Natural Product: NPC287208

Natural Product ID:  NPC287208
Common Name:   n.a.
IUPAC Name:  
Synonyms:   1-Methoxycanthinone
Molecular Formula:   C15H10N2O2
Standard InCHIKey:  LEPXKGXTXIACRO-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C15H10N2O2/c1-19-12-8-16-10-6-7-13(18)17-11-5-3-2-4-9(11)14(12)15(10)17/h2-8H,1H3
Canonical SMILES:  COc1cnc2c3c1c1ccccc1n3c(=O)cc2
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO15443 Ailanthus altissima Species Simaroubaceae Eukaryota xylem DOI[10.1248/cpb.24.1532]
NPO809 Leitneria floridana Species Simaroubaceae Eukaryota Aerial parts PMID[11141127]
NPO6884 Ailanthi cortex NA NA NA TCMSP*
NPO15443 Ailanthus altissima Species Simaroubaceae Eukaryota TM-MC*
NPO15443 Ailanthus altissima Species Simaroubaceae Eukaryota TCMID*
NPO15115 Ailanthus excelsa Species Simaroubaceae Eukaryota TCMID*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT1114 Organism Human immunodeficiency virus Human immunodeficiency virus EC50 = 20.6 ug/ml 15270576
NPT2 Others Unspecified IC50 = 5.76 ug/ml 6619885
NPT91 Cell Line KB Homo sapiens ED50 = 3.6 ug/ml 11141127
NPT81 Cell Line A549 Homo sapiens ED50 = 4.3 ug/ml 11141127
NPT180 Cell Line HCT-8 Homo sapiens ED50 = 3.6 ug/ml 11141127
NPT308 Cell Line CAKI-1 Homo sapiens ED50 = 3.6 ug/ml 11141127
NPT83 Cell Line MCF7 Homo sapiens ED50 = 13.5 ug/ml 11141127
NPT147 Cell Line SK-MEL-2 Homo sapiens ED50 > 20 ug/ml 11141127
NPT147 Cell Line SK-MEL-2 Homo sapiens Inhibition = 46 % 11141127
NPT2 Others Unspecified Ratio IC50/EC50 > 391 11141127
NPT759 Cell Line H9 Homo sapiens IC50 > 100 ug/ml 11141127
NPT1114 Organism Human immunodeficiency virus Human immunodeficiency virus IC50 = 0.256 ug/ml 11141127
NPT178 Individual Protein Protein-tyrosine phosphatase 1B Homo sapiens Inhibition = 23.7 % 25819098

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC287208 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9319 High Similarity NPC174672
0.9219 High Similarity NPC174758
0.9189 High Similarity NPC198673
0.9167 High Similarity NPC82548
0.9144 High Similarity NPC267928
0.8995 High Similarity NPC239954
0.8995 High Similarity NPC168911
0.8939 High Similarity NPC274982
0.8901 High Similarity NPC19872
0.8841 High Similarity NPC141053
0.8698 High Similarity NPC212213
0.8571 High Similarity NPC200836
0.8477 Intermediate Similarity NPC245816
0.8477 Intermediate Similarity NPC476138
0.8477 Intermediate Similarity NPC53144
0.8472 Intermediate Similarity NPC472434
0.845 Intermediate Similarity NPC185782
0.8426 Intermediate Similarity NPC211813
0.8342 Intermediate Similarity NPC12649
0.8325 Intermediate Similarity NPC26679
0.8318 Intermediate Similarity NPC26543
0.8284 Intermediate Similarity NPC476287
0.8251 Intermediate Similarity NPC472435
0.8227 Intermediate Similarity NPC85273
0.8208 Intermediate Similarity NPC314954
0.8204 Intermediate Similarity NPC470799
0.8204 Intermediate Similarity NPC8022
0.8191 Intermediate Similarity NPC232727
0.815 Intermediate Similarity NPC295898
0.8142 Intermediate Similarity NPC472436
0.8141 Intermediate Similarity NPC176538
0.8109 Intermediate Similarity NPC475774
0.8031 Intermediate Similarity NPC20249
0.8 Intermediate Similarity NPC99891
0.7979 Intermediate Similarity NPC284678
0.7963 Intermediate Similarity NPC260434
0.7961 Intermediate Similarity NPC167860
0.7961 Intermediate Similarity NPC123976
0.7935 Intermediate Similarity NPC293487
0.7926 Intermediate Similarity NPC469554
0.7926 Intermediate Similarity NPC476518
0.7926 Intermediate Similarity NPC101543
0.7915 Intermediate Similarity NPC17565
0.7903 Intermediate Similarity NPC478182
0.7892 Intermediate Similarity NPC285558
0.7884 Intermediate Similarity NPC121658
0.7884 Intermediate Similarity NPC14651
0.7876 Intermediate Similarity NPC161887
0.7876 Intermediate Similarity NPC266551
0.7876 Intermediate Similarity NPC219963
0.785 Intermediate Similarity NPC65277
0.785 Intermediate Similarity NPC122436
0.784 Intermediate Similarity NPC60621
0.783 Intermediate Similarity NPC292958
0.783 Intermediate Similarity NPC213530
0.783 Intermediate Similarity NPC193267
0.7828 Intermediate Similarity NPC30540
0.7824 Intermediate Similarity NPC24864
0.7773 Intermediate Similarity NPC182222
0.7758 Intermediate Similarity NPC148889
0.7754 Intermediate Similarity NPC177404
0.7754 Intermediate Similarity NPC478185
0.775 Intermediate Similarity NPC84853
0.775 Intermediate Similarity NPC226202
0.7749 Intermediate Similarity NPC111624
0.7737 Intermediate Similarity NPC32534
0.7734 Intermediate Similarity NPC81535
0.7734 Intermediate Similarity NPC476167
0.7725 Intermediate Similarity NPC478183
0.7721 Intermediate Similarity NPC216612
0.7713 Intermediate Similarity NPC478184
0.7688 Intermediate Similarity NPC26850
0.7685 Intermediate Similarity NPC192315
0.7682 Intermediate Similarity NPC196718
0.7682 Intermediate Similarity NPC102593
0.7674 Intermediate Similarity NPC310118
0.765 Intermediate Similarity NPC92111
0.7644 Intermediate Similarity NPC91895
0.7638 Intermediate Similarity NPC296527
0.7633 Intermediate Similarity NPC470500
0.763 Intermediate Similarity NPC264176
0.7623 Intermediate Similarity NPC235685
0.7622 Intermediate Similarity NPC26872
0.7619 Intermediate Similarity NPC118511
0.761 Intermediate Similarity NPC121772
0.761 Intermediate Similarity NPC315957
0.7608 Intermediate Similarity NPC266249
0.76 Intermediate Similarity NPC134079
0.76 Intermediate Similarity NPC76748
0.7589 Intermediate Similarity NPC101350
0.7586 Intermediate Similarity NPC13880
0.7586 Intermediate Similarity NPC53534
0.758 Intermediate Similarity NPC257851
0.7574 Intermediate Similarity NPC307963
0.7571 Intermediate Similarity NPC469589
0.7561 Intermediate Similarity NPC187558
0.7548 Intermediate Similarity NPC118832
0.7548 Intermediate Similarity NPC47059
0.7548 Intermediate Similarity NPC274291
0.7548 Intermediate Similarity NPC264166
0.7548 Intermediate Similarity NPC165349
0.7548 Intermediate Similarity NPC329708
0.7546 Intermediate Similarity NPC323969
0.7536 Intermediate Similarity NPC5145
0.7536 Intermediate Similarity NPC123839
0.7525 Intermediate Similarity NPC324149
0.7524 Intermediate Similarity NPC234197
0.7512 Intermediate Similarity NPC162530
0.75 Intermediate Similarity NPC110151
0.75 Intermediate Similarity NPC146418
0.7476 Intermediate Similarity NPC193238
0.7476 Intermediate Similarity NPC18487
0.7476 Intermediate Similarity NPC287437
0.7475 Intermediate Similarity NPC48938
0.7466 Intermediate Similarity NPC471762
0.7465 Intermediate Similarity NPC94157
0.7465 Intermediate Similarity NPC118940
0.7465 Intermediate Similarity NPC128115
0.7464 Intermediate Similarity NPC36229
0.7464 Intermediate Similarity NPC16452
0.7464 Intermediate Similarity NPC472259
0.7464 Intermediate Similarity NPC476581
0.7452 Intermediate Similarity NPC57398
0.7446 Intermediate Similarity NPC478186
0.744 Intermediate Similarity NPC477019
0.7437 Intermediate Similarity NPC84478
0.7429 Intermediate Similarity NPC472111
0.7429 Intermediate Similarity NPC238457
0.7427 Intermediate Similarity NPC474916
0.7421 Intermediate Similarity NPC157931
0.7418 Intermediate Similarity NPC208284
0.7415 Intermediate Similarity NPC251090
0.7413 Intermediate Similarity NPC74382
0.7413 Intermediate Similarity NPC206251
0.7407 Intermediate Similarity NPC473513
0.7404 Intermediate Similarity NPC470586
0.7404 Intermediate Similarity NPC258048
0.7398 Intermediate Similarity NPC224764
0.7395 Intermediate Similarity NPC152620
0.7391 Intermediate Similarity NPC4071
0.7391 Intermediate Similarity NPC476578
0.7391 Intermediate Similarity NPC476582
0.7387 Intermediate Similarity NPC176127
0.7387 Intermediate Similarity NPC66777
0.7385 Intermediate Similarity NPC472099
0.7383 Intermediate Similarity NPC53069
0.7383 Intermediate Similarity NPC202768
0.7383 Intermediate Similarity NPC472098
0.7383 Intermediate Similarity NPC296482
0.7381 Intermediate Similarity NPC475070
0.7378 Intermediate Similarity NPC253675
0.7373 Intermediate Similarity NPC173080
0.7373 Intermediate Similarity NPC303658
0.7371 Intermediate Similarity NPC470020
0.7361 Intermediate Similarity NPC148183
0.7361 Intermediate Similarity NPC152768
0.7359 Intermediate Similarity NPC161801
0.7353 Intermediate Similarity NPC133140
0.7353 Intermediate Similarity NPC195268
0.7346 Intermediate Similarity NPC470164
0.7346 Intermediate Similarity NPC323345
0.7333 Intermediate Similarity NPC223427
0.7333 Intermediate Similarity NPC329631
0.733 Intermediate Similarity NPC25899
0.7328 Intermediate Similarity NPC91868
0.7328 Intermediate Similarity NPC63971
0.7327 Intermediate Similarity NPC305984
0.7323 Intermediate Similarity NPC42979
0.7321 Intermediate Similarity NPC31930
0.732 Intermediate Similarity NPC1527
0.7313 Intermediate Similarity NPC42591
0.7313 Intermediate Similarity NPC240384
0.7311 Intermediate Similarity NPC313189
0.7302 Intermediate Similarity NPC96405
0.7302 Intermediate Similarity NPC171409
0.7297 Intermediate Similarity NPC470018
0.7291 Intermediate Similarity NPC224327
0.7291 Intermediate Similarity NPC242928
0.7289 Intermediate Similarity NPC473186
0.7286 Intermediate Similarity NPC222592
0.7286 Intermediate Similarity NPC168486
0.7285 Intermediate Similarity NPC322482
0.7282 Intermediate Similarity NPC314940
0.7282 Intermediate Similarity NPC473764
0.7281 Intermediate Similarity NPC170114
0.7281 Intermediate Similarity NPC288349
0.7269 Intermediate Similarity NPC74562
0.7269 Intermediate Similarity NPC471080
0.7269 Intermediate Similarity NPC295228
0.7269 Intermediate Similarity NPC469592
0.7269 Intermediate Similarity NPC151781
0.7269 Intermediate Similarity NPC316181
0.7269 Intermediate Similarity NPC477549
0.7268 Intermediate Similarity NPC56233
0.7265 Intermediate Similarity NPC74575
0.7264 Intermediate Similarity NPC284559
0.7264 Intermediate Similarity NPC476121
0.7264 Intermediate Similarity NPC476124
0.7261 Intermediate Similarity NPC72905
0.7257 Intermediate Similarity NPC180504

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC287208 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8342 Intermediate Similarity NPD4372 Phase 1
0.8077 Intermediate Similarity NPD7823 Clinical (unspecified phase)
0.789 Intermediate Similarity NPD6223 Clinical (unspecified phase)
0.785 Intermediate Similarity NPD3478 Clinical (unspecified phase)
0.785 Intermediate Similarity NPD3477 Phase 2
0.7817 Intermediate Similarity NPD6961 Discontinued
0.7793 Intermediate Similarity NPD2921 Clinical (unspecified phase)
0.7783 Intermediate Similarity NPD4958 Clinical (unspecified phase)
0.7766 Intermediate Similarity NPD1033 Clinical (unspecified phase)
0.7766 Intermediate Similarity NPD1034 Phase 3
0.775 Intermediate Similarity NPD1304 Clinical (unspecified phase)
0.7718 Intermediate Similarity NPD4795 Phase 2
0.7706 Intermediate Similarity NPD5559 Phase 2
0.77 Intermediate Similarity NPD4429 Discontinued
0.77 Intermediate Similarity NPD5948 Phase 2
0.77 Intermediate Similarity NPD6569 Phase 2
0.7674 Intermediate Similarity NPD4881 Clinical (unspecified phase)
0.7667 Intermediate Similarity NPD6567 Clinical (unspecified phase)
0.7655 Intermediate Similarity NPD5483 Clinical (unspecified phase)
0.7639 Intermediate Similarity NPD1856 Discontinued
0.7628 Intermediate Similarity NPD6242 Discontinued
0.761 Intermediate Similarity NPD1740 Approved
0.761 Intermediate Similarity NPD1739 Approved
0.7598 Intermediate Similarity NPD5482 Discontinued
0.7585 Intermediate Similarity NPD5513 Phase 2
0.7583 Intermediate Similarity NPD3939 Suspended
0.7574 Intermediate Similarity NPD1038 Approved
0.7569 Intermediate Similarity NPD6247 Clinical (unspecified phase)
0.7559 Intermediate Similarity NPD6140 Clinical (unspecified phase)
0.7548 Intermediate Similarity NPD4035 Approved
0.7548 Intermediate Similarity NPD4038 Approved
0.7548 Intermediate Similarity NPD4037 Approved
0.7548 Intermediate Similarity NPD4033 Approved
0.7548 Intermediate Similarity NPD4039 Approved
0.7548 Intermediate Similarity NPD32 Approved
0.7548 Intermediate Similarity NPD4034 Approved
0.7548 Intermediate Similarity NPD31 Approved
0.7548 Intermediate Similarity NPD4036 Approved
0.7548 Intermediate Similarity NPD4122 Approved
0.7534 Intermediate Similarity NPD7426 Phase 1
0.7524 Intermediate Similarity NPD7467 Discontinued
0.7513 Intermediate Similarity NPD9705 Discontinued
0.7513 Intermediate Similarity NPD112 Approved
0.7512 Intermediate Similarity NPD5601 Phase 2
0.7512 Intermediate Similarity NPD3321 Discontinued
0.7487 Intermediate Similarity NPD4889 Approved
0.7476 Intermediate Similarity NPD4548 Discontinued
0.7476 Intermediate Similarity NPD7222 Phase 2
0.7455 Intermediate Similarity NPD5640 Discontinued
0.7455 Intermediate Similarity NPD7603 Discontinued
0.7454 Intermediate Similarity NPD6568 Discontinued
0.7445 Intermediate Similarity NPD6790 Phase 1
0.7424 Intermediate Similarity NPD3386 Phase 2
0.7424 Intermediate Similarity NPD4204 Approved
0.7424 Intermediate Similarity NPD4203 Approved
0.7421 Intermediate Similarity NPD7268 Clinical (unspecified phase)
0.7409 Intermediate Similarity NPD6872 Clinical (unspecified phase)
0.7407 Intermediate Similarity NPD2581 Approved
0.7407 Intermediate Similarity NPD2582 Approved
0.7396 Intermediate Similarity NPD2915 Discontinued
0.7383 Intermediate Similarity NPD3816 Phase 1
0.7383 Intermediate Similarity NPD3815 Phase 1
0.738 Intermediate Similarity NPD7068 Approved
0.738 Intermediate Similarity NPD7067 Approved
0.7366 Intermediate Similarity NPD4418 Discontinued
0.7366 Intermediate Similarity NPD6861 Clinical (unspecified phase)
0.7362 Intermediate Similarity NPD8049 Phase 2
0.7358 Intermediate Similarity NPD5658 Approved
0.7354 Intermediate Similarity NPD6969 Phase 2
0.7354 Intermediate Similarity NPD6968 Phase 2
0.7354 Intermediate Similarity NPD5022 Discontinued
0.7354 Intermediate Similarity NPD7589 Clinical (unspecified phase)
0.7353 Intermediate Similarity NPD3924 Approved
0.7353 Intermediate Similarity NPD3922 Approved
0.7353 Intermediate Similarity NPD3921 Approved
0.7353 Intermediate Similarity NPD3923 Approved
0.7345 Intermediate Similarity NPD3006 Discontinued
0.7337 Intermediate Similarity NPD7414 Clinical (unspecified phase)
0.7336 Intermediate Similarity NPD5067 Phase 2
0.7336 Intermediate Similarity NPD5066 Phase 2
0.7333 Intermediate Similarity NPD6741 Clinical (unspecified phase)
0.7333 Intermediate Similarity NPD1078 Clinical (unspecified phase)
0.7328 Intermediate Similarity NPD4558 Phase 2
0.7327 Intermediate Similarity NPD6393 Clinical (unspecified phase)
0.7319 Intermediate Similarity NPD8246 Approved
0.7319 Intermediate Similarity NPD8247 Approved
0.7318 Intermediate Similarity NPD2285 Clinical (unspecified phase)
0.7318 Intermediate Similarity NPD6824 Clinical (unspecified phase)
0.7315 Intermediate Similarity NPD4897 Phase 2
0.7315 Intermediate Similarity NPD5293 Phase 2
0.7313 Intermediate Similarity NPD7424 Clinical (unspecified phase)
0.7311 Intermediate Similarity NPD7453 Approved
0.7311 Intermediate Similarity NPD7452 Approved
0.7311 Intermediate Similarity NPD1392 Approved
0.7309 Intermediate Similarity NPD7710 Clinical (unspecified phase)
0.7308 Intermediate Similarity NPD3825 Phase 3
0.7304 Intermediate Similarity NPD4440 Clinical (unspecified phase)
0.7295 Intermediate Similarity NPD4899 Clinical (unspecified phase)
0.729 Intermediate Similarity NPD4900 Clinical (unspecified phase)
0.7282 Intermediate Similarity NPD3396 Approved
0.7282 Intermediate Similarity NPD3395 Approved
0.7277 Intermediate Similarity NPD5863 Clinical (unspecified phase)
0.7273 Intermediate Similarity NPD1032 Phase 2
0.7273 Intermediate Similarity NPD4923 Phase 1
0.7264 Intermediate Similarity NPD5083 Clinical (unspecified phase)
0.7264 Intermediate Similarity NPD5530 Phase 1
0.726 Intermediate Similarity NPD3402 Phase 1
0.7256 Intermediate Similarity NPD3570 Phase 2
0.7253 Intermediate Similarity NPD6172 Clinical (unspecified phase)
0.7251 Intermediate Similarity NPD2121 Clinical (unspecified phase)
0.7227 Intermediate Similarity NPD8479 Phase 2
0.7227 Intermediate Similarity NPD5850 Phase 3
0.7225 Intermediate Similarity NPD5999 Phase 2
0.722 Intermediate Similarity NPD5450 Discontinued
0.722 Intermediate Similarity NPD2334 Discontinued
0.7217 Intermediate Similarity NPD3397 Phase 2
0.7212 Intermediate Similarity NPD7796 Approved
0.7212 Intermediate Similarity NPD7797 Approved
0.7202 Intermediate Similarity NPD6643 Discontinued
0.72 Intermediate Similarity NPD1659 Phase 1
0.7196 Intermediate Similarity NPD9595 Approved
0.7196 Intermediate Similarity NPD9596 Approved
0.7194 Intermediate Similarity NPD5320 Approved
0.7194 Intermediate Similarity NPD565 Phase 2
0.7194 Intermediate Similarity NPD5319 Approved
0.7192 Intermediate Similarity NPD5256 Discontinued
0.719 Intermediate Similarity NPD4396 Clinical (unspecified phase)
0.7182 Intermediate Similarity NPD3514 Clinical (unspecified phase)
0.7181 Intermediate Similarity NPD7558 Phase 2
0.7179 Intermediate Similarity NPD4896 Clinical (unspecified phase)
0.7175 Intermediate Similarity NPD4890 Phase 2
0.7171 Intermediate Similarity NPD6281 Approved
0.7167 Intermediate Similarity NPD8100 Phase 3
0.7163 Intermediate Similarity NPD6550 Discontinued
0.7163 Intermediate Similarity NPD5512 Phase 3
0.715 Intermediate Similarity NPD5575 Clinical (unspecified phase)
0.7149 Intermediate Similarity NPD6525 Clinical (unspecified phase)
0.7149 Intermediate Similarity NPD2757 Phase 2
0.7143 Intermediate Similarity NPD7674 Phase 3
0.7143 Intermediate Similarity NPD7676 Clinical (unspecified phase)
0.7143 Intermediate Similarity NPD4118 Clinical (unspecified phase)
0.7143 Intermediate Similarity NPD7069 Discontinued
0.7143 Intermediate Similarity NPD7675 Phase 3
0.7136 Intermediate Similarity NPD5104 Approved
0.7129 Intermediate Similarity NPD6769 Clinical (unspecified phase)
0.7125 Intermediate Similarity NPD5116 Phase 1
0.7123 Intermediate Similarity NPD5612 Discontinued
0.7123 Intermediate Similarity NPD2412 Clinical (unspecified phase)
0.7123 Intermediate Similarity NPD2433 Clinical (unspecified phase)
0.7117 Intermediate Similarity NPD5507 Approved
0.7117 Intermediate Similarity NPD5506 Approved
0.7116 Intermediate Similarity NPD6366 Clinical (unspecified phase)
0.7115 Intermediate Similarity NPD6590 Discontinued
0.7112 Intermediate Similarity NPD6716 Phase 1
0.7111 Intermediate Similarity NPD6553 Clinical (unspecified phase)
0.711 Intermediate Similarity NPD3945 Discontinued
0.7105 Intermediate Similarity NPD4850 Phase 1
0.7104 Intermediate Similarity NPD3763 Approved
0.7104 Intermediate Similarity NPD6500 Approved
0.7104 Intermediate Similarity NPD6501 Approved
0.7103 Intermediate Similarity NPD3003 Approved
0.7103 Intermediate Similarity NPD7001 Phase 3
0.71 Intermediate Similarity NPD6159 Phase 2
0.7097 Intermediate Similarity NPD4131 Phase 3
0.7095 Intermediate Similarity NPD4987 Clinical (unspecified phase)
0.7093 Intermediate Similarity NPD7284 Clinical (unspecified phase)
0.7091 Intermediate Similarity NPD4989 Phase 2
0.7085 Intermediate Similarity NPD8356 Approved
0.7085 Intermediate Similarity NPD9690 Approved
0.7082 Intermediate Similarity NPD3264 Phase 3
0.7078 Intermediate Similarity NPD7538 Clinical (unspecified phase)
0.7076 Intermediate Similarity NPD8101 Phase 3
0.7074 Intermediate Similarity NPD2951 Discontinued
0.7073 Intermediate Similarity NPD6257 Clinical (unspecified phase)
0.7067 Intermediate Similarity NPD802 Phase 2
0.7064 Intermediate Similarity NPD3330 Phase 1
0.7062 Intermediate Similarity NPD2778 Approved
0.7059 Intermediate Similarity NPD3354 Phase 2
0.7059 Intermediate Similarity NPD5632 Approved
0.7059 Intermediate Similarity NPD4926 Clinical (unspecified phase)
0.7059 Intermediate Similarity NPD8405 Clinical (unspecified phase)
0.7059 Intermediate Similarity NPD7405 Clinical (unspecified phase)
0.7059 Intermediate Similarity NPD4353 Phase 2
0.7053 Intermediate Similarity NPD4148 Approved
0.7048 Intermediate Similarity NPD2952 Discontinued
0.7048 Intermediate Similarity NPD5801 Clinical (unspecified phase)
0.7041 Intermediate Similarity NPD2780 Approved
0.7041 Intermediate Similarity NPD2782 Approved
0.7039 Intermediate Similarity NPD6965 Clinical (unspecified phase)
0.7037 Intermediate Similarity NPD2187 Approved
0.7037 Intermediate Similarity NPD2510 Approved
0.7037 Intermediate Similarity NPD2509 Approved
0.7037 Intermediate Similarity NPD2189 Approved
0.7035 Intermediate Similarity NPD8430 Approved
0.7032 Intermediate Similarity NPD5945 Phase 1
0.7032 Intermediate Similarity NPD5944 Phase 1
0.7031 Intermediate Similarity NPD5040 Clinical (unspecified phase)
0.7027 Intermediate Similarity NPD7194 Discontinued
0.7027 Intermediate Similarity NPD7203 Clinical (unspecified phase)
0.7024 Intermediate Similarity NPD4919 Phase 3

Structure

External Identifiers

PubChem CID   483522
ChEMBL   CHEMBL507610
ZINC  

Physicochemical Properties

Molecular Weight:  250.07
ALogP:  -0.3255
MLogP:  2.67
XLogP:  2.365
# Rotatable Bonds:  2
Polar Surface Area:  44.12
# H-Bond Aceptor:  3
# H-Bond Donor:  0
# Rings:  4
# Heavy Atoms:  19

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Biological Activities  
Similar NPs/Drugs