Natural Product: NPC297584

Natural Product ID:  NPC297584
Common Name:   N-(3-Oxophenoxazin-2-Yl)Acetamide
IUPAC Name:   N-(3-oxophenoxazin-2-yl)acetamide
Synonyms:  
Molecular Formula:   C14H10N2O3
Standard InCHIKey:  DWOBTNSFRDZSMA-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C14H10N2O3/c1-8(17)15-10-6-11-14(7-12(10)18)19-13-5-3-2-4-9(13)16-11/h2-7H,1H3,(H,15,17)
Canonical SMILES:  CC(=Nc1cc2nc3ccccc3oc2cc1=O)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO19862 Gentiana siphonantha Species Gentianaceae Eukaryota UNPD*
NPO18957 Senecio ambavilla Species Asteraceae Eukaryota UNPD*
NPO21195 Ilex warburgii Species Aquifoliaceae Eukaryota UNPD*
NPO18353 Alstonia glabriflora Species Apocynaceae Eukaryota UNPD*
NPO18779 Melampodium longicorne Species Asteraceae Eukaryota UNPD*
NPO4124 Dimocarpus longan Species Sapindaceae Eukaryota UNPD*
NPO19737 Naucleopsis macrophylla Species Moraceae Eukaryota UNPD*
NPO21517 Lychnophora salicifolia Species Asteraceae Eukaryota UNPD*
NPO19596 Drepanocarpus lunatus NA NA NA UNPD*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT404 Cell Line CCRF-CEM Homo sapiens IC50 > 50000 nM 12431048
NPT4474 Cell Line CCRF-SB Homo sapiens IC50 = 3600 nM 12431048
NPT25 Cell Line MT4 Homo sapiens IC50 = 9500 nM 12431048
NPT165 Cell Line HeLa Homo sapiens IC50 = 8200 nM 12431048
NPT1171 Cell Line HEp-2 Homo sapiens IC50 = 1400 nM 12431048

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC297584 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9606 High Similarity NPC208022
0.8538 High Similarity NPC315632
0.8503 High Similarity NPC231862
0.8322 Intermediate Similarity NPC57105
0.8278 Intermediate Similarity NPC314861
0.8162 Intermediate Similarity NPC473987
0.7911 Intermediate Similarity NPC315631
0.7829 Intermediate Similarity NPC264782
0.7692 Intermediate Similarity NPC127362
0.7635 Intermediate Similarity NPC473769
0.7622 Intermediate Similarity NPC313886
0.7519 Intermediate Similarity NPC255721
0.7516 Intermediate Similarity NPC8467
0.745 Intermediate Similarity NPC473874
0.7355 Intermediate Similarity NPC112766
0.7267 Intermediate Similarity NPC260601
0.7225 Intermediate Similarity NPC108847
0.7197 Intermediate Similarity NPC70549
0.7133 Intermediate Similarity NPC476462
0.7099 Intermediate Similarity NPC76327
0.7047 Intermediate Similarity NPC476475
0.7 Intermediate Similarity NPC47986
0.6974 Remote Similarity NPC168750
0.694 Remote Similarity NPC9336
0.6927 Remote Similarity NPC214368
0.6871 Remote Similarity NPC313466
0.6842 Remote Similarity NPC314113
0.6815 Remote Similarity NPC226914
0.679 Remote Similarity NPC306366
0.6763 Remote Similarity NPC258992
0.6733 Remote Similarity NPC29650
0.6689 Remote Similarity NPC138365
0.6686 Remote Similarity NPC286195
0.6667 Remote Similarity NPC311660
0.6608 Remote Similarity NPC316161
0.6566 Remote Similarity NPC204179
0.6552 Remote Similarity NPC469829
0.6532 Remote Similarity NPC118776
0.6503 Remote Similarity NPC10875
0.6503 Remote Similarity NPC315257
0.6503 Remote Similarity NPC10730
0.6497 Remote Similarity NPC110741
0.6488 Remote Similarity NPC1527
0.6485 Remote Similarity NPC19023
0.6458 Remote Similarity NPC263835
0.645 Remote Similarity NPC477888
0.6424 Remote Similarity NPC301163
0.6407 Remote Similarity NPC118511
0.6389 Remote Similarity NPC256369
0.6382 Remote Similarity NPC471953
0.6375 Remote Similarity NPC315829
0.6364 Remote Similarity NPC122542
0.6358 Remote Similarity NPC200555
0.6358 Remote Similarity NPC196026
0.634 Remote Similarity NPC105541
0.6333 Remote Similarity NPC475411
0.6312 Remote Similarity NPC9373
0.6307 Remote Similarity NPC469831
0.6301 Remote Similarity NPC290069
0.6287 Remote Similarity NPC93653
0.6282 Remote Similarity NPC471316
0.6275 Remote Similarity NPC470392
0.6269 Remote Similarity NPC70201
0.6264 Remote Similarity NPC220560
0.625 Remote Similarity NPC323948
0.625 Remote Similarity NPC231382
0.625 Remote Similarity NPC270301
0.6241 Remote Similarity NPC313918
0.6237 Remote Similarity NPC316297
0.6237 Remote Similarity NPC314817
0.6237 Remote Similarity NPC66191
0.6234 Remote Similarity NPC169766
0.6233 Remote Similarity NPC17388
0.6233 Remote Similarity NPC289330
0.6233 Remote Similarity NPC471308
0.6233 Remote Similarity NPC160120
0.6233 Remote Similarity NPC53596
0.6224 Remote Similarity NPC303370
0.622 Remote Similarity NPC219383
0.6216 Remote Similarity NPC471314
0.6216 Remote Similarity NPC471315
0.6209 Remote Similarity NPC469961
0.6207 Remote Similarity NPC473432
0.6207 Remote Similarity NPC288943
0.6203 Remote Similarity NPC212850
0.6203 Remote Similarity NPC83289
0.6203 Remote Similarity NPC189724
0.62 Remote Similarity NPC250476
0.6196 Remote Similarity NPC470023
0.6188 Remote Similarity NPC473804
0.6183 Remote Similarity NPC220408
0.6176 Remote Similarity NPC299582
0.6174 Remote Similarity NPC211218
0.6169 Remote Similarity NPC274732
0.6167 Remote Similarity NPC469830
0.6167 Remote Similarity NPC232872
0.6164 Remote Similarity NPC321869
0.6162 Remote Similarity NPC314948
0.6162 Remote Similarity NPC470021
0.6162 Remote Similarity NPC478049
0.6159 Remote Similarity NPC41594
0.6154 Remote Similarity NPC177404
0.6154 Remote Similarity NPC13826
0.6154 Remote Similarity NPC209195
0.6149 Remote Similarity NPC119569
0.6149 Remote Similarity NPC247298
0.6145 Remote Similarity NPC42591
0.6133 Remote Similarity NPC325013
0.6131 Remote Similarity NPC256838
0.6129 Remote Similarity NPC91615
0.6122 Remote Similarity NPC41801
0.6117 Remote Similarity NPC470586
0.6115 Remote Similarity NPC44836
0.6095 Remote Similarity NPC285635
0.6093 Remote Similarity NPC476249
0.6092 Remote Similarity NPC73280
0.609 Remote Similarity NPC274441
0.6087 Remote Similarity NPC323798
0.6087 Remote Similarity NPC230403
0.6084 Remote Similarity NPC26872
0.608 Remote Similarity NPC9475
0.6074 Remote Similarity NPC245974
0.6074 Remote Similarity NPC307039
0.6071 Remote Similarity NPC146530
0.6071 Remote Similarity NPC26850
0.6063 Remote Similarity NPC125306
0.6059 Remote Similarity NPC257763
0.6056 Remote Similarity NPC166837
0.6054 Remote Similarity NPC43275
0.6037 Remote Similarity NPC257142
0.6036 Remote Similarity NPC103250
0.6031 Remote Similarity NPC318429
0.6026 Remote Similarity NPC62101
0.6026 Remote Similarity NPC95733
0.6023 Remote Similarity NPC168153
0.6022 Remote Similarity NPC262725
0.6021 Remote Similarity NPC473422
0.6012 Remote Similarity NPC56635
0.6 Remote Similarity NPC235628
0.6 Remote Similarity NPC307456
0.6 Remote Similarity NPC144691
0.6 Remote Similarity NPC175298
0.5989 Remote Similarity NPC66083
0.5989 Remote Similarity NPC283152
0.5989 Remote Similarity NPC474902
0.5986 Remote Similarity NPC95977
0.5978 Remote Similarity NPC28510
0.5978 Remote Similarity NPC116096
0.5975 Remote Similarity NPC469828
0.5973 Remote Similarity NPC473050
0.5973 Remote Similarity NPC83279
0.5973 Remote Similarity NPC473051
0.5972 Remote Similarity NPC322735
0.5971 Remote Similarity NPC139891
0.5971 Remote Similarity NPC128730
0.5965 Remote Similarity NPC79911
0.5964 Remote Similarity NPC182119
0.5956 Remote Similarity NPC132725
0.5948 Remote Similarity NPC218323
0.5943 Remote Similarity NPC258773
0.5943 Remote Similarity NPC471604
0.5943 Remote Similarity NPC471648
0.594 Remote Similarity NPC476483
0.5931 Remote Similarity NPC329190
0.5931 Remote Similarity NPC118202
0.5929 Remote Similarity NPC176971
0.5928 Remote Similarity NPC284348
0.5928 Remote Similarity NPC308392
0.5928 Remote Similarity NPC287208
0.5928 Remote Similarity NPC184161
0.5924 Remote Similarity NPC184437
0.5921 Remote Similarity NPC205946
0.5914 Remote Similarity NPC475190
0.5907 Remote Similarity NPC471736
0.5906 Remote Similarity NPC120798
0.5906 Remote Similarity NPC15839
0.5904 Remote Similarity NPC470019
0.5903 Remote Similarity NPC266116
0.5899 Remote Similarity NPC2518
0.5899 Remote Similarity NPC109637
0.5896 Remote Similarity NPC71205
0.589 Remote Similarity NPC470404
0.589 Remote Similarity NPC470394
0.589 Remote Similarity NPC222982
0.589 Remote Similarity NPC470403
0.5889 Remote Similarity NPC161887
0.5889 Remote Similarity NPC219963
0.5889 Remote Similarity NPC472163
0.5889 Remote Similarity NPC266551
0.5887 Remote Similarity NPC157473
0.5887 Remote Similarity NPC151530
0.5882 Remote Similarity NPC29477
0.5879 Remote Similarity NPC20249
0.5874 Remote Similarity NPC329358
0.5874 Remote Similarity NPC141068
0.5872 Remote Similarity NPC191863
0.5872 Remote Similarity NPC133470
0.5872 Remote Similarity NPC289776
0.5862 Remote Similarity NPC471652
0.5862 Remote Similarity NPC90903

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC297584 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8 Intermediate Similarity NPD254 Approved
0.7857 Intermediate Similarity NPD1393 Approved
0.7697 Intermediate Similarity NPD980 Clinical (unspecified phase)
0.7639 Intermediate Similarity NPD204 Clinical (unspecified phase)
0.7534 Intermediate Similarity NPD7083 Clinical (unspecified phase)
0.7483 Intermediate Similarity NPD756 Suspended
0.7185 Intermediate Similarity NPD9342 Approved
0.7134 Intermediate Similarity NPD3778 Approved
0.7114 Intermediate Similarity NPD1422 Approved
0.7099 Intermediate Similarity NPD9507 Approved
0.7097 Intermediate Similarity NPD8330 Clinical (unspecified phase)
0.6988 Remote Similarity NPD4020 Clinical (unspecified phase)
0.6918 Remote Similarity NPD2366 Approved
0.6894 Remote Similarity NPD1012 Discontinued
0.6795 Remote Similarity NPD2752 Clinical (unspecified phase)
0.6783 Remote Similarity NPD522 Approved
0.6781 Remote Similarity NPD4993 Discontinued
0.6753 Remote Similarity NPD965 Approved
0.6746 Remote Similarity NPD3965 Phase 1
0.6733 Remote Similarity NPD9694 Discovery
0.673 Remote Similarity NPD4003 Phase 3
0.6728 Remote Similarity NPD6060 Clinical (unspecified phase)
0.6726 Remote Similarity NPD2525 Clinical (unspecified phase)
0.6711 Remote Similarity NPD5788 Clinical (unspecified phase)
0.6711 Remote Similarity NPD822 Approved
0.6708 Remote Similarity NPD4205 Phase 3
0.6708 Remote Similarity NPD4201 Clinical (unspecified phase)
0.6687 Remote Similarity NPD5811 Approved
0.6686 Remote Similarity NPD1898 Discontinued
0.6627 Remote Similarity NPD4943 Phase 2
0.6627 Remote Similarity NPD4944 Phase 2
0.6624 Remote Similarity NPD1084 Clinical (unspecified phase)
0.6624 Remote Similarity NPD1305 Clinical (unspecified phase)
0.6608 Remote Similarity NPD3580 Discontinued
0.6603 Remote Similarity NPD5481 Discontinued
0.6599 Remote Similarity NPD850 Approved
0.6599 Remote Similarity NPD848 Approved
0.6599 Remote Similarity NPD849 Approved
0.6577 Remote Similarity NPD1314 Clinical (unspecified phase)
0.6568 Remote Similarity NPD5078 Clinical (unspecified phase)
0.6543 Remote Similarity NPD3296 Phase 1
0.6527 Remote Similarity NPD1559 Discontinued
0.6503 Remote Similarity NPD3236 Phase 3
0.6503 Remote Similarity NPD3237 Clinical (unspecified phase)
0.6497 Remote Similarity NPD2241 Approved
0.6488 Remote Similarity NPD2680 Approved
0.6488 Remote Similarity NPD2247 Approved
0.6488 Remote Similarity NPD2249 Approved
0.6488 Remote Similarity NPD2681 Approved
0.6485 Remote Similarity NPD7318 Phase 3
0.6481 Remote Similarity NPD789 Phase 2
0.648 Remote Similarity NPD4325 Phase 2
0.648 Remote Similarity NPD4324 Phase 2
0.6478 Remote Similarity NPD2114 Discontinued
0.6471 Remote Similarity NPD3952 Approved
0.6471 Remote Similarity NPD3951 Phase 3
0.6471 Remote Similarity NPD3953 Clinical (unspecified phase)
0.6467 Remote Similarity NPD7566 Clinical (unspecified phase)
0.6463 Remote Similarity NPD3812 Clinical (unspecified phase)
0.6441 Remote Similarity NPD4515 Suspended
0.6441 Remote Similarity NPD6393 Clinical (unspecified phase)
0.6437 Remote Similarity NPD6104 Discontinued
0.6429 Remote Similarity NPD2162 Clinical (unspecified phase)
0.6429 Remote Similarity NPD2341 Discontinued
0.6424 Remote Similarity NPD2842 Clinical (unspecified phase)
0.6413 Remote Similarity NPD2339 Phase 3
0.6412 Remote Similarity NPD2216 Approved
0.6412 Remote Similarity NPD2215 Approved
0.6407 Remote Similarity NPD3453 Discontinued
0.6402 Remote Similarity NPD4255 Phase 1
0.6395 Remote Similarity NPD1158 Phase 2
0.6393 Remote Similarity NPD772 Phase 3
0.6391 Remote Similarity NPD2821 Approved
0.6386 Remote Similarity NPD6063 Approved
0.6382 Remote Similarity NPD7477 Discontinued
0.6379 Remote Similarity NPD6654 Clinical (unspecified phase)
0.6374 Remote Similarity NPD6607 Clinical (unspecified phase)
0.6369 Remote Similarity NPD5719 Approved
0.6364 Remote Similarity NPD7317 Phase 3
0.6353 Remote Similarity NPD4606 Clinical (unspecified phase)
0.6341 Remote Similarity NPD1557 Discontinued
0.6335 Remote Similarity NPD2335 Discontinued
0.6331 Remote Similarity NPD3251 Approved
0.6331 Remote Similarity NPD9376 Approved
0.6325 Remote Similarity NPD5294 Clinical (unspecified phase)
0.6319 Remote Similarity NPD950 Clinical (unspecified phase)
0.6319 Remote Similarity NPD1678 Clinical (unspecified phase)
0.6309 Remote Similarity NPD3827 Clinical (unspecified phase)
0.6306 Remote Similarity NPD3656 Approved
0.6306 Remote Similarity NPD521 Clinical (unspecified phase)
0.6296 Remote Similarity NPD7043 Discontinued
0.6294 Remote Similarity NPD4986 Clinical (unspecified phase)
0.6294 Remote Similarity NPD6379 Discontinued
0.6292 Remote Similarity NPD3153 Approved
0.6292 Remote Similarity NPD3154 Approved
0.6287 Remote Similarity NPD3557 Approved
0.6287 Remote Similarity NPD3560 Approved
0.6287 Remote Similarity NPD3556 Approved
0.6287 Remote Similarity NPD3559 Clinical (unspecified phase)
0.6287 Remote Similarity NPD3558 Approved
0.6282 Remote Similarity NPD3260 Discontinued
0.6278 Remote Similarity NPD6136 Phase 2
0.6271 Remote Similarity NPD5083 Clinical (unspecified phase)
0.6267 Remote Similarity NPD1160 Phase 2
0.6266 Remote Similarity NPD4597 Approved
0.6266 Remote Similarity NPD4598 Approved
0.6265 Remote Similarity NPD1769 Discontinued
0.6258 Remote Similarity NPD3627 Approved
0.6257 Remote Similarity NPD5847 Phase 1
0.625 Remote Similarity NPD4604 Approved
0.625 Remote Similarity NPD1191 Discontinued
0.625 Remote Similarity NPD4605 Approved
0.6243 Remote Similarity NPD5602 Clinical (unspecified phase)
0.6243 Remote Similarity NPD5938 Phase 3
0.6229 Remote Similarity NPD2826 Approved
0.6229 Remote Similarity NPD2825 Approved
0.6229 Remote Similarity NPD2827 Approved
0.6223 Remote Similarity NPD3802 Phase 3
0.6222 Remote Similarity NPD6608 Clinical (unspecified phase)
0.6222 Remote Similarity NPD2792 Approved
0.6222 Remote Similarity NPD2542 Clinical (unspecified phase)
0.6222 Remote Similarity NPD7326 Phase 3
0.622 Remote Similarity NPD5267 Discontinued
0.6218 Remote Similarity NPD696 Discontinued
0.6209 Remote Similarity NPD9243 Approved
0.6207 Remote Similarity NPD4354 Approved
0.6207 Remote Similarity NPD5603 Clinical (unspecified phase)
0.6205 Remote Similarity NPD2433 Clinical (unspecified phase)
0.6203 Remote Similarity NPD9245 Clinical (unspecified phase)
0.6203 Remote Similarity NPD7753 Approved
0.6203 Remote Similarity NPD7752 Approved
0.6196 Remote Similarity NPD9509 Clinical (unspecified phase)
0.6196 Remote Similarity NPD4186 Clinical (unspecified phase)
0.6194 Remote Similarity NPD654 Phase 3
0.6193 Remote Similarity NPD6211 Clinical (unspecified phase)
0.6193 Remote Similarity NPD6293 Clinical (unspecified phase)
0.6185 Remote Similarity NPD5858 Discontinued
0.6183 Remote Similarity NPD5547 Clinical (unspecified phase)
0.6182 Remote Similarity NPD2312 Discontinued
0.618 Remote Similarity NPD1334 Clinical (unspecified phase)
0.618 Remote Similarity NPD7546 Discontinued
0.6178 Remote Similarity NPD6593 Clinical (unspecified phase)
0.6176 Remote Similarity NPD3252 Approved
0.617 Remote Similarity NPD5848 Clinical (unspecified phase)
0.6164 Remote Similarity NPD2594 Approved
0.6164 Remote Similarity NPD2595 Approved
0.6145 Remote Similarity NPD3684 Discontinued
0.6139 Remote Similarity NPD1725 Approved
0.6136 Remote Similarity NPD2425 Phase 1
0.6131 Remote Similarity NPD6737 Phase 2
0.6131 Remote Similarity NPD6738 Phase 2
0.6129 Remote Similarity NPD3463 Discontinued
0.6124 Remote Similarity NPD1891 Discontinued
0.6121 Remote Similarity NPD2883 Discontinued
0.6118 Remote Similarity NPD955 Approved
0.6118 Remote Similarity NPD5266 Clinical (unspecified phase)
0.6115 Remote Similarity NPD5374 Approved
0.6115 Remote Similarity NPD5373 Approved
0.6114 Remote Similarity NPD1166 Clinical (unspecified phase)
0.6111 Remote Similarity NPD3316 Clinical (unspecified phase)
0.6108 Remote Similarity NPD8249 Clinical (unspecified phase)
0.6105 Remote Similarity NPD7126 Discontinued
0.6103 Remote Similarity NPD3945 Discontinued
0.6102 Remote Similarity NPD6184 Discontinued
0.6096 Remote Similarity NPD6757 Phase 3
0.6092 Remote Similarity NPD2248 Approved
0.6092 Remote Similarity NPD2246 Approved
0.6087 Remote Similarity NPD2086 Clinical (unspecified phase)
0.6087 Remote Similarity NPD2085 Suspended
0.608 Remote Similarity NPD5521 Clinical (unspecified phase)
0.6075 Remote Similarity NPD4979 Clinical (unspecified phase)
0.6069 Remote Similarity NPD565 Phase 2
0.6067 Remote Similarity NPD3676 Clinical (unspecified phase)
0.6067 Remote Similarity NPD4129 Approved
0.6062 Remote Similarity NPD7153 Discontinued
0.6056 Remote Similarity NPD6045 Phase 3
0.6056 Remote Similarity NPD308 Approved
0.6054 Remote Similarity NPD6590 Discontinued
0.6045 Remote Similarity NPD5900 Clinical (unspecified phase)
0.6044 Remote Similarity NPD5800 Discontinued
0.6044 Remote Similarity NPD5558 Clinical (unspecified phase)
0.6034 Remote Similarity NPD4083 Discontinued
0.6033 Remote Similarity NPD4372 Phase 1
0.6033 Remote Similarity NPD4302 Clinical (unspecified phase)
0.6031 Remote Similarity NPD9365 Approved
0.6027 Remote Similarity NPD313 Approved
0.6025 Remote Similarity NPD2459 Approved
0.6025 Remote Similarity NPD2460 Phase 3
0.6025 Remote Similarity NPD2458 Approved
0.6023 Remote Similarity NPD5132 Clinical (unspecified phase)
0.6023 Remote Similarity NPD419 Approved
0.6023 Remote Similarity NPD3368 Phase 2
0.6022 Remote Similarity NPD6638 Approved
0.6022 Remote Similarity NPD5512 Phase 3
0.6022 Remote Similarity NPD6550 Discontinued
0.6014 Remote Similarity NPD821 Approved
0.6013 Remote Similarity NPD2250 Discontinued
0.6013 Remote Similarity NPD6636 Phase 3
0.6011 Remote Similarity NPD4258 Approved
0.6011 Remote Similarity NPD4259 Approved

Structure

External Identifiers

PubChem CID   193337
ChEMBL   CHEMBL151988
ZINC  

Physicochemical Properties

Molecular Weight:  254.07
ALogP:  -0.7666
MLogP:  2.45
XLogP:  2.138
# Rotatable Bonds:  3
Polar Surface Area:  71.25
# H-Bond Aceptor:  4
# H-Bond Donor:  1
# Rings:  3
# Heavy Atoms:  19

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
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Biological Activities  
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