Natural Product: NPC304509

Natural Product ID:  NPC304509
Common Name:   Dendronpholide G
IUPAC Name:  
Synonyms:   Dendronpholide G
Molecular Formula:   C23H36O7
Standard InCHIKey:  AVJJAJDAJIWWOI-VSMZHHACSA-N
Standard InCHI:  InChI=1S/C23H36O7/c1-14(20(25)27-6)16-7-10-21(3,26)17-8-11-22(4,29-17)18(28-15(2)24)9-12-23(5)19(13-16)30-23/h16-19,26H,1,7-13H2,2-6H3/t16-,17+,18+,19+,21-,22-,23+/m1/s1
Canonical SMILES:  COC(=O)C(=C)[C@@H]1CC[C@@](C)(O)[C@@H]2CC[C@@](O2)([C@H](CC[C@]2([C@H](C1)O2)C)OC(=O)C)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO3286 Erythrina americana Species Fabaceae Eukaryota UNPD*
NPO7475 Sinularia querciformis Species Alcyoniidae Eukaryota UNPD*
NPO10949 Riccardia multifida Species Aneuraceae Eukaryota UNPD*
NPO2735 Orthodon hirtus Species Cyprinidae Eukaryota UNPD*
NPO3048 Laportea moroides Species Urticaceae Eukaryota UNPD*
NPO4491 Aplophyllum cappadocicum NA NA NA UNPD*
NPO5448 Wattakaka volubilis Species Apocynaceae Eukaryota UNPD*
NPO9011 Anaptychia neoleucomelaena Species Physciaceae Eukaryota UNPD*
NPO6712 Artocarpus scortechinii Species Moraceae Eukaryota UNPD*
NPO33216 dendronephthya sp. Species Nephtheidae Eukaryota China PMID[18563933]
NPO7724 Heterobasidion annosum Species Bondarzewiaceae Eukaryota UNPD*
NPO14948 Brucea javanica Species Simaroubaceae Eukaryota UNPD*
NPO11440 Dictyota menstrualis Species Dictyotaceae Eukaryota UNPD*
NPO10200 Pourouma cecropiifolia Species Urticaceae Eukaryota UNPD*
NPO3371 Podocarpus nubigenus Species Podocarpaceae Eukaryota UNPD*
NPO232 Cayaponia racemosa Species Cucurbitaceae Eukaryota UNPD*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT2 Others Unspecified IC50 = 0.02 ug/ml 18563933

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC304509 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC47958
1.0 High Similarity NPC149725
0.939 High Similarity NPC475019
0.939 High Similarity NPC474949
0.939 High Similarity NPC476015
0.939 High Similarity NPC474762
0.9383 High Similarity NPC474780
0.9268 High Similarity NPC329749
0.9259 High Similarity NPC257358
0.9259 High Similarity NPC474472
0.9167 High Similarity NPC177629
0.9167 High Similarity NPC58219
0.9146 High Similarity NPC475963
0.9146 High Similarity NPC151176
0.9146 High Similarity NPC3464
0.9059 High Similarity NPC307411
0.9059 High Similarity NPC92974
0.9048 High Similarity NPC186148
0.8966 High Similarity NPC212486
0.8953 High Similarity NPC51004
0.8889 High Similarity NPC474981
0.8864 High Similarity NPC474035
0.8864 High Similarity NPC81386
0.8851 High Similarity NPC30515
0.8851 High Similarity NPC70251
0.8851 High Similarity NPC475881
0.8851 High Similarity NPC184463
0.8837 High Similarity NPC474951
0.8824 High Similarity NPC5130
0.8764 High Similarity NPC14961
0.8764 High Similarity NPC270013
0.875 High Similarity NPC476300
0.8736 High Similarity NPC474761
0.8736 High Similarity NPC476004
0.8721 High Similarity NPC202672
0.8721 High Similarity NPC281516
0.8706 High Similarity NPC470242
0.8667 High Similarity NPC476315
0.8636 High Similarity NPC12172
0.8636 High Similarity NPC208886
0.8621 High Similarity NPC173926
0.8605 High Similarity NPC231889
0.8605 High Similarity NPC248602
0.8571 High Similarity NPC11620
0.8556 High Similarity NPC475900
0.8556 High Similarity NPC36954
0.8539 High Similarity NPC475912
0.8539 High Similarity NPC81419
0.8539 High Similarity NPC179746
0.8523 High Similarity NPC475748
0.8478 Intermediate Similarity NPC474213
0.8471 Intermediate Similarity NPC72464
0.8462 Intermediate Similarity NPC39859
0.8462 Intermediate Similarity NPC158416
0.8462 Intermediate Similarity NPC76862
0.8462 Intermediate Similarity NPC470883
0.8462 Intermediate Similarity NPC31645
0.8444 Intermediate Similarity NPC190294
0.8427 Intermediate Similarity NPC329952
0.8409 Intermediate Similarity NPC151770
0.8391 Intermediate Similarity NPC190753
0.8387 Intermediate Similarity NPC186861
0.8372 Intermediate Similarity NPC137033
0.837 Intermediate Similarity NPC328562
0.837 Intermediate Similarity NPC323421
0.8353 Intermediate Similarity NPC272814
0.8352 Intermediate Similarity NPC475659
0.8315 Intermediate Similarity NPC206614
0.8315 Intermediate Similarity NPC474323
0.8298 Intermediate Similarity NPC476270
0.8295 Intermediate Similarity NPC474471
0.8295 Intermediate Similarity NPC153805
0.8295 Intermediate Similarity NPC227379
0.828 Intermediate Similarity NPC473326
0.8261 Intermediate Similarity NPC476009
0.8261 Intermediate Similarity NPC473859
0.8256 Intermediate Similarity NPC138647
0.8256 Intermediate Similarity NPC470238
0.8256 Intermediate Similarity NPC9868
0.8242 Intermediate Similarity NPC57405
0.8242 Intermediate Similarity NPC303942
0.8191 Intermediate Similarity NPC471381
0.8191 Intermediate Similarity NPC288876
0.8182 Intermediate Similarity NPC118601
0.8172 Intermediate Similarity NPC471150
0.8152 Intermediate Similarity NPC476053
0.8111 Intermediate Similarity NPC65359
0.8105 Intermediate Similarity NPC15993
0.8105 Intermediate Similarity NPC201718
0.809 Intermediate Similarity NPC476704
0.809 Intermediate Similarity NPC178875
0.8068 Intermediate Similarity NPC164393
0.8068 Intermediate Similarity NPC162071
0.8068 Intermediate Similarity NPC122502
0.8065 Intermediate Similarity NPC279621
0.8043 Intermediate Similarity NPC473316
0.8043 Intermediate Similarity NPC473330
0.8041 Intermediate Similarity NPC474741
0.8022 Intermediate Similarity NPC469627
0.8021 Intermediate Similarity NPC324017
0.8021 Intermediate Similarity NPC320019
0.8 Intermediate Similarity NPC474032
0.8 Intermediate Similarity NPC233377
0.8 Intermediate Similarity NPC166919
0.7978 Intermediate Similarity NPC474765
0.7978 Intermediate Similarity NPC475703
0.7959 Intermediate Similarity NPC243998
0.7959 Intermediate Similarity NPC54737
0.7959 Intermediate Similarity NPC223450
0.7957 Intermediate Similarity NPC471141
0.7957 Intermediate Similarity NPC107476
0.7955 Intermediate Similarity NPC38468
0.7955 Intermediate Similarity NPC21469
0.7955 Intermediate Similarity NPC319795
0.7955 Intermediate Similarity NPC50362
0.7935 Intermediate Similarity NPC475838
0.7935 Intermediate Similarity NPC125674
0.7935 Intermediate Similarity NPC228451
0.7931 Intermediate Similarity NPC170377
0.7917 Intermediate Similarity NPC164598
0.7917 Intermediate Similarity NPC474339
0.7917 Intermediate Similarity NPC473332
0.7917 Intermediate Similarity NPC47880
0.7912 Intermediate Similarity NPC329857
0.7912 Intermediate Similarity NPC469718
0.7912 Intermediate Similarity NPC473619
0.7912 Intermediate Similarity NPC473448
0.7895 Intermediate Similarity NPC45125
0.7882 Intermediate Similarity NPC19841
0.7879 Intermediate Similarity NPC477513
0.7865 Intermediate Similarity NPC469676
0.7865 Intermediate Similarity NPC50637
0.7849 Intermediate Similarity NPC471147
0.7849 Intermediate Similarity NPC474247
0.7849 Intermediate Similarity NPC71589
0.7841 Intermediate Similarity NPC243618
0.7841 Intermediate Similarity NPC70424
0.7835 Intermediate Similarity NPC474747
0.7835 Intermediate Similarity NPC471148
0.7835 Intermediate Similarity NPC149371
0.7831 Intermediate Similarity NPC217725
0.7826 Intermediate Similarity NPC20713
0.7826 Intermediate Similarity NPC470373
0.7826 Intermediate Similarity NPC470379
0.7826 Intermediate Similarity NPC473321
0.7826 Intermediate Similarity NPC155215
0.7816 Intermediate Similarity NPC103171
0.7812 Intermediate Similarity NPC475949
0.7802 Intermediate Similarity NPC295312
0.7789 Intermediate Similarity NPC40812
0.7789 Intermediate Similarity NPC474313
0.7778 Intermediate Similarity NPC270270
0.7766 Intermediate Similarity NPC474947
0.7766 Intermediate Similarity NPC472873
0.7766 Intermediate Similarity NPC163228
0.7755 Intermediate Similarity NPC475871
0.7755 Intermediate Similarity NPC472755
0.7755 Intermediate Similarity NPC475945
0.7753 Intermediate Similarity NPC100921
0.7753 Intermediate Similarity NPC197903
0.7753 Intermediate Similarity NPC474547
0.7753 Intermediate Similarity NPC99395
0.7753 Intermediate Similarity NPC477018
0.7742 Intermediate Similarity NPC295204
0.7742 Intermediate Similarity NPC288240
0.7742 Intermediate Similarity NPC258216
0.7742 Intermediate Similarity NPC162205
0.7742 Intermediate Similarity NPC273579
0.7742 Intermediate Similarity NPC135776
0.7742 Intermediate Similarity NPC153590
0.7732 Intermediate Similarity NPC474742
0.7732 Intermediate Similarity NPC472753
0.7727 Intermediate Similarity NPC250315
0.7727 Intermediate Similarity NPC128429
0.7723 Intermediate Similarity NPC59489
0.7723 Intermediate Similarity NPC139838
0.7717 Intermediate Similarity NPC49342
0.7717 Intermediate Similarity NPC251385
0.7717 Intermediate Similarity NPC312042
0.7717 Intermediate Similarity NPC62815
0.7708 Intermediate Similarity NPC83895
0.7708 Intermediate Similarity NPC187761
0.7708 Intermediate Similarity NPC279561
0.7708 Intermediate Similarity NPC222303
0.7708 Intermediate Similarity NPC187268
0.7708 Intermediate Similarity NPC471144
0.7701 Intermediate Similarity NPC141810
0.7692 Intermediate Similarity NPC89001
0.7692 Intermediate Similarity NPC476707
0.7692 Intermediate Similarity NPC476706
0.7692 Intermediate Similarity NPC79549
0.7692 Intermediate Similarity NPC207114
0.7692 Intermediate Similarity NPC473715
0.7692 Intermediate Similarity NPC217983
0.7684 Intermediate Similarity NPC230800
0.7677 Intermediate Similarity NPC100487
0.7674 Intermediate Similarity NPC617
0.7667 Intermediate Similarity NPC475491
0.7667 Intermediate Similarity NPC112685
0.7667 Intermediate Similarity NPC469626

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC304509 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7955 Intermediate Similarity NPD1733 Clinical (unspecified phase)
0.7912 Intermediate Similarity NPD46 Approved
0.7912 Intermediate Similarity NPD6698 Approved
0.7527 Intermediate Similarity NPD7838 Discovery
0.7353 Intermediate Similarity NPD7899 Clinical (unspecified phase)
0.7263 Intermediate Similarity NPD7983 Approved
0.7234 Intermediate Similarity NPD1695 Approved
0.7143 Intermediate Similarity NPD6371 Approved
0.6952 Remote Similarity NPD6686 Approved
0.6869 Remote Similarity NPD1698 Clinical (unspecified phase)
0.6863 Remote Similarity NPD5344 Discontinued
0.6759 Remote Similarity NPD8413 Clinical (unspecified phase)
0.6729 Remote Similarity NPD4061 Clinical (unspecified phase)
0.6667 Remote Similarity NPD8029 Clinical (unspecified phase)
0.6667 Remote Similarity NPD6435 Approved
0.6636 Remote Similarity NPD5345 Clinical (unspecified phase)
0.6602 Remote Similarity NPD6648 Approved
0.6545 Remote Similarity NPD6053 Discontinued
0.6514 Remote Similarity NPD5955 Clinical (unspecified phase)
0.65 Remote Similarity NPD5778 Approved
0.65 Remote Similarity NPD5779 Approved
0.6486 Remote Similarity NPD8133 Approved
0.6452 Remote Similarity NPD5368 Approved
0.6429 Remote Similarity NPD7909 Approved
0.6421 Remote Similarity NPD7154 Phase 3
0.6379 Remote Similarity NPD8513 Phase 3
0.6379 Remote Similarity NPD8517 Approved
0.6379 Remote Similarity NPD8515 Approved
0.6379 Remote Similarity NPD8516 Approved
0.6353 Remote Similarity NPD2685 Clinical (unspecified phase)
0.6346 Remote Similarity NPD4225 Approved
0.6346 Remote Similarity NPD7638 Approved
0.6339 Remote Similarity NPD4632 Approved
0.6327 Remote Similarity NPD4251 Approved
0.6327 Remote Similarity NPD4250 Approved
0.6316 Remote Similarity NPD4752 Clinical (unspecified phase)
0.6316 Remote Similarity NPD7115 Discovery
0.6303 Remote Similarity NPD7507 Approved
0.63 Remote Similarity NPD5785 Approved
0.6296 Remote Similarity NPD6008 Approved
0.6289 Remote Similarity NPD6082 Clinical (unspecified phase)
0.6286 Remote Similarity NPD7639 Approved
0.6286 Remote Similarity NPD7640 Approved
0.6275 Remote Similarity NPD5282 Discontinued
0.6271 Remote Similarity NPD7642 Approved
0.6271 Remote Similarity NPD7829 Approved
0.6271 Remote Similarity NPD7830 Approved
0.625 Remote Similarity NPD5362 Discontinued
0.6239 Remote Similarity NPD5954 Clinical (unspecified phase)
0.6224 Remote Similarity NPD5786 Approved
0.6224 Remote Similarity NPD4249 Approved
0.6211 Remote Similarity NPD5369 Approved
0.62 Remote Similarity NPD5764 Clinical (unspecified phase)
0.62 Remote Similarity NPD6101 Approved
0.6163 Remote Similarity NPD7341 Phase 2
0.6154 Remote Similarity NPD7839 Suspended
0.6154 Remote Similarity NPD6319 Approved
0.6148 Remote Similarity NPD7319 Approved
0.6134 Remote Similarity NPD7604 Phase 2
0.6122 Remote Similarity NPD5363 Approved
0.6122 Remote Similarity NPD1694 Approved
0.6116 Remote Similarity NPD8074 Phase 3
0.6106 Remote Similarity NPD8297 Approved
0.6105 Remote Similarity NPD4822 Approved
0.6105 Remote Similarity NPD4821 Approved
0.6105 Remote Similarity NPD4819 Approved
0.6105 Remote Similarity NPD4820 Approved
0.6105 Remote Similarity NPD5790 Clinical (unspecified phase)
0.6092 Remote Similarity NPD7331 Phase 2
0.6091 Remote Similarity NPD6412 Phase 2
0.6083 Remote Similarity NPD7492 Approved
0.6078 Remote Similarity NPD8034 Phase 2
0.6078 Remote Similarity NPD6411 Approved
0.6078 Remote Similarity NPD8035 Phase 2
0.6064 Remote Similarity NPD5784 Clinical (unspecified phase)
0.6063 Remote Similarity NPD7966 Clinical (unspecified phase)
0.6036 Remote Similarity NPD6899 Approved
0.6036 Remote Similarity NPD6881 Approved
0.6034 Remote Similarity NPD6009 Approved
0.6033 Remote Similarity NPD8273 Phase 1
0.6033 Remote Similarity NPD6616 Approved
0.6019 Remote Similarity NPD6399 Phase 3
0.6017 Remote Similarity NPD6054 Approved
0.6 Remote Similarity NPD6675 Approved
0.6 Remote Similarity NPD5739 Approved
0.6 Remote Similarity NPD7128 Approved
0.6 Remote Similarity NPD6402 Approved
0.5984 Remote Similarity NPD7078 Approved
0.5983 Remote Similarity NPD7641 Discontinued
0.5979 Remote Similarity NPD4269 Approved
0.5979 Remote Similarity NPD5209 Approved
0.5979 Remote Similarity NPD4800 Clinical (unspecified phase)
0.5979 Remote Similarity NPD4270 Approved
0.5966 Remote Similarity NPD8268 Approved
0.5966 Remote Similarity NPD8267 Approved
0.5966 Remote Similarity NPD8266 Approved
0.5966 Remote Similarity NPD5983 Phase 2
0.5966 Remote Similarity NPD6921 Approved
0.5966 Remote Similarity NPD8269 Approved
0.5946 Remote Similarity NPD5697 Approved
0.5935 Remote Similarity NPD7736 Approved
0.5929 Remote Similarity NPD7290 Approved
0.5929 Remote Similarity NPD6883 Approved
0.5929 Remote Similarity NPD7102 Approved
0.5926 Remote Similarity NPD3728 Approved
0.5926 Remote Similarity NPD3730 Approved
0.592 Remote Similarity NPD7260 Phase 2
0.5918 Remote Similarity NPD6110 Phase 1
0.5917 Remote Similarity NPD6370 Approved
0.5914 Remote Similarity NPD8039 Approved
0.5902 Remote Similarity NPD6336 Discontinued
0.5902 Remote Similarity NPD8451 Approved
0.59 Remote Similarity NPD6422 Discontinued
0.5897 Remote Similarity NPD8137 Clinical (unspecified phase)
0.5895 Remote Similarity NPD4271 Approved
0.5895 Remote Similarity NPD4268 Approved
0.5893 Remote Similarity NPD7320 Approved
0.5893 Remote Similarity NPD6011 Approved
0.5882 Remote Similarity NPD6059 Approved
0.5877 Remote Similarity NPD6650 Approved
0.5877 Remote Similarity NPD8130 Phase 1
0.5877 Remote Similarity NPD6847 Approved
0.5877 Remote Similarity NPD6617 Approved
0.5877 Remote Similarity NPD6649 Approved
0.5877 Remote Similarity NPD6869 Approved
0.5873 Remote Similarity NPD6845 Suspended
0.5872 Remote Similarity NPD7632 Discontinued
0.5862 Remote Similarity NPD3197 Phase 1
0.5854 Remote Similarity NPD8448 Approved
0.5854 Remote Similarity NPD8293 Discontinued
0.5841 Remote Similarity NPD6372 Approved
0.5841 Remote Similarity NPD6013 Approved
0.5841 Remote Similarity NPD6012 Approved
0.5841 Remote Similarity NPD6373 Approved
0.5841 Remote Similarity NPD6014 Approved
0.5833 Remote Similarity NPD6015 Approved
0.5833 Remote Similarity NPD6016 Approved
0.5833 Remote Similarity NPD8444 Approved
0.5826 Remote Similarity NPD6882 Approved
0.581 Remote Similarity NPD7748 Approved
0.5804 Remote Similarity NPD5701 Approved
0.58 Remote Similarity NPD7520 Clinical (unspecified phase)
0.5794 Remote Similarity NPD6083 Phase 2
0.5794 Remote Similarity NPD6084 Phase 2
0.5794 Remote Similarity NPD7902 Approved
0.5785 Remote Similarity NPD5988 Approved
0.5785 Remote Similarity NPD8080 Discontinued
0.578 Remote Similarity NPD1700 Approved
0.5773 Remote Similarity NPD4252 Approved
0.5765 Remote Similarity NPD3198 Approved
0.5758 Remote Similarity NPD5332 Approved
0.5758 Remote Similarity NPD5331 Approved
0.5758 Remote Similarity NPD4788 Approved
0.5755 Remote Similarity NPD5695 Phase 3
0.5743 Remote Similarity NPD7521 Approved
0.5743 Remote Similarity NPD5330 Approved
0.5743 Remote Similarity NPD7334 Approved
0.5743 Remote Similarity NPD6409 Approved
0.5743 Remote Similarity NPD7146 Approved
0.5743 Remote Similarity NPD6684 Approved
0.5739 Remote Similarity NPD6401 Clinical (unspecified phase)
0.5738 Remote Similarity NPD8328 Phase 3
0.5732 Remote Similarity NPD3729 Clinical (unspecified phase)
0.5729 Remote Similarity NPD4238 Approved
0.5729 Remote Similarity NPD4802 Phase 2
0.5714 Remote Similarity NPD7328 Approved
0.5714 Remote Similarity NPD8392 Approved
0.5714 Remote Similarity NPD4790 Discontinued
0.5714 Remote Similarity NPD8391 Approved
0.5714 Remote Similarity NPD7327 Approved
0.5714 Remote Similarity NPD8390 Approved
0.5702 Remote Similarity NPD8274 Clinical (unspecified phase)
0.5702 Remote Similarity NPD8132 Clinical (unspecified phase)
0.5702 Remote Similarity NPD7503 Approved
0.5698 Remote Similarity NPD1145 Discontinued
0.5691 Remote Similarity NPD8299 Approved
0.5691 Remote Similarity NPD8342 Approved
0.5691 Remote Similarity NPD8341 Approved
0.5691 Remote Similarity NPD8340 Approved
0.5686 Remote Similarity NPD7524 Approved
0.5667 Remote Similarity NPD7516 Approved
0.5667 Remote Similarity NPD4247 Clinical (unspecified phase)
0.5652 Remote Similarity NPD4634 Approved
0.5631 Remote Similarity NPD5737 Approved
0.5631 Remote Similarity NPD7513 Clinical (unspecified phase)
0.5631 Remote Similarity NPD6903 Approved
0.5631 Remote Similarity NPD6672 Approved
0.563 Remote Similarity NPD8295 Clinical (unspecified phase)
0.563 Remote Similarity NPD7500 Approved
0.5625 Remote Similarity NPD4056 Clinical (unspecified phase)
0.5625 Remote Similarity NPD4057 Clinical (unspecified phase)
0.562 Remote Similarity NPD8294 Approved
0.562 Remote Similarity NPD8377 Approved
0.5619 Remote Similarity NPD5693 Phase 1
0.5619 Remote Similarity NPD6079 Approved
0.5619 Remote Similarity NPD7637 Suspended
0.5619 Remote Similarity NPD7515 Phase 2
0.5607 Remote Similarity NPD6356 Clinical (unspecified phase)
0.5603 Remote Similarity NPD2204 Approved

Structure

External Identifiers

PubChem CID   44568404
ChEMBL   CHEMBL519933
ZINC  

Physicochemical Properties

Molecular Weight:  424.25
ALogP:  0.3819
MLogP:  3.22
XLogP:  2.705
# Rotatable Bonds:  11
Polar Surface Area:  94.59
# H-Bond Aceptor:  7
# H-Bond Donor:  1
# Rings:  3
# Heavy Atoms:  30

Download Data

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General Info & Identifiers & Properties  
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Biological Activities  
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