TCM Prescription: Pei Kun Pills



Prescription Description
Prescription IDTCMF989
Pinyin NamePei Kun Wan 
Chinese Name培坤丸
English NamePei Kun Pills
Function Description妇人月经不调, 赤白带下, 子宫炎, 身困肢懒, 腹痛肢冷各症
IndicationsAbdominal pain disorder, Irregular menstruation, Inflammatory disease of uterus
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
GA01.Z [Inflammatory disorders of the uterus, except cervix, unspecified, 子宫炎症性疾患，除宫颈外，未特指的 ];
Human Tissues Associated with IndicationUterus
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH147 Glehnia littoralis 北沙参 TCMH147 ITSAF389-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH525 Eucommia ulmoides 杜仲炭 TCMH525 ITSAM1588-14
TCMH1329 Arillus longan 龙眼肉 TCMH1329
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH820 Semen juglandis 核桃 TCMH820
TCMH11 Blumea balsamifera 艾炭 TCMH11 ITSAP1543-14
TCMH2375 Trigonella foenum-graecum 盐胡芦巴 TCMH2375 PSUPP015-15
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH1862 Cornus officinalis 山茱萸 TCMH1862 ITSAO2979-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TEK, TRPV1, TYR 13.6971
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 13.335
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PRKCB, PRKCD, PRKCE, RORC, SRC, TEK, TRPV1, TYR 13.2726
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TEK, TRPV1, TYR 11.503
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.001
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.9867
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 10.9625
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.9282
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.99779
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 9.87611
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, TRPV1 9.87611
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.8499
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.67353
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 9.41543
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.24309
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.13463
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 9.10717
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 9.04003
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, NR3C1, PRKCE, RORC, SRC, TYR 8.84157
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.81436
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, NR3C1, PPARA, PRKCD, PRKCE, SMAD3, SRC, TEK, TRPV1 8.76771
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, NR3C1, PPARA, PRKCD, PRKCE, SRC, TEK, TRPV1 8.7137
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.66828
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GBA2, HMGCR, HSPA1A, IDO1, PIM1, PPARA, TYR, XDH 8.61556
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 8.56493
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, SMAD3, SRC, TEK, XDH 8.43384
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TRPV1 8.30833
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK 8.30438
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK 8.26452
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, PRKCA, PRKCB, PRKCE, PTPN1, SRC, TEK, XDH 8.10317
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, PRKCE, PRKCG, RORC, SRC, TEK, TRPV1, TYR 8.05932
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 8.05932
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PRKCB, PRKCD, PRKCE, RORC, SMAD3, SRC, TRPV1 8.05116
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PRKCG, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR 7.87324
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, NR3C1, PRKCB, PRKCD, PRKCE, RORC, SMAD3, SRC, TRPV1 7.77308
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, PRKCA, PRKCD, PRKCG, PTPN1, SMAD3, SRC, TEK 7.65674
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 7.5335
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCE 7.08853
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 7.08853
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 6.97185
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, TYR 6.91695
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CDK6, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 6.85858
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.80261
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 6.59989
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, TYR, XDH 6.56633
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 6.53833
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 6.5352
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.45674
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 6.43167
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.38756
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, PRKCB, PRKCD, PRKCE, RORC, SRC, TRPV1 6.26505
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 6.22022
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 6.22022
[BP] GO:0030335 positive regulation of cell migration ALOX12, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 6.20391
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 6.15803
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, TNKS, XDH 6.12746
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 6.12746
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 6.12746
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PRKCB, PRKCD, PRKCE, PTPN1, RORC, SMAD3, SRC, TRPV1 6.07523
[BP] GO:2000147 positive regulation of cell motility ALOX12, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 6.03811
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, TEK 5.97113
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.9265
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.90681
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.89437
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 5.87272
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 5.87272
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, EGFR, HCAR2, HMGCR, KDR, PRKCE, SRC, TNKS, TNKS2, TRPV1 5.85953
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 5.85569
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 5.85569
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.85512
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 5.81748
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HCAR2, HMGCR, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, SLC1A1, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 5.77126
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, TNKS, XDH 5.74877
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSD11B2, KDR, NR3C1, PRKCD, PRKCE, PRKCG, SRC, TRPV1 5.74318
[BP] GO:0040017 positive regulation of locomotion ALOX12, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, SMAD3, SRC, TEK 5.74318
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 5.7047
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PRKCB, PRKCE, SMAD3, SRC, TRPV1 5.61806
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.60441
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PRKCB, PRKCE, SMAD3, TRPV1 5.59146
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 5.5669
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.54344
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.53171
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSPA1A, INSR, MMP12, MMP9, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TRPV1 5.53171
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCE 5.49847
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCE 5.49847
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.49675
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA 5.49675
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.49181
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 5.45072
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.44713
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 5.42589
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, EGFR, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, SMAD3, TEK 5.42589
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.41249
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, IDO1, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, SLC1A1, SMAD3, SRC, TEK, TRPV1 5.36138
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 5.34007
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.27984
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, SRC 5.26692
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HMGCR, HSD11B2, HSPA1A, MMP2, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK, TRPV1, TYR 5.24928
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 5.22844
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK 5.22246
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.19873
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.17343
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK 5.09705
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.05511
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CDK6, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 5.01517
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TRPV1, XDH 4.97953
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 4.96476
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 4.92897
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 4.91116
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.91116
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TNKS 4.91116
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1, TYR 4.91116
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 4.91116
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, EGFR, KDR, NR3C1, PRKCD, PRKCE, SRC, TRPV1 4.8948
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.82755
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 4.79872
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, SMAD3, SRC, TEK 4.7738
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PRKCD, PRKCE, RORC, SRC, TEK 4.73698
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 4.72686
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.72059
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 4.62978
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.6209
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 4.55459
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 4.48767
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1, TYR 4.48386
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 4.40445
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 4.39591
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.36724
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, PRKCE, SRC, TNKS, TNKS2, TRPV1 4.30756
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.30445
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, XDH 4.30332
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 4.27628
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.26893
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.25967
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSPA1A, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 4.25649
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, HMGCR, TYR 4.18718
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PRKCD, PTPN1, SRC 4.16821
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TEK 4.15721
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.15721
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 4.10952
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.10188
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 4.0821
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, HSD11B2, IGF1R, INSR, PPARA, PRKCD, SRC, TEK, TRPV1 4.0749
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK 4.06608
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.06424
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.06139
[BP] GO:0030168 platelet activation AXL, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.01459
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 3.92549
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.91398
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 3.90635
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCD, RORC, SMAD3, SRC, TEK, TNKS2, TYR 3.89746
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.8932
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 3.88339
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.85335
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, SMAD3, TRPV1, XDH 3.85083
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.7599
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.75768
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.74479
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTPN1, SMAD3, SRC, XDH 3.74023
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, IDO1, MMP12, MMP2, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 3.73758
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.73279
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTPN1, SMAD3, SRC, XDH 3.72562
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PRKCE, SRC, TEK 3.72537
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.7249
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 3.7249
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.69894
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.69036
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 3.69036
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, SRC, TEK 3.69036
[BP] GO:0051172 None AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 3.68566
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 3.67014
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 3.63706
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, PPARA 3.61285
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 3.5932
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.58649
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 3.56348
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, PRKCD, PRKCE, SRC 3.55772
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PRKCE, SMAD3, SRC, TEK 3.55772
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, INSR, KDR, MMP9, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 3.55772
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 3.55578
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK 3.53727
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.49551
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.49551
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PRKCD, PRKCE, SMAD3, SRC, TRPV1 3.47812
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, BCL2, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 3.4748
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.47345
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, SMAD3, TRPV1, XDH 3.42868
[BP] GO:0010676 None ESRRB, INSR, PPARA, PRKCE, SRC 3.39841
[BP] GO:0050994 None ADORA1, HCAR2, PPARA, PRKCD, PRKCE 3.39841
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.39783
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PRKCD, PTPN1, SRC, TEK, TNKS 3.38996
[BP] GO:0061041 regulation of wound healing ALOX12, F3, HMGCR, PRKCA, PRKCD, PRKCE, SMAD3 3.35691
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.35238
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PRKCD, SMAD3, SRC, TRPV1, XDH 3.3422
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTPN1, SRC, XDH 3.32801
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 3.3111
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, HMGCR, KDR, PRKCA, PTPN1, SRC, TEK 3.30923
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PRKCD, SMAD3, SRC, TRPV1, XDH 3.30465
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, RORC, SRC, TRPV1 3.29581
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 3.28691
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, PRKCE, SRC, TRPV1 3.28477
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, EGFR, HSPA1A, IDO1 3.25047
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, PRKCG, RORC, SRC 3.20192
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.17679
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PRKCA, PRKCB, TEK 3.17679
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1, SRC 3.16506
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.16506
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 3.16506
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PRKCB, PRKCE, SLC1A1, TRPV1 3.16406
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, NR3C1, SRC 3.14687
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.14687
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 3.12675
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PRKCD, PTPN1, SRC, TEK 3.12558
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.12432
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.09297
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 3.09297
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, PRKCE, SMAD3, TEK 3.08584
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 3.06987
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.06693
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR, TYR 3.06557
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, PRKCD, SRC, TEK, TYR 3.05945
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.05809
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05809
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.0541
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TNKS 3.03322
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, IDO1, MMP9, PRKCD, SMAD3, SRC, TRPV1, XDH 3.02075
[BP] GO:0050730 None ADORA1, EGFR, FLT3, GRM5, PRKCD, PRKCE, PTPN1, SRC 3.01289
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.99668
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PRKCD, SMAD3, TEK 2.98639
[BP] GO:1903034 regulation of response to wounding ALOX12, F3, HMGCR, PRKCA, PRKCD, PRKCE, SMAD3 2.98326
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, PRKCE 2.97216
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.94691
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, PRKCD, SMAD3, TEK 2.94049
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 2.93974
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.92604
[BP] GO:0045913 None ESRRB, INSR, PPARA, PRKCE, SRC 2.92376
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PRKCD, SMAD3, TEK 2.92228
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 2.91416
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.91331
[BP] GO:0050793 regulation of developmental process ALOX12, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, IDO1, INSR, KDR, NUAK1, PIM1, PPARA, PRKCA, PRKCB, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 2.90094
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, IDO1 2.90094
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.90094
[BP] GO:0042391 None ADORA1, BCL2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 2.8962
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, F10, F3, MET, PRKCA, PRKCD, PRKCE, XDH 2.8962
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, PRKCA, PRKCB, TEK 2.89246
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, INSR, PRKCD, PTPN1, SRC 2.89246
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PRKCD, PTPN1, SRC, TEK, TNKS 2.89114
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, PRKCE, SRC 2.85038
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.85038
[BP] GO:0035408 None PRKCA, PRKCB 2.85038
[BP] GO:0009115 None AOX1, XDH 2.85038
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.85038
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.85038
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.85038
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD, PRKCE 2.85038
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 2.8383
[BP] GO:0010675 None ESRRB, INSR, PPARA, PRKCE, RORC, SRC 2.83249
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.81353
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PRKCD, PTPN1, SRC 2.81353
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 2.79362
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, EGFR, ESR1, ESR2, GRIK5, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.7929
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.79238
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, EGFR, ESR1, GPR35, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 2.76851
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, SLC1A1, SMAD3, TRPV1 2.76851
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.76085
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.76085
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.74031
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.74031
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PPARA, PRKCG, SMAD3 2.68039
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 2.67727
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TNKS 2.67727
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTPN1, SMAD3, SRC, XDH 2.67558
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.66859
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, SRC, TRPV1, TYR 2.66263
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 2.63456
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, PRKCE, SRC 2.61879
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2 2.61879
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, HMGCR, KDR, PRKCA, SRC, TEK 2.61683
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.61551
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.61551
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, INSR, MMP12, PRKCD, PRKCE, SMAD3, SRC, TRPV1 2.6022
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PRKCD 2.6022
[BP] GO:0071396 cellular response to lipid AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, PRKCE, RORC, SRC 2.5697
[BP] GO:0007610 None BCL2, EGFR, GRM1, GRM5, HMGCR, IDO1, INSR, PPARA, PRKCE, PRKCG, TRPV1 2.56923
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, PIM1, PPARA, TYR 2.55244
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1 2.53614
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, PRKCD, SRC, TEK, TRPV1 2.53614
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, XDH 2.53614
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, HMGCR, PPARA, PRKCD, SMAD3, TEK 2.52975
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, IDO1, KDR, MET, PRKCA, SMAD3 2.52975
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.52808
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 2.52808
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PRKCD, PTPN1, SRC, TEK 2.52428
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTPN1, XDH 2.52364
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.51812
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.51812
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.51812
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.50724
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, ESR1, GPR35, GRIK5, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 2.50478
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.48268
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, PRKCE, SRC 2.4576
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.45331
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.45331
[BP] GO:0099566 None GRM1, GRM5 2.45331
[BP] GO:0046110 None AOX1, XDH 2.45331
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45331
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, SRC, TEK 2.42406
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.41954
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, ESR1, GPR35, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 2.41905
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.40426
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.40426
[BP] GO:0051094 positive regulation of developmental process ALOX12, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, IDO1, INSR, KDR, PIM1, PRKCA, PRKCB, SMAD3, SRC, TEK 2.3932
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, ESR1, GPR35, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 2.38957
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.38762
[BP] GO:0090330 regulation of platelet aggregation ALOX12, PRKCA, PRKCD 2.38762
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, GRM5, IGF1R, INSR, KDR, MET, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 2.38762
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HCAR2, MMP12, PRKCE, SRC, TRPV1 2.38506
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PRKCD, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1 2.36926
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.36701
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.35299
[BP] GO:0045785 positive regulation of cell adhesion ALOX12, ALOX15, CDK6, KDR, PRKCA, PRKCE, SMAD3, SRC, TEK 2.34923
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, ESR1, GPR35, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 2.34274
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 2.34274
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.33647
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.32896
[BP] GO:0010605 negative regulation of macromolecule metabolic process AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PPARA, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 2.32766
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, PRKCE, SRC 2.32732
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, TNKS, TNKS2 2.3163
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, IDO1, MMP2, MMP9, NUAK1, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TRPV1 2.31227
[BP] GO:0055074 calcium ion homeostasis BCL2, ESR1, GPR35, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 2.30956
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSPA1A, IDO1, XDH 2.30696
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, GRM5, IGF1R, INSR, MMP2, PRKCD, SRC, TRPV1 2.29582
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, PRKCE, SMAD3, SRC, TNKS 2.28815
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.2854
[BP] GO:0045936 None DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 2.28005
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, ESR1, GPR35, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 2.27556
[BP] GO:0010563 None DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 2.27556
[BP] GO:0045934 None AURKB, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, MMP12, NR3C1, PPARA, PRKCA, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1 2.275
[BP] GO:0090087 None ACHE, ADORA1, CA2, EGFR, HCAR2, HMGCR, MMP12, PRKCA, PRKCD, PRKCE, PTPN1, SMAD3, SRC 2.26992
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.25972
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.25662
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.25659
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.25659
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.25659
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.25659
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.25033
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.24873
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.23744
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.23744
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, SRC, TRPV1, TYR 2.2331
[BP] GO:0070213 None TNKS, TNKS2 2.21534
[BP] GO:0006145 None AOX1, XDH 2.21534
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21534
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.21532
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 2.20832
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, PRKCB, PRKCD, RORC, SMAD3 2.20783
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, PIM1, PPARA, TYR 2.19588
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, SRC 2.19384
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.18007
[BP] GO:0043412 macromolecule modification ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.18007
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.17897
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.17897
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.17667
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.16862
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.16862
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PRKCD, PTPN1, SRC 2.16458
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSPA1A, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3, TRPV1 2.1559
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PRKCD, PRKCE, SRC 2.1559
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, GRIK5, HSPA1A, INSR, KDR, MET, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 2.1559
[BP] GO:0007162 negative regulation of cell adhesion ALOX12, CYP1B1, DUSP3, IDO1, PPARA, PRKCD, SRC 2.15174
[BP] GO:0071363 cellular response to growth factor stimulus EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.15174
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.1418
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.1418
[BP] GO:0044057 None ADORA1, ADORA3, EGFR, GPR35, GRM1, HCAR2, PRKCA, SLC1A1, SMAD3, TRPV1 2.1385
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, PIM1, PPARA, TYR 2.1345
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.134
[BP] GO:1901342 regulation of vasculature development ALOX12, CYP1B1, F3, KDR, PRKCA, PRKCB, TEK, XDH 2.13142
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, EGFR, GRIK5, HCAR2, HMGCR, MMP12, PRKCA, PRKCE, SRC, TRPV1 2.13142
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.12437
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, INSR, PPARA, PRKCE, RORC, SRC 2.12182
[BP] GO:0050679 None EGFR, F3, KDR, MMP12, PRKCA, TEK 2.10916
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, INSR, MMP2, MMP9, SRC 2.10074
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.1003
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, GRM5, IGF1R, INSR, MMP2, PRKCD, SRC, TRPV1 2.09486
[BP] GO:0051894 None KDR, SMAD3, TEK 2.08701
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.08701
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.07589
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PRKCD, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1 2.07589
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MMP12, PRKCE, SRC 2.06248
[BP] GO:0007154 None ADORA1, AXL, BCL2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1, TEK, TRPV1 2.04333
[BP] GO:0032870 cellular response to hormone stimulus EGFR, ESR1, FLT3, INSR, NR3C1, PRKCD, PRKCE, SRC 2.04333
[BP] GO:0050927 None F3, KDR, SMAD3 2.04333
[BP] GO:0034110 regulation of homotypic cell-cell adhesion ALOX12, PRKCA, PRKCD 2.04333
[BP] GO:0043696 None CDK6, ESRRB 2.04333
[BP] GO:0043697 None CDK6, ESRRB 2.04333
[BP] GO:0010641 None F3, SRC 2.04333
[BP] GO:0007598 None F10, F3 2.04333
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.04333
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.04333
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, IDO1 2.03075
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.01097
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.00703
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.00374
[BP] GO:0050926 None F3, KDR, SMAD3 2.00374
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.00374
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.00374
[BP] GO:1903393 None KDR, SMAD3, TEK 2.00374
[BP] GO:0055065 metal ion homeostasis BCL2, EGFR, ESR1, GPR35, GRM1, GRM5, PRKCB, PRKCE, SMAD3, TRPV1 2.0036
[BP] GO:2000026 regulation of multicellular organismal development ALOX12, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, F3, HMGCR, IDO1, INSR, KDR, PIM1, PRKCA, PRKCB, SMAD3, SRC, TEK, XDH 2.0036
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, EGFR, HCAR2, HMGCR, PRKCA, PRKCE 2.00305
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 5.74418
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR 5.24812
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PRKCG, SLC1A1, SRC, TEK, TRPV1 4.77426
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, BACE1, CA4, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 3.48993
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, BACE1, CA2, CA4, CA9, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PRKCG, SLC1A1, SRC, TEK, TRPV1 3.45749
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, MMP2, MMP9, NR3C1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 3.39432
[CC] GO:0044432 endoplasmic reticulum part BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, F10, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 3.20536
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, TRPV1 3.17329
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.08502
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MET, PRKCG, PTPN1, SLC1A1, SRC, TEK, TRPV1, TYR 3.06084
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 2.80831
[CC] GO:0005783 None ADORA1, BCL2, CA4, CYP19A1, FLT3, GBA2, GRIK5, HMGCR, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTPN1, XDH 2.69684
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 2.67245
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 2.60758
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 2.60758
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 2.55231
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 2.53614
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, BACE1, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK, TRPV1 2.35132
[CC] GO:0044456 None ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, SRC, TRPV1 2.297
[CC] GO:0031233 None CA4, F10, F3 2.27472
[CC] GO:0043235 receptor complex EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.19384
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 2.04333
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 21.3687
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.9842
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, TNKS, TNKS2, TYR, XDH 13.5283
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 13.5283
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS 11.0779
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.93713
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, TNKS, TNKS2, TRPV1, TYR, XDH 9.56915
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, TNKS, TNKS2, TRPV1, TYR, XDH 9.32685
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.80425
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 8.1615
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 8.06243
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, TYR, XDH 8.05116
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.92853
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.81833
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PRKCE, RORC, SMAD3, TEK, TRPV1 7.36287
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 7.34556
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.17457
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC 7.0019
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 6.98219
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.77394
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1 6.66339
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.54592
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.03811
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.03811
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.72652
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, SRC 5.70696
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.62258
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.5669
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.53552
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, TRPV1 5.53171
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 5.53171
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.53167
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.52943
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, SRC 5.49675
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B2, HSD17B1, IDO1, SRC, XDH 5.05511
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.00446
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.81128
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.81128
[MF] GO:0019899 enzyme binding AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSPA1A, MET, NR3C1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS2 4.75606
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 4.57321
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 4.45721
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 4.45721
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TRPV1, XDH 4.34139
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.30445
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.20952
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 4.11268
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 4.10188
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TRPV1, XDH 3.87254
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.80538
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1, XDH 3.58833
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1, XDH 3.58649
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NR3C1 3.55578
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1 3.46936
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1 3.32955
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1 3.29519
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, IDO1 3.27819
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.21504
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, IDO1 3.21504
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.17626
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.17626
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, EGFR, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.14687
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.1152
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.0541
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 3.04118
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.99713
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PRKCD 2.94141
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.94141
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.87084
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.85038
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85038
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.85038
[MF] GO:0003845 None HSD11B1, HSD11B2 2.85038
[MF] GO:0008389 None CYP2A13, CYP2A6 2.85038
[MF] GO:0035403 None PRKCA, PRKCB 2.85038
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.51812
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.47977
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, PRKCB, PRKCD, PTPN1, SMAD3, SRC 2.47009
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.45331
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.45331
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.45331
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.45331
[MF] GO:0099583 None GRM1, GRM5 2.45331
[MF] GO:0004699 None PRKCD, PRKCE 2.45331
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.3932
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1 2.36701
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, GRM5, NR3C1, PRKCB, PRKCD, PTPN1, SMAD3, SRC 2.35838
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.32896
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.32896
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1 2.2554
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1 2.22148
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TRPV1 2.21534
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21534
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.21534
[MF] GO:0004971 None GRIA2, GRIA4 2.21534
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.21534
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 2.20283
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.19588
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.16337
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.13827
[MF] GO:0001540 amyloid-beta binding ACHE, BACE1, GRIA2, INSR 2.1003
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.04333
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04333
[MF] GO:0043559 insulin binding IGF1R, INSR 2.04333
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.03579
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PTPN1 2.00703


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.1184
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, PRKCG, GRIA2, GRM5, PRKCB, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 9.5376
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.5669
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.5376
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, F3 7.6153
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 7.6153
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, KDR, PRKCA, MMP9, MET, ESR1, EGFR, IGF1R 7.337
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4001
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADORA1, TRPV1, NR3C1, GRM1, GRIA4 7.0378
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, CDK6, PRKCB, PRKCE, BCL2, PIM1, CYP1B1, PRKCA, MMP9, MET, EGFR, CDC25B 6.745
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, MMP9, EGFR, IGF1R, CDK6, BCL2, MET 6.4079
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PRKCB, SRC, PRKCE, PRKCD, PRKCA, ALOX12, TRPV1 6.6162
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 6.3057
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PRKCB, INSR, BCL2, PRKCA, TEK, EGFR, IGF1R 6.4828
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 5.8938
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.3057
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, SMAD3, PRKCB, SRC, BCL2, PRKCA, MMP9 5.5315
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PRKCB, SRC, KDR, BCL2, PRKCA, MET, EGFR, IGF1R 5.5315
Gap junction_Homo sapiens_hsa04540 PRKCG, GRM5, PRKCB, SRC, PRKCA, GRM1, EGFR 5.8327
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.9948
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1, GRIA4 5.5078
Long-term depression_Homo sapiens_hsa04730 PRKCG, GRIA2, PRKCB, PRKCA, GRM1, IGF1R 5.5439
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PRKCB, PRKCA, EGFR, IGF1R 5.4174
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PRKCB, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 5.216
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1 5.396
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA 5.1339
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, PRKCA, GRM1, EGFR 4.6463
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 4.6951
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.721
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, INSR, KDR, BCL2, PRKCA, TEK, MET, EGFR, IGF1R 3.9666
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PRKCB, INSR, PRKCE, PRKCD, PPARA 4.2921
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, ALOX5, ALOX15, PRKCA, ALOX12 4.2479
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PRKCB, INSR, PRKCA 5.216
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PRKCB, PRKCA, EGFR 4.5415
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PRKCB, SRC, KDR, PRKCA 4.3696
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 3.2113
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 4.2155
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PRKCB, BCL2, PRKCA 3.2325
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PRKCB, SRC, PRKCA, EGFR 3.6959
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.1878
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, GRM5, PRKCB, PRKCA, GRM1, EGFR 3.1976
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.1565
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.5429
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.5772
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.1962
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.2574
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PRKCB, SRC, PRKCA, ESR1 3.153
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 3.1274
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PRKCB, MMP2, PRKCA, MMP9 3.153
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.0208
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.9678
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.8523
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PRKCB, SRC, PRKCA, EGFR 2.6631
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, PPARA, GRIA4 2.2715
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.522
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, PRKCB, PRKCA, EGFR 2.5126
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.8318
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.0208
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.6617
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.967
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.7027
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 3.045
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.5815
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.5984
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.045
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1586
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, PRKCE, ADORA1 1.8202
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2289
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.238
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2495
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7357
Alzheimer's disease_Homo sapiens_hsa05010 BACE1 0.2603
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2854
Apoptosis_Homo sapiens_hsa04210 BCL2 0.31
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3212
Axon guidance_Homo sapiens_hsa04360 MET 0.3357
Platelet activation_Homo sapiens_hsa04611 SRC 0.3435
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3434
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.267
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5161
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3751
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6306
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5369
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.3749
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PRKCB, PRKCA 1.3788
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6059
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3914
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, HMGCR, IGF1R 1.4618
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.0155
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.3352
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3987
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.7916
Influenza A_Homo sapiens_hsa05164 PRKCB, PRKCA, HSPA1A 1.1395
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 0.7109
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.242
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.4618
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7036
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.5095
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4171
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7513
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7688
Chemokine signaling pathway_Homo sapiens_hsa04062 PRKCB, SRC, PRKCD 1.0809
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PRKCB, PRKCA 1.6832
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 1.8309
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 0.8286
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PRKCB, PRKCA 1.7022
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4358
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.7916
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2 1.7493
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4511
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4496
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4346
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4333
Peroxisome_Homo sapiens_hsa04146 XDH 0.4511
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9674
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0208
B cell receptor signaling pathway_Homo sapiens_hsa04662 PRKCB 0.4893
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0866
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4726
Leishmaniasis_Homo sapiens_hsa05140 PRKCB 0.4893
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9952
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 2.0994
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4991
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0207
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.504
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.1314
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PRKCB, PRKCA 2.1993
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA, IDO1 4.0812
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5016
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.0325
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5123
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.2729
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.0325
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0479
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5161
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0741
Shigellosis_Homo sapiens_hsa05131 SRC 0.515
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1117
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.1555
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1057
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5662
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.1647
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5662
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5817
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.5862
Malaria_Homo sapiens_hsa05144 MET 0.5986
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.2685
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.242
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6035
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3275
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PRKCB 0.6192
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.304
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6059
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, PRKCE, PRKCD 2.46
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3961
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4242
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.5075
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7091
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7513
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7908
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.573
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0208
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7685
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7991
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7752
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.758
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6749
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7908
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7357
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.656
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9755
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8608
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9404
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0275
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.216
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3352


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)