TCM-ID Component

Description of the Component

Component ID	TCMH2016
Latin Name	Retinervus luffae fructus
English Name	Luffa vegetable sponge
Chinese Pinyin Name	Si Gua Luo
中文名	丝瓜络
TCM Properties
TCM Meridians
Therapeutic Class English	For dispelling wind-dampness
Therapeutic Class Chinese	祛风湿
Functions	remove obstruction from the collaterals, promote blood circulation, and dispel wind
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx1109	Hua Mo Yan Capsule	滑膜炎胶囊
TCMFx1110	Hua Mo Yan Granules	滑膜炎颗粒
TCMFx4873	Hua Mo Yan Granules	滑膜炎颗粒
TCMFx94	Hua Mo Yan Tablets	滑膜炎片
TCMF5093	Qu Feng Oral Liquid	驱风液
TCMF5649	Ru He Nei Xiao Oral Liquid	乳核内消液
TCMFx5800	Sheng Ru Tablets	生乳片
TCMFx5629	Shu Re Gan Mao Granules	暑热感冒颗粒
TCMFx6993	Si Bai Qu Ban Ruan Ointment	丝白祛斑软膏
TCMFx5833	Tong Luo Sheng Ru Syrup	通络生乳糖浆
TCMF5331	Wu Di Yao Wine	无敌药酒

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name

Ingredient Structrues

Ingredient ID: TCMC6436
Formula: C30H46O3

Common Name	Machaerinic Acid Lactone
IUPAC Name	(1R,4S,5R,8R,10S,13R,14R,18S,21S)-10-hydroxy-4,5,9,9,13,20,20-heptamethyl-22-oxahexacyclo[19.2.1.01,18.04,17.05,14.08,13]tetracos-16-en-23-one
Canonical SMILES	O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@]13[C@H]2CC(C)(C)[C@H](C1)OC3=O)C)C
Standard InCHI	InChI=1S/C30H46O3/c1-25(2)16-19-18-8-9-21-27(5)12-11-22(31)26(3,4)20(27)10-13-29(21,7)28(18,6)14-15-30(19)17-23(25)33-24(30)32/h8,19-23,31H,9-17H2,1-7H3/t19-,20-,21+,22-,23-,27-,28+,29+,30+/m0/s1
Standard InCHIKey	PWZMNBAVCHYMBK-FMMUPTMQSA-N
External Identifiers	ChEMBL [N/A]; PubChem [21594250];
Reference of Component-Ingredient Pair	11243201

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH816	Albizzia julibrissin	He Huan Pi	合欢皮
TCMH2016	Retinervus luffae fructus	Si Gua Luo	丝瓜络

Ingredient ID: TCMC6371
Formula: C36H58O11

Common Name	Lucyoside R
IUPAC Name	(3S,4aR,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-3,11-dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Canonical SMILES	OC[C@H]1O[C@@H](O[C@H]2[C@H](O)C[C@]3([C@H]([C@]2(C)CO)CC[C@@]2([C@@H]3CC=C3[C@@]2(C)CC[C@@]2([C@H]3CC(C)(C)[C@H](C2)O)C(=O)[O-])C)C)[C@@H]([C@H]([C@@H]1O)O)O
Standard InCHI	InChI=1S/C36H58O11/c1-31(2)13-19-18-7-8-23-32(3)14-20(39)28(47-29-27(43)26(42)25(41)21(16-37)46-29)33(4,17-38)22(32)9-10-35(23,6)34(18,5)11-12-36(19,30(44)45)15-24(31)40/h7,19-29,37-43H,8-17H2,1-6H3,(H,44,45)/p-1/t19-,20+,21+,22+,23+,24-,25+,26-,27+,28-,29-,32-,33-,34+,35+,36+/m0/s1
Standard InCHIKey	XARTTWLFBGJXMU-VWIHJBPLSA-M
External Identifiers	ChEMBL [N/A]; PubChem [21155826];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2016	Retinervus luffae fructus	Si Gua Luo	丝瓜络

Ingredient ID: TCMC6366
Formula: C30H46O5

Common Name	Lucyin
IUPAC Name	(3S,4aR,6aR,6aS,6bR,8aR,9S,10S,12aR,14bS)-9-formyl-3,10-dihydroxy-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Canonical SMILES	O=C[C@]1(C)[C@@H](O)CC[C@]2([C@H]1CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC([C@H](C1)O)(C)C)C(=O)[O-])C)C
Standard InCHI	InChI=1S/C30H46O5/c1-25(2)15-19-18-7-8-21-26(3)11-10-22(32)27(4,17-31)20(26)9-12-29(21,6)28(18,5)13-14-30(19,24(34)35)16-23(25)33/h7,17,19-23,32-33H,8-16H2,1-6H3,(H,34,35)/p-1/t19-,20+,21+,22-,23-,26-,27-,28+,29+,30+/m0/s1
Standard InCHIKey	MFGKQCGZFKURGT-BGSMKCEQSA-M
External Identifiers	ChEMBL [N/A]; PubChem [21125937];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2016	Retinervus luffae fructus	Si Gua Luo	丝瓜络

Ingredient ID: TCMC4325
Formula: C29H48O

Common Name	Α-Spinasterol
IUPAC Name	(3S,5S,9R,10S,13R,14R,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Canonical SMILES	CC[C@@H](C(C)C)/C=C/[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1C2=CC[C@@H]2[C@]1(C)CC[C@@H](C2)O)C
Standard InCHI	InChI=1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h8-9,11,19-23,25-27,30H,7,10,12-18H2,1-6H3/b9-8+/t20-,21-,22+,23+,25-,26+,27+,28+,29-/m1/s1
Standard InCHIKey	JZVFJDZBLUFKCA-FXIAWGAOSA-N
External Identifiers	ChEMBL [N/A]; PubChem [5281331];
Reference of Component-Ingredient Pair	25757602

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH228	Bupleurum chinense	Chai Hu	柴胡
TCMH426	Codonopsis pilosula	Dang Shen	党参
TCMH101	Chelidonium majus	Bai Qu Cai	白屈菜
TCMH705	Trichosanthes kirilowii	Gua Lou	瓜蒌
TCMH1080	Platycodon grandiflorum	Jie Geng	桔梗
TCMH1588	Achyranthes bidentata	Niu Xi	牛膝
TCMH2016	Retinervus luffae fructus	Si Gua Luo	丝瓜络
TCMH2725	Fructus perillae	Zi Su Zi	紫苏子

Ingredient ID: TCMC4320
Formula: C32H46O8

Common Name	Cucurbitacin B
IUPAC Name	[(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate
Canonical SMILES	CC(=O)OC(/C=C/C(=O)[C@@]([C@H]1[C@H](O)C[C@@]2([C@]1(C)CC(=O)[C@@]1([C@H]2CC=C2[C@H]1C[C@H](O)C(=O)C2(C)C)C)C)(O)C)(C)C
Standard InCHI	InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1
Standard InCHIKey	IXQKXEUSCPEQRD-DKRGWESNSA-N
External Identifiers	ChEMBL [CHEMBL508185]; PubChem [5281316];
Reference of Component-Ingredient Pair	27145940

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH2016	Retinervus luffae fructus	Si Gua Luo	丝瓜络

Ingredient ID: TCMC3976
Formula: C30H48O3

Common Name	Bryonolic Acid
IUPAC Name	(2R,4aS,6aS,8aR,10S,12aS,14aS,14bR)-10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,3,4,5,6,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-2-carboxylic acid
Canonical SMILES	O[C@H]1CC[C@]2([C@H](C1(C)C)CCC1=C2CC[C@@]2([C@]1(C)CC[C@@]1([C@H]2C[C@@](C)(CC1)C(=O)[O-])C)C)C
Standard InCHI	InChI=1S/C30H48O3/c1-25(2)21-9-8-20-19(28(21,5)12-11-23(25)31)10-13-30(7)22-18-27(4,24(32)33)15-14-26(22,3)16-17-29(20,30)6/h21-23,31H,8-18H2,1-7H3,(H,32,33)/p-1/t21-,22+,23-,26+,27+,28+,29+,30-/m0/s1
Standard InCHIKey	BHVJSLPLFOAMEV-FPLINDMSSA-M
External Identifiers	ChEMBL [CHEMBL482596]; PubChem [472768];
Reference of Component-Ingredient Pair	11432464

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH86	Ampelopsis japonica	Bai Lian	白蔹
TCMH2086	Trichosanthes kirilowii	Tian Hua Fen	天花粉
TCMH2016	Retinervus luffae fructus	Si Gua Luo	丝瓜络

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC3976	C30H48O3	Bryonolic Acid	455.3525204	1.4497	4.43	7.826	3	1	60.36	1	5	33	1
TCMC4320	C32H46O8	Cucurbitacin B	558.3192684	0.7709	4.1	2.725	8	3	138.2	6	4	40	0
TCMC4325	C29H48O	Α-Spinasterol	412.3705162	1.2566	4.54	11.261	1	1	20.23	5	4	30	1
TCMC6366	C30H46O5	Lucyin	485.3266995	0.0445	4.21	5.89	5	2	97.66	2	5	35	1
TCMC6371	C36H58O11	Lucyoside R	665.3900876	-2.1814	4.21	3.005	11	7	200.2	5	6	47	2
TCMC6436	C30H46O3	Machaerinic Acid Lactone	454.3446953	2.1657	4.43	7.787	3	1	46.53	0	6	33	1

Download Data

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Retinervus luffae fructus 丝瓜络

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC6436

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC6371

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC6366

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC4325

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC4320

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC3976

Occurrence of the ingredient across TCM components

Properties

Download Data