Natural Product: NPC208022

Natural Product ID:  NPC208022
Common Name:   2-Aminophenoxazin-3-One
IUPAC Name:   2-aminophenoxazin-3-one
Synonyms:   2-Aminophenoxazinone
Molecular Formula:   C12H8N2O2
Standard InCHIKey:  RDJXPXHQENRCNG-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C12H8N2O2/c13-7-5-9-12(6-10(7)15)16-11-4-2-1-3-8(11)14-9/h1-6H,13H2
Canonical SMILES:  O=c1cc2oc3ccccc3nc2cc1N
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO6814 Pegaeophyton scapiflorum Species Brassicaceae Eukaryota UNPD*
NPO4093 Astragalus stipulosus Species Fabaceae Eukaryota UNPD*
NPO18779 Melampodium longicorne Species Asteraceae Eukaryota UNPD*
NPO18353 Alstonia glabriflora Species Apocynaceae Eukaryota UNPD*
NPO6984 Brickellia veronicaefolia Species Asteraceae Eukaryota UNPD*
NPO18957 Senecio ambavilla Species Asteraceae Eukaryota UNPD*
NPO19862 Gentiana siphonantha Species Gentianaceae Eukaryota UNPD*
NPO695 Picea sitchensis Species Pinaceae Eukaryota UNPD*
NPO8183 Asplenium viviparum Species Aspleniaceae Eukaryota UNPD*
NPO254 Coreopsis capillacea Species Asteraceae Eukaryota UNPD*
NPO1845 Physocarpus opulifolius Species Rosaceae Eukaryota UNPD*
NPO12143 Corydalis solida Species Papaveraceae Eukaryota UNPD*
NPO19737 Naucleopsis macrophylla Species Moraceae Eukaryota UNPD*
NPO3712 Pedicularis olgae Species Orobanchaceae Eukaryota UNPD*
NPO19596 Drepanocarpus lunatus NA NA NA UNPD*
NPO4124 Dimocarpus longan Species Sapindaceae Eukaryota UNPD*
NPO6636 Ophiorrhiza filistipula Species Rubiaceae Eukaryota UNPD*
NPO2531 Daniellia oliveri Species Fabaceae Eukaryota UNPD*
NPO5089 Abies forrestii Species Pinaceae Eukaryota UNPD*
NPO22810 Streptomyces Species Streptomycetaceae Bacteria StreptomeDB*
NPO21195 Ilex warburgii Species Aquifoliaceae Eukaryota UNPD*
NPO21517 Lychnophora salicifolia Species Asteraceae Eukaryota UNPD*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT404 Cell Line CCRF-CEM Homo sapiens IC50 = 2000 nM 12431048
NPT4474 Cell Line CCRF-SB Homo sapiens IC50 = 1000 nM 12431048
NPT25 Cell Line MT4 Homo sapiens IC50 = 1200 nM 12431048
NPT165 Cell Line HeLa Homo sapiens IC50 = 2700 nM 12431048
NPT1171 Cell Line HEp-2 Homo sapiens IC50 = 1800 nM 12431048
NPT2 Others Unspecified GI50 = 4450 nM 16933866
NPT2 Others Unspecified TGI = 10000 nM 16933866
NPT2 Others Unspecified GI50 = 6600 nM 16933866
NPT2 Others Unspecified TGI = 26000 nM 16933866
NPT2 Others Unspecified GI50 = 610 nM 16933866
NPT2 Others Unspecified TGI = 2000 nM 16933866
NPT197 Protein-Protein Interaction Menin/Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 28183.8 nM PubChem BioAssay data set
NPT47 Individual Protein ATP-dependent DNA helicase Q1 Homo sapiens Potency = 39810.7 nM PubChem BioAssay data set
NPT48 Individual Protein Lysine-specific demethylase 4D-like Homo sapiens Potency = 12589.3 nM PubChem BioAssay data set
NPT1224 Individual Protein Glyceraldehyde-3-phosphate dehydrogenase liver Homo sapiens Potency = 100000 nM PubChem BioAssay data set
NPT1038 Individual Protein Histone-lysine N-methyltransferase MLL Homo sapiens Potency = 31622.8 nM PubChem BioAssay data set
NPT537 Individual Protein Ras-related protein Rab-9A Homo sapiens Potency = 4466.8 nM PubChem BioAssay data set
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 8912.5 nM PubChem BioAssay data set
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 7079.5 nM PubChem BioAssay data set
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 22387.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 29092.9 nM PubChem BioAssay data set
NPT3 Individual Protein Thioredoxin glutathione reductase Schistosoma mansoni Potency = 15848.9 nM PubChem BioAssay data set
NPT53 Individual Protein 4'-phosphopantetheinyl transferase ffp Bacillus subtilis Potency = 22387.2 nM PubChem BioAssay data set
NPT2 Others Unspecified IC50 = 368 nM PubChem BioAssay data set
NPT54 Individual Protein Nonstructural protein 1 Influenza A virus Potency = 31622.8 nM PubChem BioAssay data set
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 11220.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency = 22387.2 nM PubChem BioAssay data set
NPT55 Individual Protein Putative fructose-1,6-bisphosphate aldolase Giardia intestinalis Potency = 19952.6 nM PubChem BioAssay data set
NPT55 Individual Protein Putative fructose-1,6-bisphosphate aldolase Giardia intestinalis Potency = 17740.7 nM PubChem BioAssay data set
NPT864 Individual Protein Lethal(3)malignant brain tumor-like protein 1 Homo sapiens Potency = 15848.9 nM PubChem BioAssay data set
NPT59 Individual Protein DNA polymerase beta Homo sapiens Potency = 25118.9 nM PubChem BioAssay data set
NPT532 Individual Protein Lysine-specific demethylase 4A Homo sapiens Potency 56234.1 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 29092.9 nM PubChem BioAssay data set
NPT152 Individual Protein Nuclear factor erythroid 2-related factor 2 Homo sapiens Potency 29092.9 nM PubChem BioAssay data set
NPT798 Individual Protein Alkaline phosphatase placental-like Homo sapiens EC50 = 57200 nM PubChem BioAssay data set
NPT801 Individual Protein Intestinal alkaline phosphatase Homo sapiens EC50 = 72100 nM PubChem BioAssay data set
NPT802 Individual Protein Alkaline phosphatase, tissue-nonspecific isozyme Homo sapiens EC50 = 74500 nM PubChem BioAssay data set
NPT63 Individual Protein Bromodomain adjacent to zinc finger domain protein 2B Homo sapiens Potency 44668.4 nM PubChem BioAssay data set
NPT64 Individual Protein ATPase family AAA domain-containing protein 5 Homo sapiens Potency 4107.8 nM PubChem BioAssay data set
NPT799 Individual Protein Intestinal alkaline phosphatase Mus musculus EC50 64100 nM PubChem BioAssay data set
NPT198 Individual Protein Vitamin D receptor Homo sapiens Potency 56234.1 nM PubChem BioAssay data set
NPT6 Organism Plasmodium falciparum Plasmodium falciparum Potency 4653.5 nM PubChem BioAssay data set
NPT47 Individual Protein ATP-dependent DNA helicase Q1 Homo sapiens Potency 100000 nM PubChem BioAssay data set
NPT7 Individual Protein Thioredoxin reductase 1, cytoplasmic Rattus norvegicus Potency 56234.1 nM PubChem BioAssay data set
NPT803 Individual Protein Flap endonuclease 1 Homo sapiens Potency 17782.8 nM PubChem BioAssay data set
NPT8 Individual Protein DNA polymerase iota Homo sapiens Potency 19952.6 nM PubChem BioAssay data set
NPT9 Individual Protein DNA polymerase eta Homo sapiens Potency 79432.8 nM PubChem BioAssay data set
NPT65 Cell Line HepG2 Homo sapiens Potency 4466.8 nM PubChem BioAssay data set
NPT199 Individual Protein DNA polymerase kappa Homo sapiens Potency 44668.4 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 10000 nM PubChem BioAssay data set
NPT154 Individual Protein Mothers against decapentaplegic homolog 3 Homo sapiens Potency 3548.1 nM PubChem BioAssay data set
NPT484 Individual Protein Luciferin 4-monooxygenase Photinus pyralis Potency 21331.3 nM PubChem BioAssay data set
NPT2971 Individual Protein DNA dC->dU-editing enzyme APOBEC-3F Homo sapiens Potency 31622.8 nM PubChem BioAssay data set
NPT10 Individual Protein Geminin Homo sapiens Potency 29092.9 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 28183.8 nM PubChem BioAssay data set
NPT477 Individual Protein DNA dC->dU-editing enzyme APOBEC-3G Homo sapiens Potency 17782.8 nM PubChem BioAssay data set
NPT10 Individual Protein Geminin Homo sapiens Potency 6513.1 nM PubChem BioAssay data set
NPT478 Individual Protein Ataxin-2 Homo sapiens Potency 35481.3 nM PubChem BioAssay data set
NPT755 Individual Protein Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Homo sapiens Potency 35481.3 nM PubChem BioAssay data set
NPT159 Individual Protein Aberrant vpr protein Human immunodeficiency virus 1 Potency 63095.7 nM PubChem BioAssay data set
NPT1043 Individual Protein Glycoprotein hormones alpha chain Homo sapiens Potency 28183.8 nM PubChem BioAssay data set
NPT1078 Individual Protein Indoleamine 2,3-dioxygenase Homo sapiens Inhibition = 74 % 23521768
NPT1078 Individual Protein Indoleamine 2,3-dioxygenase Homo sapiens Inhibition = 94 % 23521768
NPT1078 Individual Protein Indoleamine 2,3-dioxygenase Homo sapiens Inhibition = 82 % 23521768
NPT2 Others Unspecified Potency 1835.6 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 2059.6 nM PubChem BioAssay data set
NPT861 Individual Protein Isocitrate dehydrogenase [NADP] cytoplasmic Homo sapiens Potency 20596.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 22387.2 nM PubChem BioAssay data set
NPT105 Individual Protein Muscleblind-like protein 1 Homo sapiens Potency 12589.3 nM PubChem BioAssay data set

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC208022 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9606 High Similarity NPC297584
0.8321 Intermediate Similarity NPC315632
0.8188 Intermediate Similarity NPC231862
0.8133 Intermediate Similarity NPC57105
0.7974 Intermediate Similarity NPC314861
0.7956 Intermediate Similarity NPC473987
0.7742 Intermediate Similarity NPC127362
0.7625 Intermediate Similarity NPC315631
0.7562 Intermediate Similarity NPC8467
0.7481 Intermediate Similarity NPC264782
0.7349 Intermediate Similarity NPC313886
0.7333 Intermediate Similarity NPC473769
0.7329 Intermediate Similarity NPC476475
0.7267 Intermediate Similarity NPC473874
0.7176 Intermediate Similarity NPC255721
0.7168 Intermediate Similarity NPC108847
0.707 Intermediate Similarity NPC112766
0.7067 Intermediate Similarity NPC476462
0.7047 Intermediate Similarity NPC47986
0.7025 Intermediate Similarity NPC70549
0.6992 Remote Similarity NPC226914
0.6974 Remote Similarity NPC260601
0.6966 Remote Similarity NPC214368
0.6797 Remote Similarity NPC168750
0.6767 Remote Similarity NPC76327
0.6718 Remote Similarity NPC311660
0.6667 Remote Similarity NPC29650
0.6623 Remote Similarity NPC138365
0.6618 Remote Similarity NPC9336
0.659 Remote Similarity NPC469829
0.6577 Remote Similarity NPC313466
0.6558 Remote Similarity NPC314113
0.6529 Remote Similarity NPC286195
0.6524 Remote Similarity NPC306366
0.6474 Remote Similarity NPC118776
0.6454 Remote Similarity NPC258992
0.6453 Remote Similarity NPC316161
0.6429 Remote Similarity NPC1527
0.6405 Remote Similarity NPC122542
0.6364 Remote Similarity NPC301163
0.6347 Remote Similarity NPC118511
0.6343 Remote Similarity NPC469831
0.6341 Remote Similarity NPC315257
0.6337 Remote Similarity NPC473432
0.6316 Remote Similarity NPC70201
0.631 Remote Similarity NPC204179
0.6299 Remote Similarity NPC13826
0.6299 Remote Similarity NPC209195
0.6291 Remote Similarity NPC196026
0.6291 Remote Similarity NPC200555
0.6278 Remote Similarity NPC475411
0.6257 Remote Similarity NPC110741
0.6242 Remote Similarity NPC10875
0.6242 Remote Similarity NPC10730
0.6234 Remote Similarity NPC274441
0.6228 Remote Similarity NPC93653
0.6228 Remote Similarity NPC19023
0.6221 Remote Similarity NPC73280
0.6201 Remote Similarity NPC469830
0.6199 Remote Similarity NPC477888
0.6196 Remote Similarity NPC478049
0.619 Remote Similarity NPC257763
0.6186 Remote Similarity NPC314817
0.6186 Remote Similarity NPC66191
0.6186 Remote Similarity NPC316297
0.6184 Remote Similarity NPC231382
0.6176 Remote Similarity NPC256838
0.6169 Remote Similarity NPC105541
0.6169 Remote Similarity NPC91615
0.6165 Remote Similarity NPC313918
0.6164 Remote Similarity NPC263835
0.6141 Remote Similarity NPC470023
0.6133 Remote Similarity NPC250476
0.6125 Remote Similarity NPC473804
0.6118 Remote Similarity NPC299582
0.6111 Remote Similarity NPC315829
0.6111 Remote Similarity NPC125306
0.6108 Remote Similarity NPC470021
0.6108 Remote Similarity NPC314948
0.6104 Remote Similarity NPC471953
0.6096 Remote Similarity NPC256369
0.6087 Remote Similarity NPC119569
0.6066 Remote Similarity NPC469961
0.6064 Remote Similarity NPC470586
0.6057 Remote Similarity NPC290069
0.6049 Remote Similarity NPC9373
0.6036 Remote Similarity NPC285635
0.6033 Remote Similarity NPC475190
0.6024 Remote Similarity NPC26872
0.6023 Remote Similarity NPC220560
0.6022 Remote Similarity NPC232872
0.6014 Remote Similarity NPC139891
0.6013 Remote Similarity NPC469828
0.6013 Remote Similarity NPC471316
0.6012 Remote Similarity NPC26850
0.6011 Remote Similarity NPC472163
0.6011 Remote Similarity NPC270301
0.6 Remote Similarity NPC177404
0.6 Remote Similarity NPC470392
0.5988 Remote Similarity NPC471652
0.5986 Remote Similarity NPC321869
0.5969 Remote Similarity NPC473422
0.5966 Remote Similarity NPC288943
0.5964 Remote Similarity NPC219383
0.5962 Remote Similarity NPC169766
0.5959 Remote Similarity NPC323948
0.5957 Remote Similarity NPC220408
0.5955 Remote Similarity NPC283810
0.5955 Remote Similarity NPC70092
0.5946 Remote Similarity NPC17388
0.5946 Remote Similarity NPC289330
0.5946 Remote Similarity NPC160120
0.5946 Remote Similarity NPC53596
0.5946 Remote Similarity NPC471308
0.5938 Remote Similarity NPC212850
0.5938 Remote Similarity NPC189724
0.5938 Remote Similarity NPC83289
0.5933 Remote Similarity NPC471315
0.5933 Remote Similarity NPC471314
0.5932 Remote Similarity NPC474902
0.5931 Remote Similarity NPC303370
0.5929 Remote Similarity NPC44836
0.5926 Remote Similarity NPC175298
0.5922 Remote Similarity NPC28368
0.5915 Remote Similarity NPC95977
0.5912 Remote Similarity NPC42591
0.5903 Remote Similarity NPC26524
0.5903 Remote Similarity NPC322735
0.5902 Remote Similarity NPC242928
0.5899 Remote Similarity NPC128730
0.5897 Remote Similarity NPC274732
0.5894 Remote Similarity NPC211218
0.589 Remote Similarity NPC247298
0.5886 Remote Similarity NPC258773
0.5886 Remote Similarity NPC471604
0.5886 Remote Similarity NPC471648
0.5882 Remote Similarity NPC103250
0.5876 Remote Similarity NPC287208
0.5875 Remote Similarity NPC314252
0.5862 Remote Similarity NPC329190
0.586 Remote Similarity NPC230403
0.5857 Remote Similarity NPC41594
0.5857 Remote Similarity NPC176971
0.5855 Remote Similarity NPC325013
0.5845 Remote Similarity NPC149545
0.5844 Remote Similarity NPC122235
0.5843 Remote Similarity NPC9475
0.5843 Remote Similarity NPC241392
0.5843 Remote Similarity NPC470019
0.5839 Remote Similarity NPC41801
0.5833 Remote Similarity NPC318429
0.5833 Remote Similarity NPC161887
0.5833 Remote Similarity NPC197335
0.5833 Remote Similarity NPC474798
0.5828 Remote Similarity NPC323798
0.5827 Remote Similarity NPC109637
0.5822 Remote Similarity NPC222982
0.5818 Remote Similarity NPC245974
0.5817 Remote Similarity NPC476249
0.5816 Remote Similarity NPC157473
0.5816 Remote Similarity NPC151530
0.5814 Remote Similarity NPC79911
0.5813 Remote Similarity NPC319645
0.5811 Remote Similarity NPC32298
0.5808 Remote Similarity NPC476287
0.5804 Remote Similarity NPC329358
0.5801 Remote Similarity NPC176127
0.5801 Remote Similarity NPC314659
0.5799 Remote Similarity NPC476580
0.5793 Remote Similarity NPC90903
0.5792 Remote Similarity NPC87391
0.5792 Remote Similarity NPC262725
0.5789 Remote Similarity NPC226794
0.5787 Remote Similarity NPC168153
0.5787 Remote Similarity NPC187501
0.5786 Remote Similarity NPC42383
0.5783 Remote Similarity NPC257142
0.5781 Remote Similarity NPC295898
0.5778 Remote Similarity NPC85613
0.5778 Remote Similarity NPC5167
0.5776 Remote Similarity NPC181526
0.5776 Remote Similarity NPC160747
0.5775 Remote Similarity NPC97811
0.5775 Remote Similarity NPC146530
0.5773 Remote Similarity NPC471736
0.5772 Remote Similarity NPC43435
0.5772 Remote Similarity NPC54243
0.5772 Remote Similarity NPC43275
0.5769 Remote Similarity NPC84478
0.5767 Remote Similarity NPC308197
0.5766 Remote Similarity NPC132725
0.5766 Remote Similarity NPC307039
0.5765 Remote Similarity NPC56635
0.5764 Remote Similarity NPC166837
0.5761 Remote Similarity NPC66083
0.5756 Remote Similarity NPC120798
0.5756 Remote Similarity NPC235628
0.5755 Remote Similarity NPC179686
0.5754 Remote Similarity NPC283152
0.5753 Remote Similarity NPC87563

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC208022 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7652 Intermediate Similarity NPD254 Approved
0.7535 Intermediate Similarity NPD1393 Approved
0.7403 Intermediate Similarity NPD980 Clinical (unspecified phase)
0.7329 Intermediate Similarity NPD204 Clinical (unspecified phase)
0.723 Intermediate Similarity NPD7083 Clinical (unspecified phase)
0.7172 Intermediate Similarity NPD756 Suspended
0.7152 Intermediate Similarity NPD1012 Discontinued
0.7047 Intermediate Similarity NPD1422 Approved
0.7007 Intermediate Similarity NPD9694 Discovery
0.6962 Remote Similarity NPD3778 Approved
0.6908 Remote Similarity NPD965 Approved
0.6867 Remote Similarity NPD2525 Clinical (unspecified phase)
0.6861 Remote Similarity NPD9342 Approved
0.6855 Remote Similarity NPD4205 Phase 3
0.6815 Remote Similarity NPD8330 Clinical (unspecified phase)
0.6774 Remote Similarity NPD1084 Clinical (unspecified phase)
0.6774 Remote Similarity NPD1305 Clinical (unspecified phase)
0.6767 Remote Similarity NPD9507 Approved
0.6746 Remote Similarity NPD3580 Discontinued
0.6735 Remote Similarity NPD1314 Clinical (unspecified phase)
0.673 Remote Similarity NPD789 Phase 2
0.6726 Remote Similarity NPD4020 Clinical (unspecified phase)
0.6667 Remote Similarity NPD1559 Discontinued
0.6667 Remote Similarity NPD2842 Clinical (unspecified phase)
0.6646 Remote Similarity NPD4201 Clinical (unspecified phase)
0.6646 Remote Similarity NPD2366 Approved
0.6645 Remote Similarity NPD822 Approved
0.6627 Remote Similarity NPD2680 Approved
0.6627 Remote Similarity NPD2681 Approved
0.6627 Remote Similarity NPD2247 Approved
0.6627 Remote Similarity NPD2249 Approved
0.6566 Remote Similarity NPD4943 Phase 2
0.6566 Remote Similarity NPD4944 Phase 2
0.6531 Remote Similarity NPD850 Approved
0.6531 Remote Similarity NPD849 Approved
0.6531 Remote Similarity NPD848 Approved
0.6519 Remote Similarity NPD2752 Clinical (unspecified phase)
0.6516 Remote Similarity NPD5719 Approved
0.6491 Remote Similarity NPD3965 Phase 1
0.6486 Remote Similarity NPD4993 Discontinued
0.6483 Remote Similarity NPD522 Approved
0.6463 Remote Similarity NPD6060 Clinical (unspecified phase)
0.646 Remote Similarity NPD4003 Phase 3
0.6452 Remote Similarity NPD9245 Clinical (unspecified phase)
0.6441 Remote Similarity NPD1898 Discontinued
0.6429 Remote Similarity NPD5788 Clinical (unspecified phase)
0.6425 Remote Similarity NPD4324 Phase 2
0.6425 Remote Similarity NPD4325 Phase 2
0.642 Remote Similarity NPD5811 Approved
0.6419 Remote Similarity NPD1160 Phase 2
0.6412 Remote Similarity NPD3951 Phase 3
0.6412 Remote Similarity NPD3952 Approved
0.6412 Remote Similarity NPD3953 Clinical (unspecified phase)
0.641 Remote Similarity NPD4597 Approved
0.641 Remote Similarity NPD4598 Approved
0.6402 Remote Similarity NPD1769 Discontinued
0.6398 Remote Similarity NPD3627 Approved
0.6384 Remote Similarity NPD6393 Clinical (unspecified phase)
0.6382 Remote Similarity NPD3463 Discontinued
0.638 Remote Similarity NPD1557 Discontinued
0.638 Remote Similarity NPD3296 Phase 1
0.6369 Remote Similarity NPD2341 Discontinued
0.6359 Remote Similarity NPD2339 Phase 3
0.6353 Remote Similarity NPD2216 Approved
0.6353 Remote Similarity NPD2215 Approved
0.6348 Remote Similarity NPD7326 Phase 3
0.6341 Remote Similarity NPD4255 Phase 1
0.6337 Remote Similarity NPD4354 Approved
0.6329 Remote Similarity NPD2086 Clinical (unspecified phase)
0.6329 Remote Similarity NPD5481 Discontinued
0.6329 Remote Similarity NPD2085 Suspended
0.6327 Remote Similarity NPD4129 Approved
0.6327 Remote Similarity NPD1158 Phase 2
0.6322 Remote Similarity NPD6654 Clinical (unspecified phase)
0.6316 Remote Similarity NPD5078 Clinical (unspecified phase)
0.6312 Remote Similarity NPD2114 Discontinued
0.6303 Remote Similarity NPD7317 Phase 3
0.6302 Remote Similarity NPD3945 Discontinued
0.6294 Remote Similarity NPD4606 Clinical (unspecified phase)
0.6273 Remote Similarity NPD2335 Discontinued
0.6265 Remote Similarity NPD5294 Clinical (unspecified phase)
0.6258 Remote Similarity NPD2883 Discontinued
0.625 Remote Similarity NPD1891 Discontinued
0.6242 Remote Similarity NPD3567 Approved
0.6242 Remote Similarity NPD3237 Clinical (unspecified phase)
0.6242 Remote Similarity NPD3236 Phase 3
0.6242 Remote Similarity NPD3568 Approved
0.6237 Remote Similarity NPD7566 Clinical (unspecified phase)
0.6236 Remote Similarity NPD3154 Approved
0.6236 Remote Similarity NPD3153 Approved
0.6228 Remote Similarity NPD3559 Clinical (unspecified phase)
0.6228 Remote Similarity NPD3558 Approved
0.6228 Remote Similarity NPD3556 Approved
0.6228 Remote Similarity NPD3560 Approved
0.6228 Remote Similarity NPD3557 Approved
0.6228 Remote Similarity NPD7318 Phase 3
0.6226 Remote Similarity NPD2241 Approved
0.6222 Remote Similarity NPD6136 Phase 2
0.6221 Remote Similarity NPD2248 Approved
0.6221 Remote Similarity NPD2246 Approved
0.6215 Remote Similarity NPD1334 Clinical (unspecified phase)
0.6215 Remote Similarity NPD2374 Approved
0.6205 Remote Similarity NPD3812 Clinical (unspecified phase)
0.6201 Remote Similarity NPD4515 Suspended
0.6199 Remote Similarity NPD5847 Phase 1
0.6199 Remote Similarity NPD565 Phase 2
0.6196 Remote Similarity NPD4604 Approved
0.6196 Remote Similarity NPD4605 Approved
0.6193 Remote Similarity NPD6104 Discontinued
0.619 Remote Similarity NPD1191 Discontinued
0.6176 Remote Similarity NPD2162 Clinical (unspecified phase)
0.6171 Remote Similarity NPD2827 Approved
0.6171 Remote Similarity NPD2826 Approved
0.6171 Remote Similarity NPD2825 Approved
0.6167 Remote Similarity NPD2542 Clinical (unspecified phase)
0.6162 Remote Similarity NPD772 Phase 3
0.6159 Remote Similarity NPD5267 Discontinued
0.6159 Remote Similarity NPD9624 Approved
0.6154 Remote Similarity NPD4302 Clinical (unspecified phase)
0.6154 Remote Similarity NPD3453 Discontinued
0.6154 Remote Similarity NPD955 Approved
0.6149 Remote Similarity NPD5132 Clinical (unspecified phase)
0.6149 Remote Similarity NPD5603 Clinical (unspecified phase)
0.6146 Remote Similarity NPD1166 Clinical (unspecified phase)
0.6145 Remote Similarity NPD6638 Approved
0.614 Remote Similarity NPD2821 Approved
0.6139 Remote Similarity NPD521 Clinical (unspecified phase)
0.6139 Remote Similarity NPD7753 Approved
0.6139 Remote Similarity NPD7752 Approved
0.6136 Remote Similarity NPD6293 Clinical (unspecified phase)
0.6135 Remote Similarity NPD9509 Clinical (unspecified phase)
0.6135 Remote Similarity NPD4186 Clinical (unspecified phase)
0.6131 Remote Similarity NPD6063 Approved
0.6129 Remote Similarity NPD5547 Clinical (unspecified phase)
0.6127 Remote Similarity NPD6607 Clinical (unspecified phase)
0.6127 Remote Similarity NPD5858 Discontinued
0.6121 Remote Similarity NPD2312 Discontinued
0.6117 Remote Similarity NPD6511 Phase 1
0.6117 Remote Similarity NPD6510 Phase 1
0.6115 Remote Similarity NPD3260 Discontinued
0.6108 Remote Similarity NPD3312 Phase 1
0.6108 Remote Similarity NPD3311 Phase 1
0.6108 Remote Similarity NPD9574 Clinical (unspecified phase)
0.6104 Remote Similarity NPD7477 Discontinued
0.6096 Remote Similarity NPD2595 Approved
0.6096 Remote Similarity NPD2594 Approved
0.6089 Remote Similarity NPD6045 Phase 3
0.6084 Remote Similarity NPD3684 Discontinued
0.6084 Remote Similarity NPD3538 Suspended
0.6082 Remote Similarity NPD3251 Approved
0.608 Remote Similarity NPD2425 Phase 1
0.6074 Remote Similarity NPD7499 Phase 1
0.6074 Remote Similarity NPD7498 Phase 1
0.6073 Remote Similarity NPD7043 Discontinued
0.6066 Remote Similarity NPD9243 Approved
0.6061 Remote Similarity NPD1678 Clinical (unspecified phase)
0.6061 Remote Similarity NPD950 Clinical (unspecified phase)
0.6056 Remote Similarity NPD3316 Clinical (unspecified phase)
0.6054 Remote Similarity NPD8249 Clinical (unspecified phase)
0.6053 Remote Similarity NPD5266 Clinical (unspecified phase)
0.6047 Remote Similarity NPD7126 Discontinued
0.6047 Remote Similarity NPD4986 Clinical (unspecified phase)
0.6047 Remote Similarity NPD6379 Discontinued
0.6044 Remote Similarity NPD6880 Phase 3
0.6043 Remote Similarity NPD5373 Approved
0.6043 Remote Similarity NPD5374 Approved
0.6043 Remote Similarity NPD6757 Phase 3
0.6038 Remote Similarity NPD3656 Approved
0.6036 Remote Similarity NPD2358 Clinical (unspecified phase)
0.6034 Remote Similarity NPD5083 Clinical (unspecified phase)
0.6034 Remote Similarity NPD7546 Discontinued
0.6031 Remote Similarity NPD7468 Clinical (unspecified phase)
0.6028 Remote Similarity NPD9376 Approved
0.6026 Remote Similarity NPD3827 Clinical (unspecified phase)
0.6026 Remote Similarity NPD654 Phase 3
0.6023 Remote Similarity NPD5521 Clinical (unspecified phase)
0.6022 Remote Similarity NPD4979 Clinical (unspecified phase)
0.6014 Remote Similarity NPD9697 Approved
0.6013 Remote Similarity NPD6380 Phase 1
0.6012 Remote Similarity NPD5183 Approved
0.6012 Remote Similarity NPD5186 Approved
0.6 Remote Similarity NPD3802 Phase 3
0.6 Remote Similarity NPD5938 Phase 3
0.6 Remote Similarity NPD3869 Phase 3
0.6 Remote Similarity NPD5602 Clinical (unspecified phase)
0.6 Remote Similarity NPD3873 Phase 3
0.6 Remote Similarity NPD7153 Discontinued
0.599 Remote Similarity NPD2433 Clinical (unspecified phase)
0.5989 Remote Similarity NPD5558 Clinical (unspecified phase)
0.5989 Remote Similarity NPD2792 Approved
0.5989 Remote Similarity NPD5900 Clinical (unspecified phase)
0.5989 Remote Similarity NPD6608 Clinical (unspecified phase)
0.5989 Remote Similarity NPD795 Clinical (unspecified phase)
0.5987 Remote Similarity NPD442 Discontinued
0.5986 Remote Similarity NPD308 Approved
0.5978 Remote Similarity NPD7288 Phase 3
0.5978 Remote Similarity NPD4372 Phase 1
0.5977 Remote Similarity NPD4083 Discontinued
0.5976 Remote Similarity NPD6737 Phase 2
0.5976 Remote Similarity NPD681 Clinical (unspecified phase)

Structure

External Identifiers

PubChem CID   72725
ChEMBL   CHEMBL146710
ZINC  

Physicochemical Properties

Molecular Weight:  212.06
ALogP:  -1.4448
MLogP:  2.34
XLogP:  2.194
# Rotatable Bonds:  1
Polar Surface Area:  64.68
# H-Bond Aceptor:  3
# H-Bond Donor:  1
# Rings:  3
# Heavy Atoms:  16

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Biological Activities  
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