Component: Amaranthus spinosus 刺苋


Description of the Component

Component ID
TCMH325
Latin Name
Amaranthus spinosus
English Name
spiny amaranth
Chinese Pinyin Name
Ci Wan
中文名
刺苋
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
MHPAD801-09
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx5694 Shang Ke Wan Hua You 伤科万花油

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1092 Fatty acid synthase
TCMT1099 Neuraminidase
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1438 Plasmodium falciparum
TCMT1458 Filobasidiella neoformans

Ingredient Structrues

Ingredient ID: TCMC981
Formula: C11H14N2O

Ingredient ID: TCMC676
Formula: C20H16O5

Ingredient ID: TCMC585
Formula: C16H12O5

Ingredient ID: TCMC2612
Formula: C20H18O5

Ingredient ID: TCMC2206
Formula: C20H18O6

Ingredient ID: TCMC2162
Formula: CH4N2S

Ingredient ID: TCMC1236
Formula: C15H10O5

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC585 C16H12O5 7-Hydroxy-3-(4-Hydroxyphenyl)-5-Methoxychromen-4-One 284.07 -1.6391 2.67 2.031 1 2 75.99 5 3 21 0
TCMC676 C20H16O5 Alpinumisoflavone 336.1 -0.6795 3.11 2.912 1 2 75.99 5 4 25 0
TCMC981 C11H14N2O Cytisine 190.11 -1.1881 2.34 -0.251 3 1 32.34 0 3 14 0
TCMC1236 C15H10O5 Genistein 270.05 -2.0476 2.56 1.512 1 3 86.99 4 3 20 0
TCMC2162 CH4N2S Thiourea 76.01 0.5528 1.24 0.067 2 2 88.67 2 0 4 0
TCMC2206 C20H18O6 Uncinanone A 354.11 -0.6305 3 2.019 1 4 107.22 9 3 26 0
TCMC2612 C20H18O5 Wighteone 338.12 -0.1702 3.11 2.982 1 3 86.99 8 3 25 0

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1. General Information of the Component  
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3. Putative Targets  
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5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)