Natural Product: NPC234767

Natural Product ID:  NPC234767
Common Name:   Hymenoic Acid
IUPAC Name:  
Synonyms:   Hymenoic acid
Molecular Formula:   C15H24O4
Standard InCHIKey:  LTNNRLSIPOPBOC-YKOULDITSA-N
Standard InCHI:  InChI=1S/C15H24O4/c1-10(4-3-5-11(2)14(16)17)12-6-8-13(9-7-12)15(18)19/h4,11-13H,3,5-9H2,1-2H3,(H,16,17)(H,18,19)/b10-4+/t11-,12-,13-/m0/s1
Canonical SMILES:  C[C@H](C(=O)O)CC/C=C(/[C@@H]1CC[C@H](CC1)C(=O)O)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO33121 hymenochaetaceae sp. Species Hymenochaetaceae Eukaryota PMID[18364258]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT3732 Individual Protein DNA polymerase lambda Homo sapiens IC50 < 100000 nM 24467317
NPT2 Others Unspecified IC50 > 200000 nM 24467317
NPT59 Individual Protein DNA polymerase beta Homo sapiens IC50 > 200000 nM PubChem BioAssay data set

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC234767 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.8529 High Similarity NPC35656
0.8382 Intermediate Similarity NPC160817
0.8333 Intermediate Similarity NPC472875
0.8286 Intermediate Similarity NPC192540
0.8286 Intermediate Similarity NPC279666
0.8286 Intermediate Similarity NPC476795
0.8194 Intermediate Similarity NPC321514
0.8194 Intermediate Similarity NPC110094
0.8194 Intermediate Similarity NPC280654
0.8194 Intermediate Similarity NPC260385
0.8182 Intermediate Similarity NPC322035
0.8182 Intermediate Similarity NPC100719
0.8182 Intermediate Similarity NPC166791
0.8169 Intermediate Similarity NPC180886
0.8169 Intermediate Similarity NPC69143
0.8169 Intermediate Similarity NPC309399
0.8143 Intermediate Similarity NPC103958
0.8143 Intermediate Similarity NPC251970
0.8143 Intermediate Similarity NPC3753
0.8143 Intermediate Similarity NPC241854
0.8143 Intermediate Similarity NPC183503
0.8143 Intermediate Similarity NPC283908
0.8143 Intermediate Similarity NPC237591
0.8143 Intermediate Similarity NPC301065
0.8143 Intermediate Similarity NPC161923
0.8143 Intermediate Similarity NPC476046
0.8125 Intermediate Similarity NPC174560
0.8125 Intermediate Similarity NPC125312
0.8082 Intermediate Similarity NPC199595
0.8082 Intermediate Similarity NPC327674
0.8056 Intermediate Similarity NPC471899
0.8056 Intermediate Similarity NPC471897
0.8056 Intermediate Similarity NPC61952
0.8056 Intermediate Similarity NPC107039
0.8028 Intermediate Similarity NPC476844
0.8028 Intermediate Similarity NPC472327
0.7973 Intermediate Similarity NPC37038
0.7973 Intermediate Similarity NPC104545
0.7945 Intermediate Similarity NPC179028
0.7945 Intermediate Similarity NPC74410
0.7945 Intermediate Similarity NPC198240
0.7941 Intermediate Similarity NPC290445
0.7941 Intermediate Similarity NPC36616
0.7917 Intermediate Similarity NPC89294
0.7867 Intermediate Similarity NPC221647
0.7867 Intermediate Similarity NPC327002
0.7867 Intermediate Similarity NPC278459
0.7838 Intermediate Similarity NPC274996
0.7838 Intermediate Similarity NPC231431
0.7838 Intermediate Similarity NPC477371
0.7838 Intermediate Similarity NPC16394
0.7838 Intermediate Similarity NPC196827
0.7838 Intermediate Similarity NPC158846
0.7833 Intermediate Similarity NPC281245
0.7826 Intermediate Similarity NPC67608
0.7808 Intermediate Similarity NPC165711
0.7808 Intermediate Similarity NPC97377
0.7778 Intermediate Similarity NPC201027
0.7763 Intermediate Similarity NPC133391
0.7733 Intermediate Similarity NPC477057
0.7714 Intermediate Similarity NPC235586
0.7705 Intermediate Similarity NPC36061
0.7705 Intermediate Similarity NPC294548
0.7705 Intermediate Similarity NPC139029
0.7705 Intermediate Similarity NPC1813
0.7703 Intermediate Similarity NPC59436
0.7703 Intermediate Similarity NPC239098
0.7703 Intermediate Similarity NPC169095
0.7681 Intermediate Similarity NPC476614
0.7681 Intermediate Similarity NPC53302
0.7671 Intermediate Similarity NPC469514
0.7662 Intermediate Similarity NPC200752
0.7662 Intermediate Similarity NPC167103
0.7662 Intermediate Similarity NPC97913
0.7662 Intermediate Similarity NPC477373
0.7656 Intermediate Similarity NPC329819
0.7647 Intermediate Similarity NPC142423
0.7647 Intermediate Similarity NPC308294
0.7639 Intermediate Similarity NPC472966
0.7639 Intermediate Similarity NPC55527
0.7639 Intermediate Similarity NPC213223
0.7632 Intermediate Similarity NPC90055
0.7632 Intermediate Similarity NPC162632
0.7632 Intermediate Similarity NPC477372
0.7632 Intermediate Similarity NPC147066
0.7632 Intermediate Similarity NPC473420
0.7632 Intermediate Similarity NPC40228
0.7632 Intermediate Similarity NPC229584
0.7632 Intermediate Similarity NPC38350
0.7632 Intermediate Similarity NPC142244
0.7632 Intermediate Similarity NPC471898
0.7632 Intermediate Similarity NPC274050
0.7632 Intermediate Similarity NPC201912
0.7632 Intermediate Similarity NPC263272
0.7632 Intermediate Similarity NPC14203
0.7632 Intermediate Similarity NPC267691
0.7612 Intermediate Similarity NPC53642
0.7612 Intermediate Similarity NPC470325
0.7606 Intermediate Similarity NPC288667
0.76 Intermediate Similarity NPC308545
0.76 Intermediate Similarity NPC82488
0.7581 Intermediate Similarity NPC88966
0.7581 Intermediate Similarity NPC87564
0.7581 Intermediate Similarity NPC154245
0.7581 Intermediate Similarity NPC281972
0.7581 Intermediate Similarity NPC6095
0.7581 Intermediate Similarity NPC261831
0.7581 Intermediate Similarity NPC85813
0.7581 Intermediate Similarity NPC290563
0.7581 Intermediate Similarity NPC25417
0.7581 Intermediate Similarity NPC424
0.7581 Intermediate Similarity NPC32467
0.7571 Intermediate Similarity NPC469914
0.7564 Intermediate Similarity NPC472864
0.7564 Intermediate Similarity NPC164577
0.7564 Intermediate Similarity NPC96095
0.7564 Intermediate Similarity NPC19849
0.7564 Intermediate Similarity NPC472865
0.7564 Intermediate Similarity NPC248758
0.7564 Intermediate Similarity NPC156981
0.7541 Intermediate Similarity NPC216407
0.7536 Intermediate Similarity NPC476626
0.7536 Intermediate Similarity NPC60120
0.7536 Intermediate Similarity NPC278895
0.7534 Intermediate Similarity NPC60718
0.7534 Intermediate Similarity NPC199445
0.7532 Intermediate Similarity NPC260956
0.7532 Intermediate Similarity NPC296367
0.7532 Intermediate Similarity NPC69101
0.7532 Intermediate Similarity NPC251779
0.75 Intermediate Similarity NPC271104
0.75 Intermediate Similarity NPC103634
0.75 Intermediate Similarity NPC244708
0.75 Intermediate Similarity NPC330659
0.75 Intermediate Similarity NPC36310
0.75 Intermediate Similarity NPC321017
0.75 Intermediate Similarity NPC161187
0.7468 Intermediate Similarity NPC269638
0.7468 Intermediate Similarity NPC142649
0.7467 Intermediate Similarity NPC121200
0.7465 Intermediate Similarity NPC67183
0.7465 Intermediate Similarity NPC91369
0.7436 Intermediate Similarity NPC310470
0.7436 Intermediate Similarity NPC70834
0.7436 Intermediate Similarity NPC49019
0.7436 Intermediate Similarity NPC83569
0.7436 Intermediate Similarity NPC69279
0.7436 Intermediate Similarity NPC215893
0.7436 Intermediate Similarity NPC105803
0.7432 Intermediate Similarity NPC899
0.7432 Intermediate Similarity NPC186554
0.7432 Intermediate Similarity NPC472305
0.7432 Intermediate Similarity NPC246445
0.7432 Intermediate Similarity NPC76966
0.7432 Intermediate Similarity NPC61863
0.7419 Intermediate Similarity NPC321062
0.7419 Intermediate Similarity NPC70387
0.7403 Intermediate Similarity NPC14044
0.7403 Intermediate Similarity NPC117960
0.7403 Intermediate Similarity NPC172309
0.7397 Intermediate Similarity NPC166797
0.7397 Intermediate Similarity NPC255168
0.7397 Intermediate Similarity NPC46610
0.7397 Intermediate Similarity NPC306928
0.7397 Intermediate Similarity NPC18819
0.7391 Intermediate Similarity NPC197089
0.7391 Intermediate Similarity NPC103734
0.7377 Intermediate Similarity NPC48162
0.7375 Intermediate Similarity NPC262085
0.7375 Intermediate Similarity NPC73038
0.7375 Intermediate Similarity NPC186975
0.7375 Intermediate Similarity NPC473226
0.7375 Intermediate Similarity NPC324063
0.7375 Intermediate Similarity NPC472869
0.7368 Intermediate Similarity NPC192329
0.7368 Intermediate Similarity NPC28319
0.7368 Intermediate Similarity NPC113363
0.7361 Intermediate Similarity NPC29328
0.7361 Intermediate Similarity NPC72343
0.7344 Intermediate Similarity NPC18951
0.7344 Intermediate Similarity NPC477201
0.7344 Intermediate Similarity NPC179764
0.7344 Intermediate Similarity NPC187777
0.7342 Intermediate Similarity NPC477289
0.7342 Intermediate Similarity NPC476038
0.7342 Intermediate Similarity NPC165064
0.7342 Intermediate Similarity NPC194937
0.7333 Intermediate Similarity NPC472014
0.7333 Intermediate Similarity NPC34110
0.7333 Intermediate Similarity NPC197659
0.7333 Intermediate Similarity NPC281296
0.7333 Intermediate Similarity NPC266193
0.7333 Intermediate Similarity NPC257666
0.7333 Intermediate Similarity NPC238227
0.7333 Intermediate Similarity NPC472300
0.7333 Intermediate Similarity NPC316324
0.7308 Intermediate Similarity NPC238991
0.7308 Intermediate Similarity NPC73882
0.7308 Intermediate Similarity NPC302661
0.7308 Intermediate Similarity NPC320514

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC234767 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7705 Intermediate Similarity NPD3172 Approved
0.7581 Intermediate Similarity NPD3196 Approved
0.7581 Intermediate Similarity NPD3194 Approved
0.7581 Intermediate Similarity NPD4266 Approved
0.7581 Intermediate Similarity NPD3195 Phase 2
0.7391 Intermediate Similarity NPD7331 Phase 2
0.7302 Intermediate Similarity NPD615 Clinical (unspecified phase)
0.7246 Intermediate Similarity NPD7341 Phase 2
0.7167 Intermediate Similarity NPD622 Approved
0.7119 Intermediate Similarity NPD634 Phase 3
0.7097 Intermediate Similarity NPD29 Approved
0.7097 Intermediate Similarity NPD28 Approved
0.7051 Intermediate Similarity NPD4695 Discontinued
0.7049 Intermediate Similarity NPD3173 Approved
0.6962 Remote Similarity NPD857 Phase 3
0.6941 Remote Similarity NPD5281 Approved
0.6941 Remote Similarity NPD5284 Approved
0.6941 Remote Similarity NPD7515 Phase 2
0.6905 Remote Similarity NPD7285 Clinical (unspecified phase)
0.6875 Remote Similarity NPD4223 Phase 3
0.6875 Remote Similarity NPD4752 Clinical (unspecified phase)
0.6875 Remote Similarity NPD3667 Approved
0.6875 Remote Similarity NPD4221 Approved
0.686 Remote Similarity NPD6399 Phase 3
0.6835 Remote Similarity NPD5368 Approved
0.6795 Remote Similarity NPD5784 Clinical (unspecified phase)
0.679 Remote Similarity NPD5362 Discontinued
0.679 Remote Similarity NPD7154 Phase 3
0.6782 Remote Similarity NPD7748 Approved
0.675 Remote Similarity NPD5369 Approved
0.6714 Remote Similarity NPD2664 Clinical (unspecified phase)
0.6707 Remote Similarity NPD4786 Approved
0.6707 Remote Similarity NPD3665 Phase 1
0.6707 Remote Similarity NPD3666 Approved
0.6707 Remote Similarity NPD3133 Approved
0.6707 Remote Similarity NPD4197 Approved
0.6706 Remote Similarity NPD5764 Clinical (unspecified phase)
0.6706 Remote Similarity NPD6101 Approved
0.6706 Remote Similarity NPD800 Approved
0.6705 Remote Similarity NPD5695 Phase 3
0.6667 Remote Similarity NPD4269 Approved
0.6667 Remote Similarity NPD342 Phase 1
0.6667 Remote Similarity NPD4270 Approved
0.6667 Remote Similarity NPD6435 Approved
0.6628 Remote Similarity NPD1090 Approved
0.6628 Remote Similarity NPD1089 Approved
0.6628 Remote Similarity NPD1086 Approved
0.6627 Remote Similarity NPD5329 Approved
0.6623 Remote Similarity NPD8039 Approved
0.662 Remote Similarity NPD3197 Phase 1
0.6588 Remote Similarity NPD6672 Approved
0.6588 Remote Similarity NPD5737 Approved
0.6582 Remote Similarity NPD3617 Approved
0.6557 Remote Similarity NPD3174 Discontinued
0.6557 Remote Similarity NPD4222 Approved
0.6556 Remote Similarity NPD6084 Phase 2
0.6556 Remote Similarity NPD7902 Approved
0.6556 Remote Similarity NPD6083 Phase 2
0.6552 Remote Similarity NPD6411 Approved
0.6548 Remote Similarity NPD4694 Approved
0.6548 Remote Similarity NPD6684 Approved
0.6548 Remote Similarity NPD4138 Approved
0.6548 Remote Similarity NPD4693 Phase 3
0.6548 Remote Similarity NPD4519 Discontinued
0.6548 Remote Similarity NPD7521 Approved
0.6548 Remote Similarity NPD3618 Phase 1
0.6548 Remote Similarity NPD5690 Phase 2
0.6548 Remote Similarity NPD6409 Approved
0.6548 Remote Similarity NPD6422 Discontinued
0.6548 Remote Similarity NPD5280 Approved
0.6548 Remote Similarity NPD4689 Approved
0.6548 Remote Similarity NPD6098 Approved
0.6548 Remote Similarity NPD7334 Approved
0.6548 Remote Similarity NPD4688 Approved
0.6548 Remote Similarity NPD5205 Approved
0.6548 Remote Similarity NPD4623 Approved
0.6548 Remote Similarity NPD4690 Approved
0.6548 Remote Similarity NPD5330 Approved
0.6548 Remote Similarity NPD3574 Clinical (unspecified phase)
0.6548 Remote Similarity NPD7146 Approved
0.6543 Remote Similarity NPD226 Approved
0.6512 Remote Similarity NPD6673 Approved
0.6512 Remote Similarity NPD5347 Phase 2
0.6512 Remote Similarity NPD6080 Approved
0.6512 Remote Similarity NPD4753 Phase 2
0.6512 Remote Similarity NPD5346 Phase 2
0.6512 Remote Similarity NPD6904 Approved
0.6506 Remote Similarity NPD3668 Phase 3
0.6484 Remote Similarity NPD5696 Approved
0.6477 Remote Similarity NPD5778 Approved
0.6477 Remote Similarity NPD5779 Approved
0.6477 Remote Similarity NPD1088 Approved
0.6471 Remote Similarity NPD3573 Approved
0.6462 Remote Similarity NPD3186 Phase 1
0.6456 Remote Similarity NPD4756 Discovery
0.6444 Remote Similarity NPD7614 Phase 1
0.6437 Remote Similarity NPD46 Approved
0.6437 Remote Similarity NPD5692 Phase 3
0.6437 Remote Similarity NPD6698 Approved
0.6429 Remote Similarity NPD1694 Approved
0.6429 Remote Similarity NPD5363 Approved
0.6429 Remote Similarity NPD7520 Clinical (unspecified phase)
0.642 Remote Similarity NPD4252 Approved
0.642 Remote Similarity NPD4821 Approved
0.642 Remote Similarity NPD4819 Approved
0.642 Remote Similarity NPD4820 Approved
0.642 Remote Similarity NPD4822 Approved
0.6404 Remote Similarity NPD5122 Clinical (unspecified phase)
0.6395 Remote Similarity NPD6903 Approved
0.6395 Remote Similarity NPD5208 Approved
0.6395 Remote Similarity NPD7513 Clinical (unspecified phase)
0.6386 Remote Similarity NPD5331 Approved
0.6386 Remote Similarity NPD5332 Approved
0.6375 Remote Similarity NPD4271 Approved
0.6375 Remote Similarity NPD4268 Approved
0.6375 Remote Similarity NPD3732 Approved
0.6364 Remote Similarity NPD5694 Approved
0.6364 Remote Similarity NPD6050 Approved
0.6364 Remote Similarity NPD5693 Phase 1
0.6353 Remote Similarity NPD5786 Approved
0.6353 Remote Similarity NPD5279 Phase 3
0.6341 Remote Similarity NPD4692 Approved
0.6341 Remote Similarity NPD4790 Discontinued
0.6341 Remote Similarity NPD4139 Approved
0.6333 Remote Similarity NPD1693 Approved
0.6322 Remote Similarity NPD5328 Approved
0.629 Remote Similarity NPD39 Approved
0.6279 Remote Similarity NPD1087 Approved
0.6279 Remote Similarity NPD4793 Discontinued
0.625 Remote Similarity NPD5207 Approved
0.6237 Remote Similarity NPD6404 Discontinued
0.6222 Remote Similarity NPD7900 Approved
0.6222 Remote Similarity NPD7901 Clinical (unspecified phase)
0.622 Remote Similarity NPD5790 Clinical (unspecified phase)
0.6216 Remote Similarity NPD4224 Phase 2
0.619 Remote Similarity NPD9491 Approved
0.6184 Remote Similarity NPD4137 Phase 3
0.618 Remote Similarity NPD8035 Phase 2
0.618 Remote Similarity NPD7983 Approved
0.618 Remote Similarity NPD8034 Phase 2
0.618 Remote Similarity NPD6079 Approved
0.6173 Remote Similarity NPD227 Approved
0.6173 Remote Similarity NPD225 Approved
0.6154 Remote Similarity NPD6356 Clinical (unspecified phase)
0.6154 Remote Similarity NPD4629 Approved
0.6154 Remote Similarity NPD5210 Approved
0.6154 Remote Similarity NPD1698 Clinical (unspecified phase)
0.6129 Remote Similarity NPD7638 Approved
0.6111 Remote Similarity NPD4194 Approved
0.6111 Remote Similarity NPD4192 Approved
0.6111 Remote Similarity NPD4193 Approved
0.6111 Remote Similarity NPD4202 Approved
0.6111 Remote Similarity NPD368 Approved
0.6111 Remote Similarity NPD4191 Approved
0.6104 Remote Similarity NPD4747 Approved
0.6104 Remote Similarity NPD4691 Approved
0.6102 Remote Similarity NPD633 Phase 3
0.6102 Remote Similarity NPD9448 Phase 2
0.6102 Remote Similarity NPD77 Approved
0.6102 Remote Similarity NPD9450 Approved
0.6102 Remote Similarity NPD9655 Approved
0.6098 Remote Similarity NPD4195 Approved
0.6087 Remote Similarity NPD5222 Approved
0.6087 Remote Similarity NPD7839 Suspended
0.6087 Remote Similarity NPD5220 Clinical (unspecified phase)
0.6087 Remote Similarity NPD4697 Phase 3
0.6087 Remote Similarity NPD5221 Approved
0.6082 Remote Similarity NPD6402 Approved
0.6082 Remote Similarity NPD7128 Approved
0.6082 Remote Similarity NPD5739 Approved
0.6082 Remote Similarity NPD6675 Approved
0.6067 Remote Similarity NPD4096 Approved
0.6067 Remote Similarity NPD5785 Approved
0.6066 Remote Similarity NPD387 Clinical (unspecified phase)
0.6064 Remote Similarity NPD2066 Phase 3
0.6064 Remote Similarity NPD7639 Approved
0.6064 Remote Similarity NPD7640 Approved
0.6053 Remote Similarity NPD3621 Clinical (unspecified phase)
0.6047 Remote Similarity NPD6082 Clinical (unspecified phase)
0.6044 Remote Similarity NPD6001 Approved
0.6029 Remote Similarity NPD3729 Clinical (unspecified phase)
0.6026 Remote Similarity NPD6081 Approved
0.6026 Remote Similarity NPD4243 Approved
0.6023 Remote Similarity NPD4518 Approved
0.6022 Remote Similarity NPD1565 Approved
0.6022 Remote Similarity NPD5173 Approved
0.6022 Remote Similarity NPD4755 Approved
0.6022 Remote Similarity NPD1566 Phase 3
0.6022 Remote Similarity NPD1564 Approved
0.602 Remote Similarity NPD5697 Approved
0.602 Remote Similarity NPD5701 Approved
0.6 Remote Similarity NPD9439 Approved
0.6 Remote Similarity NPD4810 Clinical (unspecified phase)
0.6 Remote Similarity NPD1239 Approved
0.6 Remote Similarity NPD4788 Approved
0.6 Remote Similarity NPD3704 Approved
0.6 Remote Similarity NPD9438 Approved
0.5978 Remote Similarity NPD5654 Approved
0.5972 Remote Similarity NPD4246 Clinical (unspecified phase)
0.5968 Remote Similarity NPD5326 Phase 3

Structure

External Identifiers

PubChem CID  
ChEMBL   CHEMBL494213
ZINC  

Physicochemical Properties

Molecular Weight:  268.17
ALogP:  1.8122
MLogP:  2.67
XLogP:  3.147
# Rotatable Bonds:  10
Polar Surface Area:  74.6
# H-Bond Aceptor:  4
# H-Bond Donor:  2
# Rings:  1
# Heavy Atoms:  19

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs