TCM Prescription: Yi Shen Ling Pills



Prescription Description
Prescription IDTCMF6619
Pinyin NameYi Shen Ling Wan
Chinese Name益身灵丸
English NameYi Shen Ling Pills
Function Description眩晕, 健忘, 不寐, 遗精, 阳痿
IndicationsInvoluntary ejaculation disorder, Impotence disorder, Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Dizziness, Sexual dysfunction
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SB0B [Impotence disorder (TM1), 阳痿 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ];
Human Tissues Associated with IndicationBrain, Heart, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1349 Cervus elaphus 鹿茸 TCMH1349 ABMC060-05
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH121 Biota orientalis 柏子仁 TCMH121
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 13.1335
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PPARG, TRPV1 12.9396
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, TYR 11.6743
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PPARG, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 11.6564
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, HSP90AB1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARA, PPARG, SRC, TEK, TRPV1, TYR 11.4486
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, PIM1, PPARA, PPARG, TYR, XDH 11.357
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.111
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 10.6048
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2266
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 9.88101
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 9.8485
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, TYR 9.82348
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.77157
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARG, SMAD3, SRC, TEK, XDH 9.76864
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.75247
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, NR3C1, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1 9.27084
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HSP90AB1, NR3C1, PPARG, SRC, TEK, TRPV1, TYR 9.27084
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PPARG, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.17449
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, NR3C1, PPARA, PPARG, SRC, TEK, TRPV1 9.16866
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.04493
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 9.04493
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F3, FLT3, GPR35, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.03127
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F3, FLT3, GPR35, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.01088
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 8.63175
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARG, TYR, XDH 8.51441
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR 8.19806
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, PPARG, SRC, TYR 7.68066
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.53752
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.30657
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F3, GPR35, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TRPV1 7.24262
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 7.23876
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PPARG, SMAD3, SRC, TRPV1 7.20728
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 7.15472
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA, PPARG 7.15472
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GPR35, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.04643
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, PPARA, PPARG, SMAD3, SRC, TEK, TYR 7.01787
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 6.98727
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, IGF1R, INSR, KDR, MMP2, NR3C1, PPARG, SMAD3, SRC, TRPV1 6.82362
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 6.77801
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.73487
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CDK6, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 6.7031
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.64364
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.54353
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.51399
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR 6.47028
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 6.47028
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 6.31299
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F3, FABP4, FLT3, GPR35, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.29674
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, SMAD3, SRC, TEK 6.25074
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 6.24875
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.24591
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MMP9, PIM1, PPARA, PPARG, SMAD3, SRC, TEK, TYR 6.23314
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.22056
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HMGCR, HSD11B2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, SMAD3, SRC, TEK, TRPV1, TYR 6.20912
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.16689
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.08941
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HMGCR, HSD11B2, HSP90AB1, KDR, NR3C1, PPARG, SRC, TRPV1 6.04358
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR 6.02814
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSP90AA1, HSP90AB1, INSR, MET, PPARG, SMAD3, SRC, TRPV1 6.02814
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, TRPV1 5.92942
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, SRC, TRPV1 5.88878
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, PPARG, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 5.88878
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.85458
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.78569
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.78569
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 5.73307
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, F3, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 5.72845
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PPARG, PTPN1, SMAD3, SRC, TOP2A, TRPV1 5.65862
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.64778
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.63957
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.62996
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.61572
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 5.61572
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.59076
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, XDH 5.57078
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.52725
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.51367
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.46524
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 5.38564
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, EGFR, HCAR2, HMGCR, KDR, SRC, TNKS, TNKS2, TRPV1 5.35305
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 5.3347
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PPARA, PPARG 5.31547
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.29803
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 5.29803
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.2812
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 5.27378
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.26114
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.25507
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.25507
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, SMAD3, TNKS, TOP2A 5.25507
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, XDH 5.2092
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, GBA2, HMGCR, TYR 5.19717
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, HSD11B2, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, SRC, TEK, TRPV1, TYR 5.19717
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, PPARG, SRC, TEK, TRPV1 5.09038
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, HSP90AB1, KDR, NR3C1, SRC, TRPV1 5.06841
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1, XDH 4.97225
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.89784
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS 4.89225
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, PPARG, SRC 4.86188
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.8612
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CDK6, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 4.8453
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.84058
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.80321
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, HSD11B2, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, SRC, TEK, TRPV1, TYR 4.78144
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 4.7622
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.76049
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, SRC 4.75679
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, TRPV1 4.74194
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.71333
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1, XDH 4.6564
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.63859
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, BCL2, CA2, CHRM3, CYP1B1, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PPARG, SMAD3, SRC, TEK, TRPV1 4.63859
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 4.58937
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, PPARG, SRC, TRPV1 4.57074
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 4.55693
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 4.49039
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.4874
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, HMGCR, HSP90AB1, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.39405
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, HMGCR, HSP90AB1, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.39405
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.3852
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, EGFR, GPR35, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, MMP12, MMP9, PPARA, PPARG, PTPN1, SMAD3, SRC, TRPV1 4.3839
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.34306
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PPARG, SMAD3, SRC, TNKS 4.33053
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.31237
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TRPV1, XDH 4.3063
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC, TNKS, TNKS2 4.28756
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, PTPN1, SRC, TEK, TNKS 4.25656
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS, TNKS2 4.25613
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, SRC, TNKS, TNKS2 4.24524
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.18024
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 4.13165
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PPARG, SRC, TEK 4.11528
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.10147
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARG, SMAD3, SRC, TEK 4.08652
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, SMAD3, SRC, TNKS, TOP2A 4.06728
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, TNKS 4.06728
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 4.05088
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, SMAD3, SRC, TEK, TNKS, TNKS2 4.04499
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.04499
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PPARG, SMAD3, TRPV1 4.03945
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, SRC 4.03175
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSP90AA1, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.95535
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.94704
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.94602
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, HCAR2, HSP90AB1, INSR, MMP12, PPARG, SMAD3, SRC, TRPV1 3.93208
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.91087
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PIM1, PPARA, PPARG, TYR 3.90686
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TNKS, TNKS2, TOP2A 3.86952
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.82724
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 3.80455
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 3.79414
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FLT3, HMGCR, HSP90AB1, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.79414
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.78117
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.76726
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, HSP90AB1, INSR, MMP2, MMP9, PPARG, SRC, TOP2A 3.75958
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 3.74659
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, HSP90AA1, KDR, SRC 3.74659
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.74433
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 3.7324
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PPARG, SMAD3, TEK 3.72991
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARG, SMAD3, SRC, TRPV1 3.72104
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSP90AB1, HSPA1A, MMP12, MMP2, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK 3.71307
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.69623
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.69153
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.68476
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 3.67293
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 3.66298
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.64953
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 3.64842
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSP90AB1, INSR, PPARG, SRC 3.62907
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.62395
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.61382
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PPARG, SMAD3, SRC, TNKS, TNKS2, TOP2A 3.60862
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP12, MMP2, PPARG, PTPN1, SMAD3, SRC 3.60804
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 3.59647
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, FLT3, HMGCR, INSR, KDR, PTPN1, SRC, TEK, XDH 3.59355
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTPN1, SMAD3, SRC, XDH 3.56042
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 3.56042
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.56042
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.56042
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.56042
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.55023
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.55023
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTPN1, SMAD3, SRC, XDH 3.54899
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.53455
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC 3.53455
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.53455
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 3.52749
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSP90AA1, HSP90AB1, HSPA1A, INSR, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.52749
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, TNKS 3.52352
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, PPARG, SRC, TRPV1, TYR 3.52352
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK 3.49239
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TNKS, TNKS2, TRPV1 3.49239
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.49239
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, SRC 3.49046
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, EGFR, HSPA1A 3.48417
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, HMGCR, HSP90AB1, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.47266
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PIM1, PPARA, PPARG, TYR 3.46272
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, PPARG, SRC, TEK, TRPV1 3.45354
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK, XDH 3.40829
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, PPARG, SRC, TOP2A 3.38239
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PIM1, PPARA, PPARG, TYR 3.37331
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, SRC, TEK 3.35459
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, ESR1, ESR2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.32027
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, EGFR, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PTPN1, XDH 3.31905
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSP90AB1, INSR, SRC 3.31286
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1, SRC 3.31286
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, SRC, TEK 3.31286
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.31286
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, NR3C1, SRC 3.31273
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 3.29464
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 3.27702
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.27335
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.26861
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP2A 3.24962
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.24795
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG 3.24068
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR, TYR 3.20843
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.19357
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.19193
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PPARG, SRC, TNKS, TNKS2 3.17645
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.17645
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.17645
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.13288
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.12027
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, PPARG, SRC, TRPV1 3.11857
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, PPARG, SMAD3, TEK 3.07485
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 3.06396
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, HSP90AB1 3.05507
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.04026
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PPARG, SMAD3, TEK 3.03629
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HMGCR, HSD11B2, PPARG, SRC, TRPV1, TYR 3.0333
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.00523
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.00483
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.99387
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, PPARG, SRC 2.97773
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, HCAR2, HMGCR, MMP9, PPARG, SMAD3, SRC, TOP2A, TRPV1, XDH 2.95345
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, PPARG, SMAD3, TEK, XDH 2.93783
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, HCAR2, HMGCR, MMP9, PPARG, SMAD3, SRC, TOP2A, TRPV1, XDH 2.91403
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 2.91186
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, SMAD3, TRPV1 2.89279
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.89203
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.89167
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, SRC, TEK 2.8911
[BP] GO:0051973 positive regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, TNKS 2.87373
[BP] GO:0009115 None AOX1, XDH 2.87373
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.87373
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.87373
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.87373
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, PPARG, SRC, TRPV1 2.86064
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HMGCR, IGF1R, INSR, PTPN1, SRC 2.859
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.8535
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.8535
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, KDR, MET, MMP2, MMP9, PPARG, SMAD3, SRC, TEK, TOP2A 2.85082
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSP90AB1, IGF1R, INSR, PTPN1, SRC, TEK 2.83104
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, HSP90AB1, INSR, KDR, NUAK1, PIM1, PPARA, PPARG, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 2.83
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.83
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 2.83
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9 2.83
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, HSP90AB1, MET, PPARA, SMAD3 2.82916
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PPARG 2.82261
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSP90AB1, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 2.82031
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.81292
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, PPARG, TRPV1, TYR 2.79732
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSP90AB1, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 2.76586
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 2.75467
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HMGCR, KDR, SRC, TEK 2.74487
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 2.74487
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71986
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, PPARG, SRC 2.71232
[BP] GO:0040008 regulation of growth ALOX12, APP, BCL2, CSNK2A1, EGFR, ESR2, HSPA1A, INSR, PIM1, PPARG, SMAD3, TNKS2 2.69695
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3, PPARG 2.6918
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG, TYR 2.69155
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, HMGCR, PPARA, PPARG, SMAD3, TEK 2.66925
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.66925
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, HCAR2, HMGCR, MMP9, PPARG, SMAD3, SRC, TOP2A, TRPV1, XDH 2.65429
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG 2.65209
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, SRC, TEK 2.65209
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HMGCR, HSP90AB1, INSR, KDR, PIM1, PPARG, SMAD3, SRC, TEK 2.65209
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, PPARG, SRC 2.65209
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1 2.65209
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.64736
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PPARG, SMAD3, SRC, XDH 2.64506
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.62315
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, PPARG, SRC 2.62315
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 2.62315
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.61946
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 2.5894
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.58103
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR 2.5792
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSP90AB1, IGF1R, INSR, PTPN1, SRC 2.57326
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.57326
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.57326
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.57326
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.55847
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PPARG, TEK, TRPV1, TYR 2.55504
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.54837
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, HSP90AA1, HSP90AB1, INSR, PTPN1, SRC, TEK, TNKS 2.53906
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.53906
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.53771
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.53771
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.53006
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ESR1, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.52405
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.50634
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARG, SMAD3, TEK 2.49561
[BP] GO:0046110 None AOX1, XDH 2.49067
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.49067
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, EGFR, HCAR2, HMGCR, HSP90AB1, MMP12, PTPN1, SMAD3, SRC 2.47628
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARG, PTPN1, SMAD3, SRC, XDH 2.4712
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.44372
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.44182
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, TNKS, TNKS2 2.43793
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 2.43793
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.39994
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, HMGCR, HSP90AB1, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.37603
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.37506
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HMGCR, HSP90AB1, IGF1R, INSR, PTPN1, SRC 2.37332
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, SMAD3, SRC, TRPV1 2.35018
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.34826
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PPARG, SMAD3, SRC, XDH 2.33517
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.33517
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.33517
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.33517
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.33517
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.32302
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, SRC 2.30973
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, CHRM1, EGFR, HCAR2, HSP90AB1, MMP12, SMAD3, SRC 2.30146
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.29522
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.29522
[BP] GO:0001959 None AXL, HSP90AB1, HSPA1A, MMP12, PPARG, PTPN1 2.28152
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, GPR35, HCAR2, SMAD3, TRPV1 2.27899
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.27683
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.24911
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.24911
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, EGFR, HSD11B2, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP1, MMP12, SMAD3, SRC 2.23584
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.23479
[BP] GO:0070213 None TNKS, TNKS2 2.23479
[BP] GO:0006145 None AOX1, XDH 2.23479
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23479
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.22733
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PPARG, PTPN1, SMAD3, SRC, TEK, XDH 2.22484
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.22474
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.21701
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CYP1A1, CYP1A2, EGFR, HMGCR, HSD11B2, MMP12, PPARG, SMAD3, SRC, TRPV1, TYR 2.19512
[BP] GO:0060759 None AXL, HSP90AB1, HSPA1A, MMP12, PPARG, PTPN1 2.19408
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.17347
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.17347
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.16452
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSP90AA1, HSPA1A, XDH 2.15588
[BP] GO:0032870 cellular response to hormone stimulus APEX1, EGFR, ESR1, FLT3, INSR, NR3C1, PPARG, SRC 2.15565
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.14883
[BP] GO:1901987 None APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, EGFR, HSP90AA1 2.13291
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.12275
[BP] GO:0051894 None KDR, SMAD3, TEK 2.11747
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.11747
[BP] GO:0061900 None APP, EGFR, TRPV1 2.11747
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.11747
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, PPARG 2.11007
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, PPARG 2.07138
[BP] GO:0050927 None F3, KDR, SMAD3 2.06711
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.06692
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.06692
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, SMAD3, TRPV1 2.06323
[BP] GO:0071396 cellular response to lipid AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, PPARG, SRC 2.06047
[BP] GO:0046541 None CHRM1, CHRM3 2.05405
[BP] GO:0043696 None CDK6, ESRRB 2.05405
[BP] GO:0043697 None CDK6, ESRRB 2.05405
[BP] GO:0010641 None F3, SRC 2.05405
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.05405
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.05405
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.05405
[BP] GO:0010891 None PPARA, PPARG 2.05405
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.04577
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.04511
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, HSP90AA1, HSP90AB1, HSPA1A, MMP9, TRPV1, XDH 2.0433
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.0433
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.0433
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.03894
[BP] GO:0050926 None F3, KDR, SMAD3 2.03894
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.03894
[BP] GO:1903393 None KDR, SMAD3, TEK 2.03894
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.03879
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, HSP90AB1, TEK 3.72908
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MMP2, MMP9, NR3C1, PIM1, PPARG, PTPN1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.68795
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR 3.45354
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, HSP90AA1, HSP90AB1, INSR, MET, SRC, TEK, TRPV1 3.31286
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ESR1, F3, FLT3, GBA2, GLO1, GPR35, HCAR2, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1 3.02749
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.55735
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2 2.52672
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK, TRPV1, TYR 2.50256
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.4241
[CC] GO:0031253 None ADORA1, CA4, CA9, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 2.36549
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.34315
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, F3, FLT3, GPR35, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, SRC, TEK, TRPV1 2.27136
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PPARG, SRC, TNKS2, TYR 2.17634
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR 2.11747
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SMAD3, TNKS, TYR, XDH 21.3711
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.2426
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 15.7394
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 14.9472
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3393
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1914
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PPARG, PTPN1, SMAD3, TNKS 10.0128
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 9.25291
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.01088
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PPARG, SRC, TEK, TOP2A, TRPV1 8.55325
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 8.4259
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 8.12493
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.03289
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.75592
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.88977
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.72744
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.64065
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, TEK, TRPV1 6.55934
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.24591
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.18216
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, TEK, TRPV1 6.01322
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1 5.92937
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG 5.72845
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, SRC, TEK 5.72845
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, TEK, TRPV1 5.66552
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 5.64735
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.56727
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, SMAD3, TEK, TRPV1 5.52725
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, PPARG, TRPV1 5.11665
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.09038
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 5.03309
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.00123
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 4.95857
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG 4.89225
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG 4.89225
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NR3C1 4.80141
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 4.79682
[MF] GO:0019899 enzyme binding APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, MET, NR3C1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 4.72482
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.59503
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 4.5825
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B2, HSD17B1, SRC, XDH 4.533
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.29265
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 4.24524
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PPARG, PTPN1, SMAD3 4.07467
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.91201
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, SRC, TEK, TOP2A, TRPV1, XDH 3.87764
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.72908
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, SMAD3, TOP2A, TRPV1, TYR, XDH 3.72908
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK, TRPV1 3.68927
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARG, TEK, TRPV1 3.68927
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.34804
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARG, SRC, TEK, TOP2A, TRPV1, XDH 3.33641
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.31286
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.25182
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.25182
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR, NR3C1 3.23618
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.20512
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.15369
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1, XDH 3.12027
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1, XDH 3.11857
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PPARG, PTPN1 2.98106
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87373
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.87373
[MF] GO:0003845 None HSD11B1, HSD11B2 2.87373
[MF] GO:0008389 None CYP2A13, CYP2A6 2.87373
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1 2.85082
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.80536
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1 2.73123
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, TRPV1 2.69678
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, HSP90AA1, HSP90AB1, NR3C1, PTPN1, SMAD3, SRC, TOP2A 2.66583
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.65209
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.64506
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.58803
[MF] GO:0035258 None ESR1, FLT3, PPARG, SMAD3, SRC 2.57326
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, HSP90AA1, HSP90AB1, NR3C1, PTPN1, SMAD3, SRC, TOP2A 2.53906
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.51986
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.49067
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.49067
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.49067
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.49067
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.29106
[MF] GO:0001047 None ESR1, ESR2, ESRRB, MMP12, NR3C1, PPARG 2.27136
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.23479
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.23479
[MF] GO:0051425 None APP, INSR 2.23479
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.23479
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.22474
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.22474
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.21132
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.07487
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.05405
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.05405
[MF] GO:0043559 insulin binding IGF1R, INSR 2.05405
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PPARG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.04511
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.03894
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F3, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK 2.03329


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.429
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.6949
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.6405
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.7926
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.5839
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.5839
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, SMAD3, HSP90AB1, FLT3, MMP1, MMP2, MMP9, EGFR, IGF1R, CDK6, BCL2, PPARG, MET 6.5536
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, CDK6, HSP90AB1, CHRM1, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 6.3707
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.171
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.289
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.4985
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, ADORA3, CHRM5, ADORA1, TRPV1, NR3C1 4.4782
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 4.0659
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.9481
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.5423
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.0659
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.5071
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, BCL2, EGFR, IGF1R 3.5071
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3 3.275
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 3.9642
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.0844
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.2538
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.6492
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 2.8639
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 2.7752
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.667
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2, MMP9 2.6757
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12 3.0375
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.8586
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4 2.8742
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, EGFR 2.3298
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.3978
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.3298
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, PPARA 2.1606
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12 2.232
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, PPARG, HMGCR, IGF1R 2.1036
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.0074
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2, HSPA1A 1.7289
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 1.9983
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.1414
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0074
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 1.9897
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6714
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.9809
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9205
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.6153
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, PPARG, IGF1R 1.6492
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9718
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.5127
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.3299
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 1.9281
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.2474
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.4349
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.293
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 1.856
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4224
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.251
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.3916
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.2253
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1942
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.1392
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.9739
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1717
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.8564
Huntington's disease_Homo sapiens_hsa05016 PPARG 0.244
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2503
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2619
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2501
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2619
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2698
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7354
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7219
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7138
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8035
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2952
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8035
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7219
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3025
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6851
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5892
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9825
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.71
Apoptosis_Homo sapiens_hsa04210 BCL2 0.317
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.328
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5318
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6619
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3298
Platelet activation_Homo sapiens_hsa04611 SRC 0.3469
Axon guidance_Homo sapiens_hsa04360 MET 0.3394
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.349
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3469
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9863
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9722
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 0.9792
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9382
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3752
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.0973
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9574
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3913
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3983
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3983
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3983
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.0923
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0565
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4102
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4222
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.4318
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4268
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4268
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4309
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4268
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.43
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4268
Peroxisome_Homo sapiens_hsa04146 XDH 0.4318
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.2474
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2472
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.217
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4429
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.2099
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.484
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.2472
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4859
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2318
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4989
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5011
Shigellosis_Homo sapiens_hsa05131 SRC 0.5011
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5011
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5206
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5465
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5645
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5682
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.4981
Malaria_Homo sapiens_hsa05144 MET 0.5799
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5845
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5842
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5842
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5845
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6647
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5664
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6815
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6364
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6262
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5502
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.7233
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.739
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7138
Base excision repair_Homo sapiens_hsa03410 APEX1 0.697
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7233
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8576
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7452
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9658
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.739
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8035
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8781
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9686
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.245


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)