Natural Product: NPC109083

Natural Product ID:  NPC109083
Common Name:   Curcumin
IUPAC Name:   (1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one
Synonyms:   CI-75300; Curcumin; Diferuloylmethane; E100; Natural Yellow 3
Molecular Formula:   C21H20O6
Standard InCHIKey:  ZIUSSTSXXLLKKK-KOBPDPAPSA-N
Standard InCHI:  InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,22,24-25H,1-2H3/b7-3+,8-4+,16-13-
Canonical SMILES:  COc1cc(/C=C/C(=C/C(=O)/C=C/c2ccc(c(c2)OC)O)/O)ccc1O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO23911 Alpinia officinarum Species Zingiberaceae Eukaryota TCM_Taiwan*
NPO24124 Curcuma longa Species Zingiberaceae Eukaryota TCM_Taiwan*
NPO25209 Curcuma aromatica Species Zingiberaceae Eukaryota TCM_Taiwan*
NPO2618 Curcuma wenyujin Species Zingiberaceae Eukaryota TCM_Taiwan*
NPO31101 Acarus calamus Species Acaridae Eukaryota TCM_Taiwan*
NPO7929 Curcuma zedoaria Species Zingiberaceae Eukaryota TCM_Taiwan*
NPO33283 zedoariae rhizoma NA NA NA PMID[9871681]
NPO24124 Curcuma longa Species Zingiberaceae Eukaryota PMID[12350137]
NPO33471 Zingiber spectabile Species Zingiberaceae Eukaryota Rhizomes PMID[22546674]
NPO24124 Curcuma longa Species Zingiberaceae Eukaryota rhizome PMID[12617587]
NPO33577 Pyxidicoccus fallax Species Myxococcaceae Bacteria PMID[25686392]
NPO3532 Tridentata marginata NA NA NA UNPD*
NPO7308 Fraxinus quadrangulata Species Oleaceae Eukaryota UNPD*
NPO3251 Jacobaea maritima Species Asteraceae Eukaryota UNPD*
NPO25160 Goniothalamus borneensis Species Annonaceae Eukaryota UNPD*
NPO9241 Adiantum capillus-veneris Species Pteridaceae Eukaryota UNPD*
NPO1505 Amomum tsao-ko Species Zingiberaceae Eukaryota TCMSP*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT12 Individual Protein Human immunodeficiency virus type 1 integrase Human immunodeficiency virus 1 IC50 = 150000 nM 9301668
NPT12 Individual Protein Human immunodeficiency virus type 1 integrase Human immunodeficiency virus 1 IC50 = 140000 nM 9301668
NPT12 Individual Protein Human immunodeficiency virus type 1 integrase Human immunodeficiency virus 1 IC50 = 30000 nM 9767632
NPT25 Cell Line MT4 Homo sapiens CC50 = 7400 nM 9767632
NPT91 Cell Line KB Homo sapiens CC50 = 16000 nM 9767632
NPT319 Cell Line B16 Mus musculus Inhibition = 87 % 14643343
NPT12 Individual Protein Human immunodeficiency virus type 1 integrase Human immunodeficiency virus 1 IC50 = 57500 nM 10969990
NPT681 Cell Line PC-12 Rattus norvegicus ED50 = 7.1 ug/ml 11549465
NPT744 Cell Line IMR-32 Homo sapiens ED50 = 7.4 ug/ml 11549465
NPT12 Individual Protein Human immunodeficiency virus type 1 integrase Human immunodeficiency virus 1 IC50 = 30199.52 nM 11831895
NPT32 Organism Mus musculus Mus musculus Inhibition = 71.2 % 9871681
NPT32 Organism Mus musculus Mus musculus Inhibition = 63.4 % 9871681
NPT29 Organism Rattus norvegicus Rattus norvegicus Inhibition = -44.3 % 9871681
NPT32 Organism Mus musculus Mus musculus Inhibition = 98.8 % 9871681
NPT681 Cell Line PC-12 Rattus norvegicus ED50 = 17.1 nM 14980683
NPT744 Cell Line IMR-32 Homo sapiens ED50 = 23.9 nM 14980683
NPT737 Cell Line HUVEC Homo sapiens IC50 = 10.84 ug/ml 15993583
NPT324 Individual Protein Cyclooxygenase-1 Ovis aries Inhibition = 80.5 % 15780608
NPT325 Individual Protein Cyclooxygenase-2 Ovis aries Inhibition = 35 % 15780608
NPT4243 Individual Protein Cyclooxygenase-2 Rattus norvegicus Inhibition = 61.4 % 15780608
NPT31 Individual Protein Cyclooxygenase-2 Homo sapiens IC50 = 11060 nM 15780608
NPT29 Organism Rattus norvegicus Rattus norvegicus Inhibition = 80 % 15878268
NPT858 Cell Line LNCaP Homo sapiens IC50 = 3800 nM 16789753
NPT306 Cell Line PC-3 Homo sapiens IC50 = 7700 nM 16789753
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Ki = 0.208 nM 17004725
NPT466 Cell Line U-937 Homo sapiens Activity = 17.5 % 17154519
NPT4244 Individual Protein RmtA Emericella nidulans IC50 = 1100000 nM 17323938
NPT4245 Individual Protein Protein-arginine N-methyltransferase 1 Homo sapiens IC50 = 1070000 nM 17323938
NPT1079 Individual Protein Histone acetyltransferase p300 Homo sapiens IC50 > 400000 nM 17348637
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 24690 nM 17145789
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC90 = 44450 nM 17145789
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 22930 nM 17145789
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC90 = 41270 nM 17145789
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 27450 nM 17145789
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC90 = 49420 nM 17145789
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 29610 nM 17145789
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC90 = 53290 nM 17145789
NPT2 Others Unspecified IC50 = 48000 nM 17145789
NPT2 Others Unspecified Inhibition = 95 % 17145789
NPT2 Others Unspecified EC50 = 10000 nM 17049256
NPT164 Organism Human herpesvirus 4 Human herpesvirus 4 Inhibition = 0 % 17503850
NPT164 Organism Human herpesvirus 4 Human herpesvirus 4 Inhibition = 22.8 % 17503850
NPT164 Organism Human herpesvirus 4 Human herpesvirus 4 Inhibition = 81.7 % 17503850
NPT164 Organism Human herpesvirus 4 Human herpesvirus 4 Inhibition = 100 % 17503850
NPT164 Organism Human herpesvirus 4 Human herpesvirus 4 IC50 = 10.2 nM 17503850
NPT80 Cell Line Raji Homo sapiens Activity = 60 % 17503850
NPT762 Cell Line A-431 Homo sapiens ED50 = 0.75 ug/ml 17643301
NPT1515 Organism SARS coronavirus SARS coronavirus EC50 > 10000 nM 17663539
NPT189 Cell Line Vero Chlorocebus aethiops CC50 > 250000 nM 17663539
NPT2 Others Unspecified IC50 = 40000 nM 17663539
NPT1515 Organism SARS coronavirus SARS coronavirus Inhibition = 25 % 17663539
NPT1515 Organism SARS coronavirus SARS coronavirus Inhibition = 50 % 17663539
NPT164 Organism Human herpesvirus 4 Human herpesvirus 4 Inhibition = 0 % 17316910
NPT164 Organism Human herpesvirus 4 Human herpesvirus 4 Inhibition = 22.8 % 17316910
NPT164 Organism Human herpesvirus 4 Human herpesvirus 4 Inhibition = 81.7 % 17316910
NPT164 Organism Human herpesvirus 4 Human herpesvirus 4 Inhibition = 100 % 17316910
NPT80 Cell Line Raji Homo sapiens Survival = 60 % 17316910
NPT80 Cell Line Raji Homo sapiens Survival > 80 % 17316910
NPT858 Cell Line LNCaP Homo sapiens EC50 = 35000 nM 17383188
NPT164 Organism Human herpesvirus 4 Human herpesvirus 4 IC50 = 345000 nM 17950604
NPT306 Cell Line PC-3 Homo sapiens Activity = 65 % 17973470
NPT306 Cell Line PC-3 Homo sapiens Activity = 90 % 17973470
NPT306 Cell Line PC-3 Homo sapiens IC50 = 12000 nM 17973470
NPT4246 Cell Line LS174T Homo sapiens IC50 = 6500 nM 17973470
NPT783 Cell Line MIA PaCa-2 Homo sapiens IC50 = 9000 nM 17973470
NPT1081 Cell Line BXPC-3 Homo sapiens IC50 = 2900 nM 17973470
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens IC50 = 800 nM 17270435
NPT804 Cell Line HT-22 Mus musculus Activity = 116 % 17270435
NPT137 Cell Line L1210 Mus musculus IC50 = 9000 nM 17768050
NPT404 Cell Line CCRF-CEM Homo sapiens IC50 = 8700 nM 17768050
NPT2 Others Unspecified Inhibition = 0 % 17685651
NPT80 Cell Line Raji Homo sapiens Activity = 70 % 17685651
NPT2 Others Unspecified Inhibition = 22.8 % 17685651
NPT2 Others Unspecified Inhibition = 81.8 % 17685651
NPT2 Others Unspecified Inhibition = 100 % 17685651
NPT111 Cell Line K562 Homo sapiens IC50 = 6810 nM 18076140
NPT2 Others Unspecified IC50 = 17400 nM 18039573
NPT2 Others Unspecified IC70 = 24.6 nM 18039573
NPT83 Cell Line MCF7 Homo sapiens IC50 = 29300 nM 18039573
NPT83 Cell Line MCF7 Homo sapiens IC70 = 51.7 nM 18039573
NPT4247 Cell Line MCF7R Homo sapiens IC50 = 26200 nM 18039573
NPT4247 Cell Line MCF7R Homo sapiens IC70 = 46.2 nM 18039573
NPT2 Others Unspecified Inhibition = 45 % 18042380
NPT2 Others Unspecified EC50 = 10000 nM 18042380
NPT2 Others Unspecified Inhibition = 29 % 17284452
NPT2 Others Unspecified IC50 = 361110 nM 17284452
NPT1892 Cell Line H4 Rattus norvegicus Activity = 59.32 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 228.38 % 18024584
NPT1892 Cell Line H4 Rattus norvegicus Activity = 249.22 % 18024584
NPT570 Individual Protein Arachidonate 5-lipoxygenase Homo sapiens IC50 = 8000 nM 18077363
NPT30 Individual Protein Cyclooxygenase-1 Homo sapiens IC50 = 52000 nM 18077363
NPT3517 Individual Protein Nitric oxide synthase, inducible Homo sapiens IC50 = 6000 nM 18077363
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 3250 nM 18194869
NPT6 Organism Plasmodium falciparum Plasmodium falciparum MIC = 13200 nM 18194869
NPT6 Organism Plasmodium falciparum Plasmodium falciparum MIC = 14400 nM 18194869
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 4210 nM 18194869
NPT91 Cell Line KB Homo sapiens Activity = 89.2 % 18295490
NPT2 Others Unspecified Activity = 93.1 % 18295490
NPT2 Others Unspecified IC50 = 820 nM 18295490
NPT2 Others Unspecified IC50 = 420 nM 18295490
NPT466 Cell Line U-937 Homo sapiens Activity = 25 % 18348515
NPT466 Cell Line U-937 Homo sapiens Activity = 8.5 % 18348515
NPT466 Cell Line U-937 Homo sapiens Activity = 25.3 % 18348515
NPT2 Others Unspecified Activity = 46 % 18434144
NPT521 Cell Line RBL-2H3 Rattus norvegicus Inhibition = 62.6 % 12398545
NPT521 Cell Line RBL-2H3 Rattus norvegicus Inhibition = 14.2 % 12398545
NPT521 Cell Line RBL-2H3 Rattus norvegicus Inhibition = 2 % 12398545
NPT521 Cell Line RBL-2H3 Rattus norvegicus IC50 = 3000 nM 12398545
NPT2 Others Unspecified ED50 = 23.2 nM 11430002
NPT453 Cell Line HT-1080 Homo sapiens ED50 = 23.4 nM 11430002
NPT2 Others Unspecified IC50 = 38300 nM 18678491
NPT2 Others Unspecified IC50 = 4200 nM 18678491
NPT19 Organism Escherichia coli Escherichia coli IZ = 10 mm 18201805
NPT19 Organism Escherichia coli Escherichia coli MIC = 20000000 nM 18201805
NPT20 Organism Candida albicans Candida albicans IZ = 15 mm 18201805
NPT212 Individual Protein Cytochrome P450 2C9 Homo sapiens IC50 = 4300 nM 18249473
NPT109 Individual Protein Cytochrome P450 3A4 Homo sapiens IC50 = 16300 nM 18249473
NPT208 Individual Protein Cytochrome P450 1A2 Homo sapiens IC50 = 40000 nM 18249473
NPT627 Individual Protein Cytochrome P450 2B6 Homo sapiens IC50 = 24500 nM 18249473
NPT110 Individual Protein Cytochrome P450 2D6 Homo sapiens IC50 = 50300 nM 18249473
NPT134 Cell Line SK-BR-3 Homo sapiens IC50 = 2110 nM 19019687
NPT83 Cell Line MCF7 Homo sapiens IC50 = 5580 nM 19019687
NPT2 Others Unspecified Activity = 58.4 % 19179077
NPT2 Others Unspecified EC50 = 7480 nM 19179077
NPT1821 Individual Protein Sortase Staphylococcus aureus IC50 = 13.8 ug/ml 19269184
NPT306 Cell Line PC-3 Homo sapiens IC50 = 19800 nM 19249204
NPT858 Cell Line LNCaP Homo sapiens IC50 = 19600 nM 19249204
NPT83 Cell Line MCF7 Homo sapiens IC50 = 21500 nM 19249204
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 25600 nM 19249204
NPT2 Others Unspecified IC50 = 1020 nM 9599258
NPT30 Individual Protein Cyclooxygenase-1 Homo sapiens IC50 = 8800 nM 16038536
NPT377 Cell Line OVCAR-3 Homo sapiens CD50 = 4.4 ug/ml 9868158
NPT2 Others Unspecified IC50 = 10000 nM 18419109
NPT32 Organism Mus musculus Mus musculus Activity = 45.1 % 19131254
NPT2 Others Unspecified Activity = 0 % 19131254
NPT2 Others Unspecified Activity = 22.8 % 19131254
NPT2 Others Unspecified Activity = 81.7 % 19131254
NPT2 Others Unspecified Activity = 100 % 19131254
NPT2 Others Unspecified IC50 = 331000 nM 19131254
NPT80 Cell Line Raji Homo sapiens Activity = 60 % 19131254
NPT80 Cell Line Raji Homo sapiens Activity > 80 % 19131254
NPT2 Others Unspecified Inhibition = 45 % 19334715
NPT2 Others Unspecified IC50 = 10000 nM 19334715
NPT547 Cell Line BGC-823 Homo sapiens IC50 = 16700 nM 19243951
NPT3887 Cell Line CNE Homo sapiens IC50 = 32800 nM 19243951
NPT91 Cell Line KB Homo sapiens IC50 = 11600 nM 19243951
NPT116 Cell Line HL-60 Homo sapiens IC50 = 35900 nM 19243951
NPT2 Others Unspecified IC50 = 6400 nM 19243951
NPT306 Cell Line PC-3 Homo sapiens IC50 = 15000 nM 19243951
NPT165 Cell Line HeLa Homo sapiens IC50 = 17500 nM 19243951
NPT35 Others n.a. Activity > 64 % 19243951
NPT35 Others n.a. Activity = 92 % 19243951
NPT1719 Cell Line 2008 Homo sapiens Activity > 90 % 19329324
NPT2 Others Unspecified Activity = 60 % 19329324
NPT189 Cell Line Vero Chlorocebus aethiops Activity > 25 % 19329324
NPT189 Cell Line Vero Chlorocebus aethiops Activity = 10 % 19329324
NPT1719 Cell Line 2008 Homo sapiens IC50 = 5000 nM 19329324
NPT2 Others Unspecified IC50 = 17000 nM 19329324
NPT189 Cell Line Vero Chlorocebus aethiops Ratio IC50 = 1.3 19329324
NPT1719 Cell Line 2008 Homo sapiens Ratio IC50 = 3.4 19329324
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 22000 nM 19329324
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens IC50 = 800 nM 18793854
NPT1649 Cell Line MV4-11 Homo sapiens Activity = 15 % 19112019
NPT3701 Individual Protein CpG DNA methylase Spiroplasma monobiae IC50 = 30 nM 19112019
NPT2 Others Unspecified IC50 > 150000 nM 19114310
NPT4248 Individual Protein Histone acetyltransferase KAT5 Homo sapiens IC50 > 200000 nM 19114310
NPT1079 Individual Protein Histone acetyltransferase p300 Homo sapiens IC50 > 40000 nM 19114310
NPT280 Individual Protein Matrix metalloproteinase 9 Homo sapiens IC50 = 8500 nM 19128977
NPT1090 Individual Protein Matrix metalloproteinase 13 Homo sapiens IC50 = 10300 nM 18358729
NPT2 Others Unspecified Kd = 1150 nM 19329310
NPT2 Others Unspecified Kd = 2450 nM 19329310
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 15000 nM 19329310
NPT681 Cell Line PC-12 Rattus norvegicus ED50 = 7 ug/ml 12350137
NPT681 Cell Line PC-12 Rattus norvegicus ED50 = 10 ug/ml 12350137
NPT91 Cell Line KB Homo sapiens IC50 = 5.5 ug/ml 17067159
NPT91 Cell Line KB Homo sapiens IC50 = 3.1 ug/ml 17067159
NPT81 Cell Line A549 Homo sapiens IC50 = 5.2 ug/ml 17067159
NPT23 Individual Protein Integrase Human immunodeficiency virus 1 IC50 = 51.3 ug/ml 16643034
NPT2 Others Unspecified Activity = 96.5 % 16038556
NPT116 Cell Line HL-60 Homo sapiens IC50 = 34220 nM 16038556
NPT65 Cell Line HepG2 Homo sapiens IC50 = 35530 nM 16038556
NPT83 Cell Line MCF7 Homo sapiens IC50 = 10440 nM 16038556
NPT90 Cell Line DU-145 Homo sapiens IC50 = 20600 nM 16038556
NPT397 Cell Line NCI-H460 Homo sapiens IC50 = 27600 nM 16038556
NPT189 Cell Line Vero Chlorocebus aethiops Inhibition = 10 % 18439726
NPT189 Cell Line Vero Chlorocebus aethiops Inhibition = 20 % 18439726
NPT2 Others Unspecified Activity = 0 % 19481937
NPT2 Others Unspecified Activity = 22.8 % 19481937
NPT2 Others Unspecified Activity = 81.7 % 19481937
NPT2 Others Unspecified Activity = 100 % 19481937
NPT2 Others Unspecified IC50 = 341 molar ratio 19481937
NPT80 Cell Line Raji Homo sapiens Activity = 60 % 19481937
NPT80 Cell Line Raji Homo sapiens Activity > 80 % 19481937
NPT1310 Individual Protein Xanthine dehydrogenase Bos taurus Activity = 160 nM/s 19388706
NPT1310 Individual Protein Xanthine dehydrogenase Bos taurus Activity = 150 nM/s 19388706
NPT1310 Individual Protein Xanthine dehydrogenase Bos taurus Inhibition = 60 % 19388706
NPT1310 Individual Protein Xanthine dehydrogenase Bos taurus Inhibition > 20 % 19388706
NPT858 Cell Line LNCaP Homo sapiens IC50 = 8500 nM 19725582
NPT1629 Cell Line CWR22R Homo sapiens IC50 = 18300 nM 19725582
NPT2 Others Unspecified IC50 = 6100 nM 19725582
NPT306 Cell Line PC-3 Homo sapiens IC50 = 16800 nM 19725582
NPT2 Others Unspecified IC50 = 29500 nM 19725582
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 20380 nM 19359068
NPT35 Others n.a. IC50 > 500000 nM 19359068
NPT1 Others Radical scavenging activity IC50 = 109740 nM 19359068
NPT81 Cell Line A549 Homo sapiens IC50 = 13000 nM 19854644
NPT2 Others Unspecified EC50 = 950 nM 19842664
NPT2 Others Unspecified EC50 = 10 nM 19842664
NPT664 Protein Family Histone deacetylase Homo sapiens Activity = 52 % 19520580
NPT664 Protein Family Histone deacetylase Homo sapiens Ki = 539 nM 19520580
NPT664 Protein Family Histone deacetylase Homo sapiens IC50 = 115000 nM 19520580
NPT2 Others Unspecified Activity = 8.9 % 19674905
NPT2 Others Unspecified Activity = 40.3 % 19674905
NPT2 Others Unspecified Activity = 74.5 % 19674905
NPT2 Others Unspecified Activity = 95.8 % 19674905
NPT2 Others Unspecified IC50 = 345000 nM 19674905
NPT80 Cell Line Raji Homo sapiens Activity = 60 % 19674905
NPT1460 Cell Line L929 Mus musculus Inhibition = 25 % 19775895
NPT1460 Cell Line L929 Mus musculus Inhibition = 47 % 19775895
NPT1460 Cell Line L929 Mus musculus Inhibition = 52 % 19775895
NPT1460 Cell Line L929 Mus musculus IC50 = 20000 nM 19775895
NPT737 Cell Line HUVEC Homo sapiens Inhibition = 90 % 19674910
NPT2 Others Unspecified Ratio = 2.1 19646881
NPT19 Organism Escherichia coli Escherichia coli MIC90 = 73.7 ug/ml 19959361
NPT19 Organism Escherichia coli Escherichia coli MIC90 > 500 ug/ml 19959361
NPT1573 Individual Protein Enoyl-[acyl-carrier-protein] reductase Escherichia coli K-12 Ki = 14960 nM 19959361
NPT19 Organism Escherichia coli Escherichia coli Ratio = 7 19959361
NPT579 Cell Line DLD-1 Homo sapiens GI50 = 8000 nM 20060305
NPT881 Individual Protein Protein kinase C delta Homo sapiens EC50 = 10670 nM 20100661
NPT761 Individual Protein Protein kinase C epsilon Homo sapiens EC50 = 8810 nM 20100661
NPT887 Individual Protein Protein kinase C theta Homo sapiens EC50 = 11080 nM 20100661
NPT2752 Individual Protein DNA (cytosine-5)-methyltransferase 1 Homo sapiens Inhibition = 66 % 20006515
NPT3537 Individual Protein DNA (cytosine-5)-methyltransferase 3B Homo sapiens Inhibition = 80 % 20006515
NPT2 Others Unspecified IC50 = 23500 nM 20167482
NPT338 Organism Sindbis virus Sindbis virus EC50 > 10 nM 20034711
NPT335 Organism Human coxsackievirus B4 Human coxsackievirus B4 EC50 > 10 nM 20034711
NPT341 Organism Punta Toro virus Punta Toro virus EC50 > 10 nM 20034711
NPT342 Organism Feline coronavirus Feline coronavirus EC50 > 271 nM 20034711
NPT343 Organism Felid herpesvirus 1 Felid herpesvirus 1 EC50 > 271 nM 20034711
NPT742 Organism Influenza A virus Influenza A virus EC50 > 271 nM 20034711
NPT4249 Organism Influenza B virus Influenza B virus EC50 > 271 nM 20034711
NPT165 Cell Line HeLa Homo sapiens CC50 >= 10 nM 20034711
NPT2192 Cell Line HEL Homo sapiens CC50 >= 10 nM 20034711
NPT2192 Cell Line HEL Homo sapiens CC50 > 2 nM 20034711
NPT189 Cell Line Vero Chlorocebus aethiops CC50 = 54 nM 20034711
NPT616 Cell Line MDCK Canis lupus familiaris CC50 > 92 nM 20034711
NPT24 Organism Human immunodeficiency virus 1 Human immunodeficiency virus 1 IC50 = 37 nM 20034711
NPT3795 Organism Human immunodeficiency virus 2 Human immunodeficiency virus 2 IC50 = 37 nM 20034711
NPT25 Cell Line MT4 Homo sapiens CC50 > 37 nM 20034711
NPT2 Others Unspecified Ratio CC50/IC50 < 1 20034711
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 = 2500 nM 20004045
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 = 4700 nM 20004045
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 = 2900 nM 20004045
NPT841 Organism Leishmania major Leishmania major EC50 = 33000 nM 20004045
NPT842 Organism Leishmania mexicana Leishmania mexicana EC50 = 16000 nM 20004045
NPT71 Cell Line HEK293 Homo sapiens EC50 = 37000 nM 20004045
NPT843 Organism Trypanosoma evansi Trypanosoma evansi EC50 = 2000 nM 20004045
NPT471 Organism Trypanosoma brucei brucei Trypanosoma brucei brucei EC50 = 4800 nM 20004045
NPT3843 Organism Streptococcus viridans Streptococcus viridans MIC = 2470 nM 20034711
NPT19 Organism Escherichia coli Escherichia coli MIC = 1230 nM 20034711
NPT173 Organism Klebsiella pneumoniae Klebsiella pneumoniae MIC = 1230 nM 20034711
NPT172 Organism Proteus mirabilis Proteus mirabilis MIC = 1230 nM 20034711
NPT195 Organism Vesicular stomatitis virus Vesicular stomatitis virus EC50 > 10 nM 20034711
NPT70 Organism Respiratory syncytial virus Respiratory syncytial virus EC50 > 10 nM 20034711
NPT190 Organism Human herpesvirus 1 Human herpesvirus 1 EC50 > 10 nM 20034711
NPT1141 Organism Human herpesvirus 2 Human herpesvirus 2 EC50 = 10 nM 20034711
NPT334 Organism Vaccinia virus Vaccinia virus EC50 = 10 nM 20034711
NPT195 Organism Vesicular stomatitis virus Vesicular stomatitis virus EC50 = 10 nM 20034711
NPT190 Organism Human herpesvirus 1 Human herpesvirus 1 EC50 = 10 nM 20034711
NPT336 Organism Human parainfluenza virus 3 Human parainfluenza virus 3 EC50 > 10 nM 20034711
NPT3878 Organism Mammalian orthoreovirus 1 Mammalian orthoreovirus 1 EC50 > 10 nM 20034711
NPT23 Individual Protein Integrase Human immunodeficiency virus 1 IC50 = 40000 nM 19813754
NPT23 Individual Protein Integrase Human immunodeficiency virus 1 IC50 = 30000 nM 19813754
NPT202 Individual Protein Protease Human immunodeficiency virus 1 IC50 = 100000 nM 19813754
NPT2 Others Unspecified IC50 = 250000 nM 19813754
NPT2 Others Unspecified Inhibition = 81.1 % 19653644
NPT2 Others Unspecified Inhibition = 92.4 % 19653644
NPT2 Others Unspecified Inhibition = 91 % 19653644
NPT2 Others Unspecified Inhibition = 92.9 % 19653644
NPT2 Others Unspecified Inhibition = 96.8 % 19653644
NPT2 Others Unspecified Inhibition = 59 % 19653644
NPT2 Others Unspecified Inhibition = 99 % 19653644
NPT2 Others Unspecified Inhibition = 94.5 % 19653644
NPT2 Others Unspecified Inhibition = 31.9 % 19653644
NPT2 Others Unspecified Inhibition = 41 % 19653644
NPT2 Others Unspecified Inhibition = 53.3 % 19653644
NPT2 Others Unspecified Inhibition = 89 % 19653644
NPT2 Others Unspecified Inhibition = 92 % 19653644
NPT4250 Individual Protein Potassium channel subfamily K member 2 Bos taurus IC50 = 930 nM 19653644
NPT2 Others Unspecified FC = 2 19653644
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 8300 nM 19778086
NPT848 Cell Line N9 Homo sapiens Inhibition = 86.6 % 19691309
NPT848 Cell Line N9 Homo sapiens Inhibition = 75.6 % 19691309
NPT848 Cell Line N9 Homo sapiens Inhibition = 56.1 % 19691309
NPT848 Cell Line N9 Homo sapiens Inhibition = 35.2 % 19691309
NPT848 Cell Line N9 Homo sapiens IC50 = 13500 nM 19691309
NPT2 Others Unspecified Inhibition = 36 % 20346654
NPT906 Individual Protein Testosterone 17-beta-dehydrogenase 3 Rattus norvegicus IC50 = 9000 nM 20346654
NPT906 Individual Protein Testosterone 17-beta-dehydrogenase 3 Rattus norvegicus IC50 = 2300 nM 20346654
NPT958 Individual Protein Estradiol 17-beta-dehydrogenase 3 Homo sapiens IC50 = 67300 nM 20346654
NPT2 Others Unspecified Activity = 30 % 20227282
NPT2 Others Unspecified Inhibition = 78 % 20227282
NPT2 Others Unspecified Inhibition = 127 % 20227282
NPT2 Others Unspecified Activity = 40 % 20227282
NPT2 Others Unspecified Activity = 65 % 20227282
NPT2 Others Unspecified Activity = 50 % 20227282
NPT2 Others Unspecified Activity = 45 % 20227282
NPT2 Others Unspecified IC50 = 75700 nM 20297825
NPT83 Cell Line MCF7 Homo sapiens IC50 = 51500 nM 20297825
NPT65 Cell Line HepG2 Homo sapiens IC50 = 43800 nM 20297825
NPT306 Cell Line PC-3 Homo sapiens IC50 = 22700 nM 20297825
NPT492 Cell Line Caco-2 Homo sapiens IC50 = 48600 nM 20297825
NPT2 Others Unspecified Activity = 24.15 % 20170988
NPT2 Others Unspecified Activity = 79.9 % 20170988
NPT2 Others Unspecified Activity = 7.3 % 20170988
NPT2 Others Unspecified Activity = 1.89 % 20170988
NPT2 Others Unspecified Inhibition = 45 % 20452207
NPT2 Others Unspecified EC50 = 10000 nM 20452207
NPT114 Cell Line LoVo Homo sapiens IC50 = 24000 nM 20466556
NPT2 Others Unspecified IC50 = 22000 nM 20466556
NPT1125 Cell Line T98G Homo sapiens IC50 = 25000 nM 20466556
NPT2 Others Unspecified IC50 = 18000 nM 20466556
NPT169 Cell Line B16-F10 Mus musculus IC50 = 10000 nM 20466556
NPT2337 Cell Line OE33 Homo sapiens IC50 = 35000 nM 20466556
NPT2 Others Unspecified IC50 = 27000 nM 20466556
NPT306 Cell Line PC-3 Homo sapiens IC50 = 33000 nM 20466556
NPT83 Cell Line MCF7 Homo sapiens IC50 = 24000 nM 20466556
NPT81 Cell Line A549 Homo sapiens IC50 = 27000 nM 20466556
NPT1970 Cell Line THP-1 Homo sapiens IC50 = 1210 nM 20561785
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 4.2 ug/ml 19299148
NPT6 Organism Plasmodium falciparum Plasmodium falciparum IC50 = 3.5 ug/ml 19299148
NPT2 Others Unspecified IC50 = 15000 nM 20728364
NPT82 Cell Line MDA-MB-231 Homo sapiens EC50 = 7600 nM 20728364
NPT784 Cell Line MDA-MB-468 Homo sapiens EC50 = 9700 nM 20728364
NPT134 Cell Line SK-BR-3 Homo sapiens IC50 = 2400 nM 20728364
NPT947 Individual Protein Carbonic anhydrase I Homo sapiens Ki = 2410 nM 20674354
NPT233 Individual Protein Carbonic anhydrase II Homo sapiens Ki = 380 nM 20674354
NPT1146 Individual Protein Carbonic anhydrase III Homo sapiens Ki = 11300 nM 20674354
NPT1062 Individual Protein Carbonic anhydrase IV Homo sapiens Ki = 4970 nM 20674354
NPT1143 Individual Protein Carbonic anhydrase VA Homo sapiens Ki = 10250 nM 20674354
NPT1144 Individual Protein Carbonic anhydrase VB Homo sapiens Ki = 9460 nM 20674354
NPT1063 Individual Protein Carbonic anhydrase VI Homo sapiens Ki = 9940 nM 20674354
NPT955 Individual Protein Carbonic anhydrase VII Homo sapiens Ki = 9300 nM 20674354
NPT948 Individual Protein Carbonic anhydrase IX Homo sapiens Ki = 4050 nM 20674354
NPT949 Individual Protein Carbonic anhydrase XII Homo sapiens Ki = 3480 nM 20674354
NPT3101 Individual Protein Carbonic anhydrase XIII Homo sapiens Ki = 6850 nM 20674354
NPT954 Individual Protein Carbonic anhydrase XIV Homo sapiens Ki = 11730 nM 20674354
NPT1147 Individual Protein Carbonic anhydrase 15 Mus musculus Ki = 5090 nM 20674354
NPT4251 Individual Protein Cell division protein ftsZ Bacillus subtilis (strain 168) IC50 = 30000 nM 20615583
NPT83 Cell Line MCF7 Homo sapiens IC50 = 24460 nM 20805034
NPT83 Cell Line MCF7 Homo sapiens FC = 4 20805034
NPT115 Organism Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Ra MIC = 100 ug/ml 20691508
NPT492 Cell Line Caco-2 Homo sapiens IC50 = 15000 nM 20831222
NPT519 Cell Line SH-SY5Y Homo sapiens IC50 = 12800 nM 20831222
NPT76 Cell Line C6 Rattus norvegicus IC50 = 16100 nM 20831222
NPT941 Cell Line HaCaT Homo sapiens IC50 = 21900 nM 20831222
NPT886 Cell Line NIH3T3 Mus musculus IC50 = 14200 nM 20831222
NPT2 Others Unspecified Inhibition < 10 % 20951593
NPT197 Protein-Protein Interaction Menin/Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 31622.8 nM PubChem BioAssay data set
NPT197 Protein-Protein Interaction Menin/Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 15848.9 nM PubChem BioAssay data set
NPT197 Protein-Protein Interaction Menin/Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 28183.8 nM PubChem BioAssay data set
NPT149 Individual Protein Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Homo sapiens Potency = 25118.9 nM PubChem BioAssay data set
NPT48 Individual Protein Lysine-specific demethylase 4D-like Homo sapiens Potency = 19952.6 nM PubChem BioAssay data set
NPT48 Individual Protein Lysine-specific demethylase 4D-like Homo sapiens Potency = 28183.8 nM PubChem BioAssay data set
NPT2930 Individual Protein Hemoglobin beta chain Homo sapiens Potency = 25118.9 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 15848.9 nM PubChem BioAssay data set
NPT1038 Individual Protein Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 44668.4 nM PubChem BioAssay data set
NPT50 Individual Protein Tyrosyl-DNA phosphodiesterase 1 Homo sapiens Potency = 5623.4 nM PubChem BioAssay data set
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 28183.8 nM PubChem BioAssay data set
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 39810.7 nM PubChem BioAssay data set
NPT791 Individual Protein Cruzipain Trypanosoma cruzi Potency = 25118.9 nM PubChem BioAssay data set
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 7079.5 nM PubChem BioAssay data set
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 3162.3 nM PubChem BioAssay data set
NPT531 Individual Protein Nuclear receptor ROR-gamma Mus musculus Potency = 35481.3 nM PubChem BioAssay data set
NPT531 Individual Protein Nuclear receptor ROR-gamma Mus musculus Potency = 22387.2 nM PubChem BioAssay data set
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 19952.6 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 14581 nM PubChem BioAssay data set
NPT3 Individual Protein Thioredoxin glutathione reductase Schistosoma mansoni Potency = 12589.3 nM PubChem BioAssay data set
NPT792 Individual Protein Arachidonate 15-lipoxygenase Homo sapiens Potency = 15848.9 nM PubChem BioAssay data set
NPT282 Individual Protein MAP kinase ERK2 Homo sapiens Potency = 10000 nM PubChem BioAssay data set
NPT2930 Individual Protein Hemoglobin beta chain Homo sapiens Potency = 31622.8 nM PubChem BioAssay data set
NPT197 Protein-Protein Interaction Menin/Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 25118.9 nM PubChem BioAssay data set
NPT197 Protein-Protein Interaction Menin/Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 35481.3 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 25118.9 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 31622.8 nM PubChem BioAssay data set
NPT45 Individual Protein Ubiquitin carboxyl-terminal hydrolase 2 Homo sapiens Potency = 10000 nM PubChem BioAssay data set
NPT151 Individual Protein 15-hydroxyprostaglandin dehydrogenase [NAD+] Homo sapiens Potency = 22387.2 nM PubChem BioAssay data set
NPT531 Individual Protein Nuclear receptor ROR-gamma Mus musculus Potency = 15848.9 nM PubChem BioAssay data set
NPT539 Individual Protein Cellular tumor antigen p53 Homo sapiens Potency = 15848.9 nM PubChem BioAssay data set
NPT109 Individual Protein Cytochrome P450 3A4 Homo sapiens Potency = 25118.9 nM PubChem BioAssay data set
NPT113 Cell Line RAW264.7 Mus musculus Inhibition = 35.6 % 20934787
NPT113 Cell Line RAW264.7 Mus musculus Inhibition = 75.7 % 20934787
NPT2 Others Unspecified Activity = 96.8 % 21190861
NPT1 Others Radical scavenging activity Activity = 35 % 21190861
NPT32 Organism Mus musculus Mus musculus Activity = 106 % 21190861
NPT2 Others Unspecified Inhibition = 51.77 % 21211982
NPT323 Cell Line SW-620 Homo sapiens GI50 = 32000 nM 21183341
NPT2 Others Unspecified IC50 = 9600 nM 21112783
NPT451 Organism Helicobacter pylori Helicobacter pylori MIC = 5 ug/ml 19204190
NPT451 Organism Helicobacter pylori Helicobacter pylori MIC = 15 ug/ml 19204190
NPT451 Organism Helicobacter pylori Helicobacter pylori MIC = 50 ug/ml 19204190
NPT2 Others Unspecified MIC = 20 ug/ml 19204190
NPT451 Organism Helicobacter pylori Helicobacter pylori MIC = 30 ug/ml 19204190
NPT3704 Individual Protein Multidrug resistance protein CDR1 Candida albicans IC50 = 14200 nM 19470507
NPT3704 Individual Protein Multidrug resistance protein CDR1 Candida albicans IC50 = 40000 nM 19470507
NPT20 Organism Candida albicans Candida albicans IC50 = 421600 nM 19470507
NPT20 Organism Candida albicans Candida albicans IC50 = 492800 nM 19470507
NPT20 Organism Candida albicans Candida albicans IC50 = 410600 nM 19470507
NPT20 Organism Candida albicans Candida albicans IC50 = 498000 nM 19470507
NPT20 Organism Candida albicans Candida albicans IC50 = 454600 nM 19470507
NPT20 Organism Candida albicans Candida albicans Ratio IC50 = 1.16 19470507
NPT20 Organism Candida albicans Candida albicans Ratio IC50 = 0.99 19470507
NPT20 Organism Candida albicans Candida albicans Ratio IC50 = 1.18 19470507
NPT20 Organism Candida albicans Candida albicans Ratio IC50 = 1.07 19470507
NPT1566 Individual Protein Glyoxalase I Homo sapiens Ki = 10000 nM 21237663
NPT762 Cell Line A-431 Homo sapiens IC50 = 13800 nM 21215629
NPT380 Cell Line U-251 Homo sapiens IC50 = 13800 nM 21215629
NPT165 Cell Line HeLa Homo sapiens IC50 = 27400 nM 21215629
NPT65 Cell Line HepG2 Homo sapiens IC50 = 31600 nM 21215629
NPT146 Cell Line SK-OV-3 Homo sapiens IC50 = 37700 nM 21215629
NPT81 Cell Line A549 Homo sapiens IC50 = 42600 nM 21215629
NPT83 Cell Line MCF7 Homo sapiens IC50 = 48000 nM 21215629
NPT1171 Cell Line HEp-2 Homo sapiens IC50 = 56900 nM 21215629
NPT1120 Individual Protein Pancreatic triacylglycerol lipase Sus scrofa IC50 > 250000 nM 21282056
NPT30 Individual Protein Cyclooxygenase-1 Homo sapiens Inhibition = 59.01 % 21345672
NPT31 Individual Protein Cyclooxygenase-2 Homo sapiens Inhibition = 20.32 % 21345672
NPT30 Individual Protein Cyclooxygenase-1 Homo sapiens IC50 = 35090 nM 21345672
NPT31 Individual Protein Cyclooxygenase-2 Homo sapiens IC50 = 79200 nM 21345672
NPT1083 Cell Line A-375 Homo sapiens Activity = 3.4 % 21188975
NPT1083 Cell Line A-375 Homo sapiens Activity = 10.3 % 21188975
NPT1083 Cell Line A-375 Homo sapiens Activity = 30.5 % 21188975
NPT532 Individual Protein Lysine-specific demethylase 4A Homo sapiens Potency 50118.7 nM PubChem BioAssay data set
NPT226 Individual Protein Beta-2 adrenergic receptor Homo sapiens Potency 23109.3 nM PubChem BioAssay data set
NPT1005 Individual Protein Tumor susceptibility gene 101 protein Homo sapiens Potency 31622.8 nM PubChem BioAssay data set
NPT539 Individual Protein Cellular tumor antigen p53 Homo sapiens Potency 15848.9 nM PubChem BioAssay data set
NPT799 Individual Protein Intestinal alkaline phosphatase Mus musculus IC50 = 12000 nM PubChem BioAssay data set
NPT801 Individual Protein Intestinal alkaline phosphatase Homo sapiens IC50 = 7410 nM PubChem BioAssay data set
NPT798 Individual Protein Alkaline phosphatase placental-like Homo sapiens IC50 = 63500 nM PubChem BioAssay data set
NPT63 Individual Protein Bromodomain adjacent to zinc finger domain protein 2B Homo sapiens Potency 44668.4 nM PubChem BioAssay data set
NPT1139 Individual Protein Arachidonate 15-lipoxygenase, type II Homo sapiens Potency 10000 nM PubChem BioAssay data set
NPT64 Individual Protein ATPase family AAA domain-containing protein 5 Homo sapiens Potency 25918.5 nM PubChem BioAssay data set
NPT802 Individual Protein Alkaline phosphatase, tissue-nonspecific isozyme Homo sapiens IC50 > 100000 nM PubChem BioAssay data set
NPT801 Individual Protein Intestinal alkaline phosphatase Homo sapiens IC50 = 44100 nM PubChem BioAssay data set
NPT2 Others Unspecified Inhibition = 80 % 21435875
NPT2 Others Unspecified Activity = 90 % 21435875
NPT2 Others Unspecified Inhibition = 52.1 % 21397508
NPT2 Others Unspecified Ki = 49.8 nM 21417461
NPT2 Others Unspecified Inhibition = 34.4 % 21236667
NPT2 Others Unspecified Inhibition = 33.26 % 21367493
NPT927 Cell Line PBMC Homo sapiens IC50 = 2.71 ug/ml 21600765
NPT2 Others Unspecified Inhibition = 50 % 21497959
NPT397 Cell Line NCI-H460 Homo sapiens IC50 = 20290 nM 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 70 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 12.02 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 87.91 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 7.97 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 3.66 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 0.46 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 89.15 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 8.57 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 2.06 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 0.23 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 83.6 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 4.06 % 21504179
NPT397 Cell Line NCI-H460 Homo sapiens Activity = 0.32 % 21504179
NPT1 Others Radical scavenging activity EC50 = 22600 nM 21601463
NPT1 Others Radical scavenging activity Activity = 10 % 21601463
NPT1566 Individual Protein Glyoxalase I Homo sapiens Ki = 10300 nM 21689932
NPT2 Others Unspecified Inhibition = 38 % 21514701
NPT68 Individual Protein Aldose reductase Rattus norvegicus Inhibition = 12 % 21514701
NPT397 Cell Line NCI-H460 Homo sapiens GI50 = 16700 nM 21514701
NPT397 Cell Line NCI-H460 Homo sapiens TGI = 50100 nM 21514701
NPT83 Cell Line MCF7 Homo sapiens GI50 = 4700 nM 21514701
NPT83 Cell Line MCF7 Homo sapiens TGI = 8300 nM 21514701
NPT395 Cell Line SF-268 Homo sapiens GI50 = 5100 nM 21514701
NPT395 Cell Line SF-268 Homo sapiens TGI = 9200 nM 21514701
NPT397 Cell Line NCI-H460 Homo sapiens LC50 = 83400 nM 21514701
NPT83 Cell Line MCF7 Homo sapiens LC50 = 67200 nM 21514701
NPT395 Cell Line SF-268 Homo sapiens LC50 = 61000 nM 21514701
NPT81 Cell Line A549 Homo sapiens GI50 = 15230 nM 21070043
NPT81 Cell Line A549 Homo sapiens GI50 = 9440 nM 21070043
NPT2 Others Unspecified GI50 = 16160 nM 21070043
NPT397 Cell Line NCI-H460 Homo sapiens GI50 = 12130 nM 21070043
NPT1668 Cell Line NCI-H157 Homo sapiens GI50 = 19250 nM 21070043
NPT2 Others Unspecified IC50 = 9500 nM 21070043
NPT2 Others Unspecified IC50 = 12100 nM 21840724
NPT2 Others Unspecified Inhibition = 71.3 % 21840724
NPT2 Others Unspecified Ratio = 2.5 21840724
NPT81 Cell Line A549 Homo sapiens Activity = 16 % 21830815
NPT165 Cell Line HeLa Homo sapiens Activity = 8 % 21830815
NPT2 Others Unspecified Ki = 5.01 10'5/M 21830815
NPT81 Cell Line A549 Homo sapiens IC50 = 17000 nM 21830815
NPT165 Cell Line HeLa Homo sapiens IC50 = 18000 nM 21830815
NPT165 Cell Line HeLa Homo sapiens Activity = 18 % 21830815
NPT2 Others Unspecified IC50 = 20000 nM 21830815
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus Inhibition = 34.5 % 21871694
NPT2 Others Unspecified Inhibition = 41.8 % 21871694
NPT2 Others Unspecified Ki = 3.57 nM 21885280
NPT198 Individual Protein Vitamin D receptor Homo sapiens Potency 44668.4 nM PubChem BioAssay data set
NPT198 Individual Protein Vitamin D receptor Homo sapiens Potency 50118.7 nM PubChem BioAssay data set
NPT198 Individual Protein Vitamin D receptor Homo sapiens Potency 39810.7 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 5011.9 nM PubChem BioAssay data set
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Potency 19011.5 nM PubChem BioAssay data set
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Potency 2078.7 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 31622.8 nM PubChem BioAssay data set
NPT4252 Individual Protein Toll-like receptor 9 Homo sapiens IC50 = 15266 nM PubChem BioAssay data set
NPT803 Individual Protein Flap endonuclease 1 Homo sapiens Potency 89125.1 nM PubChem BioAssay data set
NPT8 Individual Protein DNA polymerase iota Homo sapiens Potency 19952.6 nM PubChem BioAssay data set
NPT199 Individual Protein DNA polymerase kappa Homo sapiens Potency 31622.8 nM PubChem BioAssay data set
NPT189 Cell Line Vero Chlorocebus aethiops CC50 19880 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 12589.3 nM PubChem BioAssay data set
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Potency 18526 nM PubChem BioAssay data set
NPT1161 Cell Line CHO Cricetulus griseus IC50 = 34611 nM PubChem BioAssay data set
NPT154 Individual Protein Mothers against decapentaplegic homolog 3 Homo sapiens Potency 35481.3 nM PubChem BioAssay data set
NPT226 Individual Protein Beta-2 adrenergic receptor Homo sapiens Potency 6513.1 nM PubChem BioAssay data set
NPT4253 Individual Protein Beta Lactamase Pseudomonas aeruginosa IC50 = 10769 nM PubChem BioAssay data set
NPT444 Individual Protein Ubiquitin carboxyl-terminal hydrolase 1 Homo sapiens Potency 31622.8 nM PubChem BioAssay data set
NPT444 Individual Protein Ubiquitin carboxyl-terminal hydrolase 1 Homo sapiens Potency 12589.3 nM PubChem BioAssay data set
NPT2 Others Unspecified Inhibition = 52.1 % 22019228
NPT2 Others Unspecified Inhibition = 30.7 % 22019228
NPT1 Others Radical scavenging activity EC50 = 13000 nM 22029378
NPT2 Others Unspecified IC50 = 18000 nM 22029378
NPT2 Others Unspecified IC50 = 7000 nM 22029378
NPT2 Others Unspecified IC50 = 4700 nM 22029378
NPT2 Others Unspecified IC50 = 26000 nM 22029378
NPT2 Others Unspecified IC50 = 16000 nM 22029378
NPT179 Cell Line A2780 Homo sapiens IC50 = 38000 nM 22029378
NPT179 Cell Line A2780 Homo sapiens IC50 = 12000 nM 22029378
NPT179 Cell Line A2780 Homo sapiens IC50 = 8000 nM 22029378
NPT179 Cell Line A2780 Homo sapiens IC50 = 28000 nM 22029378
NPT179 Cell Line A2780 Homo sapiens IC50 = 18000 nM 22029378
NPT179 Cell Line A2780 Homo sapiens IC50 = 11000 nM 22029378
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 13000 nM 22029378
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 4000 nM 22029378
NPT114 Cell Line LoVo Homo sapiens IC50 = 16000 nM 22029378
NPT114 Cell Line LoVo Homo sapiens IC50 = 10000 nM 22029378
NPT2 Others Unspecified Ratio IC50 = 3.4 22029378
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus IC50 > 100000 nM 22041172
NPT2 Others Unspecified Inhibition = 52.1 % 22041172
NPT2 Others Unspecified IC50 = 20300 nM 22137846
NPT83 Cell Line MCF7 Homo sapiens IC50 = 49800 nM 22222040
NPT519 Cell Line SH-SY5Y Homo sapiens IC50 = 105000 nM 22222040
NPT65 Cell Line HepG2 Homo sapiens IC50 = 87500 nM 22222040
NPT397 Cell Line NCI-H460 Homo sapiens IC50 = 51300 nM 22222040
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus Inhibition = 34.5 % 22341944
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus Inhibition = 2.1 % 22341944
NPT445 Individual Protein Peripheral myelin protein 22 Rattus norvegicus Potency 28695.4 nM PubChem BioAssay data set
NPT484 Individual Protein Luciferin 4-monooxygenase Photinus pyralis Potency 32196.8 nM PubChem BioAssay data set
NPT2 Others Unspecified Inhibition = 48.76 % 22444876
NPT393 Cell Line HCT-116 Homo sapiens Activity = 48.97 % 22409967
NPT393 Cell Line HCT-116 Homo sapiens Activity = 5.62 % 22409967
NPT393 Cell Line HCT-116 Homo sapiens Activity = 45.42 % 22409967
NPT2907 Organism Burkholderia pseudomallei Burkholderia pseudomallei IZ = 8 mm 22440624
NPT2907 Organism Burkholderia pseudomallei Burkholderia pseudomallei IZ = 9 mm 22440624
NPT19 Organism Escherichia coli Escherichia coli IZ = 8 mm 22440624
NPT19 Organism Escherichia coli Escherichia coli IZ = 10 mm 22440624
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa IZ = 11 mm 22440624
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa IZ = 9 mm 22440624
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium IZ = 12 mm 22440624
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium IZ = 10 mm 22440624
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium IZ = 9 mm 22440624
NPT19 Organism Escherichia coli Escherichia coli MIC = 40000000 nM 22440624
NPT2907 Organism Burkholderia pseudomallei Burkholderia pseudomallei MIC = 80000000 nM 22440624
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC = 80000000 nM 22440624
NPT566 Organism Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium MIC = 80000000 nM 22440624
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 80000000 nM 22440624
NPT3540 Organism Cochliobolus lunatus Cochliobolus lunatus IZ = 11 mm 22440624
NPT3540 Organism Cochliobolus lunatus Cochliobolus lunatus IZ = 9 mm 22440624
NPT2567 Organism Trichoderma viride Hypocrea rufa IZ = 9 mm 22440624
NPT2567 Organism Trichoderma viride Hypocrea rufa MIC = 80000000 nM 22440624
NPT65 Cell Line HepG2 Homo sapiens IC50 = 50000000 nM 22440624
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 50000000 nM 22440624
NPT3558 Cell Line QG-56 IC50 = 100000000 nM 22440624
NPT3540 Organism Cochliobolus lunatus Cochliobolus lunatus MIC = 80000000 nM 22440624
NPT2 Others Unspecified Inhibition = 52.1 % 22472046
NPT2 Others Unspecified IC50 = 18700 nM 22472046
NPT306 Cell Line PC-3 Homo sapiens IC50 = 19370 nM 22551677
NPT461 Cell Line PANC-1 Homo sapiens IC50 = 23680 nM 22551677
NPT139 Cell Line HT-29 Homo sapiens IC50 = 18740 nM 22551677
NPT858 Cell Line LNCaP Homo sapiens IC50 = 36400 nM 22672984
NPT306 Cell Line PC-3 Homo sapiens IC50 = 36000 nM 22672984
NPT81 Cell Line A549 Homo sapiens IC50 = 62590 nM 22546674
NPT90 Cell Line DU-145 Homo sapiens IC50 = 38170 nM 22546674
NPT373 Cell Line SK-MEL-5 Homo sapiens IC50 = 50370 nM 22546674
NPT1081 Cell Line BXPC-3 Homo sapiens IC50 = 11430 nM 22546674
NPT65 Cell Line HepG2 Homo sapiens IC50 = 59370 nM 22546674
NPT139 Cell Line HT-29 Homo sapiens IC50 = 15900 nM 22546674
NPT83 Cell Line MCF7 Homo sapiens IC50 = 65160 nM 22546674
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 64670 nM 22546674
NPT2 Others Unspecified Activity = 37.93 % 22546674
NPT2 Others Unspecified IC50 = 2750 nM 22832313
NPT81 Cell Line A549 Homo sapiens IC50 = 11580 nM 22889562
NPT2 Others Unspecified IC50 = 5760 nM 22889562
NPT660 Cell Line SW480 Homo sapiens IC50 = 10170 nM 22889562
NPT83 Cell Line MCF7 Homo sapiens IC50 = 15660 nM 22889562
NPT65 Cell Line HepG2 Homo sapiens IC50 = 20690 nM 22889562
NPT2 Others Unspecified IC50 = 21360 nM 22889562
NPT1 Others Radical scavenging activity IC50 = 35100 nM 22884407
NPT1 Others Radical scavenging activity Activity = 35 % 22126405
NPT10 Individual Protein Geminin Homo sapiens Potency 33498.3 nM PubChem BioAssay data set
NPT10 Individual Protein Geminin Homo sapiens Potency 18356.4 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 15848.9 nM PubChem BioAssay data set
NPT100 Individual Protein Glutaminase kidney isoform, mitochondrial Homo sapiens Potency 35481.3 nM PubChem BioAssay data set
NPT477 Individual Protein DNA dC->dU-editing enzyme APOBEC-3G Homo sapiens Potency 22387.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 11220.2 nM PubChem BioAssay data set
NPT10 Individual Protein Geminin Homo sapiens Potency 23109.3 nM PubChem BioAssay data set
NPT10 Individual Protein Geminin Homo sapiens Potency 29855.4 nM PubChem BioAssay data set
NPT478 Individual Protein Ataxin-2 Homo sapiens Potency 22387.2 nM PubChem BioAssay data set
NPT755 Individual Protein Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Homo sapiens Potency 19952.6 nM PubChem BioAssay data set
NPT152 Individual Protein Nuclear factor erythroid 2-related factor 2 Homo sapiens Potency 22387.2 nM PubChem BioAssay data set
NPT1417 Individual Protein Transcriptional regulator ERG Homo sapiens Potency 15848.9 nM PubChem BioAssay data set
NPT4255 Individual Protein Toll-like receptor 4 Mus musculus IC50 = 6000 nM 22985959
NPT1674 Individual Protein CaM kinase II alpha Homo sapiens IC50 = 13000 nM 22989913
NPT1674 Individual Protein CaM kinase II alpha Homo sapiens IC50 = 21000 nM 22989913
NPT1674 Individual Protein CaM kinase II alpha Homo sapiens IC50 = 45000 nM 22989913
NPT1674 Individual Protein CaM kinase II alpha Homo sapiens IC50 = 34000 nM 22989913
NPT1674 Individual Protein CaM kinase II alpha Homo sapiens IC50 = 33000 nM 22989913
NPT2 Others Unspecified IC50 = 37000 nM 22989913
NPT2 Others Unspecified IC50 = 112000 nM 22989913
NPT2 Others Unspecified IC50 = 64000 nM 22989913
NPT2 Others Unspecified IC50 = 143000 nM 22989913
NPT2 Others Unspecified IC50 = 80000 nM 22989913
NPT2 Others Unspecified IC50 = 33000 nM 22989913
NPT2 Others Unspecified IC50 = 69000 nM 22989913
NPT2 Others Unspecified Inhibition = 52.2 % 22944335
NPT1 Others Radical scavenging activity IC50 = 35100 nM 22995623
NPT740 Individual Protein Beta-secretase 1 Homo sapiens IC50 = 5700 nM 23041347
NPT2 Others Unspecified IC50 = 10400 nM 23041347
NPT2 Others Unspecified IC50 = 10000 nM 23164658
NPT2 Others Unspecified Ratio CC50/IC50 = 3.5 22742496
NPT2 Others Unspecified CC50 = 14800 nM 22742496
NPT194 Organism Dengue virus 2 Dengue virus 2 IC50 = 4200 nM 22742496
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus Inhibition = -2.21 % 23062825
NPT67 Individual Protein Cholinesterase Equus caballus Inhibition = 2.41 % 23062825
NPT35 Others n.a. Activity = 2.57 nmol 22978824
NPT2 Others Unspecified Inhibition = 52.1 % 22978824
NPT4256 Individual Protein Islet amyloid polypeptide Homo sapiens Activity = 15.1 /day 24900390
NPT87 Organism Aspergillus fumigatus Aspergillus fumigatus MIC95 = 20 uM/ml 22683240
NPT21 Organism Aspergillus niger Aspergillus niger MIC95 = 20 uM/ml 22683240
NPT87 Organism Aspergillus fumigatus Aspergillus fumigatus IZ = 12 mm 22683240
NPT21 Organism Aspergillus niger Aspergillus niger IZ = 9 mm 22683240
NPT2894 Organism Providencia rettgeri Providencia rettgeri MIC95 = 20 uM/ml 22683240
NPT314 Organism Bacillus cereus Bacillus cereus MIC95 = 10 uM/ml 22683240
NPT19 Organism Escherichia coli Escherichia coli MIC95 = 20 uM/ml 22683240
NPT1242 Organism Salmonella typhi Salmonella enterica subsp. enterica serovar Typhi MIC95 = 20 uM/ml 22683240
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC95 = 20 uM/ml 22683240
NPT2 Others Unspecified Inhibition = 52.77 % 23127891
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 37800 nM 23153397
NPT65 Cell Line HepG2 Homo sapiens IC50 = 31300 nM 23153397
NPT81 Cell Line A549 Homo sapiens IC50 = 49200 nM 23153397
NPT139 Cell Line HT-29 Homo sapiens GI = 70 % 23245566
NPT139 Cell Line HT-29 Homo sapiens Activity = 45 % 23245566
NPT139 Cell Line HT-29 Homo sapiens Activity = 84 % 23245566
NPT393 Cell Line HCT-116 Homo sapiens Activity = 22.4 % 10.1007/s00044-011-9851-6
NPT393 Cell Line HCT-116 Homo sapiens Activity = 49.6 % 10.1007/s00044-011-9851-6
NPT393 Cell Line HCT-116 Homo sapiens Activity = 61.6 % 10.1007/s00044-011-9851-6
NPT134 Cell Line SK-BR-3 Homo sapiens Activity = 56.5 % 10.1007/s00044-011-9851-6
NPT134 Cell Line SK-BR-3 Homo sapiens Activity = 74 % 10.1007/s00044-011-9851-6
NPT134 Cell Line SK-BR-3 Homo sapiens Activity = 53.7 % 10.1007/s00044-011-9851-6
NPT165 Cell Line HeLa Homo sapiens Activity = 28 % 10.1007/s00044-011-9851-6
NPT165 Cell Line HeLa Homo sapiens Activity = 53.7 % 10.1007/s00044-011-9851-6
NPT165 Cell Line HeLa Homo sapiens Activity = 78.3 % 10.1007/s00044-011-9851-6
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 10000 nM 10.1007/s00044-011-9851-6
NPT134 Cell Line SK-BR-3 Homo sapiens IC50 = 27000 nM 10.1007/s00044-011-9851-6
NPT165 Cell Line HeLa Homo sapiens IC50 = 17000 nM 10.1007/s00044-011-9851-6
NPT2 Others Unspecified Activity = 44.7 % 10.1007/s00044-011-9851-6
NPT2 Others Unspecified Activity = 62.4 % 10.1007/s00044-011-9851-6
NPT2 Others Unspecified Activity = 86.1 % 10.1007/s00044-011-9851-6
NPT1174 Cell Line A375 Homo sapiens Activity = 50.2 % 10.1007/s00044-011-9851-6
NPT1174 Cell Line A375 Homo sapiens Activity = 72.3 % 10.1007/s00044-011-9851-6
NPT1174 Cell Line A375 Homo sapiens Activity = 92 % 10.1007/s00044-011-9851-6
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 21580 nM 10.1007/s00044-010-9521-0
NPT660 Cell Line SW480 Homo sapiens IC50 = 18130 nM 10.1007/s00044-010-9353-y
NPT81 Cell Line A549 Homo sapiens IC50 = 24590 nM 10.1007/s00044-010-9353-y
NPT83 Cell Line MCF7 Homo sapiens IC50 = 21390 nM 10.1007/s00044-010-9353-y
NPT165 Cell Line HeLa Homo sapiens IC50 = 17310 nM 10.1007/s00044-010-9353-y
NPT1548 Organism Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa PAO1 FC = 3 18284200
NPT1548 Organism Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa PAO1 Activity > 2 % 18284200
NPT1548 Organism Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa PAO1 Activity = 25 % 18284200
NPT1548 Organism Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa PAO1 FC = 2 18284200
NPT1548 Organism Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa PAO1 Activity = 60 % 18284200
NPT1548 Organism Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa PAO1 MIC = 30 ug/ml 18284200
NPT111 Cell Line K562 Homo sapiens IC50 = 54300 nM 10.1007/s00044-010-9344-z
NPT682 Cell Line SK-N-MC Homo sapiens IC50 = 57400 nM 10.1007/s00044-010-9344-z
NPT111 Cell Line K562 Homo sapiens IC50 = 49200 nM 10.1007/s00044-010-9344-z
NPT4257 Individual Protein Tubulin alpha 4a Ovis aries IC50 = 26600 nM 10.1007/s00044-010-9344-z
NPT83 Cell Line MCF7 Homo sapiens IC50 = 12000 nM 10.1007/s00044-010-9344-z
NPT165 Cell Line HeLa Homo sapiens IC50 = 13800 nM 10.1007/s00044-010-9344-z
NPT1044 Individual Protein DNA topoisomerase II alpha Homo sapiens IC50 = 15000 nM 10.1007/s00044-011-9587-3
NPT457 Cell Line BT-549 Homo sapiens IC50 = 10500 nM 10.1007/s00044-011-9587-3
NPT91 Cell Line KB Homo sapiens IC50 > 25000 nM 10.1007/s00044-011-9587-3
NPT916 Cell Line SK-MEL Homo sapiens IC50 = 13750 nM 10.1007/s00044-011-9587-3
NPT2 Others Unspecified ED25 = 4.8 nM 10.1007/s00044-009-9199-3
NPT2 Others Unspecified ED50 = 0.0001 nM 10.1007/s00044-009-9199-3
NPT2564 Organism Blumeria graminis Blumeria graminis Activity = 0 % 12617587
NPT829 Organism Puccinia recondita Puccinia recondita Activity = 63 % 12617587
NPT829 Organism Puccinia recondita Puccinia recondita Activity = 76 % 12617587
NPT829 Organism Puccinia recondita Puccinia recondita Activity = 100 % 12617587
NPT825 Organism Phytophthora infestans Phytophthora infestans Activity = 57 % 12617587
NPT825 Organism Phytophthora infestans Phytophthora infestans Activity = 85 % 12617587
NPT825 Organism Phytophthora infestans Phytophthora infestans Activity = 100 % 12617587
NPT635 Organism Botryotinia fuckeliana Botryotinia fuckeliana Activity = 0 % 12617587
NPT635 Organism Botryotinia fuckeliana Botryotinia fuckeliana Activity = 15 % 12617587
NPT635 Organism Botryotinia fuckeliana Botryotinia fuckeliana Activity = 40 % 12617587
NPT635 Organism Botryotinia fuckeliana Botryotinia fuckeliana Activity = 70 % 12617587
NPT529 Organism Rhizoctonia solani Rhizoctonia solani Activity = 26 % 12617587
NPT529 Organism Rhizoctonia solani Rhizoctonia solani Activity = 45 % 12617587
NPT529 Organism Rhizoctonia solani Rhizoctonia solani Activity = 63 % 12617587
NPT529 Organism Rhizoctonia solani Rhizoctonia solani Activity = 85 % 12617587
NPT1198 Organism Magnaporthe grisea Magnaporthe grisea Activity = 0 % 12617587
NPT83 Cell Line MCF7 Homo sapiens Activity = 19 % 10.1007/s00044-012-0116-9
NPT189 Cell Line Vero Chlorocebus aethiops Activity = 24 % 10.1007/s00044-012-0116-9
NPT1374 Cell Line WI-38 Homo sapiens Activity = 51 % 10.1007/s00044-012-0116-9
NPT65 Cell Line HepG2 Homo sapiens Activity = 18 % 10.1007/s00044-012-0116-9
NPT2 Others Unspecified Inhibition = 50.4 % 10.1007/s00044-012-0116-9
NPT2 Others Unspecified Inhibition = 87.64 % 10.1007/s00044-012-0116-9
NPT81 Cell Line A549 Homo sapiens IC50 = 22000 nM 10.1007/s00044-013-0510-y
NPT65 Cell Line HepG2 Homo sapiens IC50 = 16000 nM 10.1007/s00044-013-0510-y
NPT1718 Cell Line A431 Homo sapiens IC50 = 22000 nM 10.1007/s00044-013-0510-y
NPT165 Cell Line HeLa Homo sapiens IC50 = 17000 nM 10.1007/s00044-013-0510-y
NPT83 Cell Line MCF7 Homo sapiens IC50 = 26000 nM 10.1007/s00044-013-0510-y
NPT677 Individual Protein Coagulation factor III Homo sapiens IC50 = 199.63 nM 10.1007/s00044-012-0330-5
NPT285 Individual Protein Epidermal growth factor receptor erbB1 Homo sapiens IC50 = 8600 nM 23245570
NPT2 Others Unspecified IC50 = 18650 nM 23245570
NPT65 Cell Line HepG2 Homo sapiens IC50 = 26990 nM 23245570
NPT2 Others Unspecified Activity = 34 % 23294827
NPT2 Others Unspecified IC50 = 18000 nM 23294827
NPT677 Individual Protein Coagulation factor III Homo sapiens IC50 = 199.63 nM 23199480
NPT2 Others Unspecified IC50 > 300000 nM 23394144
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 73 % 24900645
NPT198 Individual Protein Vitamin D receptor Homo sapiens FC = 8 23276449
NPT198 Individual Protein Vitamin D receptor Homo sapiens EC50 = 20000 nM 23276449
NPT784 Cell Line MDA-MB-468 Homo sapiens IC50 = 196500 nM 23376248
NPT784 Cell Line MDA-MB-468 Homo sapiens Inhibition = 3.88 % 23376248
NPT38 Individual Protein Signal transducer and activator of transcription 3 Homo sapiens IC50 = 19250 nM 23376248
NPT38 Individual Protein Signal transducer and activator of transcription 3 Homo sapiens Inhibition = 30.66 % 23376248
NPT784 Cell Line MDA-MB-468 Homo sapiens IC50 = 196500 nM 23434226
NPT784 Cell Line MDA-MB-468 Homo sapiens Inhibition = 3.88 % 23434226
NPT38 Individual Protein Signal transducer and activator of transcription 3 Homo sapiens IC50 = 19250 nM 23434226
NPT38 Individual Protein Signal transducer and activator of transcription 3 Homo sapiens Inhibition = 41 % 23434226
NPT2 Others Unspecified Potency 16360.1 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 18356.4 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 29092.9 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 20596.2 nM PubChem BioAssay data set
NPT861 Individual Protein Isocitrate dehydrogenase [NADP] cytoplasmic Homo sapiens Potency 29092.9 nM PubChem BioAssay data set
NPT920 Individual Protein Alpha-synuclein Homo sapiens Potency 19952.6 nM PubChem BioAssay data set
NPT160 Individual Protein TAR DNA-binding protein 43 Homo sapiens Potency 35481.3 nM PubChem BioAssay data set
NPT2 Others Unspecified Inhibition = 79 % 23524113
NPT165 Cell Line HeLa Homo sapiens FC = 1.4 23524113
NPT165 Cell Line HeLa Homo sapiens FC = 1.7 23524113
NPT165 Cell Line HeLa Homo sapiens FC = 2.1 23524113
NPT2 Others Unspecified IC50 = 35600 nM 23501115
NPT2 Others Unspecified Activity = 2.5 equiv 23501115
NPT2 Others Unspecified Activity = 2.8 equiv 23501115
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus IC50 = 81050 nM 23583510
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa IZ = 11 mm 23685942
NPT1242 Organism Salmonella typhi Salmonella enterica subsp. enterica serovar Typhi MIC > 80000 nM 23685942
NPT1242 Organism Salmonella typhi Salmonella enterica subsp. enterica serovar Typhi IZ = 9 mm 23685942
NPT1242 Organism Salmonella typhi Salmonella enterica subsp. enterica serovar Typhi IZ = 11 mm 23685942
NPT314 Organism Bacillus cereus Bacillus cereus MIC > 80000 nM 23685942
NPT314 Organism Bacillus cereus Bacillus cereus IZ = 9 mm 23685942
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 80000 nM 23685942
NPT34 Cell Line BV-2 Mus musculus IC50 = 3100 nM 23734721
NPT32 Organism Mus musculus Mus musculus Inhibition = 12.9 % 23685942
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 50000000 nM 23685942
NPT3558 Cell Line QG-56 IC50 = 100000000 nM 23685942
NPT65 Cell Line HepG2 Homo sapiens IC50 = 50000000 nM 23685942
NPT165 Cell Line HeLa Homo sapiens IC50 = 50000000 nM 23685942
NPT2567 Organism Trichoderma viride Hypocrea rufa MIC > 80000 nM 23685942
NPT2567 Organism Trichoderma viride Hypocrea rufa IZ = 9 mm 23685942
NPT3540 Organism Cochliobolus lunatus Cochliobolus lunatus MIC > 80000 nM 23685942
NPT3540 Organism Cochliobolus lunatus Cochliobolus lunatus IZ = 9 mm 23685942
NPT3540 Organism Cochliobolus lunatus Cochliobolus lunatus IZ = 11 mm 23685942
NPT19 Organism Escherichia coli Escherichia coli MIC > 80000 nM 23685942
NPT19 Organism Escherichia coli Escherichia coli IZ = 12 mm 23685942
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC > 80000 nM 23685942
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 50.12 % 23511019
NPT139 Cell Line HT-29 Homo sapiens IC50 = 13200 nM 23644215
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 11540 nM 23644215
NPT139 Cell Line HT-29 Homo sapiens Ratio IC50 = 0.48 23644215
NPT393 Cell Line HCT-116 Homo sapiens Ratio IC50 = 0.39 23644215
NPT2 Others Unspecified IC50 > 100000 nM 23357628
NPT2 Others Unspecified Activity = 4.6 % 23357628
NPT2 Others Unspecified Activity = 5.8 % 23357628
NPT2 Others Unspecified Activity = 13.7 % 23357628
NPT2 Others Unspecified Activity = 22.2 % 23357628
NPT2 Others Unspecified Activity = 45 % 23357628
NPT1 Others Radical scavenging activity IC50 = 26500 nM 23357628
NPT1 Others Radical scavenging activity Activity = 0.3 % 23357628
NPT1 Others Radical scavenging activity Activity = 2.4 % 23357628
NPT1 Others Radical scavenging activity Activity = 23.1 % 23357628
NPT1 Others Radical scavenging activity Activity = 42 % 23357628
NPT1 Others Radical scavenging activity Activity = 87.2 % 23357628
NPT65 Cell Line HepG2 Homo sapiens Activity = 50.2 % 23357628
NPT65 Cell Line HepG2 Homo sapiens Activity = 29.33 % 23357628
NPT65 Cell Line HepG2 Homo sapiens Activity = 20.46 % 23357628
NPT393 Cell Line HCT-116 Homo sapiens IC50 = 41500 nM 23357628
NPT81 Cell Line A549 Homo sapiens IC50 = 32200 nM 23357628
NPT515 Cell Line SGC-7901 Homo sapiens IC50 = 29000 nM 23357628
NPT65 Cell Line HepG2 Homo sapiens IC50 = 78700 nM 23357628
NPT202 Individual Protein Protease Human immunodeficiency virus 1 IC50 = 100000 nM 23742639
NPT23 Individual Protein Integrase Human immunodeficiency virus 1 IC50 = 40000 nM 23742639
NPT2 Others Unspecified IC50 = 16400 nM 23742639
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 42.4 % 23685572
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 24000 nM 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 5.02 U/L 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 7.13 U/L 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 589 K/uL 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 485 K/uL 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 6.83 K/uL 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 4.69 K/uL 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 31.1 % 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 30.6 % 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 0.139 ug 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 0.129 ug 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 1.1 ug 23145932
NPT32 Organism Mus musculus Mus musculus Activity = 0.987 ug 23145932
NPT82 Cell Line MDA-MB-231 Homo sapiens Inhibition > 50 % 23145932
NPT82 Cell Line MDA-MB-231 Homo sapiens Inhibition = 48 % 23145932
NPT82 Cell Line MDA-MB-231 Homo sapiens Inhibition = 53 % 23145932
NPT82 Cell Line MDA-MB-231 Homo sapiens Inhibition = 57 % 23145932
NPT82 Cell Line MDA-MB-231 Homo sapiens Inhibition = 51 % 23145932
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens IC50 = 12350 nM 23799643
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 52.77 % 23799643
NPT1137 Individual Protein 11-beta-hydroxysteroid dehydrogenase 1 Homo sapiens IC50 = 15983 nM 23800686
NPT1138 Individual Protein 11-beta-hydroxysteroid dehydrogenase 2 Homo sapiens Inhibition = 15696 % 23800686
NPT4259 Individual Protein 11-beta-hydroxysteroid dehydrogenase 2 Rattus norvegicus Inhibition = 14939 % 23800686
NPT1137 Individual Protein 11-beta-hydroxysteroid dehydrogenase 1 Homo sapiens IC50 = 4501 nM 23800686
NPT4260 Individual Protein 11-beta-hydroxysteroid dehydrogenase 1 Rattus norvegicus IC50 = 4125 nM 23800686
NPT4260 Individual Protein 11-beta-hydroxysteroid dehydrogenase 1 Rattus norvegicus IC50 = 3921 nM 23800686
NPT2 Others Unspecified IC50 = 11400 nM 23830698
NPT2489 Cell Line MeWo Homo sapiens IC50 = 35500 nM 23830698
NPT2489 Cell Line MeWo Homo sapiens Activity = 90 % 23830698
NPT2553 Individual Protein Aminopeptidase N Homo sapiens IC50 = 10000 nM 23860593
NPT1553 Individual Protein Aminopeptidase N Sus scrofa IC50 = 15500 nM 23860593
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 51.3 % 23932451
NPT1970 Cell Line THP-1 Homo sapiens FC = 1.8 23933533
NPT1970 Cell Line THP-1 Homo sapiens FC = 1.5 23933533
NPT1970 Cell Line THP-1 Homo sapiens FC = 0.9 23933533
NPT1970 Cell Line THP-1 Homo sapiens FC = 0.5 23933533
NPT1970 Cell Line THP-1 Homo sapiens Inhibition = 1.5 % 23933533
NPT1970 Cell Line THP-1 Homo sapiens Inhibition = 38 % 23933533
NPT1970 Cell Line THP-1 Homo sapiens Inhibition = 95.5 % 23933533
NPT1970 Cell Line THP-1 Homo sapiens Inhibition = 102.5 % 23933533
NPT2 Others Unspecified IC50 = 28.3 ug/ml 23933533
NPT2 Others Unspecified IC50 = 17.03 ug/ml 23933533
NPT1 Others Radical scavenging activity IC50 = 11.41 ug/ml 23933533
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 5000 nM 24094143
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens IC50 = 20300 nM 24095756
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 43.5 % 24095756
NPT73 Individual Protein Solute carrier organic anion transporter family member 1B1 Homo sapiens Inhibition = 82.72 % 23571415
NPT72 Individual Protein Solute carrier organic anion transporter family member 1B3 Homo sapiens Inhibition = 115.19 % 23571415
NPT2028 Cell Line SK-N-FI Homo sapiens IC50 = 11300 nM 24183537
NPT136 Cell Line SK-N-SH Homo sapiens IC50 = 6400 nM 24183537
NPT2 Others Unspecified IC50 = 8100 nM 24183537
NPT2 Others Unspecified IC50 = 3900 nM 24256496
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 51.04 % 24148835
NPT737 Cell Line HUVEC Homo sapiens Inhibition = 45 % 24332631
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 29 % 24342238
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 24 % 24342238
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 51.5 % 24269515
NPT2 Others Unspecified EC50 = 20700 nM 24275249
NPT1045 Cell Line U2OS Homo sapiens Activity = 34.8 % 24275249
NPT2 Others Unspecified Inhibition = 59.4 % 24275249
NPT2 Others Unspecified Inhibition = 27.1 % 24275249
NPT2 Others Unspecified Inhibition = 62.8 % 24275249
NPT2 Others Unspecified Inhibition = 82.5 % 24275249
NPT2 Others Unspecified Inhibition = 89.3 % 24275249
NPT2 Others Unspecified Inhibition = 99.4 % 24275249
NPT2 Others Unspecified Inhibition = 98.2 % 24275249
NPT1045 Cell Line U2OS Homo sapiens Activity = 42.4 % 24275249
NPT1045 Cell Line U2OS Homo sapiens Activity = 29 % 24275249
NPT2 Others Unspecified Activity = 93.3 % 24467317
NPT2 Others Unspecified IC50 = 530 nM 24467317
NPT2 Others Unspecified IC50 = 341 molar ratio 24411124
NPT2 Others Unspecified Activity = 100 % 24411124
NPT2 Others Unspecified Activity = 81.7 % 24411124
NPT2 Others Unspecified Activity = 22.8 % 24411124
NPT2 Others Unspecified Activity = 0 % 24411124
NPT113 Cell Line RAW264.7 Mus musculus Inhibition = 20 % 24321865
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 64 % 24589487
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 43.1 % 24589487
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 29 % 24594525
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 24 % 24594525
NPT81 Cell Line A549 Homo sapiens IC50 = 15000 nM 24531225
NPT165 Cell Line HeLa Homo sapiens IC50 = 12600 nM 24531225
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 880 nM 24531225
NPT306 Cell Line PC-3 Homo sapiens IC50 = 1980 nM 24531225
NPT90 Cell Line DU-145 Homo sapiens IC50 = 300 nM 24531225
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 52.21 % 10.1039/C3MD00376K
NPT2 Others Unspecified Ratio IC50 > 1.26 10.1039/C3MD00376K
NPT2 Others Unspecified Potency 1995.3 nM PubChem BioAssay data set
NPT161 Individual Protein Rap guanine nucleotide exchange factor 4 Homo sapiens Potency 35481.3 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 25118.9 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 22387.2 nM PubChem BioAssay data set
NPT831 Individual Protein Serine/threonine-protein kinase PLK1 Homo sapiens Potency 1683.4 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 35481.3 nM PubChem BioAssay data set
NPT2 Others Unspecified IC50 = 6700 nM 24689857
NPT2 Others Unspecified Inhibition = 37 % 24689857
NPT2 Others Unspecified Inhibition = 33 % 24689857
NPT2 Others Unspecified Inhibition = 12 % 24689857
NPT2 Others Unspecified Inhibition = 17 % 24689857
NPT2 Others Unspecified Inhibition = 70 % 24689857
NPT2 Others Unspecified Inhibition = 13 % 24689857
NPT2 Others Unspecified Inhibition = 44 % 24689857
NPT2 Others Unspecified Inhibition = 82 % 24689857
NPT2 Others Unspecified Activity = 17 % 24689857
NPT2 Others Unspecified Activity = 25 % 24689857
NPT2 Others Unspecified Activity = 58 % 24689857
NPT2 Others Unspecified Activity = 71 % 24689857
NPT2 Others Unspecified Activity = 54 % 24689857
NPT2 Others Unspecified Activity = 66 % 24689857
NPT2 Others Unspecified Activity = 75 % 24689857
NPT2 Others Unspecified IC50 = 500 nM 24593150
NPT1 Others Radical scavenging activity EC50 = 26600 nM 24657052
NPT983 Protein Complex Nuclear factor NF-kappa-B complex Homo sapiens IC50 = 8000 nM 24775915
NPT1 Others Radical scavenging activity Activity = 63.9 % 24920381
NPT1119 Individual Protein Arachidonate 12-lipoxygenase Homo sapiens Inhibition = 65 % 24920381
NPT570 Individual Protein Arachidonate 5-lipoxygenase Homo sapiens IC50 = 3900 nM 24920381
NPT30 Individual Protein Cyclooxygenase-1 Homo sapiens IC50 = 8100 nM 24920381
NPT38 Individual Protein Signal transducer and activator of transcription 3 Homo sapiens IC50 = 33900 nM 24920381
NPT983 Protein Complex Nuclear factor NF-kappa-B complex Homo sapiens IC50 = 20900 nM 24920381
NPT858 Cell Line LNCaP Homo sapiens IC50 = 36000 nM 24920381
NPT927 Cell Line PBMC Homo sapiens IC50 = 34800 nM 24920381
NPT152 Individual Protein Nuclear factor erythroid 2-related factor 2 Homo sapiens EC50 = 9900 nM 24920381
NPT570 Individual Protein Arachidonate 5-lipoxygenase Homo sapiens IC50 = 500 nM 24920381
NPT956 Individual Protein Prostaglandin E synthase Homo sapiens IC50 = 600 nM 24920381
NPT956 Individual Protein Prostaglandin E synthase Homo sapiens IC50 = 1200 nM 24920381
NPT570 Individual Protein Arachidonate 5-lipoxygenase Homo sapiens IC50 = 600 nM 24920381
NPT2 Others Unspecified IC50 = 1200 nM 24920381
NPT792 Individual Protein Arachidonate 15-lipoxygenase Homo sapiens IC50 = 1200 nM 24920381
NPT91 Cell Line KB Homo sapiens IC50 = 21360 nM 24857542
NPT189 Cell Line Vero Chlorocebus aethiops IC50 = 35050 nM 24857542
NPT2 Others Unspecified Ratio IC50 = 1.64 24857542
NPT2 Others Unspecified IC50 = 25000 nM 10.1039/C1MD00199J
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 34400 nM 25453798
NPT113 Cell Line RAW264.7 Mus musculus Inhibition = 77.04 % 25453803
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 6200 nM 25453803
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 80 % 25467149
NPT270 Individual Protein Nitric oxide synthase, inducible Mus musculus Inhibition = 97 % 25058929
NPT270 Individual Protein Nitric oxide synthase, inducible Mus musculus IC50 = 800 nM 25058929
NPT2 Others Unspecified IC50 = 6010 nM 24960549
NPT2 Others Unspecified IC50 = 7990 nM 24960549
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens IC50 = 11000 nM 25088549
NPT740 Individual Protein Beta-secretase 1 Homo sapiens IC50 = 5300 nM 25088549
NPT2 Others Unspecified FC = 2 24960549
NPT2 Others Unspecified IC50 = 40000 nM 24960549
NPT2 Others Unspecified IC50 = 26000 nM 24960549
NPT2 Others Unspecified IC50 = 48000 nM 24960549
NPT2 Others Unspecified IC50 = 2500 nM 24960549
NPT2 Others Unspecified IC50 = 4800 nM 24960549
NPT2 Others Unspecified IC50 = 3800 nM 24960549
NPT2 Others Unspecified EC50 = 6000 nM 25051453
NPT2 Others Unspecified Activity = 45 % 24961640
NPT2 Others Unspecified Activity = 60 % 24961640
NPT858 Cell Line LNCaP Homo sapiens Ratio = 2 24961640
NPT2 Others Unspecified Inhibition = 53 % 25093453
NPT2 Others Unspecified IC50 = 6.9 nM 24831826
NPT2 Others Unspecified IC50 = 480000 nM 24831826
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 11020 nM 25113933
NPT2 Others Unspecified IC50 = 18520 nM 25113933
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 1.25 ug/ml 25113933
NPT2 Others Unspecified IC50 = 2.08 ug/ml 25113933
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 6.44 ug/ml 25113933
NPT2 Others Unspecified IC50 = 24.82 ug/ml 25113933
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 11020 nM 24909081
NPT2 Others Unspecified IC50 = 18520 nM 24909081
NPT113 Cell Line RAW264.7 Mus musculus Inhibition = 1.25 % 24909081
NPT2 Others Unspecified Inhibition = 2.08 % 24909081
NPT113 Cell Line RAW264.7 Mus musculus Inhibition = 6.44 % 24909081
NPT2 Others Unspecified Inhibition = 24.82 % 24909081
NPT2 Others Unspecified IC50 = 6460 nM 24657568
NPT333 Cell Line CEM Homo sapiens IC50 = 8160 nM 24657568
NPT165 Cell Line HeLa Homo sapiens IC50 = 21200 nM 24657568
NPT137 Cell Line L1210 Mus musculus IC50 = 15100 nM 24657568
NPT2 Others Unspecified IC50 = 10120 nM 24938495
NPT324 Individual Protein Cyclooxygenase-1 Ovis aries IC50 = 29650 nM 24938495
NPT31 Individual Protein Cyclooxygenase-2 Homo sapiens IC50 > 100000 nM 24938495
NPT4261 Individual Protein Lipoxygenase Glycine max IC50 = 59520 nM 24938495
NPT2 Others Unspecified Inhibition = 81.5 % 24938495
NPT4261 Individual Protein Lipoxygenase Glycine max Inhibition = 68.28 % 24938495
NPT2 Others Unspecified Activity = 0.53 25305717
NPT2 Others Unspecified IC50 = 6000 nM 25277281
NPT1032 Individual Protein Neuraminidase Influenza A virus (strain A/USSR/90/1977 H1N1) IC50 = 10000 nM 25277281
NPT1032 Individual Protein Neuraminidase Influenza A virus (strain A/USSR/90/1977 H1N1) IC50 = 8100 nM 25277281
NPT804 Cell Line HT-22 Mus musculus Inhibition = 36 % 25313922
NPT804 Cell Line HT-22 Mus musculus Inhibition = 18 % 25313922
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 42.3 % 25282654
NPT2 Others Unspecified Ratio = 1.83 25282654
NPT621 Tissue Plasma Homo sapiens Inhibition = 19.2 % 25420236
NPT621 Tissue Plasma Homo sapiens Inhibition = 18.6 % 25420236
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 50.2 % 25542589
NPT2 Others Unspecified Inhibition = 81 % 25577709
NPT2 Others Unspecified Inhibition = 55 % 25577709
NPT2 Others Unspecified Activity = 83.8 % 25577709
NPT2 Others Unspecified Activity = 53.6 % 25577709
NPT2 Others Unspecified Activity = 93.1 % 25577709
NPT2 Others Unspecified Activity = 90.2 % 25577709
NPT2 Others Unspecified Activity = 85.5 % 25577709
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 43.1 % 25678013
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 58 % 25678013
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 51.8 % 25624107
NPT333 Cell Line CEM Homo sapiens IC50 = 15000 nM 25577711
NPT165 Cell Line HeLa Homo sapiens IC50 = 18000 nM 25577711
NPT137 Cell Line L1210 Mus musculus IC50 = 22000 nM 25577711
NPT2 Others Unspecified Ratio IC50 = 1.5 25577711
NPT2 Others Unspecified Activity = 1201.4 umol/ml 25577711
NPT2 Others Unspecified Activity = 1581.9 umol/ml 25577711
NPT1 Others Radical scavenging activity Inhibition = 96.8 % 25577711
NPT2 Others Unspecified Inhibition = 98.7 % 25577711
NPT2 Others Unspecified Inhibition = 47.8 % 25724825
NPT2 Others Unspecified IC50 = 18520 nM 25824662
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 11020 nM 25824662
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 3400 nM 25824662
NPT2 Others Unspecified IC50 = 5600 nM 25824662
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 17500 nM 25824662
NPT2 Others Unspecified IC50 = 67400 nM 25824662
NPT878 Organism Streptococcus mutans Streptococcus mutans MIC > 542900 nM 25746812
NPT2 Others Unspecified IC50 = 91500 nM 25746812
NPT2 Others Unspecified IC50 = 26.8 ug/ml 25881826
NPT927 Cell Line PBMC Homo sapiens IC50 = 12.3 ug/ml 25881826
NPT983 Protein Complex Nuclear factor NF-kappa-B complex Homo sapiens IC50 = 7.7 ug/ml 25881826
NPT2 Others Unspecified Activity = 20.7 % 25881826
NPT2 Others Unspecified Activity = 23 % 25881826
NPT2 Others Unspecified Activity = 23.3 % 25881826
NPT1 Others Radical scavenging activity IC50 = 13530 nM 25728027
NPT2 Others Unspecified IC50 = 48630 nM 25728027
NPT2 Others Unspecified IC50 = 54350 nM 25728027
NPT2 Others Unspecified IC50 = 89820 nM 25728027
NPT2 Others Unspecified IC50 = 39420 nM 25728027
NPT83 Cell Line MCF7 Homo sapiens IC50 = 70200 nM 25728027
NPT2 Others Unspecified IC50 = 59020 nM 25728027
NPT1830 Organism Mycobacterium marinum Mycobacterium marinum IZ = 1.1 mm 25618016
NPT2 Others Unspecified Activity = 35 % 25791674
NPT2 Others Unspecified Kd = 507000 nM 25681711
NPT2 Others Unspecified Activity = 78.8 25681711
NPT2 Others Unspecified Activity = 36.4 25681711
NPT2704 Individual Protein Hemagglutinin Influenza A virus Activity = 16.1 25681711
NPT2704 Individual Protein Hemagglutinin Influenza A virus Activity = 6.8 25681711
NPT2704 Individual Protein Hemagglutinin Influenza A virus Activity = 2.7 25681711
NPT2704 Individual Protein Hemagglutinin Influenza A virus Activity = 0.8 25681711
NPT79 Organism Bacillus subtilis Bacillus subtilis MIC = 16 ug/ml 25938986
NPT19 Organism Escherichia coli Escherichia coli MIC > 128 ug/ml 25938986
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC > 128 ug/ml 25938986
NPT1079 Individual Protein Histone acetyltransferase p300 Homo sapiens Inhibition = 93.45 % 25730130
NPT1079 Individual Protein Histone acetyltransferase p300 Homo sapiens IC50 = 6500 nM 25730130
NPT79 Organism Bacillus subtilis Bacillus subtilis MIC = 32 ug/ml 25938986
NPT18 Organism Pseudomonas aeruginosa Pseudomonas aeruginosa MIC > 128 ug/ml 25938986
NPT1228 Organism Streptococcus pyogenes Streptococcus pyogenes MIC > 128 ug/ml 25938986
NPT2 Others Unspecified Potency 17782.8 nM PubChem BioAssay data set
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 43.1 % 25778991
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 58 % 25778991
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 56.5 % 25778991
NPT306 Cell Line PC-3 Homo sapiens Inhibition = 2.45 % 25961334
NPT306 Cell Line PC-3 Homo sapiens Inhibition = 55.07 % 25961334
NPT90 Cell Line DU-145 Homo sapiens Inhibition = 58.49 % 25961334
NPT90 Cell Line DU-145 Homo sapiens Inhibition = 7.25 % 25961334
NPT858 Cell Line LNCaP Homo sapiens Inhibition = 65.45 % 25961334
NPT858 Cell Line LNCaP Homo sapiens Inhibition = 28.78 % 25961334
NPT165 Cell Line HeLa Homo sapiens Inhibition = 50.3 % 25961334
NPT165 Cell Line HeLa Homo sapiens Inhibition = 13.75 % 25961334
NPT306 Cell Line PC-3 Homo sapiens IC50 = 25430 nM 25961334
NPT306 Cell Line PC-3 Homo sapiens IC50 = 12360 nM 25961334
NPT90 Cell Line DU-145 Homo sapiens IC50 = 26230 nM 25961334
NPT858 Cell Line LNCaP Homo sapiens IC50 = 13610 nM 25961334
NPT165 Cell Line HeLa Homo sapiens IC50 = 12110 nM 25961334
NPT165 Cell Line HeLa Homo sapiens IC50 = 10460 nM 25961334
NPT306 Cell Line PC-3 Homo sapiens Ratio IC50 = 1 25961334
NPT90 Cell Line DU-145 Homo sapiens Ratio IC50 = 1 25961334
NPT858 Cell Line LNCaP Homo sapiens Ratio IC50 = 1 25961334
NPT165 Cell Line HeLa Homo sapiens Ratio IC50 = 1 25961334
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens IC50 = 3900 nM 26099993
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 70 % 26099993
NPT2794 Individual Protein Quinolone resistance protein norA Staphylococcus aureus MIC = 1 ug/ml 10.1039/C4MD00196F
NPT2794 Individual Protein Quinolone resistance protein norA Staphylococcus aureus FC = 8 10.1039/C4MD00196F
NPT2 Others Unspecified MIC = 32 ug/ml 10.1039/C4MD00196F
NPT2 Others Unspecified FC = 0 10.1039/C4MD00196F
NPT2 Others Unspecified MIC = 64 ug/ml 10.1039/C4MD00196F
NPT2795 Individual Protein Fluoroquinolone resistance protein Staphylococcus aureus MIC = 256 ug/ml 10.1039/C4MD00196F
NPT2795 Individual Protein Fluoroquinolone resistance protein Staphylococcus aureus FC = 0 10.1039/C4MD00196F
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 22910 nM 26048786
NPT668 Individual Protein P-glycoprotein 1 Homo sapiens IC50 = 62000 nM 10.1039/C4MD00196F
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 14700 nM 26071636
NPT113 Cell Line RAW264.7 Mus musculus Inhibition = 99.3 % 26071636
NPT113 Cell Line RAW264.7 Mus musculus IC50 = 28800 nM 26071636
NPT35 Others n.a. Inhibition = 88.3 % 26071636
NPT1 Others Radical scavenging activity Inhibition = 84.2 % 26071636
NPT1 Others Radical scavenging activity IC50 = 23600 nM 26071636
NPT2 Others Unspecified Activity = 0.803 mmolequiv/L 26071636
NPT2 Others Unspecified IC50 = 3900 nM 26241103
NPT2 Others Unspecified Inhibition = 86.6 % 26197162
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 51.5 % 26337018
NPT2 Others Unspecified Inhibition = 65.9 % 26337018
NPT1 Others Radical scavenging activity IC50 = 14.83 ug/ml 26264500
NPT2 Others Unspecified IC50 = 34.71 ug/ml 26264500
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 50 % 26288690
NPT90 Cell Line DU-145 Homo sapiens IC50 = 26200 nM 26341135
NPT306 Cell Line PC-3 Homo sapiens IC50 = 25400 nM 26341135
NPT858 Cell Line LNCaP Homo sapiens IC50 = 12100 nM 26341135
NPT2 Others Unspecified EC50 = 7480 nM 26386817
NPT2 Others Unspecified Activity = 58.4 % 26386817
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 70.6 % 10.1039/C4MD00305E
NPT519 Cell Line SH-SY5Y Homo sapiens Inhibition = 37.87 % 10.1039/C4MD00305E
NPT2 Others Unspecified Activity = 8.5 % 26386817
NPT2 Others Unspecified EC50 = 48500 nM 26386817
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 48.74 % 10.1039/C4MD00305E
NPT78 Individual Protein Beta amyloid A4 protein Homo sapiens Inhibition = 42.3 % 26514744
NPT82 Cell Line MDA-MB-231 Homo sapiens IC50 = 15000 nM 26561365
NPT3722 Cell Line 4T1 Mus musculus IC50 = 20000 nM 26561365
NPT2 Others Unspecified IC50 = 20000 nM 26561365

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC109083 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC269843
1.0 High Similarity NPC189844
1.0 High Similarity NPC14007
1.0 High Similarity NPC60962
1.0 High Similarity NPC224814
0.9741 High Similarity NPC229084
0.9741 High Similarity NPC18984
0.9741 High Similarity NPC160900
0.9741 High Similarity NPC106659
0.9646 High Similarity NPC280001
0.9496 High Similarity NPC276014
0.9492 High Similarity NPC246704
0.9487 High Similarity NPC286573
0.9417 High Similarity NPC123228
0.9417 High Similarity NPC5018
0.9417 High Similarity NPC123722
0.9417 High Similarity NPC276466
0.9417 High Similarity NPC151167
0.9412 High Similarity NPC289459
0.9339 High Similarity NPC110313
0.9333 High Similarity NPC179777
0.9333 High Similarity NPC84076
0.9333 High Similarity NPC303680
0.9333 High Similarity NPC120225
0.9333 High Similarity NPC90128
0.9333 High Similarity NPC213552
0.9316 High Similarity NPC158949
0.9262 High Similarity NPC304622
0.9224 High Similarity NPC272471
0.9224 High Similarity NPC137537
0.9224 High Similarity NPC164706
0.9224 High Similarity NPC70744
0.9224 High Similarity NPC107588
0.9224 High Similarity NPC470626
0.918 High Similarity NPC478215
0.9153 High Similarity NPC204466
0.9138 High Similarity NPC39793
0.9138 High Similarity NPC185738
0.9138 High Similarity NPC293619
0.9106 High Similarity NPC83062
0.9091 High Similarity NPC53305
0.9091 High Similarity NPC87113
0.9091 High Similarity NPC257589
0.9083 High Similarity NPC242372
0.9083 High Similarity NPC164778
0.9083 High Similarity NPC4181
0.9083 High Similarity NPC257976
0.9076 High Similarity NPC70752
0.9068 High Similarity NPC2058
0.9068 High Similarity NPC95614
0.9068 High Similarity NPC232316
0.9068 High Similarity NPC165133
0.9068 High Similarity NPC117780
0.9068 High Similarity NPC242885
0.9068 High Similarity NPC56214
0.9068 High Similarity NPC202474
0.9068 High Similarity NPC227217
0.9032 High Similarity NPC66905
0.9016 High Similarity NPC92207
0.9016 High Similarity NPC127937
0.9008 High Similarity NPC60517
0.9008 High Similarity NPC20443
0.9008 High Similarity NPC312404
0.9008 High Similarity NPC273686
0.9008 High Similarity NPC146886
0.9 High Similarity NPC114298
0.8992 High Similarity NPC207613
0.8983 High Similarity NPC310338
0.8983 High Similarity NPC281298
0.8938 High Similarity NPC7097
0.8938 High Similarity NPC36108
0.8938 High Similarity NPC233731
0.8938 High Similarity NPC246358
0.8926 High Similarity NPC238810
0.8917 High Similarity NPC38996
0.8917 High Similarity NPC160380
0.8917 High Similarity NPC184651
0.8917 High Similarity NPC470212
0.8917 High Similarity NPC473853
0.8917 High Similarity NPC113865
0.8917 High Similarity NPC54872
0.8917 High Similarity NPC343720
0.8917 High Similarity NPC324571
0.8917 High Similarity NPC312675
0.8917 High Similarity NPC262156
0.8898 High Similarity NPC277460
0.8889 High Similarity NPC268317
0.888 High Similarity NPC172673
0.8879 High Similarity NPC294941
0.8871 High Similarity NPC226661
0.8843 High Similarity NPC262253
0.8843 High Similarity NPC473411
0.8843 High Similarity NPC71579
0.8843 High Similarity NPC85488
0.8814 High Similarity NPC86947
0.8783 High Similarity NPC156840
0.8783 High Similarity NPC8547
0.8783 High Similarity NPC257124
0.8783 High Similarity NPC297657
0.8783 High Similarity NPC78918
0.8783 High Similarity NPC173746
0.8783 High Similarity NPC139617
0.877 High Similarity NPC163083
0.877 High Similarity NPC31344
0.877 High Similarity NPC471693
0.877 High Similarity NPC317769
0.877 High Similarity NPC280704
0.876 High Similarity NPC201777
0.875 High Similarity NPC61516
0.875 High Similarity NPC135127
0.875 High Similarity NPC232084
0.875 High Similarity NPC247364
0.875 High Similarity NPC111635
0.875 High Similarity NPC119060
0.875 High Similarity NPC10932
0.875 High Similarity NPC237594
0.875 High Similarity NPC476387
0.875 High Similarity NPC249791
0.875 High Similarity NPC474565
0.874 High Similarity NPC239302
0.8739 High Similarity NPC275519
0.8739 High Similarity NPC212743
0.873 High Similarity NPC244246
0.873 High Similarity NPC311419
0.873 High Similarity NPC123196
0.873 High Similarity NPC65935
0.873 High Similarity NPC215941
0.873 High Similarity NPC319282
0.873 High Similarity NPC137427
0.873 High Similarity NPC275724
0.8707 High Similarity NPC51698
0.8699 High Similarity NPC74478
0.8678 High Similarity NPC471877
0.8678 High Similarity NPC166759
0.8678 High Similarity NPC470848
0.8678 High Similarity NPC470849
0.8672 High Similarity NPC36490
0.8672 High Similarity NPC327410
0.8667 High Similarity NPC24474
0.8667 High Similarity NPC311595
0.8667 High Similarity NPC299406
0.8667 High Similarity NPC37858
0.8667 High Similarity NPC141791
0.8667 High Similarity NPC263386
0.8655 High Similarity NPC164386
0.8629 High Similarity NPC299584
0.8629 High Similarity NPC271985
0.8629 High Similarity NPC208950
0.8629 High Similarity NPC82483
0.8629 High Similarity NPC472093
0.8629 High Similarity NPC228771
0.8629 High Similarity NPC17943
0.8629 High Similarity NPC251855
0.8629 High Similarity NPC148627
0.8629 High Similarity NPC265483
0.8629 High Similarity NPC233410
0.8629 High Similarity NPC58279
0.8629 High Similarity NPC116907
0.8629 High Similarity NPC300326
0.8629 High Similarity NPC29008
0.8629 High Similarity NPC194519
0.8629 High Similarity NPC266705
0.8629 High Similarity NPC9067
0.8629 High Similarity NPC3221
0.8629 High Similarity NPC298757
0.8629 High Similarity NPC221077
0.8629 High Similarity NPC57490
0.8629 High Similarity NPC193544
0.8629 High Similarity NPC117214
0.8629 High Similarity NPC203133
0.8629 High Similarity NPC475169
0.8626 High Similarity NPC284409
0.8621 High Similarity NPC226250
0.8618 High Similarity NPC197757
0.8618 High Similarity NPC228922
0.8615 High Similarity NPC120852
0.8615 High Similarity NPC90431
0.8607 High Similarity NPC127389
0.8607 High Similarity NPC290451
0.8594 High Similarity NPC245120
0.8583 High Similarity NPC124916
0.8583 High Similarity NPC474214
0.8583 High Similarity NPC474040
0.8571 High Similarity NPC281277
0.8571 High Similarity NPC109275
0.8561 High Similarity NPC474784
0.856 High Similarity NPC28730
0.856 High Similarity NPC17837
0.856 High Similarity NPC214406
0.856 High Similarity NPC18924
0.856 High Similarity NPC58607
0.856 High Similarity NPC274356
0.856 High Similarity NPC44748
0.856 High Similarity NPC103823
0.856 High Similarity NPC223136
0.856 High Similarity NPC304630
0.856 High Similarity NPC178284
0.856 High Similarity NPC78974
0.856 High Similarity NPC191037
0.8559 High Similarity NPC33749

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC109083 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.9741 High Similarity NPD4379 Clinical (unspecified phase)
0.9138 High Similarity NPD5536 Phase 2
0.8783 High Similarity NPD228 Approved
0.8475 Intermediate Similarity NPD5283 Phase 1
0.8359 Intermediate Similarity NPD3027 Phase 3
0.8346 Intermediate Similarity NPD9494 Approved
0.8136 Intermediate Similarity NPD3022 Approved
0.8136 Intermediate Similarity NPD3021 Approved
0.7966 Intermediate Similarity NPD1358 Approved
0.792 Intermediate Similarity NPD1357 Approved
0.7891 Intermediate Similarity NPD2983 Phase 2
0.7891 Intermediate Similarity NPD2982 Phase 2
0.7812 Intermediate Similarity NPD2981 Phase 2
0.7788 Intermediate Similarity NPD9296 Approved
0.7761 Intermediate Similarity NPD3619 Clinical (unspecified phase)
0.7761 Intermediate Similarity NPD4060 Phase 1
0.7761 Intermediate Similarity NPD3620 Phase 2
0.7744 Intermediate Similarity NPD3145 Approved
0.7744 Intermediate Similarity NPD3144 Approved
0.7731 Intermediate Similarity NPD3134 Approved
0.773 Intermediate Similarity NPD4357 Discontinued
0.7727 Intermediate Similarity NPD1529 Clinical (unspecified phase)
0.7687 Intermediate Similarity NPD2674 Phase 3
0.7681 Intermediate Similarity NPD7266 Discontinued
0.7652 Intermediate Similarity NPD3018 Phase 2
0.7652 Intermediate Similarity NPD1530 Clinical (unspecified phase)
0.7635 Intermediate Similarity NPD3882 Suspended
0.763 Intermediate Similarity NPD1613 Approved
0.763 Intermediate Similarity NPD1612 Clinical (unspecified phase)
0.763 Intermediate Similarity NPD1558 Phase 1
0.7619 Intermediate Similarity NPD2801 Approved
0.7615 Intermediate Similarity NPD3600 Clinical (unspecified phase)
0.7606 Intermediate Similarity NPD6143 Clinical (unspecified phase)
0.7603 Intermediate Similarity NPD2684 Approved
0.7578 Intermediate Similarity NPD4626 Approved
0.7551 Intermediate Similarity NPD1934 Approved
0.7537 Intermediate Similarity NPD7095 Approved
0.75 Intermediate Similarity NPD7843 Approved
0.7482 Intermediate Similarity NPD2935 Discontinued
0.7478 Intermediate Similarity NPD2934 Approved
0.7478 Intermediate Similarity NPD2933 Approved
0.746 Intermediate Similarity NPD7157 Approved
0.7447 Intermediate Similarity NPD3060 Approved
0.7438 Intermediate Similarity NPD968 Approved
0.7424 Intermediate Similarity NPD2922 Phase 1
0.7414 Intermediate Similarity NPD2860 Approved
0.7414 Intermediate Similarity NPD2859 Approved
0.7397 Intermediate Similarity NPD1653 Approved
0.7394 Intermediate Similarity NPD8166 Discontinued
0.7385 Intermediate Similarity NPD3847 Discontinued
0.7385 Intermediate Similarity NPD3496 Discontinued
0.7383 Intermediate Similarity NPD2393 Clinical (unspecified phase)
0.7373 Intermediate Similarity NPD3020 Approved
0.7364 Intermediate Similarity NPD1651 Approved
0.7361 Intermediate Similarity NPD1511 Approved
0.736 Intermediate Similarity NPD5535 Approved
0.7353 Intermediate Similarity NPD5111 Phase 2
0.7353 Intermediate Similarity NPD5110 Phase 2
0.7353 Intermediate Similarity NPD5109 Approved
0.7343 Intermediate Similarity NPD6190 Approved
0.7333 Intermediate Similarity NPD5752 Clinical (unspecified phase)
0.7328 Intermediate Similarity NPD3705 Approved
0.7323 Intermediate Similarity NPD6671 Approved
0.7319 Intermediate Similarity NPD447 Suspended
0.7313 Intermediate Similarity NPD6584 Phase 3
0.7302 Intermediate Similarity NPD1241 Discontinued
0.7273 Intermediate Similarity NPD4110 Phase 3
0.7273 Intermediate Similarity NPD4628 Phase 3
0.7273 Intermediate Similarity NPD3972 Approved
0.7273 Intermediate Similarity NPD4109 Clinical (unspecified phase)
0.7266 Intermediate Similarity NPD2492 Phase 1
0.726 Intermediate Similarity NPD1512 Approved
0.7258 Intermediate Similarity NPD5451 Approved
0.725 Intermediate Similarity NPD291 Approved
0.7236 Intermediate Similarity NPD290 Approved
0.7231 Intermediate Similarity NPD5691 Approved
0.723 Intermediate Similarity NPD3866 Clinical (unspecified phase)
0.723 Intermediate Similarity NPD3455 Phase 2
0.723 Intermediate Similarity NPD824 Approved
0.7226 Intermediate Similarity NPD6798 Discontinued
0.7226 Intermediate Similarity NPD5718 Phase 2
0.7211 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.7203 Intermediate Similarity NPD4162 Approved
0.7194 Intermediate Similarity NPD4340 Discontinued
0.7194 Intermediate Similarity NPD6355 Discontinued
0.7194 Intermediate Similarity NPD230 Phase 1
0.7181 Intermediate Similarity NPD7028 Phase 2
0.7179 Intermediate Similarity NPD6167 Clinical (unspecified phase)
0.7179 Intermediate Similarity NPD6168 Clinical (unspecified phase)
0.7179 Intermediate Similarity NPD6166 Phase 2
0.7176 Intermediate Similarity NPD6516 Phase 2
0.7176 Intermediate Similarity NPD5846 Approved
0.7174 Intermediate Similarity NPD4062 Phase 3
0.7174 Intermediate Similarity NPD6233 Phase 2
0.7171 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.7167 Intermediate Similarity NPD1242 Phase 1
0.7164 Intermediate Similarity NPD1283 Approved
0.7164 Intermediate Similarity NPD1876 Approved
0.7132 Intermediate Similarity NPD2861 Phase 2
0.7122 Intermediate Similarity NPD943 Approved
0.7122 Intermediate Similarity NPD1240 Approved
0.7105 Intermediate Similarity NPD3817 Phase 2
0.7103 Intermediate Similarity NPD5241 Discontinued
0.7099 Intermediate Similarity NPD5585 Approved
0.7092 Intermediate Similarity NPD6896 Approved
0.7092 Intermediate Similarity NPD6895 Approved
0.709 Intermediate Similarity NPD6582 Phase 2
0.709 Intermediate Similarity NPD6583 Phase 3
0.7089 Intermediate Similarity NPD3818 Discontinued
0.7083 Intermediate Similarity NPD4237 Approved
0.7083 Intermediate Similarity NPD4236 Phase 3
0.708 Intermediate Similarity NPD4908 Phase 1
0.7075 Intermediate Similarity NPD4123 Phase 3
0.7071 Intermediate Similarity NPD1933 Approved
0.7068 Intermediate Similarity NPD422 Phase 1
0.7068 Intermediate Similarity NPD1535 Discovery
0.7063 Intermediate Similarity NPD3540 Phase 1
0.7059 Intermediate Similarity NPD2798 Approved
0.705 Intermediate Similarity NPD1726 Clinical (unspecified phase)
0.7045 Intermediate Similarity NPD2423 Clinical (unspecified phase)
0.7045 Intermediate Similarity NPD2668 Approved
0.7045 Intermediate Similarity NPD2667 Approved
0.7044 Intermediate Similarity NPD7054 Approved
0.7042 Intermediate Similarity NPD1510 Phase 2
0.7042 Intermediate Similarity NPD2799 Discontinued
0.7039 Intermediate Similarity NPD2977 Approved
0.7039 Intermediate Similarity NPD2978 Approved
0.7034 Intermediate Similarity NPD6331 Phase 2
0.7023 Intermediate Similarity NPD1548 Phase 1
0.7023 Intermediate Similarity NPD1894 Discontinued
0.7021 Intermediate Similarity NPD1607 Approved
0.7015 Intermediate Similarity NPD2233 Approved
0.7015 Intermediate Similarity NPD2232 Approved
0.7015 Intermediate Similarity NPD1481 Phase 2
0.7015 Intermediate Similarity NPD2230 Approved
0.7014 Intermediate Similarity NPD2424 Discontinued
0.7007 Intermediate Similarity NPD5297 Approved
0.7 Intermediate Similarity NPD7074 Phase 3
0.7 Intermediate Similarity NPD7472 Approved
0.6993 Remote Similarity NPD3539 Phase 1
0.6991 Remote Similarity NPD111 Approved
0.6987 Remote Similarity NPD2821 Approved
0.6986 Remote Similarity NPD2219 Phase 1
0.6985 Remote Similarity NPD2797 Approved
0.6985 Remote Similarity NPD3053 Approved
0.6985 Remote Similarity NPD1203 Approved
0.6985 Remote Similarity NPD3055 Approved
0.6978 Remote Similarity NPD4907 Clinical (unspecified phase)
0.6978 Remote Similarity NPD3268 Approved
0.6968 Remote Similarity NPD6234 Discontinued
0.6966 Remote Similarity NPD5177 Phase 3
0.6966 Remote Similarity NPD7421 Clinical (unspecified phase)
0.6963 Remote Similarity NPD1669 Approved
0.6962 Remote Similarity NPD2898 Approved
0.6954 Remote Similarity NPD4380 Phase 2
0.6953 Remote Similarity NPD821 Approved
0.6953 Remote Similarity NPD9379 Approved
0.6953 Remote Similarity NPD9377 Approved
0.695 Remote Similarity NPD3657 Discovery
0.6944 Remote Similarity NPD2344 Approved
0.6943 Remote Similarity NPD6232 Discontinued
0.694 Remote Similarity NPD1281 Approved
0.694 Remote Similarity NPD1610 Phase 2
0.6935 Remote Similarity NPD9697 Approved
0.6934 Remote Similarity NPD4624 Approved
0.6929 Remote Similarity NPD9280 Clinical (unspecified phase)
0.6923 Remote Similarity NPD6028 Clinical (unspecified phase)
0.6923 Remote Similarity NPD6029 Clinical (unspecified phase)
0.6923 Remote Similarity NPD709 Approved
0.6918 Remote Similarity NPD7473 Discontinued
0.6917 Remote Similarity NPD1778 Approved
0.6914 Remote Similarity NPD7685 Pre-registration
0.6912 Remote Similarity NPD5311 Approved
0.6912 Remote Similarity NPD5310 Approved
0.6912 Remote Similarity NPD3225 Approved
0.6908 Remote Similarity NPD6873 Phase 2
0.6908 Remote Similarity NPD6386 Approved
0.6908 Remote Similarity NPD6385 Approved
0.6901 Remote Similarity NPD6653 Approved
0.6901 Remote Similarity NPD2653 Approved
0.6897 Remote Similarity NPD4664 Clinical (unspecified phase)
0.6897 Remote Similarity NPD9295 Approved
0.6894 Remote Similarity NPD9545 Approved
0.6894 Remote Similarity NPD1182 Approved
0.6892 Remote Similarity NPD6799 Approved
0.6891 Remote Similarity NPD1432 Clinical (unspecified phase)
0.6889 Remote Similarity NPD1608 Approved
0.6889 Remote Similarity NPD2337 Clinical (unspecified phase)
0.6889 Remote Similarity NPD2235 Phase 2
0.6889 Remote Similarity NPD2231 Phase 2
0.6887 Remote Similarity NPD7458 Discontinued
0.6887 Remote Similarity NPD3111 Phase 1
0.6879 Remote Similarity NPD4140 Approved
0.6879 Remote Similarity NPD5837 Clinical (unspecified phase)
0.6875 Remote Similarity NPD6032 Approved
0.6875 Remote Similarity NPD2161 Phase 2
0.6871 Remote Similarity NPD2354 Approved
0.6863 Remote Similarity NPD37 Approved
0.6857 Remote Similarity NPD6859 Clinical (unspecified phase)
0.6853 Remote Similarity NPD4536 Approved

Structure

External Identifiers

PubChem CID   5281767
ChEMBL   CHEMBL116438
ZINC  

Physicochemical Properties

Molecular Weight:  368.13
ALogP:  -0.6611
MLogP:  3.11
XLogP:  2.955
# Rotatable Bonds:  12
Polar Surface Area:  96.22
# H-Bond Aceptor:  2
# H-Bond Donor:  3
# Rings:  2
# Heavy Atoms:  27

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