Component: Trigonella foenum-graecum 盐胡芦巴


Description of the Component

Component ID
TCMH2375
Latin Name
Trigonella foenum-graecum
English Name
Fenugreek
Chinese Pinyin Name
Yan Hu Lu Ba
中文名
盐胡芦巴
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
CFDA
Barcode ID
PSUPP015-15
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF989 Pei Kun Pills 培坤丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT191 STAT3 Signal transducer and activator of transcription 3 Transcription factor P40763
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1092 Fatty acid synthase
TCMT1099 Neuraminidase
TCMT1136 Neuraminidase
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1284 Penicillium expansum
TCMT1438 Plasmodium falciparum
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC983
Formula: C15H10O4

Ingredient ID: TCMC855
Formula: C16H12O5

Ingredient ID: TCMC811
Formula: C16H12O5

Ingredient ID: TCMC791
Formula: C40H56

Ingredient ID: TCMC721
Formula: C6H14N4O2

Ingredient ID: TCMC601
Formula: C16H10O6

Ingredient ID: TCMC529
Formula: C21H20O10

Ingredient ID: TCMC525
Formula: C15H12O5

Ingredient ID: TCMC2233
Formula: C21H20O10

Ingredient ID: TCMC2190
Formula: C7H7NO2

Ingredient ID: TCMC2188
Formula: C17H14O7

Ingredient ID: TCMC2158
Formula: C12H17N4OS

Ingredient ID: TCMC2051
Formula: C10H8O4

Ingredient ID: TCMC1734
Formula: C15H12O5

Ingredient ID: TCMC1403
Formula: C21H20O11

Ingredient ID: TCMC1331
Formula: C6H9N3O2

Ingredient ID: TCMC1202
Formula: C7H6O5

Ingredient ID: TCMC1186
Formula: C16H12O4

Ingredient ID: TCMC1072
Formula: C27H42O3

Ingredient ID: TCMC1063
Formula: C45H72O16

Ingredient ID: TCMC1024
Formula: C6H9N3O2

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC525 C15H12O5 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-2,3-Dihydrochromen-4-One 272.07 -1.8144 2.56 0.897 1 3 86.99 4 3 20 0
TCMC529 C21H20O10 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-6-[3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Chromen-4-One 432.11 -4.1202 2.67 -0.508 6 7 177.14 10 4 31 1
TCMC601 C16H10O6 9-Hydroxy-7-(4-Hydroxyphenyl)-[1,3]Dioxolo[4,5-G]Chromen-8-One 298.05 -1.89 2.56 1.514 1 2 85.22 3 4 22 0
TCMC721 C6H14N4O2 Arginine 174.11 -2.1807 1.46 -2.924 6 5 125.22 9 0 12 0
TCMC791 C40H56 Beta Carotene 536.44 8.935 5.86 14.734 0 0 0 20 2 40 1
TCMC811 C16H12O5 Biochanin 284.07 -1.6391 2.67 2.031 1 2 75.99 5 3 21 0
TCMC855 C16H12O5 Calycosin 284.07 -1.6391 2.67 2.031 1 2 75.99 5 3 21 0
TCMC983 C15H10O4 Daidzein 254.06 -1.5873 2.67 2.475 1 2 66.76 3 3 19 0
TCMC1024 C6H9N3O2 D-Histidine 155.07 -1.3116 1.57 -3.134 5 3 92 5 1 11 0
TCMC1063 C45H72O16 Dioscin 868.48 -3.9636 4.65 2.836 16 8 235.68 21 9 61 2
TCMC1072 C27H42O3 Disogenin 414.31 0.2771 4.1 6.041 3 1 38.69 5 6 30 1
TCMC1186 C16H12O4 Formononetin 268.07 -1.1788 2.78 2.994 1 1 55.76 4 3 20 0
TCMC1202 C7H6O5 Gallic Acid 170.02 -1.6207 1.68 0.002 2 4 97.99 5 1 12 0
TCMC1331 C6H9N3O2 Histidine 155.07 -1.3116 1.57 -3.134 5 3 92 5 1 11 0
TCMC1403 C21H20O11 Isoorientin 448.1 -4.5805 2.56 -1.042 6 8 197.37 11 4 32 1
TCMC1734 C15H12O5 Naringenin 272.07 -1.8144 2.56 0.897 1 3 86.99 4 3 20 0
TCMC2051 C10H8O4 Scopoletin 192.04 -0.2421 2.12 1.088 1 1 55.76 3 2 14 0
TCMC2158 C12H17N4OS Thiamine 265.11 -2.3748 2.12 0.641 4 3 100.59 7 2 18 0
TCMC2188 C17H14O7 Tricin 330.07 -1.9881 2.56 0.679 1 3 105.45 8 3 24 0
TCMC2190 C7H7NO2 Trigonelline 137.05 -2.2592 1.9 0.283 2 0 44.01 3 1 10 0
TCMC2233 C21H20O10 Vitexin 432.11 -4.1202 2.67 -0.508 6 7 177.14 10 4 31 1

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1. General Information of the Component  
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3. Putative Targets  
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5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)