Target ID |
Target Type |
Target Name |
Target Organism |
Activity Type |
Activity Relation |
Value |
Unit |
Reference |
NPT1016 |
Organism |
Canis familiaris |
Canis lupus familiaris |
ED50 |
= |
1 |
mg/kg |
2299628 |
NPT1016 |
Organism |
Canis familiaris |
Canis lupus familiaris |
ED50 |
= |
10 |
mg/kg |
2299628 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
IC50 |
= |
160 |
nM |
11992775 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
IC50 |
= |
4 |
nM |
11992775 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
LD50 |
= |
53.6 |
mg/kg |
6147415 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
LD50 |
= |
524 |
umol/kg |
7359535 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
ED50 |
= |
122 |
umol/kg |
7359535 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
Ratio |
= |
4.3 |
|
7359535 |
NPT938 |
Organism |
Cavia porcellus |
Cavia porcellus |
Activity |
= |
1.15 |
|
7359531 |
NPT212 |
Individual Protein |
Cytochrome P450 2C9 |
Homo sapiens |
Ki |
= |
32000 |
nM |
14761192 |
NPT1774 |
Protein Family |
Sodium channel alpha subunits; brain (Types I, II, III) |
Homo sapiens |
IC50 |
= |
3200 |
nM |
2579237 |
NPT1774 |
Protein Family |
Sodium channel alpha subunits; brain (Types I, II, III) |
Homo sapiens |
Inhibition |
= |
74.1 |
% |
2579237 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Ki |
= |
80 |
nM |
8487254 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Ki |
= |
40 |
nM |
8487254 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Ki |
= |
43 |
nM |
8487254 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Ki |
= |
60 |
nM |
8487254 |
NPT938 |
Organism |
Cavia porcellus |
Cavia porcellus |
EC30 |
= |
7.2 |
ug/ml |
7452671 |
NPT938 |
Organism |
Cavia porcellus |
Cavia porcellus |
EC30 |
= |
62 |
ug/ml |
7452671 |
NPT938 |
Organism |
Cavia porcellus |
Cavia porcellus |
EC30 |
= |
6.5 |
ug/ml |
7452671 |
NPT2 |
Others |
Unspecified |
|
Ratio |
= |
8.6 |
|
7452671 |
NPT2 |
Others |
Unspecified |
|
Ratio |
= |
0.9 |
|
7452671 |
NPT2859 |
Individual Protein |
Cytochrome P450 2D1 |
Rattus norvegicus |
IC50 |
= |
19900 |
nM |
12502361 |
NPT2860 |
Individual Protein |
Cytochrome P450 2D2 |
Rattus norvegicus |
IC50 |
= |
2800 |
nM |
12502361 |
NPT2861 |
Individual Protein |
Cytochrome P450 2D3 |
Rattus norvegicus |
IC50 |
= |
26900 |
nM |
12502361 |
NPT2862 |
Individual Protein |
Cytochrome P450 2D18 |
Rattus norvegicus |
IC50 |
= |
47200 |
nM |
12502361 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
3.3 |
nM |
12502361 |
NPT938 |
Organism |
Cavia porcellus |
Cavia porcellus |
Inhibition |
= |
62 |
% |
6384519 |
NPT938 |
Organism |
Cavia porcellus |
Cavia porcellus |
Kd |
= |
1000 |
nM |
6384519 |
NPT5601 |
Individual Protein |
Sodium channel protein type V alpha subunit |
Rattus norvegicus |
Inhibition |
= |
68 |
% |
8230126 |
NPT2 |
Others |
Unspecified |
|
Inhibition |
= |
40 |
% |
8230126 |
NPT938 |
Organism |
Cavia porcellus |
Cavia porcellus |
ED20 |
= |
7.2 |
mg/kg |
8230126 |
NPT938 |
Organism |
Cavia porcellus |
Cavia porcellus |
Inhibition |
= |
62 |
% |
3973901 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
LD50 |
= |
89 |
mg/kg |
7205883 |
NPT98 |
Individual Protein |
HERG |
Homo sapiens |
IC50 |
= |
323.59 |
nM |
12873512 |
NPT109 |
Individual Protein |
Cytochrome P450 3A4 |
Homo sapiens |
IC50 |
> |
50000 |
nM |
12699389 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
Activity |
= |
20 |
nM/mg*min |
12699389 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
Inhibition |
= |
36 |
% |
12699389 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
IC50 |
= |
2200 |
nM |
12699389 |
NPT1455 |
Individual Protein |
P-glycoprotein 3 |
Mus musculus |
IC50 |
= |
13000 |
nM |
12699389 |
NPT1456 |
Individual Protein |
P-glycoprotein 1 |
Mus musculus |
IC50 |
= |
10000 |
nM |
12699389 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
IC50 |
= |
5600 |
nM |
12699389 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
LD50 |
= |
175 |
mg/kg |
3572966 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
LD50 |
= |
48 |
mg/kg |
3572966 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
ED50 |
= |
4.7 |
mg/kg |
3572966 |
NPT419 |
Organism |
Oryctolagus cuniculus |
Oryctolagus cuniculus |
EC30 |
= |
3.9 |
ug/ml |
3572966 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
ED50 |
= |
13.5 |
mg/kg |
3572966 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
ED50 |
= |
3.2 |
mg/kg |
3572966 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
ED50 |
= |
47.7 |
mg/kg |
3572966 |
NPT1016 |
Organism |
Canis familiaris |
Canis lupus familiaris |
ED50 |
= |
1 |
mg/kg |
3572966 |
NPT1016 |
Organism |
Canis familiaris |
Canis lupus familiaris |
ED50 |
= |
5.5 |
mg/kg |
3572966 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
ED50 |
= |
15.2 |
mg/kg |
3572966 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
ED50 |
= |
14 |
mg/kg |
3572966 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
ED50 |
= |
122 |
mg/kg |
3572966 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
ED50 |
= |
158 |
mg/kg |
3572966 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
-30 |
% |
3572966 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
-36 |
% |
3572966 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
3 |
% |
3572966 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
EC50 |
= |
0.0098 |
ug/ml |
3572966 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
Ki |
= |
2600 |
nM |
12477351 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
IC50 |
= |
340000 |
nM |
12477351 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
Ki |
= |
5000 |
nM |
12477351 |
NPT2 |
Others |
Unspecified |
|
IC50 |
= |
240000 |
nM |
15225721 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
10 |
nM |
15481972 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Ki |
= |
30 |
nM |
15481972 |
NPT98 |
Individual Protein |
HERG |
Homo sapiens |
IC50 |
= |
323.59 |
nM |
15911273 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
20 |
nM |
16570918 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
69 |
% |
17228875 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
71 |
% |
17228875 |
NPT2744 |
Tissue |
Aorta |
Cavia porcellus |
Inhibition |
= |
30 |
% |
17228875 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
86 |
% |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
160 |
|
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
153 |
|
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
140 |
|
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
123 |
|
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
107 |
|
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
53 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
25 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
54 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
27 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
170 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
57 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
31 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
60 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
35 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
200 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
70 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
39 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
229 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
158 |
ms |
17228875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
182 |
ms |
17228875 |
NPT2 |
Others |
Unspecified |
|
EC50 |
= |
10260 |
nM |
17228875 |
NPT2 |
Others |
Unspecified |
|
EC50 |
= |
3380 |
nM |
17228875 |
NPT2 |
Others |
Unspecified |
|
EC50 |
= |
3990 |
nM |
17228875 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
410 |
nM |
17249648 |
NPT2249 |
Individual Protein |
Histidine-rich protein |
Plasmodium falciparum |
IC50 |
= |
325000 |
nM |
17088494 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
2.3 |
micromol/kg/min |
17506538 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
317 |
umol/kg |
17506538 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
LD50 |
= |
100 |
umol/kg |
17506538 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
ED50 |
= |
4 |
micromol/kg/min |
17506538 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
3 |
micromol/kg/min |
17506538 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
1.5 |
micromol/kg/min |
17506538 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
2.5 |
micromol/kg/min |
17506538 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
1.1 |
micromol/kg/min |
17506538 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
3.2 |
micromol/kg/min |
17506538 |
NPT2856 |
Individual Protein |
Sodium channel protein type V alpha subunit |
Homo sapiens |
IC50 |
= |
6900 |
nM |
17506538 |
NPT3839 |
Individual Protein |
Voltage-gated potassium channel subunit Kv1.5 |
Homo sapiens |
IC50 |
= |
7300 |
nM |
17506538 |
NPT5602 |
Individual Protein |
Potassium voltage-gated channel subfamily D member 2 |
Rattus norvegicus |
IC50 |
= |
2200 |
nM |
17506538 |
NPT3035 |
Cell Line |
ScN2a |
Mus musculus |
IC50 |
= |
5000 |
nM |
17850126 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
11 |
nM |
18324762 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
14 |
nM |
18672861 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
78 |
nM |
15270556 |
NPT612 |
Individual Protein |
Canalicular multispecific organic anion transporter 1 |
Homo sapiens |
Activity |
= |
64 |
% |
18457386 |
NPT98 |
Individual Protein |
HERG |
Homo sapiens |
IC50 |
= |
323.59 |
nM |
18448342 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
14 |
nM |
18763754 |
NPT613 |
Individual Protein |
Solute carrier family 22 member 1 |
Homo sapiens |
IC50 |
= |
113800 |
nM |
18788725 |
NPT613 |
Individual Protein |
Solute carrier family 22 member 1 |
Homo sapiens |
Inhibition |
= |
62.9 |
% |
18788725 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Inhibition |
= |
90 |
% |
19326942 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
19.6 |
nM |
19117415 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Ki |
= |
9.8 |
nM |
19117415 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Activity |
= |
0 |
% |
17132069 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
82 |
nM |
15679319 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
14000 |
nM |
19049427 |
NPT938 |
Organism |
Cavia porcellus |
Cavia porcellus |
EC50 |
= |
8.34 |
umol/kg |
18262683 |
NPT938 |
Organism |
Cavia porcellus |
Cavia porcellus |
EC50 |
= |
2818382.93 |
nM |
18262683 |
NPT485 |
Organism |
Plasmodium falciparum (isolate K1 / Thailand) |
Plasmodium falciparum K1 |
IC50 |
= |
51 |
nM |
18395298 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
Inhibition |
= |
98 |
% |
20485427 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
Inhibition |
= |
0 |
% |
20485427 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
Inhibition |
= |
95 |
% |
20485427 |
NPT65 |
Cell Line |
HepG2 |
Homo sapiens |
Inhibition |
= |
0 |
% |
20485427 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
EC50 |
= |
35.2 |
nM |
18579783 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
EC50 |
= |
9.59 |
nM |
18579783 |
NPT1229 |
Cell Line |
Huh-7 |
Homo sapiens |
CC50 |
= |
50750 |
nM |
18579783 |
NPT605 |
Organism |
Homo sapiens |
Homo sapiens |
Activity |
= |
0.81 |
% |
20022146 |
NPT2 |
Others |
Unspecified |
|
EC50 |
= |
3380 |
nM |
20509610 |
NPT2 |
Others |
Unspecified |
|
EC50 |
= |
3990 |
nM |
20509610 |
NPT2744 |
Tissue |
Aorta |
Cavia porcellus |
Inhibition |
= |
30 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
182 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
200 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
229 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
170 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
158 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
39 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
35 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
31 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
27 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
25 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
70 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
60 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
57 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
54 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
53 |
% |
20509610 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
107 |
% |
20509610 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
123 |
% |
20509610 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
140 |
% |
20509610 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
153 |
% |
20509610 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
160 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
69 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
EC50 |
= |
10260 |
nM |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
71 |
% |
20509610 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
86 |
% |
20509610 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
IC50 |
= |
24000 |
nM |
20185316 |
NPT312 |
Organism |
Saccharomyces cerevisiae |
Saccharomyces cerevisiae |
IZ |
= |
8 |
mm |
20739103 |
NPT210 |
Individual Protein |
Thyroid stimulating hormone receptor |
Homo sapiens |
Potency |
= |
25118.9 |
nM |
PubChem BioAssay data set |
NPT50 |
Individual Protein |
Tyrosyl-DNA phosphodiesterase 1 |
Homo sapiens |
Potency |
= |
31.6 |
nM |
PubChem BioAssay data set |
NPT94 |
Individual Protein |
Aldehyde dehydrogenase 1A1 |
Homo sapiens |
Potency |
= |
12589.3 |
nM |
PubChem BioAssay data set |
NPT56 |
Individual Protein |
Beta-lactamase AmpC |
Escherichia coli K-12 |
Potency |
= |
8912.5 |
nM |
PubChem BioAssay data set |
NPT347 |
Cell Line |
Lymphoblastoid cells |
Homo sapiens |
Potency |
= |
63095.7 |
nM |
PubChem BioAssay data set |
NPT2 |
Others |
Unspecified |
|
Potency |
= |
12589.3 |
nM |
PubChem BioAssay data set |
NPT109 |
Individual Protein |
Cytochrome P450 3A4 |
Homo sapiens |
Potency |
= |
15848.9 |
nM |
PubChem BioAssay data set |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
10 |
nM |
21189020 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
10 |
nM |
21138310 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
14 |
nM |
21384875 |
NPT98 |
Individual Protein |
HERG |
Homo sapiens |
Inhibition |
= |
85.5 |
% |
21752640 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
Potency |
|
20.8 |
nM |
PubChem BioAssay data set |
NPT98 |
Individual Protein |
HERG |
Homo sapiens |
Potency |
|
7943.3 |
nM |
PubChem BioAssay data set |
NPT2 |
Others |
Unspecified |
|
Potency |
|
1258.9 |
nM |
PubChem BioAssay data set |
NPT99 |
Individual Protein |
Peroxisome proliferator-activated receptor gamma |
Homo sapiens |
Potency |
|
44668.4 |
nM |
PubChem BioAssay data set |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
Potency |
|
29.4 |
nM |
PubChem BioAssay data set |
NPT2 |
Others |
Unspecified |
|
Potency |
|
35.5 |
nM |
PubChem BioAssay data set |
NPT2 |
Others |
Unspecified |
|
Potency |
|
25.1 |
nM |
PubChem BioAssay data set |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
86 |
% |
22191686 |
NPT2 |
Others |
Unspecified |
|
EC50 |
= |
10260 |
nM |
22191686 |
NPT2 |
Others |
Unspecified |
|
Activity |
= |
71 |
% |
22191686 |
NPT2 |
Others |
Unspecified |
|
EC50 |
= |
3380 |
nM |
22191686 |
NPT2 |
Others |
Unspecified |
|
EC30 |
= |
3.99 |
nM |
22191686 |
NPT2744 |
Tissue |
Aorta |
Cavia porcellus |
Activity |
= |
30 |
% |
22191686 |
NPT2 |
Others |
Unspecified |
|
IC50 |
= |
130000 |
nM |
22512909 |
NPT2 |
Others |
Unspecified |
|
IC50 |
= |
23000 |
nM |
22512909 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
IC50 |
= |
18 |
nM |
22512909 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
IC50 |
= |
90 |
nM |
22512909 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
Inhibition |
= |
21.1 |
% |
24900460 |
NPT2794 |
Individual Protein |
Quinolone resistance protein norA |
Staphylococcus aureus |
Inhibition |
= |
31.5 |
% |
24900460 |
NPT213 |
Individual Protein |
Cytochrome P450 2C19 |
Homo sapiens |
Ratio IC50 |
= |
2 |
|
22931300 |
NPT434 |
Individual Protein |
Solute carrier family 22 member 5 |
Mus musculus |
Activity |
= |
6.1 |
% |
11160873 |
NPT73 |
Individual Protein |
Solute carrier organic anion transporter family member 1B1 |
Homo sapiens |
Activity |
= |
81 |
% |
12906759 |
NPT705 |
Individual Protein |
Solute carrier family 22 member 5 |
Homo sapiens |
Activity |
= |
9.1 |
% |
10525100 |
NPT4360 |
Individual Protein |
Solute carrier family 22 member 1 |
Mus musculus |
Activity |
= |
0 |
% |
11060354 |
NPT1543 |
Individual Protein |
Solute carrier family 22 member 4 |
Homo sapiens |
Activity |
= |
15.2 |
% |
10215651 |
NPT613 |
Individual Protein |
Solute carrier family 22 member 1 |
Homo sapiens |
Activity |
= |
20 |
% |
15716364 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
Activity |
= |
36 |
% |
12699389 |
NPT1733 |
Individual Protein |
Solute carrier organic anion transporter family member 1A2 |
Homo sapiens |
Activity |
= |
91 |
% |
10421612 |
NPT613 |
Individual Protein |
Solute carrier family 22 member 1 |
Homo sapiens |
Activity |
= |
5.4 |
nM |
12606755 |
NPT435 |
Individual Protein |
Solute carrier family 22 member 1 |
Rattus norvegicus |
IC50 |
= |
12700 |
nM |
11502595 |
NPT1544 |
Individual Protein |
Solute carrier family 22 member 2 |
Rattus norvegicus |
IC50 |
= |
14600 |
nM |
11502595 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
IC50 |
= |
18800 |
nM |
11716514 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
IC50 |
= |
1000 |
nM |
11716514 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
IC50 |
= |
2200 |
nM |
10820137 |
NPT613 |
Individual Protein |
Solute carrier family 22 member 1 |
Homo sapiens |
IC50 |
= |
23400 |
nM |
10027858 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
IC50 |
= |
33800 |
nM |
12649369 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
IC50 |
= |
33900 |
nM |
11716514 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
Ki |
= |
430 |
nM |
12636153 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
Ki |
= |
1500 |
nM |
11405287 |
NPT305 |
Individual Protein |
Solute carrier organic anion transporter family member 1A4 |
Rattus norvegicus |
Ki |
= |
120000 |
nM |
11883641 |
NPT435 |
Individual Protein |
Solute carrier family 22 member 1 |
Rattus norvegicus |
Ki |
= |
14600 |
nM |
9808712 |
NPT613 |
Individual Protein |
Solute carrier family 22 member 1 |
Homo sapiens |
Ki |
= |
17500 |
nM |
9655880 |
NPT1544 |
Individual Protein |
Solute carrier family 22 member 2 |
Rattus norvegicus |
Ki |
= |
19100 |
nM |
9808712 |
NPT435 |
Individual Protein |
Solute carrier family 22 member 1 |
Rattus norvegicus |
Ki |
= |
6000 |
nM |
8878062 |
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
Ki |
= |
8590 |
nM |
12134945 |
NPT752 |
Individual Protein |
Solute carrier organic anion transporter family member 1A1 |
Rattus norvegicus |
Ki |
= |
9270 |
nM |
11883641 |
NPT152 |
Individual Protein |
Nuclear factor erythroid 2-related factor 2 |
Homo sapiens |
Potency |
|
14960.1 |
nM |
PubChem BioAssay data set |
NPT478 |
Individual Protein |
Ataxin-2 |
Homo sapiens |
Potency |
|
35481.3 |
nM |
PubChem BioAssay data set |
NPT101 |
Individual Protein |
Glucagon-like peptide 1 receptor |
Homo sapiens |
Potency |
|
17782.8 |
nM |
PubChem BioAssay data set |
NPT622 |
Individual Protein |
Solute carrier organic anion transporter family member 2B1 |
Homo sapiens |
Inhibition |
= |
-10 |
% |
22541068 |
NPT72 |
Individual Protein |
Solute carrier organic anion transporter family member 1B3 |
Homo sapiens |
Inhibition |
= |
37.2 |
% |
22541068 |
NPT73 |
Individual Protein |
Solute carrier organic anion transporter family member 1B1 |
Homo sapiens |
Inhibition |
= |
43.3 |
% |
22541068 |
NPT439 |
Individual Protein |
Butyrylcholinesterase |
Homo sapiens |
IC50 |
= |
1230 |
nM |
23062825 |
NPT67 |
Individual Protein |
Cholinesterase |
Equus caballus |
IC50 |
= |
7370 |
nM |
23062825 |
NPT485 |
Organism |
Plasmodium falciparum (isolate K1 / Thailand) |
Plasmodium falciparum K1 |
IC50 |
= |
51 |
nM |
10.1007/s00044-007-9025-8 |
NPT757 |
Organism |
Plasmodium falciparum 3D7 |
Plasmodium falciparum 3D7 |
IC50 |
= |
21 |
nM |
10.1007/s00044-007-9025-8 |
NPT2 |
Others |
Unspecified |
|
IC50 |
= |
24000 |
nM |
10.1007/s00044-007-9025-8 |
NPT992 |
Organism |
Entamoeba histolytica |
Entamoeba histolytica |
IC50 |
= |
16.6 |
ug/ml |
10.1007/s00044-011-9767-1 |
NPT4037 |
Individual Protein |
Multidrug and toxin extrusion protein 1 |
Homo sapiens |
Inhibition |
= |
28 |
% |
23241029 |
NPT4037 |
Individual Protein |
Multidrug and toxin extrusion protein 1 |
Homo sapiens |
IC50 |
= |
11200 |
nM |
23241029 |
NPT857 |
Cell Line |
LLC-PK1 |
Sus scrofa |
Ratio |
= |
7.4 |
|
24900570 |
NPT2 |
Others |
Unspecified |
|
Potency |
|
23109.3 |
nM |
PubChem BioAssay data set |
NPT2 |
Others |
Unspecified |
|
Potency |
|
12995.3 |
nM |
PubChem BioAssay data set |
NPT2 |
Others |
Unspecified |
|
Ratio IC50 |
= |
1.3 |
|
23816880 |
NPT471 |
Organism |
Trypanosoma brucei brucei |
Trypanosoma brucei brucei |
IC50 |
= |
8.42 |
ug/ml |
23816880 |
NPT1374 |
Cell Line |
WI-38 |
Homo sapiens |
IC50 |
= |
11.28 |
ug/ml |
23816880 |
NPT2 |
Others |
Unspecified |
|
Ratio IC50 |
= |
179.1 |
|
23816880 |
NPT6 |
Organism |
Plasmodium falciparum |
Plasmodium falciparum |
IC50 |
= |
0.06 |
ug/ml |
23816880 |
NPT3694 |
Organism |
Leishmania mexicana mexicana |
Leishmania mexicana mexicana |
IC50 |
> |
20 |
ug/ml |
23816880 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
2 |
nM |
24050112 |
NPT109 |
Individual Protein |
Cytochrome P450 3A4 |
Homo sapiens |
Inhibition |
= |
36 |
% |
24079662 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Inhibition |
= |
90 |
% |
24079662 |
NPT208 |
Individual Protein |
Cytochrome P450 1A2 |
Homo sapiens |
Inhibition |
= |
23 |
% |
24079662 |
NPT212 |
Individual Protein |
Cytochrome P450 2C9 |
Homo sapiens |
Inhibition |
= |
9 |
% |
24079662 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Inhibition |
= |
95.07 |
% |
24900814 |
NPT2 |
Others |
Unspecified |
|
Potency |
|
31622.8 |
nM |
PubChem BioAssay data set |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
50.6 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
51.6 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
52.9 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
54.4 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
54.6 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
20.3 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
24.2 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
26.1 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
27.6 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
28.2 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
76.3 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
85.8 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
88.3 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
91.3 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
90.6 |
min |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
311.8 |
bpm |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
285.16 |
bpm |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
246.18 |
bpm |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
261.63 |
bpm |
24637077 |
NPT29 |
Organism |
Rattus norvegicus |
Rattus norvegicus |
Activity |
= |
286.32 |
bpm |
24637077 |
NPT1016 |
Organism |
Canis familiaris |
Canis lupus familiaris |
Activity |
= |
25 |
% |
845875 |
NPT1016 |
Organism |
Canis familiaris |
Canis lupus familiaris |
Activity |
= |
46 |
% |
845875 |
NPT1016 |
Organism |
Canis familiaris |
Canis lupus familiaris |
Activity |
= |
89 |
% |
845875 |
NPT1016 |
Organism |
Canis familiaris |
Canis lupus familiaris |
Activity |
= |
21 |
bpm |
845875 |
NPT1016 |
Organism |
Canis familiaris |
Canis lupus familiaris |
Activity |
= |
24 |
bpm |
845875 |
NPT1016 |
Organism |
Canis familiaris |
Canis lupus familiaris |
Activity |
= |
31 |
bpm |
845875 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
-36.3 |
% |
1255662 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
-22.8 |
% |
1255662 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
-13.3 |
% |
1255662 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
-36.1 |
% |
1255662 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
-28.6 |
% |
1255662 |
NPT3707 |
Tissue |
Heart |
Cavia porcellus |
Activity |
= |
-18.8 |
% |
1255662 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
ED50 |
= |
0.16 |
uM/ml |
1255662 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
LD50 |
= |
0.533 |
uM/ml |
1255662 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
Ratio LD50/ED50 |
= |
3.3 |
|
1255662 |
NPT32 |
Organism |
Mus musculus |
Mus musculus |
ED50 |
= |
217 |
umol/kg |
874956 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
17 |
nM |
24793360 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
25000 |
nM |
24974340 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Inhibition |
= |
21.2 |
% |
24974340 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
< |
6 |
nM |
25082126 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
25100 |
nM |
25221656 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
120 |
nM |
25300820 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Inhibition |
= |
88 |
% |
25244572 |
NPT98 |
Individual Protein |
HERG |
Homo sapiens |
Inhibition |
= |
100 |
% |
25654185 |
NPT2856 |
Individual Protein |
Sodium channel protein type V alpha subunit |
Homo sapiens |
IC50 |
= |
16600 |
nM |
21300721 |
NPT1305 |
Individual Protein |
Voltage-dependent L-type calcium channel subunit alpha-1C |
Cavia porcellus |
IC50 |
= |
15600 |
nM |
21300721 |
NPT98 |
Individual Protein |
HERG |
Homo sapiens |
IC50 |
= |
300 |
nM |
21300721 |
NPT1305 |
Individual Protein |
Voltage-dependent L-type calcium channel subunit alpha-1C |
Cavia porcellus |
IC50 |
= |
15600 |
nM |
22761000 |
NPT2691 |
Individual Protein |
Voltage-gated L-type calcium channel alpha-1C subunit |
Homo sapiens |
IC50 |
= |
19820 |
nM |
22761000 |
NPT2719 |
Individual Protein |
Voltage-gated L-type calcium channel alpha-1C subunit |
Rattus norvegicus |
IC50 |
= |
10000 |
nM |
22761000 |
NPT2 |
Others |
Unspecified |
|
IC50 |
= |
6400 |
nM |
23812503 |
NPT2 |
Others |
Unspecified |
|
Ratio |
= |
0.05 |
|
22899853 |
NPT2 |
Others |
Unspecified |
|
Ratio |
= |
0.22 |
|
22899853 |
NPT317 |
Uncleic Acid |
Nucleic Acid |
|
Ratio |
= |
0.23 |
|
22899853 |
NPT1543 |
Individual Protein |
Solute carrier family 22 member 4 |
Homo sapiens |
Inhibition |
= |
83.9 |
% |
23073734 |
NPT705 |
Individual Protein |
Solute carrier family 22 member 5 |
Homo sapiens |
Inhibition |
= |
89.9 |
% |
23073734 |
NPT2 |
Others |
Unspecified |
|
IC50 |
= |
34810 |
nM |
26063305 |
NPT471 |
Organism |
Trypanosoma brucei brucei |
Trypanosoma brucei brucei |
IC50 |
= |
25990 |
nM |
26063305 |
NPT2 |
Others |
Unspecified |
|
Ratio IC50 |
= |
1.3 |
|
26063305 |
NPT757 |
Organism |
Plasmodium falciparum 3D7 |
Plasmodium falciparum 3D7 |
IC50 |
= |
194.4 |
nM |
26063305 |
NPT2 |
Others |
Unspecified |
|
Ratio IC50 |
= |
179.1 |
|
26063305 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Inhibition |
= |
96.25 |
% |
26096679 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
18 |
nM |
26204510 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
30 |
nM |
26355532 |
NPT2719 |
Individual Protein |
Voltage-gated L-type calcium channel alpha-1C subunit |
Rattus norvegicus |
IC50 |
= |
5600 |
nM |
|
NPT668 |
Individual Protein |
P-glycoprotein 1 |
Homo sapiens |
Ratio |
= |
7.81 |
|
26741854 |
NPT616 |
Cell Line |
MDCK |
Canis lupus familiaris |
Ratio |
= |
2.34 |
|
26741854 |
NPT98 |
Individual Protein |
HERG |
Homo sapiens |
IC50 |
= |
2670 |
nM |
26640981 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
17 |
nM |
27105029 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Inhibition |
= |
96.25 |
% |
27229618 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
9 |
nM |
26962886 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
Inhibition |
= |
93 |
% |
27050842 |
NPT110 |
Individual Protein |
Cytochrome P450 2D6 |
Homo sapiens |
IC50 |
= |
60 |
nM |
27145071 |