TCM Prescription: Bu Shen Yi Nao Pills



Prescription Description
Prescription IDTCMF613
Pinyin NameBu Shen Yi Nao Wan 
Chinese Name补肾益脑丸
English NameBu Shen Yi Nao Pills
Function Description气血两亏, 阳虚气弱, 心跳气短, 失眠健忘, 遗精盗汗, 腰腿酸软, 耳聋耳鸣
IndicationsInvoluntary ejaculation disorder, Tinnitus disorder, Forgetfulness disorder, Insomnia
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ];
Human Tissues Associated with IndicationBrain, Blood, Heart
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1349 Cervus elaphus 鹿茸 TCMH1349 ABMC060-05
TCMH877 Radix ginseng rubra 红参 TCMH877 GBVE1679-11
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2682 Cinnabaris 朱砂 TCMH2682
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6881
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8006
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, MET, PPARA, PPARG, TRPV1 10.4838
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, KDR, MET, PPARA, PPARG, SLC1A1, SRC, TRPV1, XDH 9.70987
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, HMGCR, PIM1, PPARA, PPARG, XDH 8.84954
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 8.11495
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1, TRPV1 7.87889
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, HMGCR, HSD11B1, HSD17B1 7.28997
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.86175
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PPARG 6.50338
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1, TRPV1 6.49858
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.48675
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 6.48411
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PTPN1, SRC, TRPV1, XDH 6.37451
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.37451
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.37386
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, NR3C1, PPARA, PPARG, SRC, TRPV1 6.33455
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, GRIK5, GRM5, HMGCR, HSP90AB1, IGF1R, MMP2, MMP9, NR3C1, PPARA, PPARG, SRC, TRPV1 6.22807
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.09733
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.00051
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.87854
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SLC1A1, SRC, TRPV1, XDH 5.8462
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARG, PTPN1, SRC, TRPV1, XDH 5.82177
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.82177
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 5.61552
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 5.52575
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD17B1, PPARG, XDH 5.51438
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.45342
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.28131
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 5.25547
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.21702
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, SRC, TRPV1 5.20063
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, MET, PPARG, SRC, TRPV1 5.15952
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.74791
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1, TRPV1 4.74791
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.71033
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.71033
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.71033
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.63095
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 4.63095
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, SRC, TRPV1 4.61048
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.57037
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, NR3C1, PPARG, SRC, TRPV1 4.51007
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.49665
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1 4.46531
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.46026
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1 4.37644
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, PPARG, SRC, TRPV1 4.32298
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PTPN1, SRC, XDH 4.28317
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, SLC1A1, TRPV1 4.25217
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 4.25217
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.23393
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PTPN1, SRC, XDH 4.18998
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, SRC, TRPV1 4.18917
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.18845
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, NR3C1, PPARA, PPARG, SRC, TRPV1 4.07788
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PPARG, SRC, XDH 4.04679
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, HMGCR, HSP90AB1, KDR, MET, MMP9, PTPN1, SRC, XDH 4.00057
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PPARG, SRC 3.98154
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, HMGCR, HSP90AB1, KDR, MET, MMP9, PTPN1, SRC, XDH 3.98013
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TRPV1 3.97555
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 3.97373
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 3.96714
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 3.92142
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 3.82107
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.81522
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.78871
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 3.73445
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 3.73445
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, CHRM5, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.69352
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, PTPN1, SRC, TRPV1 3.68923
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, SRC, TRPV1 3.68923
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.67968
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.67968
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.67892
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, CHRM5, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.66537
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, HMGCR, HSP90AB1, KDR, NR3C1, PPARG, SRC, TRPV1 3.64549
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.60781
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.60781
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.59246
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PPARG, SRC, TRPV1 3.54686
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC 3.51092
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.4944
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.42988
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 3.42858
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, HSP90AA1, MMP1, MMP2, MMP9, SRC, XDH 3.40321
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, NR3C1, PIM1, PPARA, PPARG, SRC 3.39767
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, HSP90AB1 3.35538
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD17B1 3.33864
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, PIM1, PPARA, PPARG, PTPN1, SRC, XDH 3.31037
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, SRC, TRPV1 3.29569
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, PPARG, TRPV1 3.261
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.25971
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.21835
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.21835
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.20908
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.18844
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.1714
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.1714
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 3.1714
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD17B1 3.15423
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.13593
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, HSP90AB1, KDR, NR3C1, SRC, TRPV1 3.09589
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, PPARG, SRC 3.08982
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SRC, TRPV1, XDH 3.08636
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, GRM1, GRM5, GRM8, HMGCR, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TRPV1 3.0789
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, NR3C1, PPARG, SRC 3.0789
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, GRM1, HMGCR, HSP90AA1, HSP90AB1, MMP2, PPARA, PPARG, SRC, TRPV1 3.01023
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.97568
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SRC, TRPV1, XDH 2.97356
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, PPARG, PTPN1, SRC 2.96472
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.9538
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, MMP9, PPARA, PPARG, SLC1A1, SRC, TRPV1, XDH 2.94614
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1 2.92312
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSP90AB1, KDR, PPARA, PPARG, SRC 2.87
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CHRM1, CYP19A1, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, MMP9, PPARA, PPARG, PTPN1, SRC, TRPV1 2.84351
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.84351
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.84351
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.84351
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SLC1A1, SRC, TRPV1, XDH 2.83499
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR 2.82884
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.77679
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC 2.77343
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 2.65012
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR 2.61964
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 2.61964
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 2.61964
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.61035
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.61035
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, NR3C1, PPARA, PPARG, SRC 2.55842
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, PTPN1, SRC, TRPV1 2.55362
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, PTPN1, SRC, XDH 2.53308
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, IGF1R, PPARA, PPARG, SRC, TRPV1 2.52919
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG, SRC 2.51393
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, GRIK5, HSP90AA1, HSP90AB1, SLC1A1, TRPV1 2.51039
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 2.49523
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, CDC25B, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 2.48626
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CYP19A1, ESR1, FABP4, HMGCR, HSP90AA1, HSP90AB1, IGF1R, MET, MMP2, PPARA, PPARG, PTPN1, SRC, XDH 2.48624
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.47468
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.45861
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.44716
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, NR3C1, PPARG, SRC 2.44716
[BP] GO:0099566 None GRM1, GRM5 2.44716
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.44716
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG 2.44716
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.43828
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, HMGCR, KDR, SRC, TRPV1 2.43692
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 2.39263
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.37553
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, HMGCR, HSP90AB1, KDR, MET, MMP9, PTPN1, SRC, XDH 2.3466
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSP90AB1, KDR, MET, MMP2, MMP9, PIM1, PPARA, PPARG, SRC 2.3325
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, SRC 2.31669
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, HSP90AA1, HSP90AB1, MMP9, SLC1A1, TRPV1, XDH 2.30033
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.27924
[BP] GO:0010243 response to organonitrogen compound AKR1B1, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TRPV1 2.26971
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, CDC25B, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 2.26653
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.26525
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 2.24683
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.24683
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 2.22781
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, SRC 2.22163
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SLC1A1, SRC, TRPV1, XDH 2.21731
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.21658
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, SRC 2.214
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, ESR1, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, MMP9, PPARG, PTPN1, SRC, XDH 2.214
[BP] GO:0042391 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 2.21171
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.21171
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.21171
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21171
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.20719
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, GRM1, HCAR2, SLC1A1, TRPV1 2.20264
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, HMGCR, HSP90AA1, KDR, SRC 2.20212
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, GRM1, HCAR2, HMGCR, HSP90AB1, KDR, MET, MMP9, PIM1, PPARG, SLC1A1, SRC, TRPV1, XDH 2.19262
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.19262
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.19262
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.19262
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.19262
[BP] GO:0043393 regulation of protein binding AURKB, HSP90AB1, MET, MMP9, PPARA, SRC 2.19029
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, PTPN1, SRC 2.17714
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PPARG 2.16923
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.16373
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG 2.12156
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.10584
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.10401
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.10401
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, CDC25B, CSNK2A1, ESR1, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, KDR, MMP9, PPARG, PTPN1, SRC, XDH 2.08
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.08
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GRM1, HMGCR, HSP90AA1, HSP90AB1, KDR, MET, MMP2, MMP9, PTPN1, SRC, XDH 2.07859
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG 2.06813
[BP] GO:1901698 response to nitrogen compound AKR1B1, FABP3, FLT3, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TRPV1 2.05732
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.05732
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, SRC 2.05732
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARG, SRC 2.05654
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, ESR1, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARG, SRC, TRPV1 2.05654
[BP] GO:0046541 None CHRM1, CHRM3 2.05654
[BP] GO:0032800 receptor biosynthetic process ACHE, PPARG 2.05654
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.05654
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.05654
[BP] GO:0010891 None PPARA, PPARG 2.05654
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, PTPN1, SRC 2.05328
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, FABP3, HSP90AA1, PPARA, PPARG, SLC1A1, TRPV1 2.05328
[BP] GO:0046320 None FABP3, PPARA, PPARG 2.04412
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.04412
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR 2.00687
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FABP3, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SRC, TRPV1, XDH 2.00209
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, MET, SLC1A1, SRC, TRPV1 7.9811
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 6.66754
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 5.33462
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TRPV1 4.89474
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 4.81091
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, SLC1A1, SRC, TRPV1 4.61048
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC, TRPV1 4.20552
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 4.07788
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PTPN1, SLC1A1, SRC, TRPV1 3.73765
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1, TRPV1 3.73445
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.40321
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, SRC, TRPV1 3.37941
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, SRC, TRPV1 3.37941
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 3.11255
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, SRC 3.11255
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.72132
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, HSP90AB1 2.36027
[CC] GO:0031253 None ADORA1, CA4, CA9, HSP90AA1, HSP90AB1, SRC, TRPV1 2.06814
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.0943
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, XDH 15.6775
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.8006
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.6265
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 8.47225
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.26698
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.17562
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SLC1A1, SRC, TRPV1, XDH 8.14533
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.9811
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 7.57021
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 7.29646
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSP90AA1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, XDH 7.2552
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.89337
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.89337
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, PPARG, TRPV1 6.79894
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, PPARA, PPARG, PTPN1 6.79497
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.37451
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARG, TRPV1 6.37386
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARG, TRPV1 6.37386
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.36898
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PPARA, PPARG, SRC, TRPV1 6.15664
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD17B1, XDH 5.87854
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.38006
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SLC1A1, TRPV1, XDH 5.35154
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.2713
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC 5.05114
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 4.88809
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, SLC1A1, TRPV1, XDH 4.53998
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.50873
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.04679
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD17B1, SRC, XDH 3.79396
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 3.68293
[MF] GO:0030235 nitric-oxide synthase regulator activity ESR1, HSP90AA1, HSP90AB1 3.60781
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, NR3C1, PPARA, PPARG 3.4944
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.40321
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 3.31654
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, FABP3, FABP4, HSD17B1, NR3C1, PPARA, PPARG, TRPV1 3.30371
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.29569
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.28785
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1, XDH 2.99056
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.97568
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.94171
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NR3C1 2.84351
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.84351
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.84351
[MF] GO:0008389 None CYP2A13, CYP2A6 2.84351
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, HSD17B1, NR3C1 2.83724
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.58719
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, PPARG 2.55803
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, PPARG 2.55803
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.49326
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, KDR, NR3C1 2.47468
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.44716
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.44716
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.44716
[MF] GO:0099583 None GRM1, GRM5 2.44716
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.43654
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.43654
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG 2.39854
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.35841
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1 2.26653
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21171
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.21171
[MF] GO:0004971 None GRIA2, GRIA4 2.21171
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.21171
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.19262
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.17714
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.16373
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.10401
[MF] GO:0042802 identical protein binding ACHE, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, TRPV1, XDH 2.06813
[MF] GO:0005504 None FABP3, FABP4, PPARG 2.06813
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.06813
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.06813
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.05654
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.05654
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.00927


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.6602
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GRIK5, CHRM5, TRPV1, NR3C1, GRM1, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 11.971
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, MMP9, ESR1, GRM1, ESR2 7.3462
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.4083
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.9927
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.9927
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.5874
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.7018
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, HSP90AB1, FLT3, MMP1, MMP2, PPARG, MMP9, MET, IGF1R 4.2022
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, ADORA1, PPARA, GRIA4 4.2842
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.2842
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, HMGCR, CYP3A4, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, XDH 4.0331
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2842
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.348
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.5933
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, CHRM1, CHRM5, GRM1 3.6258
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0364
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, CHRM1, KDR, MET, IGF1R 3.0547
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.3402
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, CDC25B, IGF1R 2.7319
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.7183
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.7303
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.4399
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.2269
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7319
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3027
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.9465
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.2766
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.2269
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1582
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, CYP3A4 2.185
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.8254
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.838
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, IGF1R 1.9442
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7796
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.6091
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.1627
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.0959
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.9465
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5207
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12 1.7293
AMPK signaling pathway_Homo sapiens_hsa04152 PPARG, HMGCR, IGF1R 1.6364
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0972
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9686
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0639
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1126
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PPARG, IGF1R 1.0972
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0972
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.1786
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.011
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4069
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.249
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.3069
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2751
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3069
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3676
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4069
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9686
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8514
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.9129
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9686
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9618
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.9014
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8742
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0972
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2212
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.6799
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1 0.7688
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7721
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3025
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 1.2244
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2386
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3868
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2996
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2984
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.4069
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3287
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3199
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3286
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3603
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3199
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3683
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3891
Platelet activation_Homo sapiens_hsa04611 SRC 0.406
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3603
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.3853
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3853
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3853
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3931
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3931
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.406
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.433
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.406
Axon guidance_Homo sapiens_hsa04360 MET 0.4015
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.412
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4528
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.482
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4559
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.482
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.482
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.482
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.5063
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.482
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4744
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.482
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.482
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.482
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4781
Peroxisome_Homo sapiens_hsa04146 XDH 0.482
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.482
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5376
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5571
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5558
Glioma_Homo sapiens_hsa05214 IGF1R 0.5571
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5571
Shigellosis_Homo sapiens_hsa05131 SRC 0.5571
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6488
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8324
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6334
Malaria_Homo sapiens_hsa05144 MET 0.6444
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.656
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7983
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7282
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0032
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2868
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.8271
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8049
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.856
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8514
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9087


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)