TCM-ID Component

Description of the Component

Component ID	TCMH1453
Latin Name	Ilex pubescens
English Name	Pubescent holly
Chinese Pinyin Name	Mao Dong Qing
中文名	æ¯›å†¬é’
TCM Properties
TCM Meridians
Therapeutic Class English	Blood activation and stasis removal
Therapeutic Class Chinese	æ´»è¡€åŒ–æ·¤
Functions	promote blood circulation remove stasis, dredge the channels and collaterals, clear heat and toxic materials, eliminate phlegm, and relieve cough and asthma
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID	ITSAN840-14
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx3828	Bo Gu Decoction	é©³éª¨æ°´
TCMFx4786	Hu Xin Capsules	æŠ¤å¿ƒèƒ¶å›Š
TCMFx4403	Jian Xin Tablets	å¥å¿ƒç‰‡
TCMFx4063	Kang Feng Shi Oral Liquid	æŠ—é£Žæ¹¿æ¶²
TCMFx4295	Mao Dong Qing Capsules	æ¯›å†¬é’èƒ¶å›Š
TCMFx4303	Mao Dong Qing Zhu She Oral Liquid	æ¯›å†¬é’æ³¨å°„æ¶²
TCMFx4503	Pen Yan Qing Shuan	ç›†ç‚Žæ¸…æ “
TCMF6376	Xiao Yan Ling Tablets	æ¶ˆç‚Žçµç‰‡
TCMF6822	Xin Mai Tong Tablets	å¿ƒè„‰é€šç‰‡
TCMFx384	Xin Shu Ning Tablet	å¿ƒèˆ’å®ç‰‡
TCMFx5997	Xin Shu Ning Tablets	å¿ƒèˆ’å®ç‰‡
TCMFx6561	Xue Shuan Xin Mai Ning Capsules	è¡€æ “å¿ƒè„‰å®èƒ¶å›Š
TCMFx142	Xue Shuan Xin Mo Ning Tablets	è¡€æ “å¿ƒè„‰å®ç‰‡
TCMF6575	Xue Ya Ping Tablets	è¡€åŽ‹å¹³ç‰‡
TCMFx458	XueÂ Shuan XinÂ MaiÂ Ning Capsule	è¡€æ “å¿ƒè„‰å®èƒ¶å›Š
TCMFx6659	Yan Jian Ning Tablets	ç‚Žè§å®ç‰‡
TCMFx7131	Zhi Shang Ruan Ointment	æ²»ä¼¤è½¯è†
TCMFx6309	Zhong Gan Ling Tablets	é‡æ„Ÿçµç‰‡

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT101	PTPN1	Protein-tyrosine phosphatase 1B	Hydrolase	P18031
TCMT103	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	Hydrolase	P10586
TCMT171	PTPN6	Protein-tyrosine phosphatase 1C	Hydrolase	P29350
TCMT174	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	Oxidoreductase	P28845
TCMT30	PTGS2	Cyclooxygenase-2	Oxidoreductase	P35354

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1107	Protease
TCMT1218	Staphylococcus aureus
TCMT1229	Enterococcus faecalis
TCMT1255	Human immunodeficiency virus 1
TCMT1257	Colletotrichum lagenarium

Ingredient Structrues

Ingredient ID: TCMC943
Formula: C30H48O4

Common Name	Corosolic Acid
IUPAC Name	(1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
Canonical SMILES	C[C@@H]1CC[C@]2([C@@H]([C@H]1C)C1=CC[C@H]3[C@@]([C@@]1(CC2)C)(C)CC[C@@H]1[C@]3(C)C[C@@H](O)[C@@H](C1(C)C)O)C(=O)O
Standard InCHI	InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
Standard InCHIKey	HFGSQOYIOKBQOW-ZSDYHTTISA-N
External Identifiers	ChEMBL [CHEMBL391533]; PubChem [6918774];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1862	Cornus officinalis	Shan Zhu Yu	å±±èŒ±è¸
TCMH611	Rubus idaeus	Fu Pen Zi	è¦†ç›†å
TCMH1753	Boswellia carterii	Ru Xiang	ä¹³é¦™
TCMH1453	Ilex pubescens	Mao Dong Qing	æ¯›å†¬é’
TCMH1333	Clerodendron cyrtophyllum	Lu Bian Qing	è·¯è¾¹é’
TCMH25	Styrax benzoin	An Xi Xiang	å®‰æ¯é¦™
TCMH719	Dryopteris crassirhizoma	Guan Zhong	è´¯ä¼—
TCMH108	Perilla frutescens	Bai Su Zi	ç™½è‹å
TCMH1432	Vitex trifolia	Man Jing Zi	è”“è†å
TCMH95	Aquilaria sinensis	Bai Mu Xiang	ç™½æœ¨é¦™
TCMH388	Ziziphus jujuba	Da Zao	å¤§æž£
TCMH1615	Eriobotrya japonica	Pi Ba Ren	æž‡æ·ä»
TCMH1033	Centella asiatica	Ji Xue Cao	ç§¯é›ªè‰
TCMH970	Vitex negundo	Huang Jing Zi	é»„è†å
TCMH1660	Senecio scandens	Qian Li Guang	åƒé‡Œå…‰
TCMH1135	Rosa laevigata	Jin Ying Zi Ti Qu Ye	é‡‘æ¨±åæå–æ¶²
TCMH906	Viscum coloratum	Hu Ji Sheng	æ§²å¯„ç”Ÿ
TCMH1175	Cornus officinalis	Jiu Yu Rou	é…’è¸è‚‰
TCMH1431	Vitex trifolia	Man Jing Ye	è”“è†å¶
TCMH1133	Rosa laevigata	Jin Ying Zi	é‡‘æ¨±å
TCMH1134	Rosa laevigata	Jin Ying Zi Rou	é‡‘æ¨±åè‚‰
TCMH2729	Campsis grandiflora	Zi Wei Gen Pi	ç´«è‘³æ ¹çš®
TCMH2134	Smilax glabra	Tu Fu Ling	åœŸèŒ¯è‹“
TCMH2286	Berberis julianae	Xiao Bo Gen	å°æª—æ ¹
TCMH2261	Fritillaria thunbergii	Xiang Bei	è±¡è´
TCMH2206	Schisandra chinensis	Wu Wei Zi Liu Jin Gao	äº”å‘³åæµæµ¸è†
TCMH2213	Ipomoea cairica	Wu Zhao Long	äº”çˆªé¾™
TCMH2202	Schisandra chinensis	Wu Wei Zi	äº”å‘³å
TCMH2203	Schisandra chinensis	Wu Wei Zi Chun Jin Gao	äº”å‘³åé†‡æµ¸è†
TCMH2204	Schisandra chinensis	Wu Wei Zi Jin Chu Wu	äº”å‘³åæµ¸å‡ºç‰©
TCMH2205	Schisandra chinensis	Wu Wei Zi Jin Gao	äº”å‘³åæµ¸è†

Ingredient ID: TCMC618
Formula: C32H50O4

Common Name	Acetyl Oleanolic Acid
IUPAC Name	(4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-acetyloxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Canonical SMILES	CC(=O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C
Standard InCHI	InChI=1S/C32H50O4/c1-20(33)36-25-12-13-29(6)23(28(25,4)5)11-14-31(8)24(29)10-9-21-22-19-27(2,3)15-17-32(22,26(34)35)18-16-30(21,31)7/h9,22-25H,10-19H2,1-8H3,(H,34,35)/t22-,23-,24+,25-,29-,30+,31+,32-/m0/s1
Standard InCHIKey	RIXNFYQZWDGQAE-DFHVBEEKSA-N
External Identifiers	ChEMBL [CHEMBL486822]; PubChem [151202];
Reference of Component-Ingredient Pair	16076639

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1453	Ilex pubescens	Mao Dong Qing	æ¯›å†¬é’
TCMH213	Boschniakia rossica	Cao Cong Rong	è‰è‹è“‰
TCMH1597	Ligustrum lucidum	Nv Zhen Zi	å¥³è´žå
TCMH1272	Forsythia suspensa	Lian Qiao	è¿žç¿˜
TCMH2218	Rubia cordifolia	Qian Cao Teng	èŒœè‰è—¤

Ingredient ID: TCMC1711
Formula: C42H30O9

Common Name	n.a.
IUPAC Name	n.a.
Canonical SMILES	Oc1cc2c3c(c1)O[C@H]([C@@H]3c1cc(O)cc3c1[C@@H](c1c4[C@H]2[C@H](Oc4cc(c1)O)c1ccc(cc1)O)[C@@H](O3)c1ccc(cc1)O)c1ccc(cc1)O
Standard InCHI	InChI=1S/C42H30O9/c43-22-7-1-19(2-8-22)40-37-28-13-25(46)17-32-35(28)39(42(50-32)21-5-11-24(45)12-6-21)30-15-27(48)18-33-36(30)38(29-14-26(47)16-31(49-40)34(29)37)41(51-33)20-3-9-23(44)10-4-20/h1-18,37-48H/t37-,38-,39+,40+,41+,42-/m1/s1
Standard InCHIKey	KUTVNHOAKHJJFL-ZSIJVUTGSA-N
External Identifiers	ChEMBL [CHEMBL443463]; PubChem [196402];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH1453	Ilex pubescens	Mao Dong Qing	æ¯›å†¬é’
TCMH1446	Vaccinium oxycoccos	Man Yue Mei	è”“è¶ŠèŽ“
TCMH1518	Chaenomeles sinensis	Mu Gua	æœ¨ç“œ
TCMH2232	Scutellaria amoena	Xi Nan Huang Qin	è¥¿å—é»„èŠ©

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC618	C32H50O4	Acetyl Oleanolic Acid	498.37	2.5089	4.54	9.792	4	1	63.6	12	5	36	1
TCMC943	C30H48O4	Corosolic Acid	472.36	1.2611	4.32	8.142	4	3	77.76	11	5	34	1
TCMC1711	C42H30O9		678.19	-3.768	5.09	5.784	0	6	149.07	9	10	51	2

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Data Section	Select to Download
1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Ilex pubescens æ¯›å†¬é’

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC943

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC618

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC1711

Occurrence of the ingredient across TCM components

Properties

Download Data

Component: Ilex pubescens æ¯›å†¬é’