA13 Homo sapiens Activity = 0.935 DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified Activity = 0.804 DrugMatrix in vitro pharmacology data
NPT2514 Cell Line LN-405 Homo sapiens Activity = 0.844 DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified Activity = 0.916 DrugMatrix in vitro pharmacology data
NPT2436 Cell Line VMRC-RCZ Homo sapiens Activity = 0.772 DrugMatrix in vitro pharmacology data
NPT2513 Cell Line LK-2 Homo sapiens Activity = 1 DrugMatrix in vitro pharmacology data
NPT2512 Cell Line LCLC-97TM1 Homo sapiens Activity = 1.265 DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified Activity = 0.985 DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified Activity = 1.228 DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified IC50 = 12000 nM DrugMatrix in vitro pharmacology data
NPT2085 Cell Line Kasumi 1 IC50 = 16 nM DrugMatrix in vitro pharmacology data
NPT3246 Individual Protein Tyrosine-protein kinase JAK2 Homo sapiens Kd = 410 nM 22194678
NPT3368 Individual Protein cGMP-dependent protein kinase 2 Homo sapiens Kd > 10000 nM 22194678
NPT3405 Individual Protein Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma Homo sapiens Kd > 10000 nM 10.1007/s00044-012-0143-6
NPT3404 Individual Protein Ephrin type-B receptor 6 Homo sapiens Kd = 1000 nM 10.1007/s00044-012-0143-6
NPT2572 Individual Protein Ephrin type-B receptor 4 Homo sapiens Kd = 3100 nM 10.1007/s00044-012-0143-6
NPT3359 Individual Protein Ephrin type-B receptor 3 Homo sapiens Kd > 10000 nM 10.1007/s00044-012-0101-3
NPT3212 Individual Protein Ephrin type-B receptor 1 Homo sapiens Kd = 480 nM 10.1007/s00044-013-0521-8
NPT3211 Individual Protein Ephrin type-A receptor 7 Homo sapiens Kd = 2400 nM 10.1007/s00044-013-0521-8
NPT3218 Individual Protein Ephrin type-A receptor 4 Homo sapiens Kd > 10000 nM 10.1007/s00044-013-0521-8
NPT3225 Individual Protein Ephrin type-A receptor 2 Homo sapiens Kd > 10000 nM 10.1007/s00044-013-0521-8
NPT1688 Individual Protein Myotonin-protein kinase Homo sapiens Kd > 10000 nM 10.1007/s00044-013-0521-8
NPT1686 Individual Protein Casein kinase I isoform gamma-3 Homo sapiens Kd = 240 nM 10.1007/s00044-013-0521-8
NPT2193 Cell Line IM-9 Homo sapiens IC50 = 1350 nM 10.1007/s00044-012-0253-1
NPT2068 Cell Line L-363 Homo sapiens IC50 = 4806.21 nM DrugMatrix in vivo data: Pathology
NPT3224 Individual Protein Phosphorylase kinase gamma subunit 1 Homo sapiens Kd = 70 nM DrugMatrix in vivo data: Pathology
NPT3275 Individual Protein Inhibitor of nuclear factor kappa B kinase epsilon subunit Homo sapiens Kd = 620 nM DrugMatrix in vivo data: Pathology
NPT1979 Cell Line NB13 Homo sapiens IC50 = 9799.94 nM DrugMatrix in vivo data: Pathology
NPT1699 Individual Protein 3-phosphoinositide dependent protein kinase-1 Homo sapiens Kd = 3500 nM DrugMatrix in vivo data: Biochemistry
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Inhibition = 78.8 % DrugMatrix in vivo data: Biochemistry
NPT6530 Cell Line MOLM-13 Homo sapiens IC50 = 17.7 nM 24128814
NPT3363 Individual Protein Mitogen-activated protein kinase 15 Homo sapiens Kd > 10000 nM 15646539
NPT1430 Individual Protein Serine/threonine-protein kinase AKT2 Homo sapiens Kd = 2700 nM 15646539
NPT1950 Cell Line BL-70 Homo sapiens IC50 = 1118.46 nM 26034885
NPT1921 Cell Line COR-L279 Homo sapiens IC50 = 9390.9 nM 26034885
NPT2 Others Unspecified Kd = 130 nM 27338658
NPT2575 Individual Protein Platelet-derived growth factor receptor beta Homo sapiens Kd = 0.2 nM 27338658
NPT1480 Individual Protein Fibroblast growth factor receptor 1 Homo sapiens IC50 = 170 nM DailyMed
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens IC50 = 27 nM DailyMed
NPT3206 Individual Protein Serine/threonine-protein kinase Aurora-C Homo sapiens Kd = 310 nM DailyMed
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Kd = 0.2 nM DailyMed
NPT3221 Individual Protein Serine/threonine-protein kinase GAK Homo sapiens Kd = 120 nM DailyMed
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens Kd = 0.8 nM DailyMed
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.7 nM DailyMed
NPT3324 Individual Protein Cell division protein kinase 8 Homo sapiens Kd > 10000 nM 20189404
NPT2 Others Unspecified IC50 = 33400 nM 20045651
NPT1927 Cell Line ARH-77 Homo sapiens IC50 = 7535.97 nM 22705001
NPT2574 Individual Protein Insulin receptor Homo sapiens Kd = 500 nM 22705001
NPT1440 Individual Protein Tyrosine-protein kinase JAK3 Homo sapiens Kd = 1200 nM 22705001
NPT3227 Individual Protein Fibroblast growth factor receptor 3 Homo sapiens Kd = 290 nM 22705001
NPT3227 Individual Protein Fibroblast growth factor receptor 3 Homo sapiens Kd = 1400 nM 22705001
NPT2213 Individual Protein Cyclin-dependent kinase 4 Homo sapiens Kd = 6200 nM 22705001
NPT2213 Individual Protein Cyclin-dependent kinase 4 Homo sapiens Kd = 2000 nM 22705001
NPT3304 Individual Protein Serine/threonine-protein kinase receptor R3 Homo sapiens Kd > 10000 nM 22583079
NPT833 Individual Protein Tyrosine-protein kinase BTK Homo sapiens Kd = 2100 nM 22583079
NPT3250 Individual Protein Serine/threonine-protein kinase PCTAIRE-2 Homo sapiens Kd = 1200 nM 22583079
NPT2750 Individual Protein Tyrosine-protein kinase BMX Homo sapiens Kd > 10000 nM 11858752
NPT390 Cell Line LOX IMVI Homo sapiens IC50 = 16255.98 nM 11421741
NPT2062 Cell Line SCC-15 Homo sapiens IC50 = 127049.15 nM 21970540
NPT1915 Cell Line COLO-829 Homo sapiens IC50 = 359086.75 nM 21982797
NPT3109 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens Kd = 77 nM 21982797
NPT1701 Individual Protein Serine/threonine-protein kinase PIM3 Homo sapiens Kd = 2400 nM 17253840
NPT2 Others Unspecified IC50 = 75600 nM 19285413
NPT737 Cell Line HUVEC Homo sapiens IC50 = 2750 nM 8289059
NPT2573 Individual Protein Vascular endothelial growth factor receptor 3 Homo sapiens Kd = 35 nM 8289059
NPT1945 Cell Line CHP-126 Homo sapiens IC50 = 591933.32 nM 8289059
NPT1481 Individual Protein Fibroblast growth factor receptor 2 Homo sapiens Kd = 530 nM 8289059
NPT3212 Individual Protein Ephrin type-B receptor 1 Homo sapiens Kd = 960 nM 8289059
NPT4607 Cell Line TT Homo sapiens IC50 = 40 nM 8289060
NPT2573 Individual Protein Vascular endothelial growth factor receptor 3 Homo sapiens Ki = 17 nM 8289060
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Ki = 9 nM 20384315
NPT1912 Cell Line COLO-800 Homo sapiens IC50 = 606515.33 nM 15104496
NPT301 Individual Protein Vascular endothelial growth factor receptor 1 Homo sapiens Kd = 1.8 nM 25127165
NPT3350 Individual Protein Tyrosine-protein kinase Srms Homo sapiens Kd > 10000 nM 20579892
NPT2096 Cell Line VA-ES-BJ Homo sapiens IC50 = 9999.33 nM 10869199
NPT1936 Cell Line BC-3 Homo sapiens IC50 = 12465.08 nM 10.1584/jpestics.16.93
NPT1649 Cell Line MV4-11 Homo sapiens IC50 = 4.3 nM 19115838
NPT1650 Individual Protein Tyrosine-protein kinase receptor FLT3 Homo sapiens IC50 = 9.9 nM 19115838
NPT1661 Individual Protein ALK tyrosine kinase receptor Homo sapiens Kd = 170 nM 17665951
NPT3222 Individual Protein AMP-activated protein kinase, alpha-1 subunit Homo sapiens Kd = 19 nM 17665951
NPT2 Others Unspecified Kd = 140 nM 17665951
NPT2 Others Unspecified Kd = 950 nM 17665951
NPT2 Others Unspecified Kd = 890 nM 17665951
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens Kd > 10000 nM 17665951
NPT1689 Individual Protein Tyrosine-protein kinase JAK1 Homo sapiens Kd = 6000 nM 17665951
NPT2 Others Unspecified Activity = 0.94 24195447
NPT1678 Individual Protein CaM-kinase kinase beta Homo sapiens Kd = 1500 nM 24224843
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Kd = 1.5 nM 11170665
NPT199 Individual Protein DNA polymerase kappa Homo sapiens Potency 13371.4 nM 21130542
NPT2729 Individual Protein Tyrosine-protein kinase ABL Homo sapiens Activity = 100 % 10924166
NPT32 Organism Mus musculus Mus musculus Inhibition = 0 % 17497807
NPT2104 Cell Line NCI-H1417 Homo sapiens IC50 = 1837567.56 nM 23734701
NPT1892 Cell Line H4 Rattus norvegicus Activity = 0.842 16499318
NPT2503 Cell Line NCI-H1703 Homo sapiens Activity = 0.365 9748375
NPT1179 Cell Line MKN-28 Homo sapiens Activity = 1.097 20550123
NPT2 Others Unspecified Activity = 1.107 20550123
NPT2 Others Unspecified Activity = 1.003 16989528
NPT2502 Cell Line MEL-JUSO Homo sapiens Activity = 0.945 16989528
NPT2489 Cell Line MeWo Homo sapiens Activity = 1.109 16989528
NPT2 Others Unspecified Activity = 1.024 11087596
NPT3882 Cell Line MFE-296 Homo sapiens Activity = 0.844 20738102
NPT2515 Cell Line MFE-280 Homo sapiens Activity = 1.184 20738102
NPT783 Cell Line MIA PaCa-2 Homo sapiens Activity = 0.991 20738102
NPT2351 Cell Line MG-63 Homo sapiens Activity = 0.92 20738102
NPT1981 Cell Line NCI-H1882 Homo sapiens IC50 = 17983.42 nM 15943472
NPT3312 Individual Protein Tyrosine-protein kinase BLK Homo sapiens Kd = 65 nM 17296744
NPT3314 Individual Protein Bone morphogenetic protein receptor type-2 Homo sapiens Kd = 570 nM 17296744
NPT1676 Individual Protein CaM kinase II gamma Homo sapiens Kd = 440 nM 17296744
NPT1672 Individual Protein CaM kinase I delta Homo sapiens Kd = 510 nM 17296744
NPT2171 Cell Line SIG-M5 Homo sapiens IC50 = 1370.09 nM 19419201
NPT1371 Individual Protein Cyclin-dependent kinase 2 Homo sapiens Kd > 10000 nM 18955520
NPT1995 Cell Line NB17 Homo sapiens IC50 = 60544.58 nM 18955520
NPT3346 Individual Protein Cyclin-dependent kinase 7 Homo sapiens Kd = 330 nM 19015327
NPT2002 Cell Line KY821 Homo sapiens IC50 = 2797.58 nM 19349520
NPT1710 Individual Protein Serine/threonine-protein kinase 38 Homo sapiens Kd = 410 nM 19651908
NPT3288 Individual Protein Interleukin-1 receptor-associated kinase 3 Homo sapiens Kd = 940 nM 19651908
NPT3109 Individual Protein Mitogen-activated protein kinase kinase kinase kinase 5 Homo sapiens Kd = 41 nM 19651908
NPT1678 Individual Protein CaM-kinase kinase beta Homo sapiens Kd = 1500 nM 19651908
NPT1717 Individual Protein Serine/threonine-protein kinase 25 Homo sapiens Kd = 290 nM 19651908
NPT3412 Individual Protein Mitogen-activated protein kinase kinase kinase 12 Homo sapiens Kd = 100 nM 19651908
NPT3334 Individual Protein Citron Rho-interacting kinase Homo sapiens Kd = 3900 nM 19651908
NPT1700 Individual Protein Serine/threonine-protein kinase PIM2 Homo sapiens Kd > 10000 nM 19651908
NPT3414 Individual Protein Serine/threonine-protein kinase PLK2 Homo sapiens Kd = 4700 nM 19651908
NPT3413 Individual Protein Mitogen-activated protein kinase kinase kinase 2 Homo sapiens Kd = 57 nM 19651908
NPT2016 Cell Line ES6 Homo sapiens IC50 = 981.06 nM 21565516
NPT1189 Cell Line DG-75 Homo sapiens IC50 = 6430.69 nM 23811085
NPT3291 Individual Protein Serine/threonine-protein kinase SRPK1 Homo sapiens Kd = 250 nM 24313801
NPT1478 Individual Protein Vascular endothelial growth factor receptor 2 Homo sapiens Ratio IC50 = 20 22584254
NPT3239 Individual Protein Nerve growth factor receptor Trk-A Homo sapiens Kd = 100 nM 20599387
NPT3268 Individual Protein Serine/threonine-protein kinase tousled-like 1 Homo sapiens Kd = 740 nM 20599387
NPT3269 Individual Protein Serine/threonine-protein kinase tousled-like 2 Homo sapiens Kd = 330 nM 20599387
NPT3297 Individual Protein Non-receptor tyrosine-protein kinase TNK1 Homo sapiens Kd = 680 nM 20599387
NPT1712 Individual Protein TRAF2- and NCK-interacting kinase Homo sapiens Kd = 25 nM 20599387
NPT1900 Cell Line DU-4475 Homo sapiens IC50 = 4367.29 nM PubChem BioAssay data set
NPT3367 Individual Protein cGMP-dependent protein kinase 1 beta Homo sapiens Kd > 10000 nM 9917313
NPT1705 Individual Protein Ribosomal protein S6 kinase alpha 3 Homo sapiens Kd = 580 nM 9917313
NPT1658 Individual Protein Serine/threonine-protein kinase NEK2 Homo sapiens Kd = 1400 nM 15165138
NPT737 Cell Line HUVEC Homo sapiens EC50 = 645 nM 15165138
NPT3210 Individual Protein BMP-2-inducible protein kinase Homo sapiens Kd = 5.5 nM 25368960
NPT845 Cell Line BT-474 Homo sapiens IC50 = 653346.75 nM 18077363
NPT3309 Individual Protein Leukocyte tyrosine kinase receptor Homo sapiens Kd = 1800 nM 18077363
NPT1440 Individual Protein Tyrosine-protein kinase JAK3 Homo sapiens Kd = 1200 nM 18077363
NPT1438 Individual Protein Insulin-like growth factor I receptor Homo sapiens Kd = 2600 nM 18077363
NPT2 Others Unspecified IC50 = 15500 nM 18077363
NPT1674 Individual Protein CaM kinase II alpha Homo sapiens Kd = 80 nM 18077363
NPT111 Cell Line K562 Homo sapiens IC50 = 21900 nM 1791472
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens Kd = 4700 nM 1791472
NPT3238 Individual Protein Dual specificity protein kinase TTK Homo sapiens Kd = 230 nM 1791472
NPT1433 Individual Protein Serine/threonine-protein kinase Aurora-B Homo sapiens Kd = 380 nM 21458113
NPT1197 Individual Protein Huntingtin Homo sapiens Potency = 35481.3 nM 15043435
NPT2576 Individual Protein Tyrosine-protein kinase TIE-2 Homo sapiens Kd > 10000 nM 23910596
NPT3258 Individual Protein Mixed lineage kinase 7 Homo sapiens Kd > 10000 nM 22916954
NPT1906 Cell Line EB-3 Homo sapiens IC50 = 29530.89 nM 20158243
NPT3246 Individual Protein Tyrosine-protein kinase JAK2 Homo sapiens Kd = 940 nM 15974609
NPT1701 Individual Protein Serine/threonine-protein kinase PIM3 Homo sapiens Kd = 2400 nM 11754602
NPT3379 Individual Protein Mitogen-activated protein kinase kinase kinase 15 Homo sapiens Kd = 1300 nM 11754602
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens Kd = 7200 nM 11754602
NPT1479 Individual Protein Stem cell growth factor receptor Homo sapiens Kd = 0.21 nM 11754602
NPT1337 Individual Protein Hepatocyte growth factor receptor Homo sapiens Kd = 1200 nM 11754602
NPT3279 Individual Protein Serine/threonine-protein kinase 11 Homo sapiens Kd = 38 nM 11754602
NPT1438 Individual Protein Insulin-like growth factor I receptor Homo sapiens Kd = 2600 nM 11754602
NPT2576 Individual Protein Tyrosine-protein kinase TIE-2 Homo sapiens Kd > 10000 nM 11754602
NPT139 Cell Line HT-29 Homo sapiens IC50 = 1700 nM 17190442
NPT3300 Individual Protein Serine/threonine-protein kinase 32B Homo sapiens Kd > 10000 nM 18302334
NPT3449 Individual Protein Wee1-like protein kinase 2 Homo sapiens Kd > 10000 nM 26287548
NPT3272 Individual Protein Tyrosine-protein kinase TXK Homo sapiens Kd > 10000 nM 26287548
NPT3298 Individual Protein Serine/threonine-protein kinase TNNI3K Homo sapiens Kd > 10000 nM 26287548
NPT3356 Individual Protein Tyrosine-protein kinase receptor Tie-1 Homo sapiens Kd > 10000 nM 26287548
NPT3355 Individual Protein TGF-beta receptor type II Homo sapiens Kd > 10000 nM 26287548
NPT3353 Individual Protein TGF-beta receptor type I Homo sapiens Kd > 10000 nM 26287401
NPT2126 Cell Line NKM-1 Homo sapiens IC50 = 98.52 nM 26287401

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC476118 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.8385 Intermediate Similarity NPC131718
0.8199 Intermediate Similarity NPC141353
0.8171 Intermediate Similarity NPC102423
0.814 Intermediate Similarity NPC472294
0.8095 Intermediate Similarity NPC313791
0.8024 Intermediate Similarity NPC317430
0.8 Intermediate Similarity NPC37548
0.7963 Intermediate Similarity NPC469765
0.7963 Intermediate Similarity NPC259644
0.7963 Intermediate Similarity NPC469763
0.7963 Intermediate Similarity NPC25008
0.7963 Intermediate Similarity NPC469786
0.7963 Intermediate Similarity NPC469760
0.7963 Intermediate Similarity NPC73952
0.7914 Intermediate Similarity NPC80597
0.7914 Intermediate Similarity NPC70922
0.7914 Intermediate Similarity NPC212376
0.7914 Intermediate Similarity NPC75540
0.7914 Intermediate Similarity NPC211572
0.7882 Intermediate Similarity NPC34508
0.7866 Intermediate Similarity NPC285469
0.7862 Intermediate Similarity NPC242556
0.7844 Intermediate Similarity NPC311276
0.784 Intermediate Similarity NPC24678
0.784 Intermediate Similarity NPC105818
0.7818 Intermediate Similarity NPC469762
0.7805 Intermediate Similarity NPC470507
0.7805 Intermediate Similarity NPC38736
0.7778 Intermediate Similarity NPC472123
0.7778 Intermediate Similarity NPC187951
0.7771 Intermediate Similarity NPC48938
0.7758 Intermediate Similarity NPC469785
0.7751 Intermediate Similarity NPC160105
0.774 Intermediate Similarity NPC171171
0.7717 Intermediate Similarity NPC249040
0.7714 Intermediate Similarity NPC314394
0.7702 Intermediate Similarity NPC159856
0.7702 Intermediate Similarity NPC314372
0.7701 Intermediate Similarity NPC270009
0.7701 Intermediate Similarity NPC72980
0.7692 Intermediate Similarity NPC198988
0.7684 Intermediate Similarity NPC314002
0.7679 Intermediate Similarity NPC16667
0.7674 Intermediate Similarity NPC314603
0.7669 Intermediate Similarity NPC124005
0.7665 Intermediate Similarity NPC230869
0.7647 Intermediate Similarity NPC49217
0.7647 Intermediate Similarity NPC474561
0.7647 Intermediate Similarity NPC49954
0.7644 Intermediate Similarity NPC293472
0.7637 Intermediate Similarity NPC195314
0.7627 Intermediate Similarity NPC204717
0.7616 Intermediate Similarity NPC158129
0.7614 Intermediate Similarity NPC192270
0.7605 Intermediate Similarity NPC299594
0.76 Intermediate Similarity NPC472443
0.7598 Intermediate Similarity NPC46580
0.7593 Intermediate Similarity NPC470440
0.759 Intermediate Similarity NPC207726
0.759 Intermediate Similarity NPC471458
0.7586 Intermediate Similarity NPC288785
0.7584 Intermediate Similarity NPC15102
0.7584 Intermediate Similarity NPC476319
0.7578 Intermediate Similarity NPC190296
0.7574 Intermediate Similarity NPC282231
0.7572 Intermediate Similarity NPC474409
0.7571 Intermediate Similarity NPC220765
0.7571 Intermediate Similarity NPC472108
0.7571 Intermediate Similarity NPC139291
0.7561 Intermediate Similarity NPC288445
0.756 Intermediate Similarity NPC135141
0.756 Intermediate Similarity NPC92796
0.7554 Intermediate Similarity NPC77555
0.7532 Intermediate Similarity NPC218268
0.7532 Intermediate Similarity NPC325252
0.7529 Intermediate Similarity NPC329688
0.7529 Intermediate Similarity NPC40779
0.7529 Intermediate Similarity NPC189812
0.7527 Intermediate Similarity NPC99666
0.7515 Intermediate Similarity NPC279918
0.75 Intermediate Similarity NPC88097
0.75 Intermediate Similarity NPC63751
0.75 Intermediate Similarity NPC212742
0.7486 Intermediate Similarity NPC163421
0.7486 Intermediate Similarity NPC188387
0.7472 Intermediate Similarity NPC472444
0.7472 Intermediate Similarity NPC19679
0.7459 Intermediate Similarity NPC213629
0.7459 Intermediate Similarity NPC46413
0.7458 Intermediate Similarity NPC91179
0.7457 Intermediate Similarity NPC280548
0.7456 Intermediate Similarity NPC67056
0.7453 Intermediate Similarity NPC2949
0.7453 Intermediate Similarity NPC59084
0.7452 Intermediate Similarity NPC184437
0.7444 Intermediate Similarity NPC94752
0.7443 Intermediate Similarity NPC184964
0.7443 Intermediate Similarity NPC59269
0.744 Intermediate Similarity NPC184476
0.7439 Intermediate Similarity NPC129042
0.7436 Intermediate Similarity NPC22079
0.7432 Intermediate Similarity NPC324149
0.743 Intermediate Similarity NPC284678
0.743 Intermediate Similarity NPC190007
0.7427 Intermediate Similarity NPC194640
0.7427 Intermediate Similarity NPC271734
0.7412 Intermediate Similarity NPC473320
0.7407 Intermediate Similarity NPC473868
0.7407 Intermediate Similarity NPC63157
0.7403 Intermediate Similarity NPC278434
0.7401 Intermediate Similarity NPC88363
0.7399 Intermediate Similarity NPC201700
0.7396 Intermediate Similarity NPC476116
0.7394 Intermediate Similarity NPC471944
0.7391 Intermediate Similarity NPC106937
0.7391 Intermediate Similarity NPC73767
0.7389 Intermediate Similarity NPC94943
0.7386 Intermediate Similarity NPC134586
0.738 Intermediate Similarity NPC18487
0.7368 Intermediate Similarity NPC475070
0.7368 Intermediate Similarity NPC41174
0.7363 Intermediate Similarity NPC32771
0.7356 Intermediate Similarity NPC194411
0.7346 Intermediate Similarity NPC469767
0.7346 Intermediate Similarity NPC469779
0.7346 Intermediate Similarity NPC469761
0.7346 Intermediate Similarity NPC469783
0.7346 Intermediate Similarity NPC469784
0.7346 Intermediate Similarity NPC469780
0.7346 Intermediate Similarity NPC469768
0.7345 Intermediate Similarity NPC211997
0.7345 Intermediate Similarity NPC96890
0.7345 Intermediate Similarity NPC248454
0.7341 Intermediate Similarity NPC54988
0.7341 Intermediate Similarity NPC109447
0.7333 Intermediate Similarity NPC469592
0.7333 Intermediate Similarity NPC471080
0.733 Intermediate Similarity NPC472586
0.7326 Intermediate Similarity NPC472587
0.7326 Intermediate Similarity NPC131887
0.7326 Intermediate Similarity NPC162268
0.7322 Intermediate Similarity NPC469470
0.7322 Intermediate Similarity NPC469501
0.7318 Intermediate Similarity NPC233936
0.7314 Intermediate Similarity NPC6982
0.7312 Intermediate Similarity NPC205403
0.7312 Intermediate Similarity NPC242209
0.7303 Intermediate Similarity NPC176199
0.7303 Intermediate Similarity NPC215795
0.7303 Intermediate Similarity NPC219336
0.7302 Intermediate Similarity NPC300183
0.7301 Intermediate Similarity NPC469766
0.7299 Intermediate Similarity NPC154293
0.7297 Intermediate Similarity NPC307963
0.7293 Intermediate Similarity NPC280290
0.7289 Intermediate Similarity NPC471957
0.7287 Intermediate Similarity NPC293917
0.7287 Intermediate Similarity NPC32200
0.7284 Intermediate Similarity NPC110126
0.7283 Intermediate Similarity NPC243716
0.7283 Intermediate Similarity NPC470508
0.7278 Intermediate Similarity NPC472110
0.7278 Intermediate Similarity NPC212535
0.7278 Intermediate Similarity NPC475450
0.7278 Intermediate Similarity NPC472109
0.7273 Intermediate Similarity NPC156704
0.7273 Intermediate Similarity NPC232130
0.7273 Intermediate Similarity NPC204141
0.7268 Intermediate Similarity NPC128751
0.7268 Intermediate Similarity NPC246700
0.7268 Intermediate Similarity NPC175474
0.7267 Intermediate Similarity NPC84911
0.7263 Intermediate Similarity NPC198339
0.7258 Intermediate Similarity NPC276517
0.7251 Intermediate Similarity NPC475990
0.7251 Intermediate Similarity NPC474880
0.7251 Intermediate Similarity NPC221786
0.7247 Intermediate Similarity NPC151939
0.7247 Intermediate Similarity NPC15573
0.7247 Intermediate Similarity NPC68354
0.7247 Intermediate Similarity NPC111275
0.7247 Intermediate Similarity NPC326575
0.7247 Intermediate Similarity NPC183662
0.7247 Intermediate Similarity NPC217372
0.7239 Intermediate Similarity NPC115611
0.7238 Intermediate Similarity NPC228835
0.7234 Intermediate Similarity NPC265576
0.7234 Intermediate Similarity NPC473640
0.7232 Intermediate Similarity NPC37423
0.7232 Intermediate Similarity NPC275305
0.7228 Intermediate Similarity NPC106833
0.7228 Intermediate Similarity NPC95783
0.7228 Intermediate Similarity NPC469497
0.7225 Intermediate Similarity NPC476098
0.7225 Intermediate Similarity NPC271797
0.7225 Intermediate Similarity NPC98715
0.7225 Intermediate Similarity NPC21174
0.7222 Intermediate Similarity NPC71037
0.7216 Intermediate Similarity NPC470498
0.7209 Intermediate Similarity NPC229173

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC476118 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
1.0 High Similarity NPD5138 Approved
1.0 High Similarity NPD5140 Approved
0.8963 High Similarity NPD5596 Phase 2
0.88 High Similarity NPD1592 Phase 3
0.8488 Intermediate Similarity NPD5592 Clinical (unspecified phase)
0.8242 Intermediate Similarity NPD2844 Phase 3
0.8098 Intermediate Similarity NPD1554 Clinical (unspecified phase)
0.8084 Intermediate Similarity NPD1326 Approved
0.8084 Intermediate Similarity NPD1325 Approved
0.8047 Intermediate Similarity NPD5065 Approved
0.8012 Intermediate Similarity NPD2882 Phase 1
0.8 Intermediate Similarity NPD6141 Clinical (unspecified phase)
0.7989 Intermediate Similarity NPD6449 Clinical (unspecified phase)
0.795 Intermediate Similarity NPD4463 Approved
0.795 Intermediate Similarity NPD4462 Approved
0.7709 Intermediate Similarity NPD1043 Phase 3
0.7683 Intermediate Similarity NPD6158 Phase 2
0.7683 Intermediate Similarity NPD6476 Clinical (unspecified phase)
0.7661 Intermediate Similarity NPD4184 Clinical (unspecified phase)
0.7644 Intermediate Similarity NPD2144 Approved
0.763 Intermediate Similarity NPD6492 Phase 2
0.7614 Intermediate Similarity NPD7867 Phase 1
0.7609 Intermediate Similarity NPD3230 Clinical (unspecified phase)
0.7588 Intermediate Similarity NPD5744 Clinical (unspecified phase)
0.7586 Intermediate Similarity NPD2380 Approved
0.7586 Intermediate Similarity NPD2381 Approved
0.7586 Intermediate Similarity NPD2382 Approved
0.7578 Intermediate Similarity NPD6506 Clinical (unspecified phase)
0.7514 Intermediate Similarity NPD3038 Discontinued
0.75 Intermediate Similarity NPD4703 Approved
0.75 Intermediate Similarity NPD4702 Approved
0.7486 Intermediate Similarity NPD5575 Clinical (unspecified phase)
0.7473 Intermediate Similarity NPD5912 Clinical (unspecified phase)
0.7473 Intermediate Similarity NPD5913 Phase 3
0.7458 Intermediate Similarity NPD8464 Clinical (unspecified phase)
0.7458 Intermediate Similarity NPD6595 Phase 3
0.7453 Intermediate Similarity NPD3943 Clinical (unspecified phase)
0.7418 Intermediate Similarity NPD5117 Phase 2
0.741 Intermediate Similarity NPD3835 Phase 3
0.741 Intermediate Similarity NPD3833 Phase 3
0.7399 Intermediate Similarity NPD5069 Clinical (unspecified phase)
0.7396 Intermediate Similarity NPD6545 Clinical (unspecified phase)
0.7391 Intermediate Similarity NPD802 Phase 2
0.7389 Intermediate Similarity NPD6344 Clinical (unspecified phase)
0.7382 Intermediate Similarity NPD6838 Clinical (unspecified phase)
0.7368 Intermediate Similarity NPD972 Clinical (unspecified phase)
0.7366 Intermediate Similarity NPD7948 Phase 1
0.7353 Intermediate Similarity NPD5255 Approved
0.733 Intermediate Similarity NPD6403 Clinical (unspecified phase)
0.7318 Intermediate Similarity NPD4203 Approved
0.7318 Intermediate Similarity NPD4204 Approved
0.7317 Intermediate Similarity NPD5254 Discontinued
0.7308 Intermediate Similarity NPD2383 Phase 1
0.7303 Intermediate Similarity NPD3417 Phase 1
0.7303 Intermediate Similarity NPD4079 Approved
0.7303 Intermediate Similarity NPD4076 Approved
0.7302 Intermediate Similarity NPD4511 Phase 1
0.7301 Intermediate Similarity NPD3834 Clinical (unspecified phase)
0.7297 Intermediate Similarity NPD1038 Approved
0.7293 Intermediate Similarity NPD6610 Clinical (unspecified phase)
0.7288 Intermediate Similarity NPD5100 Phase 3
0.7287 Intermediate Similarity NPD7621 Clinical (unspecified phase)
0.7284 Intermediate Similarity NPD786 Approved
0.7283 Intermediate Similarity NPD6630 Clinical (unspecified phase)
0.7282 Intermediate Similarity NPD8093 Discontinued
0.7273 Intermediate Similarity NPD4112 Clinical (unspecified phase)
0.7268 Intermediate Similarity NPD8110 Clinical (unspecified phase)
0.7268 Intermediate Similarity NPD6965 Clinical (unspecified phase)
0.7263 Intermediate Similarity NPD6452 Discontinued
0.7256 Intermediate Similarity NPD4637 Clinical (unspecified phase)
0.7253 Intermediate Similarity NPD706 Phase 1
0.7247 Intermediate Similarity NPD3505 Approved
0.7247 Intermediate Similarity NPD3506 Approved
0.7243 Intermediate Similarity NPD3404 Approved
0.7219 Intermediate Similarity NPD2837 Discontinued
0.7216 Intermediate Similarity NPD5934 Clinical (unspecified phase)
0.7207 Intermediate Similarity NPD8386 Phase 2
0.7205 Intermediate Similarity NPD198 Clinical (unspecified phase)
0.7202 Intermediate Similarity NPD8322 Phase 2
0.7195 Intermediate Similarity NPD5020 Approved
0.7195 Intermediate Similarity NPD6301 Phase 2
0.7193 Intermediate Similarity NPD4669 Clinical (unspecified phase)
0.7193 Intermediate Similarity NPD4670 Clinical (unspecified phase)
0.7193 Intermediate Similarity NPD4671 Clinical (unspecified phase)
0.7191 Intermediate Similarity NPD749 Clinical (unspecified phase)
0.7182 Intermediate Similarity NPD5728 Clinical (unspecified phase)
0.7182 Intermediate Similarity NPD2092 Phase 2
0.7182 Intermediate Similarity NPD2095 Phase 2
0.7182 Intermediate Similarity NPD2094 Phase 2
0.7175 Intermediate Similarity NPD3224 Phase 2
0.7157 Intermediate Similarity NPD8094 Discontinued
0.7152 Intermediate Similarity NPD3717 Discontinued
0.7152 Intermediate Similarity NPD3654 Approved
0.7151 Intermediate Similarity NPD6203 Clinical (unspecified phase)
0.7143 Intermediate Similarity NPD2096 Phase 2
0.7143 Intermediate Similarity NPD3100 Discontinued
0.7143 Intermediate Similarity NPD2091 Phase 2
0.7135 Intermediate Similarity NPD482 Approved
0.7135 Intermediate Similarity NPD4128 Approved
0.712 Intermediate Similarity NPD8431 Approved
0.712 Intermediate Similarity NPD4948 Discontinued
0.7112 Intermediate Similarity NPD3403 Clinical (unspecified phase)
0.7107 Intermediate Similarity NPD3330 Phase 1
0.7105 Intermediate Similarity NPD8395 Approved
0.7105 Intermediate Similarity NPD1768 Approved
0.7105 Intermediate Similarity NPD8396 Approved
0.7104 Intermediate Similarity NPD6227 Discontinued
0.7104 Intermediate Similarity NPD7424 Clinical (unspecified phase)
0.7101 Intermediate Similarity NPD2172 Phase 1
0.7098 Intermediate Similarity NPD5901 Discontinued
0.7093 Intermediate Similarity NPD4326 Phase 2
0.7091 Intermediate Similarity NPD1722 Approved
0.7077 Intermediate Similarity NPD5658 Approved
0.7074 Intermediate Similarity NPD3324 Clinical (unspecified phase)
0.7074 Intermediate Similarity NPD3791 Clinical (unspecified phase)
0.7072 Intermediate Similarity NPD5897 Approved
0.7072 Intermediate Similarity NPD5899 Approved
0.7072 Intermediate Similarity NPD5898 Approved
0.7072 Intermediate Similarity NPD6277 Clinical (unspecified phase)
0.7068 Intermediate Similarity NPD484 Approved
0.7062 Intermediate Similarity NPD3003 Approved
0.7062 Intermediate Similarity NPD8403 Phase 1
0.7062 Intermediate Similarity NPD4862 Clinical (unspecified phase)
0.7056 Intermediate Similarity NPD7470 Discontinued
0.7056 Intermediate Similarity NPD4181 Approved
0.7056 Intermediate Similarity NPD6159 Phase 2
0.7053 Intermediate Similarity NPD53 Approved
0.7053 Intermediate Similarity NPD7777 Approved
0.7053 Intermediate Similarity NPD7778 Approved
0.7053 Intermediate Similarity NPD7946 Pre-registration
0.7043 Intermediate Similarity NPD4499 Approved
0.7041 Intermediate Similarity NPD4374 Clinical (unspecified phase)
0.7027 Intermediate Similarity NPD3486 Clinical (unspecified phase)
0.7024 Intermediate Similarity NPD1683 Approved
0.7021 Intermediate Similarity NPD1304 Clinical (unspecified phase)
0.7016 Intermediate Similarity NPD6999 Discontinued
0.7016 Intermediate Similarity NPD3825 Phase 3
0.7016 Intermediate Similarity NPD3814 Phase 1
0.7016 Intermediate Similarity NPD4118 Clinical (unspecified phase)
0.7016 Intermediate Similarity NPD7000 Clinical (unspecified phase)
0.7015 Intermediate Similarity NPD8405 Clinical (unspecified phase)
0.7011 Intermediate Similarity NPD3082 Discontinued
0.701 Intermediate Similarity NPD8098 Approved
0.701 Intermediate Similarity NPD5426 Phase 3
0.7006 Intermediate Similarity NPD5021 Discontinued
0.7006 Intermediate Similarity NPD5595 Clinical (unspecified phase)
0.7006 Intermediate Similarity NPD3813 Approved
0.7006 Intermediate Similarity NPD5862 Discovery
0.7 Intermediate Similarity NPD7081 Clinical (unspecified phase)
0.7 Intermediate Similarity NPD5003 Discontinued
0.6995 Remote Similarity NPD2391 Clinical (unspecified phase)
0.6993 Remote Similarity NPD2210 Approved
0.6993 Remote Similarity NPD2212 Approved
0.699 Remote Similarity NPD2510 Approved
0.699 Remote Similarity NPD2509 Approved
0.6984 Remote Similarity NPD3810 Clinical (unspecified phase)
0.6983 Remote Similarity NPD750 Phase 2
0.6976 Remote Similarity NPD4401 Phase 2
0.6976 Remote Similarity NPD6976 Clinical (unspecified phase)
0.6976 Remote Similarity NPD4403 Phase 3
0.6975 Remote Similarity NPD3385 Approved
0.6971 Remote Similarity NPD1684 Approved
0.6971 Remote Similarity NPD1685 Approved
0.6968 Remote Similarity NPD2127 Suspended
0.6965 Remote Similarity NPD7823 Clinical (unspecified phase)
0.6961 Remote Similarity NPD7865 Approved
0.6959 Remote Similarity NPD4886 Phase 2
0.6959 Remote Similarity NPD6176 Phase 1
0.6959 Remote Similarity NPD2121 Clinical (unspecified phase)
0.6954 Remote Similarity NPD704 Clinical (unspecified phase)
0.6952 Remote Similarity NPD3321 Discontinued
0.6951 Remote Similarity NPD1262 Discovery
0.6949 Remote Similarity NPD4554 Clinical (unspecified phase)
0.6949 Remote Similarity NPD2642 Approved
0.6949 Remote Similarity NPD2639 Approved
0.6946 Remote Similarity NPD3525 Discontinued
0.6944 Remote Similarity NPD5153 Clinical (unspecified phase)
0.6943 Remote Similarity NPD6145 Phase 1
0.6941 Remote Similarity NPD5546 Clinical (unspecified phase)
0.694 Remote Similarity NPD3178 Discontinued
0.694 Remote Similarity NPD4383 Clinical (unspecified phase)
0.6935 Remote Similarity NPD8096 Phase 3
0.6935 Remote Similarity NPD8097 Phase 3
0.6935 Remote Similarity NPD3961 Discontinued
0.6928 Remote Similarity NPD1649 Discontinued
0.6923 Remote Similarity NPD6148 Clinical (unspecified phase)
0.6923 Remote Similarity NPD7469 Discontinued
0.6923 Remote Similarity NPD8272 Phase 2
0.6923 Remote Similarity NPD5398 Clinical (unspecified phase)
0.6915 Remote Similarity NPD5082 Clinical (unspecified phase)
0.6915 Remote Similarity NPD5081 Phase 1
0.6914 Remote Similarity NPD1403 Approved
0.6914 Remote Similarity NPD6524 Clinical (unspecified phase)
0.6914 Remote Similarity NPD1404 Approved
0.6911 Remote Similarity NPD3830 Phase 1
0.691 Remote Similarity NPD4640 Approved
0.691 Remote Similarity NPD4639 Approved
0.691 Remote Similarity NPD4638 Approved
0.691 Remote Similarity NPD2185 Clinical (unspecified phase)
0.6908 Remote Similarity NPD6978 Phase 2

Structure

External Identifiers

PubChem CID   5329102
ChEMBL   CHEMBL535
ZINC  

Physicochemical Properties

Molecular Weight:  398.21
ALogP:  1.7674
MLogP:  3.11
XLogP:  4.4
# Rotatable Bonds:  14
Polar Surface Area:  84.21
# H-Bond Aceptor:  6
# H-Bond Donor:  3
# Rings:  3
# Heavy Atoms:  29

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