Natural Product: NPC255721

Natural Product ID:  NPC255721
Common Name:   N-(2-Hydroxyphenyl)Acetamide
IUPAC Name:   N-(2-hydroxyphenyl)acetamide
Synonyms:  
Molecular Formula:   C8H9NO2
Standard InCHIKey:  ADVGKWPZRIDURE-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)
Canonical SMILES:  CC(=Nc1ccccc1O)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO1797 Homo sapiens Species Hominidae Eukaryota saliva PMID[24421258]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT2 Others Unspecified IC50 = 2630 nM PubChem BioAssay data set
NPT56 Individual Protein Beta-lactamase AmpC Escherichia coli K-12 Potency = 44668.4 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 31622.8 nM PubChem BioAssay data set
NPT4 Individual Protein Large T antigen Simian virus 40 IC50 6200 nM PubChem BioAssay data set
NPT63 Individual Protein Bromodomain adjacent to zinc finger domain protein 2B Homo sapiens Potency 100000 nM PubChem BioAssay data set
NPT1107 Organism Mycobacterium smegmatis str. MC2 155 Mycobacterium smegmatis str. MC2 155 MIC > 600000 nM 10.1039/C3MD00251A
NPT113 Cell Line RAW264.7 Mus musculus GI50 = 4204000 nM 10.1039/C3MD00251A
NPT1108 Organism Mycobacterium bovis BCG Mycobacterium bovis BCG MIC = 132000 nM 10.1039/C3MD00251A
NPT790 Organism Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis H37Rv MIC = 132000 nM 10.1039/C3MD00251A
NPT2 Others Unspecified AC50 18440 nM PubChem BioAssay data set
NPT152 Individual Protein Nuclear factor erythroid 2-related factor 2 Homo sapiens Potency 27306 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 38570.8 nM PubChem BioAssay data set
NPT49 Individual Protein DNA-(apurinic or apyrimidinic site) lyase Homo sapiens Potency 44668.4 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 275.4 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 1096.2 nM PubChem BioAssay data set

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC255721 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9231 High Similarity NPC76327
0.8972 High Similarity NPC9336
0.8846 High Similarity NPC311660
0.823 Intermediate Similarity NPC264782
0.8211 Intermediate Similarity NPC313466
0.8131 Intermediate Similarity NPC70201
0.7909 Intermediate Similarity NPC256838
0.7857 Intermediate Similarity NPC44836
0.7815 Intermediate Similarity NPC321869
0.7787 Intermediate Similarity NPC315632
0.771 Intermediate Similarity NPC314113
0.7538 Intermediate Similarity NPC122542
0.7519 Intermediate Similarity NPC297584
0.7479 Intermediate Similarity NPC222982
0.7451 Intermediate Similarity NPC15839
0.7426 Intermediate Similarity NPC307456
0.7422 Intermediate Similarity NPC473987
0.7372 Intermediate Similarity NPC315829
0.7368 Intermediate Similarity NPC47986
0.7345 Intermediate Similarity NPC178902
0.7248 Intermediate Similarity NPC476483
0.7176 Intermediate Similarity NPC208022
0.7167 Intermediate Similarity NPC322735
0.7155 Intermediate Similarity NPC231705
0.7121 Intermediate Similarity NPC91615
0.7107 Intermediate Similarity NPC329190
0.7094 Intermediate Similarity NPC142297
0.709 Intermediate Similarity NPC166667
0.7059 Intermediate Similarity NPC226914
0.7059 Intermediate Similarity NPC329358
0.7029 Intermediate Similarity NPC470404
0.7029 Intermediate Similarity NPC470403
0.7029 Intermediate Similarity NPC470394
0.6975 Remote Similarity NPC258056
0.6967 Remote Similarity NPC118202
0.6963 Remote Similarity NPC126637
0.6929 Remote Similarity NPC473769
0.6929 Remote Similarity NPC470395
0.6917 Remote Similarity NPC474149
0.6912 Remote Similarity NPC469828
0.6911 Remote Similarity NPC317254
0.6906 Remote Similarity NPC323798
0.6891 Remote Similarity NPC24101
0.6891 Remote Similarity NPC96224
0.6831 Remote Similarity NPC257142
0.6818 Remote Similarity NPC78154
0.6807 Remote Similarity NPC37584
0.6752 Remote Similarity NPC178681
0.675 Remote Similarity NPC153690
0.6739 Remote Similarity NPC314252
0.6738 Remote Similarity NPC473874
0.6735 Remote Similarity NPC70549
0.6733 Remote Similarity NPC100980
0.6724 Remote Similarity NPC289381
0.6724 Remote Similarity NPC155847
0.6724 Remote Similarity NPC29601
0.672 Remote Similarity NPC82963
0.6711 Remote Similarity NPC79911
0.6696 Remote Similarity NPC107619
0.6694 Remote Similarity NPC142599
0.6693 Remote Similarity NPC283760
0.6693 Remote Similarity NPC319950
0.669 Remote Similarity NPC284348
0.6667 Remote Similarity NPC112766
0.6667 Remote Similarity NPC38458
0.6667 Remote Similarity NPC311737
0.6644 Remote Similarity NPC120798
0.6644 Remote Similarity NPC231862
0.6644 Remote Similarity NPC306366
0.6641 Remote Similarity NPC205946
0.6635 Remote Similarity NPC65517
0.6619 Remote Similarity NPC181526
0.6619 Remote Similarity NPC204156
0.6594 Remote Similarity NPC43218
0.6587 Remote Similarity NPC147957
0.6575 Remote Similarity NPC184161
0.6554 Remote Similarity NPC477889
0.6549 Remote Similarity NPC260601
0.6538 Remote Similarity NPC474862
0.6528 Remote Similarity NPC220523
0.6518 Remote Similarity NPC92689
0.6515 Remote Similarity NPC325013
0.6512 Remote Similarity NPC289330
0.6512 Remote Similarity NPC17388
0.6512 Remote Similarity NPC471308
0.6512 Remote Similarity NPC160120
0.6512 Remote Similarity NPC53596
0.651 Remote Similarity NPC116573
0.6496 Remote Similarity NPC125732
0.6493 Remote Similarity NPC197680
0.6493 Remote Similarity NPC259098
0.649 Remote Similarity NPC57105
0.6462 Remote Similarity NPC473051
0.6462 Remote Similarity NPC473050
0.6457 Remote Similarity NPC258992
0.6455 Remote Similarity NPC248817
0.6449 Remote Similarity NPC204932
0.6429 Remote Similarity NPC205652
0.6429 Remote Similarity NPC470550
0.6423 Remote Similarity NPC316052
0.6423 Remote Similarity NPC174421
0.6414 Remote Similarity NPC161292
0.6412 Remote Similarity NPC27581
0.641 Remote Similarity NPC225381
0.6408 Remote Similarity NPC476462
0.6406 Remote Similarity NPC283468
0.6405 Remote Similarity NPC204179
0.6396 Remote Similarity NPC197783
0.6389 Remote Similarity NPC270094
0.6385 Remote Similarity NPC41801
0.6382 Remote Similarity NPC289776
0.6382 Remote Similarity NPC191863
0.6382 Remote Similarity NPC133470
0.6378 Remote Similarity NPC37302
0.6377 Remote Similarity NPC184437
0.6369 Remote Similarity NPC95898
0.6364 Remote Similarity NPC265146
0.6364 Remote Similarity NPC471314
0.6364 Remote Similarity NPC124436
0.6364 Remote Similarity NPC168750
0.6364 Remote Similarity NPC60553
0.6364 Remote Similarity NPC471315
0.6357 Remote Similarity NPC122009
0.6351 Remote Similarity NPC219383
0.6351 Remote Similarity NPC153769
0.6346 Remote Similarity NPC83241
0.6339 Remote Similarity NPC407
0.6339 Remote Similarity NPC307235
0.6339 Remote Similarity NPC184169
0.6339 Remote Similarity NPC23167
0.6333 Remote Similarity NPC10875
0.6333 Remote Similarity NPC68055
0.6333 Remote Similarity NPC10730
0.6331 Remote Similarity NPC317872
0.6327 Remote Similarity NPC241392
0.6323 Remote Similarity NPC44161
0.632 Remote Similarity NPC163674
0.632 Remote Similarity NPC227553
0.6312 Remote Similarity NPC476475
0.6309 Remote Similarity NPC36168
0.6308 Remote Similarity NPC268572
0.6306 Remote Similarity NPC150837
0.6306 Remote Similarity NPC175313
0.6306 Remote Similarity NPC286904
0.6296 Remote Similarity NPC4154
0.6294 Remote Similarity NPC318935
0.629 Remote Similarity NPC172046
0.629 Remote Similarity NPC290566
0.629 Remote Similarity NPC145638
0.6288 Remote Similarity NPC142577
0.6286 Remote Similarity NPC159589
0.6283 Remote Similarity NPC104216
0.6283 Remote Similarity NPC25493
0.6283 Remote Similarity NPC113460
0.6283 Remote Similarity NPC157213
0.6283 Remote Similarity NPC27974
0.6282 Remote Similarity NPC314940
0.6282 Remote Similarity NPC473764
0.6271 Remote Similarity NPC315921
0.6266 Remote Similarity NPC95412
0.6261 Remote Similarity NPC270547
0.626 Remote Similarity NPC252817
0.6258 Remote Similarity NPC314861
0.625 Remote Similarity NPC10286
0.625 Remote Similarity NPC303370
0.625 Remote Similarity NPC296712
0.625 Remote Similarity NPC155393
0.625 Remote Similarity NPC213
0.625 Remote Similarity NPC66775
0.625 Remote Similarity NPC291359
0.6241 Remote Similarity NPC316574
0.6235 Remote Similarity NPC272375
0.6232 Remote Similarity NPC255550
0.6232 Remote Similarity NPC308885
0.6228 Remote Similarity NPC98772
0.6228 Remote Similarity NPC242240
0.6228 Remote Similarity NPC258219
0.6228 Remote Similarity NPC280347
0.6228 Remote Similarity NPC123273
0.6228 Remote Similarity NPC177420
0.6228 Remote Similarity NPC318325
0.6224 Remote Similarity NPC280853
0.6222 Remote Similarity NPC151489
0.6222 Remote Similarity NPC476249
0.6216 Remote Similarity NPC144691
0.6214 Remote Similarity NPC215445
0.6211 Remote Similarity NPC478032
0.621 Remote Similarity NPC146530
0.6209 Remote Similarity NPC25899
0.6209 Remote Similarity NPC235628
0.6207 Remote Similarity NPC181709
0.6207 Remote Similarity NPC138117
0.6207 Remote Similarity NPC325292
0.6204 Remote Similarity NPC478147
0.6204 Remote Similarity NPC226662
0.619 Remote Similarity NPC166837
0.6188 Remote Similarity NPC315631
0.6187 Remote Similarity NPC93882
0.6187 Remote Similarity NPC130595
0.6183 Remote Similarity NPC43275

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC255721 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.9439 High Similarity NPD9342 Approved
0.9231 High Similarity NPD9507 Approved
0.8783 High Similarity NPD522 Approved
0.8125 Intermediate Similarity NPD9376 Approved
0.7949 Intermediate Similarity NPD254 Approved
0.7647 Intermediate Similarity NPD313 Approved
0.7293 Intermediate Similarity NPD204 Clinical (unspecified phase)
0.7288 Intermediate Similarity NPD308 Approved
0.7248 Intermediate Similarity NPD1394 Approved
0.7188 Intermediate Similarity NPD9723 Approved
0.7121 Intermediate Similarity NPD1393 Approved
0.7107 Intermediate Similarity NPD286 Approved
0.6992 Remote Similarity NPD756 Suspended
0.6912 Remote Similarity NPD5788 Clinical (unspecified phase)
0.6861 Remote Similarity NPD1422 Approved
0.6788 Remote Similarity NPD1169 Approved
0.6786 Remote Similarity NPD5819 Phase 2
0.6733 Remote Similarity NPD9087 Approved
0.6726 Remote Similarity NPD665 Phase 2
0.6715 Remote Similarity NPD6636 Phase 3
0.6712 Remote Similarity NPD948 Phase 3
0.6691 Remote Similarity NPD7083 Clinical (unspecified phase)
0.6667 Remote Similarity NPD1187 Discontinued
0.6667 Remote Similarity NPD980 Clinical (unspecified phase)
0.6667 Remote Similarity NPD9509 Clinical (unspecified phase)
0.6667 Remote Similarity NPD181 Approved
0.6667 Remote Similarity NPD3778 Approved
0.6644 Remote Similarity NPD3559 Clinical (unspecified phase)
0.6644 Remote Similarity NPD3557 Approved
0.6644 Remote Similarity NPD3558 Approved
0.6644 Remote Similarity NPD3556 Approved
0.6644 Remote Similarity NPD3560 Approved
0.6635 Remote Similarity NPD9088 Approved
0.662 Remote Similarity NPD1835 Phase 1
0.6619 Remote Similarity NPD3391 Approved
0.6577 Remote Similarity NPD935 Clinical (unspecified phase)
0.6577 Remote Similarity NPD6283 Phase 2
0.6577 Remote Similarity NPD6060 Clinical (unspecified phase)
0.6555 Remote Similarity NPD9610 Approved
0.6555 Remote Similarity NPD9608 Approved
0.6541 Remote Similarity NPD848 Approved
0.6541 Remote Similarity NPD850 Approved
0.6541 Remote Similarity NPD849 Approved
0.6507 Remote Similarity NPD711 Discontinued
0.6486 Remote Similarity NPD3684 Discontinued
0.6463 Remote Similarity NPD950 Clinical (unspecified phase)
0.6439 Remote Similarity NPD1158 Phase 2
0.6429 Remote Similarity NPD822 Approved
0.6414 Remote Similarity NPD2752 Clinical (unspecified phase)
0.6389 Remote Similarity NPD9089 Approved
0.6364 Remote Similarity NPD111 Approved
0.6364 Remote Similarity NPD2337 Clinical (unspecified phase)
0.6358 Remote Similarity NPD604 Clinical (unspecified phase)
0.6351 Remote Similarity NPD4003 Phase 3
0.635 Remote Similarity NPD2322 Discovery
0.634 Remote Similarity NPD861 Approved
0.634 Remote Similarity NPD863 Approved
0.634 Remote Similarity NPD862 Approved
0.6333 Remote Similarity NPD2469 Approved
0.6333 Remote Similarity NPD2468 Approved
0.6311 Remote Similarity NPD1444 Approved
0.6311 Remote Similarity NPD1445 Approved
0.6309 Remote Similarity NPD1162 Approved
0.6303 Remote Similarity NPD190 Phase 1
0.6301 Remote Similarity NPD2114 Discontinued
0.6299 Remote Similarity NPD9618 Approved
0.6299 Remote Similarity NPD9614 Approved
0.6296 Remote Similarity NPD1160 Phase 2
0.6296 Remote Similarity NPD7451 Discontinued
0.6296 Remote Similarity NPD9093 Approved
0.629 Remote Similarity NPD9380 Clinical (unspecified phase)
0.6286 Remote Similarity NPD471 Approved
0.6284 Remote Similarity NPD8330 Clinical (unspecified phase)
0.6283 Remote Similarity NPD9295 Approved
0.6282 Remote Similarity NPD4606 Clinical (unspecified phase)
0.6279 Remote Similarity NPD317 Approved
0.6279 Remote Similarity NPD9247 Phase 3
0.6279 Remote Similarity NPD318 Approved
0.6271 Remote Similarity NPD9273 Approved
0.6269 Remote Similarity NPD9587 Clinical (unspecified phase)
0.625 Remote Similarity NPD255 Approved
0.625 Remote Similarity NPD965 Approved
0.625 Remote Similarity NPD256 Approved
0.6241 Remote Similarity NPD9279 Approved
0.6241 Remote Similarity NPD964 Approved
0.6235 Remote Similarity NPD7883 Discontinued
0.6232 Remote Similarity NPD3145 Approved
0.6232 Remote Similarity NPD3144 Approved
0.6225 Remote Similarity NPD2789 Approved
0.622 Remote Similarity NPD2234 Approved
0.622 Remote Similarity NPD2228 Approved
0.622 Remote Similarity NPD2229 Approved
0.6218 Remote Similarity NPD9353 Approved
0.6216 Remote Similarity NPD1159 Approved
0.6212 Remote Similarity NPD9693 Approved
0.6212 Remote Similarity NPD9692 Approved
0.6207 Remote Similarity NPD1196 Approved
0.6203 Remote Similarity NPD6607 Clinical (unspecified phase)
0.62 Remote Similarity NPD5811 Approved
0.6194 Remote Similarity NPD3676 Clinical (unspecified phase)
0.6187 Remote Similarity NPD2674 Phase 3
0.6184 Remote Similarity NPD3812 Clinical (unspecified phase)
0.6183 Remote Similarity NPD2210 Approved
0.6183 Remote Similarity NPD2212 Approved
0.616 Remote Similarity NPD1108 Approved
0.616 Remote Similarity NPD1107 Approved
0.616 Remote Similarity NPD1792 Phase 2
0.6159 Remote Similarity NPD3136 Phase 2
0.6159 Remote Similarity NPD1314 Clinical (unspecified phase)
0.6159 Remote Similarity NPD5617 Suspended
0.6159 Remote Similarity NPD3296 Phase 1
0.6154 Remote Similarity NPD9613 Approved
0.6154 Remote Similarity NPD2933 Approved
0.6154 Remote Similarity NPD9615 Approved
0.6154 Remote Similarity NPD856 Approved
0.6154 Remote Similarity NPD9616 Approved
0.6154 Remote Similarity NPD2934 Approved
0.6154 Remote Similarity NPD16 Approved
0.6148 Remote Similarity NPD6320 Approved
0.6142 Remote Similarity NPD1762 Approved
0.6142 Remote Similarity NPD1105 Clinical (unspecified phase)
0.6142 Remote Similarity NPD1764 Approved
0.6138 Remote Similarity NPD1195 Approved
0.6129 Remote Similarity NPD3453 Discontinued
0.6122 Remote Similarity NPD1084 Clinical (unspecified phase)
0.6122 Remote Similarity NPD3141 Discontinued
0.6118 Remote Similarity NPD3236 Phase 3
0.6118 Remote Similarity NPD2366 Approved
0.6118 Remote Similarity NPD3237 Clinical (unspecified phase)
0.6116 Remote Similarity NPD1419 Approved
0.6116 Remote Similarity NPD1417 Approved
0.6115 Remote Similarity NPD864 Approved
0.6115 Remote Similarity NPD865 Approved
0.6111 Remote Similarity NPD521 Clinical (unspecified phase)
0.6111 Remote Similarity NPD9245 Clinical (unspecified phase)
0.6107 Remote Similarity NPD1759 Phase 1
0.6107 Remote Similarity NPD316 Approved
0.6104 Remote Similarity NPD5599 Discontinued
0.6102 Remote Similarity NPD2860 Approved
0.6102 Remote Similarity NPD2859 Approved
0.6098 Remote Similarity NPD563 Approved
0.6098 Remote Similarity NPD564 Approved
0.6096 Remote Similarity NPD2241 Approved
0.6094 Remote Similarity NPD2659 Approved
0.6094 Remote Similarity NPD3149 Approved
0.6094 Remote Similarity NPD3147 Approved
0.6094 Remote Similarity NPD3148 Approved
0.6094 Remote Similarity NPD2658 Approved
0.6094 Remote Similarity NPD3150 Approved
0.6093 Remote Similarity NPD5639 Clinical (unspecified phase)
0.609 Remote Similarity NPD1671 Clinical (unspecified phase)
0.609 Remote Similarity NPD1980 Approved
0.609 Remote Similarity NPD1981 Approved
0.609 Remote Similarity NPD3421 Phase 3
0.609 Remote Similarity NPD1983 Approved
0.6087 Remote Similarity NPD6159 Phase 2
0.6087 Remote Similarity NPD5352 Clinical (unspecified phase)
0.6081 Remote Similarity NPD1543 Discontinued
0.608 Remote Similarity NPD2678 Approved
0.608 Remote Similarity NPD2679 Approved
0.6077 Remote Similarity NPD9568 Approved
0.6076 Remote Similarity NPD1293 Approved
0.6071 Remote Similarity NPD5729 Clinical (unspecified phase)
0.6071 Remote Similarity NPD7477 Discontinued
0.6071 Remote Similarity NPD9073 Approved
0.6069 Remote Similarity NPD75 Approved
0.6069 Remote Similarity NPD9277 Approved
0.6066 Remote Similarity NPD2244 Clinical (unspecified phase)
0.6065 Remote Similarity NPD1191 Discontinued
0.6062 Remote Similarity NPD9690 Approved
0.6053 Remote Similarity NPD9094 Approved
0.605 Remote Similarity NPD9352 Approved
0.6047 Remote Similarity NPD1793 Approved
0.6047 Remote Similarity NPD1791 Approved
0.6047 Remote Similarity NPD5631 Phase 3
0.6043 Remote Similarity NPD3720 Discontinued
0.6043 Remote Similarity NPD4275 Approved
0.6043 Remote Similarity NPD4274 Approved
0.6042 Remote Similarity NPD852 Discontinued
0.6038 Remote Similarity NPD4083 Discontinued
0.6031 Remote Similarity NPD1758 Phase 1
0.6028 Remote Similarity NPD1106 Discontinued
0.6026 Remote Similarity NPD1678 Clinical (unspecified phase)
0.6017 Remote Similarity NPD1432 Clinical (unspecified phase)
0.6017 Remote Similarity NPD9296 Approved
0.6016 Remote Similarity NPD9377 Approved
0.6016 Remote Similarity NPD9379 Approved
0.6014 Remote Similarity NPD4895 Clinical (unspecified phase)
0.6013 Remote Similarity NPD6379 Discontinued
0.6013 Remote Similarity NPD2821 Approved
0.6013 Remote Similarity NPD4255 Phase 1
0.6 Remote Similarity NPD7752 Approved
0.6 Remote Similarity NPD7753 Approved
0.6 Remote Similarity NPD6809 Clinical (unspecified phase)
0.6 Remote Similarity NPD2561 Approved
0.6 Remote Similarity NPD5078 Clinical (unspecified phase)
0.6 Remote Similarity NPD9274 Approved
0.6 Remote Similarity NPD9276 Approved
0.6 Remote Similarity NPD9275 Approved
0.6 Remote Similarity NPD9278 Suspended

Structure

External Identifiers

PubChem CID   11972
ChEMBL   CHEMBL1456301
ZINC  

Physicochemical Properties

Molecular Weight:  151.06
ALogP:  -0.532
MLogP:  2.01
XLogP:  1.666
# Rotatable Bonds:  4
Polar Surface Area:  52.82
# H-Bond Aceptor:  2
# H-Bond Donor:  2
# Rings:  1
# Heavy Atoms:  11

Download Data

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Structure MOL file  
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Biological Activities  
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