TCM Prescription: Ding Kun Pills



Prescription Description
Prescription IDTCMF3568
Pinyin NameDing Kun Wan
Chinese Name定坤丸
English NameDing Kun Pills
Function Description月经失调, 痛经, 崩漏
IndicationsMetrorrhagia disorder, Dysmenorrhea disorder, Irregular menstruation
Disease ICD-11 Category SB93 [Metrorrhagia disorder (TM1), 崩漏 (TM1) ];
SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2241 Panax quinquefolium 西洋参 TCMH2241 KY120319
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH541 Colla corii asini 阿胶 TCMH541
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1349 Cervus elaphus 鹿茸 TCMH1349 ABMC060-05
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH619 Citrus medica var. sarcodactylis 佛手 TCMH619 ITSAJ4647-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH916 Succinus 琥珀 TCMH916
TCMH746 Carapax et plastrum testudinis 龟甲 TCMH746
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MET, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 13.5212
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 13.5212
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 13.5212
[BP] GO:0042221 response to chemical ABCB1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP1, TRPV1, TYR 12.4776
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 11.7613
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PTGS2, RORC, SRC, TEK, TRPV1, TYR 11.7061
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 11.6748
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, PTGS1, PTGS2, TRPV1 11.6071
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX12, APP, BCL2, CDC25B, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 11.3507
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.0102
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.7559
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.7559
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.5831
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 10.514
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.4425
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2076
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 10.2076
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, HSPA1A, HTR2B, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 10.1724
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP4, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TOP1, TRPV1, TYR 9.84332
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FLT3, HTR5A, NR3C1, PTGS2, RORC, SRC, TEK, TRPV1, TYR 9.8225
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, PTGS2, PTPN1, SRC, TEK, XDH 9.81075
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 9.81075
[BP] GO:0042493 response to drug ABCB1, ADRA1A, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KDR, NR3C1, PTGS2, SRC, TOP1, TRPV1 9.76103
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 9.59239
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.59239
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2A, HTR2B, KDR, PTGS2, SRC, TNKS, TNKS2, TRPV1 9.47857
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 9.13614
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, DRD1, EGFR, FABP3, FLT3, HTR5A, IGF1R, INSR, MMP2, NR3C1, PPARA, PTGS2, SMAD3, SRC, TEK, TRPV1 8.97702
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 8.91233
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 8.54578
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 8.53255
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 8.42563
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TRPV1, TYR 8.40677
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, HTR5A, NR3C1, PTGS2, RORC, SRC, TYR 8.28506
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 8.28094
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA1A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.20061
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 8.14144
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 8.14144
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 8.10145
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.91412
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.74314
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGS1, PTGS2 7.68623
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 7.58543
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 7.54493
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.53292
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 7.52965
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.52746
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, HTR2A, PTGS2 7.4583
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, HTR2A, PTGS2 7.4583
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD2 7.4583
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2 7.43764
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TRPV1, XDH 7.41542
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TRPV1, XDH 7.38464
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 7.37268
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, HTR5A, INSR, NR3C1, PPARA, PTGS2, SRC, TEK, TRPV1 7.35517
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TRPV1 7.20498
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, GPR35, HTR2A, HTR2B, INSR, MET, SMAD3, TRPV1 7.14511
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, INSR, MET, SMAD3, SRC, TRPV1 7.06139
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 7.01218
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR1, CNR2, CXCL8, CYP19A1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, KDR, MET, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK 6.97487
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ALOX12, ALOX15, BCL2, CNR1, CNR2, CXCL8, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 6.9714
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 6.89702
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA1A, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TRPV1, XDH 6.8783
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TRPV1 6.87393
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, TRPV1, XDH 6.87393
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, HCAR2, PTGS2, TNKS, TNKS2 6.85041
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 6.81674
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.8069
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, HTR1A, TYR 6.7675
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TRPV1, TYR 6.7289
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ALOX12, APP, AXL, BCL2, CA2, CNR1, CXCL8, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TRPV1 6.72798
[BP] GO:0007187 None ADORA1, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 6.72272
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 6.69205
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.6552
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.6552
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, PTGS2, RORC, SRC, TEK 6.57278
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A 6.52045
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ALOX12, APP, CNR1, CNR2, CYP19A1, DRD2, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 6.51712
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TRPV1, TYR 6.47059
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, RORC, SIGMAR1, SMAD3, SRC, TEK, TNKS2, TYR 6.44443
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.42706
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 6.42215
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PTGS2, RORC, SMAD3, SRC, TRPV1 6.39686
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 6.35907
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.34108
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.30894
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, BCL2, CNR2, CXCL8, DRD1, DRD2, DRD3, DUSP3, EGFR, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 6.27965
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 6.27965
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, BCL2, CNR2, CXCL8, DRD1, DRD2, DRD3, DUSP3, EGFR, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 6.25778
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.24901
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.16568
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 6.16206
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.0975
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.0975
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 6.0885
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX12, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 6.08438
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 6.084
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, PTPN1, SRC, TEK 6.06397
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CXCL8, CYP1A1, CYP1B1, DRD1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, PTGS2, RORC, SMAD3, SRC, TRPV1 6.05205
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 6.02616
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TRPV1, TYR 6.0141
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 6.00895
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 6.00895
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 5.8608
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, HTR2A, PTGS2 5.79462
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 5.78197
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 5.75619
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 5.75431
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, APP, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, PTPN1, SRC, TEK, XDH 5.71141
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 5.70258
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, HTR2B, INSR, MMP12, PTGS2, SMAD3, SRC, TRPV1 5.68111
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.66037
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.66037
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.58764
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 5.58764
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR2A, PTGS2 5.58306
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 5.58306
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, DRD3, GPR35, HTR2A, MMP9, PTGS2 5.57137
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, HSPA1A 5.55676
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2, TRPV1 5.49977
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.45636
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, EGFR, HTR2A, HTR2B, KDR, SRC, TEK 5.43805
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, INSR, PTGS2, SMAD3, TRPV1 5.42387
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AXL, BCL2, CA1, CA2, CNR1, CNR2, CSNK2A1, CXCL8, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 5.41038
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, APP, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 5.39293
[BP] GO:0008217 None ADORA1, ADRA1A, CNR1, DRD2, DRD3, PPARA, PTGS1, PTGS2, SMAD3 5.38668
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSD11B1, HSD17B2, HTR5A, INSR, KDR, MMP9, PIM1, PPARA, PTGS2, PTPRS, RORC, SIGMAR1, SMAD3, SRC, TEK, TYR 5.37265
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.31996
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 5.31996
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TUBB3, TYR, XDH 5.26341
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 5.26258
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 5.25722
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 5.24608
[BP] GO:0007188 None ADORA1, ADRA1A, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.23911
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 5.15507
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, PTGS1, RORC 5.14016
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 5.14015
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 5.12219
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, DRD1, DRD2, DRD3, PPARA, PTPRS, SMAD3, TEK 5.07048
[BP] GO:0050801 ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, FABP3, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 5.06463
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ALOX12, APP, AXL, BCL2, CA2, CNR1, CXCL8, CYP1B1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, MMP12, MMP9, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 5.0549
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 5.04855
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, HTR2A, MET, TRPV1 5.03979
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, CNR1, CNR2, CXCL8, DRD1, DRD2, DRD3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, SIGMAR1, SRC 5.03666
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, NR3C1, PTGS2, RORC, SRC, TRPV1 5.01944
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, HTR7, PPARA, RORC, SRC, TOP1 5.00867
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 4.94787
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, PTGS2, SRC, TEK 4.91096
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 4.87456
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 4.86922
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, CNR1, DRD1, DRD2, DRD3, GPR35, HTR1A, HTR2A, MMP9, PTGS2 4.83244
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 4.77033
[BP] GO:0007610 None APP, BCL2, CNR1, DRD1, DRD2, DRD3, EGFR, HTR1A, HTR2A, HTR2B, INSR, PPARA, PTGS2, TRPV1 4.67154
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.65501
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.63729
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.63609
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.58263
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 4.564
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 4.55131
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 4.54082
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2 4.53888
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, HTR2A, HTR2B, HTR7, INSR, PTGS2, SRC, TEK, TRPV1, TYR 4.52873
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 4.49857
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 4.47328
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, DRD2, DRD3, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.4393
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.4393
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CXCL8, CYP1B1, DRD1, EGFR, IGF1R, INSR, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC, TRPV1 4.4284
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.40551
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.40551
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.40551
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 4.40551
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1 4.34565
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.33418
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, EGFR, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 4.27752
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.27166
[BP] GO:0050890 None ADORA1, APP, CNR1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, PTGS2 4.27166
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.27166
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 4.27145
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.26855
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.26365
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 4.19428
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.16871
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.15827
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 4.14753
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, NR3C1, PTGS2, SRC, TRPV1 4.14753
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2 4.14753
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.14753
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, DUSP3, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.14299
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.0634
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.04147
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.03162
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.028
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 4.02084
[BP] GO:0055080 cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 3.96888
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 3.96287
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.94465
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.94465
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.9297
[BP] GO:0016477 cell migration AXL, CNR2, CXCL8, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 3.90513
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 3.89989
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, DRD3, HTR2A 3.89989
[BP] GO:0045776 None ADORA1, CNR1, DRD2, DRD3, PPARA 3.89989
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, CXCL8, DRD1, DRD2, DRD3, EGFR, HTR2B, HTR5A, KDR 3.8904
[BP] GO:0007611 None APP, CNR1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, PTGS2 3.8904
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.8904
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 3.87417
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC, TRPV1 3.8665
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PTGS1, PTGS2 3.85782
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, FABP4, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 3.82226
[BP] GO:0006811 None ABCB1, ADRA1A, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA, TRPV1 3.81443
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 3.80014
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 3.80002
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.79987
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.79987
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.78394
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.77763
[BP] GO:0071363 cellular response to growth factor stimulus APP, CXCL8, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.76692
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 3.76692
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.76525
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 3.75928
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 3.71876
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, PTGS2, PTPN1, SRC, TEK, XDH 3.70382
[BP] GO:0042391 None ADORA1, ADRA1A, APP, BCL2, CNR1, CNR2, DRD1, GPR35, KDR, SRC, TRPV1 3.70097
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.69131
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP1 3.66969
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 3.65405
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, CXCL8, DRD1, EGFR, FLT3, IGF1R, INSR, MMP2, NR3C1, PTGS2, SMAD3, SRC, TRPV1 3.60345
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, PPARA, RORC, TOP1 3.58521
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.58521
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.58286
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.56818
[BP] GO:2001023 None CNR1, DRD1, DRD2, DRD3, HTR2A, MET 3.55223
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, CXCL8, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 3.54658
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, HTR2B, MET, PPARA, SMAD3 3.54306
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 3.52842
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC, TEK, TNKS 3.52265
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 3.512
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.49475
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.49089
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.49089
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TNKS 3.4842
[BP] GO:0040011 locomotion AXL, CNR2, CXCL8, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 3.48054
[BP] GO:0006928 movement of cell or subcellular component ALOX12, APP, AXL, CNR2, CXCL8, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PTGS2, SRC, TEK, TUBB3 3.47254
[BP] GO:0048870 cell motility AXL, CNR2, CXCL8, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 3.45464
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CNR1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC 3.44476
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, DRD2, DRD3, EGFR, GPR35, HCAR2, HTR2A, PTGS2, SMAD3, TRPV1 3.43388
[BP] GO:0050927 None CXCL8, F3, KDR, SMAD3 3.42939
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 3.42939
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.4169
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.4169
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.4169
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, NR3C1 3.4169
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, BCL2, CXCL8, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK 3.40968
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, XDH 3.4025
[BP] GO:0031623 None ACHE, CXCL8, DRD2, DRD3, HTR2B 3.40028
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC, TOP1 3.40028
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 3.39506
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.38772
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 3.38592
[BP] GO:0050926 None CXCL8, F3, KDR, SMAD3 3.38082
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.38082
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, CXCL8, EGFR, F3, FABP4, KDR, MET, PTGS2, SMAD3 3.38082
[BP] GO:0070848 response to growth factor APP, CXCL8, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.38082
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CDC25B, CSNK2A1, CXCL8, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TNKS 3.37362
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1 3.35973
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.33941
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.33433
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, PTGS2, TYR 3.31438
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.31407
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC, TRPV1 3.31407
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CXCL8, CYP1B1, F3, KDR, PTGS2, TEK 3.29954
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.29954
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.29954
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.29954
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.29954
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, BCL2, CXCL8, DRD2, DRD3, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 3.29954
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, NR3C1, PTGS2, SRC 3.28506
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.28506
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 3.28212
[BP] GO:0014059 None CNR1, DRD2, DRD3, HTR2A 3.27535
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, EGFR, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 3.27333
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, NR3C1, PTGS2, SRC 3.27247
[BP] GO:0090066 None ADORA1, ADRA1A, ALOX15, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 3.27232
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC, TEK 3.27232
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.25311
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.241
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 3.22129
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, INSR, PTGS2 3.22092
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 3.21199
[BP] GO:0040008 regulation of growth ALOX12, APP, BCL2, CSNK2A1, DRD2, DRD3, EGFR, HSPA1A, INSR, PIM1, PTPRS, SMAD3, TNKS2 3.19843
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 3.19843
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, HTR1A, MET, PIM1, SRC, TEK, TYR 3.1926
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, XDH 3.16204
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS 3.15992
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.15923
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.15538
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.15538
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B, TRPV1 3.13532
[BP] GO:0045744 None CXCL8, DRD2, DRD3, MET 3.11821
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, FABP4, PPARA, PTGS2, SMAD3, TEK 3.10386
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.06617
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.06536
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, TNKS2 3.04426
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC, TRPV1 3.04161
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, BCL2, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 3.03475
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.0329
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.0329
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.03246
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CNR1, CXCL8, CYP1B1, DRD2, DRD3, EGFR, F3, HTR2A, INSR, KDR, NUAK1, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 3.02492
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, MMP12, SRC 3.02492
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, SMAD3, TEK 3.02492
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.02492
[BP] GO:0045907 None ADRA1A, EGFR, HTR2A, PTGS2 3.02492
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 3.01457
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1 3.01091
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK, TNKS 3.01091
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.01039
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CXCL8, CYP1B1, F3, KDR, PTGS2, TEK 2.99592
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CNR1, CXCL8, CYP1B1, DRD2, F3, HTR2A, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK 2.9827
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, CNR1, DRD2, DRD3, GPR35, HSPA1A, HTR2A, MMP9, PTGS2 2.96448
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CNR1, CNR2, CYP19A1, DRD2, DUSP3, MMP12, PTPRS 2.96223
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CXCL8, CYP19A1, DRD2, DUSP3, HCAR2, HSPA1A, MMP12, MMP2, PTPN1, PTPRS, SMAD3, SRC 2.94896
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, EGFR, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.94269
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, ALPL, AXL, BCL2, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, DRD3, EGFR, HTR2A, MMP12, PTGS2, SMAD3, SRC, TRPV1, TYR 2.94208
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.9379
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.9379
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.9379
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.93228
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.93228
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.93228
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, BCL2, CXCL8, CYP1B1, DRD2, FABP3, HSPA1A, PTGS2, SMAD3, XDH 2.91857
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 2.90153
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.89712
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.86711
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.85662
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.85561
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 2.84588
[BP] GO:0070201 None ACHE, APP, BCL2, CNR1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.84588
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, EGFR, HCAR2, HTR2B, MMP12, PTGS2, SMAD3, SRC 2.84588
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.84588
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.84588
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.84588
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 2.84451
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.83484
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B, TRPV1 2.83484
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 2.82254
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC, TRPV1 2.80248
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A 2.78726
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 2.7776
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 2.7776
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, PTGS2, SRC, TRPV1, TYR 2.77238
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, PTGS2, TRPV1, TYR 2.76874
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.75607
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.75607
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.75607
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.73818
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.71548
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.6894
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.6894
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, INSR, PTGS2 2.67622
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.66971
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.66971
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.66971
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.64496
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, NR3C1, PTGS2 2.62938
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.62938
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.62938
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC, TEK 2.62829
[BP] GO:0002791 None ACHE, ADORA1, CNR1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 2.62586
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, BCL2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, PTGS2, TEK, TRPV1 2.62527
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.62217
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.61763
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.61074
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CSNK2A1, DRD2, DRD3, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.59795
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.59737
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.59379
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B 2.58443
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 2.57159
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, TRPV1 2.56428
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, TRPV1 2.56428
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.56428
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.55903
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.53063
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CXCL8, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.52652
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.52652
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 2.52652
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.52652
[BP] GO:0060160 None DRD2, DRD3 2.52652
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52652
[BP] GO:0033602 None CNR1, DRD2 2.52652
[BP] GO:0050877 None ADORA1, APP, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR, PTGS2, TRPV1, TYR 2.52569
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.51443
[BP] GO:0051223 None ACHE, APP, CNR1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.51079
[BP] GO:0050433 None CNR1, DRD2, DRD3, HTR2A 2.51074
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, GPR35, HTR2A, HTR2B, SMAD3, TRPV1 2.49205
[BP] GO:0009266 None ADORA1, HSPA1A, HTR2A, HTR2B, PTGS2, TRPV1 2.48467
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.47903
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CNR1, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, FABP4, HSPA1A, HTR2B, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 2.47431
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.46589
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CNR1, CSNK2A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.45567
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.44808
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, DRD2, EGFR, HCAR2, HTR2B, MMP12, PTGS2, SMAD3, SRC 2.44401
[BP] GO:0043112 None ACHE, CXCL8, DRD2, DRD3, HTR2B 2.43793
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2 2.41718
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, DRD1, DRD2, DRD3, EGFR, F10, FABP3, HSPA1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SRC, TNKS, TRPV1, XDH 2.40287
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.40162
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.40162
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.40162
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, XDH 2.39587
[BP] GO:0022898 None ABCB1, APP, BCL2, DRD2, DRD3, GPR35, MMP9 2.3808
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.3808
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.38076
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.37679
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.35859
[BP] GO:0048638 regulation of developmental growth APP, BCL2, DRD2, DRD3, INSR, PIM1, PTPRS, TNKS2 2.35389
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, HTR2A, PTPN1, SRC 2.3521
[BP] GO:0007568 aging ADRA1A, AURKB, BCL2, CNR1, CYP1A1, HTR2A, PTGS2 2.3521
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.347
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.34552
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2 2.34037
[BP] GO:0098900 None ADRA1A, CNR1, CNR2, GPR35 2.33635
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.33635
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.33635
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.3301
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.32991
[BP] GO:0051336 regulation of hydrolase activity ADRA1A, APP, CSNK2A1, DRD2, EGFR, F3, HSPA1A, HTR2A, HTR2B, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, XDH 2.32219
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, PTGS2, SRC, TRPV1, TYR 2.32203
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.31883
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PTPN1, SRC 2.31287
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.31287
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.31287
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.31072
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.30394
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, HCAR2, MMP9, PTGS2, SMAD3, SRC, TRPV1, XDH 2.30394
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, SRC, TNKS, TOP1 2.29845
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.29845
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.29845
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.29845
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TNKS 2.28986
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.28986
[BP] GO:0070213 None TNKS, TNKS2 2.28549
[BP] GO:0038171 None CNR1, CNR2 2.28549
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28549
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.28179
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, DRD1, DRD2, DRD3, F10, FABP3, HSPA1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SRC, TNKS, TRPV1, XDH 2.28179
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, HCAR2, MMP9, PTGS2, SMAD3, SRC, TRPV1, XDH 2.27874
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TUBB3, TYR, XDH 2.27636
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.26214
[BP] GO:0032409 None ABCB1, APP, BCL2, DRD2, DRD3, GPR35, MMP9 2.26214
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.26214
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, CXCL8, EGFR, FLT3, FUT7, HSPA1A, MMP9, RORC, SMAD3, SRC, TRPV1 2.25959
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 2.25959
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.25233
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, APP, AXL, CXCL8, DRD2, DRD3, HTR2B, TRPV1 2.24745
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, TRPV1 2.24597
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.24597
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.22947
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.22461
[BP] GO:0050678 None EGFR, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH 2.22195
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, PTGS2, TYR 2.22006
[BP] GO:1901342 regulation of vasculature development ALOX12, CXCL8, CYP1B1, F3, KDR, PTGS2, TEK, XDH 2.21452
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC 2.20826
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, GPR35, HTR2A, HTR2B, TRPV1 2.2078
[BP] GO:0050708 None ACHE, CNR1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 2.2078
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, DRD1, DRD2, DRD3, EGFR, F10, FABP3, HSPA1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SRC, TNKS, TNKS2, TRPV1, XDH 2.20478
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.20478
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.20478
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20478
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.20316
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.19916
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.19916
[BP] GO:0050679 None EGFR, F3, HTR2B, KDR, MMP12, TEK 2.19083
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, ADRA1A, ALOX12, APP, AXL, BCL2, DRD2, DRD3, EGFR, GPR35, PTGS2, PTPRS, SMAD3, TEK, XDH 2.18804
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.17378
[BP] GO:0019229 None ADRA1A, EGFR, HTR2A, PTGS2 2.17378
[BP] GO:0051894 None KDR, SMAD3, TEK 2.15604
[BP] GO:0061900 None APP, EGFR, TRPV1 2.15604
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.15604
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.15604
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, TRPV1 2.15495
[BP] GO:0045927 positive regulation of growth ALOX12, BCL2, CSNK2A1, DRD2, EGFR, INSR, PIM1 2.14676
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4 2.13929
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, CXCL8, PTGS1, PTGS2, TRPV1 2.13929
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.12597
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 2.11349
[BP] GO:0034762 None ABCB1, APP, BCL2, CA2, DRD1, DRD2, DRD3, GPR35, MMP9 2.11349
[BP] GO:0050920 regulation of chemotaxis CXCL8, CYP19A1, F3, KDR, MET, SMAD3 2.11225
[BP] GO:0021853 None DRD1, DRD2 2.11225
[BP] GO:0010641 None F3, SRC 2.11225
[BP] GO:0090325 None DRD2, DRD3 2.11225
[BP] GO:0007598 None F10, F3 2.11225
[BP] GO:0071502 None HTR2B, TRPV1 2.11225
[BP] GO:1904936 None DRD1, DRD2 2.11225
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.11225
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.11225
[BP] GO:0042321 None ADORA1, DRD2 2.11225
[BP] GO:0010513 None HTR2A, HTR2B 2.11225
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, PTPRS, XDH 2.10937
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, SRC, TNKS, TOP1 2.09728
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, PTGS2 2.08865
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.08865
[BP] GO:2000026 regulation of multicellular organismal development ALOX12, APP, AXL, BCL2, CA2, CNR1, CXCL8, CYP1B1, DRD2, DRD3, EGFR, F3, INSR, KDR, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, XDH 2.0878
[BP] GO:0043086 negative regulation of catalytic activity APP, CNR1, CNR2, CSNK2A1, DRD2, DRD3, DUSP3, FABP4, IGF1R, MMP9, PTGS2, PTPN1, SRC 2.08394
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PTPN1, SRC 2.07789
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.07641
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.07641
[BP] GO:1903393 None KDR, SMAD3, TEK 2.07641
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.06973
[BP] GO:0051926 negative regulation of calcium ion transport BCL2, DRD2, GPR35, PTGS2 2.06973
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, SMAD3, SRC, TEK 2.05619
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, HCAR2, MMP9, PTGS2, SMAD3, SRC, TRPV1, XDH 2.05179
[BP] GO:0010959 None ADORA1, BCL2, DRD1, DRD2, DRD3, GPR35, HTR2A, PTGS2 2.05177
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.04495
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.03419
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.03419
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.02525
[BP] GO:0045913 None HTR2A, INSR, PPARA, SRC 2.00185
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.00185
[BP] GO:0006897 endocytosis ACHE, ADORA1, ALOX15, APP, AXL, CXCL8, DRD2, DRD3, HTR2B 2.00009
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CA4, CNR1, CNR2, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, TEK, TRPV1 8.35027
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA1A, ALOX15, APP, AXL, CA2, CA4, CA9, CNR1, CNR2, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTGS2, PTPRS, SIGMAR1, SRC, TEK, TRPV1 7.3082
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, TEK, TRPV1 6.81674
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR 6.18728
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TRPV1 5.62364
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SRC, TEK, TRPV1, TYR 5.32297
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA1A, CA2, CA4, CA9, CNR1, DRD1, DRD2, EGFR, HTR2A, INSR, MET, PTGS2, SIGMAR1, SRC, TEK, TRPV1 4.29752
[CC] GO:0045121 membrane raft ADRA1A, APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 4.01011
[CC] GO:0098857 membrane microdomain ADRA1A, APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.98518
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, F10, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1, SIGMAR1 3.86951
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, HSD11B1, HSD17B2, PTGS1, PTGS2, SIGMAR1 3.4501
[CC] GO:0098589 membrane region ADRA1A, APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.38913
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR5A, INSR, KDR, MMP2, MMP9, NR3C1, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SIGMAR1, SMAD3, SRC, TNKS, TNKS2, TOP1, TRPV1, TYR, XDH 2.96448
[CC] GO:0005901 caveola ADRA1A, HTR2A, INSR, PTGS2, SRC 2.94861
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CNR1, CNR2, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, HTR6, PTGS2, PTPRS, SRC, TEK, TUBB3 2.53256
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CNR1, CNR2, CYP3A4, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, TEK, TRPV1, TYR 2.52428
[CC] GO:0044853 plasma membrane raft ADRA1A, HTR2A, INSR, PTGS2, SRC 2.51443
[CC] GO:0097458 None ADORA1, APP, CA2, CNR1, CNR2, DRD2, HTR2A, HTR2B, HTR5A, INSR, PTGS1, PTGS2, PTPRS, SIGMAR1, SRC, TOP1, TRPV1, TUBB3 2.49274
[CC] GO:0043005 None ADORA1, APP, CA2, CNR1, CNR2, DRD2, HTR2A, HTR2B, HTR5A, PTGS2, PTPRS, SRC, TUBB3 2.45774
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CNR1, CNR2, DRD1, DRD2, HTR2A, HTR2B, HTR5A, HTR6, PTGS2, PTPRS, SRC, TEK, TUBB3 2.3521
[CC] GO:0031233 None CA4, F10, F3 2.34552
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, INSR, SRC, TRPV1 2.32751
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, HSPA1A, HTR5A, KDR, PTGS2, PTPN1, SIGMAR1, XDH 2.32093
[CC] GO:0030424 None APP, CA2, CNR1, DRD2, HTR2A, PTPRS, TUBB3 2.12823
[CC] GO:0043204 None CNR2, DRD2, HTR5A, PTPRS, TOP1 2.12383
[CC] GO:0031090 None ADRA1A, ALOX5, APP, BCL2, CA4, CNR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, FUT7, INSR, PTGS1, PTGS2, SIGMAR1, SMAD3, SRC, TNKS, TNKS2, TYR 2.11225
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.07641
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.7336
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 15.5148
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TUBB3, TYR, XDH 15.5148
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 11.2668
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1724
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, F10, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TRPV1, TYR, XDH 9.91315
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 9.76103
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SIGMAR1, TEK, TRPV1 9.68498
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SIGMAR1, SRC, TEK, TOP1, TRPV1 9.484
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.97085
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SIGMAR1, TEK, TRPV1 8.46678
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK, TRPV1 8.39599
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK, TRPV1 8.39599
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.39599
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, XDH 8.31896
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SIGMAR1, SMAD3, TEK, TRPV1 8.23367
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, NR3C1, PPARA, RORC, SIGMAR1, TEK, TRPV1 8.22881
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PTGS1, PTGS2, TYR, XDH 8.22881
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 8.14144
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 7.81862
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.74314
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 7.37268
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.2193
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.953
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TYR 6.86086
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.72272
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.72272
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.6552
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.6552
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.5299
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.42215
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.24901
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SMAD3, TNKS 6.08438
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.79466
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.68142
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.54065
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, F10, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TRPV1, TYR, XDH 5.38364
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.78152
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.73141
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, PTGS1, PTGS2, SRC, XDH 4.42965
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CNR1, CNR2, DRD1, DRD2, DRD3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.31391
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.80109
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NR3C1 3.65686
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 3.58521
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.38082
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.32115
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.28506
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.28506
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.13532
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.03475
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.99592
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 2.95486
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.9379
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.93228
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.93228
[MF] GO:0008389 None CYP2A13, CYP2A6 2.93228
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.84588
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.67967
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TRPV1, TUBB3, XDH 2.55733
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.52652
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.52652
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.52652
[MF] GO:0004949 None CNR1, CNR2 2.52652
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.52652
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.52652
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, F10, F3, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 2.49538
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TOP1, TRPV1, TUBB3, XDH 2.37985
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.34552
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.30903
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.28549
[MF] GO:0051425 None APP, INSR 2.28549
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.28549
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.27756
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TRPV1, TUBB3, TYR, XDH 2.27636
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.11225
[MF] GO:0043559 insulin binding IGF1R, INSR 2.11225
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.11225
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.07042
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK, TOP1 2.04495
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.03419


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.2129
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX15, HTR2B, HTR1A, ALOX12, HTR2A, PTGS2, HTR5A, PTGS1, HTR6, HTR7, CYP2D6, ALOX5 12.6245
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, HTR2B, HTR1A, TRPV1, HTR2A, NR3C1, HTR5A, ADRA1A, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1, DRD1, DRD2, DRD3 12.5072
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.3666
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.9119
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 8.5255
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.3532
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.5409
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9, EGFR 6.3091
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.2397
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 5.2397
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, HTR2B, HTR2A, DRD1, DRD2, EGFR 5.6548
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 5.2933
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, CXCL8, FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, EGFR, IGF1R 4.7783
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, EGFR 4.7921
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, CXCL8, MMP2, BCL2, PIM1, F3 4.2539
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.1925
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2, PTGS1 4.3083
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 3.5564
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 3.5904
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.2698
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, ALOX12, TRPV1, HTR2A 3.2541
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.2517
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.9867
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.1877
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 2.8219
Hepatitis B_Homo sapiens_hsa05161 SMAD3, CXCL8, SRC, BCL2, MMP9 2.6038
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 2.4121
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET, EGFR 2.8523
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 2.9066
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, CYP3A4 2.8523
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8523
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 2.2566
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, BCL2, PTGS2 2.4263
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 1.9241
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA1A 1.6302
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET, EGFR 1.6302
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 1.9702
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9241
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.8359
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.8867
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.6007
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6005
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.4129
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1, TEK 1.6005
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 1.8359
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.329
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.3175
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.2642
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, ADRA1A, IGF1R 1.2877
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.1625
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA, EGFR 1.2376
Phospholipase D signaling pathway_Homo sapiens_hsa04072 CXCL8, INSR, EGFR 1.1693
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, INSR, PPARA 1.1367
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.4426
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.1158
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.3012
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.8996
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1612
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.7838
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 0.7233
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8545
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.7823
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.6708
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2154
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9176
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, CXCL8 0.8204
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8804
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7165
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 0.8371
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2405
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6708
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7426
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6708
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2518
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6708
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8996
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5771
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.6708
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1A 0.6467
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.6142
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2624
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6708
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 0.9205
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2854
Influenza A_Homo sapiens_hsa05164 CXCL8, HSPA1A 0.5621
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2854
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5552
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5552
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.4779
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3089
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3198
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9842
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC 0.5382
Axon guidance_Homo sapiens_hsa04360 MET 0.3341
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3468
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3416
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9805
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3468
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3468
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1693
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1158
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.3792
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.8219
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3928
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.3928
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3928
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3928
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1097
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3986
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.1286
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.398
Legionellosis_Homo sapiens_hsa05134 CXCL8, HSPA1A 1.1847
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4184
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4239
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4184
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.423
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4184
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1158
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.4184
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1553
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4184
Peroxisome_Homo sapiens_hsa04146 XDH 0.4239
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4537
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.1158
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4537
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4537
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4522
Pertussis_Homo sapiens_hsa05133 CXCL8 0.4506
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4444
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4588
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.2642
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.2642
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.4588
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4701
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.468
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4779
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.495
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.5109
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5139
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.517
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5348
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5382
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5542
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6005
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5724
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6117
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4651
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5556
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6467
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7027
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6708
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.6467
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7739
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7086
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6708
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7027
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0025
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9038


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)