| GO Term |
GO Name |
Enriched Genes |
Log10 Adjusted P-value |
|
[BP] GO:0065008 |
regulation of biological quality
|
ABCB1, ABCG2, ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAOA, MET, MIF, MTNR1B, POLA1, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TRPV1, XDH |
15.3322 |
|
[BP] GO:0042221 |
response to chemical
|
ABCB1, ABCG2, ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MMP2, MMP9, MPO, POLB, PPARA, PTGES, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP1, TRPV1, TYR |
15.3322 |
|
[BP] GO:0010647 |
positive regulation of cell communication
|
ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
13.7213 |
|
[BP] GO:0023056 |
positive regulation of signaling
|
ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
13.7211 |
|
[BP] GO:1901700 |
response to oxygen-containing compound
|
ADRB2, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, MPO, POLB, PPARA, PTGES, PTGS2, RORC, SRC, TEK, TRPV1, TYR |
13.2917 |
|
[BP] GO:0006629 |
lipid metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, MIF, PPARA, PTGES, PTGS2, TBXAS1, TRPV1 |
13.2884 |
|
[BP] GO:0010033 |
response to organic substance
|
ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, MPO, POLB, PPARA, PTGES, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR |
13.2883 |
|
[BP] GO:0009967 |
positive regulation of signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
11.9047 |
|
[BP] GO:1902533 |
positive regulation of intracellular signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, PTGS2, PTPN1, SRC, TEK, XDH |
11.6969 |
|
[BP] GO:0042127 |
regulation of cell proliferation
|
ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, IDO1, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, PTGS2, SMAD3, SRC, TEK, TERT, XDH |
11.6969 |
|
[BP] GO:0044281 |
small molecule metabolic process
|
ABCG2, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR2B, HTR2C, IDO1, MIF, MPO, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR, XDH |
11.0356 |
|
[BP] GO:0033559 |
unsaturated fatty acid metabolic process
|
ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS2, TBXAS1 |
10.9493 |
|
[BP] GO:0010646 |
regulation of cell communication
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1B, NUAK1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
10.8698 |
|
[BP] GO:0008152 |
metabolic process
|
ABCG2, ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
10.7878 |
|
[BP] GO:0023051 |
regulation of signaling
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1B, NUAK1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
10.7053 |
|
[BP] GO:0048584 |
positive regulation of response to stimulus
|
ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
10.7053 |
|
[BP] GO:0048522 |
positive regulation of cellular process
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
10.7053 |
|
[BP] GO:0006690 |
icosanoid metabolic process
|
ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS2, TBXAS1 |
10.7053 |
|
[BP] GO:0043067 |
regulation of programmed cell death
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH |
10.5895 |
|
[BP] GO:0032879 |
regulation of localization
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB2, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1B, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 |
10.586 |
|
[BP] GO:0010941 |
regulation of cell death
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH |
10.3927 |
|
[BP] GO:0050896 |
response to stimulus
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, MPO, NUAK1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP1, TOP2A, TRPV1, TYR |
10.0553 |
|
[BP] GO:0032502 |
developmental process
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, HTR2A, HTR2B, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, MPO, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR |
9.93826 |
|
[BP] GO:0033993 |
response to lipid
|
ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, MPO, PTGES, PTGS2, RORC, SRC, TYR |
9.93826 |
|
[BP] GO:0032844 |
regulation of homeostatic process
|
ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, CNR1, EGFR, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PTGS2, SRC, TNKS, TNKS2, TRPV1 |
9.90553 |
|
[BP] GO:1902531 |
regulation of intracellular signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH |
9.82927 |
|
[BP] GO:0042493 |
response to drug
|
ABCB1, ABCG2, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSD11B2, HTR2A, HTR2B, HTR2C, KDR, POLB, PTGS2, SRC, TOP1, TRPV1 |
9.78049 |
|
[BP] GO:0048518 |
positive regulation of biological process
|
ABCB1, ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
9.64019 |
|
[BP] GO:0019369 |
arachidonic acid metabolic process
|
ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS2, TBXAS1 |
9.63822 |
|
[BP] GO:0032501 |
multicellular organismal process
|
ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CACNA1C, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HMGCR, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TOP1, TRPV1, TYR |
9.46619 |
|
[BP] GO:0042981 |
regulation of apoptotic process
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MIF, MMP9, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH |
9.38463 |
|
[BP] GO:0043069 |
negative regulation of programmed cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
9.13849 |
|
[BP] GO:0042592 |
homeostatic process
|
ABCG2, ADORA1, ADRB1, ADRB2, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, POLA1, POLB, SMAD3, SRC, TERT, TRPV1 |
9.13849 |
|
[BP] GO:0060548 |
negative regulation of cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, MPO, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
9.08667 |
|
[BP] GO:0008284 |
positive regulation of cell proliferation
|
AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT |
8.98994 |
|
[BP] GO:0040012 |
regulation of locomotion
|
ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CHRM1, CHRM4, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
8.93317 |
|
[BP] GO:0055114 |
oxidation-reduction process
|
AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MAOA, MPO, NQO2, PTGS2, TBXAS1, TYR, XDH |
8.88762 |
|
[BP] GO:0009719 |
response to endogenous stimulus
|
ADRB2, AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, KIT, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TRPV1 |
8.79578 |
|
[BP] GO:1901568 |
fatty acid derivative metabolic process
|
ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS2, TBXAS1 |
8.79578 |
|
[BP] GO:0044237 |
cellular metabolic process
|
ABCG2, ACHE, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, MPO, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH |
8.69542 |
|
[BP] GO:0009628 |
response to abiotic stimulus
|
ADORA1, ADRB1, ADRB2, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HMGCR, HSD11B2, HSPA1A, HTR2A, HTR2B, KIT, MMP2, MPO, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, TYR |
8.61433 |
|
[BP] GO:0048583 |
regulation of response to stimulus
|
ABCB1, ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
8.59237 |
|
[BP] GO:0008202 |
steroid metabolic process
|
AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
8.49414 |
|
[BP] GO:0010562 |
positive regulation of phosphorus metabolic process
|
ADORA1, ADRB1, ADRB2, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, MTNR1A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
8.48337 |
|
[BP] GO:0045937 |
positive regulation of phosphate metabolic process
|
ADORA1, ADRB1, ADRB2, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, MTNR1A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
8.48337 |
|
[BP] GO:0019748 |
secondary metabolic process
|
AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR |
8.44699 |
|
[BP] GO:0010035 |
response to inorganic substance
|
AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGES, PTGS2, SRC, TERT |
8.42881 |
|
[BP] GO:0014070 |
response to organic cyclic compound
|
ALPL, APEX1, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGES, PTGS2, RORC, SRC, TEK, TRPV1, TYR |
8.40118 |
|
[BP] GO:0051239 |
regulation of multicellular organismal process
|
ADORA1, ADORA3, ADRB1, ADRB2, APP, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH |
8.34048 |
|
[BP] GO:0044255 |
cellular lipid metabolic process
|
ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET, MIF, PPARA, PTGES, PTGS2, TBXAS1 |
8.27938 |
|
[BP] GO:0051270 |
regulation of cellular component movement
|
ADORA1, ADORA3, APEX1, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
8.20457 |
|
[BP] GO:2000145 |
regulation of cell motility
|
ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
8.15596 |
|
[BP] GO:0043066 |
negative regulation of apoptotic process
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MIF, MMP9, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT |
7.84624 |
|
[BP] GO:0051049 |
regulation of transport
|
ABCB1, ACHE, ADORA1, ADRB2, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CNR1, CYP19A1, EGFR, ERBB2, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, MIF, MMP12, MMP9, MTNR1B, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT, TRPV1 |
7.8058 |
|
[BP] GO:0010817 |
regulation of hormone levels
|
ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR2C, MTNR1B |
7.79182 |
|
[BP] GO:0043410 |
positive regulation of MAPK cascade
|
ADORA1, ADRB2, ALOX15, APP, EGFR, ERBB2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, PTPN1, SRC, TEK, XDH |
7.76875 |
|
[BP] GO:0048523 |
negative regulation of cellular process
|
ACHE, ADORA1, ADORA3, ADRB2, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, MPO, PIM1, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
7.72643 |
|
[BP] GO:0071704 |
organic substance metabolic process
|
ABCG2, ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
7.60033 |
|
[BP] GO:0009725 |
response to hormone
|
AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, KIT, PPARA, PTGS2, SRC, TEK, TRPV1 |
7.59411 |
|
[BP] GO:1903727 |
positive regulation of phospholipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC, TEK |
7.59188 |
|
[BP] GO:0006631 |
fatty acid metabolic process
|
ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGES, PTGS2, TBXAS1 |
7.5403 |
|
[BP] GO:0051173 |
positive regulation of nitrogen compound metabolic process
|
ADORA1, ADRB1, ADRB2, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
7.48691 |
|
[BP] GO:0048519 |
negative regulation of biological process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, MPO, PIM1, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
7.42815 |
|
[BP] GO:0032787 |
None
|
ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, MIF, PPARA, PTGES, PTGS2, TBXAS1 |
7.36345 |
|
[BP] GO:0009966 |
regulation of signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH |
7.35594 |
|
[BP] GO:0019220 |
regulation of phosphate metabolic process
|
ADORA1, ADRB1, ADRB2, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, MTNR1A, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.33016 |
|
[BP] GO:0019216 |
regulation of lipid metabolic process
|
ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, RORC, SRC, TEK |
7.32531 |
|
[BP] GO:0001676 |
long-chain fatty acid metabolic process
|
ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS2, TBXAS1 |
7.25451 |
|
[BP] GO:0051174 |
regulation of phosphorus metabolic process
|
ADORA1, ADRB1, ADRB2, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, MTNR1A, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.25451 |
|
[BP] GO:0006796 |
phosphate-containing compound metabolic process
|
ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH |
7.25362 |
|
[BP] GO:0080134 |
regulation of response to stress
|
ABCB1, ADORA1, APP, CDK6, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IDO1, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH |
7.20992 |
|
[BP] GO:0030334 |
regulation of cell migration
|
ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
7.20992 |
|
[BP] GO:0048513 |
animal organ development
|
ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, POLB, PPARA, PTPRS, SMAD3, SRC, TEK, TYR |
7.20409 |
|
[BP] GO:0044238 |
primary metabolic process
|
ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
7.13645 |
|
[BP] GO:0070887 |
cellular response to chemical stimulus
|
ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TERT, TRPV1 |
7.07946 |
|
[BP] GO:0031325 |
positive regulation of cellular metabolic process
|
ADORA1, ADRB1, ADRB2, ALOX15, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
7.04313 |
|
[BP] GO:0070372 |
regulation of ERK1 and ERK2 cascade
|
ALOX15, APP, DUSP3, EGFR, ERBB2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PTPN1, SRC, TEK |
7.04313 |
|
[BP] GO:0043408 |
regulation of MAPK cascade
|
ADORA1, ADRB2, ALOX15, APP, DUSP3, EGFR, ERBB2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, PTPN1, SRC, TEK, XDH |
7.02997 |
|
[BP] GO:0032845 |
None
|
ADORA1, BCL2, HMGCR, HTR2A, HTR2B, HTR2C, MIF, SRC, TNKS, TNKS2, TRPV1 |
6.96308 |
|
[BP] GO:0006793 |
phosphorus metabolic process
|
ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH |
6.78243 |
|
[BP] GO:0051240 |
positive regulation of multicellular organismal process
|
ADRB1, ADRB2, APP, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, IDO1, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1 |
6.77768 |
|
[BP] GO:0042327 |
positive regulation of phosphorylation
|
ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, TEK, XDH |
6.7334 |
|
[BP] GO:0046777 |
protein autophosphorylation
|
AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK |
6.68193 |
|
[BP] GO:0003018 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2, SRC, TEK |
6.65054 |
|
[BP] GO:0009893 |
positive regulation of metabolic process
|
ADORA1, ADRB1, ADRB2, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
6.55107 |
|
[BP] GO:0045834 |
positive regulation of lipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC, TEK |
6.47404 |
|
[BP] GO:0048585 |
negative regulation of response to stimulus
|
ADORA1, ADRB2, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ERBB2, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH |
6.47404 |
|
[BP] GO:0001934 |
positive regulation of protein phosphorylation
|
ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, TEK, XDH |
6.40607 |
|
[BP] GO:0007165 |
signal transduction
|
ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, APP, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, POLB, PPARA, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 |
6.40607 |
|
[BP] GO:0071310 |
cellular response to organic substance
|
ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, PTGS2, RORC, SMAD3, SRC, TRPV1 |
6.37254 |
|
[BP] GO:0030335 |
positive regulation of cell migration
|
APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
6.22935 |
|
[BP] GO:0051716 |
cellular response to stimulus
|
ADRB2, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 |
6.20844 |
|
[BP] GO:0008283 |
cell proliferation
|
ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, ERBB2, ESR1, FLT3, KIT, MET, MIF, PIM1, POLA1, SRC, TEK, TYR |
6.18378 |
|
[BP] GO:0050790 |
regulation of catalytic activity
|
ADORA1, ADORA3, ADRB1, ADRB2, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
6.13483 |
|
[BP] GO:0015701 |
bicarbonate transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
6.09537 |
|
[BP] GO:2000147 |
positive regulation of cell motility
|
APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
6.03474 |
|
[BP] GO:0007187 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, HTR6, MTNR1A, MTNR1B |
5.9667 |
|
[BP] GO:0007568 |
aging
|
APEX1, AURKB, BCL2, CNR1, CYP1A1, HMGCR, HTR2A, MIF, MPO, POLB, PTGS2, TERT |
5.96075 |
|
[BP] GO:1903725 |
regulation of phospholipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC, TEK |
5.96075 |
|
[BP] GO:0043405 |
regulation of MAP kinase activity
|
ADORA1, DUSP3, EGFR, ERBB2, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PTPN1, SRC |
5.95971 |
|
[BP] GO:0048511 |
rhythmic process
|
AXL, BCL2, CSNK2A1, EGFR, ESR1, KIT, MTNR1A, MTNR1B, PPARA, RORC, SRC, TOP1, TOP2A |
5.9528 |
|
[BP] GO:0010648 |
negative regulation of cell communication
|
ACHE, ADORA1, ADRB2, BCL2, CNR2, DUSP3, EGFR, ERBB2, ESR1, ESR2, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH |
5.94438 |
|
[BP] GO:0023057 |
negative regulation of signaling
|
ACHE, ADORA1, ADRB2, BCL2, CNR2, DUSP3, EGFR, ERBB2, ESR1, ESR2, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH |
5.91979 |
|
[BP] GO:0018108 |
peptidyl-tyrosine phosphorylation
|
AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK |
5.91598 |
|
[BP] GO:0051272 |
positive regulation of cellular component movement
|
APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
5.89989 |
|
[BP] GO:0006950 |
response to stress
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, HSD11B2, HSPA1A, HTR2C, IDO1, KIT, MIF, MMP2, MMP9, MPO, NUAK1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 |
5.89989 |
|
[BP] GO:0018212 |
peptidyl-tyrosine modification
|
AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK |
5.853 |
|
[BP] GO:0006468 |
protein phosphorylation
|
APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 |
5.84589 |
|
[BP] GO:0009987 |
cellular process
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH |
5.81565 |
|
[BP] GO:0042325 |
regulation of phosphorylation
|
ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ERBB2, ESRRB, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, PPARA, PTGS2, PTPN1, SRC, TEK, XDH |
5.81029 |
|
[BP] GO:0065009 |
regulation of molecular function
|
ABCB1, ADORA1, ADORA3, ADRB1, ADRB2, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TRPV1, XDH |
5.80127 |
|
[BP] GO:0048878 |
chemical homeostasis
|
ABCG2, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, SMAD3, TRPV1 |
5.79467 |
|
[BP] GO:0040017 |
positive regulation of locomotion
|
APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT |
5.71061 |
|
[BP] GO:0051897 |
positive regulation of protein kinase B signaling
|
AXL, EGFR, ERBB2, F10, F3, INSR, KIT, MET, SRC, TEK |
5.69488 |
|
[BP] GO:0070374 |
positive regulation of ERK1 and ERK2 cascade
|
ALOX15, APP, EGFR, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, SRC, TEK |
5.69314 |
|
[BP] GO:0051050 |
positive regulation of transport
|
ABCB1, ACHE, ADORA1, ADRB2, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, ERBB2, HCAR2, HTR2B, INSR, MIF, MMP12, PTGS2, SMAD3, SRC, TERT, TRPV1 |
5.65127 |
|
[BP] GO:0006082 |
organic acid metabolic process
|
ABCG2, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, MIF, MPO, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR |
5.63807 |
|
[BP] GO:0003013 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2, SRC, TEK |
5.52293 |
|
[BP] GO:0050793 |
regulation of developmental process
|
ADRB1, ADRB2, APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, HMGCR, HTR2A, HTR2C, IDO1, INSR, KDR, KIT, MIF, NUAK1, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TRPV1, XDH |
5.51793 |
|
[BP] GO:0090087 |
None
|
ACHE, ADORA1, APP, CA2, CACNA1C, CHRM1, CNR1, EGFR, ERBB2, HCAR2, HMGCR, HTR2B, HTR2C, MIF, MMP12, MTNR1B, PTGS2, PTPN1, SMAD3, SRC |
5.50419 |
|
[BP] GO:1901564 |
organonitrogen compound metabolic process
|
ABCG2, ACHE, ADRB2, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH |
5.49096 |
|
[BP] GO:2000021 |
regulation of ion homeostasis
|
ADORA1, BCL2, CA2, CA7, CACNA1C, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 |
5.47206 |
|
[BP] GO:0010038 |
response to metal ion
|
ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGES, PTGS2, TERT |
5.42582 |
|
[BP] GO:0051896 |
regulation of protein kinase B signaling
|
AXL, EGFR, ERBB2, F10, F3, INSR, KIT, MET, SRC, TEK, XDH |
5.41356 |
|
[BP] GO:0010604 |
positive regulation of macromolecule metabolic process
|
ADORA1, ADRB2, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH |
5.40007 |
|
[BP] GO:0001932 |
regulation of protein phosphorylation
|
ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, TEK, XDH |
5.38377 |
|
[BP] GO:0048856 |
anatomical structure development
|
ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, KIT, MMP9, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR |
5.38377 |
|
[BP] GO:0044057 |
None
|
ADORA1, ADORA3, ADRB1, ADRB2, CACNA1C, CHRM1, CHRM2, EGFR, GPR35, HCAR2, HTR2A, HTR2C, KIT, PTGS2, SMAD3, TRPV1 |
5.38306 |
|
[BP] GO:0097746 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2 |
5.37362 |
|
[BP] GO:0035296 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2 |
5.37362 |
|
[BP] GO:0009891 |
positive regulation of biosynthetic process
|
ADRB1, ADRB2, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
5.32435 |
|
[BP] GO:0010243 |
response to organonitrogen compound
|
ADRB2, AKR1B1, APEX1, APP, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TRPV1, TYR |
5.26659 |
|
[BP] GO:0006730 |
one-carbon metabolic process
|
CA1, CA12, CA2, CA4, CA7, CA9 |
5.23029 |
|
[BP] GO:0051247 |
positive regulation of protein metabolic process
|
ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.19666 |
|
[BP] GO:0050880 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2 |
5.15302 |
|
[BP] GO:0019752 |
carboxylic acid metabolic process
|
ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, MIF, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR |
5.15124 |
|
[BP] GO:0043436 |
oxoacid metabolic process
|
ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, MIF, MPO, PIM1, PPARA, PTGES, PTGS2, TBXAS1, TYR |
5.1341 |
|
[BP] GO:0035150 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2 |
5.13224 |
|
[BP] GO:0032270 |
positive regulation of cellular protein metabolic process
|
ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.11653 |
|
[BP] GO:0044093 |
positive regulation of molecular function
|
ABCB1, ADORA1, ADRB1, ADRB2, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
5.11317 |
|
[BP] GO:0032101 |
regulation of response to external stimulus
|
ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MIF, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK |
5.09388 |
|
[BP] GO:1901652 |
response to peptide
|
ADRB2, AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 |
5.02641 |
|
[BP] GO:0070482 |
response to oxygen levels
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, TERT |
4.99352 |
|
[BP] GO:0042445 |
hormone metabolic process
|
ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.97744 |
|
[BP] GO:0019373 |
epoxygenase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 |
4.94753 |
|
[BP] GO:0031328 |
positive regulation of cellular biosynthetic process
|
ADRB1, ADRB2, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
4.94619 |
|
[BP] GO:0071073 |
None
|
FABP3, HTR2A, HTR2B, HTR2C |
4.87009 |
|
[BP] GO:0050804 |
modulation of chemical synaptic transmission
|
ACHE, ADORA1, ADRB2, APP, CA2, CA7, CNR1, CNR2, EGFR, HTR2A, KIT, PTGS2 |
4.85073 |
|
[BP] GO:0099177 |
regulation of trans-synaptic signaling
|
ACHE, ADORA1, ADRB2, APP, CA2, CA7, CNR1, CNR2, EGFR, HTR2A, KIT, PTGS2 |
4.85073 |
|
[BP] GO:0071900 |
regulation of protein serine/threonine kinase activity
|
ADORA1, ADRB2, DUSP3, EGFR, ERBB2, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PTPN1, SRC |
4.81698 |
|
[BP] GO:1901698 |
response to nitrogen compound
|
ADRB2, AKR1B1, APEX1, APP, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TRPV1, TYR |
4.80472 |
|
[BP] GO:0048869 |
cellular developmental process
|
ACHE, ADRB1, ADRB2, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HTR2B, KDR, KIT, MET, MIF, MMP2, MMP9, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A |
4.77485 |
|
[BP] GO:0051338 |
regulation of transferase activity
|
ADORA1, ADRB2, APP, AURKB, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PTPN1, SRC, TEK, TNKS |
4.6919 |
|
[BP] GO:0031401 |
positive regulation of protein modification process
|
ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PTGS2, PTPN1, SRC, TEK, XDH |
4.67317 |
|
[BP] GO:0001666 |
response to hypoxia
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT |
4.61389 |
|
[BP] GO:0043085 |
positive regulation of catalytic activity
|
ADORA1, ADRB1, ADRB2, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MIF, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH |
4.61389 |
|
[BP] GO:0048661 |
positive regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT |
4.61389 |
|
[BP] GO:0043549 |
regulation of kinase activity
|
ADORA1, ADRB2, APP, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PTPN1, SRC, TEK |
4.60664 |
|
[BP] GO:0065007 |
biological regulation
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH |
4.60664 |
|
[BP] GO:0043406 |
positive regulation of MAP kinase activity
|
ADORA1, EGFR, ERBB2, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PTPN1, SRC |
4.53775 |
|
[BP] GO:0019371 |
None
|
CBR1, PTGES, PTGS2, TBXAS1 |
4.50051 |
|
[BP] GO:0036293 |
response to decreased oxygen levels
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT |
4.49303 |
|
[BP] GO:0031399 |
regulation of protein modification process
|
ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH |
4.48268 |
|
[BP] GO:0007610 |
None
|
APP, BCL2, CNR1, EGFR, HMGCR, HTR2A, HTR2B, HTR2C, IDO1, INSR, KIT, MTNR1A, PPARA, PTGS2, TRPV1 |
4.46575 |
|
[BP] GO:0016310 |
phosphorylation
|
APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 |
4.43999 |
|
[BP] GO:0031347 |
regulation of defense response
|
ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK |
4.42818 |
|
[BP] GO:0045859 |
regulation of protein kinase activity
|
ADORA1, ADRB2, APP, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PTPN1, SRC |
4.41416 |
|
[BP] GO:0009636 |
response to toxic substance
|
AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, POLB, SRC |
4.40137 |
|
[BP] GO:0044092 |
negative regulation of molecular function
|
ADORA3, ADRB2, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS |
4.35927 |
|
[BP] GO:0032496 |
response to lipopolysaccharide
|
ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGES, PTGS2, SRC |
4.35869 |
|
[BP] GO:0002683 |
negative regulation of immune system process
|
ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ERBB2, IDO1, MIF, MMP12, PTPRS |
4.35869 |
|
[BP] GO:0006979 |
response to oxidative stress
|
AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, MPO, PTGS2, SRC |
4.31301 |
|
[BP] GO:0007200 |
None
|
CHRM1, CHRM2, CHRM4, ESR1, HTR2A, HTR2B, HTR2C |
4.25411 |
|
[BP] GO:0071902 |
positive regulation of protein serine/threonine kinase activity
|
ADORA1, ADRB2, EGFR, ERBB2, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PTPN1, SRC |
4.21481 |
|
[BP] GO:0071407 |
cellular response to organic cyclic compound
|
ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 |
4.21481 |
|
[BP] GO:0009605 |
response to external stimulus
|
ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HMGCR, HSD11B2, HTR2A, IDO1, KIT, MMP12, MPO, PTGES, PTGS2, SMAD3, SRC, TRPV1, TYR |
4.19737 |
|
[BP] GO:0032847 |
regulation of cellular pH reduction
|
BCL2, CA2, CA7 |
4.18735 |
|
[BP] GO:0070201 |
None
|
ACHE, APP, BCL2, CACNA1C, CHRM1, CNR1, EGFR, ERBB2, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PTGS2, PTPN1, SMAD3, SRC |
4.1708 |
|
[BP] GO:0009611 |
response to wounding
|
ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, ERBB2, PPARA, SMAD3 |
4.15652 |
|
[BP] GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway
|
AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TEK |
4.15142 |
|
[BP] GO:0001659 |
None
|
ADORA1, ADRB1, ADRB2, HTR2A, TRPV1 |
4.1503 |
|
[BP] GO:0019222 |
regulation of metabolic process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH |
4.1414 |
|
[BP] GO:0007346 |
regulation of mitotic cell cycle
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A |
4.13381 |
|
[BP] GO:0002237 |
response to molecule of bacterial origin
|
ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MPO, PTGES, PTGS2, SRC |
4.10909 |
|
[BP] GO:0002682 |
regulation of immune system process
|
ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ERBB2, ESR1, ESRRA, HCAR2, HSPA1A, IDO1, KIT, MIF, MMP12, MMP2, PTPN1, PTPRS, SMAD3, SRC |
4.09838 |
|
[BP] GO:0009991 |
response to extracellular stimulus
|
ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, MPO, PTGS2, SRC, TRPV1, TYR |
4.09358 |
|
[BP] GO:0032228 |
regulation of synaptic transmission, GABAergic
|
ADORA1, CA2, CA7, CNR1, CNR2 |
4.08981 |
|
[BP] GO:1901701 |
cellular response to oxygen-containing compound
|
ADRB2, AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PTGS2, RORC, SRC, TRPV1 |
4.06715 |
|
[BP] GO:0050801 |
ion homeostasis
|
ABCG2, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
4.06621 |
|
[BP] GO:0032880 |
regulation of protein localization
|
ACHE, APP, BCL2, CACNA1C, CHRM1, CNR1, CSNK2A1, EGFR, ERBB2, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PTGS2, PTPN1, SMAD3, SRC, TERT |
4.06157 |
|
[BP] GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
4.03788 |
|
[BP] GO:0010863 |
positive regulation of phospholipase C activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
4.03651 |
|
[BP] GO:0042446 |
hormone biosynthetic process
|
AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.99624 |
|
[BP] GO:0071495 |
cellular response to endogenous stimulus
|
ADRB2, AKR1B1, APEX1, APP, EGFR, ERBB2, ESR1, FLT3, IGF1R, INSR, KIT, MMP2, PTGS2, SMAD3, SRC, TRPV1 |
3.95933 |
|
[BP] GO:0051347 |
positive regulation of transferase activity
|
ADORA1, ADRB2, AURKB, CDC25B, EGFR, ERBB2, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PTPN1, SRC, TEK, TNKS |
3.94454 |
|
[BP] GO:0022414 |
reproductive process
|
AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, INSR, KIT, MMP2, MMP9, MTNR1A, PTGS2, SRC, TOP2A |
3.9101 |
|
[BP] GO:0002791 |
None
|
ACHE, ADORA1, CACNA1C, CNR1, EGFR, HCAR2, HMGCR, HTR2B, HTR2C, MIF, MMP12, MTNR1B, SRC |
3.90472 |
|
[BP] GO:0017144 |
drug metabolic process
|
ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A, IDO1, MAOA, MPO |
3.90472 |
|
[BP] GO:0043269 |
regulation of ion transport
|
ABCB1, ADORA1, ADRB2, APP, BCL2, CA2, CA7, CACNA1C, CHRM1, CNR1, GPR35, HTR2A, MIF, MMP9, PTGS2 |
3.89685 |
|
[BP] GO:0007154 |
None
|
ADORA1, ADRB1, ADRB2, AXL, BCL2, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, ESR2, HTR2A, HTR2C, HTR6, MTNR1B, PTGS2, TEK, TRPV1 |
3.89124 |
|
[BP] GO:0071071 |
None
|
FABP3, HTR2A, HTR2B, HTR2C |
3.86954 |
|
[BP] GO:0051223 |
None
|
ACHE, APP, CACNA1C, CHRM1, CNR1, EGFR, ERBB2, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PTGS2, PTPN1, SMAD3, SRC |
3.86954 |
|
[BP] GO:0051094 |
positive regulation of developmental process
|
ADRB2, APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HMGCR, HTR2A, HTR2C, IDO1, INSR, KDR, KIT, PIM1, PTGS2, SMAD3, SRC, TEK, TERT |
3.86692 |
|
[BP] GO:1900274 |
regulation of phospholipase C activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
3.86361 |
|
[BP] GO:0006940 |
None
|
ADORA1, ADRB2, CHRM1, CHRM2, KIT, PTGS2 |
3.85841 |
|
[BP] GO:0007197 |
None
|
CHRM1, CHRM2, CHRM4 |
3.85841 |
|
[BP] GO:0010513 |
None
|
HTR2A, HTR2B, HTR2C |
3.85841 |
|
[BP] GO:0018193 |
peptidyl-amino acid modification
|
AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS, TOP1, TOP2A |
3.84455 |
|
[BP] GO:0050727 |
regulation of inflammatory response
|
ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK |
3.83521 |
|
[BP] GO:0051130 |
positive regulation of cellular component organization
|
ADRB2, ALOX15, APP, AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 |
3.82024 |
|
[BP] GO:0046456 |
icosanoid biosynthetic process
|
ALOX15, ALOX5, MIF, PTGES, PTGS2 |
3.81887 |
|
[BP] GO:0008217 |
None
|
ADORA1, ADRB1, ADRB2, CNR1, HSD11B2, PPARA, PTGS2, SMAD3 |
3.81496 |
|
[BP] GO:0009266 |
None
|
ADORA1, ADRB1, ADRB2, HSPA1A, HTR2A, HTR2B, PTGS2, TRPV1 |
3.79635 |
|
[BP] GO:0044236 |
multicellular organism metabolic process
|
ADRB1, ADRB2, MMP1, MMP12, MMP2, MMP9, TRPV1 |
3.76306 |
|
[BP] GO:0045935 |
positive regulation of nucleobase-containing compound metabolic process
|
ADRB1, ADRB2, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A |
3.75878 |
|
[BP] GO:0046883 |
regulation of hormone secretion
|
ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HCAR2, HMGCR, HTR2A, HTR2C, MTNR1B |
3.75878 |
|
[BP] GO:0009968 |
negative regulation of signal transduction
|
ADRB2, BCL2, DUSP3, EGFR, ERBB2, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH |
3.75878 |
|
[BP] GO:0033674 |
positive regulation of kinase activity
|
ADORA1, ADRB2, CDC25B, EGFR, ERBB2, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PTPN1, SRC, TEK |
3.75674 |
|
[BP] GO:0007186 |
G-protein coupled receptor signaling pathway
|
ADORA1, ADORA3, ADRB1, ADRB2, APP, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, INSR, MTNR1A, MTNR1B, SRC |
3.75606 |
|
[BP] GO:0043393 |
regulation of protein binding
|
ADRB2, APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT |
3.75606 |
|
[BP] GO:0042180 |
None
|
AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, IDO1 |
3.73351 |
|
[BP] GO:0034754 |
cellular hormone metabolic process
|
AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 |
3.72688 |
|
[BP] GO:0034614 |
cellular response to reactive oxygen species
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC |
3.72688 |
|
[BP] GO:0097756 |
None
|
ADORA1, HMGCR, HTR2A, HTR2B, PTGS2 |
3.72688 |
|
[BP] GO:0008610 |
lipid biosynthetic process
|
ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PTGES, PTGS2 |
3.72315 |
|
[BP] GO:0031667 |
response to nutrient levels
|
ALPL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, MPO, PTGS2, SRC, TRPV1, TYR |
3.67714 |
|
[BP] GO:0098771 |
inorganic ion homeostasis
|
ABCG2, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
3.66277 |
|
[BP] GO:0051701 |
interaction with host
|
AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC |
3.65531 |
|
[BP] GO:0050890 |
None
|
ADORA1, APP, CHRM1, CNR1, EGFR, HMGCR, HTR2A, INSR, KIT, PTGS2 |
3.65134 |
|
[BP] GO:0009894 |
regulation of catabolic process
|
ADORA1, ADRB2, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PTPN1, SMAD3 |
3.63481 |
|
[BP] GO:1904407 |
positive regulation of nitric oxide metabolic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.62972 |
|
[BP] GO:0045429 |
positive regulation of nitric oxide biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.62972 |
|
[BP] GO:0051046 |
None
|
ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, MIF, MMP12, MTNR1B, SRC, TRPV1 |
3.6293 |
|
[BP] GO:0080135 |
regulation of cellular response to stress
|
APP, CDK6, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MIF, NUAK1, PTGS2, PTPN1, PTPRS, TERT, XDH |
3.61582 |
|
[BP] GO:0007207 |
None
|
CHRM1, CHRM2, CHRM4 |
3.61012 |
|
[BP] GO:1901615 |
organic hydroxy compound metabolic process
|
AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HMGCR, MAOA, TYR |
3.59437 |
|
[BP] GO:0051098 |
regulation of binding
|
ADRB2, APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS |
3.59437 |
|
[BP] GO:0001503 |
ossification
|
ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK |
3.59373 |
|
[BP] GO:0006805 |
xenobiotic metabolic process
|
CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, RORC |
3.59373 |
|
[BP] GO:0040008 |
regulation of growth
|
ADRB1, ADRB2, APP, BCL2, CSNK2A1, EGFR, ERBB2, ESR2, HSPA1A, INSR, MPO, PIM1, PTPRS, SMAD3, TNKS2 |
3.5921 |
|
[BP] GO:0045776 |
None
|
ADORA1, ADRB1, ADRB2, CNR1, PPARA |
3.58965 |
|
[BP] GO:0032103 |
positive regulation of response to external stimulus
|
CNR1, EGFR, F3, FABP4, IDO1, KDR, MET, MIF, PTGS2, SMAD3 |
3.57214 |
|
[BP] GO:0080090 |
regulation of primary metabolic process
|
ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
3.56131 |
|
[BP] GO:0035690 |
cellular response to drug
|
AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, PTGS2, SRC, TRPV1 |
3.53662 |
|
[BP] GO:0048871 |
multicellular organismal homeostasis
|
ADORA1, ADRB1, ADRB2, AKR1B1, HTR2A, MET, TRPV1 |
3.50537 |
|
[BP] GO:0050999 |
None
|
CNR1, CNR2, EGFR, HTR2B, TERT |
3.49732 |
|
[BP] GO:2000377 |
regulation of reactive oxygen species metabolic process
|
BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH |
3.46856 |
|
[BP] GO:0032846 |
positive regulation of homeostatic process
|
AURKB, CA2, CA7, CNR1, EGFR, HCAR2, PTGS2, TNKS, TNKS2 |
3.45658 |
|
[BP] GO:0007167 |
enzyme linked receptor protein signaling pathway
|
AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK |
3.44291 |
|
[BP] GO:0050806 |
positive regulation of synaptic transmission
|
ADORA1, ADRB2, APP, CA2, CA7, EGFR, PTGS2 |
3.44133 |
|
[BP] GO:0009698 |
phenylpropanoid metabolic process
|
CYP1A1, CYP2A13, CYP2A6 |
3.4025 |
|
[BP] GO:0009804 |
coumarin metabolic process
|
CYP1A1, CYP2A13, CYP2A6 |
3.4025 |
|
[BP] GO:0010511 |
None
|
HTR2A, HTR2B, HTR2C |
3.4025 |
|
[BP] GO:0045860 |
positive regulation of protein kinase activity
|
ADORA1, ADRB2, CDC25B, EGFR, ERBB2, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PTPN1, SRC |
3.39875 |
|
[BP] GO:0050730 |
None
|
ADORA1, APP, EGFR, FLT3, HTR2A, KIT, MIF, PTPN1, SRC |
3.395 |
|
[BP] GO:1903530 |
regulation of secretion by cell
|
ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, MIF, MMP12, MTNR1B, SRC |
3.395 |
|
[BP] GO:0000302 |
response to reactive oxygen species
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC |
3.395 |
|
[BP] GO:1904951 |
positive regulation of establishment of protein localization
|
ACHE, APP, BCL2, CHRM1, EGFR, ERBB2, HCAR2, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC |
3.395 |
|
[BP] GO:0030522 |
intracellular receptor signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC |
3.38085 |
|
[BP] GO:1902532 |
negative regulation of intracellular signal transduction
|
BCL2, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH |
3.38085 |
|
[BP] GO:0038083 |
peptidyl-tyrosine autophosphorylation
|
EGFR, IGF1R, INSR, KDR, SRC |
3.3802 |
|
[BP] GO:0051726 |
regulation of cell cycle
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PTGS2, SMAD3, SRC, TERT, TNKS, TOP2A |
3.35889 |
|
[BP] GO:0006694 |
steroid biosynthetic process
|
AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.34912 |
|
[BP] GO:0009056 |
catabolic process
|
ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, HSPA1A, IDO1, MAOA, MMP1, MMP12, MMP2, MMP9, MPO, SRC, XDH |
3.34223 |
|
[BP] GO:0003008 |
None
|
ADORA1, ADRB1, ADRB2, AKR1B1, APP, BCL2, CHRM1, CNR1, CNR2, CYP1B1, EGFR, HMGCR, HSD11B2, HTR2A, HTR2B, INSR, KIT, PTGS2, SRC, TEK, TRPV1, TYR |
3.32232 |
|
[BP] GO:0045787 |
positive regulation of cell cycle
|
APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC, TERT |
3.32144 |
|
[BP] GO:0043065 |
positive regulation of apoptotic process
|
BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
3.32144 |
|
[BP] GO:0048660 |
regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT |
3.3105 |
|
[BP] GO:0010518 |
positive regulation of phospholipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
3.30119 |
|
[BP] GO:0007166 |
cell surface receptor signaling pathway
|
ADORA1, ADORA3, ADRB2, APP, AXL, BCL2, CA1, CHRM4, CSNK2A1, EGFR, ERBB2, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 |
3.29964 |
|
[BP] GO:0043068 |
positive regulation of programmed cell death
|
BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
3.27824 |
|
[BP] GO:0043401 |
steroid hormone mediated signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC |
3.27256 |
|
[BP] GO:0010638 |
positive regulation of organelle organization
|
ADRB2, ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 |
3.26606 |
|
[BP] GO:0008285 |
negative regulation of cell proliferation
|
ADORA1, ADORA3, APP, BCL2, CDK6, CYP1B1, ERBB2, FABP3, HSPA1A, IDO1, PTGES, PTGS2, SMAD3, TERT, XDH |
3.26488 |
|
[BP] GO:0008210 |
estrogen metabolic process
|
CYP19A1, CYP1B1, HSD17B1, HSD17B2 |
3.2539 |
|
[BP] GO:0007210 |
None
|
HTR2A, HTR2B, HTR2C, HTR6 |
3.2539 |
|
[BP] GO:0098664 |
None
|
HTR2A, HTR2B, HTR2C, HTR6 |
3.2539 |
|
[BP] GO:1903409 |
reactive oxygen species biosynthetic process
|
CYP1A1, CYP1A2, CYP1B1, MPO |
3.2539 |
|
[BP] GO:0009892 |
negative regulation of metabolic process
|
ADORA1, APEX1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH |
3.2448 |
|
[BP] GO:0031649 |
None
|
ADRB1, ADRB2, TRPV1 |
3.24252 |
|
[BP] GO:1903428 |
positive regulation of reactive oxygen species biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.19247 |
|
[BP] GO:0055080 |
cation homeostasis
|
ABCG2, APP, BCL2, CA2, CA7, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
3.17985 |
|
[BP] GO:0043207 |
response to external biotic stimulus
|
ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGES, PTGS2, SMAD3, SRC |
3.17985 |
|
[BP] GO:2000379 |
positive regulation of reactive oxygen species metabolic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH |
3.1641 |
|
[BP] GO:0006693 |
None
|
CES2, MIF, PTGES, PTGS2 |
3.12153 |
|
[BP] GO:0006692 |
None
|
CES2, MIF, PTGES, PTGS2 |
3.12153 |
|
[BP] GO:0007584 |
response to nutrient
|
ALPL, CNR1, CYP1A1, EGFR, HMGCR, PTGS2, TRPV1, TYR |
3.1117 |
|
[BP] GO:0071417 |
cellular response to organonitrogen compound
|
ADRB2, AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC, TRPV1 |
3.09933 |
|
[BP] GO:0034599 |
cellular response to oxidative stress
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC |
3.09866 |
|
[BP] GO:2000026 |
regulation of multicellular organismal development
|
ADRB2, APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, HMGCR, IDO1, INSR, KDR, KIT, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, XDH |
3.09866 |
|
[BP] GO:0032768 |
None
|
CNR1, CNR2, EGFR, HTR2B, TERT |
3.08484 |
|
[BP] GO:0002024 |
None
|
ADRB1, ADRB2, TRPV1 |
3.08382 |
|
[BP] GO:0043271 |
negative regulation of ion transport
|
ADORA1, BCL2, CNR1, GPR35, HTR2A, MMP9, PTGS2 |
3.07227 |
|
[BP] GO:0042391 |
None
|
ADORA1, ADRB2, APP, BCL2, CACNA1C, CNR1, CNR2, GPR35, KDR, SRC, TRPV1 |
3.05797 |
|
[BP] GO:0046686 |
response to cadmium ion
|
CYP1A2, EGFR, KIT, MMP9, TERT |
3.05319 |
|
[BP] GO:0051222 |
positive regulation of protein transport
|
ACHE, APP, CHRM1, EGFR, ERBB2, HCAR2, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC |
3.03437 |
|
[BP] GO:0050678 |
None
|
CDK6, EGFR, ERBB2, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH |
3.02428 |
|
[BP] GO:0045931 |
positive regulation of mitotic cell cycle
|
APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT |
3.02099 |
|
[BP] GO:0045428 |
regulation of nitric oxide biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.01988 |
|
[BP] GO:0030003 |
cellular cation homeostasis
|
ABCG2, APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
3.01443 |
|
[BP] GO:0009895 |
negative regulation of catabolic process
|
ADORA1, BCL2, CNR1, EGFR, HCAR2, HTR2B, MET, PPARA, SMAD3 |
3.01247 |
|
[BP] GO:0050873 |
None
|
ADRB1, ADRB2, FABP4, PTGS2 |
3.0109 |
|
[BP] GO:0031323 |
regulation of cellular metabolic process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
2.98862 |
|
[BP] GO:0009607 |
response to biotic stimulus
|
ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGES, PTGS2, SMAD3, SRC |
2.98251 |
|
[BP] GO:0010942 |
positive regulation of cell death
|
BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
2.96479 |
|
[BP] GO:0034502 |
protein localization to chromosome
|
AURKB, ESR1, TERT, TNKS, TNKS2 |
2.96363 |
|
[BP] GO:0010517 |
regulation of phospholipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
2.96363 |
|
[BP] GO:0051966 |
regulation of synaptic transmission, glutamatergic
|
ADORA1, CNR1, EGFR, HTR2A, PTGS2 |
2.96363 |
|
[BP] GO:0071248 |
cellular response to metal ion
|
ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.96363 |
|
[BP] GO:0006636 |
unsaturated fatty acid biosynthetic process
|
ALOX15, MIF, PTGES, PTGS2 |
2.96363 |
|
[BP] GO:0032268 |
regulation of cellular protein metabolic process
|
ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
2.96363 |
|
[BP] GO:0050789 |
regulation of biological process
|
ABCB1, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH |
2.96363 |
|
[BP] GO:2001225 |
regulation of chloride transport
|
ABCB1, CA2, CA7 |
2.96363 |
|
[BP] GO:0097267 |
omega-hydroxylase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
2.96363 |
|
[BP] GO:0006873 |
cellular ion homeostasis
|
ABCG2, APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
2.92613 |
|
[BP] GO:0051828 |
entry into other organism involved in symbiotic interaction
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.92613 |
|
[BP] GO:0030260 |
entry into host cell
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.92613 |
|
[BP] GO:0051806 |
entry into cell of other organism involved in symbiotic interaction
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.92613 |
|
[BP] GO:0044409 |
entry into host
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.92613 |
|
[BP] GO:0072507 |
divalent inorganic cation homeostasis
|
APP, BCL2, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
2.91715 |
|
[BP] GO:0015711 |
organic anion transport
|
ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 |
2.91715 |
|
[BP] GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity
|
FLT3, KIT, SRC, TEK |
2.91564 |
|
[BP] GO:0042743 |
hydrogen peroxide metabolic process
|
CYP1A1, CYP1A2, EGFR, MPO |
2.91564 |
|
[BP] GO:0050794 |
regulation of cellular process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
2.91199 |
|
[BP] GO:0072593 |
reactive oxygen species metabolic process
|
BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MPO |
2.90819 |
|
[BP] GO:0001952 |
regulation of cell-matrix adhesion
|
BCL2, CDK6, KDR, SMAD3, SRC, TEK |
2.88628 |
|
[BP] GO:0051704 |
multi-organism process
|
APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR2A, IDO1, INSR, KDR, MET, MMP1, MMP12, MPO, POLA1, SMAD3, SRC, TOP1 |
2.88628 |
|
[BP] GO:2001234 |
negative regulation of apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC, TERT |
2.88628 |
|
[BP] GO:0051171 |
regulation of nitrogen compound metabolic process
|
ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TRPV1, XDH |
2.883 |
|
[BP] GO:0060193 |
positive regulation of lipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
2.88005 |
|
[BP] GO:0050708 |
None
|
ACHE, CACNA1C, CNR1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, SRC |
2.87094 |
|
[BP] GO:0014065 |
phosphatidylinositol 3-kinase signaling
|
ERBB2, HTR2A, HTR2B, IGF1R |
2.86703 |
|
[BP] GO:0043434 |
None
|
APEX1, FABP3, HSD11B2, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 |
2.86179 |
|
[BP] GO:0031960 |
response to corticosteroid
|
ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC |
2.85933 |
|
[BP] GO:0008150 |
biological_process
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH |
2.85534 |
|
[BP] GO:0032102 |
negative regulation of response to external stimulus
|
ADORA1, CNR2, CYP19A1, HMGCR, MIF, PPARA, PTPRS, SMAD3, TEK |
2.85363 |
|
[BP] GO:0002320 |
lymphoid progenitor cell differentiation
|
BCL2, FLT3, KIT |
2.85363 |
|
[BP] GO:0007188 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, CNR1 |
2.84861 |
|
[BP] GO:1901699 |
cellular response to nitrogen compound
|
ADRB2, AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC, TRPV1 |
2.84498 |
|
[BP] GO:0060255 |
regulation of macromolecule metabolic process
|
ACHE, ADORA1, ADORA3, ADRB2, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, XDH |
2.83032 |
|
[BP] GO:0050805 |
negative regulation of synaptic transmission
|
ACHE, ADORA1, CNR2, HTR2A, PTGS2 |
2.82917 |
|
[BP] GO:0046889 |
None
|
FABP3, HTR2A, HTR2B, HTR2C, PTGS2 |
2.82917 |
|
[BP] GO:0060402 |
None
|
CACNA1C, HTR2A, HTR2B, HTR2C, TRPV1 |
2.82917 |
|
[BP] GO:2001242 |
regulation of intrinsic apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
2.81919 |
|
[BP] GO:0006464 |
cellular protein modification process
|
ADRB2, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A |
2.81695 |
|
[BP] GO:0036211 |
protein modification process
|
ADRB2, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A |
2.81695 |
|
[BP] GO:0003006 |
developmental process involved in reproduction
|
ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, PTGS2, SRC |
2.81695 |
|
[BP] GO:0007208 |
None
|
HTR2A, HTR2C |
2.81647 |
|
[BP] GO:0009115 |
None
|
AOX1, XDH |
2.81647 |
|
[BP] GO:0006286 |
base-excision repair, base-free sugar-phosphate removal
|
APEX1, POLB |
2.81647 |
|
[BP] GO:1903522 |
None
|
ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, EGFR, HTR2A, PTGS2 |
2.80504 |
|
[BP] GO:0048545 |
response to steroid hormone
|
ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC |
2.80504 |
|
[BP] GO:0042542 |
response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC |
2.80504 |
|
[BP] GO:0019725 |
cellular homeostasis
|
ABCG2, APEX1, APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, POLA1, SMAD3, TRPV1 |
2.80258 |
|
[BP] GO:0006954 |
inflammatory response
|
ADORA1, ADORA3, ALOX15, AXL, CNR2, KIT, MIF, POLB, PTGES, PTGS2, TRPV1 |
2.80258 |
|
[BP] GO:0035556 |
intracellular signal transduction
|
ADRB1, ADRB2, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, EGFR, ERBB2, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MET, MIF, NUAK1, POLB, PTPN1, SRC, TEK |
2.79423 |
|
[BP] GO:0090218 |
positive regulation of lipid kinase activity
|
FLT3, KIT, SRC, TEK |
2.79182 |
|
[BP] GO:0010907 |
None
|
ESRRB, INSR, PPARA, SRC |
2.79182 |
|
[BP] GO:0006937 |
None
|
ADORA1, ADRB2, CACNA1C, CHRM1, CHRM2, KIT, PTGS2 |
2.78755 |
|
[BP] GO:0023052 |
None
|
ADORA1, ADRB1, ADRB2, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, ESR2, HTR2A, HTR2C, HTR6, MTNR1B, TEK |
2.77382 |
|
[BP] GO:0022900 |
electron transport chain
|
AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH |
2.77315 |
|
[BP] GO:0044283 |
None
|
AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, HMGCR, IDO1, MIF, MPO, PTGES, PTGS2 |
2.77315 |
|
[BP] GO:0045759 |
None
|
CNR1, CNR2, GPR35 |
2.76411 |
|
[BP] GO:0040014 |
regulation of multicellular organism growth
|
ADRB1, ADRB2, APP, BCL2, TNKS2 |
2.75974 |
|
[BP] GO:0045913 |
None
|
ESRRB, HTR2A, INSR, PPARA, SRC |
2.7304 |
|
[BP] GO:0044267 |
cellular protein metabolic process
|
ADRB2, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, POLB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A |
2.72768 |
|
[BP] GO:0090066 |
None
|
ADORA1, ADRB1, ADRB2, ALOX15, CHRM1, EGFR, HMGCR, HTR2A, HTR2B, PTGS2 |
2.70368 |
|
[BP] GO:0090257 |
None
|
ADORA1, ADRB2, CACNA1C, CHRM1, CHRM2, KIT, PTGS2, SMAD3 |
2.70126 |
|
[BP] GO:0048534 |
hematopoietic or lymphoid organ development
|
BCL2, FLT3, KDR, KIT, POLB, TEK, TYR |
2.70126 |
|
[BP] GO:0009755 |
hormone-mediated signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC |
2.70126 |
|
[BP] GO:0051093 |
None
|
ADRB1, ADRB2, APP, BCL2, CDK6, EGFR, ERBB2, ESRRB, MIF, PPARA, PTPRS, SMAD3, TEK, TERT, TRPV1, XDH |
2.69168 |
|
[BP] GO:0050728 |
negative regulation of inflammatory response
|
ADORA1, CNR2, CYP19A1, PPARA, SMAD3, TEK |
2.67412 |
|
[BP] GO:0006703 |
estrogen biosynthetic process
|
CYP19A1, HSD17B1, HSD17B2 |
2.66691 |
|
[BP] GO:0001516 |
None
|
MIF, PTGES, PTGS2 |
2.66691 |
|
[BP] GO:0046457 |
None
|
MIF, PTGES, PTGS2 |
2.66691 |
|
[BP] GO:0007267 |
None
|
ADORA1, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, CNR1, ESR2, HTR2A, HTR2C, HTR6, MTNR1B, TEK |
2.65768 |
|
[BP] GO:0045926 |
negative regulation of growth
|
ADRB1, ADRB2, BCL2, ESR2, HSPA1A, MPO, PTPRS, SMAD3 |
2.65594 |
|
[BP] GO:0010564 |
regulation of cell cycle process
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, MIF, TERT, TNKS |
2.65594 |
|
[BP] GO:0031348 |
negative regulation of defense response
|
ADORA1, CNR2, CYP19A1, MMP12, PPARA, SMAD3, TEK |
2.64421 |
|
[BP] GO:0071241 |
cellular response to inorganic substance
|
ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.62906 |
|
[BP] GO:0007611 |
None
|
APP, CNR1, EGFR, HMGCR, HTR2A, INSR, KIT, PTGS2 |
2.62129 |
|
[BP] GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation
|
ADORA1, FLT3, HTR2A, KIT, MIF, PTPN1, SRC |
2.61673 |
|
[BP] GO:0055065 |
metal ion homeostasis
|
ABCG2, APP, BCL2, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
2.61528 |
|
[BP] GO:0019538 |
protein metabolic process
|
ACHE, ADRB2, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A |
2.61366 |
|
[BP] GO:0006874 |
cellular calcium ion homeostasis
|
APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
2.60546 |
|
[BP] GO:0051047 |
None
|
ACHE, ADORA1, CYP19A1, EGFR, HCAR2, HTR2B, MIF, MMP12, SRC, TRPV1 |
2.59684 |
|
[BP] GO:0050679 |
None
|
EGFR, ERBB2, F3, HTR2B, KDR, MMP12, TEK |
2.59051 |
|
[BP] GO:1904018 |
positive regulation of vasculature development
|
CYP1B1, F3, KDR, KIT, PTGS2, TEK, TERT |
2.59051 |
|
[BP] GO:0060065 |
uterus development
|
CYP19A1, ESR1, SRC |
2.57932 |
|
[BP] GO:1990845 |
None
|
ADRB1, ADRB2, TRPV1 |
2.57932 |
|
[BP] GO:0016477 |
cell migration
|
AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, SRC, TEK |
2.54505 |
|
[BP] GO:0060401 |
None
|
CACNA1C, HTR2A, HTR2B, HTR2C, TRPV1 |
2.52651 |
|
[BP] GO:0043412 |
macromolecule modification
|
ADRB2, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TOP2A |
2.52481 |
|
[BP] GO:0071363 |
cellular response to growth factor stimulus
|
APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC, TRPV1 |
2.50591 |
|
[BP] GO:0055074 |
calcium ion homeostasis
|
APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
2.5028 |
|
[BP] GO:0042060 |
None
|
ALOX15, EGFR, ERBB2, PPARA, SMAD3 |
2.5028 |
|
[BP] GO:0006720 |
isoprenoid metabolic process
|
AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR |
2.49765 |
|
[BP] GO:0010634 |
positive regulation of epithelial cell migration
|
KDR, MET, MMP9, PTGS2, SRC, TEK |
2.49765 |
|
[BP] GO:0030154 |
cell differentiation
|
ADRB1, ADRB2, ALPL, AXL, BCL2, CBR1, CDK6, CYP1A1, ERBB2, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HTR2B, KDR, KIT, MMP2, MMP9, PTGS2, RORC, SMAD3, TOP2A |
2.49765 |
|
[BP] GO:0055082 |
cellular chemical homeostasis
|
ABCG2, APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
2.49609 |
|
[BP] GO:0050965 |
None
|
ADORA1, HTR2A, TRPV1 |
2.49609 |
|
[BP] GO:0050961 |
None
|
ADORA1, HTR2A, TRPV1 |
2.49609 |
|
[BP] GO:0070198 |
None
|
TERT, TNKS, TNKS2 |
2.49609 |
|
[BP] GO:0051128 |
regulation of cellular component organization
|
ADRB2, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
2.49609 |
|
[BP] GO:0072503 |
cellular divalent inorganic cation homeostasis
|
APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
2.46541 |
|
[BP] GO:0001101 |
response to acid chemical
|
AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, SRC |
2.45295 |
|
[BP] GO:1901570 |
None
|
ALOX15, ALOX5, MIF, PTGES, PTGS2 |
2.43463 |
|
[BP] GO:0006875 |
cellular metal ion homeostasis
|
ABCG2, APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
2.43413 |
|
[BP] GO:0001775 |
cell activation
|
ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, MPO, RORC, SMAD3, SRC, TRPV1 |
2.43257 |
|
[BP] GO:0010810 |
regulation of cell-substrate adhesion
|
ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK |
2.42128 |
|
[BP] GO:0007213 |
None
|
CHRM1, CHRM2, CHRM4 |
2.42128 |
|
[BP] GO:0030540 |
female genitalia development
|
AXL, CYP19A1, ESR1 |
2.42128 |
|
[BP] GO:0070920 |
None
|
EGFR, ESR1, TERT |
2.42128 |
|
[BP] GO:0045986 |
None
|
ADORA1, ADRB2, PTGS2 |
2.42128 |
|
[BP] GO:0019372 |
lipoxygenase pathway
|
ALOX15, ALOX5, PTGS2 |
2.42128 |
|
[BP] GO:1900182 |
positive regulation of protein localization to nucleus
|
APP, EGFR, PTGS2, SMAD3, SRC, TERT |
2.42128 |
|
[BP] GO:0046683 |
response to organophosphorus
|
APEX1, APP, PTGS2, TEK, TRPV1, TYR |
2.42128 |
|
[BP] GO:0098502 |
DNA dephosphorylation
|
APEX1, POLB |
2.41815 |
|
[BP] GO:0046110 |
None
|
AOX1, XDH |
2.41815 |
|
[BP] GO:0032849 |
positive regulation of cellular pH reduction
|
CA2, CA7 |
2.41815 |
|
[BP] GO:0002520 |
None
|
CACNA1C, SMAD3 |
2.41815 |
|
[BP] GO:0002025 |
None
|
ADRB1, ADRB2 |
2.41815 |
|
[BP] GO:0001505 |
regulation of neurotransmitter levels
|
ACHE, CYP1B1, EGFR, INSR, MAOA, PTGS2, SMAD3, TRPV1 |
2.41648 |
|
[BP] GO:0002793 |
None
|
ACHE, ADORA1, EGFR, HCAR2, HTR2B, MIF, MMP12, SRC |
2.41648 |
|
[BP] GO:0030155 |
regulation of cell adhesion
|
ALOX15, BCL2, CDK6, CYP1B1, DUSP3, ERBB2, IDO1, KDR, NUAK1, PPARA, SMAD3, SRC, TEK |
2.41648 |
|
[BP] GO:0043551 |
regulation of phosphatidylinositol 3-kinase activity
|
FLT3, KIT, SRC, TEK |
2.40678 |
|
[BP] GO:2000106 |
regulation of leukocyte apoptotic process
|
AURKB, AXL, HCAR2, IDO1, MIF |
2.40678 |
|
[BP] GO:0044070 |
regulation of anion transport
|
ABCB1, ADORA1, CA2, CA7, MIF |
2.40678 |
|
[BP] GO:0033273 |
response to vitamin
|
ALPL, CYP1A1, EGFR, PTGS2, TYR |
2.40678 |
|
[BP] GO:1903426 |
None
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
2.40678 |
|
[BP] GO:0033554 |
cellular response to stress
|
AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, POLA1, POLB, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1 |
2.39398 |
|
[BP] GO:1901342 |
regulation of vasculature development
|
CYP1B1, ERBB2, F3, KDR, KIT, PTGS2, TEK, TERT, XDH |
2.38853 |
|
[BP] GO:0001816 |
cytokine production
|
APP, FABP4, IDO1, KIT, PTGS2 |
2.38414 |
|
[BP] GO:0051336 |
regulation of hydrolase activity
|
ADRB1, APP, CSNK2A1, EGFR, ERBB2, ESR1, F3, HSPA1A, HTR2A, HTR2B, KIT, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, XDH |
2.38047 |
|
[BP] GO:1901989 |
None
|
APEX1, APP, CDC25B, CYP1A1, TERT |
2.36182 |
|
[BP] GO:1904355 |
positive regulation of telomere capping
|
AURKB, TNKS, TNKS2 |
2.35871 |
|
[BP] GO:0002521 |
leukocyte differentiation
|
AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC |
2.35768 |
|
[BP] GO:0031324 |
negative regulation of cellular metabolic process
|
APEX1, APP, AURKB, BCL2, CNR1, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TRPV1, XDH |
2.34074 |
|
[BP] GO:0060191 |
regulation of lipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
2.34061 |
|
[BP] GO:0051209 |
None
|
HTR2A, HTR2B, HTR2C, TRPV1 |
2.33934 |
|
[BP] GO:0001954 |
positive regulation of cell-matrix adhesion
|
CDK6, KDR, SMAD3, TEK |
2.33934 |
|
[BP] GO:0051283 |
None
|
HTR2A, HTR2B, HTR2C, TRPV1 |
2.33934 |
|
[BP] GO:0007623 |
circadian rhythm
|
EGFR, MTNR1A, MTNR1B, PPARA, RORC, TOP1 |
2.33837 |
|
[BP] GO:0051246 |
regulation of protein metabolic process
|
ADORA1, ADRB2, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
2.3294 |
|
[BP] GO:0090342 |
None
|
CDK6, MIF, NUAK1, TERT |
2.30406 |
|
[BP] GO:0016137 |
None
|
AKR1B1, AKR1B10, GBA2 |
2.29103 |
|
[BP] GO:0045821 |
None
|
ESRRB, HTR2A, INSR |
2.29103 |
|
[BP] GO:0051384 |
response to glucocorticoid
|
ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 |
2.29103 |
|
[BP] GO:0051241 |
negative regulation of multicellular organismal process
|
ADORA1, ADRB1, ADRB2, APP, AXL, BCL2, CDK6, EGFR, ERBB2, GPR35, IDO1, PTGS2, PTPRS, SMAD3, TEK, TERT, XDH |
2.28365 |
|
[BP] GO:0051341 |
None
|
CNR1, CNR2, EGFR, HTR2B, TERT |
2.27869 |
|
[BP] GO:2000107 |
negative regulation of leukocyte apoptotic process
|
AURKB, AXL, IDO1, MIF |
2.27277 |
|
[BP] GO:0048608 |
reproductive structure development
|
AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC |
2.26963 |
|
[BP] GO:0016042 |
lipid catabolic process
|
ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 |
2.26963 |
|
[BP] GO:0016048 |
None
|
ADORA1, HTR2A, TRPV1 |
2.22491 |
|
[BP] GO:0051900 |
regulation of mitochondrial depolarization
|
BCL2, KDR, SRC |
2.22491 |
|
[BP] GO:0051197 |
None
|
ESRRB, HTR2A, INSR |
2.22491 |
|
[BP] GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH |
2.21258 |
|
[BP] GO:1901653 |
cellular response to peptide
|
ADRB2, AKR1B1, APEX1, APP, IGF1R, INSR, SRC |
2.18903 |
|
[BP] GO:0014074 |
response to purine-containing compound
|
APEX1, APP, PTGS2, TEK, TRPV1, TYR |
2.18442 |
|
[BP] GO:0010557 |
positive regulation of macromolecule biosynthetic process
|
ADRB2, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A |
2.1804 |
|
[BP] GO:0070848 |
response to growth factor
|
APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC, TRPV1 |
2.17984 |
|
[BP] GO:0048870 |
cell motility
|
AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, SRC, TEK |
2.161 |
|
[BP] GO:0040011 |
locomotion
|
AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MET, MIF, MMP1, MMP12, MMP9, SRC, TEK |
2.161 |
|
[BP] GO:0072330 |
monocarboxylic acid biosynthetic process
|
ALOX15, CYP1A1, IDO1, MIF, PTGES, PTGS2 |
2.161 |
|
[BP] GO:0070213 |
None
|
TNKS, TNKS2 |
2.161 |
|
[BP] GO:0006145 |
None
|
AOX1, XDH |
2.161 |
|
[BP] GO:0038171 |
None
|
CNR1, CNR2 |
2.161 |
|
[BP] GO:0018894 |
dibenzo-p-dioxin metabolic process
|
CYP1A1, CYP1A2 |
2.161 |
|
[BP] GO:0002009 |
morphogenesis of an epithelium
|
BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC |
2.15722 |
|
[BP] GO:0051054 |
positive regulation of DNA metabolic process
|
AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 |
2.13858 |
|
[BP] GO:0016311 |
None
|
ALPL, APEX1, BCL2, CDC25B, DUSP3, POLB, PTPN1, PTPRS |
2.13858 |
|
[BP] GO:0006807 |
nitrogen compound metabolic process
|
ABCG2, ACHE, ADRB2, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TYR, XDH |
2.13784 |
|
[BP] GO:0051480 |
regulation of cytosolic calcium ion concentration
|
CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3, TRPV1 |
2.13042 |
|
[BP] GO:0009416 |
response to light stimulus
|
APP, AURKB, BCL2, EGFR, HMGCR, KIT, PTGS2, TYR |
2.13042 |
|
[BP] GO:0010906 |
None
|
ESRRB, INSR, PPARA, RORC, SRC |
2.12724 |
|
[BP] GO:0010676 |
None
|
ESRRB, INSR, PPARA, SRC |
2.12724 |
|
[BP] GO:0050994 |
None
|
ADORA1, CNR1, HCAR2, PPARA |
2.12724 |
|
[BP] GO:0043550 |
regulation of lipid kinase activity
|
FLT3, KIT, SRC, TEK |
2.12724 |
|
[BP] GO:0002695 |
negative regulation of leukocyte activation
|
AXL, CNR1, CNR2, DUSP3, ERBB2, IDO1 |
2.12507 |
|
[BP] GO:0032872 |
regulation of stress-activated MAPK cascade
|
APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH |
2.12242 |
|
[BP] GO:0045595 |
regulation of cell differentiation
|
APP, AXL, BCL2, CA2, CDK6, CNR1, EGFR, ERBB2, ESRRA, ESRRB, HTR2A, HTR2C, KDR, KIT, PPARA, PTGS2, PTPRS, RORC, SMAD3, TERT, TRPV1, XDH |
2.12176 |
|
[BP] GO:0071498 |
cellular response to fluid shear stress
|
CA2, PTGS2, SRC |
2.11779 |
|
[BP] GO:0032094 |
None
|
CYP1A1, HSD11B2, MPO |
2.11779 |
|
[BP] GO:0070302 |
regulation of stress-activated protein kinase signaling cascade
|
APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH |
2.11299 |
|
[BP] GO:0014066 |
regulation of phosphatidylinositol 3-kinase signaling
|
EGFR, FLT3, KDR, KIT, TEK |
2.11275 |
|
[BP] GO:0098900 |
None
|
CACNA1C, CNR1, CNR2, GPR35 |
2.10299 |
|
[BP] GO:0048146 |
positive regulation of fibroblast proliferation
|
CDK6, EGFR, ESR1, MIF |
2.10299 |
|
[BP] GO:0032210 |
regulation of telomere maintenance via telomerase
|
AURKB, SRC, TNKS, TNKS2 |
2.10299 |
|
[BP] GO:0045766 |
positive regulation of angiogenesis
|
CYP1B1, F3, KDR, PTGS2, TEK, TERT |
2.08675 |
|
[BP] GO:0006928 |
movement of cell or subcellular component
|
APP, AXL, CNR2, CYP1B1, EGFR, ERBB2, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PTGS2, SRC, TEK, TUBB3 |
2.08321 |
|
[BP] GO:0033138 |
positive regulation of peptidyl-serine phosphorylation
|
APP, BCL2, EGFR, MIF, PTGS2 |
2.07784 |
|
[BP] GO:1901184 |
None
|
ADORA1, APP, EGFR, ERBB2, MMP9 |
2.07784 |
|
[BP] GO:0009889 |
regulation of biosynthetic process
|
ADORA3, ADRB1, ADRB2, APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MMP12, MTNR1A, PIM1, POLA1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TRPV1 |
2.07784 |
|
[BP] GO:0051893 |
regulation of focal adhesion assembly
|
KDR, SMAD3, SRC, TEK |
2.07784 |
|
[BP] GO:0033555 |
multicellular organismal response to stress
|
ADRB1, BCL2, HTR2C, IDO1 |
2.07784 |
|
[BP] GO:0090109 |
regulation of cell-substrate junction assembly
|
KDR, SMAD3, SRC, TEK |
2.07784 |
|
[BP] GO:0006820 |
anion transport
|
ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 |
2.07438 |
|
[BP] GO:0090344 |
None
|
CDK6, MIF, TERT |
2.07222 |
|
[BP] GO:0022612 |
gland morphogenesis
|
BCL2, EGFR, POLB |
2.07222 |
|
[BP] GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation
|
MMP2, MMP9, TERT |
2.07222 |
|
[BP] GO:0051194 |
None
|
ESRRB, HTR2A, INSR |
2.07222 |
|
[BP] GO:0030520 |
intracellular estrogen receptor signaling pathway
|
ESR1, ESR2, SRC |
2.07222 |
|
[BP] GO:0050995 |
None
|
ADORA1, CNR1, HCAR2 |
2.07222 |
|
[BP] GO:0051345 |
None
|
ADRB1, APP, EGFR, ERBB2, ESR1, F3, HSPA1A, HTR2A, HTR2B, KIT, PTPN1, SMAD3, XDH |
2.06753 |
|
[BP] GO:0048609 |
multicellular organismal reproductive process
|
AKR1B1, APP, AXL, CNR1, CYP1A1, EGFR, ESR1, KIT, MTNR1A, PTGS2, SRC |
2.04812 |
|
[BP] GO:0099536 |
None
|
CHRM1, CHRM2, CHRM4, CNR1, HTR2A, HTR2C, HTR6, MTNR1B |
2.01952 |
|
[BP] GO:0099537 |
None
|
CHRM1, CHRM2, CHRM4, CNR1, HTR2A, HTR2C, HTR6, MTNR1B |
2.01952 |
|
[BP] GO:0095500 |
None
|
CHRM1, CHRM2, CHRM4 |
2.01952 |
|
[BP] GO:0009404 |
toxin metabolic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.01952 |
|
[BP] GO:1903831 |
None
|
CHRM1, CHRM2, CHRM4 |
2.01952 |
|
[BP] GO:0006367 |
transcription initiation from RNA polymerase II promoter
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC |
2.01547 |
|
[BP] GO:2001233 |
regulation of apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT |
2.00384 |
|
[BP] GO:0097553 |
None
|
HTR2A, HTR2B, HTR2C, TRPV1 |
2.00282 |
|
[BP] GO:1903391 |
regulation of adherens junction organization
|
KDR, SMAD3, SRC, TEK |
2.00282 |
|
[CC] GO:0044459 |
plasma membrane part
|
ABCB1, ABCG2, ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PTGS2, PTPRS, SRC, TEK, TRPV1 |
7.08511 |
|
[CC] GO:0031226 |
intrinsic component of plasma membrane
|
ADORA1, ADORA3, ADRB1, ADRB2, APP, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, F10, F3, FLT3, GPR35, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PTPRS, TEK, TRPV1 |
6.58257 |
|
[CC] GO:0005886 |
plasma membrane
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, EGFR, ERBB2, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TRPV1 |
6.37737 |
|
[CC] GO:0016020 |
membrane
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TRPV1, TYR |
5.81416 |
|
[CC] GO:0005887 |
integral component of plasma membrane
|
ADORA1, ADORA3, ADRB1, ADRB2, APP, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, GPR35, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PTPRS, TEK, TRPV1 |
5.23868 |
|
[CC] GO:0044425 |
membrane part
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TEK, TRPV1, TYR |
5.09864 |
|
[CC] GO:0098590 |
plasma membrane region
|
ABCB1, ABCG2, ADORA1, ADRB2, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, EGFR, ERBB2, HTR2A, INSR, MET, PTGS2, SRC, TEK, TRPV1 |
4.34872 |
|
[CC] GO:0044444 |
cytoplasmic part
|
ABCG2, ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CDK6, CES2, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, IDO1, INSR, KDR, KIT, MAOA, MIF, MMP2, MMP9, MPO, NQO2, PIM1, POLA1, PTGES, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TYR, XDH |
4.07845 |
|
[CC] GO:0044464 |
cell part
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH |
3.56131 |
|
[CC] GO:0031224 |
None
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ERBB2, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTPRS, TBXAS1, TEK, TRPV1, TYR |
3.39319 |
|
[CC] GO:0044432 |
endoplasmic reticulum part
|
APP, BCL2, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGES, PTGS2, PTPN1, TBXAS1 |
3.27256 |
|
[CC] GO:0005641 |
nuclear envelope lumen
|
ALOX5, APP, PTGES |
3.24252 |
|
[CC] GO:0009330 |
None
|
TOP1, TOP2A |
2.81647 |
|
[CC] GO:0045121 |
membrane raft
|
APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK |
2.72768 |
|
[CC] GO:0016021 |
None
|
ABCB1, ABCG2, ADORA1, ADORA3, ADRB1, ADRB2, ALPL, APP, AXL, CA12, CA14, CA9, CACNA1C, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAOA, MET, MTNR1A, MTNR1B, PTGES, PTPRS, TBXAS1, TEK, TRPV1, TYR |
2.72541 |
|
[CC] GO:0098857 |
membrane microdomain
|
APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK |
2.70707 |
|
[CC] GO:0005789 |
endoplasmic reticulum membrane
|
BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGES, PTGS2, TBXAS1 |
2.62732 |
|
[CC] GO:0043235 |
receptor complex
|
ABCG2, ADRB2, APP, EGFR, ERBB2, IGF1R, INSR, MTNR1A, SMAD3 |
2.45295 |
|
[CC] GO:0016323 |
basolateral plasma membrane
|
ADORA1, CA2, CA4, CA9, EGFR, ERBB2, TEK |
2.4413 |
|
[CC] GO:0098589 |
membrane region
|
APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK |
2.19172 |
|
[CC] GO:0031233 |
None
|
CA4, F10, F3 |
2.16297 |
|
[CC] GO:0043226 |
organelle
|
ABCB1, ABCG2, ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CA9, CACNA1C, CBR1, CDK6, CES2, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR2A, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MIF, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH |
2.15295 |
|
[CC] GO:0005783 |
None
|
ADORA1, APEX1, APP, BCL2, CA4, CES2, CYP19A1, FLT3, GBA2, HMGCR, HSPA1A, KDR, PTGS2, PTPN1, XDH |
2.07222 |
|
[CC] GO:0048471 |
perinuclear region of cytoplasm
|
ACHE, AKR1B1, APEX1, APP, CA4, EGFR, ERBB2, HSPA1A, PTGES, SRC, TNKS2, TYR |
2.03249 |
|
[MF] GO:0003824 |
catalytic activity
|
ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CES2, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIM1, POLA1, POLB, PTGES, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TUBB3, TYR, XDH |
15.4162 |
|
[MF] GO:0043167 |
ion binding
|
ABCB1, ABCG2, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH |
14.9847 |
|
[MF] GO:0046914 |
transition metal ion binding
|
ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH |
13.7997 |
|
[MF] GO:0038023 |
signaling receptor activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 |
10.9493 |
|
[MF] GO:0016491 |
oxidoreductase activity
|
AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MAOA, MPO, NQO2, PTGS2, TBXAS1, TYR, XDH |
10.634 |
|
[MF] GO:0060089 |
molecular transducer activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 |
9.97565 |
|
[MF] GO:0004872 |
receptor activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 |
9.71258 |
|
[MF] GO:0004089 |
carbonate dehydratase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
9.31367 |
|
[MF] GO:0004871 |
signal transducer activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, RORC, SMAD3, TEK, TRPV1 |
9.27136 |
|
[MF] GO:0008144 |
drug binding
|
ABCB1, ABCG2, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, ERBB2, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, PPARA, SRC, TEK, TOP1, TOP2A, TRPV1 |
9.1777 |
|
[MF] GO:0004714 |
transmembrane receptor protein tyrosine kinase activity
|
AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK |
9.08892 |
|
[MF] GO:0043169 |
cation binding
|
ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR2A, HTR2B, HTR2C, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
8.44699 |
|
[MF] GO:0019199 |
transmembrane receptor protein kinase activity
|
AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK |
8.15873 |
|
[MF] GO:0048037 |
cofactor binding
|
AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B2, HSD17B1, IDO1, MPO, NQO2, POLA1, PTGES, PTGS2, SRC, TBXAS1, XDH |
8.14426 |
|
[MF] GO:0008227 |
None
|
ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, HTR2A, HTR2B, HTR2C, HTR6 |
8.05082 |
|
[MF] GO:0099600 |
transmembrane receptor activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ERBB2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, TEK, TRPV1 |
8.01334 |
|
[MF] GO:0004888 |
transmembrane signaling receptor activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, EGFR, ERBB2, F3, FLT3, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, TEK, TRPV1 |
8.01334 |
|
[MF] GO:0020037 |
heme binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS2, SRC, TBXAS1 |
7.42398 |
|
[MF] GO:0046906 |
tetrapyrrole binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS2, SRC, TBXAS1 |
7.13042 |
|
[MF] GO:0016835 |
carbon-oxygen lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB |
7.08913 |
|
[MF] GO:0004716 |
signal transducer, downstream of receptor, with protein tyrosine kinase activity
|
EGFR, ERBB2, INSR, KDR, KIT |
6.87676 |
|
[MF] GO:0046872 |
metal ion binding
|
ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH |
6.83106 |
|
[MF] GO:0099528 |
None
|
CHRM1, CHRM2, CHRM4, HTR2A, HTR2B, HTR2C, HTR6 |
6.51981 |
|
[MF] GO:0005506 |
iron ion binding
|
ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH |
6.51981 |
|
[MF] GO:0008270 |
zinc ion binding
|
CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3, TNKS |
6.16293 |
|
[MF] GO:0016614 |
oxidoreductase activity, acting on CH-OH group of donors
|
AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH |
6.09066 |
|
[MF] GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 |
6.01564 |
|
[MF] GO:0004713 |
protein tyrosine kinase activity
|
AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK |
6.01327 |
|
[MF] GO:0016836 |
hydro-lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
5.49096 |
|
[MF] GO:0004497 |
monooxygenase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR |
5.12419 |
|
[MF] GO:0016829 |
lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB |
4.99474 |
|
[MF] GO:0097159 |
organic cyclic compound binding
|
ABCB1, ABCG2, ADORA1, ADRB1, ADRB2, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MPO, MTNR1A, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TUBB3, XDH |
4.85519 |
|
[MF] GO:0004672 |
protein kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 |
4.82804 |
|
[MF] GO:0070330 |
aromatase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 |
4.75619 |
|
[MF] GO:0043168 |
anion binding
|
ABCB1, ABCG2, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MPO, NQO2, NUAK1, PIM1, PTGES, PTPRS, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH |
4.71019 |
|
[MF] GO:0042802 |
identical protein binding
|
ABCG2, ACHE, ADRB2, AOX1, APP, BCL2, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP9, NQO2, PTGS2, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH |
4.63763 |
|
[MF] GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2, TBXAS1, TYR |
4.61966 |
|
[MF] GO:0098531 |
transcription factor activity, direct ligand regulated sequence-specific DNA binding
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC |
4.49303 |
|
[MF] GO:0004879 |
nuclear receptor activity
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC |
4.49303 |
|
[MF] GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.4467 |
|
[MF] GO:0042562 |
hormone binding
|
ACHE, EGFR, HSD17B1, IGF1R, INSR, MTNR1A, NQO2 |
4.31752 |
|
[MF] GO:0005496 |
steroid binding
|
ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC |
4.28659 |
|
[MF] GO:0019899 |
enzyme binding
|
ADRB1, ADRB2, APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, HMGCR, HSPA1A, KIT, MET, MIF, POLA1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A |
4.19817 |
|
[MF] GO:0016772 |
transferase activity, transferring phosphorus-containing groups
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK, TERT, TOP1 |
4.1503 |
|
[MF] GO:0000166 |
nucleotide binding
|
ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, POLA1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH |
4.0792 |
|
[MF] GO:1901265 |
nucleoside phosphate binding
|
ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, POLA1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH |
4.07845 |
|
[MF] GO:0003707 |
steroid hormone receptor activity
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC |
4.0724 |
|
[MF] GO:0036094 |
small molecule binding
|
ABCB1, ABCG2, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIM1, POLA1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH |
3.9937 |
|
[MF] GO:0016773 |
phosphotransferase activity, alcohol group as acceptor
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 |
3.85953 |
|
[MF] GO:0016907 |
None
|
CHRM1, CHRM2, CHRM4 |
3.85841 |
|
[MF] GO:1901363 |
heterocyclic compound binding
|
ABCB1, ABCG2, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MPO, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP1, TOP2A, TRPV1, TUBB3, XDH |
3.83196 |
|
[MF] GO:0032403 |
protein complex binding
|
ACHE, ADORA1, ADRB2, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC |
3.81043 |
|
[MF] GO:0044877 |
macromolecular complex binding
|
ACHE, ADORA1, ADRB2, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC |
3.75878 |
|
[MF] GO:0009055 |
electron transfer activity
|
AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, NQO2, XDH |
3.72688 |
|
[MF] GO:0030594 |
None
|
CHRM1, CHRM2, CHRM4, HTR2A, HTR2B, HTR2C, HTR6 |
3.70335 |
|
[MF] GO:0019902 |
phosphatase binding
|
BCL2, EGFR, ERBB2, HMGCR, MET, PPARA, PTPN1, SMAD3 |
3.55956 |
|
[MF] GO:0019825 |
oxygen binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 |
3.45227 |
|
[MF] GO:0008289 |
lipid binding
|
ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, TRPV1 |
3.43018 |
|
[MF] GO:0016301 |
kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1 |
3.42834 |
|
[MF] GO:0005057 |
signal transducer activity, downstream of receptor
|
ADRB1, EGFR, ERBB2, INSR, KDR, KIT, SMAD3 |
3.42176 |
|
[MF] GO:0004930 |
None
|
ADORA1, ADORA3, ADRB1, ADRB2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, GPR35, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MTNR1A, MTNR1B |
3.35577 |
|
[MF] GO:0004993 |
None
|
HTR2A, HTR2B, HTR2C, HTR6 |
3.2539 |
|
[MF] GO:0099589 |
None
|
HTR2A, HTR2B, HTR2C, HTR6 |
3.2539 |
|
[MF] GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
ALOX15, ALOX5, IDO1, PTGS2 |
3.12153 |
|
[MF] GO:0033764 |
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.06443 |
|
[MF] GO:0016701 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
|
ALOX15, ALOX5, IDO1, PTGS2 |
3.06443 |
|
[MF] GO:0003674 |
molecular_function
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CES2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH |
3.01739 |
|
[MF] GO:0097367 |
carbohydrate derivative binding
|
ABCB1, ABCG2, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MPO, NUAK1, PIM1, POLA1, PTPRS, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 |
2.97325 |
|
[MF] GO:0005524 |
ATP binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, TRPV1 |
2.96774 |
|
[MF] GO:0016229 |
steroid dehydrogenase activity
|
HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
2.96363 |
|
[MF] GO:0046983 |
protein dimerization activity
|
ABCG2, ACHE, ADORA1, ADRB1, ADRB2, AOX1, AXL, BCL2, EGFR, ERBB2, FLT3, HMGCR, KIT, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH |
2.96363 |
|
[MF] GO:0043176 |
None
|
HTR2A, HTR2B, HTR2C |
2.85363 |
|
[MF] GO:0051378 |
None
|
HTR2A, HTR2B, HTR2C |
2.85363 |
|
[MF] GO:0032559 |
adenyl ribonucleotide binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, TRPV1 |
2.85205 |
|
[MF] GO:0030554 |
adenyl nucleotide binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, TRPV1 |
2.81695 |
|
[MF] GO:0038052 |
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
|
ESR1, ESR2 |
2.81647 |
|
[MF] GO:0003845 |
None
|
HSD11B1, HSD11B2 |
2.81647 |
|
[MF] GO:0008389 |
None
|
CYP2A13, CYP2A6 |
2.81647 |
|
[MF] GO:0071886 |
None
|
HTR2A, HTR2C |
2.81647 |
|
[MF] GO:0042803 |
protein homodimerization activity
|
ABCG2, ACHE, ADRB2, AOX1, BCL2, FLT3, HMGCR, KIT, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH |
2.76684 |
|
[MF] GO:0008395 |
steroid hydroxylase activity
|
CYP19A1, CYP1A1, CYP2A13, CYP2A6 |
2.74698 |
|
[MF] GO:0019903 |
protein phosphatase binding
|
BCL2, EGFR, ERBB2, HMGCR, MET, PTPN1 |
2.62129 |
|
[MF] GO:0019838 |
growth factor binding
|
EGFR, ERBB2, IGF1R, INSR, KDR, TEK |
2.42128 |
|
[MF] GO:0008502 |
None
|
MTNR1A, MTNR1B |
2.41815 |
|
[MF] GO:0050473 |
arachidonate 15-lipoxygenase activity
|
ALOX15, PTGS2 |
2.41815 |
|
[MF] GO:0004949 |
None
|
CNR1, CNR2 |
2.41815 |
|
[MF] GO:0004939 |
None
|
ADRB1, ADRB2 |
2.41815 |
|
[MF] GO:0016903 |
None
|
AKR1B1, AKR1B10, AOX1, XDH |
2.37153 |
|
[MF] GO:0015464 |
None
|
CHRM1, CHRM2, CHRM4 |
2.29103 |
|
[MF] GO:0035639 |
purine ribonucleoside triphosphate binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 |
2.19172 |
|
[MF] GO:0001223 |
transcription coactivator binding
|
ESR1, PPARA, TERT |
2.16297 |
|
[MF] GO:0034056 |
estrogen response element binding
|
ESR1, ESR2 |
2.161 |
|
[MF] GO:0051425 |
None
|
APP, INSR |
2.161 |
|
[MF] GO:0042165 |
neurotransmitter binding
|
ACHE, HTR2A, HTR2B, HTR2C |
2.12724 |
|
[MF] GO:0016853 |
None
|
ALOX15, MIF, PTGES, TBXAS1, TOP1, TOP2A |
2.12507 |
|
[MF] GO:0032555 |
purine ribonucleotide binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 |
2.09871 |
|
[MF] GO:0017076 |
purine nucleotide binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 |
2.07222 |
|
[MF] GO:0032553 |
ribonucleotide binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 |
2.06753 |
|
[MF] GO:0140096 |
catalytic activity, acting on a protein
|
AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, ERBB2, F10, F3, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TOP1 |
2.00282 |
