Natural Product: NPC181526

Natural Product ID:  NPC181526
Common Name:   3-Amino-2-Hydroxybenzoic Acid
IUPAC Name:   3-amino-2-hydroxybenzoic acid
Synonyms:  
Molecular Formula:   C7H7NO3
Standard InCHIKey:  IQGMRVWUTCYCST-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C7H7NO3/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,9H,8H2,(H,10,11)
Canonical SMILES:  OC(=O)c1cccc(c1O)N
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO1797 Homo sapiens Species Hominidae Eukaryota urine PMID[19309105]
NPO13391.10 Streptomyces hygroscopicus subsp. limoneus Varieties Streptomycetaceae Bacteria StreptomeDB*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT568 Individual Protein Matrix metalloproteinase-2 Homo sapiens IC50 = 389000 nM 21189019
NPT270 Individual Protein Nitric oxide synthase, inducible Mus musculus Inhibition = 18 % 21189019
NPT280 Individual Protein Matrix metalloproteinase 9 Homo sapiens Inhibition = 59 % 21189019
NPT569 Individual Protein Matrix metalloproteinase 8 Homo sapiens Inhibition = 67 % 21189019
NPT43 Individual Protein Tyrosinase Agaricus bisporus Inhibition = -32 % 21189019
NPT567 Individual Protein Matrix metalloproteinase 3 Homo sapiens Inhibition = 72 % 21189019
NPT570 Individual Protein Arachidonate 5-lipoxygenase Homo sapiens Inhibition = 72 % 21189019
NPT568 Individual Protein Matrix metalloproteinase-2 Homo sapiens Inhibition = 70 % 21189019
NPT69 Individual Protein Matrix metalloproteinase-1 Homo sapiens Inhibition = 69 % 21189019
NPT150 Individual Protein Anthrax lethal factor Bacillus anthracis Inhibition = 90 % 21189019

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC181526 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9398 High Similarity NPC316574
0.8978 High Similarity NPC314252
0.8592 High Similarity NPC323798
0.8582 High Similarity NPC301702
0.8462 Intermediate Similarity NPC229353
0.8169 Intermediate Similarity NPC43218
0.7911 Intermediate Similarity NPC471778
0.7821 Intermediate Similarity NPC475983
0.7821 Intermediate Similarity NPC199737
0.7794 Intermediate Similarity NPC150323
0.7794 Intermediate Similarity NPC130931
0.7697 Intermediate Similarity NPC241392
0.7682 Intermediate Similarity NPC315829
0.7557 Intermediate Similarity NPC100551
0.7556 Intermediate Similarity NPC222982
0.7531 Intermediate Similarity NPC112336
0.7531 Intermediate Similarity NPC474814
0.7467 Intermediate Similarity NPC13696
0.7432 Intermediate Similarity NPC159722
0.7396 Intermediate Similarity NPC132751
0.7305 Intermediate Similarity NPC474815
0.7279 Intermediate Similarity NPC211421
0.7251 Intermediate Similarity NPC288854
0.7193 Intermediate Similarity NPC477391
0.7184 Intermediate Similarity NPC70340
0.7176 Intermediate Similarity NPC311660
0.7174 Intermediate Similarity NPC160179
0.7153 Intermediate Similarity NPC223004
0.7153 Intermediate Similarity NPC205946
0.7126 Intermediate Similarity NPC95412
0.7122 Intermediate Similarity NPC128825
0.7122 Intermediate Similarity NPC312800
0.7114 Intermediate Similarity NPC253476
0.7108 Intermediate Similarity NPC83241
0.7103 Intermediate Similarity NPC314278
0.7083 Intermediate Similarity NPC226794
0.7021 Intermediate Similarity NPC94637
0.7021 Intermediate Similarity NPC241089
0.7007 Intermediate Similarity NPC122235
0.6972 Remote Similarity NPC90522
0.6972 Remote Similarity NPC328459
0.6963 Remote Similarity NPC303264
0.695 Remote Similarity NPC125252
0.6948 Remote Similarity NPC43477
0.6941 Remote Similarity NPC315631
0.6936 Remote Similarity NPC315934
0.6936 Remote Similarity NPC477392
0.6928 Remote Similarity NPC181527
0.6923 Remote Similarity NPC260837
0.6923 Remote Similarity NPC233282
0.6923 Remote Similarity NPC72977
0.6913 Remote Similarity NPC314098
0.6912 Remote Similarity NPC224584
0.6883 Remote Similarity NPC238108
0.6883 Remote Similarity NPC47986
0.6883 Remote Similarity NPC242933
0.6879 Remote Similarity NPC188867
0.6879 Remote Similarity NPC281686
0.6879 Remote Similarity NPC106551
0.6875 Remote Similarity NPC264400
0.6867 Remote Similarity NPC313466
0.6853 Remote Similarity NPC233165
0.6853 Remote Similarity NPC184579
0.6835 Remote Similarity NPC146370
0.6824 Remote Similarity NPC307437
0.6824 Remote Similarity NPC72473
0.6824 Remote Similarity NPC58827
0.6807 Remote Similarity NPC204867
0.6797 Remote Similarity NPC122542
0.6767 Remote Similarity NPC70201
0.6765 Remote Similarity NPC187913
0.6759 Remote Similarity NPC301987
0.6759 Remote Similarity NPC115188
0.6759 Remote Similarity NPC292665
0.6759 Remote Similarity NPC244994
0.6759 Remote Similarity NPC26433
0.6759 Remote Similarity NPC222876
0.6759 Remote Similarity NPC179092
0.6759 Remote Similarity NPC159760
0.6759 Remote Similarity NPC272454
0.6759 Remote Similarity NPC35856
0.6759 Remote Similarity NPC178395
0.6738 Remote Similarity NPC276111
0.6738 Remote Similarity NPC118288
0.6736 Remote Similarity NPC239697
0.673 Remote Similarity NPC259678
0.6715 Remote Similarity NPC29883
0.6712 Remote Similarity NPC198336
0.6689 Remote Similarity NPC236189
0.6667 Remote Similarity NPC142638
0.6667 Remote Similarity NPC311219
0.6667 Remote Similarity NPC244351
0.6667 Remote Similarity NPC317784
0.6667 Remote Similarity NPC283844
0.6667 Remote Similarity NPC283514
0.6647 Remote Similarity NPC9475
0.6644 Remote Similarity NPC4164
0.6644 Remote Similarity NPC179468
0.6642 Remote Similarity NPC184658
0.6623 Remote Similarity NPC173295
0.6623 Remote Similarity NPC477432
0.6621 Remote Similarity NPC161617
0.662 Remote Similarity NPC163154
0.6619 Remote Similarity NPC255721
0.6608 Remote Similarity NPC126676
0.6608 Remote Similarity NPC469671
0.6605 Remote Similarity NPC144691
0.6603 Remote Similarity NPC319645
0.6603 Remote Similarity NPC238412
0.66 Remote Similarity NPC95309
0.6597 Remote Similarity NPC121259
0.6594 Remote Similarity NPC141523
0.659 Remote Similarity NPC8467
0.6577 Remote Similarity NPC265910
0.6577 Remote Similarity NPC91475
0.6573 Remote Similarity NPC188907
0.6573 Remote Similarity NPC161304
0.6573 Remote Similarity NPC240163
0.6571 Remote Similarity NPC298320
0.6571 Remote Similarity NPC98416
0.6557 Remote Similarity NPC108847
0.6556 Remote Similarity NPC71525
0.6549 Remote Similarity NPC98543
0.6544 Remote Similarity NPC13426
0.6533 Remote Similarity NPC167055
0.6533 Remote Similarity NPC240744
0.6531 Remote Similarity NPC297186
0.6531 Remote Similarity NPC165197
0.6529 Remote Similarity NPC182131
0.6528 Remote Similarity NPC108288
0.6519 Remote Similarity NPC314113
0.6513 Remote Similarity NPC95537
0.6513 Remote Similarity NPC194562
0.651 Remote Similarity NPC477153
0.6509 Remote Similarity NPC292143
0.6509 Remote Similarity NPC139506
0.6507 Remote Similarity NPC188814
0.6507 Remote Similarity NPC195262
0.6496 Remote Similarity NPC256838
0.6486 Remote Similarity NPC267552
0.6486 Remote Similarity NPC45438
0.6486 Remote Similarity NPC143427
0.6486 Remote Similarity NPC303737
0.6486 Remote Similarity NPC19174
0.6486 Remote Similarity NPC25168
0.6486 Remote Similarity NPC73532
0.6486 Remote Similarity NPC115159
0.6486 Remote Similarity NPC27581
0.6486 Remote Similarity NPC224273
0.6486 Remote Similarity NPC156139
0.6483 Remote Similarity NPC160199
0.6483 Remote Similarity NPC269414
0.6483 Remote Similarity NPC28169
0.6483 Remote Similarity NPC230349
0.6483 Remote Similarity NPC217423
0.6467 Remote Similarity NPC6888
0.6466 Remote Similarity NPC246679
0.6462 Remote Similarity NPC62765
0.6452 Remote Similarity NPC91615
0.645 Remote Similarity NPC257763
0.6447 Remote Similarity NPC181715
0.6447 Remote Similarity NPC214620
0.6443 Remote Similarity NPC133909
0.6443 Remote Similarity NPC309765
0.6443 Remote Similarity NPC297193
0.6443 Remote Similarity NPC32032
0.6438 Remote Similarity NPC273282
0.6438 Remote Similarity NPC41567
0.6438 Remote Similarity NPC209486
0.6438 Remote Similarity NPC40649
0.6438 Remote Similarity NPC474890
0.6438 Remote Similarity NPC161943
0.6438 Remote Similarity NPC184527
0.6432 Remote Similarity NPC316282
0.6429 Remote Similarity NPC42292
0.6429 Remote Similarity NPC307732
0.6429 Remote Similarity NPC31539
0.6424 Remote Similarity NPC262671
0.6424 Remote Similarity NPC201728
0.6424 Remote Similarity NPC287473
0.6419 Remote Similarity NPC326079
0.6414 Remote Similarity NPC477453
0.6414 Remote Similarity NPC83718
0.6408 Remote Similarity NPC114682
0.6397 Remote Similarity NPC52472
0.6395 Remote Similarity NPC319950
0.6391 Remote Similarity NPC27904
0.6389 Remote Similarity NPC81808
0.6387 Remote Similarity NPC198249
0.6382 Remote Similarity NPC473751
0.6382 Remote Similarity NPC321561
0.6378 Remote Similarity NPC170333
0.6377 Remote Similarity NPC38262
0.6376 Remote Similarity NPC196976
0.6376 Remote Similarity NPC242895
0.6375 Remote Similarity NPC472241
0.6374 Remote Similarity NPC144381
0.6368 Remote Similarity NPC133156
0.6364 Remote Similarity NPC317727
0.6358 Remote Similarity NPC117794

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC181526 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.9398 High Similarity NPD9279 Approved
0.8592 High Similarity NPD1196 Approved
0.8582 High Similarity NPD9277 Approved
0.8582 High Similarity NPD75 Approved
0.8521 High Similarity NPD1195 Approved
0.8511 High Similarity NPD9278 Suspended
0.8511 High Similarity NPD9276 Approved
0.8511 High Similarity NPD9274 Approved
0.8511 High Similarity NPD9275 Approved
0.8425 Intermediate Similarity NPD9509 Clinical (unspecified phase)
0.8414 Intermediate Similarity NPD1543 Discontinued
0.7914 Intermediate Similarity NPD3253 Clinical (unspecified phase)
0.7911 Intermediate Similarity NPD1839 Phase 1
0.7862 Intermediate Similarity NPD1913 Phase 1
0.7794 Intermediate Similarity NPD9272 Approved
0.7727 Intermediate Similarity NPD3684 Discontinued
0.7716 Intermediate Similarity NPD2361 Approved
0.7658 Intermediate Similarity NPD955 Approved
0.7654 Intermediate Similarity NPD2359 Approved
0.7557 Intermediate Similarity NPD74 Approved
0.7557 Intermediate Similarity NPD9266 Approved
0.7481 Intermediate Similarity NPD9267 Approved
0.7481 Intermediate Similarity NPD9264 Approved
0.7481 Intermediate Similarity NPD9263 Approved
0.7342 Intermediate Similarity NPD2366 Approved
0.7234 Intermediate Similarity NPD9693 Approved
0.7234 Intermediate Similarity NPD9692 Approved
0.7233 Intermediate Similarity NPD2672 Discontinued
0.7176 Intermediate Similarity NPD9261 Approved
0.7122 Intermediate Similarity NPD9493 Approved
0.7101 Intermediate Similarity NPD9281 Approved
0.7091 Intermediate Similarity NPD2249 Approved
0.7091 Intermediate Similarity NPD2247 Approved
0.7073 Intermediate Similarity NPD1168 Approved
0.7013 Intermediate Similarity NPD1189 Approved
0.6986 Remote Similarity NPD9567 Approved
0.6986 Remote Similarity NPD552 Approved
0.6986 Remote Similarity NPD553 Approved
0.6971 Remote Similarity NPD1898 Discontinued
0.6968 Remote Similarity NPD1625 Approved
0.6964 Remote Similarity NPD2246 Approved
0.6964 Remote Similarity NPD2248 Approved
0.6954 Remote Similarity NPD9694 Discovery
0.6948 Remote Similarity NPD9477 Approved
0.6946 Remote Similarity NPD1161 Approved
0.6929 Remote Similarity NPD256 Approved
0.6929 Remote Similarity NPD255 Approved
0.6918 Remote Similarity NPD1574 Approved
0.6884 Remote Similarity NPD9508 Approved
0.6879 Remote Similarity NPD9568 Approved
0.6864 Remote Similarity NPD1220 Phase 1
0.6821 Remote Similarity NPD520 Approved
0.6796 Remote Similarity NPD6162 Approved
0.6796 Remote Similarity NPD6161 Approved
0.6761 Remote Similarity NPD3153 Approved
0.6761 Remote Similarity NPD3154 Approved
0.6758 Remote Similarity NPD4668 Phase 2
0.6755 Remote Similarity NPD9471 Clinical (unspecified phase)
0.6744 Remote Similarity NPD1170 Approved
0.6744 Remote Similarity NPD1221 Approved
0.6724 Remote Similarity NPD6104 Discontinued
0.6715 Remote Similarity NPD9265 Clinical (unspecified phase)
0.671 Remote Similarity NPD1626 Approved
0.6686 Remote Similarity NPD2680 Approved
0.6686 Remote Similarity NPD2681 Approved
0.6667 Remote Similarity NPD9717 Approved
0.6667 Remote Similarity NPD212 Discontinued
0.6644 Remote Similarity NPD1164 Approved
0.6644 Remote Similarity NPD1203 Approved
0.6631 Remote Similarity NPD4467 Phase 2
0.6631 Remote Similarity NPD4465 Phase 2
0.6629 Remote Similarity NPD5637 Discontinued
0.6622 Remote Similarity NPD655 Approved
0.6622 Remote Similarity NPD660 Approved
0.6622 Remote Similarity NPD661 Approved
0.6622 Remote Similarity NPD657 Approved
0.6603 Remote Similarity NPD1110 Approved
0.6603 Remote Similarity NPD1109 Approved
0.6596 Remote Similarity NPD181 Approved
0.6585 Remote Similarity NPD3229 Phase 2
0.6585 Remote Similarity NPD5086 Approved
0.6568 Remote Similarity NPD3252 Approved
0.6564 Remote Similarity NPD711 Discontinued
0.6556 Remote Similarity NPD4258 Approved
0.6556 Remote Similarity NPD4259 Approved
0.6552 Remote Similarity NPD1759 Phase 1
0.6543 Remote Similarity NPD4888 Discontinued
0.6543 Remote Similarity NPD4161 Discontinued
0.6528 Remote Similarity NPD405 Clinical (unspecified phase)
0.651 Remote Similarity NPD182 Clinical (unspecified phase)
0.6497 Remote Similarity NPD3170 Approved
0.649 Remote Similarity NPD698 Approved
0.649 Remote Similarity NPD701 Approved
0.6488 Remote Similarity NPD1012 Discontinued
0.6483 Remote Similarity NPD1758 Phase 1
0.6477 Remote Similarity NPD5445 Approved
0.6464 Remote Similarity NPD5928 Phase 1
0.6463 Remote Similarity NPD1230 Approved
0.6462 Remote Similarity NPD9258 Approved
0.6462 Remote Similarity NPD9256 Approved
0.6455 Remote Similarity NPD6138 Clinical (unspecified phase)
0.6447 Remote Similarity NPD662 Approved
0.6447 Remote Similarity NPD663 Approved
0.6447 Remote Similarity NPD659 Approved
0.6447 Remote Similarity NPD656 Approved
0.6447 Remote Similarity NPD658 Approved
0.6433 Remote Similarity NPD1559 Discontinued
0.6433 Remote Similarity NPD1532 Approved
0.6433 Remote Similarity NPD6636 Phase 3
0.6433 Remote Similarity NPD3251 Approved
0.6429 Remote Similarity NPD476 Approved
0.6424 Remote Similarity NPD1593 Approved
0.642 Remote Similarity NPD3141 Discontinued
0.6395 Remote Similarity NPD2821 Approved
0.6382 Remote Similarity NPD257 Approved
0.6382 Remote Similarity NPD258 Approved
0.638 Remote Similarity NPD1340 Discontinued
0.6364 Remote Similarity NPD5609 Approved
0.6364 Remote Similarity NPD5608 Approved
0.6353 Remote Similarity NPD1210 Approved
0.6345 Remote Similarity NPD9342 Approved
0.6343 Remote Similarity NPD7324 Discontinued
0.634 Remote Similarity NPD9569 Approved
0.6335 Remote Similarity NPD6807 Phase 3
0.6333 Remote Similarity NPD6045 Phase 3
0.6323 Remote Similarity NPD411 Approved
0.631 Remote Similarity NPD5197 Approved
0.631 Remote Similarity NPD5196 Approved
0.631 Remote Similarity NPD2836 Approved
0.631 Remote Similarity NPD5194 Approved
0.6307 Remote Similarity NPD1544 Phase 1
0.6303 Remote Similarity NPD2737 Clinical (unspecified phase)
0.628 Remote Similarity NPD1801 Approved
0.628 Remote Similarity NPD1802 Approved
0.6273 Remote Similarity NPD167 Phase 2
0.6273 Remote Similarity NPD168 Phase 1
0.6272 Remote Similarity NPD3812 Clinical (unspecified phase)
0.6269 Remote Similarity NPD2514 Approved
0.6259 Remote Similarity NPD9247 Phase 3
0.625 Remote Similarity NPD9273 Approved
0.625 Remote Similarity NPD196 Phase 1
0.625 Remote Similarity NPD9570 Approved
0.625 Remote Similarity NPD5871 Discontinued
0.625 Remote Similarity NPD9587 Clinical (unspecified phase)
0.6244 Remote Similarity NPD4679 Discontinued
0.6243 Remote Similarity NPD8167 Discontinued
0.6243 Remote Similarity NPD2339 Phase 3
0.6242 Remote Similarity NPD1531 Approved
0.6241 Remote Similarity NPD9507 Approved
0.6235 Remote Similarity NPD6283 Phase 2
0.6226 Remote Similarity NPD2670 Approved
0.6222 Remote Similarity NPD1891 Discontinued
0.6216 Remote Similarity NPD9545 Approved
0.6216 Remote Similarity NPD5937 Approved
0.6211 Remote Similarity NPD7566 Clinical (unspecified phase)
0.6209 Remote Similarity NPD9540 Approved
0.6207 Remote Similarity NPD2034 Discontinued
0.6203 Remote Similarity NPD1228 Phase 2
0.6203 Remote Similarity NPD7880 Clinical (unspecified phase)
0.6203 Remote Similarity NPD447 Suspended
0.6199 Remote Similarity NPD3560 Approved
0.6199 Remote Similarity NPD3557 Approved
0.6199 Remote Similarity NPD3558 Approved
0.6199 Remote Similarity NPD3559 Clinical (unspecified phase)
0.6199 Remote Similarity NPD4311 Approved
0.6199 Remote Similarity NPD3556 Approved
0.6198 Remote Similarity NPD1294 Discontinued
0.6196 Remote Similarity NPD5819 Phase 2
0.619 Remote Similarity NPD6874 Approved
0.6188 Remote Similarity NPD1169 Approved
0.6188 Remote Similarity NPD9468 Clinical (unspecified phase)
0.618 Remote Similarity NPD5498 Phase 2
0.618 Remote Similarity NPD3965 Phase 1
0.6178 Remote Similarity NPD259 Phase 1
0.617 Remote Similarity NPD4979 Clinical (unspecified phase)
0.617 Remote Similarity NPD5195 Discontinued
0.6169 Remote Similarity NPD1019 Discontinued
0.6162 Remote Similarity NPD5076 Approved
0.6162 Remote Similarity NPD5077 Approved
0.6159 Remote Similarity NPD1201 Approved
0.6159 Remote Similarity NPD1835 Phase 1
0.6158 Remote Similarity NPD7449 Clinical (unspecified phase)
0.6154 Remote Similarity NPD3136 Phase 2
0.6154 Remote Similarity NPD9536 Phase 1
0.6154 Remote Similarity NPD9718 Approved
0.6154 Remote Similarity NPD9259 Approved
0.6154 Remote Similarity NPD9537 Phase 1
0.6154 Remote Similarity NPD9257 Approved
0.6149 Remote Similarity NPD1551 Phase 2
0.6149 Remote Similarity NPD5404 Approved
0.6149 Remote Similarity NPD5408 Approved
0.6149 Remote Similarity NPD2935 Discontinued
0.6149 Remote Similarity NPD5406 Approved
0.6149 Remote Similarity NPD5405 Approved
0.6146 Remote Similarity NPD7597 Clinical (unspecified phase)
0.6145 Remote Similarity NPD7528 Approved
0.6139 Remote Similarity NPD825 Approved
0.6139 Remote Similarity NPD826 Approved
0.6134 Remote Similarity NPD2434 Approved
0.6118 Remote Similarity NPD9269 Phase 2

Structure

External Identifiers

PubChem CID   68443
ChEMBL   CHEMBL1650630
ZINC  

Physicochemical Properties

Molecular Weight:  153.04
ALogP:  -1.45
MLogP:  1.79
XLogP:  1.452
# Rotatable Bonds:  4
Polar Surface Area:  83.55
# H-Bond Aceptor:  3
# H-Bond Donor:  3
# Rings:  1
# Heavy Atoms:  11

Download Data

Data Type Select
General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs