| GO Term |
GO Name |
Enriched Genes |
Log10 Adjusted P-value |
|
[BP] GO:0042221 |
response to chemical
|
ABCB1, ABCG2, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, MMP9, MPO, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RORC, SMAD3, SRC, TEK, TYR |
17.0765 |
|
[BP] GO:0010033 |
response to organic substance
|
AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR5A, IDO1, IGF1R, INSR, KDR, KIT, MMP2, MPO, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RORC, SMAD3, SRC, TEK, TYR |
16.6602 |
|
[BP] GO:0065008 |
regulation of biological quality
|
ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, INSR, KDR, KIT, MET, MIF, MTNR1B, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH |
16.6602 |
|
[BP] GO:1901700 |
response to oxygen-containing compound
|
AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, HTR5A, IDO1, IGF1R, INSR, MMP2, MMP9, MPO, POLB, PPARA, PRKCB, PRKCD, PRKCE, PTGES, PTGS2, RORC, SRC, TEK, TYR |
16.4002 |
|
[BP] GO:0010647 |
positive regulation of cell communication
|
ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH |
14.3427 |
|
[BP] GO:0023056 |
positive regulation of signaling
|
ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH |
14.325 |
|
[BP] GO:0042127 |
regulation of cell proliferation
|
ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CXCL8, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, IDO1, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH |
12.8823 |
|
[BP] GO:0032879 |
regulation of localization
|
ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, GPR35, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KCNA3, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1B, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK |
12.7317 |
|
[BP] GO:0033993 |
response to lipid
|
ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, IDO1, MPO, PRKCE, PTGES, PTGS2, RORC, SRC, TYR |
12.178 |
|
[BP] GO:0048522 |
positive regulation of cellular process
|
ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
12.178 |
|
[BP] GO:0050896 |
response to stimulus
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, IDO1, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, MPO, NUAK1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR |
11.7873 |
|
[BP] GO:0010646 |
regulation of cell communication
|
ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1B, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH |
11.7647 |
|
[BP] GO:0009967 |
positive regulation of signal transduction
|
ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH |
11.7647 |
|
[BP] GO:0048584 |
positive regulation of response to stimulus
|
ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CXCL8, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH |
11.742 |
|
[BP] GO:1902533 |
positive regulation of intracellular signal transduction
|
ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MET, MIF, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
11.6202 |
|
[BP] GO:0023051 |
regulation of signaling
|
ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1B, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH |
11.6202 |
|
[BP] GO:0006629 |
lipid metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, MIF, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 |
11.6202 |
|
[BP] GO:0042493 |
response to drug
|
ABCB1, ABCG2, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, EGFR, FABP3, HMGCR, HSD11B2, HTR2A, HTR2B, HTR2C, KDR, POLB, PRKCD, PRKCE, PRKCG, PTGS2, SRC |
11.2389 |
|
[BP] GO:0043067 |
regulation of programmed cell death
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, MPO, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH |
11.0767 |
|
[BP] GO:0019369 |
arachidonic acid metabolic process
|
ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS1, PTGS2, TBXAS1 |
11.0767 |
|
[BP] GO:0033559 |
unsaturated fatty acid metabolic process
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS1, PTGS2, TBXAS1 |
11.0767 |
|
[BP] GO:0044281 |
small molecule metabolic process
|
ABCG2, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR2B, HTR2C, IDO1, MIF, MPO, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH |
11.0154 |
|
[BP] GO:0048518 |
positive regulation of biological process
|
ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
10.9298 |
|
[BP] GO:0010941 |
regulation of cell death
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, MPO, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH |
10.9298 |
|
[BP] GO:0006690 |
icosanoid metabolic process
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS1, PTGS2, TBXAS1 |
10.7483 |
|
[BP] GO:0014070 |
response to organic cyclic compound
|
ALPL, APEX1, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, PRKCE, PRKCG, PTGES, PTGS2, RORC, SRC, TEK, TYR |
10.6147 |
|
[BP] GO:0043069 |
negative regulation of programmed cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, MPO, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK |
10.543 |
|
[BP] GO:0060548 |
negative regulation of cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP9, MPO, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK |
10.4339 |
|
[BP] GO:1902531 |
regulation of intracellular signal transduction
|
ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
10.3173 |
|
[BP] GO:0040012 |
regulation of locomotion
|
ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CHRM1, CHRM4, CXCL8, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
10.3173 |
|
[BP] GO:0009719 |
response to endogenous stimulus
|
AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, IGF1R, INSR, KIT, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK |
10.1196 |
|
[BP] GO:0008152 |
metabolic process
|
ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH |
10.0908 |
|
[BP] GO:0042981 |
regulation of apoptotic process
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MIF, MMP9, MPO, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH |
9.89795 |
|
[BP] GO:0048583 |
regulation of response to stimulus
|
ABCB1, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH |
9.89316 |
|
[BP] GO:0032844 |
regulation of homeostatic process
|
ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, DRD1, EGFR, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCE, PTGS2, SRC, TNKS, TNKS2 |
9.88241 |
|
[BP] GO:0032502 |
developmental process
|
ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, MPO, PIM1, POLB, PPARA, PRKCA, PRKCD, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR |
9.7193 |
|
[BP] GO:2000145 |
regulation of cell motility
|
ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CXCL8, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
9.52411 |
|
[BP] GO:0051049 |
regulation of transport
|
ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, DRD1, EGFR, GPR35, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, INSR, KCNA3, MIF, MMP12, MMP9, MTNR1B, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC |
9.44921 |
|
[BP] GO:0006796 |
phosphate-containing compound metabolic process
|
ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH |
9.42999 |
|
[BP] GO:0010817 |
regulation of hormone levels
|
ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, MTNR1B, PRKCA, PRKCE |
9.38982 |
|
[BP] GO:0030334 |
regulation of cell migration
|
ADORA1, ADORA3, APEX1, APP, BCL2, CXCL8, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
9.33054 |
|
[BP] GO:0032501 |
multicellular organismal process
|
ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR7, IDO1, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR |
9.24402 |
|
[BP] GO:0043066 |
negative regulation of apoptotic process
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HMGCR, HSPA1A, HTR2B, IDO1, IGF1R, KDR, MIF, MMP9, MPO, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK |
9.21537 |
|
[BP] GO:0044237 |
cellular metabolic process
|
ABCG2, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP2, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH |
9.20549 |
|
[BP] GO:1903727 |
positive regulation of phospholipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PRKCD, SRC, TEK |
9.08979 |
|
[BP] GO:0010562 |
positive regulation of phosphorus metabolic process
|
ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, EGFR, ESRRB, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, MTNR1A, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
9.08789 |
|
[BP] GO:0045937 |
positive regulation of phosphate metabolic process
|
ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, EGFR, ESRRB, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, MTNR1A, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
9.08789 |
|
[BP] GO:0009725 |
response to hormone
|
AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, INSR, KIT, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK |
9.08789 |
|
[BP] GO:0019216 |
regulation of lipid metabolic process
|
ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, HTR2A, HTR2B, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK |
9.08789 |
|
[BP] GO:0048523 |
negative regulation of cellular process
|
ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, MPO, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
8.99358 |
|
[BP] GO:0080134 |
regulation of response to stress
|
ABCB1, ADORA1, APP, CDK6, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HMGCR, HSPA1A, IDO1, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH |
8.96739 |
|
[BP] GO:0008284 |
positive regulation of cell proliferation
|
AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK |
8.94272 |
|
[BP] GO:0006793 |
phosphorus metabolic process
|
ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, HMGCR, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH |
8.91778 |
|
[BP] GO:0051270 |
regulation of cellular component movement
|
ADORA1, ADORA3, APEX1, APP, BCL2, CDK6, CXCL8, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
8.85732 |
|
[BP] GO:1901568 |
fatty acid derivative metabolic process
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGES, PTGS1, PTGS2, TBXAS1 |
8.8255 |
|
[BP] GO:0045834 |
positive regulation of lipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK |
8.77267 |
|
[BP] GO:0030335 |
positive regulation of cell migration
|
APP, BCL2, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
8.68968 |
|
[BP] GO:0007165 |
signal transduction
|
ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CXCL8, CYP1B1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 |
8.55399 |
|
[BP] GO:0008202 |
steroid metabolic process
|
AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
8.50694 |
|
[BP] GO:0032101 |
regulation of response to external stimulus
|
ADORA1, CNR1, CNR2, CXCL8, CYP19A1, DRD1, EGFR, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MIF, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPRS, SMAD3, TEK |
8.48688 |
|
[BP] GO:0019748 |
secondary metabolic process
|
AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR |
8.48688 |
|
[BP] GO:0001676 |
long-chain fatty acid metabolic process
|
ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS1, PTGS2, TBXAS1 |
8.48688 |
|
[BP] GO:2000147 |
positive regulation of cell motility
|
APP, BCL2, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
8.4683 |
|
[BP] GO:0006468 |
protein phosphorylation
|
APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS |
8.4683 |
|
[BP] GO:0010035 |
response to inorganic substance
|
AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PRKCD, PTGES, PTGS2, SRC |
8.42004 |
|
[BP] GO:0051272 |
positive regulation of cellular component movement
|
APP, BCL2, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
8.28576 |
|
[BP] GO:0048519 |
negative regulation of biological process
|
ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, MPO, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
8.28576 |
|
[BP] GO:0055114 |
oxidation-reduction process
|
AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, PTGS1, PTGS2, TBXAS1, TYR, XDH |
8.12727 |
|
[BP] GO:0071704 |
organic substance metabolic process
|
ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH |
8.09599 |
|
[BP] GO:0040017 |
positive regulation of locomotion
|
APP, BCL2, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
8.05194 |
|
[BP] GO:0007187 |
None
|
ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, HTR1A, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B |
8.03156 |
|
[BP] GO:0007210 |
None
|
HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 |
7.93993 |
|
[BP] GO:0098664 |
None
|
HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 |
7.93993 |
|
[BP] GO:0009628 |
response to abiotic stimulus
|
ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, EGFR, HMGCR, HSD11B2, HSPA1A, HTR2A, HTR2B, KIT, MMP2, MPO, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TYR |
7.90646 |
|
[BP] GO:0019220 |
regulation of phosphate metabolic process
|
ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, MTNR1A, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.82824 |
|
[BP] GO:0042592 |
homeostatic process
|
ABCG2, ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, POLA1, POLB, PRKCB, PRKCE, SMAD3, SRC |
7.81042 |
|
[BP] GO:0043410 |
positive regulation of MAPK cascade
|
ADORA1, ALOX15, APP, EGFR, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH |
7.76975 |
|
[BP] GO:0003018 |
None
|
ADORA1, CHRM1, DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK |
7.756 |
|
[BP] GO:0051174 |
regulation of phosphorus metabolic process
|
ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, MTNR1A, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.75558 |
|
[BP] GO:0009966 |
regulation of signal transduction
|
ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CXCL8, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH |
7.72589 |
|
[BP] GO:0043408 |
regulation of MAPK cascade
|
ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH |
7.72589 |
|
[BP] GO:0051239 |
regulation of multicellular organismal process
|
ADORA1, ADORA3, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CNR1, CXCL8, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IDO1, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH |
7.65985 |
|
[BP] GO:0070887 |
cellular response to chemical stimulus
|
AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC |
7.60061 |
|
[BP] GO:0006631 |
fatty acid metabolic process
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 |
7.57355 |
|
[BP] GO:0071310 |
cellular response to organic substance
|
AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CXCL8, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC |
7.57008 |
|
[BP] GO:0044255 |
cellular lipid metabolic process
|
ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, GBA2, HMGCR, KIT, MET, MIF, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 |
7.56509 |
|
[BP] GO:0032787 |
None
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, MIF, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 |
7.37418 |
|
[BP] GO:0042327 |
positive regulation of phosphorylation
|
ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
7.34835 |
|
[BP] GO:0051173 |
positive regulation of nitrogen compound metabolic process
|
ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
7.34835 |
|
[BP] GO:1903725 |
regulation of phospholipid metabolic process
|
FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PRKCD, SRC, TEK |
7.2789 |
|
[BP] GO:0044238 |
primary metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TYR, XDH |
7.27207 |
|
[BP] GO:0006950 |
response to stress
|
ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, IDO1, KIT, MIF, MMP2, MMP9, MPO, NUAK1, POLA1, POLB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A |
7.23369 |
|
[BP] GO:0070372 |
regulation of ERK1 and ERK2 cascade
|
ALOX15, APP, DUSP3, EGFR, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCA, PTPN1, SRC, TEK |
7.03747 |
|
[BP] GO:0001934 |
positive regulation of protein phosphorylation
|
ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
7.02103 |
|
[BP] GO:0048585 |
negative regulation of response to stimulus
|
ADORA1, ALOX15, BCL2, CDK6, CNR1, CNR2, CXCL8, CYP19A1, DRD1, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH |
6.98043 |
|
[BP] GO:0032845 |
None
|
ADORA1, BCL2, HMGCR, HTR2A, HTR2B, HTR2C, MIF, PRKCE, SRC, TNKS, TNKS2 |
6.98043 |
|
[BP] GO:0008283 |
cell proliferation
|
ABCB1, ACHE, AURKB, BCL2, CHRM1, CHRM4, CYP1A1, EGFR, ESR1, FLT3, HTR1A, KIT, MET, MIF, PIM1, POLA1, PRKCD, SRC, TEK, TYR |
6.89251 |
|
[BP] GO:0042325 |
regulation of phosphorylation
|
ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, ESRRB, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
6.87083 |
|
[BP] GO:0031325 |
positive regulation of cellular metabolic process
|
ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
6.87039 |
|
[BP] GO:0048511 |
rhythmic process
|
AXL, BCL2, CSNK2A1, EGFR, ESR1, HTR7, KIT, MTNR1A, MTNR1B, PPARA, PRKCG, RORC, SRC, TOP2A |
6.86505 |
|
[BP] GO:0009636 |
response to toxic substance
|
AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, HMGCR, KDR, POLB, PRKCD, PRKCE, SRC |
6.75588 |
|
[BP] GO:0016310 |
phosphorylation
|
APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS |
6.74442 |
|
[BP] GO:0046777 |
protein autophosphorylation
|
AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, PRKCG, SRC, TEK |
6.69701 |
|
[BP] GO:0051240 |
positive regulation of multicellular organismal process
|
APP, AXL, BCL2, CA2, CNR1, CXCL8, CYP1B1, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, HTR2A, HTR2B, IDO1, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK |
6.68731 |
|
[BP] GO:0070374 |
positive regulation of ERK1 and ERK2 cascade
|
ALOX15, APP, EGFR, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MIF, PRKCA, SRC, TEK |
6.6781 |
|
[BP] GO:0007610 |
None
|
APP, BCL2, CNR1, DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR2B, HTR2C, IDO1, INSR, KIT, MTNR1A, PPARA, PRKCE, PRKCG, PTGS2 |
6.62542 |
|
[BP] GO:0051716 |
cellular response to stimulus
|
AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A |
6.58102 |
|
[BP] GO:0010243 |
response to organonitrogen compound
|
AKR1B1, APEX1, APP, CNR1, CNR2, DRD1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TYR |
6.57676 |
|
[BP] GO:1901564 |
organonitrogen compound metabolic process
|
ABCG2, ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH |
6.54692 |
|
[BP] GO:0048513 |
animal organ development
|
ACHE, AXL, BCL2, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, POLB, PPARA, PTPRS, SMAD3, SRC, TEK, TYR |
6.50683 |
|
[BP] GO:0003013 |
None
|
ADORA1, CHRM1, DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK |
6.50261 |
|
[BP] GO:0097756 |
None
|
ADORA1, HMGCR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 |
6.50019 |
|
[BP] GO:0097746 |
None
|
ADORA1, CHRM1, DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 |
6.48066 |
|
[BP] GO:0035296 |
None
|
ADORA1, CHRM1, DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 |
6.48066 |
|
[BP] GO:0010648 |
negative regulation of cell communication
|
ACHE, ADORA1, BCL2, CNR2, CXCL8, DRD1, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH |
6.48035 |
|
[BP] GO:0001932 |
regulation of protein phosphorylation
|
ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
6.46821 |
|
[BP] GO:0023057 |
negative regulation of signaling
|
ACHE, ADORA1, BCL2, CNR2, CXCL8, DRD1, DUSP3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH |
6.45702 |
|
[BP] GO:0019371 |
None
|
CBR1, PTGES, PTGS1, PTGS2, TBXAS1 |
6.4535 |
|
[BP] GO:0048878 |
chemical homeostasis
|
ABCG2, AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, MTNR1B, PRKCB, PRKCE, SMAD3 |
6.38523 |
|
[BP] GO:0010604 |
positive regulation of macromolecule metabolic process
|
ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
6.31136 |
|
[BP] GO:0009987 |
cellular process
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNA3, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH |
6.26196 |
|
[BP] GO:0009893 |
positive regulation of metabolic process
|
ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
6.2607 |
|
[BP] GO:0018193 |
peptidyl-amino acid modification
|
AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP2A |
6.25536 |
|
[BP] GO:0050880 |
None
|
ADORA1, CHRM1, DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 |
6.24389 |
|
[BP] GO:0035150 |
None
|
ADORA1, CHRM1, DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 |
6.21474 |
|
[BP] GO:0015701 |
bicarbonate transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
6.15366 |
|
[BP] GO:0002682 |
regulation of immune system process
|
ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CXCL8, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, IDO1, KIT, MIF, MMP12, MMP2, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, PTPRS, SMAD3, SRC |
6.15228 |
|
[BP] GO:0090087 |
None
|
ACHE, ADORA1, APP, CA2, CHRM1, CNR1, EGFR, HCAR2, HMGCR, HTR2B, HTR2C, MIF, MMP12, MTNR1B, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC |
6.13141 |
|
[BP] GO:0065009 |
regulation of molecular function
|
ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CXCL8, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH |
6.08726 |
|
[BP] GO:1901698 |
response to nitrogen compound
|
AKR1B1, APEX1, APP, CNR1, CNR2, DRD1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TYR |
6.05676 |
|
[BP] GO:0050790 |
regulation of catalytic activity
|
ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH |
6.0324 |
|
[BP] GO:0007568 |
aging
|
APEX1, AURKB, BCL2, CNR1, CYP1A1, HMGCR, HTR2A, MIF, MPO, POLB, PRKCD, PTGS2 |
5.98375 |
|
[BP] GO:0065007 |
biological regulation
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNA3, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
5.97489 |
|
[BP] GO:0043405 |
regulation of MAP kinase activity
|
ADORA1, DUSP3, EGFR, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC |
5.97063 |
|
[BP] GO:1901701 |
cellular response to oxygen-containing compound
|
AKR1B1, APEX1, APP, AXL, CDK6, CXCL8, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC |
5.96393 |
|
[BP] GO:0031399 |
regulation of protein modification process
|
ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH |
5.9543 |
|
[BP] GO:0018108 |
peptidyl-tyrosine phosphorylation
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK |
5.94397 |
|
[BP] GO:0006979 |
response to oxidative stress
|
AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, MPO, PRKCD, PTGS1, PTGS2, SRC |
5.93454 |
|
[BP] GO:0043269 |
regulation of ion transport
|
ABCB1, ADORA1, APP, BCL2, CA2, CA7, CHRM1, CNR1, DRD1, GPR35, HTR1A, HTR2A, KCNA3, MIF, MMP9, PRKCD, PRKCE, PTGS2 |
5.91443 |
|
[BP] GO:0018212 |
peptidyl-tyrosine modification
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK |
5.87895 |
|
[BP] GO:0070482 |
response to oxygen levels
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK |
5.86055 |
|
[BP] GO:0050804 |
modulation of chemical synaptic transmission
|
ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1, EGFR, HTR2A, KIT, PRKCE, PTGS2 |
5.69822 |
|
[BP] GO:0099177 |
regulation of trans-synaptic signaling
|
ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1, EGFR, HTR2A, KIT, PRKCE, PTGS2 |
5.69822 |
|
[BP] GO:0048856 |
anatomical structure development
|
ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, INSR, KDR, KIT, MMP9, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR |
5.68336 |
|
[BP] GO:0031347 |
regulation of defense response
|
ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK |
5.67797 |
|
[BP] GO:0051247 |
positive regulation of protein metabolic process
|
ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.6589 |
|
[BP] GO:0006082 |
organic acid metabolic process
|
ABCG2, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, MIF, MPO, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR |
5.59031 |
|
[BP] GO:0032270 |
positive regulation of cellular protein metabolic process
|
ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.58511 |
|
[BP] GO:0032228 |
regulation of synaptic transmission, GABAergic
|
ADORA1, CA2, CA7, CNR1, CNR2, PRKCE |
5.56964 |
|
[BP] GO:0001666 |
response to hypoxia
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK |
5.49315 |
|
[BP] GO:2000021 |
regulation of ion homeostasis
|
ADORA1, BCL2, CA2, CA7, DRD1, HTR2A, HTR2B, HTR2C, KDR, PRKCE, SRC |
5.49017 |
|
[BP] GO:0044092 |
negative regulation of molecular function
|
ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS |
5.44226 |
|
[BP] GO:0046883 |
regulation of hormone secretion
|
ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HMGCR, HTR1A, HTR2A, HTR2C, MTNR1B, PRKCA, PRKCE |
5.42637 |
|
[BP] GO:0007200 |
None
|
CHRM1, CHRM2, CHRM4, DRD1, ESR1, HTR2A, HTR2B, HTR2C |
5.42435 |
|
[BP] GO:0018105 |
peptidyl-serine phosphorylation
|
AURKB, BCL2, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS |
5.41391 |
|
[BP] GO:0036293 |
response to decreased oxygen levels
|
ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK |
5.36074 |
|
[BP] GO:0009894 |
regulation of catabolic process
|
ADORA1, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 |
5.3303 |
|
[BP] GO:0050890 |
None
|
ADORA1, APP, CHRM1, CNR1, DRD1, EGFR, HMGCR, HTR2A, INSR, KIT, PRKCG, PTGS2 |
5.27657 |
|
[BP] GO:0007186 |
G-protein coupled receptor signaling pathway
|
ADORA1, ADORA3, APP, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CXCL8, DRD1, ESR1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, INSR, MTNR1A, MTNR1B, SRC |
5.27359 |
|
[BP] GO:0006730 |
one-carbon metabolic process
|
CA1, CA12, CA2, CA4, CA7, CA9 |
5.27154 |
|
[BP] GO:0046456 |
icosanoid biosynthetic process
|
ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 |
5.2051 |
|
[BP] GO:0032496 |
response to lipopolysaccharide
|
ALPL, AXL, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, IDO1, MPO, PTGES, PTGS2, SRC |
5.20465 |
|
[BP] GO:0031401 |
positive regulation of protein modification process
|
ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MIF, MMP9, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
5.18302 |
|
[BP] GO:0032103 |
positive regulation of response to external stimulus
|
CNR1, CXCL8, EGFR, F3, FABP4, IDO1, KDR, MET, MIF, PRKCA, PTGS2, SMAD3 |
5.17461 |
|
[BP] GO:0035690 |
cellular response to drug
|
AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, PRKCD, PRKCE, PTGS2, SRC |
5.13201 |
|
[BP] GO:0019752 |
carboxylic acid metabolic process
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR |
5.11866 |
|
[BP] GO:0043436 |
oxoacid metabolic process
|
ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, IDO1, MIF, MPO, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR |
5.09526 |
|
[BP] GO:0050730 |
None
|
ADORA1, APP, EGFR, FLT3, HTR2A, KIT, MIF, PRKCD, PRKCE, PTPN1, SRC |
5.07269 |
|
[BP] GO:0001775 |
cell activation
|
ALOX5, APP, AXL, BCL2, CXCL8, EGFR, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, MPO, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC |
5.01509 |
|
[BP] GO:0018209 |
peptidyl-serine modification
|
AURKB, BCL2, DRD1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS |
5.01218 |
|
[BP] GO:0019373 |
epoxygenase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 |
4.99577 |
|
[BP] GO:0042445 |
hormone metabolic process
|
ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.99456 |
|
[BP] GO:0051050 |
positive regulation of transport
|
ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, EGFR, HCAR2, HTR2B, INSR, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC |
4.99456 |
|
[BP] GO:0071073 |
None
|
FABP3, HTR2A, HTR2B, HTR2C |
4.92916 |
|
[BP] GO:0002237 |
response to molecule of bacterial origin
|
ALPL, AXL, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, IDO1, MPO, PTGES, PTGS2, SRC |
4.92674 |
|
[BP] GO:0090066 |
None
|
ADORA1, ALOX15, CHRM1, DRD1, EGFR, HMGCR, HTR1A, HTR2A, HTR2B, HTR7, PRKCD, PRKCE, PTGS2 |
4.76296 |
|
[BP] GO:0034614 |
cellular response to reactive oxygen species
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC |
4.75207 |
|
[BP] GO:0070201 |
None
|
ACHE, APP, BCL2, CHRM1, CNR1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC |
4.73642 |
|
[BP] GO:0051897 |
positive regulation of protein kinase B signaling
|
AXL, EGFR, F10, F3, INSR, KIT, MET, SRC, TEK |
4.69628 |
|
[BP] GO:0050801 |
ion homeostasis
|
ABCG2, APP, BCL2, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
4.6556 |
|
[BP] GO:0009605 |
response to external stimulus
|
ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, EGFR, HMGCR, HSD11B2, HTR2A, IDO1, KIT, MMP12, MPO, PRKCD, PTGES, PTGS2, SMAD3, SRC, TYR |
4.64278 |
|
[BP] GO:0007193 |
None
|
ADORA1, CHRM1, CHRM2, CHRM4, HTR1A, HTR5A, HTR7 |
4.63111 |
|
[BP] GO:0007188 |
None
|
ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, HTR1A, HTR5A, HTR7 |
4.6076 |
|
[BP] GO:0010038 |
response to metal ion
|
ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGES, PTGS2 |
4.59538 |
|
[BP] GO:0002791 |
None
|
ACHE, ADORA1, CNR1, EGFR, HCAR2, HMGCR, HTR2B, HTR2C, MIF, MMP12, MTNR1B, PRKCA, PRKCE, SRC |
4.58354 |
|
[BP] GO:1903530 |
regulation of secretion by cell
|
ACHE, ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HMGCR, HTR1A, HTR2A, HTR2B, HTR2C, MIF, MMP12, MTNR1B, PRKCA, PRKCE, SRC |
4.55113 |
|
[BP] GO:0071495 |
cellular response to endogenous stimulus
|
AKR1B1, APEX1, APP, CXCL8, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, KIT, MMP2, PRKCD, PRKCE, PTGS2, SMAD3, SRC |
4.54402 |
|
[BP] GO:0050727 |
regulation of inflammatory response
|
ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, IDO1, PPARA, PRKCD, PTGS2, SMAD3, TEK |
4.53766 |
|
[BP] GO:0035556 |
intracellular signal transduction
|
AKR1B1, AXL, BCL2, CXCL8, CYP1B1, DRD1, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, KIT, MET, MIF, NUAK1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK |
4.52355 |
|
[BP] GO:0044093 |
positive regulation of molecular function
|
ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MET, MIF, MMP9, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH |
4.5103 |
|
[BP] GO:0051896 |
regulation of protein kinase B signaling
|
AXL, EGFR, F10, F3, INSR, KIT, MET, SRC, TEK, XDH |
4.50731 |
|
[BP] GO:0050793 |
regulation of developmental process
|
APP, AXL, BCL2, CA2, CDK6, CNR1, CXCL8, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, HTR2A, HTR2C, IDO1, INSR, KDR, KIT, MIF, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TNKS2, XDH |
4.46019 |
|
[BP] GO:0051223 |
None
|
ACHE, APP, CHRM1, CNR1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC |
4.4241 |
|
[BP] GO:0050789 |
regulation of biological process
|
ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNA3, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
4.41647 |
|
[BP] GO:0050806 |
positive regulation of synaptic transmission
|
ADORA1, APP, CA2, CA7, DRD1, EGFR, PRKCE, PTGS2 |
4.41568 |
|
[BP] GO:0016572 |
histone phosphorylation
|
AURKB, DRD1, PRKCA, PRKCB, PRKCD |
4.38894 |
|
[BP] GO:0050994 |
None
|
ADORA1, CNR1, HCAR2, PPARA, PRKCD, PRKCE |
4.38597 |
|
[BP] GO:0022414 |
reproductive process
|
AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, INSR, KIT, MMP2, MMP9, MTNR1A, PTGS2, SRC, TOP2A |
4.35252 |
|
[BP] GO:0050794 |
regulation of cellular process
|
ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
4.33047 |
|
[BP] GO:0032102 |
negative regulation of response to external stimulus
|
ADORA1, CNR2, CYP19A1, DRD1, HMGCR, MIF, PPARA, PRKCD, PTPRS, SMAD3, TEK |
4.32938 |
|
[BP] GO:0008610 |
lipid biosynthetic process
|
ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PTGES, PTGS1, PTGS2 |
4.32938 |
|
[BP] GO:0010634 |
positive regulation of epithelial cell migration
|
KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK |
4.32199 |
|
[BP] GO:0051094 |
positive regulation of developmental process
|
APP, AXL, BCL2, CA2, CNR1, CXCL8, CYP1B1, ESRRB, F3, HMGCR, HTR2A, HTR2C, IDO1, INSR, KDR, KIT, PIM1, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK |
4.32199 |
|
[BP] GO:0006636 |
unsaturated fatty acid biosynthetic process
|
ALOX15, MIF, PTGES, PTGS1, PTGS2 |
4.32199 |
|
[BP] GO:0051726 |
regulation of cell cycle
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CXCL8, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TNKS, TOP2A |
4.31062 |
|
[BP] GO:0033555 |
multicellular organismal response to stress
|
BCL2, DRD1, HTR1A, HTR2C, IDO1, PRKCG |
4.3031 |
|
[BP] GO:0051130 |
positive regulation of cellular component organization
|
ALOX15, APP, AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 |
4.28267 |
|
[BP] GO:0032846 |
positive regulation of homeostatic process
|
AURKB, CA2, CA7, CNR1, DRD1, EGFR, HCAR2, PTGS2, TNKS, TNKS2 |
4.27169 |
|
[BP] GO:1901615 |
organic hydroxy compound metabolic process
|
AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, GBA2, HMGCR, HTR1A, TYR |
4.26832 |
|
[BP] GO:0000302 |
response to reactive oxygen species
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC |
4.26832 |
|
[BP] GO:0001516 |
None
|
MIF, PTGES, PTGS1, PTGS2 |
4.26617 |
|
[BP] GO:0046457 |
None
|
MIF, PTGES, PTGS1, PTGS2 |
4.26617 |
|
[BP] GO:0043207 |
response to external biotic stimulus
|
ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PRKCD, PTGES, PTGS2, SMAD3, SRC |
4.25486 |
|
[BP] GO:1904018 |
positive regulation of vasculature development
|
CXCL8, CYP1B1, F3, KDR, KIT, PRKCA, PRKCB, PTGS2, TEK |
4.25439 |
|
[BP] GO:0007198 |
None
|
HTR1A, HTR5A, HTR7 |
4.25439 |
|
[BP] GO:0032847 |
regulation of cellular pH reduction
|
BCL2, CA2, CA7 |
4.25439 |
|
[BP] GO:1901652 |
response to peptide
|
AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK |
4.25401 |
|
[BP] GO:0098771 |
inorganic ion homeostasis
|
ABCG2, APP, BCL2, CA12, CA2, CA7, DRD1, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
4.25401 |
|
[BP] GO:0071407 |
cellular response to organic cyclic compound
|
ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC |
4.22964 |
|
[BP] GO:0007166 |
cell surface receptor signaling pathway
|
ADORA1, ADORA3, APP, AXL, BCL2, CA1, CHRM4, CSNK2A1, CXCL8, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 |
4.19958 |
|
[BP] GO:0080135 |
regulation of cellular response to stress
|
APP, CDK6, DUSP3, EGFR, HMGCR, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, PTPRS, XDH |
4.19671 |
|
[BP] GO:0051046 |
None
|
ACHE, ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HMGCR, HTR1A, HTR2A, HTR2B, HTR2C, MIF, MMP12, MTNR1B, PRKCA, PRKCE, SRC |
4.18286 |
|
[BP] GO:0019222 |
regulation of metabolic process
|
ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
4.15575 |
|
[BP] GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TEK |
4.15072 |
|
[BP] GO:0007611 |
None
|
APP, CNR1, DRD1, EGFR, HMGCR, HTR2A, INSR, KIT, PRKCG, PTGS2 |
4.14508 |
|
[BP] GO:0007346 |
regulation of mitotic cell cycle
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TNKS, TOP2A |
4.11728 |
|
[BP] GO:0071900 |
regulation of protein serine/threonine kinase activity
|
ADORA1, DUSP3, EGFR, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC |
4.11422 |
|
[BP] GO:0051966 |
regulation of synaptic transmission, glutamatergic
|
ADORA1, CNR1, DRD1, EGFR, HTR2A, PTGS2 |
4.10854 |
|
[BP] GO:0051338 |
regulation of transferase activity
|
ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK, TNKS |
4.09479 |
|
[BP] GO:0099536 |
None
|
CHRM1, CHRM2, CHRM4, CNR1, DRD1, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, PRKCG |
4.08628 |
|
[BP] GO:0099537 |
None
|
CHRM1, CHRM2, CHRM4, CNR1, DRD1, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, PRKCG |
4.08628 |
|
[BP] GO:0016477 |
cell migration
|
AXL, CNR2, CXCL8, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK |
4.08224 |
|
[BP] GO:0010863 |
positive regulation of phospholipase C activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
4.07848 |
|
[BP] GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
4.0687 |
|
[BP] GO:0030155 |
regulation of cell adhesion
|
ALOX15, BCL2, CDK6, CXCL8, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK |
4.04665 |
|
[BP] GO:0042446 |
hormone biosynthetic process
|
AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.03353 |
|
[BP] GO:0009607 |
response to biotic stimulus
|
ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CXCL8, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PRKCD, PTGES, PTGS2, SMAD3, SRC |
4.03054 |
|
[BP] GO:0032268 |
regulation of cellular protein metabolic process
|
ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
4.03002 |
|
[BP] GO:0032880 |
regulation of protein localization
|
ACHE, APP, BCL2, CHRM1, CNR1, CSNK2A1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC |
4.02415 |
|
[BP] GO:0009892 |
negative regulation of metabolic process
|
ADORA1, APEX1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HMGCR, HSPA1A, HTR2B, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH |
4.01537 |
|
[BP] GO:1904951 |
positive regulation of establishment of protein localization
|
ACHE, APP, BCL2, CHRM1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC |
4.01537 |
|
[BP] GO:0045787 |
positive regulation of cell cycle
|
APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, PRKCA, PRKCE, SRC |
4.01272 |
|
[BP] GO:1902532 |
negative regulation of intracellular signal transduction
|
BCL2, DUSP3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH |
3.99842 |
|
[BP] GO:0043549 |
regulation of kinase activity
|
ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK |
3.99674 |
|
[BP] GO:0043271 |
negative regulation of ion transport
|
ADORA1, BCL2, CNR1, GPR35, HTR2A, MMP9, PRKCE, PTGS2 |
3.99331 |
|
[BP] GO:0080090 |
regulation of primary metabolic process
|
ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
3.95752 |
|
[BP] GO:0034599 |
cellular response to oxidative stress
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC |
3.93244 |
|
[BP] GO:0050805 |
negative regulation of synaptic transmission
|
ACHE, ADORA1, CNR2, DRD1, HTR2A, PTGS2 |
3.92748 |
|
[BP] GO:0046889 |
None
|
FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 |
3.92748 |
|
[BP] GO:0071071 |
None
|
FABP3, HTR2A, HTR2B, HTR2C |
3.9251 |
|
[BP] GO:0007197 |
None
|
CHRM1, CHRM2, CHRM4 |
3.91353 |
|
[BP] GO:0010513 |
None
|
HTR2A, HTR2B, HTR2C |
3.91353 |
|
[BP] GO:1900274 |
regulation of phospholipase C activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
3.91299 |
|
[BP] GO:0017144 |
drug metabolic process
|
ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD1, EGFR, HSPA1A, IDO1, MPO |
3.9079 |
|
[BP] GO:0045859 |
regulation of protein kinase activity
|
ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC |
3.80007 |
|
[BP] GO:0048869 |
cellular developmental process
|
ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HTR2B, KDR, KIT, MET, MIF, MMP2, MMP9, PRKCD, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A |
3.79183 |
|
[BP] GO:0009891 |
positive regulation of biosynthetic process
|
APP, AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A |
3.78746 |
|
[BP] GO:0045913 |
None
|
ESRRB, HTR2A, INSR, PPARA, PRKCE, SRC |
3.78746 |
|
[BP] GO:0009895 |
negative regulation of catabolic process
|
ADORA1, BCL2, CNR1, EGFR, HCAR2, HTR2B, MET, PPARA, PRKCG, SMAD3 |
3.76023 |
|
[BP] GO:0006464 |
cellular protein modification process
|
ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
3.76023 |
|
[BP] GO:0036211 |
protein modification process
|
ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
3.76023 |
|
[BP] GO:0042180 |
None
|
AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, IDO1 |
3.75657 |
|
[BP] GO:0043406 |
positive regulation of MAP kinase activity
|
ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PTPN1, SRC |
3.75139 |
|
[BP] GO:0042542 |
response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC |
3.74243 |
|
[BP] GO:0034754 |
cellular hormone metabolic process
|
AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 |
3.74243 |
|
[BP] GO:0055080 |
cation homeostasis
|
ABCG2, APP, BCL2, CA2, CA7, DRD1, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
3.74214 |
|
[BP] GO:0045766 |
positive regulation of angiogenesis
|
CXCL8, CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK |
3.74214 |
|
[BP] GO:0003008 |
None
|
ADORA1, AKR1B1, APP, BCL2, CHRM1, CNR1, CNR2, CYP1B1, DRD1, EGFR, HMGCR, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, INSR, KIT, PRKCG, PTGS2, SRC, TEK, TYR |
3.73182 |
|
[BP] GO:0009968 |
negative regulation of signal transduction
|
BCL2, CXCL8, DUSP3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH |
3.71112 |
|
[BP] GO:0030168 |
platelet activation
|
AXL, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC |
3.69553 |
|
[BP] GO:0051701 |
interaction with host
|
AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC |
3.66553 |
|
[BP] GO:0002683 |
negative regulation of immune system process
|
ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, DUSP3, IDO1, MIF, MMP12, PTPRS |
3.65735 |
|
[BP] GO:0051222 |
positive regulation of protein transport
|
ACHE, APP, CHRM1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC |
3.65095 |
|
[BP] GO:0007207 |
None
|
CHRM1, CHRM2, CHRM4 |
3.65095 |
|
[BP] GO:0051054 |
positive regulation of DNA metabolic process
|
AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 |
3.64492 |
|
[BP] GO:0044267 |
cellular protein metabolic process
|
ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
3.61603 |
|
[BP] GO:0001503 |
ossification
|
ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK |
3.60585 |
|
[BP] GO:0030003 |
cellular cation homeostasis
|
ABCG2, APP, BCL2, CA2, CA7, DRD1, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
3.59058 |
|
[BP] GO:0050728 |
negative regulation of inflammatory response
|
ADORA1, CNR2, CYP19A1, PPARA, PRKCD, SMAD3, TEK |
3.58307 |
|
[BP] GO:0048870 |
cell motility
|
AXL, CNR2, CXCL8, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK |
3.58007 |
|
[BP] GO:0043085 |
positive regulation of catalytic activity
|
ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MIF, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TNKS, XDH |
3.5736 |
|
[BP] GO:0072507 |
divalent inorganic cation homeostasis
|
APP, BCL2, DRD1, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
3.54423 |
|
[BP] GO:0048661 |
positive regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2 |
3.54369 |
|
[BP] GO:0040011 |
locomotion
|
AXL, CNR2, CXCL8, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MET, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK |
3.51575 |
|
[BP] GO:0031323 |
regulation of cellular metabolic process
|
ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
3.50255 |
|
[BP] GO:0050708 |
None
|
ACHE, CNR1, EGFR, HCAR2, HMGCR, HTR2B, MIF, MMP12, MTNR1B, PRKCA, PRKCE, SRC |
3.48612 |
|
[BP] GO:0018107 |
peptidyl-threonine phosphorylation
|
BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS |
3.4826 |
|
[BP] GO:0006873 |
cellular ion homeostasis
|
ABCG2, APP, BCL2, CA2, CA7, DRD1, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
3.4826 |
|
[BP] GO:0006952 |
defense response
|
ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, CXCL8, DRD1, HTR1A, HTR2C, KIT, MIF, MPO, POLB, PRKCD, PTGES, PTGS1, PTGS2, SRC |
3.48073 |
|
[BP] GO:2000377 |
regulation of reactive oxygen species metabolic process
|
BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, XDH |
3.47841 |
|
[BP] GO:0097237 |
cellular response to toxic substance
|
AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE |
3.47727 |
|
[BP] GO:0031328 |
positive regulation of cellular biosynthetic process
|
APP, AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A |
3.46174 |
|
[BP] GO:0031348 |
negative regulation of defense response
|
ADORA1, CNR2, CYP19A1, MMP12, PPARA, PRKCD, SMAD3, TEK |
3.44473 |
|
[BP] GO:0009698 |
phenylpropanoid metabolic process
|
CYP1A1, CYP2A13, CYP2A6 |
3.44235 |
|
[BP] GO:0009804 |
coumarin metabolic process
|
CYP1A1, CYP2A13, CYP2A6 |
3.44235 |
|
[BP] GO:0010511 |
None
|
HTR2A, HTR2B, HTR2C |
3.44235 |
|
[BP] GO:1901570 |
None
|
ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 |
3.43252 |
|
[BP] GO:0009991 |
response to extracellular stimulus
|
ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, MPO, PTGS2, SRC, TYR |
3.42038 |
|
[BP] GO:0007167 |
enzyme linked receptor protein signaling pathway
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK |
3.41983 |
|
[BP] GO:0007268 |
None
|
CHRM1, CHRM2, CHRM4, DRD1, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, PRKCG |
3.41883 |
|
[BP] GO:0098916 |
None
|
CHRM1, CHRM2, CHRM4, DRD1, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, PRKCG |
3.41883 |
|
[BP] GO:0043412 |
macromolecule modification
|
ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
3.40924 |
|
[BP] GO:0019538 |
protein metabolic process
|
ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
3.40924 |
|
[BP] GO:0038083 |
peptidyl-tyrosine autophosphorylation
|
EGFR, IGF1R, INSR, KDR, SRC |
3.40341 |
|
[BP] GO:0006954 |
inflammatory response
|
ADORA1, ADORA3, ALOX15, AXL, CNR2, CXCL8, KIT, MIF, POLB, PTGES, PTGS1, PTGS2 |
3.39917 |
|
[BP] GO:0030522 |
intracellular receptor signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC |
3.38787 |
|
[BP] GO:0044070 |
regulation of anion transport
|
ABCB1, ADORA1, CA2, CA7, MIF, PRKCD |
3.38382 |
|
[BP] GO:0044283 |
None
|
AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, HMGCR, IDO1, MIF, MPO, PTGES, PTGS1, PTGS2 |
3.36358 |
|
[BP] GO:0006694 |
steroid biosynthetic process
|
AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.3615 |
|
[BP] GO:0001816 |
cytokine production
|
APP, FABP4, IDO1, KIT, PRKCD, PTGS2 |
3.35659 |
|
[BP] GO:0051347 |
positive regulation of transferase activity
|
ADORA1, AURKB, CDC25B, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK, TNKS |
3.35179 |
|
[BP] GO:0044057 |
None
|
ADORA1, ADORA3, CHRM1, CHRM2, EGFR, GPR35, HCAR2, HTR2A, HTR2C, KIT, PRKCA, PTGS2, SMAD3 |
3.34789 |
|
[BP] GO:0007154 |
None
|
ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM4, CNR1, DRD1, ESR2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, PRKCG, PTGS2, TEK |
3.32984 |
|
[BP] GO:0009611 |
response to wounding
|
ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 |
3.32626 |
|
[BP] GO:0010518 |
positive regulation of phospholipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
3.32626 |
|
[BP] GO:0018210 |
peptidyl-threonine modification
|
BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS |
3.30437 |
|
[BP] GO:0043065 |
positive regulation of apoptotic process
|
BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PRKCD, PTGS2, SMAD3, SRC, TOP2A, XDH |
3.29754 |
|
[BP] GO:0043401 |
steroid hormone mediated signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC |
3.28333 |
|
[BP] GO:0006928 |
movement of cell or subcellular component
|
APP, AXL, CNR2, CXCL8, CYP1B1, DRD1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PRKCA, PRKCD, PTGS2, SRC, TEK, TUBB3 |
3.2789 |
|
[BP] GO:0008210 |
estrogen metabolic process
|
CYP19A1, CYP1B1, HSD17B1, HSD17B2 |
3.2789 |
|
[BP] GO:1903409 |
reactive oxygen species biosynthetic process
|
CYP1A1, CYP1A2, CYP1B1, MPO |
3.2789 |
|
[BP] GO:0019725 |
cellular homeostasis
|
ABCG2, APEX1, APP, BCL2, CA2, CA7, DRD1, ESR1, GPR35, HTR2A, HTR2B, HTR2C, POLA1, PRKCB, PRKCE, SMAD3 |
3.27515 |
|
[BP] GO:0043068 |
positive regulation of programmed cell death
|
BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PRKCD, PTGS2, SMAD3, SRC, TOP2A, XDH |
3.25795 |
|
[BP] GO:0045935 |
positive regulation of nucleobase-containing compound metabolic process
|
APP, AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A |
3.25795 |
|
[BP] GO:0010638 |
positive regulation of organelle organization
|
ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 |
3.24333 |
|
[BP] GO:0051171 |
regulation of nitrogen compound metabolic process
|
ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
3.23852 |
|
[BP] GO:0051246 |
regulation of protein metabolic process
|
ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
3.23333 |
|
[BP] GO:0006874 |
cellular calcium ion homeostasis
|
APP, BCL2, DRD1, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
3.22184 |
|
[BP] GO:0010676 |
None
|
ESRRB, INSR, PPARA, PRKCE, SRC |
3.21789 |
|
[BP] GO:0050927 |
None
|
CXCL8, F3, KDR, SMAD3 |
3.21789 |
|
[BP] GO:0010810 |
regulation of cell-substrate adhesion
|
ALOX15, BCL2, CDK6, KDR, PRKCE, SMAD3, SRC, TEK |
3.19405 |
|
[BP] GO:2000379 |
positive regulation of reactive oxygen species metabolic process
|
EGFR, INSR, PRKCD, PTGS2, SMAD3, XDH |
3.18238 |
|
[BP] GO:0007267 |
None
|
ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, ESR2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, PRKCG, TEK |
3.16872 |
|
[BP] GO:0050926 |
None
|
CXCL8, F3, KDR, SMAD3 |
3.15557 |
|
[BP] GO:0006693 |
None
|
MIF, PTGES, PTGS1, PTGS2 |
3.15557 |
|
[BP] GO:0006692 |
None
|
MIF, PTGES, PTGS1, PTGS2 |
3.15557 |
|
[BP] GO:0055065 |
metal ion homeostasis
|
ABCG2, APP, BCL2, DRD1, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
3.15524 |
|
[BP] GO:0033674 |
positive regulation of kinase activity
|
ADORA1, CDC25B, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK |
3.13211 |
|
[BP] GO:0055074 |
calcium ion homeostasis
|
APP, BCL2, DRD1, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
3.11094 |
|
[BP] GO:0002793 |
None
|
ACHE, ADORA1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC |
3.10413 |
|
[BP] GO:0001101 |
response to acid chemical
|
AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGES, PTGS2, SRC |
3.10222 |
|
[BP] GO:0071417 |
cellular response to organonitrogen compound
|
AKR1B1, APEX1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC |
3.09556 |
|
[BP] GO:0008150 |
biological_process
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNA3, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH |
3.07052 |
|
[BP] GO:0072503 |
cellular divalent inorganic cation homeostasis
|
APP, BCL2, DRD1, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
3.06804 |
|
[BP] GO:0045931 |
positive regulation of mitotic cell cycle
|
APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA |
3.03128 |
|
[BP] GO:0050776 |
regulation of immune response
|
ALOX15, BCL2, CNR1, DUSP3, ESR1, HSPA1A, IDO1, KIT, MIF, MMP12, MMP2, PRKCB, PRKCD, PRKCE, PTPN1, PTPRS, SMAD3, SRC |
3.01961 |
|
[BP] GO:0050678 |
None
|
CDK6, EGFR, F3, HTR2B, KDR, MMP12, PRKCA, SMAD3, TEK, XDH |
3.01961 |
|
[BP] GO:1901342 |
regulation of vasculature development
|
CXCL8, CYP1B1, F3, KDR, KIT, PRKCA, PRKCB, PTGS2, TEK, XDH |
3.00933 |
|
[BP] GO:0031667 |
response to nutrient levels
|
ALPL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, MPO, PTGS2, SRC, TYR |
3.00315 |
|
[BP] GO:0055082 |
cellular chemical homeostasis
|
ABCG2, APP, BCL2, CA2, CA7, DRD1, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
2.98916 |
|
[BP] GO:0006875 |
cellular metal ion homeostasis
|
ABCG2, APP, BCL2, DRD1, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, SMAD3 |
2.98916 |
|
[BP] GO:2001225 |
regulation of chloride transport
|
ABCB1, CA2, CA7 |
2.98735 |
|
[BP] GO:0097267 |
omega-hydroxylase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
2.98735 |
|
[BP] GO:0042310 |
None
|
HTR1A, HTR2A, HTR2B, HTR7 |
2.98525 |
|
[BP] GO:0044089 |
positive regulation of cellular component biogenesis
|
ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK |
2.98525 |
|
[BP] GO:0010517 |
regulation of phospholipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
2.98151 |
|
[BP] GO:0072330 |
monocarboxylic acid biosynthetic process
|
ALOX15, CYP1A1, IDO1, MIF, PTGES, PTGS1, PTGS2 |
2.96907 |
|
[BP] GO:0071248 |
cellular response to metal ion
|
ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.96907 |
|
[BP] GO:0045321 |
leukocyte activation
|
ALOX5, AXL, BCL2, CXCL8, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, MPO, PRKCB, PRKCD, PRKCE, RORC, SMAD3 |
2.96324 |
|
[BP] GO:0060255 |
regulation of macromolecule metabolic process
|
ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HMGCR, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH |
2.96066 |
|
[BP] GO:0043393 |
regulation of protein binding
|
APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC |
2.9595 |
|
[BP] GO:0008217 |
None
|
ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 |
2.95404 |
|
[BP] GO:0010942 |
positive regulation of cell death
|
BCL2, CNR1, CYP1B1, F3, HCAR2, HMGCR, IDO1, MMP9, PRKCD, PTGS2, SMAD3, SRC, TOP2A, XDH |
2.94375 |
|
[BP] GO:0051828 |
entry into other organism involved in symbiotic interaction
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.94224 |
|
[BP] GO:0030260 |
entry into host cell
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.94224 |
|
[BP] GO:0051806 |
entry into cell of other organism involved in symbiotic interaction
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.94224 |
|
[BP] GO:0044409 |
entry into host
|
AXL, EGFR, HSPA1A, HTR2A, MET, SRC |
2.94224 |
|
[BP] GO:0002209 |
None
|
BCL2, DRD1, HTR1A, HTR2C |
2.94224 |
|
[BP] GO:0001662 |
None
|
BCL2, DRD1, HTR1A, HTR2C |
2.94224 |
|
[BP] GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity
|
FLT3, KIT, SRC, TEK |
2.94224 |
|
[BP] GO:0042743 |
hydrogen peroxide metabolic process
|
CYP1A1, CYP1A2, EGFR, MPO |
2.94224 |
|
[BP] GO:0070301 |
cellular response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, CYP1B1, PRKCD |
2.92765 |
|
[BP] GO:0072593 |
reactive oxygen species metabolic process
|
BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MPO |
2.92066 |
|
[BP] GO:0051051 |
negative regulation of transport
|
ADORA1, APP, BCL2, CNR1, GPR35, HMGCR, HSPA1A, HTR2A, MMP9, PRKCB, PRKCE, PTGS2 |
2.91842 |
|
[BP] GO:0051098 |
regulation of binding
|
APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TNKS |
2.90695 |
|
[BP] GO:0031349 |
positive regulation of defense response
|
CNR1, EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PRKCD, PRKCE, PTGS2, SRC |
2.90675 |
|
[BP] GO:0001952 |
regulation of cell-matrix adhesion
|
BCL2, CDK6, KDR, SMAD3, SRC, TEK |
2.90031 |
|
[BP] GO:0060193 |
positive regulation of lipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
2.89866 |
|
[BP] GO:0002320 |
lymphoid progenitor cell differentiation
|
BCL2, FLT3, KIT |
2.88023 |
|
[BP] GO:2000026 |
regulation of multicellular organismal development
|
APP, AXL, BCL2, CA2, CDK6, CNR1, CXCL8, CYP1B1, EGFR, ESR1, ESRRA, F3, HMGCR, IDO1, INSR, KDR, KIT, PIM1, PRKCA, PRKCB, PTGS2, PTPRS, SMAD3, SRC, TEK, XDH |
2.86815 |
|
[BP] GO:0031960 |
response to corticosteroid
|
ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC |
2.86523 |
|
[BP] GO:0043434 |
None
|
APEX1, FABP3, HSD11B2, INSR, PPARA, PRKCD, PTGS2, SRC, TEK |
2.85848 |
|
[BP] GO:0042596 |
None
|
BCL2, DRD1, HTR1A, HTR2C |
2.847 |
|
[BP] GO:0050795 |
None
|
ADORA1, CNR1, HTR1A, HTR2A, HTR2B |
2.847 |
|
[BP] GO:0010811 |
positive regulation of cell-substrate adhesion
|
ALOX15, CDK6, KDR, PRKCE, SMAD3, TEK |
2.847 |
|
[BP] GO:0010632 |
regulation of epithelial cell migration
|
KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK |
2.847 |
|
[BP] GO:0007208 |
None
|
HTR2A, HTR2C |
2.847 |
|
[BP] GO:0035408 |
None
|
PRKCA, PRKCB |
2.847 |
|
[BP] GO:0009115 |
None
|
AOX1, XDH |
2.847 |
|
[BP] GO:0006286 |
base-excision repair, base-free sugar-phosphate removal
|
APEX1, POLB |
2.847 |
|
[BP] GO:0071902 |
positive regulation of protein serine/threonine kinase activity
|
ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PTPN1, SRC |
2.84603 |
|
[BP] GO:0051704 |
multi-organism process
|
APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR2A, IDO1, INSR, KDR, MET, MMP1, MMP12, MPO, POLA1, PRKCD, SMAD3, SRC |
2.84365 |
|
[BP] GO:1901699 |
cellular response to nitrogen compound
|
AKR1B1, APEX1, APP, DRD1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC |
2.83817 |
|
[BP] GO:2001242 |
regulation of intrinsic apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
2.83149 |
|
[BP] GO:0006940 |
None
|
ADORA1, CHRM1, CHRM2, KIT, PTGS2 |
2.82363 |
|
[BP] GO:0031324 |
negative regulation of cellular metabolic process
|
APEX1, APP, AURKB, BCL2, CNR1, CSNK2A1, DUSP3, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH |
2.81899 |
|
[BP] GO:0090218 |
positive regulation of lipid kinase activity
|
FLT3, KIT, SRC, TEK |
2.80976 |
|
[BP] GO:0010907 |
None
|
ESRRB, INSR, PPARA, SRC |
2.80976 |
|
[BP] GO:0048545 |
response to steroid hormone
|
ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC |
2.80276 |
|
[BP] GO:0045860 |
positive regulation of protein kinase activity
|
ADORA1, CDC25B, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MIF, PRKCD, PTPN1, SRC |
2.8024 |
|
[BP] GO:0009416 |
response to light stimulus
|
APP, AURKB, BCL2, DRD1, EGFR, HMGCR, KIT, PTGS2, TYR |
2.80011 |
|
[BP] GO:0003006 |
developmental process involved in reproduction
|
ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, PTGS2, SRC |
2.80011 |
|
[BP] GO:0045759 |
None
|
CNR1, CNR2, GPR35 |
2.78889 |
|
[BP] GO:0031329 |
regulation of cellular catabolic process
|
APEX1, BCL2, CNR1, ESRRB, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 |
2.78508 |
|
[BP] GO:1900076 |
regulation of cellular response to insulin stimulus
|
ESRRA, PRKCB, PRKCD, PTPN1, SRC |
2.77082 |
|
[BP] GO:0051128 |
regulation of cellular component organization
|
ALOX15, APP, AURKB, AXL, BCL2, CNR1, CSNK2A1, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A |
2.74196 |
|
[BP] GO:0023052 |
None
|
ADORA1, CHRM1, CHRM2, CHRM4, CNR1, DRD1, ESR2, HTR2A, HTR2C, HTR6, HTR7, MTNR1B, PRKCG, TEK |
2.74137 |
|
[BP] GO:0033554 |
cellular response to stress
|
AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CXCL8, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, POLA1, POLB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TOP2A |
2.73247 |
|
[BP] GO:0021885 |
forebrain cell migration
|
AXL, DRD1, EGFR, HTR6 |
2.7184 |
|
[BP] GO:0008285 |
negative regulation of cell proliferation
|
ADORA1, ADORA3, APP, BCL2, CDK6, CXCL8, CYP1B1, FABP3, HSPA1A, IDO1, PTGES, PTGS2, SMAD3, XDH |
2.71041 |
|
[BP] GO:0048534 |
hematopoietic or lymphoid organ development
|
BCL2, FLT3, KDR, KIT, POLB, TEK, TYR |
2.6985 |
|
[BP] GO:0009755 |
hormone-mediated signaling pathway
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC |
2.6985 |
|
[BP] GO:0046890 |
None
|
FABP3, HMGCR, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 |
2.6985 |
|
[BP] GO:0006805 |
xenobiotic metabolic process
|
CYP1A1, CYP1A2, CYP1B1, CYP2A13, PTGS1, RORC |
2.69796 |
|
[BP] GO:0006703 |
estrogen biosynthetic process
|
CYP19A1, HSD17B1, HSD17B2 |
2.68934 |
|
[BP] GO:0032230 |
positive regulation of synaptic transmission, GABAergic
|
CA2, CA7, PRKCE |
2.68934 |
|
[BP] GO:1903034 |
regulation of response to wounding
|
F3, HMGCR, PRKCA, PRKCD, PRKCE, PTPRS, SMAD3 |
2.68536 |
|
[BP] GO:0002684 |
positive regulation of immune system process
|
APP, AXL, BCL2, CA2, CNR1, CXCL8, HCAR2, HSPA1A, IDO1, MIF, MMP12, MMP2, PRKCA, PRKCB, PRKCD, PRKCE, SRC |
2.63705 |
|
[BP] GO:0071241 |
cellular response to inorganic substance
|
ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.62553 |
|
[BP] GO:0010564 |
regulation of cell cycle process
|
APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, MIF, PRKCE, TNKS |
2.6169 |
|
[BP] GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation
|
ADORA1, FLT3, HTR2A, KIT, MIF, PTPN1, SRC |
2.61154 |
|
[BP] GO:0050714 |
None
|
ACHE, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC |
2.61154 |
|
[BP] GO:0006109 |
regulation of carbohydrate metabolic process
|
ESRRB, HTR2A, INSR, PPARA, PRKCE, RORC, SRC |
2.59706 |
|
[BP] GO:0060065 |
uterus development
|
CYP19A1, ESR1, SRC |
2.59622 |
|
[BP] GO:0050679 |
None
|
EGFR, F3, HTR2B, KDR, MMP12, PRKCA, TEK |
2.58297 |
|
[BP] GO:0051047 |
None
|
ACHE, ADORA1, CYP19A1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC |
2.57467 |
|
[BP] GO:0010675 |
None
|
ESRRB, INSR, PPARA, PRKCE, RORC, SRC |
2.56714 |
|
[BP] GO:0048609 |
multicellular organismal reproductive process
|
AKR1B1, APP, AXL, CNR1, CYP1A1, DRD1, EGFR, ESR1, KIT, MTNR1A, PTGS2, SRC |
2.54893 |
|
[BP] GO:0032355 |
response to estradiol
|
CYP1A2, EGFR, ESR1, ESRRA, HTR5A, PTGS2 |
2.50957 |
|
[BP] GO:0006720 |
isoprenoid metabolic process
|
AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR |
2.491 |
|
[BP] GO:0050920 |
regulation of chemotaxis
|
CXCL8, CYP19A1, F3, KDR, MET, MIF, SMAD3 |
2.48063 |
|
[BP] GO:0018958 |
None
|
AKR1B1, BCL2, DRD1, HTR1A, TYR |
2.47987 |
|
[BP] GO:1904407 |
positive regulation of nitric oxide metabolic process
|
EGFR, INSR, PTGS2, SMAD3 |
2.46699 |
|
[BP] GO:0045429 |
positive regulation of nitric oxide biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3 |
2.46699 |
|
[BP] GO:0046649 |
lymphocyte activation
|
AXL, BCL2, FLT3, FUT7, KIT, PRKCB, PRKCD, RORC, SMAD3 |
2.44626 |
|
[BP] GO:0048660 |
regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2 |
2.43871 |
|
[BP] GO:0032075 |
None
|
HSPA1A, PRKCD, PTPN1 |
2.42772 |
|
[BP] GO:0007213 |
None
|
CHRM1, CHRM2, CHRM4 |
2.42772 |
|
[BP] GO:0030540 |
female genitalia development
|
AXL, CYP19A1, ESR1 |
2.42772 |
|
[BP] GO:0019372 |
lipoxygenase pathway
|
ALOX15, ALOX5, PTGS2 |
2.42772 |
|
[BP] GO:0098502 |
DNA dephosphorylation
|
APEX1, POLB |
2.42772 |
|
[BP] GO:0046110 |
None
|
AOX1, XDH |
2.42772 |
|
[BP] GO:0032849 |
positive regulation of cellular pH reduction
|
CA2, CA7 |
2.42772 |
|
[BP] GO:0050878 |
regulation of body fluid levels
|
ADORA1, AKR1B1, CHRM1, F10, F3, MET, PRKCA, PRKCD, PRKCE, XDH |
2.42665 |
|
[BP] GO:0006807 |
nitrogen compound metabolic process
|
ABCG2, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, HTR1A, HTR2B, HTR2C, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH |
2.41771 |
|
[BP] GO:1900182 |
positive regulation of protein localization to nucleus
|
APP, EGFR, PRKCD, PTGS2, SMAD3, SRC |
2.41243 |
|
[BP] GO:0009056 |
catabolic process
|
ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, SRC, XDH |
2.40445 |
|
[BP] GO:0043551 |
regulation of phosphatidylinositol 3-kinase activity
|
FLT3, KIT, SRC, TEK |
2.39898 |
|
[BP] GO:2000106 |
regulation of leukocyte apoptotic process
|
AURKB, AXL, HCAR2, IDO1, MIF |
2.39347 |
|
[BP] GO:0033273 |
response to vitamin
|
ALPL, CYP1A1, EGFR, PTGS2, TYR |
2.39347 |
|
[BP] GO:0001505 |
regulation of neurotransmitter levels
|
ACHE, CYP1B1, DRD1, EGFR, HTR1A, INSR, PTGS2, SMAD3 |
2.39031 |
|
[BP] GO:0050999 |
None
|
CNR1, CNR2, EGFR, HTR2B |
2.36393 |
|
[BP] GO:0001936 |
None
|
F3, HTR2B, KDR, PRKCA, TEK, XDH |
2.36393 |
|
[BP] GO:0008631 |
intrinsic apoptotic signaling pathway in response to oxidative stress
|
BCL2, CYP1B1, PRKCD |
2.35916 |
|
[BP] GO:1904355 |
positive regulation of telomere capping
|
AURKB, TNKS, TNKS2 |
2.35916 |
|
[BP] GO:0007584 |
response to nutrient
|
ALPL, CNR1, CYP1A1, EGFR, HMGCR, PTGS2, TYR |
2.34558 |
|
[BP] GO:0001954 |
positive regulation of cell-matrix adhesion
|
CDK6, KDR, SMAD3, TEK |
2.33084 |
|
[BP] GO:0051283 |
None
|
HTR2A, HTR2B, HTR2C, PRKCE |
2.33084 |
|
[BP] GO:0051209 |
None
|
HTR2A, HTR2B, HTR2C, PRKCE |
2.33084 |
|
[BP] GO:0002521 |
leukocyte differentiation
|
AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC |
2.32998 |
|
[BP] GO:0060191 |
regulation of lipase activity
|
EGFR, ESR1, HTR2A, HTR2B, KIT |
2.32998 |
|
[BP] GO:0010595 |
positive regulation of endothelial cell migration
|
KDR, MET, PRKCA, PTGS2, TEK |
2.32998 |
|
[BP] GO:0007623 |
circadian rhythm
|
EGFR, HTR7, MTNR1A, MTNR1B, PPARA, RORC |
2.31971 |
|
[BP] GO:0007612 |
None
|
APP, DRD1, HMGCR, INSR, KIT, PTGS2 |
2.31971 |
|
[BP] GO:0006633 |
None
|
ALOX15, MIF, PTGES, PTGS1, PTGS2 |
2.3089 |
|
[BP] GO:0001938 |
None
|
F3, HTR2B, KDR, PRKCA, TEK |
2.3089 |
|
[BP] GO:0016137 |
None
|
AKR1B1, AKR1B10, GBA2 |
2.29225 |
|
[BP] GO:0045821 |
None
|
ESRRB, HTR2A, INSR |
2.29225 |
|
[BP] GO:0015711 |
organic anion transport
|
ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA |
2.29141 |
|
[BP] GO:0046394 |
None
|
ALOX15, ALOX5, CYP1A1, IDO1, MIF, PTGES, PTGS1, PTGS2 |
2.28044 |
|
[BP] GO:0051384 |
response to glucocorticoid
|
ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 |
2.27369 |
|
[BP] GO:0016053 |
None
|
ALOX15, ALOX5, CYP1A1, IDO1, MIF, PTGES, PTGS1, PTGS2 |
2.27073 |
|
[BP] GO:2000107 |
negative regulation of leukocyte apoptotic process
|
AURKB, AXL, IDO1, MIF |
2.26834 |
|
[BP] GO:0051172 |
None
|
APEX1, APP, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HMGCR, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH |
2.26733 |
|
[BP] GO:0009314 |
response to radiation
|
APP, AURKB, BCL2, DRD1, EGFR, HMGCR, KIT, POLB, PTGS2, TYR |
2.26293 |
|
[BP] GO:0032870 |
cellular response to hormone stimulus
|
APEX1, EGFR, ESR1, FLT3, INSR, KIT, PRKCD, PRKCE, SRC |
2.25584 |
|
[BP] GO:0048608 |
reproductive structure development
|
AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC |
2.2426 |
|
[BP] GO:0016042 |
lipid catabolic process
|
ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 |
2.2426 |
|
[BP] GO:0090276 |
None
|
CNR1, EGFR, HMGCR, HTR2C, MTNR1B, PRKCA, PRKCE |
2.24151 |
|
[BP] GO:0008542 |
None
|
APP, DRD1, HMGCR, KIT |
2.23828 |
|
[BP] GO:0006939 |
None
|
DRD1, HTR2A, HTR2B, HTR7 |
2.23828 |
|
[BP] GO:0051900 |
regulation of mitochondrial depolarization
|
BCL2, KDR, SRC |
2.2318 |
|
[BP] GO:0007617 |
None
|
APP, DRD1, MTNR1A |
2.2318 |
|
[BP] GO:0051197 |
None
|
ESRRB, HTR2A, INSR |
2.2318 |
|
[BP] GO:0050877 |
None
|
ADORA1, APP, CHRM1, CNR1, CNR2, CYP1B1, DRD1, EGFR, HMGCR, HTR2A, INSR, KIT, PRKCG, PTGS2, TYR |
2.22391 |
|
[BP] GO:0061041 |
regulation of wound healing
|
F3, HMGCR, PRKCA, PRKCD, PRKCE, SMAD3 |
2.21871 |
|
[BP] GO:0046626 |
regulation of insulin receptor signaling pathway
|
PRKCB, PRKCD, PTPN1, SRC |
2.20893 |
|
[BP] GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process
|
CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH |
2.19697 |
|
[BP] GO:0050900 |
leukocyte migration
|
CNR2, CXCL8, FUT7, KIT, MIF, MMP1, MMP9, SRC, TEK |
2.19179 |
|
[BP] GO:0009410 |
None
|
CNR1, CNR2, DRD1, EGFR, PRKCE, PRKCG |
2.17403 |
|
[BP] GO:1901653 |
cellular response to peptide
|
AKR1B1, APEX1, APP, IGF1R, INSR, PRKCD, SRC |
2.17403 |
|
[BP] GO:0070213 |
None
|
TNKS, TNKS2 |
2.17392 |
|
[BP] GO:0006145 |
None
|
AOX1, XDH |
2.17392 |
|
[BP] GO:0038171 |
None
|
CNR1, CNR2 |
2.17392 |
|
[BP] GO:0018894 |
dibenzo-p-dioxin metabolic process
|
CYP1A1, CYP1A2 |
2.17392 |
|
[BP] GO:1903532 |
None
|
ACHE, CYP19A1, EGFR, HCAR2, HTR2B, MIF, MMP12, PRKCE, SRC |
2.15452 |
|
[BP] GO:0071396 |
cellular response to lipid
|
AXL, CDK6, CXCL8, EGFR, ESR1, FLT3, PRKCE, RORC, SRC |
2.15452 |
|
[BP] GO:2001234 |
negative regulation of apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
2.14291 |
|
[BP] GO:0002009 |
morphogenesis of an epithelium
|
BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC |
2.13311 |
|
[BP] GO:1903428 |
positive regulation of reactive oxygen species biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3 |
2.12081 |
|
[BP] GO:0043550 |
regulation of lipid kinase activity
|
FLT3, KIT, SRC, TEK |
2.12081 |
|
[BP] GO:0010906 |
None
|
ESRRB, INSR, PPARA, RORC, SRC |
2.11714 |
|
[BP] GO:0071498 |
cellular response to fluid shear stress
|
CA2, PTGS2, SRC |
2.11714 |
|
[BP] GO:0032094 |
None
|
CYP1A1, HSD11B2, MPO |
2.11714 |
|
[BP] GO:0051968 |
None
|
DRD1, EGFR, PTGS2 |
2.11714 |
|
[BP] GO:0016311 |
None
|
ALPL, APEX1, BCL2, CDC25B, DUSP3, POLB, PTPN1, PTPRS |
2.11714 |
|
[BP] GO:0051480 |
regulation of cytosolic calcium ion concentration
|
DRD1, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCE, SMAD3 |
2.10749 |
|
[BP] GO:0009896 |
positive regulation of catabolic process
|
CSNK2A1, ESRRB, HSPA1A, HTR2A, INSR, KDR, PPARA, PRKCD, PRKCE, PTPN1 |
2.1047 |
|
[BP] GO:0032872 |
regulation of stress-activated MAPK cascade
|
APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH |
2.10064 |
|
[BP] GO:0014066 |
regulation of phosphatidylinositol 3-kinase signaling
|
EGFR, FLT3, KDR, KIT, TEK |
2.10012 |
|
[BP] GO:0007632 |
None
|
APP, DRD1, HMGCR, KIT |
2.09685 |
|
[BP] GO:0048146 |
positive regulation of fibroblast proliferation
|
CDK6, EGFR, ESR1, MIF |
2.09685 |
|
[BP] GO:0032210 |
regulation of telomere maintenance via telomerase
|
AURKB, SRC, TNKS, TNKS2 |
2.09685 |
|
[BP] GO:0070302 |
regulation of stress-activated protein kinase signaling cascade
|
APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH |
2.09175 |
|
[BP] GO:0042307 |
positive regulation of protein import into nucleus
|
APP, EGFR, PRKCD, PTGS2, SMAD3 |
2.0834 |
|
[BP] GO:0042752 |
None
|
ADORA1, PPARA, PRKCG, RORC, TOP2A |
2.0834 |
|
[BP] GO:0051893 |
regulation of focal adhesion assembly
|
KDR, SMAD3, SRC, TEK |
2.0687 |
|
[BP] GO:0090109 |
regulation of cell-substrate junction assembly
|
KDR, SMAD3, SRC, TEK |
2.0687 |
|
[BP] GO:0033138 |
positive regulation of peptidyl-serine phosphorylation
|
APP, BCL2, EGFR, MIF, PTGS2 |
2.06783 |
|
[BP] GO:0022612 |
gland morphogenesis
|
BCL2, EGFR, POLB |
2.06783 |
|
[BP] GO:0051194 |
None
|
ESRRB, HTR2A, INSR |
2.06783 |
|
[BP] GO:0030520 |
intracellular estrogen receptor signaling pathway
|
ESR1, ESR2, SRC |
2.06783 |
|
[BP] GO:0050995 |
None
|
ADORA1, CNR1, HCAR2 |
2.06783 |
|
[BP] GO:0050996 |
None
|
PPARA, PRKCD, PRKCE |
2.06783 |
|
[BP] GO:1904591 |
positive regulation of protein import
|
APP, EGFR, PRKCD, PTGS2, SMAD3 |
2.04857 |
|
[BP] GO:0051248 |
None
|
APP, CSNK2A1, DUSP3, EGFR, FABP4, HMGCR, HSPA1A, IGF1R, MIF, MMP9, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, XDH |
2.04731 |
|
[BP] GO:0048565 |
None
|
CXCL8, CYP1A1, EGFR, KIT |
2.04449 |
|
[BP] GO:0032768 |
None
|
CNR1, CNR2, EGFR, HTR2B |
2.04449 |
|
[BP] GO:0046686 |
response to cadmium ion
|
CYP1A2, EGFR, KIT, MMP9 |
2.01486 |
|
[BP] GO:0095500 |
None
|
CHRM1, CHRM2, CHRM4 |
2.01423 |
|
[BP] GO:0009404 |
toxin metabolic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.01423 |
|
[BP] GO:1903831 |
None
|
CHRM1, CHRM2, CHRM4 |
2.01423 |
|
[BP] GO:0045765 |
regulation of angiogenesis
|
CXCL8, CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK |
2.00429 |
|
[CC] GO:0005886 |
plasma membrane
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, DRD1, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, KIT, MET, MMP2, MTNR1A, MTNR1B, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SMAD3, SRC, TEK |
7.98714 |
|
[CC] GO:0044459 |
plasma membrane part
|
ABCB1, ABCG2, ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, KIT, MET, MTNR1A, MTNR1B, PRKCG, PTGS2, PTPRS, SRC, TEK |
7.46952 |
|
[CC] GO:0031226 |
intrinsic component of plasma membrane
|
ADORA1, ADORA3, APP, AXL, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PTPRS, TEK |
7.10039 |
|
[CC] GO:0016020 |
membrane
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, KIT, MET, MMP2, MTNR1A, MTNR1B, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR |
7.10039 |
|
[CC] GO:0005887 |
integral component of plasma membrane
|
ADORA1, ADORA3, APP, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PTPRS, TEK |
5.72608 |
|
[CC] GO:0044425 |
membrane part
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, KIT, MET, MTNR1A, MTNR1B, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TEK, TYR |
5.26405 |
|
[CC] GO:0044464 |
cell part
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNA3, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH |
3.78746 |
|
[CC] GO:0098590 |
plasma membrane region
|
ABCB1, ABCG2, ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, DRD1, EGFR, HTR2A, INSR, MET, PRKCG, PTGS2, SRC, TEK |
3.7639 |
|
[CC] GO:0044432 |
endoplasmic reticulum part
|
APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, EGFR, F10, FLT3, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGES, PTGS1, PTGS2, PTPN1, TBXAS1 |
3.69142 |
|
[CC] GO:0048471 |
perinuclear region of cytoplasm
|
ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, PTGES, SRC, TNKS2, TYR |
3.61045 |
|
[CC] GO:0005789 |
endoplasmic reticulum membrane
|
BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, EGFR, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGES, PTGS1, PTGS2, TBXAS1 |
3.57475 |
|
[CC] GO:0005783 |
None
|
ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, GBA2, HMGCR, HSPA1A, HTR5A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH |
3.44473 |
|
[CC] GO:0045121 |
membrane raft
|
APP, CNR1, EGFR, HTR2A, INSR, KCNA3, KDR, PTGS2, SRC, TEK |
3.40924 |
|
[CC] GO:0098857 |
membrane microdomain
|
APP, CNR1, EGFR, HTR2A, INSR, KCNA3, KDR, PTGS2, SRC, TEK |
3.38787 |
|
[CC] GO:0005641 |
nuclear envelope lumen
|
ALOX5, APP, PTGES |
3.27364 |
|
[CC] GO:0043005 |
None
|
ADORA1, APP, CA2, CHRM1, CHRM2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, KCNA3, PRKCG, PTGS2, PTPRS, SRC, TUBB3 |
3.23488 |
|
[CC] GO:0120025 |
None
|
ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, DRD1, HTR2A, HTR2B, HTR5A, HTR6, KCNA3, PRKCG, PTGS2, PTPRS, SRC, TEK, TUBB3 |
3.14342 |
|
[CC] GO:0044444 |
cytoplasmic part
|
ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR5A, IDO1, INSR, KDR, KIT, MIF, MMP2, MMP9, MPO, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH |
2.99372 |
|
[CC] GO:0042995 |
cell projection
|
ADORA1, AKR1B1, APP, CA2, CDK6, CHRM1, CHRM2, CNR1, CNR2, DRD1, HTR2A, HTR2B, HTR5A, HTR6, KCNA3, PRKCG, PTGS2, PTPRS, SRC, TEK, TUBB3 |
2.84603 |
|
[CC] GO:0031224 |
None
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, KIT, MET, MTNR1A, MTNR1B, PTGES, PTPRS, TBXAS1, TEK, TYR |
2.84603 |
|
[CC] GO:0098589 |
membrane region
|
APP, CNR1, EGFR, HTR2A, INSR, KCNA3, KDR, PTGS2, SRC, TEK |
2.81934 |
|
[CC] GO:0016021 |
None
|
ABCB1, ABCG2, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GPR35, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KCNA3, KDR, KIT, MET, MTNR1A, MTNR1B, PTGES, PTPRS, TBXAS1, TEK, TYR |
2.18757 |
|
[CC] GO:0031233 |
None
|
CA4, F10, F3 |
2.17392 |
|
[MF] GO:0043167 |
ion binding
|
ABCB1, ABCG2, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH |
17.0765 |
|
[MF] GO:0046914 |
transition metal ion binding
|
ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH |
15.4643 |
|
[MF] GO:0003824 |
catalytic activity
|
ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH |
15.4319 |
|
[MF] GO:0043169 |
cation binding
|
ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH |
11.4932 |
|
[MF] GO:0099528 |
None
|
CHRM1, CHRM2, CHRM4, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 |
11.0767 |
|
[MF] GO:0038023 |
signaling receptor activity
|
ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK |
10.9298 |
|
[MF] GO:0008144 |
drug binding
|
ABCB1, ABCG2, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD1, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A |
10.3173 |
|
[MF] GO:0060089 |
molecular transducer activity
|
ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK |
9.88241 |
|
[MF] GO:0016491 |
oxidoreductase activity
|
AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, MPO, PTGS1, PTGS2, TBXAS1, TYR, XDH |
9.8037 |
|
[MF] GO:0004871 |
signal transducer activity
|
ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, PRKCE, RORC, SMAD3, TEK |
9.77463 |
|
[MF] GO:0004872 |
receptor activity
|
ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK |
9.5878 |
|
[MF] GO:0008227 |
None
|
CHRM1, CHRM2, CHRM4, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 |
9.44921 |
|
[MF] GO:0004089 |
carbonate dehydratase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
9.38982 |
|
[MF] GO:0020037 |
heme binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS1, PTGS2, SRC, TBXAS1 |
8.57795 |
|
[MF] GO:0043176 |
None
|
HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 |
8.43758 |
|
[MF] GO:0051378 |
None
|
HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 |
8.43758 |
|
[MF] GO:0046906 |
tetrapyrrole binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS1, PTGS2, SRC, TBXAS1 |
8.26215 |
|
[MF] GO:0030594 |
None
|
CHRM1, CHRM2, CHRM4, DRD1, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 |
8.12616 |
|
[MF] GO:0048037 |
cofactor binding
|
AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B2, HSD17B1, IDO1, MPO, POLA1, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH |
8.11874 |
|
[MF] GO:0099600 |
transmembrane receptor activity
|
ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, TEK |
7.93993 |
|
[MF] GO:0004888 |
transmembrane signaling receptor activity
|
ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, MTNR1A, MTNR1B, TEK |
7.93993 |
|
[MF] GO:0004993 |
None
|
HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 |
7.93993 |
|
[MF] GO:0099589 |
None
|
HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7 |
7.93993 |
|
[MF] GO:0004714 |
transmembrane receptor protein tyrosine kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK |
7.81042 |
|
[MF] GO:0046872 |
metal ion binding
|
ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH |
7.6814 |
|
[MF] GO:0008270 |
zinc ion binding
|
CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS |
7.53592 |
|
[MF] GO:0016835 |
carbon-oxygen lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB |
7.12697 |
|
[MF] GO:0019199 |
transmembrane receptor protein kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK |
6.94509 |
|
[MF] GO:0004672 |
protein kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK |
6.90064 |
|
[MF] GO:0005506 |
iron ion binding
|
ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH |
6.54403 |
|
[MF] GO:0016614 |
oxidoreductase activity, acting on CH-OH group of donors
|
AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH |
6.13141 |
|
[MF] GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 |
6.08458 |
|
[MF] GO:0004713 |
protein tyrosine kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK |
6.04726 |
|
[MF] GO:0070405 |
ammonium ion binding
|
ACHE, DRD1, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 |
5.97063 |
|
[MF] GO:0097159 |
organic cyclic compound binding
|
ABCB1, ABCG2, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MPO, MTNR1A, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TUBB3, XDH |
5.82684 |
|
[MF] GO:0016773 |
phosphotransferase activity, alcohol group as acceptor
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK |
5.69822 |
|
[MF] GO:0042165 |
neurotransmitter binding
|
ACHE, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 |
5.68997 |
|
[MF] GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TBXAS1, TYR |
5.64831 |
|
[MF] GO:0004697 |
None
|
PRKCA, PRKCB, PRKCD, PRKCE, PRKCG |
5.58691 |
|
[MF] GO:0016836 |
hydro-lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
5.53575 |
|
[MF] GO:0016772 |
transferase activity, transferring phosphorus-containing groups
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, POLB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK |
5.26787 |
|
[MF] GO:0043168 |
anion binding
|
ABCB1, ABCG2, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MPO, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPRS, SRC, TEK, TOP2A, TUBB3, XDH |
5.24463 |
|
[MF] GO:0004497 |
monooxygenase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR |
5.15211 |
|
[MF] GO:1901363 |
heterocyclic compound binding
|
ABCB1, ABCG2, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TUBB3, XDH |
5.14145 |
|
[MF] GO:0016301 |
kinase activity
|
AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK |
5.13201 |
|
[MF] GO:0016829 |
lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB |
5.01218 |
|
[MF] GO:0004716 |
signal transducer, downstream of receptor, with protein tyrosine kinase activity
|
EGFR, INSR, KDR, KIT |
4.92916 |
|
[MF] GO:0070330 |
aromatase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 |
4.79281 |
|
[MF] GO:0019899 |
enzyme binding
|
APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HMGCR, HSPA1A, KIT, MET, MIF, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A |
4.55113 |
|
[MF] GO:0098531 |
transcription factor activity, direct ligand regulated sequence-specific DNA binding
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC |
4.52071 |
|
[MF] GO:0004879 |
nuclear receptor activity
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC |
4.52071 |
|
[MF] GO:0036094 |
small molecule binding
|
ABCB1, ABCG2, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TUBB3, XDH |
4.50731 |
|
[MF] GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
4.46097 |
|
[MF] GO:0000166 |
nucleotide binding
|
ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TUBB3, XDH |
4.4324 |
|
[MF] GO:1901265 |
nucleoside phosphate binding
|
ABCB1, ABCG2, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HMGCR, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TUBB3, XDH |
4.42958 |
|
[MF] GO:0004930 |
None
|
ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, DRD1, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B |
4.41372 |
|
[MF] GO:0005496 |
steroid binding
|
ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC |
4.31444 |
|
[MF] GO:0004698 |
None
|
PRKCA, PRKCB, PRKCG |
4.25439 |
|
[MF] GO:0003707 |
steroid hormone receptor activity
|
ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC |
4.10854 |
|
[MF] GO:0016907 |
None
|
CHRM1, CHRM2, CHRM4 |
3.91353 |
|
[MF] GO:0005524 |
ATP binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A |
3.80771 |
|
[MF] GO:0097367 |
carbohydrate derivative binding
|
ABCB1, ABCG2, ADORA1, APP, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MPO, NUAK1, PIM1, POLA1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPRS, SRC, TEK, TOP2A, TUBB3 |
3.75152 |
|
[MF] GO:0032559 |
adenyl ribonucleotide binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A |
3.65977 |
|
[MF] GO:0030554 |
adenyl nucleotide binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A |
3.61663 |
|
[MF] GO:0019825 |
oxygen binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 |
3.47853 |
|
[MF] GO:0042562 |
hormone binding
|
ACHE, EGFR, HSD17B1, IGF1R, INSR, MTNR1A |
3.30437 |
|
[MF] GO:0032403 |
protein complex binding
|
ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC |
3.23488 |
|
[MF] GO:0044877 |
macromolecular complex binding
|
ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC |
3.21161 |
|
[MF] GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
ALOX15, ALOX5, IDO1, PTGS2 |
3.15557 |
|
[MF] GO:0033764 |
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
3.09602 |
|
[MF] GO:0016701 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
|
ALOX15, ALOX5, IDO1, PTGS2 |
3.09602 |
|
[MF] GO:0003674 |
molecular_function
|
ABCB1, ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR2C, HTR5A, HTR6, HTR7, IDO1, IGF1R, INSR, KCNA3, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, MPO, MTNR1A, MTNR1B, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH |
3.06804 |
|
[MF] GO:0016229 |
steroid dehydrogenase activity
|
HSD11B1, HSD11B2, HSD17B1, HSD17B2 |
2.98525 |
|
[MF] GO:0035639 |
purine ribonucleoside triphosphate binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TUBB3 |
2.94224 |
|
[MF] GO:0140096 |
catalytic activity, acting on a protein
|
AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, PTPRS, SRC, TEK |
2.94224 |
|
[MF] GO:0043560 |
insulin receptor substrate binding
|
IGF1R, INSR, PRKCD |
2.88023 |
|
[MF] GO:0009931 |
None
|
PRKCA, PRKCB, PRKCG |
2.88023 |
|
[MF] GO:0008289 |
lipid binding
|
ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC |
2.85848 |
|
[MF] GO:0004666 |
prostaglandin-endoperoxide synthase activity
|
PTGS1, PTGS2 |
2.847 |
|
[MF] GO:0038052 |
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
|
ESR1, ESR2 |
2.847 |
|
[MF] GO:0003845 |
None
|
HSD11B1, HSD11B2 |
2.847 |
|
[MF] GO:0008389 |
None
|
CYP2A13, CYP2A6 |
2.847 |
|
[MF] GO:0035403 |
None
|
PRKCA, PRKCB |
2.847 |
|
[MF] GO:0071886 |
None
|
HTR2A, HTR2C |
2.847 |
|
[MF] GO:0009055 |
electron transfer activity
|
AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH |
2.81235 |
|
[MF] GO:0010857 |
None
|
PRKCA, PRKCB, PRKCG |
2.78889 |
|
[MF] GO:0008395 |
steroid hydroxylase activity
|
CYP19A1, CYP1A1, CYP2A13, CYP2A6 |
2.76499 |
|
[MF] GO:0019902 |
phosphatase binding
|
BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 |
2.74196 |
|
[MF] GO:0032555 |
purine ribonucleotide binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TUBB3 |
2.68448 |
|
[MF] GO:0017076 |
purine nucleotide binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TUBB3 |
2.66025 |
|
[MF] GO:0032553 |
ribonucleotide binding
|
ABCB1, ABCG2, AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TUBB3 |
2.65442 |
|
[MF] GO:0004674 |
protein serine/threonine kinase activity
|
AURKB, CDK6, CSNK2A1, EGFR, NUAK1, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG |
2.64311 |
|
[MF] GO:0008502 |
None
|
MTNR1A, MTNR1B |
2.42772 |
|
[MF] GO:0050473 |
arachidonate 15-lipoxygenase activity
|
ALOX15, PTGS2 |
2.42772 |
|
[MF] GO:0004949 |
None
|
CNR1, CNR2 |
2.42772 |
|
[MF] GO:0004699 |
None
|
PRKCD, PRKCE |
2.42772 |
|
[MF] GO:0016903 |
None
|
AKR1B1, AKR1B10, AOX1, XDH |
2.36393 |
|
[MF] GO:0035173 |
histone kinase activity
|
AURKB, PRKCA, PRKCB |
2.35916 |
|
[MF] GO:0015464 |
None
|
CHRM1, CHRM2, CHRM4 |
2.29225 |
|
[MF] GO:0035258 |
None
|
ESR1, FLT3, PRKCB, SMAD3, SRC |
2.26834 |
|
[MF] GO:0051213 |
dioxygenase activity
|
ALOX15, ALOX5, IDO1, PTGS1, PTGS2 |
2.231 |
|
[MF] GO:0042802 |
identical protein binding
|
ABCG2, ACHE, AOX1, APP, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MIF, MMP9, PTGS2, SMAD3, TOP2A, TYR, XDH |
2.21112 |
|
[MF] GO:0034056 |
estrogen response element binding
|
ESR1, ESR2 |
2.17392 |
|
[MF] GO:0051425 |
None
|
APP, INSR |
2.17392 |
