TCM Prescription: Guan Jie Zhen Tong Ointment



Prescription Description
Prescription IDTCMF3703
Pinyin NameGuan Jie Zhen Tong Gao
Chinese Name关节镇痛膏
English NameGuan Jie Zhen Tong Ointment
Function Description痹病, 跌打损伤
IndicationsArthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1228 Capsicum frutescens 辣椒 TCMH1228 ITSAL4555-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH1063 Curcuma longa 姜黄 TCMH1063 ITSAP2805-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1693 Aristolochia debilis 青木香 TCMH1693 GBVE1975-11
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH296 Radix aconiti 川乌 TCMH296
TCMH189 Mentholum 薄荷脑 TCMH189
TCMH2009 Methyl salicylatum 水杨酸甲酯 TCMH2009
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
TCMH472 Atropa belladonna 颠茄流浸膏 TCMH472 AY028147
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT962 ENPP2 Autotaxin Hydrolase Q13822


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD3, EGFR, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MET, MIF, POLA1, POLB, PPARA, PRKCD, SMAD3, SRC, TEK, TRPV1, XDH 11.6113
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, KIT, MET, MIF, PPARA, PTGES, TBXAS1, TRPV1 11.6113
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TRPV1, TYR, XDH 11.5431
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 11.5431
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 11.5339
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.272
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, POLB, PPARA, PRKCD, PTGES, RORC, SMAD3, SRC, TEK, TRPV1, TYR 10.8363
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.6432
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3708
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GLO1, HSPA1A, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 9.60386
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, POLB, PPARA, PRKCD, PTGES, RORC, SRC, TEK, TRPV1, TYR 9.54466
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 9.44175
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, TBXAS1 9.44175
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, SMAD3, SRC, TEK, XDH 9.44175
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, TBXAS1 9.12928
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PRKCD, PTGES, SRC 9.09731
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PRKCD, PTPN1, SRC, TEK, XDH 9.06292
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, POLB, PPARA, PRKCD, PTGES, RORC, SMAD3, SRC, TEK, TRPV1, TYR 9.05221
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, F10, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, TRPV1 9.01569
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 8.9885
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, ERBB2, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MIF, PTPN1, SRC, TEK, XDH 8.95248
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CHRM1, CYP19A1, CYP1B1, DRD3, EGFR, ERBB2, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, SMAD3, SRC, TEK 8.89197
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 8.8237
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 8.81891
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 8.62503
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, FABP3, FLT3, IGF1R, INSR, KIT, MMP2, PPARA, PRKCD, SMAD3, SRC, TEK, TRPV1 8.07745
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, SMAD3, SRC, TEK 8.0323
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 7.89907
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, SMAD3, SRC, TEK 7.85232
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 7.83827
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ERBB2, FLT3, KIT, MET, MIF, PIM1, POLA1, PRKCD, SRC, TEK, TYR 7.81774
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR 7.81774
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PIM1, POLB, PPARA, PRKCD, RORC, SMAD3, SRC, TEK, TOP2A, TYR 7.79031
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 7.69211
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.62156
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK 7.61338
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CACNA1C, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, F10, F3, FABP4, HSD17B2, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, RORC, SMAD3, SRC, TEK, TRPV1, TYR 7.60843
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, TBXAS1 7.59253
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, SMAD3, SRC, TEK 7.55651
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.54475
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ERBB2, FABP3, FABP4, FUT7, KIT, MET, MIF, PPARA, PTGES, TBXAS1 7.54183
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, PRKCD, PTPN1, SMAD3, SRC, TEK 7.54006
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, EGFR, ERBB2, F10, F3, INSR, KIT, MET, SRC, TEK, XDH 7.41059
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, F10, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 7.3863
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 7.34301
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PRKCD, PTPN1, RORC, SMAD3, SRC, TOP2A, TRPV1 7.24719
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, FLT3, PTGES, RORC, SRC, TEK, TRPV1, TYR 7.2069
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 7.2069
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.07495
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, KIT, PPARA, PRKCD, SRC, TEK, TRPV1 7.01826
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PRKCD, RORC, SMAD3, SRC, TRPV1 7.01826
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, CHRM5, DRD3, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 6.98532
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, CHRM5, DRD3, DUSP3, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 6.91676
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA, PTGES, TBXAS1 6.91676
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 6.87863
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, POLB, PPARA, SMAD3, SRC, TEK, TYR 6.75224
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2 6.73999
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CSNK2A1, DRD3, EGFR, ERBB2, F3, FLT3, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, TEK 6.67939
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, PRKCD, RORC, SMAD3, SRC, TRPV1 6.55927
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F10, F3, INSR, KIT, MET, SRC, TEK 6.55733
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, DRD3, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC, TRPV1 6.37738
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.37738
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, TRPV1 6.15411
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PRKCD, PTPN1, SMAD3, SRC, TEK 6.14154
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.92931
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, KIT, PPARA, PRKCD, RORC, SRC, TEK 5.92931
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCD, PTPN1, SRC, TEK, XDH 5.90458
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP3, FLT3, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 5.88423
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FABP3, FLT3, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 5.88423
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 5.88423
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, MAOA, TBXAS1, TYR, XDH 5.84945
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TRPV1, TYR, XDH 5.84945
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD3, EGFR, HSPA1A, KIT, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 5.83329
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CHRM1, CYP19A1, DRD3, EGFR, ERBB2, GPR35, HCAR2, HSPA1A, INSR, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, SMAD3, SRC, TRPV1 5.78029
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MIF, PRKCD, PTPN1, SRC, TEK, XDH 5.7246
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 5.7246
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ERBB2, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, MMP9, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK, TYR 5.7
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.6425
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.6425
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TRPV1, TYR, XDH 5.6306
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 5.60052
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 5.60033
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCD, PTPN1, SRC, TEK, XDH 5.55328
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PPARA, PTGES, TBXAS1 5.52048
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, HSPA1A, KIT, MIF, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PRKCD, PTGES, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 5.51276
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK 5.4307
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD3, EGFR, ERBB2, HCAR2, INSR, MIF, MMP12, PRKCD, SMAD3, SRC, TRPV1 5.42608
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 5.41537
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC 5.37143
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, KIT, PRKCD, SRC, TEK 5.34698
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.34337
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TEK 5.33927
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, AXL, BCL2, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CYP1B1, DRD3, EGFR, ERBB2, F3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PRKCD, SMAD3, SRC, TEK, TRPV1, XDH 5.31786
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, PRKCD, SRC, TEK 5.30284
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, ERBB2, FLT3, INSR, KDR, KIT, MIF, PTPN1, SRC, TEK, XDH 5.22471
[BP] GO:0044057 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, DRD3, EGFR, GPR35, HCAR2, KIT, SMAD3, TRPV1 5.15114
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 5.10613
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 5.00589
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, PTGES, RORC, SRC, TYR 4.99037
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.93122
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, ERBB2, PPARA, SMAD3 4.90998
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, TRPV1 4.9085
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AXL, BCL2, CA2, CHRM3, CYP1B1, DRD3, EGFR, F3, HCAR2, HSPA1A, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TRPV1 4.90283
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SRC, TEK, XDH 4.86125
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KIT, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 4.76541
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, DRD3, EGFR, HCAR2, KDR, MIF, SRC, TRPV1 4.75318
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGES 4.73776
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, SRC, TEK, TRPV1, TYR 4.70214
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD3, KDR, POLB, PRKCD, SRC 4.66107
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 4.64554
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA1, CA2, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD3, EGFR, ERBB2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 4.62893
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KIT, MIF, MMP9, NUAK1, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 4.62386
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, F10, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK, TOP2A 4.62174
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.62125
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SRC, TEK, XDH 4.61335
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ERBB2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.5799
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.50917
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 4.46601
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TRPV1, TYR, XDH 4.46466
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MIF, MMP9, PPARA, PRKCD, PTPN1, SRC, TEK, XDH 4.46466
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SRC, TEK, XDH 4.45053
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, DRD3, KDR, SRC, TRPV1 4.43169
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, ERBB2, KDR, MIF, PTPN1, SRC, TEK 4.42865
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, PRKCD, SRC, TEK, TRPV1 4.41012
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.38983
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, CHRM1, DRD3, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, PTPN1, SMAD3, SRC 4.38061
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 4.36647
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.32739
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, SRC, TEK, TRPV1, TYR 4.32712
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD3, EGFR, KIT, PPARA, RORC, SRC, TOP2A 4.30919
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 4.27867
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.25877
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 4.2305
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, KDR, POLB, PRKCD, SRC, TRPV1 4.20201
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, INSR, MIF, SRC 4.17794
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.16115
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK 4.15372
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.13618
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, MIF, PRKCD, PTPN1, SRC 4.10253
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PRKCD, SMAD3, TRPV1, XDH 4.10228
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 4.10103
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, F3, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 4.09655
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, TRPV1 4.09381
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 4.04405
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, F3, FLT3, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 3.99544
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CYP19A1, DRD3, DUSP3, EGFR, ERBB2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 3.99321
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3 3.98378
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.96763
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCD, PTPN1, SRC, TEK, XDH 3.95239
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PRKCD, SRC, TEK 3.95239
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, EGFR, ERBB2, FLT3, IGF1R, INSR, KIT, MMP2, PRKCD, SMAD3, SRC, TRPV1 3.88083
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC 3.87087
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, ERBB2, FABP4, FLT3, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK 3.86495
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD11B1, HSD17B1, HSD17B2 3.84462
[BP] GO:0035556 intracellular signal transduction ADRB1, AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD3, EGFR, ERBB2, IGF1R, INSR, KDR, KIT, MET, MIF, NUAK1, POLB, PRKCD, PTPN1, SRC, TEK 3.82913
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, F3, FLT3, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 3.81303
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, ERBB2, FLT3, IGF1R, INSR, KIT, MIF, PRKCD, PTPN1, SRC 3.77926
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD3, MAOA, TYR 3.77866
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD3, DUSP3, EGFR, ERBB2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SMAD3, SRC, XDH 3.75202
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.73759
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD3, DUSP3, EGFR, ERBB2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SMAD3, SRC, XDH 3.73759
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD11B1, HSD17B1, HSD17B2 3.73759
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, F3, FLT3, HSPA1A, INSR, KIT, MIF, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 3.72254
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD3, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCD, PTPN1, SRC 3.71944
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DRD3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, SMAD3, SRC, TEK 3.69518
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, CHRM1, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, SMAD3, SRC 3.69468
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, INSR, KIT, MIF, PTPN1, SRC 3.69468
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, DUSP3, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, PTPN1, SRC, XDH 3.68062
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, CHRM1, DRD3, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, PTPN1, SMAD3, SRC 3.67817
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, PRKCD, SMAD3, SRC 3.67257
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD3, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3, TRPV1 3.63646
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 3.61481
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, SMAD3, TRPV1, XDH 3.614
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD3, EGFR, HSPA1A, MAOA 3.59819
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, FLT3, RORC, SRC, TRPV1 3.59308
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.58925
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.58925
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 3.565
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, PRKCD, RORC, SMAD3, SRC, TRPV1 3.56415
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR 3.55974
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, F3, FLT3, HSPA1A, INSR, KIT, MET, MIF, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 3.54489
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, INSR, KDR, KIT, MIF, MMP9, PRKCD, PTPN1, SRC, TEK, XDH 3.54037
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 3.53897
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.5268
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 3.50161
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, PRKCD, SRC, TRPV1 3.49906
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, PRKCD, RORC, SRC, TRPV1 3.46099
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK 3.46099
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, PPARA, SMAD3, SRC, TEK 3.39728
[BP] GO:0003018 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, SRC, TEK 3.37388
[BP] GO:0007188 None ADORA1, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3 3.35724
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.33336
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.32433
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, POLA1, POLB, PRKCD, PTPN1, SRC, TOP2A, TRPV1 3.31905
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD3, EGFR, HCAR2, MIF, MMP12, SRC, TRPV1 3.31231
[BP] GO:0051223 None ACHE, APP, CACNA1C, CHRM1, DRD3, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, PTPN1, SMAD3, SRC 3.29305
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, EGFR, ERBB2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.29117
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD3, EGFR, F3, FABP4, KDR, MET, MIF, MMP12, PPARA, PRKCD, SMAD3, TEK 3.29024
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9, TRPV1 3.25641
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.25641
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.25641
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, CHRM1, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, SMAD3, SRC 3.24836
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.2408
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.2408
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CACNA1C, CHRM1, CSNK2A1, DRD3, EGFR, ERBB2, HCAR2, MIF, MMP12, PRKCD, PTPN1, SMAD3, SRC 3.23844
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, ERBB2, FLT3, INSR, KIT, MIF, PRKCD, PTPN1, SRC, TEK 3.23844
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.22593
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, PRKCD, SRC, TRPV1 3.21229
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TEK, TYR 3.19888
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.18185
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TOP2A 3.18092
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD3, HSPA1A, KIT, MIF, MMP9, PRKCD, TRPV1, XDH 3.17527
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.17426
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, KIT 3.1498
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, PRKCD, SMAD3, TEK 3.14465
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.14159
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, RORC 3.11192
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, PRKCD, SMAD3, TEK 3.09173
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC, TRPV1 3.08338
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CHRM1, DRD3, GPR35, MIF, MMP9, PRKCD 3.06526
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ERBB2, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 3.03913
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.03445
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.02346
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, INSR, KIT, MIF, PRKCD, PTPN1, SRC 3.02346
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.02346
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD 3.00296
[BP] GO:0007187 None ADORA1, ADRB1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3 2.9763
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, EGFR, INSR, MAOA, SMAD3, TRPV1 2.97604
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, INSR, MMP2, PRKCD, SRC, TRPV1 2.95083
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.94339
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.93175
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.91132
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.91132
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.88021
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.87225
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.86393
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGES 2.86385
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 2.85431
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, INSR, KIT, MIF, PTPN1, SRC 2.8489
[BP] GO:0042060 None ALOX15, EGFR, ERBB2, PPARA, SMAD3 2.84167
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, ERBB2, HCAR2, HSPA1A, KIT, MIF, MMP12, MMP2, PRKCD, PTPN1, SMAD3, SRC 2.83578
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.82404
[BP] GO:0018958 None AKR1B1, BCL2, DRD3, MAOA, TYR 2.82144
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, MIF, SRC, TEK 2.80602
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, MIF, PTGES 2.77635
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PRKCD, SRC, TEK, TRPV1 2.7457
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD3, MIF, PPARA, PRKCD, SMAD3, TEK 2.73871
[BP] GO:0070848 response to growth factor APP, EGFR, ERBB2, INSR, KDR, SMAD3, SRC, TRPV1 2.73871
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF, PRKCD 2.72832
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD3, EGFR, FABP3, GPR35, SMAD3, TRPV1 2.72071
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, ERBB2, KDR, NUAK1, PPARA, PRKCD, SMAD3, SRC, TEK 2.72071
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.71607
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.71607
[BP] GO:0003013 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR, SRC, TEK 2.71295
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 2.70692
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 2.70692
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK 2.69898
[BP] GO:1903522 None ADORA1, ADORA3, ADRB1, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR 2.68905
[BP] GO:0045776 None ADORA1, ADRB1, DRD3, PPARA 2.68336
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AXL, BCL2, CDC25B, CYP1A1, EGFR, ERBB2, FABP4, FLT3, FUT7, GLO1, KDR, KIT, MET, MIF, MMP2, MMP9, PRKCD, RORC, SMAD3, SRC, TEK, TOP2A 2.68324
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, PRKCD, SRC 2.68324
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PRKCD, PTPN1, SMAD3 2.66113
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, POLB, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 2.65229
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.65022
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD3, DUSP3, EGFR, ERBB2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTPN1, SMAD3, SRC, XDH 2.59497
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.57534
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 2.5742
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.56426
[BP] GO:0048731 system development ACHE, ADORA1, ALPL, CACNA1C, CHRM1, CHRM2, CHRM3, ERBB2, MMP9, SMAD3, SRC, TEK 2.54041
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD3, EGFR, KIT 2.54041
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD3, EGFR, KIT 2.54041
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.5013
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, F10, F3, MET, PRKCD, XDH 2.46664
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.46664
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46664
[BP] GO:0002520 None CACNA1C, SMAD3 2.46664
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK 2.46444
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD3, EGFR, HSPA1A, INSR, MIF 2.45906
[BP] GO:0090257 None ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, KIT, SMAD3 2.45804
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, HCAR2, MMP9, PRKCD, SMAD3, SRC, TOP2A, TRPV1, XDH 2.45699
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, KIT, MET 2.44328
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, PRKCD, RORC, SMAD3, TRPV1 2.44019
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CHRM1, CHRM3, CSNK2A1, DUSP3, EGFR, ERBB2, F10, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 2.43715
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.43078
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.43078
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MIF, POLB, PRKCD 2.43078
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, HCAR2, MMP9, PRKCD, SMAD3, SRC, TOP2A, TRPV1, XDH 2.42722
[BP] GO:0042752 None ADORA1, DRD3, PPARA, RORC, TOP2A 2.41191
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.39206
[BP] GO:0006937 None ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, KIT 2.39138
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, KIT, PRKCD, RORC, SMAD3 2.38083
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.3771
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CHRM2, CYP1A1, DRD3, EGFR, HSPA1A, INSR, KDR, MET, MMP1, MMP12, POLA1, PRKCD, SMAD3, SRC 2.36976
[BP] GO:0003008 None ADORA1, ADRB1, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, DRD3, EGFR, INSR, KIT, SRC, TEK, TRPV1, TYR 2.3673
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC 2.3673
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.3673
[BP] GO:0050994 None ADORA1, HCAR2, PPARA, PRKCD 2.3673
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.3673
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.36593
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.36593
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.36593
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.36593
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, CYP2D6, DRD3, DUSP3, EGFR, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH 2.35928
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, DRD3, EGFR, F10, FABP3, HSPA1A, KIT, MIF, MMP12, MMP9, PPARA, PRKCD, SRC, TRPV1, XDH 2.34965
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.34901
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.33
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.32955
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, DRD3, EGFR, KIT, MMP12, PRKCD, PTGES, SMAD3, SRC, TRPV1, TYR 2.32955
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.32437
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.31868
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.31868
[BP] GO:0050678 None EGFR, ERBB2, F3, KDR, MMP12, SMAD3, TEK, XDH 2.31318
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD3, EGFR, GPR35, SMAD3, TRPV1 2.27995
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.26164
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9 2.26101
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, KIT, MIF, PTPN1, SRC 2.25002
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, PTPN1, XDH 2.24281
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, KIT, MIF, POLB, PTGES, TRPV1 2.24233
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.23636
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.23636
[BP] GO:0050679 None EGFR, ERBB2, F3, KDR, MMP12, TEK 2.2292
[BP] GO:0040008 regulation of growth ADRB1, APP, BCL2, CSNK2A1, DRD3, EGFR, ERBB2, HSPA1A, INSR, PIM1, SMAD3 2.2273
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2273
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DRD3, EGFR, ERBB2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 2.22069
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.22069
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MET, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK 2.2161
[BP] GO:0002793 None ACHE, ADORA1, EGFR, HCAR2, MIF, MMP12, SRC 2.21242
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM1, CHRM3, CHRM5, DRD3, F10, FABP3, HSPA1A, KIT, MIF, MMP12, MMP9, PPARA, PRKCD, SRC, TRPV1, XDH 2.2021
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRB1, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.19809
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM5, DRD3, FABP3, PPARA, TRPV1 2.19173
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.19173
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, HCAR2, MMP9, PRKCD, SMAD3, SRC, TOP2A, TRPV1, XDH 2.19124
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1699
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIM1, POLA1, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.16008
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, MAOA 2.15765
[BP] GO:0050920 regulation of chemotaxis CYP19A1, F3, KDR, MET, MIF, SMAD3 2.15515
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD3, MAOA 2.15515
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 2.14245
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, DRD3, EGFR, HCAR2, MIF, MMP12, SRC 2.14245
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, PRKCD, SRC, TEK 2.12952
[BP] GO:0007423 None BCL2, CACNA1C, CYP1A1, EGFR, KIT 2.12942
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, MIF 2.12886
[BP] GO:0051894 None KDR, SMAD3, TEK 2.12886
[BP] GO:0061900 None APP, EGFR, TRPV1 2.12886
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.12886
[BP] GO:0051336 regulation of hydrolase activity ADRB1, APP, CSNK2A1, EGFR, ERBB2, F3, HSPA1A, KIT, MMP9, NUAK1, PRKCD, PTPN1, SMAD3, SRC, XDH 2.11179
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, MET, TRPV1 2.10276
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, SMAD3, SRC, TEK 2.09577
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.09577
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, HSD17B2, INSR, KIT, SRC 2.09113
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.09113
[BP] GO:0050927 None F3, KDR, SMAD3 2.08578
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PRKCD, PTPN1, SMAD3, SRC, TEK, XDH 2.07492
[BP] GO:0050890 None ADORA1, APP, CHRM1, DRD3, EGFR, INSR, KIT 2.07441
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.06269
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.06152
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.06152
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, DRD3, INSR 2.0598
[BP] GO:0046541 None CHRM1, CHRM3 2.05685
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.05685
[BP] GO:0010641 None F3, SRC 2.05685
[BP] GO:0007598 None F10, F3 2.05685
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.05685
[BP] GO:0050926 None F3, KDR, SMAD3 2.04954
[BP] GO:1903393 None KDR, SMAD3, TEK 2.04954
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.0484
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, INSR, KIT, MMP2, MMP9, SRC, TOP2A 2.03671
[BP] GO:0097746 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR 2.03043
[BP] GO:0035296 None ADORA1, ADRB1, CHRM1, CHRM3, EGFR 2.03043
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AURKB, DRD3, EGFR, ERBB2, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCD, RORC, SMAD3, SRC, TOP2A, TRPV1 2.02804
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, BCL2, DRD3 2.02804
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, MIF, SMAD3 2.02804
[BP] GO:0050793 regulation of developmental process ADRB1, APP, AXL, BCL2, CA2, CYP1B1, DRD3, EGFR, ERBB2, F3, INSR, KDR, KIT, MIF, NUAK1, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TRPV1, XDH 2.02599
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, MIF 2.02136
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.02076
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CYP1B1, ERBB2, FABP3, HSPA1A, PTGES, SMAD3, XDH 2.01484
[BP] GO:0032069 None HSPA1A, PRKCD, PTPN1 2.01484
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.00928
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.00899
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD3, EGFR, ERBB2, F10, F3, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PRKCD, PTPN1, SMAD3, SRC, TEK, TRPV1 4.76216
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, EGFR, ERBB2, F10, F3, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP2, PIM1, PRKCD, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR 4.50939
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRB1, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TRPV1 4.41471
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, KIT, MAOA, MET, PTGES, PTPN1, SRC, TBXAS1, TEK, TRPV1, TYR 4.10894
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 4.0771
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, ERBB2, TEK 3.82921
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.41166
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, DUSP3, EGFR, ERBB2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MIF, MMP2, MMP9, PIM1, POLA1, PRKCD, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TOP2A, TRPV1, TYR, XDH 3.22228
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ERBB2, INSR, MET, SRC, TEK, TRPV1 2.91132
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, ERBB2, HSPA1A, PRKCD, PTGES, SRC, TYR 2.84609
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRB1, APP, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.77635
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, F10, FLT3, HSD11B1, HSD17B2, PTGES, PTPN1, TBXAS1 2.70445
[CC] GO:0031233 None CA4, F10, F3 2.32758
[CC] GO:0045202 None ACHE, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR 2.16761
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, HSD11B1, HSD17B2, PTGES, TBXAS1 2.12886
[CC] GO:0030054 cell junction ACHE, AKR1B1, APP, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, HCAR2, HSPA1A, KDR, KIT, PRKCD, TEK, TRPV1 2.06037
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, HSPA1A, KDR, PRKCD, PTPN1, XDH 2.0502
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ERBB2, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PRKCD, PTGES, PTPN1, SRC, TBXAS1, TEK, TOP2A, TYR, XDH 16.8962
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.4054
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 14.7304
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP2A, TRPV1, TYR, XDH 13.753
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 11.8002
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3517
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 9.82485
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 9.05221
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD3, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTPN1, RORC, SMAD3, TBXAS1, TOP2A, TRPV1, TYR, XDH 9.04789
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.9885
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD3, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, PRKCD, SRC, TEK, TOP2A, TRPV1 8.9885
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.12088
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, PRKCD, SRC, TEK 8.02738
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTPN1, RORC, SMAD3, TBXAS1, TOP2A, TRPV1, TYR, XDH 7.6356
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, XDH 7.48315
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, INSR, KDR, KIT 7.24719
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, MAOA, TBXAS1, TYR, XDH 7.18421
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR 7.0431
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.83343
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.37738
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ERBB2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK, TRPV1 6.31042
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, TBXAS1 5.99095
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, TBXAS1 5.75498
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 5.74469
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ERBB2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, TEK, TRPV1 5.69671
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ERBB2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, TEK, TRPV1 5.69671
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 5.51437
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ERBB2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK, TRPV1 5.41748
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR 5.39494
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ERBB2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, SMAD3, TEK, TRPV1 5.29168
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, EGFR, ERBB2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK, TRPV1 5.19389
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.19389
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, POLA1, PTGES, SRC, TBXAS1, XDH 4.67883
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 4.54935
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, POLB, PRKCD, SRC, TEK 4.48648
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.36647
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK 4.10718
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.97406
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, INSR, KDR, KIT, SMAD3 3.96958
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR 3.73759
[MF] GO:0019899 enzyme binding ADRB1, APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ERBB2, F3, HSPA1A, KIT, MET, MIF, POLA1, POLB, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 3.54654
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.42514
[MF] GO:0008227 None ADRB1, CHRM1, CHRM2, CHRM3, CHRM5 3.38183
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.24046
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA, PTPN1, SMAD3 3.24046
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.18185
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, PTGES, SRC, TEK, TOP2A, TRPV1, XDH 3.17527
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ERBB2, F10, F3, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCD, PTPN1, SRC, TEK 3.03445
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 3.02346
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PRKCD 3.02346
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 2.89692
[MF] GO:0008389 None CYP2A13, CYP2A6 2.87225
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 2.86393
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, POLA1, PTPN1 2.86135
[MF] GO:0019838 growth factor binding EGFR, ERBB2, IGF1R, INSR, KDR, TEK 2.83588
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.82843
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 2.73871
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.72832
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCD, SRC, TEK, TOP2A, TRPV1, XDH 2.6599
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.54041
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCD, SRC, TEK, TOP2A, TRPV1, XDH 2.46444
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCD, SRC, TEK, TOP2A, TRPV1, XDH 2.46286
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3 2.23131
[MF] GO:0051425 None APP, INSR 2.2273
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, PRKCD, SRC, TEK, TOP2A, TRPV1 2.14192
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, MET, PTPN1 2.10276
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.10232
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP9, SMAD3, TOP2A, TRPV1, TYR, XDH 2.09577
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.09113
[MF] GO:0043559 insulin binding IGF1R, INSR 2.05685
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, ERBB2, KIT, MET 2.0484
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 2.02753
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.01484
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.01484
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.00053


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.5646
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.7943
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, ERBB2, MET, EGFR, IGF1R 8.7943
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.7637
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.2479
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.2276
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2, CACNA1C 5.0885
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, ADORA3, CHRM5, ADORA1, ADRB1, TRPV1, DRD3 5.2813
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, AKR1B1, TYR, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 4.9884
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, KIT, ERBB2, BCL2, MMP9, MET, EGFR, IGF1R 4.9543
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, ERBB2, ADRB1, CACNA1C, EGFR 4.9465
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KIT, KDR, BCL2, TEK, MET, EGFR, IGF1R 4.7889
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, ADRB1, MET, EGFR, IGF1R, HSPA1A 4.8219
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 4.6792
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.5805
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PRKCD, BCL2, PIM1, F3 4.4637
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.8303
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, PRKCD, MMP9, EGFR, HSPA1A 4.4908
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, ERBB2, BCL2, TEK, EGFR, IGF1R 4.4364
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, CYP2D6, ALOX5, ALOX15, CACNA1C 4.247
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, ADRB1, CACNA1C, PPARA 3.862
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 3.8386
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, ERBB2, MET, EGFR 4.1878
MicroRNAs in cancer_Homo sapiens_hsa05206 ERBB2, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.6851
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.5819
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD, CACNA1C, EGFR 3.628
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, EGFR 2.8735
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, ADRB1 3.3081
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRB1, CACNA1C 2.519
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR, IGF1R 2.6123
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGES 3.1495
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2 2.997
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.8259
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PRKCD, PPARA 2.3175
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.997
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.0345
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 1.9539
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, CACNA1C, EGFR, CDC25B, HSPA1A 1.8564
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.7948
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.1365
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0345
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6934
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, ERBB2, EGFR 2.0161
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.9539
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.0345
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.7411
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR, PRKCD, CACNA1C 2.3303
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9889
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCD, TRPV1 1.6459
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.0252
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, EGFR 1.7357
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.4492
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4366
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C, DRD3 1.3669
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, KIT, EGFR 1.2616
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.2435
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.2951
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.195
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.9897
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, MIF, TYR 2.6988
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.269
Alcoholism_Homo sapiens_hsa05034 MAOA 0.2759
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.806
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2799
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 0.8136
Taste transduction_Homo sapiens_hsa04742 CHRM3, CACNA1C 1.0142
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.817
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3181
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.803
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9469
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.7615
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7706
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD, CACNA1C 0.8136
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.9897
Insulin secretion_Homo sapiens_hsa04911 CHRM3, CACNA1C 1.0011
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.803
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7498
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3435
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7113
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.7469
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.9363
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9897
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.355
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7469
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.6912
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6633
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6394
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9694
Salivary secretion_Homo sapiens_hsa04970 CHRM3, ADRB1 0.988
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.4693
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.0876
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.5667
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 0.988
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0518
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6354
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.988
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6637
Axon guidance_Homo sapiens_hsa04360 MET 0.3699
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC, PRKCD 0.6071
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9727
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3778
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9578
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.3889
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4073
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0474
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3978
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.421
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2065
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4284
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4284
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1793
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4206
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.1608
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4284
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCD 0.4432
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4414
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4414
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4479
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.1995
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.257
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.2977
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4679
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.453
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4624
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1793
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4693
Peroxisome_Homo sapiens_hsa04146 XDH 0.4693
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2272
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4947
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4796
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4693
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.4966
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4814
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5007
Bile secretion_Homo sapiens_hsa04976 CA2 0.4987
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4928
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5196
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5196
Shigellosis_Homo sapiens_hsa05131 SRC 0.5196
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5459
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3848
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5725
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5984
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6028
Malaria_Homo sapiens_hsa05144 MET 0.6071
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.6071
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6649
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6914
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9543
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7044
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.697
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6637
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6459
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5675
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6637
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.6336
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7706
DNA replication_Homo sapiens_hsa03030 POLA1 0.6912
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7383
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8608
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7734
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7469
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.0351
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7706
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8019
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9727


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)