NPASS Natural Product

Natural Product: NPC94428

Natural Product ID:	NPC94428
Common Name:	K-252A
IUPAC Name:
Synonyms:	K-252A
Molecular Formula:	C27H21N3O5
Standard InCHIKey:	KOZFSFOOLUUIGY-SOLYNIJKSA-N
Standard InCHI:	InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
Canonical SMILES:	COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CN=C1O
First Find Year:
Max Developmental Stage:
Synthetic Gene Cluster:	BGC0000813;BGC0000814 ;

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO30978	Nocardiopsis sp. k-252a	Species	Nocardiopsaceae	Bacteria				PMID[3759657]

Biological Activity

Activity Type	# Activity
IC50	20
Ki	1
Others	471

Activity Type	# Activity
Individual Protein	454
Others	3
Protein Complex	27
Protein Family	8

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT1284	Protein Family	Protein kinase C (PKC)	Rattus norvegicus	IC50	=	250	nM	9301660
NPT316	Protein Family	Protein kinase C (PKC)	Homo sapiens	IC50	=	60	nM	10.1016/0960-894X(94)80024-3
NPT316	Protein Family	Protein kinase C (PKC)	Homo sapiens	IC50	=	250	nM	12270156
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	IC50	=	13	nM	12270156
NPT1478	Individual Protein	Vascular endothelial growth factor receptor 2	Homo sapiens	IC50	=	43	nM	12270156
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	IC50	=	22	nM	12270156
NPT316	Protein Family	Protein kinase C (PKC)	Homo sapiens	IC50	=	25	nM	10.1016/S0960-894X(01)80407-8
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	IC50	=	2.4	nM	9191963
NPT1284	Protein Family	Protein kinase C (PKC)	Rattus norvegicus	IC50	=	0.028	nM	9191963
NPT2543	Individual Protein	cAMP-dependent protein kinase alpha-catalytic subunit	Oryctolagus cuniculus	IC50	=	0.016	nM	9191963
NPT3325	Individual Protein	Myosin light chain kinase, smooth muscle	Gallus gallus	IC50	=	0.02	nM	9191963
NPT1284	Protein Family	Protein kinase C (PKC)	Rattus norvegicus	IC50	=	60	nM	10.1016/S0960-894X(01)80356-5
NPT1284	Protein Family	Protein kinase C (PKC)	Rattus norvegicus	IC50	=	60	nM	10.1016/S0960-894X(00)80013-X
NPT316	Protein Family	Protein kinase C (PKC)	Homo sapiens	IC50	=	33	nM	10.1016/S0960-894X(00)80167-5
NPT3605	Individual Protein	Protein kinase C gamma	Rattus norvegicus	IC50	=	470	nM	1732526
NPT2	Others	Unspecified		IC50	=	270	nM	1732526
NPT4086	Protein Complex	Phosphorylase kinase	Homo sapiens	IC50	=	1.7	nM	1732526
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	IC50	=	13	nM	15916429
NPT2	Others	Unspecified		IC50	=	250	nM	15916429
NPT1478	Individual Protein	Vascular endothelial growth factor receptor 2	Homo sapiens	IC50	=	43	nM	15916429
NPT2	Others	Unspecified		Ratio	=	19		15916429
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	Ki	=	20	nM	21130659
NPT3317	Individual Protein	Serine/threonine-protein kinase MARK1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3419	Individual Protein	Serine/threonine-protein kinase SRPK3	Homo sapiens	Residual Activity	=	11	%	23398362
NPT3284	Individual Protein	Serine/threonine-protein kinase NEK7	Homo sapiens	Residual Activity	=	103	%	23398362
NPT3214	Individual Protein	Tyrosine-protein kinase ABL2	Homo sapiens	Residual Activity	=	35	%	23398362
NPT3814	Protein Complex	Cyclin-dependent kinase 2/cyclin A	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1686	Individual Protein	Casein kinase I isoform gamma-3	Homo sapiens	Residual Activity	=	58	%	23398362
NPT3266	Individual Protein	Casein kinase I delta	Homo sapiens	Residual Activity	=	79	%	23398362
NPT1672	Individual Protein	CaM kinase I delta	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1721	Individual Protein	Death-associated protein kinase 1	Homo sapiens	Residual Activity	=	48	%	23398362
NPT3218	Individual Protein	Ephrin type-A receptor 4	Homo sapiens	Residual Activity	=	43	%	23398362
NPT3219	Individual Protein	Ephrin type-A receptor 5	Homo sapiens	Residual Activity	=	66	%	23398362
NPT3227	Individual Protein	Fibroblast growth factor receptor 3	Homo sapiens	Residual Activity	=	2	%	23398362
NPT14	Individual Protein	Tyrosine-protein kinase FYN	Homo sapiens	Residual Activity	=	4	%	23398362
NPT14	Individual Protein	Tyrosine-protein kinase FYN	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Residual Activity	=	4	%	23398362
NPT982	Individual Protein	Inhibitor of nuclear factor kappa B kinase alpha subunit	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3207	Individual Protein	c-Jun N-terminal kinase 3	Homo sapiens	Residual Activity	=	-3	%	23398362
NPT3207	Individual Protein	c-Jun N-terminal kinase 3	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT491	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3419	Individual Protein	Serine/threonine-protein kinase SRPK3	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1711	Individual Protein	Serine/threonine-protein kinase MST1	Homo sapiens	Residual Activity	=	5	%	23398362
NPT3284	Individual Protein	Serine/threonine-protein kinase NEK7	Homo sapiens	Residual Activity	=	95	%	23398362
NPT3285	Individual Protein	Serine/threonine protein kinase NLK	Homo sapiens	Residual Activity	=	42	%	23398362
NPT1432	Individual Protein	Serine/threonine-protein kinase Aurora-A	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1432	Individual Protein	Serine/threonine-protein kinase Aurora-A	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT2544	Protein Complex	Cyclin-dependent kinase 2/cyclin E	Homo sapiens	Residual Activity	=	6	%	23398362
NPT2544	Protein Complex	Cyclin-dependent kinase 2/cyclin E	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3266	Individual Protein	Casein kinase I delta	Homo sapiens	Residual Activity	=	37	%	23398362
NPT1721	Individual Protein	Death-associated protein kinase 1	Homo sapiens	Residual Activity	=	10	%	23398362
NPT3219	Individual Protein	Ephrin type-A receptor 5	Homo sapiens	Residual Activity	=	13	%	23398362
NPT3372	Individual Protein	Fibroblast growth factor receptor 4	Homo sapiens	Residual Activity	=	88	%	23398362
NPT3372	Individual Protein	Fibroblast growth factor receptor 4	Homo sapiens	Residual Activity	=	36	%	23398362
NPT3406	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	77	%	23398362
NPT981	Individual Protein	Inhibitor of nuclear factor kappa B kinase beta subunit	Homo sapiens	Residual Activity	=	17	%	23398362
NPT1478	Individual Protein	Vascular endothelial growth factor receptor 2	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3282	Individual Protein	Maternal embryonic leucine zipper kinase	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1711	Individual Protein	Serine/threonine-protein kinase MST1	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3285	Individual Protein	Serine/threonine protein kinase NLK	Homo sapiens	Residual Activity	=	10	%	23398362
NPT1433	Individual Protein	Serine/threonine-protein kinase Aurora-B	Homo sapiens	Residual Activity	=	0	%	23398362
NPT4087	Protein Complex	CDK3/cyclin E	Homo sapiens	Residual Activity	=	27	%	23398362
NPT1609	Protein Complex	Casein kinase II	Homo sapiens	Residual Activity	=	93	%	23398362
NPT1609	Protein Complex	Casein kinase II	Homo sapiens	Residual Activity	=	82	%	23398362
NPT3236	Individual Protein	Death-associated protein kinase 2	Homo sapiens	Residual Activity	=	12	%	23398362
NPT3236	Individual Protein	Death-associated protein kinase 2	Homo sapiens	Residual Activity	=	-3	%	23398362
NPT3211	Individual Protein	Ephrin type-A receptor 7	Homo sapiens	Residual Activity	=	32	%	23398362
NPT3211	Individual Protein	Ephrin type-A receptor 7	Homo sapiens	Residual Activity	=	4	%	23398362
NPT3244	Individual Protein	Tyrosine-protein kinase FER	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3406	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3457	Individual Protein	G protein-coupled receptor kinase 5	Homo sapiens	Residual Activity	=	40	%	23398362
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	14	%	23398362
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	23	%	23398362
NPT981	Individual Protein	Inhibitor of nuclear factor kappa B kinase beta subunit	Homo sapiens	Residual Activity	=	3	%	23398362
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	42	%	23398362
NPT1478	Individual Protein	Vascular endothelial growth factor receptor 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3242	Individual Protein	LIM domain kinase 1	Homo sapiens	Residual Activity	=	6	%	23398362
NPT3282	Individual Protein	Maternal embryonic leucine zipper kinase	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT3331	Individual Protein	Serine/threonine-protein kinase MST2	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3331	Individual Protein	Serine/threonine-protein kinase MST2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1442	Individual Protein	Serine/threonine-protein kinase PAK 2	Homo sapiens	Residual Activity	=	19	%	23398362
NPT1442	Individual Protein	Serine/threonine-protein kinase PAK 2	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3206	Individual Protein	Serine/threonine-protein kinase Aurora-C	Homo sapiens	Residual Activity	=	2	%	23398362
NPT4087	Protein Complex	CDK3/cyclin E	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Residual Activity	=	4	%	23398362
NPT3273	Individual Protein	Casein kinase II alpha (prime)	Homo sapiens	Residual Activity	=	108	%	23398362
NPT3336	Individual Protein	Serine/threonine-protein kinase DCLK2	Homo sapiens	Residual Activity	=	75	%	23398362
NPT3216	Individual Protein	Ephrin type-A receptor 8	Homo sapiens	Residual Activity	=	78	%	23398362
NPT3457	Individual Protein	G protein-coupled receptor kinase 5	Homo sapiens	Residual Activity	=	5	%	23398362
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	20	%	23398362
NPT3242	Individual Protein	LIM domain kinase 1	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3381	Individual Protein	Misshapen-like kinase 1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3381	Individual Protein	Misshapen-like kinase 1	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3332	Individual Protein	Serine/threonine-protein kinase 24	Homo sapiens	Residual Activity	=	14	%	23398362
NPT3247	Individual Protein	Serine/threonine-protein kinase PAK 3	Homo sapiens	Residual Activity	=	4	%	23398362
NPT3206	Individual Protein	Serine/threonine-protein kinase Aurora-C	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3273	Individual Protein	Casein kinase II alpha (prime)	Homo sapiens	Residual Activity	=	90	%	23398362
NPT1682	Individual Protein	Dual specificity protein kinase CLK2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3336	Individual Protein	Serine/threonine-protein kinase DCLK2	Homo sapiens	Residual Activity	=	41	%	23398362
NPT3303	Individual Protein	Discoidin domain-containing receptor 2	Homo sapiens	Residual Activity	=	56	%	23398362
NPT3216	Individual Protein	Ephrin type-A receptor 8	Homo sapiens	Residual Activity	=	40	%	23398362
NPT3212	Individual Protein	Ephrin type-B receptor 1	Homo sapiens	Residual Activity	=	39	%	23398362
NPT4088	Individual Protein	G protein-coupled receptor kinase 6	Homo sapiens	Residual Activity	=	36	%	23398362
NPT4088	Individual Protein	G protein-coupled receptor kinase 6	Homo sapiens	Residual Activity	=	5	%	23398362
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	7	%	23398362
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3279	Individual Protein	Serine/threonine-protein kinase 11	Homo sapiens	Residual Activity	=	97	%	23398362
NPT3279	Individual Protein	Serine/threonine-protein kinase 11	Homo sapiens	Residual Activity	=	74	%	23398362
NPT1691	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens	Residual Activity	=	26	%	23398362
NPT3332	Individual Protein	Serine/threonine-protein kinase 24	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3320	Individual Protein	Proto-oncogene tyrosine-protein kinase MER	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3245	Individual Protein	Tyrosine kinase non-receptor protein 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1659	Individual Protein	Tyrosine-protein kinase receptor UFO	Homo sapiens	Residual Activity	=	4	%	23398362
NPT1659	Individual Protein	Tyrosine-protein kinase receptor UFO	Homo sapiens	Residual Activity	=	-3	%	23398362
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Residual Activity	=	3	%	23398362
NPT1682	Individual Protein	Dual specificity protein kinase CLK2	Homo sapiens	Residual Activity	=	4	%	23398362
NPT3303	Individual Protein	Discoidin domain-containing receptor 2	Homo sapiens	Residual Activity	=	17	%	23398362
NPT3212	Individual Protein	Ephrin type-B receptor 1	Homo sapiens	Residual Activity	=	4	%	23398362
NPT3438	Individual Protein	G protein-coupled receptor kinase 7	Homo sapiens	Residual Activity	=	4	%	23398362
NPT3386	Individual Protein	Interleukin-1 receptor-associated kinase 1	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1707	Individual Protein	Serine/threonine-protein kinase 10	Homo sapiens	Residual Activity	=	3	%	23398362
NPT1691	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3320	Individual Protein	Proto-oncogene tyrosine-protein kinase MER	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1661	Individual Protein	ALK tyrosine kinase receptor	Homo sapiens	Residual Activity	=	10	%	23398362
NPT3215	Individual Protein	Tyrosine-protein kinase BRK	Homo sapiens	Residual Activity	=	19	%	23398362
NPT4089	Protein Complex	CDK6/cyclin D3	Homo sapiens	Residual Activity	=	15	%	23398362
NPT1683	Individual Protein	Dual specificity protein kinase CLK3	Homo sapiens	Residual Activity	=	72	%	23398362
NPT1683	Individual Protein	Dual specificity protein kinase CLK3	Homo sapiens	Residual Activity	=	33	%	23398362
NPT1688	Individual Protein	Myotonin-protein kinase	Homo sapiens	Residual Activity	=	116	%	23398362
NPT1688	Individual Protein	Myotonin-protein kinase	Homo sapiens	Residual Activity	=	65	%	23398362
NPT2941	Individual Protein	Ephrin type-B receptor 2	Homo sapiens	Residual Activity	=	114	%	23398362
NPT2941	Individual Protein	Ephrin type-B receptor 2	Homo sapiens	Residual Activity	=	55	%	23398362
NPT676	Individual Protein	Glycogen synthase kinase-3 alpha	Homo sapiens	Residual Activity	=	14	%	23398362
NPT3386	Individual Protein	Interleukin-1 receptor-associated kinase 1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3425	Individual Protein	Interleukin-1 receptor-associated kinase 4	Homo sapiens	Residual Activity	=	-2	%	23398362
NPT1707	Individual Protein	Serine/threonine-protein kinase 10	Homo sapiens	Residual Activity	=	1	%	23398362
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3441	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens	Residual Activity	=	7	%	23398362
NPT3441	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1337	Individual Protein	Hepatocyte growth factor receptor	Homo sapiens	Residual Activity	=	6	%	23398362
NPT1337	Individual Protein	Hepatocyte growth factor receptor	Homo sapiens	Residual Activity	=	13	%	23398362
NPT1661	Individual Protein	ALK tyrosine kinase receptor	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3215	Individual Protein	Tyrosine-protein kinase BRK	Homo sapiens	Residual Activity	=	1	%	23398362
NPT833	Individual Protein	Tyrosine-protein kinase BTK	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT4089	Protein Complex	CDK6/cyclin D3	Homo sapiens	Residual Activity	=	4	%	23398362
NPT4090	Protein Complex	Cyclin-dependent kinase 7/ cyclin H	Homo sapiens	Residual Activity	=	55	%	23398362
NPT3113	Individual Protein	Tyrosine-protein kinase CSK	Homo sapiens	Residual Activity	=	71	%	23398362
NPT1709	Individual Protein	Serine/threonine-protein kinase 17A	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3359	Individual Protein	Ephrin type-B receptor 3	Homo sapiens	Residual Activity	=	110	%	23398362
NPT3244	Individual Protein	Tyrosine-protein kinase FER	Homo sapiens	Residual Activity	=	0	%	23398362
NPT676	Individual Protein	Glycogen synthase kinase-3 alpha	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3425	Individual Protein	Interleukin-1 receptor-associated kinase 4	Homo sapiens	Residual Activity	=	0	%	23398362
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	9	%	23398362
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3213	Individual Protein	MAP kinase signal-integrating kinase 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3293	Individual Protein	Activin receptor type-1B	Homo sapiens	Residual Activity	=	24	%	23398362
NPT3293	Individual Protein	Activin receptor type-1B	Homo sapiens	Residual Activity	=	0	%	23398362
NPT4090	Protein Complex	Cyclin-dependent kinase 7/ cyclin H	Homo sapiens	Residual Activity	=	16	%	23398362
NPT3113	Individual Protein	Tyrosine-protein kinase CSK	Homo sapiens	Residual Activity	=	18	%	23398362
NPT3232	Individual Protein	CaM kinase I alpha	Homo sapiens	Residual Activity	=	6	%	23398362
NPT1709	Individual Protein	Serine/threonine-protein kinase 17A	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3399	Individual Protein	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3359	Individual Protein	Ephrin type-B receptor 3	Homo sapiens	Residual Activity	=	100	%	23398362
NPT1437	Individual Protein	Tyrosine-protein kinase FES	Homo sapiens	Residual Activity	=	7	%	23398362
NPT1437	Individual Protein	Tyrosine-protein kinase FES	Homo sapiens	Residual Activity	=	1	%	23398362
NPT591	Individual Protein	Glycogen synthase kinase-3 beta	Homo sapiens	Residual Activity	=	29	%	23398362
NPT591	Individual Protein	Glycogen synthase kinase-3 beta	Homo sapiens	Residual Activity	=	10	%	23398362
NPT3286	Individual Protein	Insulin receptor-related protein	Homo sapiens	Residual Activity	=	6	%	23398362
NPT3286	Individual Protein	Insulin receptor-related protein	Homo sapiens	Residual Activity	=	1	%	23398362
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	6	%	23398362
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	8	%	23398362
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3326	Individual Protein	Mitogen-activated protein kinase kinase kinase 9	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3333	Individual Protein	Muscle, skeletal receptor tyrosine protein kinase	Homo sapiens	Residual Activity	=	18	%	23398362
NPT4091	Protein Complex	AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT4091	Protein Complex	AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3312	Individual Protein	Tyrosine-protein kinase BLK	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3312	Individual Protein	Tyrosine-protein kinase BLK	Homo sapiens	Residual Activity	=	0	%	23398362
NPT4092	Protein Complex	CDK9/cyclin T1	Homo sapiens	Residual Activity	=	10	%	23398362
NPT4092	Protein Complex	CDK9/cyclin T1	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3232	Individual Protein	CaM kinase I alpha	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3399	Individual Protein	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Homo sapiens	Residual Activity	=	-4	%	23398362
NPT2572	Individual Protein	Ephrin type-B receptor 4	Homo sapiens	Residual Activity	=	71	%	23398362
NPT2572	Individual Protein	Ephrin type-B receptor 4	Homo sapiens	Residual Activity	=	22	%	23398362
NPT3112	Individual Protein	Tyrosine-protein kinase FGR	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3444	Individual Protein	Homeodomain-interacting protein kinase 1	Homo sapiens	Residual Activity	=	78	%	23398362
NPT1439	Individual Protein	Tyrosine-protein kinase ITK/TSK	Homo sapiens	Residual Activity	=	15	%	23398362
NPT3111	Individual Protein	Tyrosine-protein kinase Lyn	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3326	Individual Protein	Mitogen-activated protein kinase kinase kinase 9	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3333	Individual Protein	Muscle, skeletal receptor tyrosine protein kinase	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1767	Protein Complex	AMP-activated protein kinase, AMPK	Homo sapiens	Residual Activity	=	-5	%	23398362
NPT2750	Individual Protein	Tyrosine-protein kinase BMX	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1608	Individual Protein	Serine/threonine-protein kinase Chk1	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1608	Individual Protein	Serine/threonine-protein kinase Chk1	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT1630	Individual Protein	CaM kinase II beta	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1630	Individual Protein	CaM kinase II beta	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT285	Individual Protein	Epidermal growth factor receptor erbB1	Homo sapiens	Residual Activity	=	72	%	23398362
NPT285	Individual Protein	Epidermal growth factor receptor erbB1	Homo sapiens	Residual Activity	=	47	%	23398362
NPT1435	Individual Protein	Receptor protein-tyrosine kinase erbB-4	Homo sapiens	Residual Activity	=	64	%	23398362
NPT3112	Individual Protein	Tyrosine-protein kinase FGR	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT301	Individual Protein	Vascular endothelial growth factor receptor 1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3444	Individual Protein	Homeodomain-interacting protein kinase 1	Homo sapiens	Residual Activity	=	15	%	23398362
NPT3432	Individual Protein	Homeodomain-interacting protein kinase 2	Homo sapiens	Residual Activity	=	22	%	23398362
NPT1439	Individual Protein	Tyrosine-protein kinase ITK/TSK	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3246	Individual Protein	Tyrosine-protein kinase JAK2	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3111	Individual Protein	Tyrosine-protein kinase Lyn	Homo sapiens	Residual Activity	=	0	%	23398362
NPT281	Individual Protein	MAP kinase ERK1	Homo sapiens	Residual Activity	=	10	%	23398362
NPT3329	Individual Protein	Serine/threonine-protein kinase MRCK-A	Homo sapiens	Residual Activity	=	71	%	23398362
NPT3329	Individual Protein	Serine/threonine-protein kinase MRCK-A	Homo sapiens	Residual Activity	=	23	%	23398362
NPT3443	Individual Protein	Serine/threonine-protein kinase Nek11	Homo sapiens	Residual Activity	=	34	%	23398362
NPT3443	Individual Protein	Serine/threonine-protein kinase Nek11	Homo sapiens	Residual Activity	=	9	%	23398362
NPT1767	Protein Complex	AMP-activated protein kinase, AMPK	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1660	Individual Protein	NUAK family SNF1-like kinase 1	Homo sapiens	Residual Activity	=	1	%	23398362
NPT2750	Individual Protein	Tyrosine-protein kinase BMX	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3315	Individual Protein	BR serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT1680	Individual Protein	Serine/threonine-protein kinase Chk2	Homo sapiens	Residual Activity	=	3	%	23398362
NPT1676	Individual Protein	CaM kinase II gamma	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3354	Individual Protein	Ephrin type-A receptor 1	Homo sapiens	Residual Activity	=	3	%	23398362
NPT1435	Individual Protein	Receptor protein-tyrosine kinase erbB-4	Homo sapiens	Residual Activity	=	19	%	23398362
NPT1436	Individual Protein	Focal adhesion kinase 1	Homo sapiens	Residual Activity	=	39	%	23398362
NPT3432	Individual Protein	Homeodomain-interacting protein kinase 2	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT3246	Individual Protein	Tyrosine-protein kinase JAK2	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT281	Individual Protein	MAP kinase ERK1	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT3330	Individual Protein	Serine/threonine-protein kinase MRCK beta	Homo sapiens	Residual Activity	=	33	%	23398362
NPT1658	Individual Protein	Serine/threonine-protein kinase NEK2	Homo sapiens	Residual Activity	=	75	%	23398362
NPT3315	Individual Protein	BR serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1680	Individual Protein	Serine/threonine-protein kinase Chk2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1684	Individual Protein	Casein kinase I gamma 1	Homo sapiens	Residual Activity	=	93	%	23398362
NPT1676	Individual Protein	CaM kinase II gamma	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1675	Individual Protein	CaM kinase II delta	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3354	Individual Protein	Ephrin type-A receptor 1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3225	Individual Protein	Ephrin type-A receptor 2	Homo sapiens	Residual Activity	=	44	%	23398362
NPT1436	Individual Protein	Focal adhesion kinase 1	Homo sapiens	Residual Activity	=	5	%	23398362
NPT1650	Individual Protein	Tyrosine-protein kinase receptor FLT3	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1650	Individual Protein	Tyrosine-protein kinase receptor FLT3	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3409	Individual Protein	Homeodomain-interacting protein kinase 3	Homo sapiens	Residual Activity	=	54	%	23398362
NPT3409	Individual Protein	Homeodomain-interacting protein kinase 3	Homo sapiens	Residual Activity	=	-4	%	23398362
NPT1440	Individual Protein	Tyrosine-protein kinase JAK3	Homo sapiens	Residual Activity	=	0	%	23398362
NPT282	Individual Protein	MAP kinase ERK2	Homo sapiens	Residual Activity	=	5	%	23398362
NPT282	Individual Protein	MAP kinase ERK2	Homo sapiens	Residual Activity	=	-3	%	23398362
NPT3330	Individual Protein	Serine/threonine-protein kinase MRCK beta	Homo sapiens	Residual Activity	=	5	%	23398362
NPT1613	Individual Protein	Ribosomal protein S6 kinase alpha 5	Homo sapiens	Residual Activity	=	5	%	23398362
NPT1658	Individual Protein	Serine/threonine-protein kinase NEK2	Homo sapiens	Residual Activity	=	29	%	23398362
NPT3391	Individual Protein	Serine/threonine-protein kinase Nek3	Homo sapiens	Residual Activity	=	65	%	23398362
NPT1431	Individual Protein	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3344	Individual Protein	BR serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3344	Individual Protein	BR serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1684	Individual Protein	Casein kinase I gamma 1	Homo sapiens	Residual Activity	=	57	%	23398362
NPT1675	Individual Protein	CaM kinase II delta	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3225	Individual Protein	Ephrin type-A receptor 2	Homo sapiens	Residual Activity	=	8	%	23398362
NPT1480	Individual Protein	Fibroblast growth factor receptor 1	Homo sapiens	Residual Activity	=	10	%	23398362
NPT1480	Individual Protein	Fibroblast growth factor receptor 1	Homo sapiens	Residual Activity	=	11	%	23398362
NPT2573	Individual Protein	Vascular endothelial growth factor receptor 3	Homo sapiens	Residual Activity	=	0	%	23398362
NPT4093	Individual Protein	Serine/threonine-protein kinase haspin	Homo sapiens	Residual Activity	=	8	%	23398362
NPT1426	Individual Protein	c-Jun N-terminal kinase 1	Homo sapiens	Residual Activity	=	-12	%	23398362
NPT1441	Individual Protein	MAP kinase-activated protein kinase 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1613	Individual Protein	Ribosomal protein S6 kinase alpha 5	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3391	Individual Protein	Serine/threonine-protein kinase Nek3	Homo sapiens	Residual Activity	=	53	%	23398362
NPT2729	Individual Protein	Tyrosine-protein kinase ABL	Homo sapiens	Residual Activity	=	80	%	23398362
NPT1570	Protein Complex	Cyclin-dependent kinase 1/cyclin B	Homo sapiens	Residual Activity	=	5	%	23398362
NPT1685	Individual Protein	Casein kinase I gamma 2	Homo sapiens	Residual Activity	=	101	%	23398362
NPT1685	Individual Protein	Casein kinase I gamma 2	Homo sapiens	Residual Activity	=	60	%	23398362
NPT1677	Individual Protein	CaM kinase IV	Homo sapiens	Residual Activity	=	24	%	23398362
NPT1677	Individual Protein	CaM kinase IV	Homo sapiens	Residual Activity	=	11	%	23398362
NPT3217	Individual Protein	Ephrin type-A receptor 3	Homo sapiens	Residual Activity	=	42	%	23398362
NPT3217	Individual Protein	Ephrin type-A receptor 3	Homo sapiens	Residual Activity	=	5	%	23398362
NPT1481	Individual Protein	Fibroblast growth factor receptor 2	Homo sapiens	Residual Activity	=	20	%	23398362
NPT2573	Individual Protein	Vascular endothelial growth factor receptor 3	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3267	Individual Protein	Macrophage colony stimulating factor receptor	Homo sapiens	Residual Activity	=	2	%	23398362
NPT4093	Individual Protein	Serine/threonine-protein kinase haspin	Homo sapiens	Residual Activity	=	5	%	23398362
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Residual Activity	=	3	%	23398362
NPT1426	Individual Protein	c-Jun N-terminal kinase 1	Homo sapiens	Residual Activity	=	-20	%	23398362
NPT1427	Individual Protein	c-Jun N-terminal kinase 2	Homo sapiens	Residual Activity	=	5	%	23398362
NPT1441	Individual Protein	MAP kinase-activated protein kinase 2	Homo sapiens	Residual Activity	=	-6	%	23398362
NPT3461	Individual Protein	MAP kinase-activated protein kinase 3	Homo sapiens	Residual Activity	=	47	%	23398362
NPT3374	Individual Protein	Ribosomal protein S6 kinase alpha 4	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT3374	Individual Protein	Ribosomal protein S6 kinase alpha 4	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1657	Individual Protein	Serine/threonine-protein kinase NEK6	Homo sapiens	Residual Activity	=	104	%	23398362
NPT1657	Individual Protein	Serine/threonine-protein kinase NEK6	Homo sapiens	Residual Activity	=	120	%	23398362
NPT2729	Individual Protein	Tyrosine-protein kinase ABL	Homo sapiens	Residual Activity	=	51	%	23398362
NPT3214	Individual Protein	Tyrosine-protein kinase ABL2	Homo sapiens	Residual Activity	=	79	%	23398362
NPT1570	Protein Complex	Cyclin-dependent kinase 1/cyclin B	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT3814	Protein Complex	Cyclin-dependent kinase 2/cyclin A	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1686	Individual Protein	Casein kinase I isoform gamma-3	Homo sapiens	Residual Activity	=	99	%	23398362
NPT1672	Individual Protein	CaM kinase I delta	Homo sapiens	Residual Activity	=	5	%	23398362
NPT3218	Individual Protein	Ephrin type-A receptor 4	Homo sapiens	Residual Activity	=	83	%	23398362
NPT1481	Individual Protein	Fibroblast growth factor receptor 2	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3227	Individual Protein	Fibroblast growth factor receptor 3	Homo sapiens	Residual Activity	=	17	%	23398362
NPT3267	Individual Protein	Macrophage colony stimulating factor receptor	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	3	%	23398362
NPT982	Individual Protein	Inhibitor of nuclear factor kappa B kinase alpha subunit	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1427	Individual Protein	c-Jun N-terminal kinase 2	Homo sapiens	Residual Activity	=	-11	%	23398362
NPT3461	Individual Protein	MAP kinase-activated protein kinase 3	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1699	Individual Protein	3-phosphoinositide dependent protein kinase-1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1703	Individual Protein	cAMP-dependent protein kinase alpha-catalytic subunit	Homo sapiens	Residual Activity	=	7	%	23398362
NPT3124	Individual Protein	Protein kinase C eta	Homo sapiens	Residual Activity	=	7	%	23398362
NPT887	Individual Protein	Protein kinase C theta	Homo sapiens	Residual Activity	=	10	%	23398362
NPT1700	Individual Protein	Serine/threonine-protein kinase PIM2	Homo sapiens	Residual Activity	=	-2	%	23398362
NPT3277	Individual Protein	Tyrosine-protein kinase receptor TYRO3	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3349	Individual Protein	Serine/threonine-protein kinase SIK1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3269	Individual Protein	Serine/threonine-protein kinase tousled-like 2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3269	Individual Protein	Serine/threonine-protein kinase tousled-like 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT4094	Individual Protein	Serine/threonine-protein kinase WNK3	Homo sapiens	Residual Activity	=	70	%	23398362
NPT1703	Individual Protein	cAMP-dependent protein kinase alpha-catalytic subunit	Homo sapiens	Residual Activity	=	3	%	23398362
NPT887	Individual Protein	Protein kinase C theta	Homo sapiens	Residual Activity	=	5	%	23398362
NPT1701	Individual Protein	Serine/threonine-protein kinase PIM3	Homo sapiens	Residual Activity	=	31	%	23398362
NPT1701	Individual Protein	Serine/threonine-protein kinase PIM3	Homo sapiens	Residual Activity	=	5	%	23398362
NPT3106	Individual Protein	Ribosomal protein S6 kinase alpha 1	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3106	Individual Protein	Ribosomal protein S6 kinase alpha 1	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3291	Individual Protein	Serine/threonine-protein kinase SRPK1	Homo sapiens	Residual Activity	=	67	%	23398362
NPT3299	Individual Protein	Testis-specific serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT4094	Individual Protein	Serine/threonine-protein kinase WNK3	Homo sapiens	Residual Activity	=	8	%	23398362
NPT1663	Individual Protein	Tyrosine-protein kinase YES	Homo sapiens	Residual Activity	=	11	%	23398362
NPT728	Individual Protein	Serine/threonine-protein kinase AKT	Homo sapiens	Residual Activity	=	101	%	23398362
NPT728	Individual Protein	Serine/threonine-protein kinase AKT	Homo sapiens	Residual Activity	=	37	%	23398362
NPT3394	Individual Protein	Protein kinase C iota	Homo sapiens	Residual Activity	=	107	%	23398362
NPT3394	Individual Protein	Protein kinase C iota	Homo sapiens	Residual Activity	=	69	%	23398362
NPT831	Individual Protein	Serine/threonine-protein kinase PLK1	Homo sapiens	Residual Activity	=	50	%	23398362
NPT1705	Individual Protein	Ribosomal protein S6 kinase alpha 3	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3291	Individual Protein	Serine/threonine-protein kinase SRPK1	Homo sapiens	Residual Activity	=	14	%	23398362
NPT3292	Individual Protein	Serine/threonine-protein kinase SRPK2	Homo sapiens	Residual Activity	=	97	%	23398362
NPT3299	Individual Protein	Testis-specific serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3462	Individual Protein	Testis-specific serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	8	%	23398362
NPT1663	Individual Protein	Tyrosine-protein kinase YES	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1430	Individual Protein	Serine/threonine-protein kinase AKT2	Homo sapiens	Residual Activity	=	67	%	23398362
NPT3364	Individual Protein	Protein kinase C mu	Homo sapiens	Residual Activity	=	1	%	23398362
NPT831	Individual Protein	Serine/threonine-protein kinase PLK1	Homo sapiens	Residual Activity	=	17	%	23398362
NPT3358	Individual Protein	Serine/threonine-protein kinase PLK3	Homo sapiens	Residual Activity	=	90	%	23398362
NPT3234	Individual Protein	Ribosomal protein S6 kinase alpha 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3292	Individual Protein	Serine/threonine-protein kinase SRPK2	Homo sapiens	Residual Activity	=	52	%	23398362
NPT3462	Individual Protein	Testis-specific serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3259	Individual Protein	Tyrosine-protein kinase ZAP-70	Homo sapiens	Residual Activity	=	16	%	23398362
NPT3259	Individual Protein	Tyrosine-protein kinase ZAP-70	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1430	Individual Protein	Serine/threonine-protein kinase AKT2	Homo sapiens	Residual Activity	=	22	%	23398362
NPT2546	Individual Protein	Serine/threonine-protein kinase AKT3	Homo sapiens	Residual Activity	=	11	%	23398362
NPT3364	Individual Protein	Protein kinase C mu	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3358	Individual Protein	Serine/threonine-protein kinase PLK3	Homo sapiens	Residual Activity	=	54	%	23398362
NPT3234	Individual Protein	Ribosomal protein S6 kinase alpha 2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3296	Individual Protein	Serine/threonine-protein kinase 33	Homo sapiens	Residual Activity	=	7	%	23398362
NPT3296	Individual Protein	Serine/threonine-protein kinase 33	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3351	Individual Protein	Tyrosine-protein kinase TEC	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3351	Individual Protein	Tyrosine-protein kinase TEC	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1687	Individual Protein	Death-associated protein kinase 3	Homo sapiens	Residual Activity	=	12	%	23398362
NPT3247	Individual Protein	Serine/threonine-protein kinase PAK 3	Homo sapiens	Residual Activity	=	3	%	23398362
NPT1695	Individual Protein	Serine/threonine-protein kinase PAK 4	Homo sapiens	Residual Activity	=	3	%	23398362
NPT2546	Individual Protein	Serine/threonine-protein kinase AKT3	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3365	Individual Protein	Serine/threonine-protein kinase D2	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3365	Individual Protein	Serine/threonine-protein kinase D2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3262	Individual Protein	Serine/threonine-protein kinase PRKX	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3262	Individual Protein	Serine/threonine-protein kinase PRKX	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3254	Individual Protein	Ribosomal protein S6 kinase alpha 6	Homo sapiens	Residual Activity	=	-2	%	23398362
NPT3254	Individual Protein	Ribosomal protein S6 kinase alpha 6	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3414	Individual Protein	Serine/threonine-protein kinase PLK2	Homo sapiens	Residual Activity	=	72	%	23398362
NPT2576	Individual Protein	Tyrosine-protein kinase TIE-2	Homo sapiens	Residual Activity	=	20	%	23398362
NPT1687	Individual Protein	Death-associated protein kinase 3	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1424	Individual Protein	Serine/threonine-protein kinase RAF	Homo sapiens	Residual Activity	=	78	%	23398362
NPT1695	Individual Protein	Serine/threonine-protein kinase PAK 4	Homo sapiens	Residual Activity	=	0	%	23398362
NPT182	Individual Protein	Protein kinase C alpha	Homo sapiens	Residual Activity	=	19	%	23398362
NPT182	Individual Protein	Protein kinase C alpha	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	10	%	23398362
NPT3263	Individual Protein	Protein tyrosine kinase 2 beta	Homo sapiens	Residual Activity	=	3	%	23398362
NPT283	Individual Protein	MAP kinase p38 alpha	Homo sapiens	Residual Activity	=	92	%	23398362
NPT3414	Individual Protein	Serine/threonine-protein kinase PLK2	Homo sapiens	Residual Activity	=	36	%	23398362
NPT1449	Individual Protein	Tyrosine-protein kinase SYK	Homo sapiens	Residual Activity	=	1	%	23398362
NPT2576	Individual Protein	Tyrosine-protein kinase TIE-2	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	Residual Activity	=	0	%	23398362
NPT1424	Individual Protein	Serine/threonine-protein kinase RAF	Homo sapiens	Residual Activity	=	69	%	23398362
NPT1696	Individual Protein	Serine/threonine-protein kinase PAK7	Homo sapiens	Residual Activity	=	6	%	23398362
NPT1696	Individual Protein	Serine/threonine-protein kinase PAK7	Homo sapiens	Residual Activity	=	1	%	23398362
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	53	%	23398362
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	9	%	23398362
NPT3263	Individual Protein	Protein tyrosine kinase 2 beta	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT1447	Individual Protein	Serine/threonine-protein kinase RIPK2	Homo sapiens	Residual Activity	=	5	%	23398362
NPT283	Individual Protein	MAP kinase p38 alpha	Homo sapiens	Residual Activity	=	67	%	23398362
NPT1616	Individual Protein	MAP kinase p38 beta	Homo sapiens	Residual Activity	=	77	%	23398362
NPT1449	Individual Protein	Tyrosine-protein kinase SYK	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1479	Individual Protein	Stem cell growth factor receptor	Homo sapiens	Residual Activity	=	76	%	23398362
NPT1479	Individual Protein	Stem cell growth factor receptor	Homo sapiens	Residual Activity	=	20	%	23398362
NPT1697	Individual Protein	Serine/threonine-protein kinase PAK6	Homo sapiens	Residual Activity	=	0	%	23398362
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	13	%	23398362
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	67	%	23398362
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1447	Individual Protein	Serine/threonine-protein kinase RIPK2	Homo sapiens	Residual Activity	=	3	%	23398362
NPT1616	Individual Protein	MAP kinase p38 beta	Homo sapiens	Residual Activity	=	29	%	23398362
NPT3442	Individual Protein	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT3442	Individual Protein	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens	Residual Activity	=	-5	%	23398362
NPT3270	Individual Protein	Neurotrophic tyrosine kinase receptor type 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT36	Individual Protein	Tyrosine-protein kinase SRC	Homo sapiens	Residual Activity	=	35	%	23398362
NPT1697	Individual Protein	Serine/threonine-protein kinase PAK6	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	18	%	23398362
NPT1612	Individual Protein	MAP kinase-activated protein kinase 5	Homo sapiens	Residual Activity	=	19	%	23398362
NPT1612	Individual Protein	MAP kinase-activated protein kinase 5	Homo sapiens	Residual Activity	=	0	%	23398362
NPT592	Individual Protein	Rho-associated protein kinase 1	Homo sapiens	Residual Activity	=	50	%	23398362
NPT592	Individual Protein	Rho-associated protein kinase 1	Homo sapiens	Residual Activity	=	12	%	23398362
NPT1615	Individual Protein	MAP kinase p38 gamma	Homo sapiens	Residual Activity	=	23	%	23398362
NPT3431	Individual Protein	Serine/threonine-protein kinase TAO1	Homo sapiens	Residual Activity	=	5	%	23398362
NPT3272	Individual Protein	Tyrosine-protein kinase TXK	Homo sapiens	Residual Activity	=	35	%	23398362
NPT36	Individual Protein	Tyrosine-protein kinase SRC	Homo sapiens	Residual Activity	=	5	%	23398362
NPT1344	Individual Protein	Serine/threonine-protein kinase EEF2K	Homo sapiens	Residual Activity	=	124	%	23398362
NPT3235	Individual Protein	MAP/microtubule affinity-regulating kinase 2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3235	Individual Protein	MAP/microtubule affinity-regulating kinase 2	Homo sapiens	Residual Activity	=	-2	%	23398362
NPT880	Individual Protein	Protein kinase C gamma	Homo sapiens	Residual Activity	=	19	%	23398362
NPT880	Individual Protein	Protein kinase C gamma	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3357	Individual Protein	Protein kinase N2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3107	Individual Protein	Rho-associated protein kinase 2	Homo sapiens	Residual Activity	=	15	%	23398362
NPT1615	Individual Protein	MAP kinase p38 gamma	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1614	Individual Protein	MAP kinase p38 delta	Homo sapiens	Residual Activity	=	58	%	23398362
NPT3431	Individual Protein	Serine/threonine-protein kinase TAO1	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3426	Individual Protein	Serine/threonine-protein kinase TAO2	Homo sapiens	Residual Activity	=	16	%	23398362
NPT3272	Individual Protein	Tyrosine-protein kinase TXK	Homo sapiens	Residual Activity	=	5	%	23398362
NPT3422	Individual Protein	Serine/threonine-protein kinase ULK2	Homo sapiens	Residual Activity	=	7	%	23398362
NPT1344	Individual Protein	Serine/threonine-protein kinase EEF2K	Homo sapiens	Residual Activity	=	115	%	23398362
NPT3454	Individual Protein	PAS domain-containing serine/threonine-protein kinase	Homo sapiens	Residual Activity	=	14	%	23398362
NPT881	Individual Protein	Protein kinase C delta	Homo sapiens	Residual Activity	=	18	%	23398362
NPT3204	Individual Protein	Tyrosine-protein kinase FRK	Homo sapiens	Residual Activity	=	25	%	23398362
NPT3107	Individual Protein	Rho-associated protein kinase 2	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3370	Individual Protein	Tyrosine-protein kinase receptor RET	Homo sapiens	Residual Activity	=	2	%	23398362
NPT1614	Individual Protein	MAP kinase p38 delta	Homo sapiens	Residual Activity	=	10	%	23398362
NPT3426	Individual Protein	Serine/threonine-protein kinase TAO2	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3422	Individual Protein	Serine/threonine-protein kinase ULK2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Residual Activity	=	90	%	23398362
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Residual Activity	=	70	%	23398362
NPT3454	Individual Protein	PAS domain-containing serine/threonine-protein kinase	Homo sapiens	Residual Activity	=	4	%	23398362
NPT3020	Individual Protein	Platelet-derived growth factor receptor alpha	Homo sapiens	Residual Activity	=	32	%	23398362
NPT881	Individual Protein	Protein kinase C delta	Homo sapiens	Residual Activity	=	3	%	23398362
NPT761	Individual Protein	Protein kinase C epsilon	Homo sapiens	Residual Activity	=	51	%	23398362
NPT3204	Individual Protein	Tyrosine-protein kinase FRK	Homo sapiens	Residual Activity	=	6	%	23398362
NPT3370	Individual Protein	Tyrosine-protein kinase receptor RET	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1448	Individual Protein	Serine/threonine-protein kinase Sgk1	Homo sapiens	Residual Activity	=	4	%	23398362
NPT1448	Individual Protein	Serine/threonine-protein kinase Sgk1	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3427	Individual Protein	Serine/threonine-protein kinase TAO3	Homo sapiens	Residual Activity	=	10	%	23398362
NPT3427	Individual Protein	Serine/threonine-protein kinase TAO3	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3382	Individual Protein	Serine/threonine-protein kinase ULK3	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3382	Individual Protein	Serine/threonine-protein kinase ULK3	Homo sapiens	Residual Activity	=	1	%	23398362
NPT4095	Protein Complex	Mammalian target of Rapamycin (mTORC1)	Homo sapiens	Residual Activity	=	89	%	23398362
NPT3020	Individual Protein	Platelet-derived growth factor receptor alpha	Homo sapiens	Residual Activity	=	8	%	23398362
NPT761	Individual Protein	Protein kinase C epsilon	Homo sapiens	Residual Activity	=	10	%	23398362
NPT3223	Individual Protein	Phosphorylase kinase gamma subunit 2	Homo sapiens	Residual Activity	=	0	%	23398362
NPT3223	Individual Protein	Phosphorylase kinase gamma subunit 2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3390	Individual Protein	Macrophage-stimulating protein receptor	Homo sapiens	Residual Activity	=	33	%	23398362
NPT3390	Individual Protein	Macrophage-stimulating protein receptor	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3456	Individual Protein	Serine/threonine-protein kinase Sgk2	Homo sapiens	Residual Activity	=	7	%	23398362
NPT3417	Individual Protein	Serine/threonine-protein kinase TBK1	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT1715	Individual Protein	Serine/threonine-protein kinase VRK2	Homo sapiens	Residual Activity	=	100	%	23398362
NPT4095	Protein Complex	Mammalian target of Rapamycin (mTORC1)	Homo sapiens	Residual Activity	=	79	%	23398362
NPT1611	Individual Protein	Ribosomal protein S6 kinase 1	Homo sapiens	Residual Activity	=	6	%	23398362
NPT2575	Individual Protein	Platelet-derived growth factor receptor beta	Homo sapiens	Residual Activity	=	46	%	23398362
NPT2575	Individual Protein	Platelet-derived growth factor receptor beta	Homo sapiens	Residual Activity	=	8	%	23398362
NPT3455	Individual Protein	Protein kinase C zeta	Homo sapiens	Residual Activity	=	52	%	23398362
NPT3455	Individual Protein	Protein kinase C zeta	Homo sapiens	Residual Activity	=	8	%	23398362
NPT1265	Individual Protein	Serine/threonine-protein kinase PIM1	Homo sapiens	Residual Activity	=	10	%	23398362
NPT3373	Individual Protein	Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens	Residual Activity	=	21	%	23398362
NPT3456	Individual Protein	Serine/threonine-protein kinase Sgk2	Homo sapiens	Residual Activity	=	1	%	23398362
NPT3418	Individual Protein	Serine/threonine-protein kinase Sgk3	Homo sapiens	Residual Activity	=	47	%	23398362
NPT3417	Individual Protein	Serine/threonine-protein kinase TBK1	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3353	Individual Protein	TGF-beta receptor type I	Homo sapiens	Residual Activity	=	49	%	23398362
NPT1715	Individual Protein	Serine/threonine-protein kinase VRK2	Homo sapiens	Residual Activity	=	101	%	23398362
NPT1611	Individual Protein	Ribosomal protein S6 kinase 1	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1699	Individual Protein	3-phosphoinositide dependent protein kinase-1	Homo sapiens	Residual Activity	=	-1	%	23398362
NPT3124	Individual Protein	Protein kinase C eta	Homo sapiens	Residual Activity	=	36	%	23398362
NPT1265	Individual Protein	Serine/threonine-protein kinase PIM1	Homo sapiens	Residual Activity	=	1	%	23398362
NPT1700	Individual Protein	Serine/threonine-protein kinase PIM2	Homo sapiens	Residual Activity	=	2	%	23398362
NPT3373	Individual Protein	Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens	Residual Activity	=	3	%	23398362
NPT3277	Individual Protein	Tyrosine-protein kinase receptor TYRO3	Homo sapiens	Residual Activity	=	6	%	23398362
NPT3418	Individual Protein	Serine/threonine-protein kinase Sgk3	Homo sapiens	Residual Activity	=	13	%	23398362
NPT3353	Individual Protein	TGF-beta receptor type I	Homo sapiens	Residual Activity	=	8	%	23398362
NPT4096	Individual Protein	Serine/threonine-protein kinase WNK2	Homo sapiens	Residual Activity	=	63	%	23398362
NPT4096	Individual Protein	Serine/threonine-protein kinase WNK2	Homo sapiens	Residual Activity	=	12	%	23398362
NPT3464	Individual Protein	Myelin transcription factor 1	Homo sapiens	Activity	<	5	%	22770610

Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC94428 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	293
0.1-0.2	1472
0.2-0.3	6824
0.3-0.4	14120
0.4-0.5	5264
0.5-0.6	1878
0.6-0.7	994
0.7-0.8	40
0.8-0.85	1
0.85-0.9	2
0.9-0.95	0
0.95-1	1

Similarity Score	Similarity Level	Natural Product ID
1.0	High Similarity	NPC263937
0.8539	High Similarity	NPC313884
0.8539	High Similarity	NPC98371
0.8276	Intermediate Similarity	NPC107836
0.7724	Intermediate Similarity	NPC1203
0.771	Intermediate Similarity	NPC195314
0.7708	Intermediate Similarity	NPC279589
0.7677	Intermediate Similarity	NPC45048
0.7637	Intermediate Similarity	NPC472207
0.7522	Intermediate Similarity	NPC31700
0.7521	Intermediate Similarity	NPC473565
0.7433	Intermediate Similarity	NPC472842
0.7401	Intermediate Similarity	NPC294620
0.7339	Intermediate Similarity	NPC41318
0.7339	Intermediate Similarity	NPC469312
0.7325	Intermediate Similarity	NPC475778
0.7288	Intermediate Similarity	NPC183426
0.7244	Intermediate Similarity	NPC314648
0.7238	Intermediate Similarity	NPC132329
0.7229	Intermediate Similarity	NPC473441
0.7229	Intermediate Similarity	NPC131273
0.7222	Intermediate Similarity	NPC472846
0.7211	Intermediate Similarity	NPC472843
0.7207	Intermediate Similarity	NPC102008
0.7162	Intermediate Similarity	NPC234999
0.7131	Intermediate Similarity	NPC471583
0.7131	Intermediate Similarity	NPC471782
0.7118	Intermediate Similarity	NPC469743
0.7105	Intermediate Similarity	NPC315545
0.7105	Intermediate Similarity	NPC314297
0.7104	Intermediate Similarity	NPC473178
0.709	Intermediate Similarity	NPC278540
0.7087	Intermediate Similarity	NPC314834
0.7085	Intermediate Similarity	NPC160898
0.7085	Intermediate Similarity	NPC311451
0.7083	Intermediate Similarity	NPC472844
0.7061	Intermediate Similarity	NPC315638
0.7061	Intermediate Similarity	NPC313796
0.7061	Intermediate Similarity	NPC313345
0.7061	Intermediate Similarity	NPC314855
0.7059	Intermediate Similarity	NPC476818
0.7022	Intermediate Similarity	NPC32200
0.7018	Intermediate Similarity	NPC62510
0.7004	Intermediate Similarity	NPC193761
0.6978	Remote Similarity	NPC149708
0.6972	Remote Similarity	NPC472119
0.6971	Remote Similarity	NPC33949
0.6942	Remote Similarity	NPC473806
0.6942	Remote Similarity	NPC471634
0.6937	Remote Similarity	NPC129909
0.6933	Remote Similarity	NPC471506
0.693	Remote Similarity	NPC56618
0.693	Remote Similarity	NPC162730
0.6923	Remote Similarity	NPC61435
0.6923	Remote Similarity	NPC74562
0.6923	Remote Similarity	NPC316181
0.6923	Remote Similarity	NPC151781
0.6913	Remote Similarity	NPC277350
0.6911	Remote Similarity	NPC285343
0.6895	Remote Similarity	NPC470003
0.6888	Remote Similarity	NPC79107
0.6888	Remote Similarity	NPC227908
0.6888	Remote Similarity	NPC475424
0.6878	Remote Similarity	NPC473177
0.6867	Remote Similarity	NPC94541
0.6867	Remote Similarity	NPC470843
0.6863	Remote Similarity	NPC478080
0.6856	Remote Similarity	NPC474116
0.6844	Remote Similarity	NPC289299
0.6844	Remote Similarity	NPC57994
0.6842	Remote Similarity	NPC472845
0.6842	Remote Similarity	NPC214428
0.6842	Remote Similarity	NPC28945
0.6835	Remote Similarity	NPC312645
0.6833	Remote Similarity	NPC90415
0.6828	Remote Similarity	NPC212213
0.6828	Remote Similarity	NPC474916
0.6822	Remote Similarity	NPC478157
0.682	Remote Similarity	NPC132642
0.682	Remote Similarity	NPC128115
0.6818	Remote Similarity	NPC203635
0.6811	Remote Similarity	NPC14812
0.681	Remote Similarity	NPC477065
0.6805	Remote Similarity	NPC237901
0.6805	Remote Similarity	NPC195788
0.6804	Remote Similarity	NPC314394
0.6802	Remote Similarity	NPC472323
0.68	Remote Similarity	NPC192306
0.679	Remote Similarity	NPC476492
0.6789	Remote Similarity	NPC220852
0.6786	Remote Similarity	NPC472097
0.6783	Remote Similarity	NPC57398
0.6777	Remote Similarity	NPC245756
0.6777	Remote Similarity	NPC235885
0.6773	Remote Similarity	NPC243058
0.676	Remote Similarity	NPC81175
0.6753	Remote Similarity	NPC477135
0.6752	Remote Similarity	NPC469589
0.675	Remote Similarity	NPC61813
0.6747	Remote Similarity	NPC474183
0.6738	Remote Similarity	NPC244741
0.6737	Remote Similarity	NPC244856
0.6737	Remote Similarity	NPC472098
0.6736	Remote Similarity	NPC229893
0.6725	Remote Similarity	NPC192674
0.6723	Remote Similarity	NPC469928
0.6722	Remote Similarity	NPC2395
0.6721	Remote Similarity	NPC323752
0.6713	Remote Similarity	NPC158129
0.6713	Remote Similarity	NPC126492
0.6712	Remote Similarity	NPC133261
0.6712	Remote Similarity	NPC473189
0.671	Remote Similarity	NPC476073
0.6709	Remote Similarity	NPC89508
0.6708	Remote Similarity	NPC475476
0.6708	Remote Similarity	NPC242446
0.6707	Remote Similarity	NPC282033
0.6704	Remote Similarity	NPC260909
0.6697	Remote Similarity	NPC472104
0.6697	Remote Similarity	NPC472444
0.6696	Remote Similarity	NPC181502
0.6696	Remote Similarity	NPC85066
0.6696	Remote Similarity	NPC46413
0.6695	Remote Similarity	NPC475841
0.6695	Remote Similarity	NPC474145
0.6682	Remote Similarity	NPC311858
0.6681	Remote Similarity	NPC239954
0.6681	Remote Similarity	NPC97388
0.6681	Remote Similarity	NPC473650
0.6681	Remote Similarity	NPC474412
0.6681	Remote Similarity	NPC160527
0.668	Remote Similarity	NPC86078
0.6667	Remote Similarity	NPC471564
0.6667	Remote Similarity	NPC75634
0.6667	Remote Similarity	NPC471303
0.6667	Remote Similarity	NPC53344
0.6667	Remote Similarity	NPC211997
0.6654	Remote Similarity	NPC476493
0.6653	Remote Similarity	NPC323198
0.6653	Remote Similarity	NPC330009
0.6653	Remote Similarity	NPC203614
0.6653	Remote Similarity	NPC204491
0.6653	Remote Similarity	NPC475258
0.6639	Remote Similarity	NPC306644
0.6639	Remote Similarity	NPC141428
0.6639	Remote Similarity	NPC229348
0.6639	Remote Similarity	NPC236424
0.6639	Remote Similarity	NPC473547
0.6638	Remote Similarity	NPC314957
0.6636	Remote Similarity	NPC256268
0.6636	Remote Similarity	NPC472443
0.6629	Remote Similarity	NPC227824
0.6627	Remote Similarity	NPC477066
0.6626	Remote Similarity	NPC191382
0.6626	Remote Similarity	NPC56109
0.6626	Remote Similarity	NPC155444
0.6625	Remote Similarity	NPC96131
0.6625	Remote Similarity	NPC472285
0.6624	Remote Similarity	NPC82370
0.6624	Remote Similarity	NPC250129
0.6623	Remote Similarity	NPC79129
0.6623	Remote Similarity	NPC249150
0.6623	Remote Similarity	NPC49196
0.6623	Remote Similarity	NPC81654
0.6623	Remote Similarity	NPC195461
0.6623	Remote Similarity	NPC313985
0.6622	Remote Similarity	NPC19679
0.6621	Remote Similarity	NPC472122
0.6621	Remote Similarity	NPC24594
0.6621	Remote Similarity	NPC134586
0.6614	Remote Similarity	NPC478029
0.6614	Remote Similarity	NPC470784
0.6614	Remote Similarity	NPC470785
0.6612	Remote Similarity	NPC909
0.6612	Remote Similarity	NPC112547
0.6612	Remote Similarity	NPC475338
0.6612	Remote Similarity	NPC24370
0.6612	Remote Similarity	NPC319232
0.6611	Remote Similarity	NPC274842
0.661	Remote Similarity	NPC284102
0.661	Remote Similarity	NPC478158
0.6609	Remote Similarity	NPC168911
0.6609	Remote Similarity	NPC165599
0.6608	Remote Similarity	NPC55493
0.6606	Remote Similarity	NPC15840
0.6601	Remote Similarity	NPC478081
0.66	Remote Similarity	NPC478028
0.6598	Remote Similarity	NPC473310
0.6597	Remote Similarity	NPC151976
0.6597	Remote Similarity	NPC94157
0.6597	Remote Similarity	NPC87856
0.6594	Remote Similarity	NPC205403
0.6593	Remote Similarity	NPC329858
0.6591	Remote Similarity	NPC219848
0.659	Remote Similarity	NPC472436
0.659	Remote Similarity	NPC478006
0.6589	Remote Similarity	NPC153400
0.6585	Remote Similarity	NPC476491
0.6585	Remote Similarity	NPC473185
0.6585	Remote Similarity	NPC57690

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC94428 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	194
0.1-0.2	611
0.2-0.3	928
0.3-0.4	1806
0.4-0.5	3070
0.5-0.6	2010
0.6-0.7	507
0.7-0.8	26
0.8-0.85	2
0.85-0.9	3
0.9-0.95	4
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
0.9452	High Similarity	NPD7769	Phase 3
0.9279	High Similarity	NPD6455	Phase 3
0.9234	High Similarity	NPD6717	Clinical (unspecified phase)
0.9005	High Similarity	NPD7770	Phase 3
0.8545	High Similarity	NPD6978	Phase 2
0.8545	High Similarity	NPD6977	Clinical (unspecified phase)
0.8539	High Similarity	NPD6976	Clinical (unspecified phase)
0.8348	Intermediate Similarity	NPD7921	Approved
0.8045	Intermediate Similarity	NPD7073	Clinical (unspecified phase)
0.7621	Intermediate Similarity	NPD6456	Discontinued
0.7366	Intermediate Similarity	NPD4901	Clinical (unspecified phase)
0.7342	Intermediate Similarity	NPD7688	Phase 1
0.7339	Intermediate Similarity	NPD6995	Phase 1
0.7336	Intermediate Similarity	NPD7181	Phase 3
0.7289	Intermediate Similarity	NPD6732	Clinical (unspecified phase)
0.725	Intermediate Similarity	NPD6142	Phase 3
0.7212	Intermediate Similarity	NPD7001	Phase 3
0.7207	Intermediate Similarity	NPD7778	Approved
0.7207	Intermediate Similarity	NPD53	Approved
0.7207	Intermediate Similarity	NPD7777	Approved
0.7185	Intermediate Similarity	NPD7767	Approved
0.7162	Intermediate Similarity	NPD4900	Clinical (unspecified phase)
0.7156	Intermediate Similarity	NPD5721	Clinical (unspecified phase)
0.715	Intermediate Similarity	NPD6452	Discontinued
0.7126	Intermediate Similarity	NPD5488	Discontinued
0.7095	Intermediate Similarity	NPD3746	Discontinued
0.7076	Intermediate Similarity	NPD5507	Approved
0.7076	Intermediate Similarity	NPD5506	Approved
0.7073	Intermediate Similarity	NPD5821	Approved
0.7048	Intermediate Similarity	NPD2920	Discontinued
0.7009	Intermediate Similarity	NPD5003	Discontinued
0.7008	Intermediate Similarity	NPD7772	Phase 3
0.7	Intermediate Similarity	NPD7397	Approved
0.7	Intermediate Similarity	NPD7398	Approved
0.7	Intermediate Similarity	NPD6965	Clinical (unspecified phase)
0.6978	Remote Similarity	NPD4987	Clinical (unspecified phase)
0.697	Remote Similarity	NPD5834	Phase 3
0.697	Remote Similarity	NPD5835	Phase 3
0.6966	Remote Similarity	NPD4897	Phase 2
0.6947	Remote Similarity	NPD6661	Clinical (unspecified phase)
0.6943	Remote Similarity	NPD6987	Phase 1
0.6937	Remote Similarity	NPD3785	Clinical (unspecified phase)
0.6936	Remote Similarity	NPD6733	Discontinued
0.6913	Remote Similarity	NPD5530	Phase 1
0.6895	Remote Similarity	NPD7417	Discontinued
0.6892	Remote Similarity	NPD2564	Approved
0.6892	Remote Similarity	NPD2565	Phase 2
0.6878	Remote Similarity	NPD4948	Discontinued
0.6878	Remote Similarity	NPD7878	Phase 2
0.6872	Remote Similarity	NPD7000	Clinical (unspecified phase)
0.6872	Remote Similarity	NPD6999	Discontinued
0.687	Remote Similarity	NPD5425	Phase 1
0.686	Remote Similarity	NPD7268	Clinical (unspecified phase)
0.6858	Remote Similarity	NPD6206	Phase 1
0.6855	Remote Similarity	NPD8017	Clinical (unspecified phase)
0.6855	Remote Similarity	NPD8016	Phase 3
0.6847	Remote Similarity	NPD4334	Discontinued
0.6846	Remote Similarity	NPD7271	Approved
0.6844	Remote Similarity	NPD4602	Approved
0.6831	Remote Similarity	NPD7710	Clinical (unspecified phase)
0.6828	Remote Similarity	NPD7889	Clinical (unspecified phase)
0.6828	Remote Similarity	NPD6261	Phase 3
0.6815	Remote Similarity	NPD4938	Phase 2
0.681	Remote Similarity	NPD7453	Approved
0.681	Remote Similarity	NPD7452	Approved
0.6805	Remote Similarity	NPD8465	Approved
0.6805	Remote Similarity	NPD8429	Approved
0.6805	Remote Similarity	NPD8466	Approved
0.6805	Remote Similarity	NPD8428	Approved
0.6805	Remote Similarity	NPD8427	Approved
0.6805	Remote Similarity	NPD8467	Approved
0.6802	Remote Similarity	NPD5891	Approved
0.6798	Remote Similarity	NPD6249	Phase 2
0.6798	Remote Similarity	NPD6248	Phase 2
0.679	Remote Similarity	NPD7730	Approved
0.679	Remote Similarity	NPD7731	Approved
0.6789	Remote Similarity	NPD7950	Approved
0.6789	Remote Similarity	NPD7790	Approved
0.6789	Remote Similarity	NPD7953	Approved
0.6789	Remote Similarity	NPD7789	Approved
0.6789	Remote Similarity	NPD7791	Approved
0.6789	Remote Similarity	NPD7952	Approved
0.6789	Remote Similarity	NPD7951	Approved
0.6781	Remote Similarity	NPD7665	Phase 2
0.6781	Remote Similarity	NPD7666	Phase 3
0.6776	Remote Similarity	NPD5021	Discontinued
0.677	Remote Similarity	NPD4427	Phase 2
0.6765	Remote Similarity	NPD8000	Clinical (unspecified phase)
0.6758	Remote Similarity	NPD5899	Approved
0.6758	Remote Similarity	NPD5898	Approved
0.6758	Remote Similarity	NPD5897	Approved
0.6753	Remote Similarity	NPD5487	Phase 1
0.6741	Remote Similarity	NPD6281	Approved
0.674	Remote Similarity	NPD6449	Clinical (unspecified phase)
0.6735	Remote Similarity	NPD7824	Approved
0.6725	Remote Similarity	NPD3800	Clinical (unspecified phase)
0.6724	Remote Similarity	NPD5426	Phase 3
0.6712	Remote Similarity	NPD6344	Clinical (unspecified phase)
0.6712	Remote Similarity	NPD6227	Discontinued
0.6704	Remote Similarity	NPD8426	Approved
0.6704	Remote Similarity	NPD8460	Approved
0.6704	Remote Similarity	NPD8459	Approved
0.6704	Remote Similarity	NPD8425	Approved
0.6695	Remote Similarity	NPD7470	Discontinued
0.6682	Remote Similarity	NPD5444	Phase 1
0.6681	Remote Similarity	NPD4886	Phase 2
0.6681	Remote Similarity	NPD4315	Phase 2
0.668	Remote Similarity	NPD7776	Approved
0.6667	Remote Similarity	NPD4852	Phase 2
0.6667	Remote Similarity	NPD7589	Clinical (unspecified phase)
0.6667	Remote Similarity	NPD6716	Phase 1
0.6667	Remote Similarity	NPD8093	Discontinued
0.6667	Remote Similarity	NPD8322	Phase 2
0.6653	Remote Similarity	NPD4414	Discontinued
0.6653	Remote Similarity	NPD5040	Clinical (unspecified phase)
0.6652	Remote Similarity	NPD6141	Clinical (unspecified phase)
0.6652	Remote Similarity	NPD7712	Clinical (unspecified phase)
0.6652	Remote Similarity	NPD6138	Clinical (unspecified phase)
0.6652	Remote Similarity	NPD3390	Phase 2
0.6651	Remote Similarity	NPD2882	Phase 1
0.6637	Remote Similarity	NPD7424	Clinical (unspecified phase)
0.6627	Remote Similarity	NPD6970	Phase 2
0.6627	Remote Similarity	NPD7576	Discontinued
0.6626	Remote Similarity	NPD7781	Approved
0.6626	Remote Similarity	NPD7780	Approved
0.6623	Remote Similarity	NPD4600	Approved
0.6623	Remote Similarity	NPD4601	Approved
0.6623	Remote Similarity	NPD7944	Discontinued
0.6621	Remote Similarity	NPD6375	Clinical (unspecified phase)
0.6613	Remote Similarity	NPD7797	Approved
0.6613	Remote Similarity	NPD7796	Approved
0.6601	Remote Similarity	NPD7857	Phase 3
0.6601	Remote Similarity	NPD7856	Phase 2
0.6599	Remote Similarity	NPD5801	Clinical (unspecified phase)
0.6596	Remote Similarity	NPD7222	Phase 2
0.659	Remote Similarity	NPD1325	Approved
0.659	Remote Similarity	NPD1326	Approved
0.6586	Remote Similarity	NPD4373	Phase 2
0.6581	Remote Similarity	NPD5901	Discontinued
0.6581	Remote Similarity	NPD7103	Approved
0.658	Remote Similarity	NPD7621	Clinical (unspecified phase)
0.6579	Remote Similarity	NPD8364	Approved
0.6579	Remote Similarity	NPD3403	Clinical (unspecified phase)
0.6579	Remote Similarity	NPD8363	Approved
0.6574	Remote Similarity	NPD4554	Clinical (unspecified phase)
0.6564	Remote Similarity	NPD5912	Clinical (unspecified phase)
0.6564	Remote Similarity	NPD5913	Phase 3
0.6556	Remote Similarity	NPD8325	Phase 3
0.6556	Remote Similarity	NPD8406	Clinical (unspecified phase)
0.6556	Remote Similarity	NPD8327	Clinical (unspecified phase)
0.6556	Remote Similarity	NPD8326	Phase 3
0.6549	Remote Similarity	NPD7197	Approved
0.6538	Remote Similarity	NPD3777	Phase 3
0.6537	Remote Similarity	NPD4397	Phase 1
0.6535	Remote Similarity	NPD7860	Clinical (unspecified phase)
0.6532	Remote Similarity	NPD8464	Clinical (unspecified phase)
0.6531	Remote Similarity	NPD7716	Approved
0.6531	Remote Similarity	NPD7717	Approved
0.653	Remote Similarity	NPD8365	Clinical (unspecified phase)
0.6527	Remote Similarity	NPD8096	Phase 3
0.6527	Remote Similarity	NPD8097	Phase 3
0.6523	Remote Similarity	NPD5807	Phase 2
0.6522	Remote Similarity	NPD7818	Clinical (unspecified phase)
0.6516	Remote Similarity	NPD7726	Phase 1
0.6511	Remote Similarity	NPD8098	Approved
0.6506	Remote Similarity	NPD6962	Phase 2
0.6502	Remote Similarity	NPD7867	Phase 1
0.65	Remote Similarity	NPD7276	Approved
0.65	Remote Similarity	NPD7277	Approved
0.65	Remote Similarity	NPD6492	Phase 2
0.6498	Remote Similarity	NPD8358	Approved
0.6496	Remote Similarity	NPD6975	Discontinued
0.6493	Remote Similarity	NPD6158	Phase 2
0.6493	Remote Similarity	NPD6476	Clinical (unspecified phase)
0.6491	Remote Similarity	NPD6630	Clinical (unspecified phase)
0.6486	Remote Similarity	NPD5398	Clinical (unspecified phase)
0.6483	Remote Similarity	NPD7958	Clinical (unspecified phase)
0.6483	Remote Similarity	NPD4862	Clinical (unspecified phase)
0.6483	Remote Similarity	NPD7957	Phase 1
0.6478	Remote Similarity	NPD4418	Discontinued
0.6473	Remote Similarity	NPD5596	Phase 2
0.6471	Remote Similarity	NPD4520	Approved
0.6468	Remote Similarity	NPD4638	Approved
0.6468	Remote Similarity	NPD4639	Approved
0.6468	Remote Similarity	NPD4640	Approved
0.6466	Remote Similarity	NPD7946	Pre-registration
0.6466	Remote Similarity	NPD4952	Phase 3
0.6461	Remote Similarity	NPD7395	Discontinued
0.6457	Remote Similarity	NPD4561	Discontinued
0.6457	Remote Similarity	NPD7025	Clinical (unspecified phase)
0.6456	Remote Similarity	NPD5429	Discontinued
0.6452	Remote Similarity	NPD6292	Clinical (unspecified phase)
0.6449	Remote Similarity	NPD4326	Phase 2
0.6447	Remote Similarity	NPD4499	Approved
0.6446	Remote Similarity	NPD7218	Clinical (unspecified phase)
0.6441	Remote Similarity	NPD8489	Phase 1
0.6437	Remote Similarity	NPD3925	Approved
0.6432	Remote Similarity	NPD2383	Phase 1
0.6429	Remote Similarity	NPD8329	Phase 3
0.6429	Remote Similarity	NPD4204	Approved

Structure

CID94428 OpenBabel06191715432D 35 42 0 0 1 0 0 0 0 0999 V2000 -1.3401 -0.1115 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.8148 -2.3170 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3698 2.0790 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.6370 0.2264 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3696 1.3157 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.3068 -0.2382 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7093 2.4606 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.3998 0.7446 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.7090 0.9344 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.7394 -0.1845 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.3211 -0.1144 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.1618 2.5903 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0482 2.0793 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.8323 0.7983 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5949 2.0798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0480 1.3160 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5021 0.3337 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.3873 0.3871 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -1.5951 1.3165 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.2734 2.0796 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.9343 2.4611 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.2735 1.3163 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.9346 0.9350 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.0928 3.2073 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.6336 -0.9428 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.5476 0.0001 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -0.1463 -0.3079 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 -1.8514 3.2871 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 0.3874 0.9347 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -0.9347 0.3874 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -0.5572 3.8020 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -1.4270 -0.8381 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.1598 -1.0474 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.3275 -1.6822 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 -0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 26 1 0 0 0 0 2 34 1 0 0 0 0 3 5 2 0 0 0 0 3 7 1 0 0 0 0 4 6 2 0 0 0 0 4 8 1 0 0 0 0 5 9 1 0 0 0 0 6 10 1 0 0 0 0 7 13 2 0 0 0 0 8 14 2 0 0 0 0 9 16 2 0 0 0 0 10 17 2 0 0 0 0 11 27 1 0 0 0 0 12 15 1 0 0 0 0 12 28 1 0 0 0 0 13 16 1 0 0 0 0 13 20 1 0 0 0 0 14 17 1 0 0 0 0 14 19 1 0 0 0 0 15 19 2 0 0 0 0 15 21 1 0 0 0 0 16 29 1 0 0 0 0 17 30 1 0 0 0 0 18 11 1 1 0 0 0 18 29 1 0 0 0 0 18 35 1 0 0 0 0 19 23 1 0 0 0 0 20 21 2 0 0 0 0 20 22 1 0 0 0 0 21 24 1 0 0 0 0 22 23 2 0 0 0 0 22 29 1 0 0 0 0 23 30 1 0 0 0 0 24 28 2 0 0 0 0 24 31 1 0 0 0 0 25 27 1 0 0 0 0 25 32 2 0 0 0 0 25 34 1 0 0 0 0 26 27 1 1 0 0 0 26 30 1 0 0 0 0 26 35 1 0 0 0 0 27 33 1 1 0 0 0 M END $$$$

External Identifiers

PubChem CID	3035817
ChEMBL	CHEMBL281948
ZINC

Physicochemical Properties

Molecular Weight:	467.15
ALogP:	-1.2404
MLogP:	3.55
XLogP:	3.637
# Rotatable Bonds:	6
Polar Surface Area:	98.21
# H-Bond Aceptor:	8
# H-Bond Donor:	2
# Rings:	8
# Heavy Atoms:	35

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