NPASS Compound

Natural Product: NPC487961

Natural Product ID	NPC487961
Common Name ? The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.	JFPVXVDWJQMJEE-IZRZKJBUSA-N
IUPAC Name	n.a.
Synonyms
Synthetic Gene Cluster	n.a.
ChEMBL Identifier	n.a.
PubChem CID	5479529
Chemical Classification	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000002] Organoheterocyclic compounds [CHEMONTID:0000160] Lactams [CHEMONTID:0000162] Beta lactams [CHEMONTID:0000168] Cephems [CHEMONTID:0000173] Cephalosporins [CHEMONTID:0004410] Cephalosporin 3'-carbamates

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

Chemical Representations

RDKit 3D 45 47 0 0 0 0 0 0 0 0999 V2000 -3.7465 -3.0288 0.4074 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.1779 -1.8772 1.0502 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.0178 -0.8275 1.2606 N 0 0 0 0 0 0 0 0 0 0 0 0 -3.8317 0.2597 0.6212 C 0 0 0 0 0 0 0 0 0 0 0 0 -4.7167 1.3783 0.8373 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.3771 2.0522 -0.1696 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.1323 3.0627 0.4222 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.8709 2.9287 1.7855 C 0 0 0 0 0 0 0 0 0 0 0 0 -5.0343 1.9242 1.9642 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.7247 0.3462 -0.3162 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.9144 -0.6125 -0.5434 N 0 0 0 0 0 0 0 0 0 0 0 0 -0.8487 -0.4669 -1.4739 C 0 0 2 0 0 0 0 0 0 0 0 0 0.0311 -1.6218 -1.6692 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.1731 -2.7757 -2.1421 O 0 0 0 0 0 0 0 0 0 0 0 0 1.1693 -0.9689 -1.1396 N 0 0 0 0 0 0 0 0 0 0 0 0 2.5621 -0.9741 -0.7460 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9809 -0.3489 0.3048 C 0 0 0 0 0 0 0 0 0 0 0 0 4.3881 -0.3397 0.7249 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9137 0.9955 0.7536 O 0 0 0 0 0 0 0 0 0 0 0 0 6.2430 1.1039 1.1412 C 0 0 0 0 0 0 0 0 0 0 0 0 6.8961 0.1551 1.7106 N 0 0 0 0 0 0 0 0 0 0 0 0 6.9563 2.2947 0.9210 O 0 0 0 0 0 0 0 0 0 0 0 0 2.1323 0.4391 1.2692 C 0 0 0 0 0 0 0 0 0 0 0 0 0.4197 0.6094 0.7775 S 0 0 0 0 0 0 0 0 0 0 0 0 0.3872 0.2392 -0.9783 C 0 0 2 0 0 0 0 0 0 0 0 0 3.4106 -1.7360 -1.6464 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6294 -1.8410 -1.4889 O 0 0 0 0 0 0 0 0 0 0 0 0 2.9096 -2.4187 -2.7734 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.4965 1.5390 -1.0372 O 0 0 0 0 0 0 0 0 0 0 0 0 -4.5401 -2.7209 -0.3143 H 0 0 0 0 0 0 0 0 0 0 0 0 -4.2730 -3.6316 1.1821 H 0 0 0 0 0 0 0 0 0 0 0 0 -3.0067 -3.5998 -0.1541 H 0 0 0 0 0 0 0 0 0 0 0 0 -5.3448 1.8655 -1.2366 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.7590 3.7649 -0.0775 H 0 0 0 0 0 0 0 0 0 0 0 0 -6.3077 3.5696 2.5372 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.1810 0.0031 -2.4346 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0677 -1.0026 0.2369 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4583 -0.6383 1.8308 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5016 -0.7735 1.9344 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9585 2.2943 0.7910 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5936 1.4704 1.2712 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2664 0.0673 2.3027 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6962 1.1188 -1.5623 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4679 -3.1403 -3.1648 H 0 0 0 0 0 0 0 0 0 0 0 0 -1.5646 1.8627 -1.2539 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 2 3 1 0 3 4 2 0 4 5 1 0 5 6 2 0 6 7 1 0 7 8 2 0 8 9 1 0 4 10 1 0 10 11 2 0 11 12 1 0 12 13 1 0 13 14 2 0 13 15 1 0 15 16 1 0 16 17 2 0 17 18 1 0 18 19 1 0 19 20 1 0 20 21 2 3 20 22 1 0 17 23 1 0 23 24 1 0 24 25 1 0 16 26 1 0 26 27 2 0 26 28 1 0 10 29 1 0 9 5 1 0 25 12 1 0 25 15 1 0 1 30 1 0 1 31 1 0 1 32 1 0 6 33 1 0 7 34 1 0 8 35 1 0 12 36 1 6 18 37 1 0 18 38 1 0 21 39 1 0 22 40 1 0 23 41 1 0 23 42 1 0 25 43 1 6 28 44 1 0 29 45 1 0 M END

Standard InCHIKey	JFPVXVDWJQMJEE-IZRZKJBUSA-N
Standard InCHI	InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1
SMILES	CO/N=C(/c1ccco1)C(=N[C@@H]1C(=O)N2C(=C(COC(=N)O)CS[C@H]12)C(=O)O)O

Calculated Properties

Physi-Chem Properties

Molecular Weight:	424.07	Volume:	371.349 ? Van der Waals volume.
Dense:	1.142	LogP:	0.524 ? The logarithm of the n-octanol/water distribution coefficients.
logD7.4:	0.965 ? The logarithm of the n-octanol/water distribution coefficient at pH=7.4.	LogS:	-2.202 ? The logarithm of aqueous solubility value.
Rotatable Bonds:	8.0	Rigid Bonds:	19.0
TPSA:	178.24 ? Topological Polar Surface Area.	H-Bond Acceptor:	12.0
H-Bond Donor:	4.0	Rings:	3.0
Heavy Atoms:	13.0

MedChem Properties

QED Drug-Likeness Score:	0.212	GASA:	1.0 ? GASA represents the probability of being difficult to synthesize, ranging from 0 to 1.
Synthetic Accessibility Score:	4.355	Fsp³:	0.312
MCE-18:	65.714 ? MCE-18 stands for medicinal chemistry evolution.MCE-18≥45 is considered a suitable value.	Lipinski Rule-of-5:	Rejected
Pfizer Rule:	Rejected	GSK Rule:	Accepted
Golden Triangle Rule:	Rejected	BMS Rule:	1
Chelating Alert:	0	PAINS Alert:	0
Colloidal aggregators:	0.413	Fluc inhibitor:	0.014 ? The fluc inhibitor value is the probability of being fLuc inhibitors, within the range of 0 to 1.
Blue fluorescence:	0.097 ? The blue fluorescence value is the probability of being blue fluorescence, within the range of 0 to 1	Green fluorescence:	0.115 ? The green fluorescence value is the probability of being green fluorescence, within the range of 0 to 1
Reactive compounds:	0.056	Promiscuous compounds:	0.234

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

Caco-2 Permeability:	-6.206	MDCK Permeability:	-5.433
Pgp-inhibitor:	0.85	Pgp-substrate:	0.962
PAMPA:	0.843 ? The experimental data for Peff was logarithmically transformed (logPeff). Molecules with log Peff values below 2.0 were classified as low-permeability (Category 0), while those with log Peff values exceeding 2.5 were classified as high-permeability (Category 1).	Human Intestinal Absorption (HIA):	0.953
20% Bioavailability (F20%):	0.997	30% Bioavailability (F30%):	0.998
50% Bioavailability (F50%):	0.996

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.0	MRP1:	0.161
Plasma Protein Binding (PPB):	43.271%	Volume Distribution (VD):	-0.669
Fu:	51.72% ? The fraction unbound in plasms.	OATP1B1 inhibitor:	0.568
OATP1B3 inhibitor:	0.993	BCRP inhibitor:	0.003
BSEP inhibitor:	0.683

ADMET: Metabolism

CYP1A2-inhibitor:	0.0	CYP1A2-substrate:	0.0
CYP2C19-inhibitor:	0.0	CYP2C19-substrate:	0.0
CYP2C9-inhibitor:	0.992	CYP2C9-substrate:	0.0
CYP2D6-inhibitor:	0.006	CYP2D6-substrate:	0.0
CYP3A4-inhibitor:	0.017	CYP3A4-substrate:	0.0
CYP2B6-substrate:	0.0	CYP2C8-inhibitor:	0.011
HLM stability:	0.004 ? Human liver microsomal (HLM) stability. Category 0: stable+ (HLM > 30 min); Category 1: unstable- (HLM ≤ 30 min). The output value is the probability of human liver microsomal instability, where a value closer to 1 indicates a higher likelihood of instability.

ADMET: Excretion

Clearance (CL):

1.203

Half-life (T1/2):

1.604

ADMET: Toxicity

hERG Blockers:	0.013	hERG Blockers (10um):	0.01
Human Hepatotoxicity (H-HT):	0.996	Drug-induced Liver Injury (DILI):	1.0
AMES Toxicity:	0.346	Rat Oral Acute Toxicity:	0.093
Maximum Recommended Daily Dose:	0.001	Skin Sensitization:	1.0
Carcinogencity:	0.606	Eye Corrosion:	0.0
Eye Irritation:	0.363	Respiratory Toxicity:	0.306
Drug-induced Neurotoxicity:	0.0	Ototoxicity:	0.895
Hematotoxicity:	0.616	Drug-induced Nephrotoxicity:	0.998
Genotoxicity:	1.0	RPMI-8226 Immunitoxicity:	0.005
A549 Cytotoxicity:	0.001	Hek293 Cytotoxicity:	0.004
BCF:	0.318 ? Bioconcentration factors are used for considering secondary poisoning potential and assessing risks to human health via the food chain. The unit is -log10[(mg/L)/(1000*MW)].	IGC50:	2.767 ? 48 hour Tetrahymena pyriformis IGC50. The unit of IGC50 is -log10[(mg/L)/(1000*MW)].
LC50DM:	4.175 ? 48 hour Daphnia magna LC50. The unit of LC50DM is -log10[(mg/L)/(1000*MW)].	LC50FM:	3.645 ? 96 hour fathead minnow LC50. The unit of LC50FM is -log10[(mg/L)/(1000*MW)].

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO40573	Chryseobacterium indologenes 597	Strain	n.a.	Bacteria	n.a.	n.a.	n.a.	PMID[19651915]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	Organism Name	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
Ki	7
Ratio	11
Activity	115
IC50	54
Inhibition	4
AC50	73
MIC	692
MBC	32
ED50	3
MIC50	98
MIC90	99
FC	10
MBC90	1
EC50	1
IZ	4
Survival	2

Activity Type	# Activity
Individual protein	78
Cell line	1
Single protein	48
Organism	965
Tissue	1
Others	46
Non-molecular	65
Protein complex	2

Molecular-level activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT1237	Individual protein	Oligopeptide transporter small intestine isoform	Homo sapiens	Ki	=	26000000.0	nM	PMID[15974593]
NPT1037	Individual protein	Solute carrier family 15 member 2	Homo sapiens	Ki	=	12600000.0	nM	PMID[21741846]
NPT1037	Individual protein	Solute carrier family 15 member 2	Homo sapiens	Ki	=	12589254.12	nM	PMID[21741846]
NPT1241	Individual protein	Oligopeptide transporter, kidney isoform	Rattus norvegicus	Ki	>	3000.0	nM	PMID[15567297]
NPT1237	Individual protein	Oligopeptide transporter small intestine isoform	Homo sapiens	Ki	>	5000000.0	nM	PMID[15567297]
NPT1241	Individual protein	Oligopeptide transporter, kidney isoform	Rattus norvegicus	Ki	=	12600000.0	nM	PMID[15567297]
NPT1237	Individual protein	Oligopeptide transporter small intestine isoform	Homo sapiens	Ki	=	26000000.0	nM	PMID[15567297]
NPT218	Individual protein	Adenosine A3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT291	Individual protein	Serotonin 2b (5-HT2b) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT228	Individual protein	Norepinephrine transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT243	Individual protein	Dopamine D2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT217	Individual protein	Adenosine A2a receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT290	Individual protein	Serotonin 2a (5-HT2a) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT242	Individual protein	Dopamine D1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1788	Individual protein	Alpha-1a adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1464	Individual protein	Phosphodiesterase 4D	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1410	Individual protein	GABA receptor alpha-1 subunit	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT292	Individual protein	Serotonin 2c (5-HT2c) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT224	Individual protein	Alpha-2c adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT299	Individual protein	Androgen Receptor	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT272	Individual protein	Kappa opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT246	Individual protein	Dopamine transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT222	Individual protein	Alpha-2a adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1647	Individual protein	Vasopressin V2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT271	Individual protein	Delta opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT295	Individual protein	Serotonin transporter	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT108	Individual protein	Estrogen receptor alpha	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT249	Individual protein	Glucocorticoid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT252	Individual protein	Histamine H2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT216	Individual protein	Adenosine A1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT225	Individual protein	Beta-1 adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT1163	Individual protein	Glutamate (NMDA) receptor subunit zeta 1	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT261	Individual protein	Monoamine oxidase A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT264	Individual protein	Muscarinic acetylcholine receptor M3	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT232	Individual protein	Cannabinoid CB1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT145	Individual protein	Mu opioid receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT262	Individual protein	Muscarinic acetylcholine receptor M1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT263	Individual protein	Muscarinic acetylcholine receptor M2	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT244	Individual protein	Dopamine D3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT267	Individual protein	Neuropeptide Y receptor type 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT2879	Individual protein	Equilibrative nucleoside transporter 1	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT230	Individual protein	Bradykinin B2 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT31	Individual protein	Cyclooxygenase-2	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT239	Individual protein	Cholecystokinin A receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT251	Individual protein	Histamine H1 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT226	Individual protein	Beta-2 adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT223	Individual protein	Alpha-2b adrenergic receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT247	Individual protein	Endothelin receptor ET-A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT303	Individual protein	Vasopressin V1a receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT5575	Individual protein	Gil1	Citrobacter gillenii	Ratio	=	0.4	n.a.	PMID[17242148]
NPT26363	Single protein	Penicillin-binding protein 2x	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.004	ug.mL-1	PMID[19237649]
NPT26363	Single protein	Penicillin-binding protein 2x	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.003	ug.mL-1	PMID[19237649]
NPT26363	Single protein	Penicillin-binding protein 2x	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.02	ug.mL-1	PMID[19237649]
NPT26363	Single protein	Penicillin-binding protein 2x	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.014	ug.mL-1	PMID[19237649]
NPT26363	Single protein	Penicillin-binding protein 2x	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.00004	ug.mL-1	PMID[19237649]
NPT26363	Single protein	Penicillin-binding protein 2x	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.002	ug.mL-1	PMID[19237649]
NPT26363	Single protein	Penicillin-binding protein 2x	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.006	ug.mL-1	PMID[19237649]
NPT14749	Single protein	Penicillin-binding protein 2B	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.038	ug.mL-1	PMID[19237649]
NPT14749	Single protein	Penicillin-binding protein 2B	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.0005	ug.mL-1	PMID[19237649]
NPT14749	Single protein	Penicillin-binding protein 2B	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	2.646	ug.mL-1	PMID[19237649]
NPT14749	Single protein	Penicillin-binding protein 2B	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.472	ug.mL-1	PMID[19237649]
NPT14749	Single protein	Penicillin-binding protein 2B	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.023	ug.mL-1	PMID[19237649]
NPT14749	Single protein	Penicillin-binding protein 2B	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	14.74	ug.mL-1	PMID[19237649]
NPT14749	Single protein	Penicillin-binding protein 2B	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	1.656	ug.mL-1	PMID[19237649]
NPT14749	Single protein	Penicillin-binding protein 2B	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.171	ug.mL-1	PMID[19237649]
NPT14749	Single protein	Penicillin-binding protein 2B	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	1.164	ug.mL-1	PMID[19237649]
NPT713	Individual protein	Bile salt export pump	Homo sapiens	AC50	>	300000.0	nM	PMID[37468498]
NPT5301	Individual protein	Motilin receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT987	Individual protein	Histamine H3 receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT20556	Single protein	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	3.14	%	DOI[10.6019/CHEMBL4495564]
NPT4358	Individual protein	Type-1 angiotensin II receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT29430	Single protein	Neuronal acetylcholine receptor protein alpha-4 subunit	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT4729	Individual protein	Cholecystokinin B receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT98	Individual protein	HERG	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT99	Individual protein	Peroxisome proliferator-activated receptor gamma	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT542	Individual protein	Progesterone receptor	Homo sapiens	AC50	=	3900.0	nM	PMID[37468498]
NPT14748	Single protein	Penicillin-binding protein 1A	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.004	ug.mL-1	PMID[19237649]
NPT14748	Single protein	Penicillin-binding protein 1A	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.001	ug.mL-1	PMID[19237649]
NPT14748	Single protein	Penicillin-binding protein 1A	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.006	ug.mL-1	PMID[19237649]
NPT14748	Single protein	Penicillin-binding protein 1A	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.008	ug.mL-1	PMID[19237649]
NPT14748	Single protein	Penicillin-binding protein 1A	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.002	ug.mL-1	PMID[19237649]
NPT14748	Single protein	Penicillin-binding protein 1A	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.01	ug.mL-1	PMID[19237649]
NPT14748	Single protein	Penicillin-binding protein 1A	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	IC50	=	0.164	ug.mL-1	PMID[19237649]
NPT14802	Single protein	Extended spectrum beta-lactamase CTX-M-71	Klebsiella pneumoniae	Ratio	=	0.1	n.a.	PMID[19620330]
NPT28814	Single protein	Ghrelin receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT92	Individual protein	Serotonin 1a (5-HT1a) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT29454	Single protein	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	Homo sapiens	Inhibition	=	-10.74	%	PMID[38318365]
NPT5104	Individual protein	Phosphodiesterase 3A	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT5975	Individual protein	Cyclooxygenase-1	Rattus norvegicus	AC50	>	30000.0	nM	PMID[37468498]
NPT5577	Individual protein	Beta-lactamase	Bacillus clausii	Activity	=	2.0	n.a.	PMID[17846134]
NPT6272	Individual protein	PER-2 beta-lactamase	Citrobacter freundii	Activity	=	45.0	%	PMID[17438050]
NPT18177	Single protein	Catechol 2,3-dioxygenase	Stenotrophomonas maltophilia	Activity	=	4.0	U/min	PMID[20385866]
NPT18177	Single protein	Catechol 2,3-dioxygenase	Stenotrophomonas maltophilia	Activity	=	39.0	U/min	PMID[20385866]
NPT18177	Single protein	Catechol 2,3-dioxygenase	Stenotrophomonas maltophilia	Activity	=	41.0	U/min	PMID[20385866]
NPT18177	Single protein	Catechol 2,3-dioxygenase	Stenotrophomonas maltophilia	Activity	=	5.0	U/min	PMID[20385866]
NPT18177	Single protein	Catechol 2,3-dioxygenase	Stenotrophomonas maltophilia	Activity	=	0.0	U/min	PMID[20385866]
NPT18177	Single protein	Catechol 2,3-dioxygenase	Stenotrophomonas maltophilia	Activity	=	6.0	U/min	PMID[20385866]
NPT18177	Single protein	Catechol 2,3-dioxygenase	Stenotrophomonas maltophilia	Activity	=	50.0	U/min	PMID[20385866]
NPT18177	Single protein	Catechol 2,3-dioxygenase	Stenotrophomonas maltophilia	Activity	=	45.0	U/min	PMID[20385866]
NPT18177	Single protein	Catechol 2,3-dioxygenase	Stenotrophomonas maltophilia	Activity	=	8.0	U/min	PMID[20385866]
NPT14803	Single protein	Beta-lactamase AH27 CTX-M-15	Klebsiella pneumoniae	Ratio	=	0.25	n.a.	PMID[19620330]
NPT543	Individual protein	Pregnane X receptor	Homo sapiens	AC50	=	6100.0	nM	PMID[37468498]
NPT425	Individual protein	Serotonin 3a (5-HT3a) receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT543	Individual protein	Pregnane X receptor	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT30151	Single protein	Melanocortin receptor 3	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT543	Individual protein	Pregnane X receptor	Homo sapiens	AC50	=	12999.9	nM	PMID[37468498]

In vitro activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT857	Cell line	LLC-PK1	Sus scrofa	Ratio	=	2.0	n.a.	PMID[24397738]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.06	ug.mL-1	PMID[10230635]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.25	ug.mL-1	PMID[10230635]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	32.0	ug.mL-1	PMID[10230635]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	16.0	ug.mL-1	PMID[10230635]
NPT2916	Organism	Klebsiella	Klebsiella	MIC	=	3.71	ug.mL-1	PMID[3572964]
NPT2921	Organism	Pseudomonas	Pseudomonas	MIC	>	100.0	ug.mL-1	PMID[3572964]
NPT14695	Organism	Neisseria perflava	Neisseria perflava	MIC	=	0.39	ug.mL-1	PMID[3572964]
NPT174	Organism	Streptococcus	Streptococcus	MIC	=	15.14	ug.mL-1	PMID[3572964]
NPT6381	Organism	Sarcina	Sarcina	MIC	=	0.39	ug.mL-1	PMID[3572964]
NPT2916	Organism	Klebsiella	Klebsiella	MBC	=	4.68	ug ml-1	PMID[3572964]
NPT2921	Organism	Pseudomonas	Pseudomonas	MBC	>	100.0	ug ml-1	PMID[3572964]
NPT14695	Organism	Neisseria perflava	Neisseria perflava	MBC	=	0.78	ug ml-1	PMID[3572964]
NPT174	Organism	Streptococcus	Streptococcus	MBC	=	59.46	ug ml-1	PMID[3572964]
NPT6381	Organism	Sarcina	Sarcina	MBC	=	0.55	ug ml-1	PMID[3572964]
NPT566	Organism	Salmonella typhimurium	Salmonella enterica subsp. enterica serovar Typhimurium	ED50	>	90.0	mg.kg-1	PMID[3572964]
NPT566	Organism	Salmonella typhimurium	Salmonella enterica subsp. enterica serovar Typhimurium	MIC	=	1.56	ug.mL-1	PMID[3572964]
NPT1033	Organism	Enterobacter cloacae	Enterobacter cloacae	MIC	=	256.0	ug.mL-1	PMID[17116662]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	<=	0.016	ug.mL-1	PMID[17116666]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.03	ug.mL-1	PMID[17116666]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.125	ug.mL-1	PMID[17116666]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.5	ug.mL-1	PMID[17116666]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.25	ug.mL-1	PMID[17116666]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	2.0	ug.mL-1	PMID[17116666]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	16.0	ug.mL-1	PMID[17116666]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	1.0	ug.mL-1	PMID[17116681]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	8.0	ug.mL-1	PMID[17116681]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	0.5	ug.mL-1	PMID[17116681]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	256.0	ug.mL-1	PMID[17116681]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	1.0	ug.mL-1	PMID[17116681]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	0.5	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	1.0	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	0.25	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	1.0	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	0.5	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	2.0	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	4.0	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	<=	0.12	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	2.0	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	0.0	%	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	100.0	%	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	2.0	%	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	98.0	%	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	4.0	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	8.0	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	>=	2.0	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	>=	0.12	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	>=	0.5	ug.mL-1	PMID[17470649]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	0.5	ug.mL-1	PMID[17606681]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	<=	0.12	ug.mL-1	PMID[17606689]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	>=	4.0	ug.mL-1	PMID[17606689]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	<=	0.12	ug.mL-1	PMID[17606689]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	0.5	ug.mL-1	PMID[17606689]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	>	4.0	ug.mL-1	PMID[17606689]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	<=	0.12	ug.mL-1	PMID[17606689]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	4.0	ug.mL-1	PMID[17606689]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	>	4.0	ug.mL-1	PMID[17606689]
NPT1033	Organism	Enterobacter cloacae	Enterobacter cloacae	MIC	=	48.0	ug.mL-1	PMID[17638702]
NPT1033	Organism	Enterobacter cloacae	Enterobacter cloacae	MIC	>	256.0	ug.mL-1	PMID[17638702]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	1.0	ug.mL-1	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	2.0	ug.mL-1	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	64.0	ug.mL-1	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	2.0	ug.mL-1	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	16.0	ug.mL-1	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	128.0	ug.mL-1	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	97.7	%	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	66.3	%	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	1.4	%	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	1.2	%	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	21.4	%	PMID[17698631]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	94.6	%	PMID[17698631]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	78.2	%	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	99.9	%	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	74.0	%	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	0.0	%	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	18.7	%	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	12.7	%	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	99.2	%	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	<=	0.5	ug.mL-1	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	8.0	ug.mL-1	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	8.0	ug.mL-1	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	<=	0.5	ug.mL-1	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	4.0	ug.mL-1	PMID[17908940]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	16.0	ug.mL-1	PMID[17908940]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	1.0	ug.mL-1	PMID[17908940]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	2.0	ug.mL-1	PMID[17908940]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	97.6	%	PMID[17908940]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	96.3	%	PMID[17908940]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	98.0	%	PMID[17908940]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	0.3	%	PMID[17908940]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	0.7	%	PMID[17908940]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	0.2	%	PMID[17908940]
NPT172	Organism	Proteus mirabilis	Proteus mirabilis	MIC	>	16.0	ug.mL-1	PMID[18025117]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	13.3	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	2.0	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	8.0	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	8.0	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	16.0	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	32.0	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	9.3	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	6.0	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	11.4	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	2.0	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	32.0	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	6.5	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	4.0	ug.mL-1	PMID[19884366]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	8.0	ug.mL-1	PMID[19884366]
NPT1190	Organism	Salmonella enterica	Salmonella enterica	MIC	>	32.0	ug.mL-1	PMID[19901088]
NPT2895	Organism	Providencia stuartii	Providencia stuartii	MIC	=	1024.0	ug.mL-1	PMID[19901092]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.25	ug.mL-1	PMID[18160523]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.12	ug.mL-1	PMID[18160523]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	2.0	ug.mL-1	PMID[18160523]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	32.0	ug.mL-1	PMID[18160523]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	8.0	ug.mL-1	PMID[18160523]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	>	32.0	ug.mL-1	PMID[18160523]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	16.0	ug.mL-1	PMID[18160523]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	4.0	ug.mL-1	PMID[18160523]
NPT4805	Organism	Rhodococcus equi	Rhodococcus equi	MIC50	=	8.0	ug.mL-1	PMID[18227183]
NPT4805	Organism	Rhodococcus equi	Rhodococcus equi	MIC90	=	16.0	ug.mL-1	PMID[18227183]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	0.5	ug.mL-1	PMID[18347113]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	2.0	ug.mL-1	PMID[18347113]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	0.03	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	0.12	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	0.25	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	0.5	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	0.5	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	2.0	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	4.0	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	4.0	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	8.0	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	16.0	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	>	0.016	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.016	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.03	ug.mL-1	PMID[18362189]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	>	1.0	ug.mL-1	PMID[18362189]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	0.5	ug.mL-1	PMID[20086141]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	4.0	ug.mL-1	PMID[20086141]
NPT3988	Organism	Corynebacterium minutissimum	Corynebacterium minutissimum	MIC	=	0.25	ug.mL-1	PMID[18227183]
NPT4805	Organism	Rhodococcus equi	Rhodococcus equi	MIC	=	0.25	ug.mL-1	PMID[18227183]
NPT3988	Organism	Corynebacterium minutissimum	Corynebacterium minutissimum	MIC50	=	0.5	ug.mL-1	PMID[18227183]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	1.0	ug.mL-1	PMID[18955529]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	8.0	ug.mL-1	PMID[18955529]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	20.0	%	PMID[18955529]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	2.0	ug.mL-1	PMID[18955529]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	19.0	%	PMID[18955529]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	4.0	ug.mL-1	PMID[18955529]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	16.0	ug.mL-1	PMID[18955529]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	48.8	%	PMID[18955529]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	45.4	%	PMID[18955529]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	99.3	%	PMID[20439616]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	5.5	%	PMID[20439616]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	83.8	%	PMID[20439616]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	1.0	ug.mL-1	PMID[20439616]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	<=	0.015	ug.mL-1	PMID[20439616]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	94.5	%	PMID[20439616]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	1.3	%	PMID[20439616]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC50	=	0.5	ug.mL-1	PMID[20439616]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC90	=	1.0	ug.mL-1	PMID[20439616]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	99.3	%	PMID[20439616]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	0.1	%	PMID[20439616]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	Activity	=	91.4	%	PMID[20439616]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	0.0	%	PMID[18725443]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	0.25	ug.mL-1	PMID[18725443]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	4.0	ug.mL-1	PMID[18725443]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	8.0	ug.mL-1	PMID[18725443]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	8.0	ug.mL-1	PMID[18725443]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	16.0	ug.mL-1	PMID[18725443]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	16.0	ug.mL-1	PMID[18725443]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	26.8	%	PMID[18725443]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	55.3	%	PMID[18725443]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	>=	32.0	ug.mL-1	PMID[18725443]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	31.6	%	PMID[18725443]
NPT2897	Organism	Citrobacter freundii	Citrobacter freundii	MIC	>	512.0	ug.mL-1	PMID[18765691]
NPT566	Organism	Salmonella typhimurium	Salmonella enterica subsp. enterica serovar Typhimurium	MIC	=	4.0	ug.mL-1	PMID[18519732]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	2.0	%	PMID[18443122]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	17.0	%	PMID[18443122]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	1.0	ug.mL-1	PMID[18443122]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	>	4.0	ug.mL-1	PMID[18443122]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	>	4.0	ug.mL-1	PMID[18443122]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.5	ug.mL-1	PMID[18443122]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	2.0	ug.mL-1	PMID[18443122]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	4.0	ug.mL-1	PMID[18443122]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.016	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.125	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	2.0	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	4.0	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.03	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	1.0	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	16.0	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.5	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	8.0	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.25	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	64.0	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	32.0	ug.mL-1	PMID[19307366]
NPT5768	Organism	Acinetobacter pittii	Acinetobacter pittii	MIC	=	16.0	ug.mL-1	PMID[19029333]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	0.03	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	0.25	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	4.0	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	0.125	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	4.0	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	16.0	ug.mL-1	PMID[19307366]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	8.0	ug.mL-1	PMID[19307366]
NPT5768	Organism	Acinetobacter pittii	Acinetobacter pittii	MIC	=	24.0	ug.mL-1	PMID[19029333]
NPT5768	Organism	Acinetobacter pittii	Acinetobacter pittii	MIC	=	32.0	ug.mL-1	PMID[19029333]
NPT5768	Organism	Acinetobacter pittii	Acinetobacter pittii	MIC	=	48.0	ug.mL-1	PMID[19029333]
NPT5768	Organism	Acinetobacter pittii	Acinetobacter pittii	MIC	=	64.0	ug.mL-1	PMID[19029333]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	8.0	ug.mL-1	PMID[19237649]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	4.0	ug.mL-1	PMID[19237649]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	16.0	ug.mL-1	PMID[19237649]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	2.0	ug.mL-1	PMID[19237649]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.125	ug.mL-1	PMID[19237649]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.25	ug.mL-1	PMID[19237649]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	=	0.03	ug.mL-1	PMID[19237649]
NPT172	Organism	Proteus mirabilis	Proteus mirabilis	MIC	=	4.0	ug.mL-1	PMID[19258263]
NPT4074	Tissue	Serum	Homo sapiens	Activity	=	30.0	%	PMID[19223616]
NPT2910	Organism	Campylobacter jejuni	Campylobacter jejuni	MIC	=	128.0	ug.mL-1	PMID[19506058]
NPT2910	Organism	Campylobacter jejuni	Campylobacter jejuni	MIC	=	64.0	ug.mL-1	PMID[19506058]
NPT2910	Organism	Campylobacter jejuni	Campylobacter jejuni	MIC	=	256.0	ug.mL-1	PMID[19506058]
NPT2910	Organism	Campylobacter jejuni	Campylobacter jejuni	MIC50	=	128.0	ug.mL-1	PMID[19506058]
NPT2910	Organism	Campylobacter jejuni	Campylobacter jejuni	MIC90	=	128.0	ug.mL-1	PMID[19506058]
NPT2910	Organism	Campylobacter jejuni	Campylobacter jejuni	MIC	=	1.0	ug.mL-1	PMID[19506058]
NPT2910	Organism	Campylobacter jejuni	Campylobacter jejuni	MIC	=	32.0	ug.mL-1	PMID[19506058]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	36.1	%	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	2.0	ug.mL-1	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	4.0	ug.mL-1	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	=	4.0	ug.mL-1	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	=	8.0	ug.mL-1	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	<=	1.0	ug.mL-1	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC50	<=	1.0	ug.mL-1	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	<=	1.0	ug.mL-1	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC90	>	8.0	ug.mL-1	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	MIC	>	2.0	ug.mL-1	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	100.0	%	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	9.6	%	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	95.2	%	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	47.5	%	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	0.0	%	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	91.4	%	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	96.4	%	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	96.8	%	PMID[20308374]
NPT1118	Organism	Streptococcus pneumoniae	Streptococcus pneumoniae	Activity	=	20.7	%	PMID[20308374]
NPT4276	Organism	Yersinia enterocolitica	Yersinia enterocolitica	MIC	=	0.75	ug.mL-1	PMID[20547799]
NPT4276	Organism	Yersinia enterocolitica	Yersinia enterocolitica	MIC	=	0.5	ug.mL-1	PMID[20547799]
NPT729	Organism	Micrococcus luteus	Micrococcus luteus	MIC	=	0.98	ug.mL-1	PMID[22100136]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	0.5	ug.mL-1	PMID[22444877]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	0.5	ug.mL-1	PMID[22731783]
NPT729	Organism	Micrococcus luteus	Micrococcus luteus	MIC	=	0.98	ug.mL-1	PMID[23543889]
NPT729	Organism	Micrococcus luteus	Micrococcus luteus	MIC	=	0.49	ug.mL-1	PMID[23710121]
NPT1122	Organism	Haemophilus influenzae	Haemophilus influenzae	MIC	=	0.5	ug.mL-1	PMID[24953950]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	Inhibition	=	0.18	%	DOI[10.6019/CHEMBL4495565]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	20000.0	nM	DOI[10.6019/CHEMBL4651402]
NPT20555	Organism	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	IC50	>	19952.62	nM	DOI[10.6019/CHEMBL4651402]
NPT1228	Organism	Streptococcus pyogenes	Streptococcus pyogenes	MIC	=	0.06	ug.mL-1	PMID[10230635]
NPT1246	Organism	Salmonella	Salmonella	MIC	=	3.12	ug.mL-1	PMID[3572964]
NPT3496	Organism	Enterobacter	Enterobacter	MIC	=	7.01	ug.mL-1	PMID[3572964]
NPT1246	Organism	Salmonella	Salmonella	MBC	=	6.7	ug ml-1	PMID[3572964]
NPT3496	Organism	Enterobacter	Enterobacter	MBC	=	25.0	ug ml-1	PMID[3572964]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	ED50	=	9.0	mg.kg-1	PMID[3572964]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	=	12.5	ug.mL-1	PMID[3572964]
NPT1228	Organism	Streptococcus pyogenes	Streptococcus pyogenes	MIC	=	0.0313	ug.mL-1	PMID[17060524]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	2.0	ug.mL-1	PMID[17242148]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	>	512.0	ug.mL-1	PMID[17420213]
NPT14707	Organism	Bacillus clausii	Bacillus clausii	MIC	=	128000.0	ug.mL-1	PMID[17846134]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	MIC	=	16000.0	ug.mL-1	PMID[17846134]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	MIC	=	8000.0	ug.mL-1	PMID[17846134]
NPT5739	Organism	Enterobacteriaceae	Enterobacteriaceae	Activity	=	46.9	%	PMID[17452479]
NPT5739	Organism	Enterobacteriaceae	Enterobacteriaceae	Activity	=	21.9	%	PMID[17452479]
NPT1252	Organism	Streptococcus sp. 'group A'	Streptococcus sp. 'group A'	MIC	<=	0.12	ug.mL-1	PMID[17606689]
NPT1252	Organism	Streptococcus sp. 'group A'	Streptococcus sp. 'group A'	MIC50	<=	0.12	ug.mL-1	PMID[17606689]
NPT1252	Organism	Streptococcus sp. 'group A'	Streptococcus sp. 'group A'	MIC90	<=	0.12	ug.mL-1	PMID[17606689]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	=	1024.0	ug.mL-1	PMID[19901092]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	>	512.0	ug.mL-1	PMID[19917750]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	MIC50	>	32.0	ug.mL-1	PMID[18227183]
NPT5306	Organism	Corynebacterium amycolatum	Corynebacterium amycolatum	MIC90	=	2.0	ug.mL-1	PMID[18227183]
NPT5305	Organism	Corynebacterium jeikeium	Corynebacterium jeikeium	MIC90	>	32.0	ug.mL-1	PMID[18227183]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC90	=	0.25	ug.mL-1	PMID[18227183]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	MIC90	>	32.0	ug.mL-1	PMID[18227183]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	=	2.0	ug.mL-1	PMID[18316518]
NPT1252	Organism	Streptococcus sp. 'group A'	Streptococcus sp. 'group A'	MIC50	=	0.016	ug.mL-1	PMID[18362189]
NPT1252	Organism	Streptococcus sp. 'group A'	Streptococcus sp. 'group A'	MIC90	=	0.016	ug.mL-1	PMID[18362189]
NPT1252	Organism	Streptococcus sp. 'group A'	Streptococcus sp. 'group A'	MIC90	=	0.03	ug.mL-1	PMID[18362189]
NPT1252	Organism	Streptococcus sp. 'group A'	Streptococcus sp. 'group A'	MIC	=	0.016	ug.mL-1	PMID[18362189]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	64.0	ug.mL-1	PMID[18362192]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	>	64.0	ug.mL-1	PMID[18362192]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	>=	64.0	ug.mL-1	PMID[18426899]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	1.0	ug.mL-1	PMID[18268083]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	0.25	ug.mL-1	PMID[18268083]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	4.0	ug.mL-1	PMID[18268083]
NPT5306	Organism	Corynebacterium amycolatum	Corynebacterium amycolatum	MIC	=	0.125	ug.mL-1	PMID[18227183]
NPT5305	Organism	Corynebacterium jeikeium	Corynebacterium jeikeium	MIC	=	2.0	ug.mL-1	PMID[18227183]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	0.06	ug.mL-1	PMID[18227183]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	MIC	=	4.0	ug.mL-1	PMID[18227183]
NPT5306	Organism	Corynebacterium amycolatum	Corynebacterium amycolatum	MIC50	=	0.5	ug.mL-1	PMID[18227183]
NPT5305	Organism	Corynebacterium jeikeium	Corynebacterium jeikeium	MIC50	>	32.0	ug.mL-1	PMID[18227183]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC50	=	0.125	ug.mL-1	PMID[18227183]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	0.5	ug.mL-1	PMID[20308380]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	64.0	ug.mL-1	PMID[20308380]
NPT1228	Organism	Streptococcus pyogenes	Streptococcus pyogenes	MIC90	<=	0.015	ug.mL-1	PMID[20439616]
NPT1228	Organism	Streptococcus pyogenes	Streptococcus pyogenes	MIC50	<=	0.015	ug.mL-1	PMID[20439616]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	MIC	=	2.0	ug.mL-1	PMID[18765691]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	MIC	>	512.0	ug.mL-1	PMID[18765691]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	>=	64.0	ug.mL-1	PMID[20516281]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	16.0	ug.mL-1	PMID[20516281]
NPT6599	Organism	Pectobacterium atrosepticum	Pectobacterium atrosepticum	MIC	=	0.5	ug.mL-1	PMID[18443127]
NPT4066	Organism	Streptococcus mitis	Streptococcus mitis	MIC	<=	0.12	ug.mL-1	PMID[18443122]
NPT2710	Organism	Streptococcus agalactiae	Streptococcus agalactiae	MIC90	<=	0.12	ug.mL-1	PMID[18443122]
NPT2710	Organism	Streptococcus agalactiae	Streptococcus agalactiae	MIC50	<=	0.12	ug.mL-1	PMID[18443122]
NPT2710	Organism	Streptococcus agalactiae	Streptococcus agalactiae	MIC	<=	0.12	ug.mL-1	PMID[18443122]
NPT1228	Organism	Streptococcus pyogenes	Streptococcus pyogenes	MIC90	=	0.25	ug.mL-1	PMID[18443122]
NPT1228	Organism	Streptococcus pyogenes	Streptococcus pyogenes	MIC50	<=	0.12	ug.mL-1	PMID[18443122]
NPT1228	Organism	Streptococcus pyogenes	Streptococcus pyogenes	MIC	<=	0.12	ug.mL-1	PMID[18443122]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	>	256.0	ug.mL-1	PMID[19104021]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	>	256.0	ug.mL-1	PMID[19104021]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	0.125	ug.mL-1	PMID[19075048]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	0.25	ug.mL-1	PMID[19075048]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	=	0.5	ug.mL-1	PMID[19075048]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC90	=	0.25	ug.mL-1	PMID[19075048]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MBC	>	8.0	ug ml-1	PMID[19075048]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MBC	=	8.0	ug ml-1	PMID[19075048]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MBC	=	2.0	ug ml-1	PMID[19075048]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MBC	=	4.0	ug ml-1	PMID[19075048]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MBC90	>	8.0	ug ml-1	PMID[19075048]
NPT4077	Organism	Escherichia coli DH5[alpha]	Escherichia coli DH5[alpha]	MIC	=	0.25	ug.mL-1	PMID[19075050]
NPT4077	Organism	Escherichia coli DH5[alpha]	Escherichia coli DH5[alpha]	MIC	<=	0.125	ug.mL-1	PMID[19075050]
NPT4077	Organism	Escherichia coli DH5[alpha]	Escherichia coli DH5[alpha]	MIC	=	128.0	ug.mL-1	PMID[19075050]
NPT4077	Organism	Escherichia coli DH5[alpha]	Escherichia coli DH5[alpha]	MIC	=	64.0	ug.mL-1	PMID[19075050]
NPT5751	Organism	Burkholderia cenocepacia	Burkholderia cenocepacia	MIC	=	16.0	ug.mL-1	PMID[19075063]
NPT5751	Organism	Burkholderia cenocepacia	Burkholderia cenocepacia	MIC	=	512.0	ug.mL-1	PMID[19075063]
NPT5751	Organism	Burkholderia cenocepacia	Burkholderia cenocepacia	MIC	=	32.0	ug.mL-1	PMID[19075063]
NPT4077	Organism	Escherichia coli DH5[alpha]	Escherichia coli DH5[alpha]	MIC	=	1.5	ug.mL-1	PMID[19029333]
NPT4077	Organism	Escherichia coli DH5[alpha]	Escherichia coli DH5[alpha]	MIC	=	4.0	ug.mL-1	PMID[19029333]
NPT4077	Organism	Escherichia coli DH5[alpha]	Escherichia coli DH5[alpha]	MIC	=	32.0	ug.mL-1	PMID[19029333]
NPT4077	Organism	Escherichia coli DH5[alpha]	Escherichia coli DH5[alpha]	MIC	=	48.0	ug.mL-1	PMID[19029333]
NPT4077	Organism	Escherichia coli DH5[alpha]	Escherichia coli DH5[alpha]	MIC	=	64.0	ug.mL-1	PMID[19029333]
NPT4077	Organism	Escherichia coli DH5[alpha]	Escherichia coli DH5[alpha]	MIC	=	96.0	ug.mL-1	PMID[19029333]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	MIC	=	128.0	ug.mL-1	PMID[19414578]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	MIC	=	64.0	ug.mL-1	PMID[19414578]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	MIC	>	256.0	ug.mL-1	PMID[19414578]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	MIC	=	6.0	ug.mL-1	PMID[19414578]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	>	256.0	ug.mL-1	PMID[19770275]
NPT20529	Non-molecular	NON-PROTEIN TARGET	n.a.	MIC	>	256.0	ug.mL-1	PMID[20547808]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	MIC	=	2.0	ug.mL-1	PMID[19620330]
NPT1466	Organism	Escherichia coli K12	Escherichia coli K-12	MIC	=	256.0	ug.mL-1	PMID[19620330]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	>	512.0	ug.mL-1	PMID[19620330]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	IZ	=	21.1	mm	PMID[20713661]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	IZ	=	24.4	mm	PMID[20713661]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	MIC	=	2.87	ug.mL-1	PMID[20713661]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	MIC	=	1.44	ug.mL-1	PMID[20713661]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	FC	>	2.0	n.a.	PMID[20713661]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	FC	=	2.0	n.a.	PMID[20643901]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	MIC	=	2.87	ug.mL-1	PMID[20643901]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	MIC	=	1.44	ug.mL-1	PMID[20643901]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	IZ	=	21.3	mm	PMID[20643901]
NPT564	Organism	Listeria monocytogenes	Listeria monocytogenes	IZ	=	24.8	mm	PMID[20643901]
NPT79	Organism	Bacillus subtilis	Bacillus subtilis	MIC	=	15.63	ug.mL-1	PMID[22100136]
NPT5781	Organism	Bacillus cereus ATCC 10876	Bacillus cereus ATCC 10876	MIC	=	31.25	ug.mL-1	PMID[23543889]
NPT79	Organism	Bacillus subtilis	Bacillus subtilis	MIC	=	15.63	ug.mL-1	PMID[23543889]
NPT5781	Organism	Bacillus cereus ATCC 10876	Bacillus cereus ATCC 10876	MIC	=	62.5	ug.mL-1	PMID[23710121]
NPT2709	Organism	Bacillus subtilis subsp. subtilis str. 168	Bacillus subtilis subsp. subtilis str. 168	Ratio	=	0.306	n.a.	PMID[23539337]
NPT2709	Organism	Bacillus subtilis subsp. subtilis str. 168	Bacillus subtilis subsp. subtilis str. 168	MIC	=	20000.0	nM	PMID[23539337]
NPT29392	Protein complex	Gamma-aminobutyric acid receptor subunit alpha-1/alpha-2/beta-2/gamma-2	Homo sapiens	AC50	>	30000.0	nM	PMID[37468498]
NPT173	Organism	Klebsiella pneumoniae	Klebsiella pneumoniae	MIC	=	8.192	ug.mL-1	PMID[34865870]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	1.0	ug.mL-1	PMID[10230635]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	2.0	ug.mL-1	PMID[10230635]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.2	ug.mL-1	PMID[3572964]
NPT775	Organism	Proteus	Proteus	MIC	=	1.97	ug.mL-1	PMID[3572964]
NPT19	Organism	Escherichia coli	Escherichia coli	MBC	=	4.42	ug ml-1	PMID[3572964]
NPT775	Organism	Proteus	Proteus	MBC	=	3.9	ug ml-1	PMID[3572964]
NPT19	Organism	Escherichia coli	Escherichia coli	ED50	=	4.8	mg.kg-1	PMID[3572964]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[17116662]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[17116662]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[17220412]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[17220412]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	1024.0	ug.mL-1	PMID[17220412]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	16.0	ug.mL-1	PMID[17220412]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[17242148]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[17242148]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	32.0	ug.mL-1	PMID[17353248]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	1.0	ug.mL-1	PMID[17353248]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC50	>	16.0	ug.mL-1	PMID[17371815]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC90	>	16.0	ug.mL-1	PMID[17371815]
NPT19	Organism	Escherichia coli	Escherichia coli	Activity	=	100.0	%	PMID[17371815]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[17371815]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	256.0	ug.mL-1	PMID[17371815]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[17420213]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[17420213]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2000.0	ug.mL-1	PMID[17846134]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	500.0	ug.mL-1	PMID[17846134]
NPT5308	Organism	Streptococcus sp. group B	Streptococcus sp. group B	MIC	<=	0.12	ug.mL-1	PMID[17606689]
NPT5308	Organism	Streptococcus sp. group B	Streptococcus sp. group B	MIC50	<=	0.12	ug.mL-1	PMID[17606689]
NPT5308	Organism	Streptococcus sp. group B	Streptococcus sp. group B	MIC90	<=	0.12	ug.mL-1	PMID[17606689]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	512.0	ug.mL-1	PMID[17664321]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	128.0	ug.mL-1	PMID[17664321]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	1.0	ug.mL-1	PMID[17664321]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[17709463]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[17709463]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC	>	512.0	ug.mL-1	PMID[19884378]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	32.0	ug.mL-1	PMID[19884378]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	128.0	ug.mL-1	PMID[19884378]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[19884378]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[19901088]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	16.0	ug.mL-1	PMID[19901088]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[19901088]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	16.0	ug.mL-1	PMID[19901091]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	0.5	ug.mL-1	PMID[19901091]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	1024.0	ug.mL-1	PMID[19901092]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	512.0	ug.mL-1	PMID[19901092]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	1024.0	ug.mL-1	PMID[19901092]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[19901092]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	512.0	ug.mL-1	PMID[19917750]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[19917750]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[19917750]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>=	512.0	ug.mL-1	PMID[20065056]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[20065056]
NPT4067	Organism	Corynebacterium pseudodiphtheriticum	Corynebacterium pseudodiphtheriticum	MIC90	=	0.125	ug.mL-1	PMID[18227183]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[18316518]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[18316518]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[18362187]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	64.0	ug.mL-1	PMID[18362187]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	128.0	ug.mL-1	PMID[18362187]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[18362192]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[18362192]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>=	64.0	ug.mL-1	PMID[18426899]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	16.0	ug.mL-1	PMID[18426899]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	32.0	ug.mL-1	PMID[18443114]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	64.0	ug.mL-1	PMID[18443114]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	128.0	ug.mL-1	PMID[18443114]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>=	256.0	ug.mL-1	PMID[18443114]
NPT1521	Organism	Stenotrophomonas maltophilia	Stenotrophomonas maltophilia	MIC	=	2048.0	ug.mL-1	PMID[18086856]
NPT1521	Organism	Stenotrophomonas maltophilia	Stenotrophomonas maltophilia	MIC	=	1024.0	ug.mL-1	PMID[18086856]
NPT1521	Organism	Stenotrophomonas maltophilia	Stenotrophomonas maltophilia	Ratio	=	2.4	n.a.	PMID[18086856]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[18268083]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	0.5	ug.mL-1	PMID[18268083]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[18268083]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[18268083]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[18160517]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[18160517]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	32.0	ug.mL-1	PMID[18160517]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	128.0	ug.mL-1	PMID[18160517]
NPT4067	Organism	Corynebacterium pseudodiphtheriticum	Corynebacterium pseudodiphtheriticum	MIC	<=	0.03	ug.mL-1	PMID[18227183]
NPT4067	Organism	Corynebacterium pseudodiphtheriticum	Corynebacterium pseudodiphtheriticum	MIC50	=	0.06	ug.mL-1	PMID[18227183]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	0.5	ug.mL-1	PMID[20308380]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	256.0	ug.mL-1	PMID[20308380]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	1.0	ug.mL-1	PMID[20211890]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC90	=	1.0	ug.mL-1	PMID[20211890]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	16.0	ug.mL-1	PMID[19001117]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	1.0	ug.mL-1	PMID[19001117]
NPT1521	Organism	Stenotrophomonas maltophilia	Stenotrophomonas maltophilia	MIC	>	1024.0	ug.mL-1	PMID[20385866]
NPT1521	Organism	Stenotrophomonas maltophilia	Stenotrophomonas maltophilia	MIC	=	32.0	ug.mL-1	PMID[20385866]
NPT1521	Organism	Stenotrophomonas maltophilia	Stenotrophomonas maltophilia	MIC	=	64.0	ug.mL-1	PMID[20385866]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[18765691]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	512.0	ug.mL-1	PMID[18765691]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	256.0	ug.mL-1	PMID[18443127]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[18443127]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[18443121]
NPT5308	Organism	Streptococcus sp. group B	Streptococcus sp. group B	MIC	=	0.06	ug.mL-1	PMID[18541727]
NPT5308	Organism	Streptococcus sp. group B	Streptococcus sp. group B	MIC	=	0.03	ug.mL-1	PMID[18541727]
NPT5308	Organism	Streptococcus sp. group B	Streptococcus sp. group B	MIC	=	0.25	ug.mL-1	PMID[18541727]
NPT5308	Organism	Streptococcus sp. group B	Streptococcus sp. group B	MIC	=	0.12	ug.mL-1	PMID[18541727]
NPT5308	Organism	Streptococcus sp. group B	Streptococcus sp. group B	MIC	=	0.5	ug.mL-1	PMID[18541727]
NPT4401	Organism	Streptococcus oralis	Streptococcus oralis	MIC	<=	0.12	ug.mL-1	PMID[18443122]
NPT5315	Organism	Streptococcus intermedius	Streptococcus intermedius	MIC	<=	0.12	ug.mL-1	PMID[18443122]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	256.0	ug.mL-1	PMID[19104021]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[19104021]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	2.0	ug.mL-1	PMID[19075048]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	<=	0.125	ug.mL-1	PMID[19075050]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	16.0	ug.mL-1	PMID[19075063]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[19075063]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[19258263]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[19380596]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[19380596]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	FC	=	16.0	n.a.	PMID[19289525]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	FC	=	128.0	n.a.	PMID[19289525]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	FC	=	4.0	n.a.	PMID[19289525]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	EC50	=	0.27	ug.mL-1	PMID[19289525]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	Activity	=	0.26	mg/L	PMID[19289525]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	Activity	=	200.0	mg/L	PMID[19289525]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	2.0	ug.mL-1	PMID[19223616]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	FC	>	2.0	n.a.	PMID[19223616]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	FC	=	2.0	n.a.	PMID[19223616]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	256.0	ug.mL-1	PMID[19414578]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	96.0	ug.mL-1	PMID[19414578]
NPT1521	Organism	Stenotrophomonas maltophilia	Stenotrophomonas maltophilia	MIC	=	2048.0	ug.mL-1	PMID[19414581]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[19770275]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	256.0	ug.mL-1	PMID[19770275]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	32.0	ug.mL-1	PMID[19651915]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[19651915]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	256.0	ug.mL-1	PMID[20547808]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	64.0	ug.mL-1	PMID[20547808]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	128.0	ug.mL-1	PMID[20547808]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[20547808]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	512.0	ug.mL-1	PMID[19470510]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[19470510]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[19620330]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	512.0	ug.mL-1	PMID[19620330]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	512.0	ug.mL-1	PMID[19620330]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[19001114]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	256.0	ug.mL-1	PMID[19001114]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	32.0	ug.mL-1	PMID[19001114]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	128.0	ug.mL-1	PMID[19001114]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	96.0	ug.mL-1	PMID[19001114]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	256.0	ug.mL-1	PMID[19001114]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	2.0	ug.mL-1	PMID[19001114]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	256.0	ug.mL-1	PMID[20498317]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	8.0	ug.mL-1	PMID[20498317]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	64.0	ug.mL-1	PMID[21041509]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	128.0	ug.mL-1	PMID[21041509]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	4.0	ug.mL-1	PMID[21041509]
NPT19	Organism	Escherichia coli	Escherichia coli	Activity	=	0.0	%	PMID[20733038]
NPT19	Organism	Escherichia coli	Escherichia coli	Activity	=	1.1	%	PMID[20733038]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	128.0	ug.mL-1	PMID[20733047]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	512.0	ug.mL-1	PMID[20733047]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	256.0	ug.mL-1	PMID[20733047]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	1.0	ug.mL-1	PMID[20733047]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	>	512.0	ug.mL-1	PMID[20733047]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	32.0	ug.mL-1	PMID[20733047]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	0.49	ug.mL-1	PMID[22100136]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	0.98	ug.mL-1	PMID[22100136]
NPT19	Organism	Escherichia coli	Escherichia coli	Ratio	=	16.0	n.a.	PMID[22483632]
NPT19	Organism	Escherichia coli	Escherichia coli	Ratio	=	8.0	n.a.	PMID[22483632]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	1.56	ug.mL-1	PMID[22483632]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	0.49	ug.mL-1	PMID[23543889]
NPT3145	Organism	Bacillus subtilis subsp. spizizenii ATCC 6633	Bacillus subtilis subsp. spizizenii ATCC 6633	MIC	=	0.49	ug.mL-1	PMID[23710121]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	1.95	ug.mL-1	PMID[23710121]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	0.49	ug.mL-1	PMID[23710121]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	500.0	ug.mL-1	PMID[26186150]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	2.0	ug.mL-1	PMID[28992569]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	>	128.0	ug.mL-1	PMID[28992569]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	8.0	ug.mL-1	PMID[28992569]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	1.0	ug.mL-1	PMID[28992569]
NPT4025	Organism	Staphylococcus hominis	Staphylococcus hominis	MIC	=	8.0	ug.mL-1	PMID[28992569]
NPT17	Organism	Staphylococcus epidermidis	Staphylococcus epidermidis	MIC	=	32.0	ug.mL-1	PMID[28992569]
NPT17	Organism	Staphylococcus epidermidis	Staphylococcus epidermidis	MIC	=	0.5	ug.mL-1	PMID[28992569]
NPT175	Organism	Enterococcus faecalis	Enterococcus faecalis	MIC	>	128.0	ug.mL-1	PMID[28992569]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	32.0	ug.mL-1	PMID[30503946]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	1024.0	ug.mL-1	PMID[30503946]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	256.0	ug.mL-1	PMID[30503946]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	16.0	ug.mL-1	PMID[30503946]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	512.0	ug.mL-1	PMID[30503946]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	64.0	ug.mL-1	PMID[30503946]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	8.0	ug.mL-1	PMID[30503946]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	MIC	=	2.0	ug.mL-1	PMID[30503946]
NPT16	Organism	Staphylococcus aureus	Staphylococcus aureus	Activity	=	70.0	%	PMID[30503946]
NPT18	Organism	Pseudomonas aeruginosa	Pseudomonas aeruginosa	MIC	=	98.0	ug.mL-1	PMID[32971428]
NPT19	Organism	Escherichia coli	Escherichia coli	MIC	=	1.024	ug.mL-1	PMID[34865870]
NPT2	Others	Unspecified	n.a.	MIC	=	10.64	ug.mL-1	PMID[3572964]
NPT2	Others	Unspecified	n.a.	MIC	=	1.11	ug.mL-1	PMID[3572964]
NPT2917	Organism	Serratia	Serratia	MIC	=	12.4	ug.mL-1	PMID[3572964]
NPT23986	Organism	Alcaligenes	Alcaligenes	MIC	=	50.0	ug.mL-1	PMID[3572964]
NPT1238	Organism	Staphylococcus	Staphylococcus	MIC	=	1.06	ug.mL-1	PMID[3572964]
NPT1238	Organism	Staphylococcus	Staphylococcus	MIC	=	10.51	ug.mL-1	PMID[3572964]
NPT3598	Organism	Bacillus	Bacillus	MIC	=	35.36	ug.mL-1	PMID[3572964]
NPT2917	Organism	Serratia	Serratia	MBC	=	28.02	ug ml-1	PMID[3572964]
NPT23986	Organism	Alcaligenes	Alcaligenes	MBC	=	100.0	ug ml-1	PMID[3572964]
NPT1238	Organism	Staphylococcus	Staphylococcus	MBC	=	1.67	ug ml-1	PMID[3572964]
NPT1238	Organism	Staphylococcus	Staphylococcus	MBC	=	17.68	ug ml-1	PMID[3572964]
NPT3598	Organism	Bacillus	Bacillus	MBC	=	35.36	ug ml-1	PMID[3572964]
NPT2	Others	Unspecified	n.a.	Ratio	=	0.08	/mM/s	PMID[17420213]
NPT2	Others	Unspecified	n.a.	FC	=	100.0	n.a.	PMID[17846134]
NPT3843	Organism	Streptococcus viridans	Streptococcus viridans	MIC	<=	0.12	ug.mL-1	PMID[17606689]
NPT3843	Organism	Streptococcus viridans	Streptococcus viridans	MIC50	<=	0.12	ug.mL-1	PMID[17606689]
NPT3843	Organism	Streptococcus viridans	Streptococcus viridans	MIC90	=	2.0	ug.mL-1	PMID[17606689]
NPT2	Others	Unspecified	n.a.	Ratio	=	4.0	n.a.	PMID[17709463]
NPT1121	Organism	Moraxella catarrhalis	Moraxella catarrhalis	MIC50	=	1.0	ug.mL-1	PMID[17908940]
NPT1121	Organism	Moraxella catarrhalis	Moraxella catarrhalis	MIC90	=	2.0	ug.mL-1	PMID[17908940]
NPT747	Organism	Acinetobacter baumannii	Acinetobacter baumannii	MIC	>	256.0	ug.mL-1	PMID[19884362]
NPT2	Others	Unspecified	n.a.	Ratio	=	300.0	n.a.	PMID[19884378]
NPT1209	Organism	Pseudomonas fluorescens	Pseudomonas fluorescens	MIC	>	256.0	ug.mL-1	PMID[19901091]
NPT4843	Organism	Corynebacterium striatum	Corynebacterium striatum	MIC90	=	2.0	ug.mL-1	PMID[18227183]
NPT5744	Organism	Corynebacterium urealyticum	Corynebacterium urealyticum	MIC90	>	32.0	ug.mL-1	PMID[18227183]
NPT2	Others	Unspecified	n.a.	Activity	=	0.005	%	PMID[18212108]
NPT4843	Organism	Corynebacterium striatum	Corynebacterium striatum	MIC	=	0.125	ug.mL-1	PMID[18227183]
NPT5744	Organism	Corynebacterium urealyticum	Corynebacterium urealyticum	MIC	=	4.0	ug.mL-1	PMID[18227183]
NPT3987	Organism	Corynebacterium xerosis	Corynebacterium xerosis	MIC	=	0.125	ug.mL-1	PMID[18227183]
NPT4843	Organism	Corynebacterium striatum	Corynebacterium striatum	MIC50	=	1.0	ug.mL-1	PMID[18227183]
NPT5744	Organism	Corynebacterium urealyticum	Corynebacterium urealyticum	MIC50	>	32.0	ug.mL-1	PMID[18227183]
NPT3987	Organism	Corynebacterium xerosis	Corynebacterium xerosis	MIC50	=	2.0	ug.mL-1	PMID[18227183]
NPT2	Others	Unspecified	n.a.	Activity	=	1522.0	U/mg	PMID[20385866]
NPT2	Others	Unspecified	n.a.	Activity	=	5.0	U/mg	PMID[20385866]
NPT2	Others	Unspecified	n.a.	Activity	=	6.0	U/mg	PMID[20385866]
NPT2	Others	Unspecified	n.a.	Activity	=	3.0	U/mg	PMID[20385866]
NPT2	Others	Unspecified	n.a.	Activity	=	1735.0	U/mg	PMID[20385866]
NPT2	Others	Unspecified	n.a.	Activity	=	1615.0	U/mg	PMID[20385866]
NPT2	Others	Unspecified	n.a.	Activity	=	18.0	U/mg	PMID[20385866]
NPT2	Others	Unspecified	n.a.	Activity	=	1453.0	U/mg	PMID[20385866]
NPT2	Others	Unspecified	n.a.	Activity	=	12.0	U/mg	PMID[20385866]
NPT2	Others	Unspecified	n.a.	Activity	=	882.0	U/mg	PMID[20385866]
NPT747	Organism	Acinetobacter baumannii	Acinetobacter baumannii	MIC	>	128.0	ug.mL-1	PMID[18443121]
NPT747	Organism	Acinetobacter baumannii	Acinetobacter baumannii	MIC	=	32.0	ug.mL-1	PMID[18443121]
NPT3843	Organism	Streptococcus viridans	Streptococcus viridans	MIC	<=	0.12	ug.mL-1	PMID[18443122]
NPT5314	Organism	Streptococcus constellatus	Streptococcus constellatus	MIC	<=	0.12	ug.mL-1	PMID[18443122]
NPT2	Others	Unspecified	n.a.	IC50	=	0.923	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.032	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.028	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.038	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.075	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.016	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.024	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.008	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.198	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.002	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.01	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.011	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.009	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.004	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.048	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.023	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.047	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.021	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	IC50	=	0.071	ug.mL-1	PMID[19237649]
NPT2	Others	Unspecified	n.a.	Activity	<	0.01	%	PMID[19380596]
NPT4815	Organism	Neisseria meningitidis	Neisseria meningitidis	MIC	<	0.016	ug.mL-1	PMID[19188396]
NPT4815	Organism	Neisseria meningitidis	Neisseria meningitidis	MIC50	=	0.047	ug.mL-1	PMID[19188396]
NPT4815	Organism	Neisseria meningitidis	Neisseria meningitidis	MIC90	=	0.094	ug.mL-1	PMID[19188396]
NPT4815	Organism	Neisseria meningitidis	Neisseria meningitidis	Activity	=	99.0	%	PMID[19188396]
NPT4815	Organism	Neisseria meningitidis	Neisseria meningitidis	Activity	=	1.0	%	PMID[19188396]
NPT4815	Organism	Neisseria meningitidis	Neisseria meningitidis	Activity	=	0.0	%	PMID[19188396]
NPT4806	Organism	Campylobacter coli	Campylobacter coli	MIC	=	64.0	ug.mL-1	PMID[19506058]
NPT6330	Organism	Chryseobacterium indologenes	Chryseobacterium indologenes	MIC	>=	64.0	ug.mL-1	PMID[19651915]
NPT747	Organism	Acinetobacter baumannii	Acinetobacter baumannii	MIC	>	256.0	ug.mL-1	PMID[20547808]
NPT747	Organism	Acinetobacter baumannii	Acinetobacter baumannii	MIC	=	32.0	ug.mL-1	PMID[20547808]
NPT4806	Organism	Campylobacter coli	Campylobacter coli	MIC50	=	128.0	ug.mL-1	PMID[19506058]
NPT4806	Organism	Campylobacter coli	Campylobacter coli	MIC90	=	256.0	ug.mL-1	PMID[19506058]
NPT1277	Organism	Staphylococcus epidermidis ATCC 12228	Staphylococcus epidermidis ATCC 12228	MIC	=	0.24	ug.mL-1	PMID[22100136]
NPT314	Organism	Bacillus cereus	Bacillus cereus	MIC	=	31.25	ug.mL-1	PMID[22100136]
NPT1277	Organism	Staphylococcus epidermidis ATCC 12228	Staphylococcus epidermidis ATCC 12228	MIC	=	0.24	ug.mL-1	PMID[23543889]
NPT1277	Organism	Staphylococcus epidermidis ATCC 12228	Staphylococcus epidermidis ATCC 12228	MIC	=	0.24	ug.mL-1	PMID[23710121]
NPT1238	Organism	Staphylococcus	Staphylococcus	MIC	=	600.0	ug.mL-1	PMID[26186150]
NPT1843	Organism	Aeromonas hydrophila	Aeromonas hydrophila	MIC	=	500.0	ug.mL-1	PMID[26186150]
NPT1531	Organism	Enterococcus faecium	Enterococcus faecium	MIC	>	128.0	ug.mL-1	PMID[28992569]

In vivo activity

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	91.4	%	PMID[17145792]
NPT32	Organism	Mus musculus	Mus musculus	Survival	=	5.0	%	PMID[17145792]
NPT605	Organism	Homo sapiens	Homo sapiens	Activity	=	1.0	%	PMID[20022146]

Experimental ADME

Experiment Model	Experiment Tissue	ADME Type	ADME Relation	ADME Value	ADME Unit	Reference
n.a.	n.a.	permeability	=	0.6	10^-6 cm/s	PMID[36996715]

Experimental Toxicity

Quantitative toxicity

Experiment Model	Experiment Organism	Toxicity Type	Toxicity Relation	Toxicity Value	Toxicity Unit	Reference

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity	Carcinogenicity	Mutagenicity	Cardiotoxicity	Respiratory Toxicity	Eye Irritation	Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]

Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

● The left chart: Distribution of similarity level between NPC487961 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	23454
0.1-0.2	26284
0.2-0.3	105
0.3-0.4	4
0.4-0.5	8
0.5-0.6	3
0.6-0.7	0
0.7-0.8	2
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Natural Product ID
0.561	Remote Similarity	NPC487959
0.5465	Remote Similarity	NPC478434
0.5349	Remote Similarity	NPC487968

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC487961 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

range	Tanimoto Coefficient
0-0.1	3583
0.1-0.2	5292
0.2-0.3	150
0.3-0.4	86
0.4-0.5	30
0.5-0.6	4
0.6-0.7	2
0.7-0.8	2
0.8-0.85	0
0.85-0.9	0
0.9-0.95	0
0.95-1	1

Similarity Score	Similarity Level	Drug ID	Developmental Stage
1.0	High Similarity	NPD1986	Phase 4
0.7436	Intermediate Similarity	NPD1985	Approved
0.7436	Intermediate Similarity	NPD1987	Approved
0.625	Remote Similarity	NPD3291	Phase 2
0.6235	Remote Similarity	NPD3958	Phase 4
0.5663	Remote Similarity	NPD1665	Phase 4
0.561	Remote Similarity	NPD1979	Phase 4
0.5465	Remote Similarity	NPD2025	Phase 4
0.5349	Remote Similarity	NPD2020	Phase 4

Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data