Component: Pueraria lobata 葛花


Description of the Component

Component ID
TCMH679
Latin Name
Pueraria lobata
English Name
flower bud of lobed kudzuvine
Chinese Pinyin Name
Ge Hua
中文名
葛花
TCM Properties
Cool,Pungent,Sweet
TCM Meridians
Spleen,Stomach
Therapeutic Class English
For relieving exterior syndrome
Therapeutic Class Chinese
解表
Functions
relieve fever, promote the production of body fluid,facilitate eruption, and arrest diarrhea
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAJ4206-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3418 Die Da Wan Hua You 跌打万花油
TCMFx1399 Ge Flower Waking-Up Decoction 葛花解酲汤
TCMFx2499 Ge Flower Waking-Up Decoction 葛花解酲汤
TCMF4969 Jin Ju Wu Hua Cha Infusion 金菊五花茶冲剂
TCMFx5694 Shang Ke Wan Hua You 伤科万花油
TCMFx5402 Wu Hua Cha Granules 五花茶颗粒

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT214 MGLL Monoglyceride lipase Unclassified Q99685
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT341 NR1I2 Pregnane X receptor Nuclear receptor O75469
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1092 Fatty acid synthase
TCMT1099 Neuraminidase
TCMT1136 Neuraminidase
TCMT1227 Streptococcus
TCMT1246 Escherichia coli
TCMT1284 Penicillium expansum
TCMT1438 Plasmodium falciparum

Ingredient Structrues

Ingredient ID: TCMC984
Formula: C21H20O9

Ingredient ID: TCMC983
Formula: C15H10O4

Ingredient ID: TCMC950
Formula: C15H8O5

Ingredient ID: TCMC655
Formula: C4H6N4O3

Ingredient ID: TCMC549
Formula: C21H20O10

Ingredient ID: TCMC2050
Formula: C11H10O4

Ingredient ID: TCMC1965
Formula: C21H20O9

Ingredient ID: TCMC1792
Formula: C22H22O9

Ingredient ID: TCMC1236
Formula: C15H10O5

Ingredient ID: TCMC1186
Formula: C16H12O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC549 C21H20O10 5-Hydroxy-3-(4-Hydroxyphenyl)-7-[3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxychromen-4-One 432.11 -3.7945 2.67 0.404 6 6 166.14 10 4 31 1
TCMC655 C4H6N4O3 Allantoin 158.04 -0.2279 1.13 -0.469 7 5 121.29 5 1 11 0
TCMC950 C15H8O5 Coumestrol 268.04 -1.1658 2.56 1.952 1 2 79.9 2 4 20 0
TCMC983 C15H10O4 Daidzein 254.06 -1.5873 2.67 2.475 1 2 66.76 3 3 19 0
TCMC984 C21H20O9 Daidzin 416.11 -3.3342 2.78 1.367 6 5 145.91 9 4 30 0
TCMC1186 C16H12O4 Formononetin 268.07 -1.1788 2.78 2.994 1 1 55.76 4 3 20 0
TCMC1236 C15H10O5 Genistein 270.05 -2.0476 2.56 1.512 1 3 86.99 4 3 20 0
TCMC1792 C22H22O9 Ononin 430.13 -2.9257 2.89 1.886 6 4 134.91 10 4 31 0
TCMC1965 C21H20O9 Puerarin 416.11 -3.823 2.78 0.4 6 6 156.91 9 4 30 1
TCMC2050 C11H10O4 Scoparone 206.06 0.1664 2.23 1.607 1 0 44.76 4 2 15 0

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