TCM-ID Prescription

Prescription Description

Prescription ID	TCMFx1043
Pinyin Name	Jin Tong Xiao Ding
Chinese Name	筋痛消酊
English Name	Jin Tong Xiao Tincture
Function Description	急性闭合性软组织损伤
Indications	None
Disease ICD-11 Category
Human Tissues Associated with Indication	SkeletaMuscle
Reference	Chinese pharmacopoeia (2015)
Reference Book/link	ISBN 978-7-5067-7337-9

Prescription Components

Component ID	Latin Name	Chinese Name	Component Quantity	Barcode
TCMH1753	Boswellia carterii	乳香	TCMH1753
TCMH1508	Commiphora myrrha	没药	TCMH1508	MH522406
TCMH363	Rheum officinale	大黄	TCMH363	ITSAJ4685-14
TCMH865	Carthamus tinctorius	红花	TCMH865	ITSAI2447-14
TCMH2718	Pyritum	自然铜	TCMH2718
TCMH1768	Panax notoginseng	三七	TCMH1768	ITSAO2360-14
TCMH2348	Sanguis draconis	血竭	TCMH2348
TCMH305	Cnidium officinale	川芎	TCMH305	ITSAP4207-14
TCMH2532	Curcuma aromatica	郁金	TCMH2532	ITSAF2298-14
TCMH421	Angelica sinensis	当归	TCMH421	ITSAF173-14
TCMH2641	Gardenia jasminoides	栀子	TCMH2641	ITSAJ4473-14
TCMH1302	Herba artemisiae anomalae	刘寄奴	TCMH1302	ITSAJ4294-14
TCMH2716	Cercis chinensis bunge	紫荆皮	TCMH2716
TCMH547	Catechu	儿茶	TCMH547
TCMH118	Angelica dahurica	白芷	TCMH118	ITSAK3312-14
TCMH1742	Cinnamomum cassia	肉桂	TCMH1742	GQ255631
TCMH562	Saposhnikovia divaricata	防风	TCMH562	ITSAE3225-14
TCMH1533	Saussurea lappa	木香	TCMH1533
TCMH2265	Cyperus rotundus	香附	TCMH2265	GENG1049-15
TCMH890	Cortex magnoliae officinalis	厚朴	TCMH890	ITSAM1591-14
TCMH2295	fructus foeniculi	小茴香	TCMH2295
TCMH296	Radix aconiti	川乌	TCMH296
TCMH222	Aconitum carmichaelii	草乌	TCMH222	ITSAH2410-14
TCMH2596	Fritillaria verticillata	浙贝母	TCMH2596
TCMH2094	Arisaema consanguineum	天南星	TCMH2094	GBVY604-14
TCMH1518	Chaenomeles sinensis	木瓜	TCMH1518	GBVJ2053-11, GBVJ2052-11
TCMH2585	Cinnamomum camphora	樟脑	TCMH2585	SDH069-14
TCMH183	Dryobalanops aromatica	冰片	TCMH183	GBVK4926-11
TCMH1511	Momordica cochinchinensis	木鳖子	TCMH1511	ITSAJ4256-14
TCMH1665	Notopterygium incisum	羌活	TCMH1665	JF755946
TCMH243	Pericarpium citri reticulatae	陈皮	TCMH243

Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT101	PTPN1	Protein-tyrosine phosphatase 1B	Hydrolase	P18031
TCMT102	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Hydrolase	P24666
TCMT103	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	Hydrolase	P10586
TCMT112	ADORA3	Adenosine A3 receptor	GPCR	P0DMS8
TCMT114	CNR2	Cannabinoid CB2 receptor	GPCR	P34972
TCMT115	CNR1	Cannabinoid CB1 receptor	GPCR	P21554
TCMT126	TERT	Telomerase reverse transcriptase	Transferase	O14746
TCMT13	APEX1	DNA-(apurinic or apyrimidinic site) lyase	Lyase	P27695
TCMT130	ALOX5	Arachidonate 5-lipoxygenase	Oxidoreductase	P09917
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT133	CA1	Carbonic anhydrase I	Lyase	P00915
TCMT134	CA2	Carbonic anhydrase II	Lyase	P00918
TCMT135	CA14	Carbonic anhydrase XIV	Lyase	Q9ULX7
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT137	CA9	Carbonic anhydrase IX	Lyase	Q16790
TCMT138	CA7	Carbonic anhydrase VII	Lyase	P43166
TCMT139	CA6	Carbonic anhydrase VI	Lyase	P23280
TCMT140	CA5B	Carbonic anhydrase VB	Lyase	Q9Y2D0
TCMT141	CA5A	Carbonic anhydrase VA	Lyase	P35218
TCMT142	CA4	Carbonic anhydrase IV	Lyase	P22748
TCMT150	RORC	Nuclear receptor ROR-gamma	Nuclear receptor	P51449
TCMT151	PRKCA	Protein kinase C alpha	Kinase	P17252
TCMT152	PRKCB	Protein kinase C beta	Kinase	P05771
TCMT153	PRKCG	Protein kinase C gamma	Kinase	P05129
TCMT154	PRKCD	Protein kinase C delta	Kinase	Q05655
TCMT155	PRKCE	Protein kinase C epsilon	Kinase	Q02156
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT159	TYR	Tyrosinase	Oxidoreductase	P14679
TCMT160	HTR7	Serotonin 7 (5-HT7) receptor	GPCR	P34969
TCMT161	HCAR2	Hydroxycarboxylic acid receptor 2	GPCR	Q8TDS4
TCMT162	UGT1A1	UDP-glucuronosyltransferase 1-1	Transferase	P22309
TCMT164	PTGS1	Cyclooxygenase-1	Oxidoreductase	P23219
TCMT17	POLB	DNA polymerase beta	Transferase	P06746
TCMT174	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	Oxidoreductase	P28845
TCMT187	AR	Androgen Receptor	Nuclear receptor	P10275
TCMT190	PTPN2	T-cell protein-tyrosine phosphatase	Hydrolase	P17706
TCMT193	RELA	Nuclear factor NF-kappa-B p65 subunit	Transcription factor	Q04206
TCMT194	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Kinase	O43318
TCMT195	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Kinase	Q02750
TCMT196	MAP2K7	Dual specificity mitogen-activated protein kinase kinase 7	Kinase	O14733
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT206	CYP2A6	Cytochrome P450 2A6	Oxidoreductase	P11509
TCMT207	BACE1	Beta-secretase 1	Protease	P56817
TCMT208	MAOA	Monoamine oxidase A	Oxidoreductase	P21397
TCMT209	HSD11B2	11-beta-hydroxysteroid dehydrogenase 2	Oxidoreductase	P80365
TCMT212	SRC	Tyrosine-protein kinase SRC	Kinase	P12931
TCMT213	SLC22A1	Solute carrier family 22 member 1	Transporter	O15245
TCMT215	CYP1A1	Cytochrome P450 1A1	Oxidoreductase	P04798
TCMT217	CYP2C8	Cytochrome P450 2C8	Oxidoreductase	P10632
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT23	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Hydrolase	P05186
TCMT230	HSD17B3	Estradiol 17-beta-dehydrogenase 3	Oxidoreductase	P37058
TCMT232	ABCB1	P-glycoprotein 1	Transporter	P08183
TCMT239	PIM1	Serine/threonine-protein kinase PIM1	Kinase	P11309
TCMT257	CYP1B1	Cytochrome P450 1B1	Oxidoreductase	Q16678
TCMT260	FLT3	Tyrosine-protein kinase receptor FLT3	Kinase	P36888
TCMT261	DAPK1	Death-associated protein kinase 1	Kinase	P53355
TCMT268	CYP2A13	Cytochrome P450 2A13	Oxidoreductase	Q16696
TCMT280	AKR1B10	Aldo-keto reductase family 1 member B10	Oxidoreductase	O60218
TCMT289	TBXAS1	Thromboxane-A synthase	Isomerase	P24557
TCMT295	MMP1	Matrix metalloproteinase-1	Hydrolase	P03956
TCMT296	ADORA1	Adenosine A1 receptor	GPCR	P30542
TCMT297	FABP4	Fatty acid binding protein adipocyte	Unclassified	P15090
TCMT298	FABP3	Fatty acid binding protein muscle	Hydrolase	P05413
TCMT3	ALOX15	Arachidonate 15-lipoxygenase	Oxidoreductase	P16050
TCMT30	PTGS2	Cyclooxygenase-2	Oxidoreductase	P35354
TCMT301	PTGES	Prostaglandin E synthase	Isomerase	O14684
TCMT304	MMP14	Matrix metalloproteinase 14	Hydrolase	P50281
TCMT306	MMP2	Matrix metalloproteinase-2	Hydrolase	P08253
TCMT309	SLC22A2	Solute carrier family 22 member 2	Transporter	O15244
TCMT310	SLC47A2	Multidrug and toxin extrusion protein 2	Transporter	Q86VL8
TCMT311	SLC47A1	Multidrug and toxin extrusion protein 1	Transporter	Q96FL8
TCMT313	HTR2B	Serotonin 2b (5-HT2b) receptor	GPCR	P41595
TCMT314	HTR2C	Serotonin 2c (5-HT2c) receptor	GPCR	P28335
TCMT315	HTR6	Serotonin 6 (5-HT6) receptor	GPCR	P50406
TCMT318	HKDC1	Putative hexokinase HKDC1	Transferase	Q2TB90
TCMT321	MMP9	Matrix metalloproteinase 9	Hydrolase	P14780
TCMT322	MMP13	Matrix metalloproteinase 13	Hydrolase	P45452
TCMT327	TRPV1	Vanilloid receptor	Ion channel	Q8NER1
TCMT329	NQO2	Quinone reductase 2	Oxidoreductase	P16083
TCMT332	AOC3	Amine oxidase, copper containing	Oxidoreductase	Q16853
TCMT337	XPO1	Exportin-1	Unclassified	O14980
TCMT36	HTR1A	Serotonin 1a (5-HT1a) receptor	GPCR	P08908
TCMT369	IGF1R	Insulin-like growth factor I receptor	Kinase	P08069
TCMT37	HTR2A	Serotonin 2a (5-HT2a) receptor	GPCR	P28223
TCMT370	KDR	Vascular endothelial growth factor receptor 2	Kinase	P35968
TCMT374	AURKB	Serine/threonine-protein kinase Aurora-B	Kinase	Q96GD4
TCMT384	GRK6	G protein-coupled receptor kinase 6	Kinase	P43250
TCMT388	AXL	Tyrosine-protein kinase receptor UFO	Kinase	P30530
TCMT401	MET	Hepatocyte growth factor receptor	Kinase	P08581
TCMT422	CAMK2B	CaM kinase II beta	Kinase	Q13554
TCMT44	GLO1	Glyoxalase I	Lyase	Q04760
TCMT445	NEK2	Serine/threonine-protein kinase NEK2	Kinase	P51955
TCMT45	APP	Beta amyloid A4 protein	Unclassified	P05067
TCMT46	F3	Coagulation factor III	Unclassified	P13726
TCMT462	NEK6	Serine/threonine-protein kinase NEK6	Kinase	Q9HC98
TCMT47	BCL2	Apoptosis regulator Bcl-2	Ion channel	P10415
TCMT479	AKT1	Serine/threonine-protein kinase AKT	Kinase	P31749
TCMT484	PLK1	Serine/threonine-protein kinase PLK1	Kinase	P53350
TCMT508	SYK	Tyrosine-protein kinase SYK	Kinase	P43405
TCMT510	KIT	Stem cell growth factor receptor	Kinase	P10721
TCMT558	TOP2A	DNA topoisomerase II alpha	Isomerase	P11388
TCMT563	CDC25B	Dual specificity phosphatase Cdc25B	Hydrolase	P30305
TCMT565	EP300	Histone acetyltransferase p300	Transferase	Q09472
TCMT566	NOS2	Nitric oxide synthase, inducible	Oxidoreductase	P35228
TCMT567	DNMT1	DNA (cytosine-5)-methyltransferase 1	Transferase	P26358
TCMT570	ANPEP	Aminopeptidase N	Unclassified	P15144
TCMT592	XDH	Xanthine dehydrogenase	Oxidoreductase	P47989
TCMT597	SLC28A3	Solute carrier family 28 member 3	Transporter	Q9HAS3
TCMT599	UBE2N	Ubiquitin-conjugating enzyme E2 N	Transferase	P61088
TCMT608	SLC22A3	Solute carrier family 22 member 3	Transporter	O75751
TCMT613	NR3C1	Glucocorticoid receptor	Nuclear receptor	P04150
TCMT614	EGLN1	Egl nine homolog 1	Oxidoreductase	Q9GZT9
TCMT63	PPARA	Peroxisome proliferator-activated receptor alpha	Nuclear receptor	Q07869
TCMT636	POLA1	DNA polymerase alpha subunit	Transferase	P09884
TCMT645	HTR1E	Serotonin 1e (5-HT1e) receptor	GPCR	P28566
TCMT646	HTR5A	Serotonin 5a (5-HT5a) receptor	GPCR	P47898
TCMT65	HSD17B1	Estradiol 17-beta-dehydrogenase 1	Oxidoreductase	P14061
TCMT66	HSD17B2	Estradiol 17-beta-dehydrogenase 2	Oxidoreductase	P37059
TCMT689	TGM2	Protein-glutamine gamma-glutamyltransferase	Transferase	P21980
TCMT690	HDAC3	Histone deacetylase 3	Hydrolase	O15379
TCMT709	SLC28A2	Sodium/nucleoside cotransporter 2	Transporter	O43868
TCMT710	SLC28A1	Sodium/nucleoside cotransporter 1	Transporter	O00337
TCMT725	CACNA1C	Voltage-gated L-type calcium channel alpha-1C subunit	Ion channel	Q13936
TCMT726	BCR	Bcr/Abl fusion protein	Kinase	P11274
TCMT729	PIK3CA	PI3-kinase p110-alpha subunit	Transferase	P42336
TCMT730	PIK3CB	PI3-kinase p110-beta subunit	Transferase	P42338
TCMT737	APOBEC3G	DNA dC->dU-editing enzyme APOBEC-3G	Unclassified	Q9HC16
TCMT740	PIK3CG	PI3-kinase p110-gamma subunit	Transferase	P48736
TCMT751	DYRK1A	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Kinase	Q13627
TCMT752	CSNK2A1	Casein kinase II alpha	Kinase	P68400
TCMT759	SAE1	SUMO-activating enzyme subunit 1	Unclassified	Q9UBE0
TCMT783	NR3C2	Mineralocorticoid receptor	Nuclear receptor	P08235
TCMT784	AVPR2	Vasopressin V2 receptor	GPCR	P30518
TCMT785	CXCR1	Interleukin-8 receptor A	GPCR	P25024
TCMT786	CCR4	C-C chemokine receptor type 4	GPCR	P51679
TCMT791	PKN1	Protein kinase N1	Kinase	Q16512
TCMT793	PYGL	Liver glycogen phosphorylase	Transferase	P06737
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2
TCMT80	MAPK1	MAP kinase ERK2	Kinase	P28482
TCMT808	FABP5	Fatty acid binding protein epidermal	Unclassified	Q01469
TCMT809	FABP2	Fatty acid binding protein intestinal	Unclassified	P12104
TCMT810	TLR2	Toll-like receptor 2	Unclassified	O60603
TCMT815	HTR1D	Serotonin 1d (5-HT1d) receptor	GPCR	P28221
TCMT816	HTR1B	Serotonin 1b (5-HT1b) receptor	GPCR	P28222
TCMT817	HTR4	Serotonin 4 (5-HT4) receptor	GPCR	Q13639
TCMT82	ESR1	Estrogen receptor alpha	Nuclear receptor	P03372
TCMT822	FUT7	Alpha-(1,3)-fucosyltransferase 7	Transferase	Q11130
TCMT83	CD38	Lymphocyte differentiation antigen CD38	Unclassified	P28907
TCMT87	CYP2C9	Cytochrome P450 2C9	Oxidoreductase	P11712
TCMT904	PGR	Progesterone receptor	Nuclear receptor	P06401
TCMT99	SHBG	Testis-specific androgen-binding protein	Unclassified	P04278

Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID	Target Name
TCMT1170	Enterobacter cloacae
TCMT1175	Human immunodeficiency virus
TCMT1176	Streptococcus pneumoniae
TCMT1178	Actinomyces viscosus
TCMT1181	Mycobacterium tuberculosis H37Ra
TCMT1182	Streptococcus sanguinis
TCMT1183	Candida albicans SC5314
TCMT1189	Pseudomonas fluorescens
TCMT1190	Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201	Staphylococcus epidermidis ATCC 12228
TCMT1208	Escherichia coli K12
TCMT1209	Staphylococcus haemolyticus
TCMT1210	Streptococcus sobrinus
TCMT1211	Fusobacterium nucleatum
TCMT1212	Verticillium dahliae
TCMT1213	Neisseria gonorrhoeae
TCMT1215	Pseudomonas aeruginosa PAO1
TCMT1218	Staphylococcus aureus
TCMT1219	Enterococcus
TCMT1221	Human herpesvirus 4
TCMT1222	Plasmodium falciparum D6
TCMT1223	Staphylococcus epidermidis
TCMT1224	Proteus mirabilis
TCMT1226	Klebsiella pneumoniae
TCMT1229	Enterococcus faecalis
TCMT1231	Human herpesvirus 1 strain KOS
TCMT1232	Pseudomonas aeruginosa
TCMT1243	Aspergillus flavus
TCMT1245	Phytophthora cactorum
TCMT1246	Escherichia coli
TCMT1248	Hepatitis C virus
TCMT1249	Dengue virus 2
TCMT1251	Candida albicans
TCMT1253	Penicillium chrysogenum
TCMT1255	Human immunodeficiency virus 1
TCMT1257	Colletotrichum lagenarium
TCMT1282	Colletotrichum orbiculare
TCMT1286	Bacillus cereus
TCMT1294	Human parainfluenza virus 3
TCMT1296	Influenza A virus H3N2
TCMT1313	Human immunodeficiency virus 2
TCMT1314	Streptococcus viridans
TCMT1318	Human T-lymphotropic virus 1
TCMT1321	Staphylococcus hominis
TCMT1343	Staphylococcus simulans
TCMT1344	Staphylococcus sciuri
TCMT1346	Helicobacter pylori
TCMT1349	Helicobacter pylori SS1
TCMT1361	Neisseria meningitidis
TCMT1370	Prevotella melaninogenica
TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408	Colletotrichum gloeosporioides
TCMT1412	Salmonella typhimurium
TCMT1438	Plasmodium falciparum
TCMT1439	Mycobacterium smegmatis
TCMT1442	Leishmania donovani
TCMT1443	Leishmania amazonensis
TCMT1444	Fusarium oxysporum
TCMT1447	Respiratory syncytial virus
TCMT1448	Enterobacter aerogenes
TCMT1449	Influenza A virus
TCMT1450	Plasmodium falciparum 3D7
TCMT1454	Bacillus subtilis
TCMT1455	Mycobacterium tuberculosis H37Rv
TCMT1458	Filobasidiella neoformans
TCMT1462	Streptococcus mutans
TCMT1463	Mycobacterium tuberculosis
TCMT1464	Hepatitis B virus
TCMT1465	Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term	GO Name	Enriched Genes	Log10 Adjusted P-value

KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID	Enriched Genes	Log10 Adjusted P-value

Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset

Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples

Data Section	Select to Download
1. General Information of Prescription
2. Putative Targets
3. Activity & References for Filtering Putative Targets
4. GO & Pathway

TCM Prescription: Jin Tong Xiao Tincture