TCM Prescription: Wu Di Yao Wine



Prescription Description
Prescription IDTCMF5331
Pinyin NameWu Di Yao Jiu
Chinese Name无敌药酒
English NameWu Di Yao Wine
Function Description风寒湿痹, 痛风, 跌打损伤
IndicationsPain, Gout
Disease ICD-11 Category MG3Z [Pain, unspecified, 疼痛,未特指的 ];
FA25 [Gout, 痛风 ];
Human Tissues Associated with IndicationSkeletalMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH611 Rubus idaeus 覆盆子 TCMH611 ITSAE336-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1133 Rosa laevigata 金樱子 TCMH1133 ITSAJ4477-14
TCMH909 Trigonella foenum -graecum 葫芦巴 TCMH909
TCMH700 Drynaria fortunei 骨碎补 TCMH700 GBVM3977-11
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH2348 Sanguis draconis 血竭 TCMH2348
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
TCMH2274 Elephas maximus 象皮 TCMH2274 GBMA14165-15
TCMH293 Manis pentadactyla 穿山甲 TCMH293 GBMA15413-17
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH456 Rhizoma dioscoreae nipponicae 地龙 TCMH456
TCMH1038 Spatholobus suberectus 鸡血藤膏 TCMH1038 ITSAK2607-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH2016 Retinervus luffae fructus 丝瓜络 TCMH2016
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPER1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 12.7976
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 12.3934
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 12.2889
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR 12.2889
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, FLT3, GPER1, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.5375
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, FLT3, GPER1, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.5131
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AR, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GPER1, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR 11.1279
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, NR3C1, PPARA, PRKCD, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TRPV1 11.107
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, INSR, NR3C1, PPARA, PRKCD, PRKCE, PTGS2, SLC6A4, SRC, TEK, TRPV1 11.0237
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT, TRPV1 10.8584
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 10.8287
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 10.8073
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC5A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 10.5104
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, FABP3, FUT7, GLO1, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 10.4925
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, EGFR, ERBB2, F10, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 10.4925
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 10.4925
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2759
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GPER1, NR3C1, PRKCE, PRKCG, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR 10.2589
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F10, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 10.0409
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, PRKCA, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.79799
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SMAD3, SRC, TRPV1 9.7066
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.65271
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.50045
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GPER1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 9.35182
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 9.23189
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 9.23189
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 9.2207
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 9.21185
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GPER1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 9.17857
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 9.11868
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4, NQO2, PTGS1, RORC 8.85259
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, GPER1, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.84989
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 8.52242
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.49438
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F10, FABP4, FLT3, GPER1, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.28912
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 8.25422
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 8.24032
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 8.17778
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, NR3C1, PRKCE, PTGS2, RORC, SLC6A4, SRC, TYR 8.03401
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 8.02491
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, GPER1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.0232
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, GPER1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.0232
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.01529
[BP] GO:0015872 None CHRM5, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 7.98362
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.9669
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CYP19A1, EGFR, ERBB2, GPER1, GPR35, HCAR2, HSPA1A, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TRPV1 7.83351
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CHRM1, CYP19A1, CYP1B1, EGFR, ERBB2, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.82935
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.80446
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.78988
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.77126
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, EGFR, ESR1, GPER1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SLC6A4, SRC, TRPV1 7.74384
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TOP2A, TRPV1 7.65581
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, GPER1, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SLC5A1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR 7.65101
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.57666
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.5619
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, GPER1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR 7.54642
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, GPER1, HCAR2, HSD11B1, HSD17B1, HSD17B2, PRKCA, PRKCE, SLC22A1 7.50394
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.49609
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, FLT3, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.49609
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, ADRB1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GPR35, INSR, KCNH2, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, SRC, TERT, TRPV1 7.42934
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, CHRM5, DUSP3, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.42242
[BP] GO:0051937 None CHRM5, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 7.39079
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.38768
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRB1, ALOX15, APP, AR, BCL2, CDC25B, CHRM5, DUSP3, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.35335
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, FLT3, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 7.3505
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC, TERT 7.34989
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1 7.29974
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.22817
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 7.22716
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, APP, AR, EGFR, ERBB2, ESR1, FLT3, GPER1, IGF1R, INSR, MMP2, NR3C1, PRKCD, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TRPV1 7.05405
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CES1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TYR 7.04211
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, GPER1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.03538
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, PGR, PIM1, PPARA, RORC, SRC 7.01314
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, EGFR, F10, GPER1, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT 7.0107
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRB1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 6.86519
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.80023
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 6.76439
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, FLT3, GPER1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.73551
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, AR, EGFR, ERBB2, FLT3, GPER1, INSR, KDR, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 6.73476
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, APP, AR, DUSP3, EGFR, ERBB2, FLT3, GPER1, IGF1R, INSR, KDR, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 6.72678
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRB1, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, GPER1, GPR35, HCAR2, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.68456
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, EGFR, ERBB2, GPER1, HCAR2, INSR, KCNH2, MMP12, PRKCD, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TERT, TRPV1 6.59699
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, BCL2, CDC25B, CHRM1, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, GPER1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK, TERT 6.58545
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 6.51367
[BP] GO:0015844 None CHRM5, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 6.50726
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.50726
[BP] GO:0003018 None ADORA1, ADRA2A, ADRB1, CHRM1, CHRM3, EGFR, GPER1, PTGS2, SLC6A4, SRC, TEK 6.50631
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRB1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 6.41781
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, PPARA, PTGS1, PTGS2 6.33688
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 6.32362
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRB1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 6.31433
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 6.27208
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CHRM5, CYP1A1, FABP3, FLT3, GPER1, HCAR2, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 6.27134
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 6.234
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 6.21546
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 6.20631
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, GPER1, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.20371
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, GPER1, GPR35, INSR, KCNH2, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 6.1112
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.07489
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 6.069
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM5, FABP3, KCNH2, PPARA, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, TRPV1 6.05747
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, ESRRB, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 5.97748
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, PIK3CB, PIM1, PRKCD, SRC, TEK, TYR 5.9359
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR, GPER1, GPR35, HCAR2, KCNH2, PRKCA, PTGS2, SMAD3, TRPV1 5.88409
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KCNH2, KDR, NR3C1, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 5.87182
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 5.84754
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KCNH2, KDR, NR3C1, PRKCD, PRKCE, PTGS2, SRC, TRPV1 5.81136
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 5.7848
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, XDH 5.77021
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.77021
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.70077
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 5.66583
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 5.65545
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.65545
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6, CYP3A4 5.65545
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, HCAR2, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 5.65545
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CACNA1C, EGFR, GPER1, HCAR2, KDR, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 5.63984
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, AR, BCL2, DUSP3, EGFR, ERBB2, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.6014
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GPER1, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 5.5932
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, AR, BCL2, DUSP3, EGFR, ERBB2, ESR1, ESR2, GPER1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.5792
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.56792
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPER1, GPR35, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 5.55379
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GPER1, INSR, PTGS2, SLC22A2, SLC22A3, SLC6A2, SLC6A4, SMAD3, TRPV1 5.38339
[BP] GO:0003013 None ADORA1, ADRA2A, ADRB1, CHRM1, CHRM3, EGFR, GPER1, PTGS2, SLC6A4, SRC, TEK 5.38078
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 5.37273
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 5.37273
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, GPER1, INSR, PRKCA, PRKCE, SLC6A4, SRC, TERT 5.35665
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.33124
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.33124
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.3091
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 5.29718
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRB1, APP, AR, AXL, BCL2, CA2, CHRM3, CYP1B1, EGFR, ESRRB, GPER1, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1 5.27057
[BP] GO:0097746 None ADORA1, ADRA2A, ADRB1, CHRM1, CHRM3, EGFR, GPER1, PTGS2, SLC6A4 5.25426
[BP] GO:0035296 None ADORA1, ADRA2A, ADRB1, CHRM1, CHRM3, EGFR, GPER1, PTGS2, SLC6A4 5.25426
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, GPER1, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 5.16624
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, DUSP3, EGFR, ESR1, FABP4, GPER1, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.11541
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 5.10271
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 5.08727
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 5.07095
[BP] GO:0050880 None ADORA1, ADRA2A, ADRB1, CHRM1, CHRM3, EGFR, GPER1, PTGS2, SLC6A4 5.03499
[BP] GO:0035150 None ADORA1, ADRA2A, ADRB1, CHRM1, CHRM3, EGFR, GPER1, PTGS2, SLC6A4 5.00893
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, AR, BCL2, CYP19A1, DUSP3, EGFR, ERBB2, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.98722
[BP] GO:0006940 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, GPER1, PTGS2 4.93999
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PGR, PPARA, PRKCG, RORC, SLC6A4, SRC, TOP2A 4.92345
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 4.91993
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, FLT3, GPER1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 4.91783
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 4.89832
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, GPER1, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 4.87976
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GPER1, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 4.84171
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 4.83583
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, GPER1, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.82903
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, ADRB1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, ESR1, ESR2, FABP4, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.79138
[BP] GO:0001775 cell activation ADRA2A, ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 4.77978
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 4.77763
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ERBB2, ESR1, FLT3, GPER1, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.75975
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, F10, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 4.75048
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, ADRB1, APP, AR, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, FLT3, GPER1, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.73094
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRB1, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.71434
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR 4.65964
[BP] GO:0015893 None CA2, CHRM5, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4 4.6596
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.64059
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.63636
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.63636
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, CACNA1C, CHRM1, EGFR, ERBB2, GPER1, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 4.61884
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, ADRB1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPER1, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.52029
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 4.46281
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GPER1, GPR35, KCNH2, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.46027
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, NR3C1, PGR, SRC 4.44843
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 4.41905
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PGR, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.41435
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, GPER1, KDR, PRKCE, SRC, TRPV1 4.41435
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 4.3821
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, ALDH2, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, HSPA1A 4.36707
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, APP, AR, BCL2, CACNA1C, CHRM1, CSNK2A1, EGFR, ERBB2, GPER1, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 4.32733
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CACNA1C, CHRM1, GPER1, GPR35, KCNH2, MMP9, PRKCD, PRKCE, PTGS2, SLC6A4 4.31561
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19, CYP3A4 4.30129
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, GPER1, IGF1R, INSR, MMP2, PRKCD, PTGS2, SLC6A4, SRC, TRPV1 4.29261
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, GPER1, PRKCE, PTGS2 4.28688
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 4.27866
[BP] GO:0010676 None ESRRB, GPER1, INSR, PPARA, PRKCE, SRC 4.27834
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA, PRKCD, PRKCE 4.27834
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, EGFR, ERBB2, GPER1, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 4.26945
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, ERBB2, GPER1, KDR, PRKCA, PTPN1, SRC, TEK 4.24826
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 4.24341
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, GPER1, NR3C1, PTGS2, SRC 4.23729
[BP] GO:0015696 None CHRM5, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 4.23729
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CES1, CYP1A1, CYP1B1, KDR, PRKCD, PRKCE, SLC6A4, SRC 4.2268
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 4.22659
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, EGFR 4.20064
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 4.20064
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DUSP3, EGFR, ERBB2, FLT3, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 4.18944
[BP] GO:0015874 None SLC22A1, SLC22A2, SLC6A2 4.16985
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.16985
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, APEX1, AR, EGFR, ESR1, FLT3, GPER1, INSR, NR3C1, PRKCD, PRKCE, SRC 4.15945
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.15945
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.13786
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR, KCNH2, PTGS2 4.10817
[BP] GO:0090257 None ADORA1, ADRA2A, CACNA1C, CHRM1, CHRM2, CHRM3, GPER1, PRKCA, PTGS2, SMAD3 4.10354
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 4.08652
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 4.08652
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, GPER1, GPR35, KCNH2, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.05969
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, ERBB2, PPARA, SMAD3 4.04855
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, AR, BCL2, DUSP3, EGFR, ERBB2, ESR1, ESR2, GPER1, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 3.98462
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 3.97017
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, GPER1, IGF1R, INSR, MMP2, PRKCD, PTGS2, SLC6A4, SRC, TRPV1 3.96353
[BP] GO:0070201 None ACHE, ADRA2A, APP, BCL2, CACNA1C, CHRM1, EGFR, ERBB2, GPER1, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.9471
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.91937
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, APP, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 3.8761
[BP] GO:0090066 None ADORA1, ADRA2A, ADRB1, ALOX15, CHRM1, CHRM3, EGFR, GPER1, PRKCD, PRKCE, PTGS2, SLC6A4 3.86086
[BP] GO:0051234 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, EGFR, F10, FABP3, HSPA1A, KCNH2, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 3.85849
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, GPR35, KCNH2, MMP9, PRKCE, PTGS2 3.85269
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, ERBB2, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 3.85146
[BP] GO:1901184 None ADORA1, ADRA2A, APP, EGFR, ERBB2, GPER1, MMP9 3.83551
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, CHRM1, EGFR, ERBB2, GPER1, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.83141
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 3.82566
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, FLT3, GPER1, HSPA1A, INSR, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.80274
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA, TERT 3.7949
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.79249
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, ERBB2, ESR1, ESRRA, GPER1, HCAR2, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC 3.79249
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.72233
[BP] GO:1903827 regulation of cellular protein localization APP, AR, BCL2, CHRM1, CSNK2A1, EGFR, ERBB2, GPER1, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 3.70463
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2, TERT 3.68687
[BP] GO:0045913 None ESRRB, GPER1, INSR, PPARA, PRKCE, SRC 3.66849
[BP] GO:0051223 None ACHE, ADRA2A, APP, CACNA1C, CHRM1, EGFR, ERBB2, GPER1, HCAR2, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.64308
[BP] GO:0038128 None EGFR, ERBB2, PIK3CA, PRKCA, SRC 3.63898
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 3.63474
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3, SLC6A4 3.62815
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.62504
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 3.61646
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 3.61646
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.61638
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, PRKCG, SMAD3 3.61589
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GPER1, NR3C1, PTGS2, SRC 3.58579
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, GPER1, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SLC6A4, SMAD3, SRC, TERT, TOP2A 3.57311
[BP] GO:0007188 None ADORA1, ADRA2A, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, GPER1 3.56947
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, EGFR, ESR1, GPER1, GPR35, KCNH2, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.55593
[BP] GO:1903829 positive regulation of cellular protein localization APP, BCL2, CHRM1, EGFR, ERBB2, GPER1, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TERT 3.55593
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.55593
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.55593
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, PRKCD, SRC, TEK 3.55392
[BP] GO:0003008 None ADORA1, ADRA2A, ADRB1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, EGFR, GPER1, INSR, KCNH2, PIK3CA, PRKCG, PTGS2, SLC5A1, SLC6A4, SRC, TEK, TRPV1, TYR 3.49097
[BP] GO:0071383 None AR, EGFR, FLT3, GPER1, NR3C1, SRC 3.48823
[BP] GO:0006937 None ADORA1, ADRA2A, CACNA1C, CHRM1, CHRM2, CHRM3, GPER1, PTGS2 3.48519
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2A6, CYP2C19, CYP2D6, CYP3A4 3.48519
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.48519
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, CHRM1, EGFR, ERBB2, GPER1, HCAR2, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.48475
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.46408
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GPER1, PPARA, PRKCD, SMAD3, TEK 3.46408
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT 3.43666
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, ALDH2, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.43666
[BP] GO:0043434 None APEX1, FABP3, GPER1, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 3.43666
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 3.43666
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.43666
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALDH2, ALOX15, APP, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR 3.42742
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.42447
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, EGFR, ESR1, GPER1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.39248
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APEX1, APP, AR, AURKB, BCL2, CSNK2A1, CYP2D6, DUSP3, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 3.39248
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.37516
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.36537
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.36537
[BP] GO:0051179 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, EGFR, ESR1, F10, FABP3, HSPA1A, KCNH2, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 3.36333
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TERT, TOP2A 3.3484
[BP] GO:0010675 None ESRRB, GPER1, INSR, PPARA, PRKCE, RORC, SRC 3.3454
[BP] GO:0006810 None ACHE, ADORA1, ADRA2A, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, F10, FABP3, HSPA1A, KCNH2, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SRC, TRPV1, XDH 3.34379
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, GPER1, MMP12, PPARA, PRKCD, SMAD3, TEK 3.32702
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, ESR1, FLT3, GPER1, NR3C1, PRKCE, RORC, SLC6A4, SRC 3.30983
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.30328
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, PRKCE, SRC 3.30115
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, GPER1, PTGS2, SLC6A4 3.28286
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, PRKCD, PRKCE, PTPN1, SRC 3.26561
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, GPER1, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 3.26091
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.25444
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.25444
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.25444
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.24459
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, PRKCE, SRC 3.21555
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, GPER1, MMP2, MMP9, PTGS2, TERT 3.20459
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, GPER1, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.20087
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.19146
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.18816
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PGR, PTGS2, SRC 3.18675
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, GPER1, PRKCE, PTGS2, SLC6A4 3.18602
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, GPER1, PRKCE, PTGS2, SLC6A4 3.18602
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, GPER1, MMP9 3.17717
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC, TERT 3.17598
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, SLC6A4, TEK, TRPV1, TYR 3.17598
[BP] GO:0007200 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, ESR1 3.15287
[BP] GO:0007154 None ADORA1, ADRB1, AR, AXL, BCL2, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, PGR, PRKCG, PTGS2, SLC6A2, TEK, TRPV1 3.14992
[BP] GO:0007187 None ADORA1, ADRA2A, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, GPER1 3.14923
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.13732
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 3.13548
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.12396
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, KDR, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 3.11972
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, ERBB2, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.09926
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, ESR1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK 3.08678
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, APP, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.08235
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, GPER1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.08163
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GPER1, HSPA1A, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT 3.08163
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.0768
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, AR, BCL2, CACNA1C, CHRM1, CSNK2A1, EGFR, ERBB2, GPER1, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TERT 3.07533
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, GPER1, HCAR2, MMP12, PRKCE, SLC6A4, SRC, TRPV1 3.07443
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CYP1B1, ERBB2, FABP3, GPER1, HSPA1A, PTGS2, SLC6A4, SMAD3, TERT, XDH 3.07353
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, PPARA, PRKCD, PTGS2, SMAD3, TEK 3.01724
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.01291
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.01268
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.00642
[BP] GO:0055065 metal ion homeostasis APP, BCL2, CACNA1C, EGFR, ESR1, GPER1, GPR35, KCNH2, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.00136
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, EGFR, ERBB2, FLT3, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 2.97746
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, GPER1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.97243
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SLC6A4, SRC 2.97109
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.96497
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 2.95666
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 2.9536
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, GPER1, KDR, PRKCA, SRC, TEK 2.94996
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, ESR1, GPER1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.92832
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, F10, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.90936
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTGS2, SLC6A4, TEK, TRPV1, TYR 2.88869
[BP] GO:0050678 None AR, EGFR, ERBB2, KDR, MMP12, PGR, PRKCA, SMAD3, TEK, XDH 2.88851
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.88746
[BP] GO:0046883 regulation of hormone secretion ADORA1, ADRA2A, CACNA1C, CYP19A1, EGFR, GPER1, HCAR2, PRKCA, PRKCE 2.88746
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, APP, AURKB, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 2.88218
[BP] GO:1901342 regulation of vasculature development CYP1B1, ERBB2, GPER1, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT, XDH 2.88218
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, EGFR, ERBB2, FLT3, INSR, PIK3CB, PTPN1, SRC 2.87872
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.85908
[BP] GO:0019229 None ADRA2A, CHRM1, CHRM3, EGFR, PTGS2 2.85905
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.85905
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 2.85195
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPER1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.84649
[BP] GO:0008217 None ADORA1, ADRB1, AR, PPARA, PTGS1, PTGS2, SMAD3 2.84649
[BP] GO:0040008 regulation of growth ADRB1, APP, AR, BCL2, CSNK2A1, EGFR, ERBB2, ESR2, HSPA1A, INSR, PIK3CA, PIM1, SLC6A4, SMAD3 2.83776
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPER1, GPR35, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.83776
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 2.8312
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.82936
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GPER1, IGF1R, INSR, PRKCD, SRC 2.80494
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, IGF1R, PIK3CA, PIK3CB 2.80396
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.80396
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.80396
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.79755
[BP] GO:0051172 None ADRA2A, APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.79741
[BP] GO:1905475 None AR, BCL2, CSNK2A1, EGFR, ERBB2, GPER1, PRKCE 2.78584
[BP] GO:0035408 None PRKCA, PRKCB 2.77562
[BP] GO:0009115 None AOX1, XDH 2.77562
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TEK, TERT 2.77562
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.77562
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, PRKCE 2.76207
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPER1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.76106
[BP] GO:0006855 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.75049
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, PGR, PTGS2, SLC6A4, SRC, TOP2A 2.75041
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9, TRPV1 2.74187
[BP] GO:0070848 response to growth factor APP, EGFR, ERBB2, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.72545
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DUSP3, EGFR, ERBB2, FLT3, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 2.72545
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 2.72545
[BP] GO:0022600 None ADRA2A, CHRM1, CHRM3, CHRM5, SLC5A1 2.72356
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.71665
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.71514
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.70536
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.70536
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.69805
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CES1, CYP1A1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PGR, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A 2.68566
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.66828
[BP] GO:0022900 electron transport chain AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.65359
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, EGFR, ERBB2, FLT3, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 2.6504
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, EGFR, ERBB2, FLT3, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.64743
[BP] GO:0031329 regulation of cellular catabolic process ADRA2A, APEX1, BCL2, ESRRB, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.60668
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.60456
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.60456
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPER1, GPR35, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.5912
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, GPER1, HCAR2, PIK3CB, PTGS2 2.5912
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GPER1, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.58566
[BP] GO:0023052 None ADORA1, ADRB1, AR, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, KCNH2, PGR, PRKCG, SLC6A2, TEK 2.5738
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRB1, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.56287
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TRPV1 2.56263
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 2.56
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, GPER1, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.55079
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.55079
[BP] GO:0045742 None ADORA1, ADRA2A, GPER1, MMP9 2.54627
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.54627
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.54075
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, GPER1, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK 2.54075
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.51896
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, MET, PIK3CA, TRPV1 2.51872
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.51453
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, CACNA1C, EGFR, GPER1, HCAR2, MMP12, PRKCA, PRKCE, SRC 2.51017
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.50704
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, GPER1, INSR, PPARA, PRKCE, RORC, SRC 2.48909
[BP] GO:0050679 None AR, EGFR, ERBB2, KDR, MMP12, PRKCA, TEK 2.47519
[BP] GO:1901186 None ADORA1, ADRA2A, GPER1, MMP9 2.46901
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation GPER1, MMP2, MMP9, TERT 2.46901
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, MMP12, PPARA, PRKCB, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, TRPV1 2.45407
[BP] GO:0050793 regulation of developmental process ADRB1, APP, AR, AXL, BCL2, CA2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, GPER1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.43848
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.43325
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.43325
[BP] GO:0042060 None ALOX15, EGFR, ERBB2, PPARA, SMAD3 2.41896
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.39806
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.39392
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, EGFR, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.387
[BP] GO:0006812 None CACNA1C, CHRM5, KCNH2, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, TRPV1 2.37874
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CACNA1C, CYP19A1, EGFR, GPER1, HCAR2, MMP12, PRKCA, PRKCE, SLC6A4, SRC, TRPV1 2.37874
[BP] GO:0060748 None AR, PGR 2.37874
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.37874
[BP] GO:0046110 None AOX1, XDH 2.37874
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.37874
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.37874
[BP] GO:0002520 None CACNA1C, SMAD3 2.37874
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.37478
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.37478
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.37478
[BP] GO:0070920 None EGFR, ESR1, TERT 2.37478
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.37478
[BP] GO:1903076 None AR, CSNK2A1, EGFR, GPER1, PRKCE 2.3632
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, TERT, XDH 2.34819
[BP] GO:0015850 None CHRM5, SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 2.34494
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.342
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.3179
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.31789
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.31789
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, GPER1, GPR35, KCNH2, KDR, SRC, TRPV1 2.31365
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.30436
[BP] GO:0001504 None SLC22A3, SLC6A2, SLC6A4 2.30436
[BP] GO:0038127 None EGFR, ERBB2, PIK3CA, PRKCA, SRC 2.30009
[BP] GO:1904063 None ADRA2A, GPR35, KCNH2, MMP9, PRKCE 2.30009
[BP] GO:0002793 None ACHE, ADORA1, EGFR, GPER1, HCAR2, MMP12, PRKCE, SRC 2.29595
[BP] GO:0051254 None APP, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.29299
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, CACNA1C, ESR1, GPER1, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.29299
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.2892
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.2892
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 2.2892
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, GPER1, HCAR2, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.2892
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.28405
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, PTGS2, SLC6A4, TRPV1, TYR 2.26247
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.26205
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.26205
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, SLC22A2, SLC6A4 2.239
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, APP, BCL2, GPR35, HSPA1A, KCNH2, MMP9, PRKCB, PRKCE, PTGS2 2.21808
[BP] GO:1904375 None AR, CSNK2A1, EGFR, GPER1, PRKCE 2.1948
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, NR3C1, PTGS2 2.19464
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.19463
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.19463
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.17514
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CACNA1C, CYP19A1, EGFR, GPER1, HCAR2, MMP12, PRKCA, PRKCE, SLC6A4, SRC 2.16799
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.14765
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.14765
[BP] GO:0045893 None APP, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.14505
[BP] GO:1903508 None APP, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.14505
[BP] GO:2000351 None GPER1, KDR, TEK, TERT 2.14505
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.14505
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.14472
[BP] GO:1902680 None APP, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, INSR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.14372
[BP] GO:0050708 None ACHE, ADRA2A, CACNA1C, EGFR, GPER1, HCAR2, MMP12, PRKCA, PRKCE, SRC 2.14307
[BP] GO:0050890 None ADORA1, APP, CHRM1, EGFR, INSR, PRKCG, PTGS2, SLC6A4 2.13417
[BP] GO:1901374 None SLC22A1, SLC22A2 2.13417
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.13417
[BP] GO:0006145 None AOX1, XDH 2.13417
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.13417
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, PRKCE, SRC, TRPV1 2.13265
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, GPER1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.13193
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, INSR, PRKCE, TERT 2.12114
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, GPER1, MMP9, PTGS2, SMAD3, SRC, XDH 2.11954
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, EGFR, ERBB2, FLT3, INSR, PIK3CB, PTPN1, SRC 2.09828
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.09174
[BP] GO:0034766 None ADRA2A, GPR35, KCNH2, MMP9, PRKCE 2.08847
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, GPER1, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 2.06985
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.06773
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.06773
[BP] GO:0010959 None ADORA1, ADRA2A, BCL2, CACNA1C, GPER1, GPR35, KCNH2, PRKCE, PTGS2 2.06773
[BP] GO:0048731 system development ACHE, ADORA1, ALPL, CACNA1C, CHRM1, CHRM2, CHRM3, ERBB2, MMP9, PIK3CA, SMAD3, SRC, TEK 2.06773
[BP] GO:1903532 None ACHE, CYP19A1, EGFR, GPER1, HCAR2, MMP12, PRKCE, SLC6A4, SRC 2.05999
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.05217
[BP] GO:0034762 None ADRA2A, APP, BCL2, CA2, CACNA1C, GPER1, GPR35, KCNH2, MMP9, PRKCE 2.04379
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC 2.04094
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, GPER1, KDR, TEK 2.03331
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, PRKCD, PTGS2, SMAD3 2.01848
[BP] GO:0042752 None ADORA1, PPARA, PRKCG, RORC, TOP2A 2.01848
[BP] GO:0035428 None SLC5A1, SLC5A2, SLC5A4 2.01848
[BP] GO:1904659 None SLC5A1, SLC5A2, SLC5A4 2.01848
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.01848
[BP] GO:1905950 None SLC5A1, SLC5A2, SLC5A4 2.01848
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.01848
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.01848
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.01848
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.01585
[BP] GO:0033555 multicellular organismal response to stress ADRB1, BCL2, PRKCG, SLC6A2 2.01585
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.01585
[BP] GO:1904062 None ADRA2A, APP, CACNA1C, GPER1, GPR35, KCNH2, MMP9, PRKCE 2.007
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.00384
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.00384
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ERBB2, ESR1, F10, FLT3, GLO1, GPER1, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 8.24032
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, GLO1, GPER1, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 6.78653
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRB1, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, F10, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, SLC22A1, SLC22A2, SLC22A3, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, TEK, TRPV1 6.19659
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ADRB1, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, DUSP3, EGFR, ERBB2, F10, FLT3, GPER1, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PRKCG, PTGS2, SLC22A1, SLC22A2, SLC22A3, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SRC, TEK, TRPV1 6.02535
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRB1, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GPER1, GPR35, IGF1R, INSR, KDR, MET, SLC22A1, SLC22A2, SLC22A3, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, TEK, TRPV1 5.43723
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, F10, FLT3, FUT7, GPER1, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, NR3C2, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SRC, TEK, TRPV1, TYR 5.03664
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, CHRM3, EGFR, ERBB2, SLC22A1, TEK 4.8225
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, GPER1, INSR, MET, PRKCG, PTGS2, SLC22A1, SRC, TEK, TRPV1 4.09334
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, ERBB2, GPER1, HSPA1A, KCNH2, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TYR 4.02779
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, F10, FLT3, GPER1, HSD11B1, HSD17B2, NR3C2, PTGS1, PTGS2, PTPN1 3.94765
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GPER1, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 3.76779
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APEX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TOP2A, TRPV1, TYR, XDH 3.69376
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, GPER1, SLC22A2, SLC6A4 3.40642
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, GPER1, HSD11B1, HSD17B2, NR3C2, PTGS1, PTGS2 2.88218
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, GPER1, PRKCG, SLC22A2, SLC6A4, SRC, TRPV1 2.59109
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.58429
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.56337
[CC] GO:0032589 None ADORA1, GPER1, INSR, TRPV1 2.39033
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CACNA1C, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.38085
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.07309
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TYR, XDH 23.3574
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.0015
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 13.6078
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, F10, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TOP2A, TYR, XDH 12.6602
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3 12.2329
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 11.7565
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, NR3C1, NR3C2, PGR, RORC, SHBG 11.3259
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 11.107
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, RORC 10.4925
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC6A4, SRC, TEK, TOP2A, TRPV1 10.4752
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.42176
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 9.42176
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.35265
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 9.11868
[MF] GO:0042562 hormone binding ACHE, AR, CHRM3, EGFR, GPER1, HSD17B1, IGF1R, INSR, NQO2, NR3C1, SHBG 8.9205
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRB1, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, TRPV1 8.49797
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PGR, PPARA, RORC 8.38949
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PGR, PPARA, RORC 8.38949
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, XDH 8.38949
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 8.31868
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 8.01101
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 7.92135
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 7.8566
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 7.59548
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRB1, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PRKCE, RORC, SMAD3, TEK, TRPV1 7.5619
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 7.52352
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRB1, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, TRPV1 7.39079
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.36357
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, CYP3A4 7.35161
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, TYR 7.32919
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRB1, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK, TRPV1 7.09311
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 6.80613
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 6.78653
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.78608
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, TEK 6.78608
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4 6.76013
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, GPER1, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC, SHBG, TRPV1 6.4179
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.32362
[MF] GO:0048037 cofactor binding ALDH2, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 6.2961
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.16797
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.07489
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 5.87648
[MF] GO:0019899 enzyme binding ADRA2A, ADRB1, APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRB, HSPA1A, KCNH2, MET, NR3C1, PGR, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TOP2A 5.67932
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TERT 5.62442
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.47998
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, INSR, KDR 4.83137
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ADRB1, ALDH2, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SHBG, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.83114
[MF] GO:0005333 None SLC22A1, SLC22A2, SLC6A2 4.70049
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, APP, BCL2, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PGR, PTGS2, SLC22A1, SLC6A4, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 4.28727
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.16985
[MF] GO:0008519 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 4.16147
[MF] GO:0008227 None ADRA2A, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5 4.07785
[MF] GO:0015238 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC6A2, SLC6A4 3.97017
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 3.95973
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 3.82298
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.62815
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.61638
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 3.57975
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.56947
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.56379
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 3.50795
[MF] GO:1901363 heterocyclic compound binding ADORA1, ALDH2, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.44427
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.42663
[MF] GO:0016903 None AKR1B1, AKR1B10, ALDH2, AOX1, XDH 3.42663
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.38569
[MF] GO:1901618 None SLC22A1, SLC22A2, SLC22A3, SLC6A2, SLC6A4 3.38532
[MF] GO:0000166 nucleotide binding ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 3.21797
[MF] GO:1901265 nucleoside phosphate binding ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 3.21665
[MF] GO:0036094 small molecule binding ADORA1, ALDH2, AOX1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 3.20243
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 3.18602
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, FLT3, GPER1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK, TRPV1 3.18602
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA2A, ADRB1, AKR1B1, AKR1B10, ALDH2, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, DUSP3, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPER1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SHBG, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 3.18429
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, ADRB1, AOX1, AR, AXL, BCL2, EGFR, ERBB2, FLT3, KCNH2, NQO2, PTGS2, SLC22A1, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 3.16572
[MF] GO:0015291 None SLC22A1, SLC22A2, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4 3.13732
[MF] GO:0015370 None SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4 3.05519
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.05226
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.05226
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 2.85195
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 2.80494
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.80396
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.77562
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.77562
[MF] GO:0008389 None CYP2A13, CYP2A6 2.77562
[MF] GO:0035403 None PRKCA, PRKCB 2.77562
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.70536
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.69805
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA, PTPN1, SMAD3 2.62256
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.61117
[MF] GO:0022804 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4 2.55886
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, FLT3, KCNH2, NQO2, PTGS2, SLC22A1, SLC6A4, SMAD3, TERT, TOP2A, TYR, XDH 2.55745
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.50704
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 2.50426
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 2.50361
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, ERBB2, MET, PIK3CA, PIK3CB 2.49205
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, F10, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 2.47629
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, INSR, KDR, SMAD3 2.45048
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.37874
[MF] GO:0015307 None SLC47A1, SLC47A2 2.37874
[MF] GO:1901375 None SLC22A1, SLC22A2 2.37874
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.37874
[MF] GO:0005330 None SLC6A2, SLC6A4 2.37874
[MF] GO:0005277 None SLC22A1, SLC22A2 2.37874
[MF] GO:0008513 None SLC22A1, SLC22A2 2.37874
[MF] GO:0004699 None PRKCD, PRKCE 2.37874
[MF] GO:0047374 None CES1, CES2 2.37874
[MF] GO:0019838 growth factor binding EGFR, ERBB2, IGF1R, INSR, KDR, TEK 2.32809
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.306
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.30436
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.30436
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.30436
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, NR3C1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.29595
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.2892
[MF] GO:0008324 None CACNA1C, KCNH2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLC6A2, SLC6A4, TRPV1 2.2892
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, NR3C1, PRKCB, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.25153
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.1948
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.19464
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, ESRRB, FLT3, PIM1, PPARA, PRKCB, SMAD3, SRC, TERT 2.17568
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.16151
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 2.15266
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.14063
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.13417
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.13417
[MF] GO:0032795 None ADORA1, ADRA2A 2.13417
[MF] GO:0005497 None AR, SHBG 2.13417
[MF] GO:0051425 None APP, INSR 2.13417
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.13417
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.12634
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.06773
[MF] GO:0015149 None SLC5A1, SLC5A2, SLC5A4 2.01848
[MF] GO:0005326 None SLC22A1, SLC22A2, SLC6A2, SLC6A4 2.01585


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.1124
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, CHRM3, CHRM1, PIK3CA, PRKCB, CHRM5, BCL2, PRKCA, CACNA1C, PIK3CB 10.0024
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, PRKCB, CYP2D6, ALOX5, ALOX15, PRKCA, CACNA1C, PTGS2, CYP2C19, PTGS1, SLC6A4 10.0024
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, ERBB2, KDR, MET 9.5319
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.5319
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, GPER1, PRKCD, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 9.5319
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, AR, PIK3CA, ERBB2, BCL2, MET 8.7247
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, ERBB2, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 9.4077
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB 8.289
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4, CYP2C19 9.1067
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 8.2879
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R 8.2714
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, PIK3CA, ERBB2, BCL2, PIM1, CYP1B1, MET 7.769
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, ERBB2, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 7.7185
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, ADRB1, PIK3CB, PTGS2, PTGS1 7.8827
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PIK3CA, PRKCB, SRC, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 7.5781
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.6927
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, PRKCA, PIK3CB, TRPV1 7.3887
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, CHRM3, CHRM1, PRKCB, CHRM5, ERBB2, PRKCA, ADRB1, CACNA1C, EGFR 7.2904
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 7.2931
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.7886
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 6.3221
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 6.6718
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, ERBB2, PRKCA, PIK3CB, EGFR 6.6153
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB, NR3C2 7.6809
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PIK3CA, PRKCB, ERBB2, PRKCA, PIK3CB, EGFR 6.6617
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 6.0346
Glioma_Homo sapiens_hsa05214 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 6.2537
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, CYP3A4, CYP2C19, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALDH2, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 5.6925
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, CACNA1C, PIK3CB, PTGS2, EGFR 5.7765
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 5.9263
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, INSR, KDR, BCL2, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 5.5656
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PRKCE, ADORA1, ADRB1, CACNA1C, PIK3CB, ADRA2A 5.6071
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, ADORA3, CHRM5, ADORA1, ADRB1, TRPV1, NR3C1, ADRA2A 5.5827
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, ERBB2, BCL2, PIK3CB, EGFR, IGF1R 5.4433
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, CACNA1C, EGFR 5.389
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PIK3CA, ADORA1, ADRB1, CACNA1C, PIK3CB, PPARA 5.0633
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.336
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.1406
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 4.7219
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, CACNA1C, PIK3CB 5.7765
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.7219
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR 3.9855
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.2809
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, ERBB2, PIK3CB, MET, EGFR 5.0325
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, CYP2C19, PTGS1 5.2015
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, SRC, PRKCA, ADRB1, EGFR 4.3961
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP3A4, CYP2C19 4.9666
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, CACNA1C, EGFR, CDC25B, HSPA1A 3.5181
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, ADRB1, MET, EGFR, IGF1R, HSPA1A 3.4852
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA, CACNA1C 3.7149
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.4924
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, ADRB1, CACNA1C, PIK3CB 3.2843
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA, CACNA1C 3.5342
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 3.7791
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.7575
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.0952
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.9743
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, CHRM3, PRKCB, CA2, PRKCA 3.7149
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, ERBB2, PIK3CB, EGFR 3.9252
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PGR, PIK3CB, CDC25B, IGF1R 3.2278
Insulin secretion_Homo sapiens_hsa04911 PRKCG, CHRM3, PRKCB, PRKCA, CACNA1C 3.4688
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.1864
Purine metabolism_Homo sapiens_hsa00230 XDH 0.1965
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA, CACNA1C 3.408
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.9496
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.231
Salivary secretion_Homo sapiens_hsa04970 PRKCG, CHRM3, PRKCB, PRKCA, ADRB1 3.3936
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.2278
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2661
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.1927
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, PRKCA, CACNA1C, PTGS2 3.1783
Axon guidance_Homo sapiens_hsa04360 MET 0.2794
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, CHRM3, PRKCB, CA2, PRKCA 3.2577
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.8948
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.6617
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.5786
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.5786
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3481
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PRKCA, PIK3CB, EGFR 2.5564
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.5426
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3656
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5249
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.5426
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.4025
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3862
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 2.224
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.3995
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3849
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 0.8345
Peroxisome_Homo sapiens_hsa04146 XDH 0.4011
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 1.9987
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.0548
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.6842
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7122
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4011
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.0823
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.1145
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4149
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4131
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4169
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.8008
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.1908
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.1837
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.8111
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4453
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4282
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.045
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA, CACNA1C 2.1326
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.0662
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5421
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.0242
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.3242
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 1.9197
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA, CACNA1C 1.9792
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.4087
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.7823
Shigellosis_Homo sapiens_hsa05131 SRC 0.4666
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.3245
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.4511
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.9458
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9097
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.4583
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.8945
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 0.9097
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA, CACNA1C 2.4009
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.4211
Taste transduction_Homo sapiens_hsa04742 CHRM3, CACNA1C 0.9634
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.6617
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.5016
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2, CES1 4.6334
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.5369
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5249
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5249
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA, CACNA1C 2.908
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, CYP1A2, CYP1A1, AOX1, CYP1B1 4.9126
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.0535
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.5381
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA, CACNA1C 2.8938
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5426
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.5426
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.0682
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1, SLC5A1, CYP3A4 2.8088
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2 0.5426
Malaria_Homo sapiens_hsa05144 MET 0.5426
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.5426
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8505
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA, IGF1R 3.0553
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.0062
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, ERBB2, PIK3CB, EGFR 3.2577
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.1355
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1295
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 1.8925
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 1.8925
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 1.9508
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.5795
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 1.9792
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 1.9144
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.0042
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9508
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, SLC5A1, PIK3CB 3.4688
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.408
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6655
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, ALDH2, AKR1B1 2.0866
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7049
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7457
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6842
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2, AOX1 1.3551
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7049
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7199
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.1247
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.752
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7122
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7457
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.7457
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.6617
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.4992
Histidine metabolism_Homo sapiens_hsa00340 ALDH2 0.7812
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7194
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5984
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6692
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, ALDH2, AKR1B1 2.6356
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9197
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9817
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.317
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1023


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)