TCM Prescription: Xiao Yan Ling Tablets



Prescription Description
Prescription IDTCMF6376
Pinyin NameXiao Yan Ling Pian
Chinese Name消炎灵片
English NameXiao Yan Ling Tablets
Function Description喉痹, 痢疾
IndicationsDysentery disorder, Pharyngitis, Dysentery
Disease ICD-11 Category SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1220 Picria felterrae 苦玄参 TCMH1220
TCMH2649 NA 肿芎风 TCMH2649
TCMH1660 Senecio scandens 千里光 TCMH1660 ITSAJ4346-14
TCMH1453 Ilex pubescens 毛冬青 TCMH1453 ITSAN840-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.63103
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.38242
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.12374
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 6.47714
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, HSD17B2, RORC, TYR 6.04519
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA 6.02865
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.92554
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, MMP2, MMP9, PPARA, RORC, TYR 5.8086
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, MCL1, MMP2, PPARA, RORC, TYR 5.51791
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.35485
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, RORC, TYR 5.35485
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.35485
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.86492
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, FLT3, HSD11B2, HSD17B2, MCL1, MMP2, MMP9, PPARA, RORC, TYR 4.85274
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, PPARA, TYR 4.70723
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.50955
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, BCL2, CA2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, MCL1, MMP2, MMP9, PPARA, RORC, TNKS2, TYR 4.40973
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.40973
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, MCL1, MMP9, PPARA, RORC, TYR 4.38548
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FUT7, GBA2, PPARA, TYR, XDH 4.27811
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MCL1, PPARA, TNKS, TNKS2, XDH 4.0784
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, MCL1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TNKS2, XDH 4.05731
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.02693
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, PPARA 3.98086
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.89344
[BP] GO:0010647 positive regulation of cell communication AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, MCL1, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 3.80592
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 3.80592
[BP] GO:0023056 positive regulation of signaling AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, MCL1, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 3.80592
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, MMP1, MMP2, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 3.80592
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.7551
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.68557
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, MCL1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TNKS2, XDH 3.51312
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 3.38441
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALPL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, MCL1, MMP1, MMP12, MMP2, MMP9, PPARA, RORC, TNKS2, TYR 3.30097
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29078
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, XDH 3.29078
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HSD11B2, MMP2, PPARA 3.28608
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.22877
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.12789
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 3.0312
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.98302
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, MMP12, MMP2, MMP9 2.95324
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.94918
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.9328
[BP] GO:0009115 None AOX1, XDH 2.82616
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.7111
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9 2.61924
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.60473
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FLT3, MMP12, MMP2, MMP9, XDH 2.57779
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, MCL1, MMP12, MMP2, MMP9, PTPN1, TNKS, TNKS2, XDH 2.47673
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.41972
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.41972
[BP] GO:0046110 None AOX1, XDH 2.40472
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.40472
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, MMP2, MMP9, RORC 2.35219
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.31967
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, BCL2, CSNK2A1, CYP1B1, F3, FLT3, MCL1, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 2.27291
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.27235
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.25486
[BP] GO:0070213 None TNKS, TNKS2 2.15317
[BP] GO:0006145 None AOX1, XDH 2.15317
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.15317
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.14749
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP4, GBA2 2.14062
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.13663
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.11816
[BP] GO:0022414 reproductive process AKR1B1, ALPL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9 2.10182
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, PPARA 2.05389
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.0383
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.03739
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FLT3, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 2.00058
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 1.69241
[CC] GO:0043227 membrane-bounded organelle ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, FUT7, GBA2, MCL1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 1.66422
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2 1.53324
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MCL1, MMP2, MMP9, PTPN1, TNKS, TNKS2, TYR, XDH 1.51538
[CC] GO:0005578 proteinaceous extracellular matrix ALPL, MMP1, MMP12, MMP2, MMP9 1.27693
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TYR, XDH 14.1344
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.45545
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 8.3521
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, PTPN1, TNKS, TNKS2, TYR, XDH 7.01613
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.92554
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSD17B1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 5.92554
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.85064
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.78749
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.78749
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.51791
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 5.51791
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.37845
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.35485
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 5.07029
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.86492
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.96117
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.83693
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.80592
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.7551
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.64251
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.22877
[MF] GO:0008289 lipid binding ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 3.10331
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.07162
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.99485
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.96851
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.94478
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.85582
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82616
[MF] GO:0003845 None HSD11B1, HSD11B2 2.82616
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, XDH 2.49575
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.19614
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.15317
[MF] GO:0017171 serine hydrolase activity ACHE, F3, MMP1, MMP12, MMP2, MMP9 2.04856


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 10.3117
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 10.3117
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.5685
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.2434
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.4498
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.476
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, MMP9, CDC25B, MCL1 3.2769
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, ESR1, ESR2 3.177
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.3432
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9 2.7331
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 3.0375
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.5136
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, F3 2.0461
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1, PPARA 2.4694
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2, MMP9 1.71
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1, MCL1 1.6345
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9, ESR1 1.389
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4839
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.3706
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.845
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.389
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9296
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.3642
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.1061
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.2712
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8431
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.107
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1065
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.2217
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8989
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2, MCL1 0.9965
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.9965
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0703
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.9965
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.0562
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9 0.8474
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.8052
Glioma_Homo sapiens_hsa05214 CDK6 0.6472
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.6048
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.5931
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.6472
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.6048
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.6714
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3 0.6472
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.6714
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.6438
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5704
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5924
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6048
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6472
Melanoma_Homo sapiens_hsa05218 CDK6 0.6472
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3 0.3523
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5924
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6048
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3604
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4702
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.5904
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.5196
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.558
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.558
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.5242
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6438
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.5196
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4608
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3 0.6714
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.5064
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6048
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.5091
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.5196
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5196
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5955
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6472
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.4292
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.558
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.4299
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4517
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.4608
cAMP signaling pathway_Homo sapiens_hsa04024 PPARA 0.4306
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.558
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5955
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6472
Peroxisome_Homo sapiens_hsa04146 XDH 0.6108
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.6242
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.6472
Bile secretion_Homo sapiens_hsa04976 CA2 0.6472
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.71
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6931
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7097
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.71
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.71
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7612
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8474
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8386
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8474
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.852
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2769
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8428
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8474
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9965
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0562
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3246


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)