TCM Prescription: Jian Bu Zhuang Gu Pills



Prescription Description
Prescription IDTCMF4929
Pinyin NameJian Bu Zhuang Gu Wan
Chinese Name健步壮骨丸
English NameJian Bu Zhuang Gu Pills
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH136 Os pardi 豹骨 TCMH136
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH746 Carapax et plastrum testudinis 龟甲 TCMH746
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2056 Cynomorium songaricum 锁阳 TCMH2056 ITSAO3649-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MAOB, MET, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS1, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TRPV1, XDH 18.9861
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, PIK3CA, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 16.5496
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, HSP90AB1, IGF1R, INSR, MAOB, MMP2, MMP9, PIK3CA, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SRC, TEK, TRPV1, TYR 16.0599
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, PIK3CA, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 13.7241
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 13.4018
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 13.3821
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, FLT3, HSP90AB1, MAOB, PPARG, PRKCE, PRKCG, PTAFR, PTGS2, RORC, SRC, TEK, TRPV1, TYR 12.4919
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, TRPV1 11.9803
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.4624
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 11.4624
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.3967
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.2855
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.2767
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 11.2298
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CHRM5, DRD1, DRD2, DRD3, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.2078
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 10.9497
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.91
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, GLO1, HMGCR, HSPA1A, PDE5A, PIK3CA, PIM1, PPARA, PPARG, PTAFR, PTGS1, PTGS2, TYR, XDH 10.8039
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.7915
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 10.7881
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 10.7267
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.6342
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6066
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SMAD3, SRC, TRPV1 10.5652
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SMAD3, SRC, TRPV1 10.5392
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HSP90AA1, HSP90AB1, INSR, MAOB, PTGS2, SLC1A1, SLC22A2, SLC22A3, SMAD3, TRPV1 10.5392
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, FABP3, FLT3, GRM5, IGF1R, INSR, MAOB, MMP2, PPARA, PPARG, PRKCD, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TRPV1 10.5389
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, PPARG, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 10.1616
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.1502
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, EGFR, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.1502
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, MET, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCE, SMAD3, SRC, TRPV1 10.1237
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.0336
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, MAOB, MMP9, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TRPV1 9.94456
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 9.94359
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.90916
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.88114
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 9.82768
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, SRC, TEK, TRPV1, TYR 9.8117
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8 9.8117
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 9.68614
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, PRKCB, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TRPV1, TYR 9.64526
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARG, PRKCA, PTAFR, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 9.52707
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, MAOB, PPARA, PPARG, PRKCD, PRKCE, PTAFR, PTGS2, SRC, TEK, TRPV1 9.42994
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SRC, TEK, XDH 9.3813
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HMGCR, HSP90AB1, KDR, MAOB, PPARG, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, SRC, TRPV1 9.34453
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 9.31094
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.28544
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, SRC, TEK, TRPV1, TYR 9.2057
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 9.18932
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, DRD1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SRC, TRPV1 9.15625
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR 9.06463
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.01112
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SRC, TEK, XDH 8.85574
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TEK, TOP2A, TYR, XDH 8.84994
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC, TEK, TRPV1 8.84994
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 8.8128
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 8.78782
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCE, SMAD3, TRPV1 8.7808
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.77128
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 8.77106
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 8.73093
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MAOB, MMP9, PRKCD, PTGS2, SRC 8.72684
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCE, PTGS2 8.66789
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCE, PTGS2 8.66789
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 8.62532
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PPARG, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 8.54929
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 8.54929
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 8.53954
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, PPARG, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 8.45626
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.42643
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.4123
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 8.39478
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.37106
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A, TRPV1 8.20672
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 8.17955
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 8.16189
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 8.16189
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 8.11544
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.11269
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 8.01562
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 7.93145
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8 7.93145
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.91047
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HMGCR, HSP90AA1, KDR, MAOB, PRKCD, PRKCE, SRC 7.87834
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HMGCR, HSD17B1, HSD17B2, MAOB, NQO2, PPARG, PTGS1, PTGS2, TYR, XDH 7.80723
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, HMGCR, HSD17B1, HSD17B2 7.8019
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, HSP90AB1, PPARG, PTAFR, PTGS2, RORC, SRC, TRPV1 7.78576
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 7.76083
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 7.75666
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.74667
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HMGCR, PPARA, PPARG, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 7.59295
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 7.58563
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 7.53721
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.47892
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.45657
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 7.38491
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, PRKCB, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 7.35099
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PDE5A, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 7.2999
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, MAOB, PPARG, PRKCE, PTAFR, PTGS2, RORC, SRC, TYR 7.27042
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PDE5A, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 7.24968
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8 7.212
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, EGFR, GPR35, GRM1, HCAR2, PDE5A, PRKCA, PTAFR, PTGS2, SLC1A1, SMAD3, TRPV1 7.15467
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, HSP90AB1, KDR, PRKCD, PRKCE, PTAFR, PTGS2, SRC, TRPV1 7.12885
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 7.0715
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 7.01449
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, HSP90AB1, NQO2, PTGS1, RORC 6.96901
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 6.94732
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 6.94732
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.94091
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.88275
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, HMGCR, KDR, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 6.88275
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PPARG, PTGS1, PTGS2 6.88275
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.87628
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.87628
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, HMGCR, MAOB, PTAFR, TYR 6.85826
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 6.84364
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 6.84364
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, INSR, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCD, PTPN1, SRC, TEK 6.84326
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRM1, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.77868
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 6.73966
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, GPR35, GRM1, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PIK3CA, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, TRPV1, XDH 6.66933
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 6.66746
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, PRKCG, PTGS2, SLC1A1, TEK, TRPV1 6.66191
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, RORC, SMAD3, SRC, TRPV1 6.60917
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC, TEK, XDH 6.60742
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, HSP90AB1, INSR, PPARG, PRKCD, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TRPV1 6.58007
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PRKCA, PTAFR, PTGS2, TEK 6.53278
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP9, PDE5A, PIM1, PPARG, PRKCA, PRKCB, PRKCE, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, TRPV1 6.53278
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 6.53278
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 6.51612
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 6.51612
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.50578
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HMGCR, HSD17B1, HSD17B2, PRKCA, PRKCE, SLC22A1 6.50578
[BP] GO:0015872 None CHRM5, DRD1, SLC22A1, SLC22A2, SLC22A3 6.35903
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 6.32577
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PPARG, PRKCD, PTAFR, PTGS2, SRC, TRPV1 6.28286
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.28005
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DRD1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PPARG, PRKCD, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TRPV1 6.19428
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, PPARA, PPARG, PRKCG, RORC, SRC, TOP2A 6.19049
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MAOB, MET, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 6.18057
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, PDE5A, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 6.14692
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.13935
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PPARG, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 6.08198
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PPARG, PRKCD, PTGS2, SRC, TEK, TRPV1 6.08198
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.07828
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, PPARA, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 6.01361
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.99494
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.9781
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, PDE5A, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 5.96481
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.963
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, HSP90AB1, INSR, KDR, MAOB, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A, TYR 5.93391
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 5.93374
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A 5.93117
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.91272
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PPARG, PRKCD, PTAFR, PTGS2, SRC, TRPV1 5.87973
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.87508
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.86855
[BP] GO:0051937 None CHRM5, DRD1, SLC22A1, SLC22A2, SLC22A3 5.86171
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 5.85117
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 5.85117
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 5.8481
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSP90AA1, HSP90AB1, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 5.81833
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSP90AB1, INSR, PRKCA, PRKCE, SRC 5.79423
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.77856
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.71658
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, KDR, PRKCE, SRC, TRPV1 5.69978
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MAOB, MET, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.68893
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2, EGFR, PRKCE, PTGS2 5.66337
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.66337
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, PDE5A, PIK3CA, PRKCG, PTAFR, PTGS2, SRC, TEK, TRPV1, TYR 5.6574
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, PRKCD, PRKCE, PTGS2, SRC, TEK 5.60589
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, GRM5 5.59663
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 5.59539
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.59059
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.59018
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, HSPA1A, MAOB 5.55049
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.55049
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.55049
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.51859
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.51859
[BP] GO:0050890 None ADORA1, APP, CHRM1, DRD1, DRD2, DRD3, EGFR, GRM5, HMGCR, INSR, PRKCG, PTGS2 5.51829
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.51829
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, PDE5A, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 5.50475
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CHRM1, DRD1, DRD2, DRD3, GPR35, GRM5, MAOB, MMP9, PRKCD, PRKCE, PTAFR, PTGS2 5.49318
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.46112
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CYP19A1, DRD2, DUSP3, ESR1, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PDE5A, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC 5.45196
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PDE5A, PIK3CB, PRKCD, PTPN1, SRC 5.3829
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, PDE5A, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 5.34621
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 5.34193
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.33758
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 5.32538
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1, TEK 5.32464
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PPARA, PPARG, PTGS1, PTGS2 5.31403
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.30825
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, PPARG, PRKCG, RORC, TOP2A 5.2345
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.15734
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 5.15408
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, DRD3, GPR35, MAOB, MMP9, PRKCE, PTGS2 5.1443
[BP] GO:0015844 None CHRM5, DRD1, SLC22A1, SLC22A2, SLC22A3 5.1279
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.1279
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARA, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.11194
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 5.09966
[BP] GO:0032409 None APP, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9, PPARG, PRKCD, PRKCE, PTAFR 5.0992
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 5.07793
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, PRKCD, SRC, TEK, TYR 5.07506
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PIK3CA, PIK3CB, PPARG, PTAFR, SRC 5.07506
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.04965
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.03341
[BP] GO:0009410 None DRD1, DRD2, DRD3, EGFR, HSP90AB1, PPARG, PRKCE, PRKCG, PTAFR 5.0333
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 5.0333
[BP] GO:0015893 None CA2, CHRM5, DRD1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.98864
[BP] GO:0008217 None ADORA1, DRD2, DRD3, PPARA, PPARG, PTAFR, PTGS1, PTGS2, SMAD3 4.96519
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, PDE5A, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 4.95378
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PDE5A, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, SMAD3, SRC, TEK 4.95292
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.94488
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.94488
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 4.93088
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 4.93088
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 4.9167
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.85893
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1, XDH 4.85273
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MAOB, MMP9, PTGS2 4.84092
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 4.82593
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2 4.81579
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PPARG, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.80164
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PPARG, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.74577
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, MAOB, TYR 4.74208
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1, XDH 4.72895
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1, TEK 4.7209
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.71461
[BP] GO:0007610 None APP, BCL2, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HMGCR, INSR, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 4.71173
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 4.68714
[BP] GO:0055065 metal ion homeostasis APP, BCL2, DRD1, DRD2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.66368
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, DRD2, F10, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 4.65366
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TOP2A 4.64061
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.63106
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, HMGCR, KDR, PRKCA, PTPN1, SRC, TEK 4.62061
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 4.60985
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, HMGCR, PPARA, PPARG, PRKCD, SMAD3, TEK 4.54541
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 4.53831
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, HSP90AB1, MET, MMP9, PPARA, PPARG, PRKCD, SMAD3, SRC 4.53384
[BP] GO:0016572 histone phosphorylation AURKB, DRD1, PRKCA, PRKCB, PRKCD 4.53324
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD17B2, HSP90AB1, INSR, KDR, PIK3CA, PPARA, PPARG, SMAD3, SRC, TEK, TYR 4.52973
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR, PTAFR, PTGS2 4.52973
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR, PTAFR, PTGS2 4.52973
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, DRD1, DRD2, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.51977
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CHRM1, DRD2, DRD3, EGFR, HCAR2, HMGCR, HSP90AB1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 4.51387
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR, HMGCR 4.5101
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 4.5101
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, PIK3CB, PTGS2 4.47899
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, EGFR, PDE5A, PTAFR, PTGS2, SLC1A1 4.47381
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.462
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.45419
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PPARG, PTAFR, PTGS2 4.43961
[BP] GO:0060359 None DRD1, DRD2, DRD3, HSP90AB1, PRKCE, PRKCG, PTAFR 4.42735
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD17B2, HSP90AB1, INSR, KDR, MAOB, MMP9, PIK3CA, PIM1, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.41603
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1, XDH 4.41431
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM5, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTPN1, SRC, TEK 4.39586
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, MAOB, PPARG, PRKCE, PTAFR, SRC 4.38997
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TOP2A 4.38222
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 4.37225
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PPARG, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.36755
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.36642
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, HSP90AB1, IGF1R, INSR, PDE5A, PIK3CB, PRKCD, PTPN1, SRC 4.36096
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR, PTAFR, PTGS2 4.35522
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, EGFR, GRM5, HMGCR, INSR, PRKCG, PTGS2 4.34831
[BP] GO:0043279 None DRD2, DRD3, HSP90AB1, PPARG, PRKCE, PRKCG, TRPV1 4.34526
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 4.33554
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, DRD1, EGFR, HMGCR, PTAFR, PTGS2 4.33554
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 4.28528
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2, PRKCE 4.27473
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.2696
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.26951
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, GRM5, HMGCR, INSR, PTGS2 4.26836
[BP] GO:0090066 None ADORA1, ALOX15, CHRM1, CHRM3, DRD1, EGFR, HMGCR, HSP90AB1, PRKCD, PRKCE, PTAFR, PTGS2 4.25163
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD2, DRD3, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PRKCD, PTAFR, SLC1A1, SLC22A2, TRPV1, XDH 4.23822
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, FABP4, GRM3, GRM8, HMGCR, HSP90AB1, HSPA1A, IGF1R, MET, MMP9, PIK3CA, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 4.11782
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 4.10778
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR, PRKCA 4.09055
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, PRKCD, PRKCE, SMAD3, SRC, TEK 4.06526
[BP] GO:0006855 None SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 4.06273
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, HMGCR, KDR, PRKCA, SRC, TEK 4.05749
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PPARG, PTAFR, PTGS2, TEK, TRPV1, TYR 4.05038
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.0365
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2 4.0365
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTAFR, PTGS2 4.03132
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, PRKCE, PTAFR, PTGS2, SRC 4.01016
[BP] GO:0050877 None ADORA1, APP, CHRM1, CHRM5, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, PRKCG, PTGS2, TRPV1, TYR 3.98629
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3, PRKCE 3.97791
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, HSP90AB1, MET, PIK3CA, PPARA, PRKCG, SMAD3 3.94242
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PRKCD, SRC 3.92804
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.92771
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.91882
[BP] GO:0042391 None ADORA1, APP, BCL2, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 3.9148
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 3.91117
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.88522
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, INSR, PPARG, PRKCD, SRC 3.88446
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, MAOB, PTAFR, PTGS2, SRC 3.87715
[BP] GO:0038128 None EGFR, HSP90AA1, PIK3CA, PRKCA, SRC 3.87409
[BP] GO:0070201 None ACHE, APP, BCL2, CHRM1, DRD2, DRD3, EGFR, HCAR2, HMGCR, HSP90AB1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.83405
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA, PRKCA 3.82551
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, XDH 3.81601
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PRKCD, PRKCG, SRC 3.80907
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, PRKCD, SRC, TEK 3.79547
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA, PRKCA 3.79547
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, PIK3CA, PIK3CB, SRC 3.79547
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, DRD2, DUSP3, ESR1, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC 3.78282
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PPARG, PRKCA, PRKCE, PTGS2, SRC, TEK 3.78158
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PPARG, PRKCD, PTGS2, SRC, TEK, TRPV1 3.75302
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.74664
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.74245
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, DRD2, DRD3, GPR35, HMGCR, HSPA1A, MAOB, MMP9, PRKCB, PRKCE, PTGS2 3.73199
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA, PTAFR 3.73109
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PPARG, PRKCD, SMAD3, TEK 3.72852
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PIK3CB, PPARG, PRKCG, PTPN1, SRC 3.72852
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, MAOB, PTAFR, PTGS2, SRC 3.72852
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOB 3.69046
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOB 3.69046
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.69046
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, HMGCR, PTGS2, TYR 3.67725
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET, PIK3CA, TRPV1 3.66692
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.64982
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.64544
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 3.62898
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.62381
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, PPARG, PRKCD, SMAD3, TEK 3.60454
[BP] GO:0022898 None APP, BCL2, DRD2, DRD3, GPR35, GRM5, MMP9, PRKCE, PTAFR 3.60454
[BP] GO:0090257 None ADORA1, CHRM1, CHRM2, CHRM3, PDE5A, PRKCA, PTAFR, PTGS2, SMAD3 3.60454
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, CHRM1, DRD2, EGFR, HCAR2, HSP90AB1, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.57991
[BP] GO:0070542 None FABP3, PPARG, PRKCE, PTAFR, PTGS2, SRC 3.56238
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, PRKCD, PRKCE, PTPN1, SRC 3.56163
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.55886
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.53293
[BP] GO:0051223 None ACHE, APP, CHRM1, DRD2, DRD3, EGFR, HCAR2, HMGCR, HSP90AB1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.52495
[BP] GO:1900542 None DRD1, DRD2, DRD3, GRM3, GRM8, INSR, PDE5A, PPARA, PRKCA 3.5215
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.51717
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PRKCD, PTAFR 3.51035
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG, PTGS2, TYR 3.51035
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, GRIK5, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PPARG, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 3.49064
[BP] GO:0060341 regulation of cellular localization APP, BCL2, CHRM1, CSNK2A1, DRD1, DRD2, DRD3, EGFR, GRIK5, HMGCR, HSP90AB1, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.49064
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 3.49064
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3, HMGCR 3.4796
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.4796
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.44735
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.44735
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.44492
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.44492
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.44492
[BP] GO:0006140 None DRD1, DRD2, DRD3, GRM3, GRM8, INSR, PDE5A, PPARA, PRKCA 3.4386
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, MAOB 3.43533
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, HSP90AB1, PRKCD, PTGS2, SMAD3, SRC 3.43113
[BP] GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 3.43113
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTAFR, PTGS2, TEK, TRPV1, TYR 3.43113
[BP] GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 3.43113
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, GRM3, GRM8, HMGCR, HSP90AB1, HSPA1A, IGF1R, MMP9, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 3.42809
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8, PRKCA 3.40902
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, PRKCE, PTAFR, SRC, TRPV1 3.39693
[BP] GO:0002431 Fc receptor mediated stimulatory signaling pathway HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 3.39145
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.38695
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.38695
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.36702
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.36702
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.36702
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PRKCE 3.36286
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.3626
[BP] GO:0038094 Fc-gamma receptor signaling pathway HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 3.35732
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.35081
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PIK3CA, PPARG, PRKCD, PRKCG, SRC 3.3469
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARG, PRKCD, PTGS2, SMAD3, TEK 3.3469
[BP] GO:0010676 None INSR, PPARA, PRKCE, PTAFR, SRC 3.34054
[BP] GO:0050994 None ADORA1, HCAR2, PPARA, PRKCD, PRKCE 3.34054
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3, HMGCR 3.30224
[BP] GO:0015696 None CHRM5, DRD1, SLC22A1, SLC22A2, SLC22A3 3.30224
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, HMGCR, PPARG, PTGS2, TRPV1, TYR 3.27717
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, HMGCR, MAOB, PRKCA, PRKCE, PTAFR, SRC, TRPV1 3.27092
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, MAOB, PTAFR, PTGS2 3.26642
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.26335
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, HCAR2, HMGCR, HSP90AB1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.25494
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PPARA, PPARG, PRKCD, PTAFR, PTGS2, RORC, SMAD3, SRC, TOP2A, TRPV1 3.25146
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.22826
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, CHRM1, DRD2, EGFR, HCAR2, HSP90AB1, PRKCD, PRKCE, PTGS2, SMAD3, SRC 3.22087
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, HSD17B2, HSP90AB1, INSR, MMP2, MMP9, PPARG, PTAFR, PTGS2, SRC, TOP2A 3.21919
[BP] GO:0030799 None DRD1, DRD2, DRD3, GRM3, GRM8, PDE5A, PRKCA 3.21879
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.20841
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.20256
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PRKCB, PRKCD, PRKCE, PTAFR, RORC, SMAD3, TRPV1 3.19963
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, PRKCE, SRC, TRPV1 3.18285
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PDE5A, PIK3CB, PTPN1, SRC 3.17012
[BP] GO:0072347 None DRD2, DRD3, HSP90AB1, PRKCE, PRKCG 3.16959
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSP90AA1, HSPA1A, MAOB, MMP1, MMP2, MMP9, PDE5A, PIK3CB, SRC, XDH 3.16547
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOB 3.15099
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, DRD2, F3, HMGCR, HSP90AB1, INSR, KDR, PDE5A, PIM1, PPARG, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK 3.15099
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 3.15099
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, HSP90AB1, PRKCD, PTGS2, SMAD3 3.13495
[BP] GO:0030817 None DRD1, DRD2, DRD3, GRM3, GRM8, PRKCA 3.13495
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.11447
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 3.10373
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC 3.10372
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH 3.10372
[BP] GO:0035303 None ADORA1, CHRM5, DRD2, HSP90AB1, NUAK1, PRKCD, SMAD3 3.10077
[BP] GO:1904591 positive regulation of protein import APP, EGFR, HSP90AB1, PRKCD, PTGS2, SMAD3 3.09178
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.08903
[BP] GO:0019229 None CHRM1, CHRM3, EGFR, PTAFR, PTGS2 3.07393
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 3.06365
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR, PRKCE 3.05984
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 3.04702
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 3.04469
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.04469
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.04469
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, HMGCR, MAOB, PRKCA, PRKCE, PTAFR, SRC 3.03176
[BP] GO:0045936 None DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 3.03139
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.03139
[BP] GO:0010563 None DRD2, DRD3, DUSP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, PPARA, PRKCA, PRKCD, PTPN1, XDH 3.02499
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK 3.0235
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, HSP90AB1, INSR, PDE5A, PIK3CB, PTPN1, SRC 3.00699
[BP] GO:0001659 None ADORA1, DRD1, DRD2, TRPV1 2.99695
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, PTGS2, SRC 2.98368
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 2.97498
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HMGCR, PPARG, PTGS2, SRC, TRPV1, TYR 2.97461
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.97361
[BP] GO:0043086 negative regulation of catalytic activity APP, CSNK2A1, DRD2, DRD3, DUSP3, FABP4, GRM3, HMGCR, IGF1R, MMP9, PPARG, PRKCA, PRKCD, PTGS2, PTPN1, SRC 2.96794
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.96207
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, PTGS2 2.96097
[BP] GO:0007194 None DRD2, DRD3, GRM3, PRKCA 2.95233
[BP] GO:0043278 None DRD2, DRD3, PRKCE, PRKCG 2.95233
[BP] GO:0014072 None DRD2, DRD3, PRKCE, PRKCG 2.95233
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, GPR35, GRM1, GRM5, PRKCE, SMAD3, TRPV1 2.95129
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, PPARA, PPARG, PRKCD, PTAFR, PTGS2, RORC, SMAD3, SRC, TOP2A, TRPV1 2.94014
[BP] GO:0034762 None APP, BCL2, CA2, DRD1, DRD2, DRD3, GPR35, GRM5, MMP9, PRKCE, PTAFR 2.92462
[BP] GO:0035408 None PRKCA, PRKCB 2.92376
[BP] GO:0006937 None ADORA1, CHRM1, CHRM2, CHRM3, PDE5A, PTAFR, PTGS2 2.92302
[BP] GO:0032412 None APP, DRD2, DRD3, GPR35, GRM5, MMP9, PRKCE, PTAFR 2.91155
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, HMGCR, PTAFR, TYR 2.90737
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD1, DRD2, DRD3, FABP3, HSP90AA1, PPARA, PPARG, PRKCB, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 2.89179
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK 2.88945
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, DRD3, PIK3CA 2.8816
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA, PPARG 2.8816
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.87684
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.87684
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.87684
[BP] GO:0002684 positive regulation of immune system process APP, AXL, BCL2, CA2, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, SRC 2.87082
[BP] GO:0031280 None DRD2, DRD3, GRM3, PRKCA 2.86694
[BP] GO:0045913 None INSR, PPARA, PRKCE, PTAFR, SRC 2.85888
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3, PRKCE 2.85888
[BP] GO:0035304 regulation of protein dephosphorylation ADORA1, DRD2, HSP90AB1, NUAK1, PRKCD 2.85888
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.82963
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.82963
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4, MAOB 2.82358
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 2.82221
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.82107
[BP] GO:0030814 None DRD1, DRD2, DRD3, GRM3, GRM8, PRKCA 2.7849
[BP] GO:0051350 None DRD2, DRD3, GRM3, PRKCA 2.77862
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.77862
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.77862
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.77862
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3, HMGCR 2.77862
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.76524
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, HMGCR, HSP90AB1, INSR, KDR, NUAK1, PDE5A, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.75602
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.75232
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.75232
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH 2.75232
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.73782
[BP] GO:0030802 None DRD1, DRD2, DRD3, GRM3, GRM8, PRKCA 2.73465
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, PPARA, PPARG, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TOP2A 2.73347
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK 2.72794
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, PPARG, RORC, SRC 2.72794
[BP] GO:0010675 None INSR, PPARA, PRKCE, PTAFR, RORC, SRC 2.69942
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.69942
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.69165
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.69165
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.68652
[BP] GO:0032413 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.68069
[BP] GO:0007626 None APP, DRD1, DRD2, DRD3, GRM1, GRM5, PRKCE 2.67236
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, PPARG, SMAD3 2.66306
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.66122
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 2.65662
[BP] GO:0046717 None CHRM5, DRD2, DRD3, SLC1A1, TRPV1 2.63006
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD17B1, HSD17B2 2.61197
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.60603
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.6058
[BP] GO:1903829 positive regulation of cellular protein localization APP, BCL2, CHRM1, EGFR, HSP90AB1, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.60136
[BP] GO:0060627 regulation of vesicle-mediated transport ALOX15, APP, AXL, DRD2, GRIK5, PIK3CB, PPARG, PRKCG, PTAFR, PTPN1, SRC 2.58984
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 2.58258
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.56765
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.56611
[BP] GO:1900371 None DRD1, DRD2, DRD3, GRM3, GRM8, PRKCA 2.56088
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HMGCR, PPARG, PTGS2, SRC, TRPV1, TYR 2.56088
[BP] GO:0051336 regulation of hydrolase activity APP, CSNK2A1, DRD2, EGFR, ESR1, F3, HSP90AB1, HSPA1A, MMP9, NUAK1, PPARG, PRKCD, PTAFR, PTGS2, PTPN1, SMAD3, SRC, XDH 2.5489
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 2.54503
[BP] GO:0030808 None DRD1, DRD2, DRD3, GRM3, GRM8, PRKCA 2.54503
[BP] GO:1901655 None AKR1B1, EGFR, PPARG, PRKCE, SRC 2.53604
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.53274
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.52926
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.52926
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.52926
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.52926
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.52926
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, PPARG, PRKCA, PRKCB, PTGS2, TEK, XDH 2.52006
[BP] GO:0099566 None GRM1, GRM5 2.52001
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.52001
[BP] GO:0060160 None DRD2, DRD3 2.52001
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52001
[BP] GO:0001936 None F3, KDR, PPARG, PRKCA, TEK, XDH 2.50527
[BP] GO:0038127 None EGFR, HSP90AA1, PIK3CA, PRKCA, SRC 2.50301
[BP] GO:0001816 cytokine production APP, FABP4, PRKCD, PTAFR, PTGS2 2.50301
[BP] GO:0032410 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.50301
[BP] GO:1904063 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.50301
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, PPARG, RORC 2.49211
[BP] GO:0071229 cellular response to acid chemical EGFR, KDR, MMP2, PPARG, PRKCE, PTAFR, SRC 2.48746
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, HSP90AB1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.48352
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, PRKCE 2.48182
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HMGCR, PRKCA, PRKCE 2.47247
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.46559
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.46493
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3, PPARG 2.462
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD 2.462
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.462
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, PPARG 2.45432
[BP] GO:0045761 None DRD2, DRD3, GRM3, PRKCA 2.45274
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, DRD3, EGFR, HMGCR, PTGS2, TYR 2.44429
[BP] GO:0032870 cellular response to hormone stimulus APEX1, EGFR, ESR1, FLT3, INSR, PPARG, PRKCD, PRKCE, SRC 2.42689
[BP] GO:0045088 regulation of innate immune response DRD2, ESR1, HSP90AB1, HSPA1A, MMP2, PPARG, PRKCD, PRKCE, PTPN1, SRC 2.42106
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.4022
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.396
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, APP, AXL, DRD2, DRD3, HSP90AA1, SLC1A1, SLC22A3, TRPV1 2.39056
[BP] GO:1903827 regulation of cellular protein localization APP, BCL2, CHRM1, CSNK2A1, EGFR, HSP90AB1, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.38901
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CYP1B1, DRD2, FABP3, HSPA1A, PDE5A, PPARG, PTGS2, SMAD3, XDH 2.38901
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, MAOB 2.35282
[BP] GO:0061041 regulation of wound healing F3, HMGCR, PRKCA, PRKCD, PRKCE, SMAD3 2.35245
[BP] GO:0006939 None CHRM3, DRD1, DRD2, TRPV1 2.35138
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTAFR, PTGS1, PTGS2, TRPV1 2.34643
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.33337
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.33337
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP9, PIK3CA, PIK3CB, PRKCD, PTAFR, SRC, TEK 2.33082
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.32322
[BP] GO:0035306 None ADORA1, HSP90AB1, PRKCD, SMAD3 2.32322
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, PTAFR, PTGS1, PTGS2 2.3207
[BP] GO:0071396 cellular response to lipid AXL, EGFR, ESR1, FLT3, PPARG, PRKCE, PTAFR, RORC, SRC 2.3207
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, PRKCA, PTGS2, SMAD3 2.31909
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, PPARG 2.30908
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.28858
[BP] GO:0051248 None APP, CSNK2A1, DUSP3, EGFR, FABP4, HMGCR, HSP90AB1, HSPA1A, IGF1R, MMP9, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, XDH 2.28196
[BP] GO:0034766 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.27775
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.27455
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.27455
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.27455
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CYP1A1, DRD1, DRD2, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, KDR, MET, MMP2, MMP9, PPARG, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A 2.268
[BP] GO:1901374 None SLC22A1, SLC22A2 2.26481
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.26481
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.26481
[BP] GO:0015874 None SLC22A1, SLC22A2 2.26481
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.26481
[BP] GO:0009266 None ADORA1, HSP90AA1, HSPA1A, PPARG, PTGS2, TRPV1 2.26294
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.2505
[BP] GO:0051591 None APEX1, APP, PTAFR, TEK, TYR 2.2465
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH 2.23935
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, EGFR, HCAR2, HMGCR, PRKCA, PRKCE, SRC 2.23535
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 2.23472
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.22215
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.22215
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.22215
[BP] GO:0071398 None PPARG, PRKCE, PTAFR, SRC 2.21215
[BP] GO:0015909 None DRD2, DRD3, FABP3, PPARG 2.21215
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, GRM5, PTGS2 2.20812
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, DRD3, EGFR, HMGCR, MAOB, PPARG, PRKCD, PTAFR, PTGS2, SMAD3, SRC, TRPV1, TYR 2.20176
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.19114
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, HSP90AB1, PRKCD, PTGS2, SMAD3, SRC 2.18571
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.18414
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.18414
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MMP9, NUAK1, PPARG, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TOP2A, TRPV1 2.18195
[BP] GO:0010594 regulation of endothelial cell migration KDR, MET, PPARG, PRKCA, PTGS2, TEK 2.18195
[BP] GO:0034763 None DRD2, DRD3, GPR35, MMP9, PRKCE 2.17431
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, PPARG 2.17048
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.16856
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.16856
[BP] GO:0045765 regulation of angiogenesis CYP1B1, F3, KDR, PPARG, PRKCA, PRKCB, PTGS2, TEK 2.16235
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.16003
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.16003
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.16003
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.16003
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.16003
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.15911
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, PRKCE, SRC 2.14821
[BP] GO:0002429 immune response-activating cell surface receptor signaling pathway BCL2, HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, SRC 2.14393
[BP] GO:2000243 None INSR, PDE5A, PTAFR, SRC 2.13397
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.11951
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.11951
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11951
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.10709
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 2.10695
[BP] GO:0045785 positive regulation of cell adhesion ALOX15, KDR, PIK3CA, PRKCA, PRKCE, PTAFR, SMAD3, SRC, TEK 2.09132
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.0902
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, PRKCD, PTGS2 2.08685
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, CYP1B1, ESR1, ESR2, HSPA1A, PIM1, PPARG, PRKCB 2.08538
[BP] GO:0021853 None DRD1, DRD2 2.08022
[BP] GO:0046541 None CHRM1, CHRM3 2.08022
[BP] GO:0010641 None F3, SRC 2.08022
[BP] GO:0090325 None DRD2, DRD3 2.08022
[BP] GO:0007598 None F10, F3 2.08022
[BP] GO:0046618 None SLC47A1, SLC47A2 2.08022
[BP] GO:1904936 None DRD1, DRD2 2.08022
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.08022
[BP] GO:0042321 None ADORA1, DRD2 2.08022
[BP] GO:0010891 None PPARA, PPARG 2.08022
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, KDR, PRKCE, SMAD3, TEK 2.08017
[BP] GO:0051894 None KDR, SMAD3, TEK 2.07744
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.07744
[BP] GO:0061900 None APP, EGFR, TRPV1 2.07744
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, HSP90AB1, PRKCA, PTGS2, SRC, TRPV1 2.0773
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, PPARG 2.06178
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, PPARA, PPARG, RORC, SRC 2.05079
[BP] GO:0043254 regulation of protein complex assembly ALOX15, ESR1, HSP90AA1, HSPA1A, MET, MMP1, PRKCD, PRKCE, SRC 2.04895
[BP] GO:1903034 regulation of response to wounding F3, HMGCR, PRKCA, PRKCD, PRKCE, SMAD3 2.03802
[BP] GO:0002252 None ALOX5, APP, BCL2, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PIK3CA, PIK3CB, PRKCD, PRKCE, PTAFR, RORC, SRC 2.03055
[BP] GO:0050927 None F3, KDR, SMAD3 2.02975
[BP] GO:0045932 None ADORA1, PDE5A, PTGS2 2.02975
[BP] GO:0048169 None APP, DRD2, GRM5 2.02975
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, APP, AXL, BCL2, DRD2, DRD3, EGFR, GPR35, HSP90AB1, PDE5A, PPARG, PRKCD, PTGS2, SMAD3, TEK, XDH 2.02895
[BP] GO:0031279 None DRD2, DRD3, GRM3, PRKCA 2.01558
[BP] GO:0048015 phosphatidylinositol-mediated signaling IGF1R, PIK3CA, PIK3CB, PTAFR 2.01558
[BP] GO:0052548 None APP, CSNK2A1, F3, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH 2.01558
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, HMGCR, HSPA1A, MET, PDE5A, PIK3CA, PIK3CB, PTAFR, PTGS2, XDH 2.00679
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TRPV1 10.944
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, INSR, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SRC, TEK, TRPV1 10.5562
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MAOB, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TRPV1, TYR 9.46141
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PRKCG, PTAFR, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SRC, TEK, TRPV1 9.12783
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 8.77334
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MAOB, MET, PIK3CA, PIK3CB, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TEK, TRPV1, TYR 8.0401
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 7.2999
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, TRPV1 6.14289
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, SLC22A2, SRC, TRPV1 6.08604
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, HSP90AB1, SLC22A1, TEK 4.25253
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC, TRPV1 4.15749
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC, TRPV1 4.15749
[CC] GO:0014069 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 4.043
[CC] GO:0099572 None ADORA1, CHRM1, DRD2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 4.043
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MAOB, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TOP2A, TRPV1, TYR, XDH 3.91117
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 3.83685
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HMGCR, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 3.70279
[CC] GO:0098793 None ADORA1, APP, CHRM1, CHRM2, CHRM3, DRD2, GRIK5, SLC22A2 3.68943
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PRKCG, PTGS2, SRC 3.46118
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, HSP90AA1, HSP90AB1, INSR, SRC, TRPV1 3.35248
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R, INSR, SMAD3 3.27895
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TYR 3.25357
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PRKCG, PTGS2, SRC, TEK 3.10372
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PRKCG, PTGS1, PTGS2, SLC22A2, SRC, TRPV1 3.04426
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, F10, FLT3, GRIA2, HMGCR, HSD17B2, PTGS1, PTGS2, PTPN1 3.03343
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.01767
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM1, CHRM2, CHRM3, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PRKCG, PTGS2, SRC, TEK 2.96207
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP2, MMP9, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 2.90538
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, GRIA2, HMGCR, HSD17B2, PTGS1, PTGS2 2.80585
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.75232
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.7187
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, IGF1R, INSR, KDR, MAOB, MET, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TEK, TRPV1, TYR 2.66539
[CC] GO:0031982 None AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DRD2, DRD3, DUSP3, EGFR, F3, FABP3, FABP4, GLO1, GRIA4, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MAOB, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, PTPN1, SLC1A1, SLC22A2, SLC47A1, SRC, TYR 2.62612
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2 2.50301
[CC] GO:0030054 cell junction ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, GRIA2, GRIA4, GRIK5, HCAR2, HSPA1A, KDR, PRKCD, PRKCG, TEK, TRPV1 2.49184
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A2, SLC47A1, SMAD3, SRC, TOP2A, TYR, XDH 2.39572
[CC] GO:1903561 None AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F3, FABP3, FABP4, GLO1, GRIA4, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MAOB, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC1A1, SLC22A2, SRC 2.34458
[CC] GO:0043230 None AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F3, FABP3, FABP4, GLO1, GRIA4, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MAOB, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC1A1, SLC22A2, SRC 2.34441
[CC] GO:0031233 None CA4, F10, F3 2.27455
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.23472
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.16003
[CC] GO:0070062 None AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F3, FABP3, FABP4, GLO1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MAOB, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC1A1, SLC22A2, SRC 2.14393
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A2, SLC47A1, SMAD3, SRC, TOP2A, TYR, XDH 2.12113
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B2, IGF1R, INSR, KDR, MAOB, MET, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TEK, TRPV1, TYR 2.03407
[CC] GO:0031090 None ALOX5, APP, BCL2, CA4, CHRM2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, FUT7, GRIA2, GRIA4, HMGCR, HSP90AB1, INSR, MAOB, PRKCA, PTAFR, PTGS1, PTGS2, SMAD3, SRC, TYR 2.02036
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TYR, XDH 16.6065
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.6885
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 15.2097
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 13.4603
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TEK, TOP2A, TYR, XDH 11.9803
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, PTAFR, RORC, TEK, TRPV1 10.6597
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.8496
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.76994
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, PRKCE, PTAFR, RORC, SMAD3, TEK, TRPV1 9.65436
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, F10, GLO1, MMP1, MMP2, MMP9, NQO2, NUAK1, PDE5A, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TOP2A, TRPV1, TYR, XDH 9.60562
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5 9.50294
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 9.46141
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, PTAFR, RORC, TEK, TRPV1 9.46141
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARA, PPARG, PTAFR, RORC, TEK, TRPV1 9.13683
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, PTAFR, TEK, TRPV1 9.01112
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, PTAFR, TEK, TRPV1 9.01112
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HMGCR, HSD17B1, HSD17B2, MAOB, NQO2, PTGS1, PTGS2, TYR, XDH 8.68933
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, NQO2, PPARA, PPARG, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3 8.60459
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.20672
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.72878
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 7.6726
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, F10, GLO1, MMP1, MMP2, MMP9, NQO2, NUAK1, PDE5A, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TOP2A, TRPV1, TYR, XDH 7.38491
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 7.35081
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 7.20956
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.19125
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 6.87628
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, XDH 6.74678
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 6.73821
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.68847
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.64491
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.56802
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TYR 6.4931
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.28005
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.24662
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.24386
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 6.08509
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HMGCR, HSD17B1, MAOB, NQO2, PTGS1, PTGS2, SRC, XDH 6.01361
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 5.93391
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.8921
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.71658
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.56547
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.55049
[MF] GO:0019899 enzyme binding APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F3, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, MET, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 4.99788
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 4.99788
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MAOB, MET, MMP9, NQO2, PPARG, PTGS2, SLC22A1, SMAD3, TOP2A, TRPV1, TYR, XDH 4.95275
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 4.86409
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 4.86103
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.64923
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NQO2 4.51537
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.48305
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.43802
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.36642
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.83506
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, PRKCB, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TOP2A 3.74546
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.74245
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, PRKCB, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TOP2A 3.72852
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PPARG, PTPN1, SMAD3 3.7219
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TEK, TOP2A, TRPV1 3.69046
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, F10, F3, FABP3, FABP4, HSD17B1, PPARA, PPARG, PTAFR, RORC, TRPV1 3.63361
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG, PTAFR 3.55886
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.51314
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.47075
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.46021
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG, RORC 3.44492
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.44492
[MF] GO:0035258 None ESR1, FLT3, PPARG, PRKCB, SMAD3, SRC 3.36336
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, XDH 3.32182
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5, PDE5A 3.29166
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 3.24825
[MF] GO:0015238 None SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.22087
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 3.22087
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.22087
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.22087
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.22087
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.16959
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, PPARG, RORC 3.10373
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.04469
[MF] GO:0097159 organic cyclic compound binding ADORA1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.04085
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR, XDH 2.97361
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.97361
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 2.96207
[MF] GO:0042803 protein homodimerization activity ACHE, BCL2, DRD2, FLT3, HMGCR, HSP90AA1, HSP90AB1, MAOB, NQO2, PTGS2, SLC22A1, SMAD3, TOP2A, TYR, XDH 2.93704
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 2.93704
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 2.93423
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.92376
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.92376
[MF] GO:0008389 None CYP2A13, CYP2A6 2.92376
[MF] GO:0035403 None PRKCA, PRKCB 2.92376
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PDE5A, PTPN1 2.88083
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.87684
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.87684
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 2.82251
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.77862
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PPARG, PTPN1 2.75232
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 2.73465
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, AXL, BCL2, DRD2, EGFR, FLT3, HMGCR, HSP90AA1, HSP90AB1, MAOB, NQO2, PPARG, PTGS2, SLC22A1, SMAD3, TOP2A, TYR, XDH 2.72998
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD1, DRD2, DRD3 2.72998
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.69942
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 2.61242
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.52001
[MF] GO:0015307 None SLC47A1, SLC47A2 2.52001
[MF] GO:1901375 None SLC22A1, SLC22A2 2.52001
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.52001
[MF] GO:0005333 None SLC22A1, SLC22A2 2.52001
[MF] GO:0005277 None SLC22A1, SLC22A2 2.52001
[MF] GO:0099583 None GRM1, GRM5 2.52001
[MF] GO:0008513 None SLC22A1, SLC22A2 2.52001
[MF] GO:0004699 None PRKCD, PRKCE 2.52001
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.46559
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, HSD17B1, RORC 2.44049
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.35138
[MF] GO:1901363 heterocyclic compound binding ADORA1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, EGFR, ESR1, ESR2, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NQO2, NUAK1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.34855
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.33337
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.33337
[MF] GO:0035257 None ESR1, FLT3, PPARG, PRKCB, SMAD3, SRC 2.28295
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.27455
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.26481
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.26481
[MF] GO:0004971 None GRIA2, GRIA4 2.26481
[MF] GO:0051425 None APP, INSR 2.26481
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.26481
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PDE5A, PTPN1 2.1374
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR 2.0902
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.08022
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.08022
[MF] GO:0043559 insulin binding IGF1R, INSR 2.08022
[MF] GO:0015101 None SLC22A1, SLC22A2, SLC22A3 2.07744
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.02975


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GPR35, GRIK5, CHRM5, PTAFR, TRPV1, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4 13.4332
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.4036
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, PIK3CA, HSPA1A 12.4961
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, HSP90AA1, SMAD3, HSP90AB1, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, PIK3CA, BCL2, PPARG, MET 9.8499
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 9.7455
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.7455
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, CHRM3, CHRM1, PIK3CA, PRKCB, CHRM5, BCL2, PRKCA, PIK3CB 9.3575
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, PRKCG, GRIA2, GRM5, PRKCB, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 9.2878
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 8.9281
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, KDR, TEK, DRD2, MET 8.7642
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, CHRM3, GRM5, CHRM1, PRKCB, CHRM5, PTAFR, PRKCA, DRD1, GRM1, EGFR 8.4977
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 8.5246
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, MAOB, PRKCB, CYP2D6, ALOX5, ALOX15, PRKCA, PTGS2, PTGS1 8.2343
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, CHRM1, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, KDR, BCL2, TEK, MET 7.4494
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, PRKCA, PIK3CB, TRPV1 7.5415
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.863
Gap junction_Homo sapiens_hsa04540 PRKCG, GRM5, PRKCB, SRC, PRKCA, DRD1, DRD2, GRM1, EGFR 7.9045
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 7.4506
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, PIK3CA, BCL2, PIM1, CYP1B1, MET 7.2707
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, PIK3CA, ADORA1, PIK3CB, DRD1, DRD2, PPARA, GRIA4 7.1331
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 7.0848
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.329
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.3036
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 6.6621
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 6.9547
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, GRIA2, MAOB, PRKCB, PRKCA, DRD1, DRD2, DRD3, GRIA4 6.7289
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.0241
Hepatitis B_Homo sapiens_hsa05161 PRKCG, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 6.3594
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PRKCA, PIK3CB, GRM1, EGFR 6.3985
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, PTGS2, GRM1, GRIA4 6.4425
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.8921
Glioma_Homo sapiens_hsa05214 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 6.494
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 6.2236
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, GRIA2, MAOB, PRKCB, PRKCA, DRD1, GRIA4 6.4425
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 6.7997
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 5.6463
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 5.7025
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 5.0777
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.5379
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOB, ALOX15, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.5979
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 4.9094
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.9094
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 5.6221
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.5979
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR 4.2136
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1 5.2261
Long-term depression_Homo sapiens_hsa04730 PRKCG, GRIA2, PRKCB, PRKCA, GRM1, IGF1R 5.4633
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.4911
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 4.4998
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, CDC25B, IGF1R 4.3308
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 6.4887
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PRKCE, ADORA1, PDE5A, PIK3CB 4.0283
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PPARG, PIK3CB, HMGCR, IGF1R 3.8386
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 3.012
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.9825
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PPARG, PIK3CB, IGF1R 3.4209
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.2564
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.4054
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA, DRD1 3.4811
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.0521
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2023
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2253
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.3187
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2487
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 3.9582
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.1418
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.9355
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.3539
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.012
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2848
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, CHRM3, PRKCB, CA2, PRKCA 3.8847
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, CHRM3, PRKCB, CA2, PRKCA 3.39
Axon guidance_Homo sapiens_hsa04360 MET 0.2987
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.7791
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3061
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 2.991
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.7005
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3664
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP2D6, CYP1A2, CYP3A4 4.0114
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3844
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.5251
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.5686
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5642
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4029
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 2.3423
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.1059
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 4.679
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4001
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4162
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.2982
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4014
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6916
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 0.7265
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.0114
Peroxisome_Homo sapiens_hsa04146 XDH 0.4179
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 0.9083
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1394
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.2019
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 2.2356
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB, DRD1, DRD2 4.6432
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7645
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.0289
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.1417
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.997
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.8579
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.2654
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 1.9996
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.2902
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.1631
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.0215
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4755
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.8687
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2, HSPA1A 1.7242
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.4232
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.9743
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PPARG, PIK3CB 1.3229
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 1.8125
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 1.9024
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.8761
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 1.9574
Shigellosis_Homo sapiens_hsa05131 SRC 0.4998
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5028
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9654
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.5253
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.7199
Insulin secretion_Homo sapiens_hsa04911 PRKCG, CHRM3, PRKCB, PRKCA 2.6513
Salivary secretion_Homo sapiens_hsa04970 PRKCG, CHRM3, PRKCB, PRKCA 2.5914
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.6048
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.0228
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.6373
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.7716
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.5802
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.547
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.012
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5511
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5511
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0508
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 1.1078
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.0242
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.0973
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.5691
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1, HMGCR, CYP3A4 2.9158
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.126
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.574
Malaria_Homo sapiens_hsa05144 MET 0.5789
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2327
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 1.9574
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 1.9574
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.0183
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 1.9024
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.0423
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.188
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 1.9743
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0183
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.2813
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2607
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.5178
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.6544
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6544
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6988
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.3055
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3633
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.7597
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7385
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7825
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7192
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.4684
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1 3.7894
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.4453
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7921
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7488
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5569
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7825
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.7496
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8216
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7747
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, TYR 1.6568
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.637
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7242
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9722
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8542
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9485
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9698
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0228
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2092


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)