TCM Prescription: Si Shi Gan He Tea



Prescription Description
Prescription IDTCMF5947
Pinyin NameSi Shi Gan He Cha
Chinese Name四时甘和茶
English NameSi Shi Gan He Tea
Function Description感冒, 中暑, 积滞
IndicationsCommon cold disorder, Common cold, Dyspepsia, Sunstroke
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
MD92 [Dyspepsia, 消化不良 ];
NF01.0 [Heat stroke, 中暑 ];
Human Tissues Associated with IndicationLung, Blood, Spleen, Intestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH436 Fructus oryzae germinatus 稻芽 TCMH436
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH226 Camellia sinensis 茶叶 TCMH226 ITSAG2924-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ABCB1, ABCG2, ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, KIT, MMP2, MMP9, PPARA, RORC, SRC, TERT, TOP1, TYR 10.0568
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.69569
[BP] GO:0010033 response to organic substance ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, KIT, MMP2, PPARA, RORC, SRC, TYR 8.36252
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 8.21612
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, KIT, MET, PPARA 7.84484
[BP] GO:0044281 small molecule metabolic process ABCG2, ADORA2A, AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HMGCR, PIM1, PPARA, TYR, XDH 7.42989
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 6.99173
[BP] GO:0023056 positive regulation of signaling ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 6.99114
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.9006
[BP] GO:0065008 regulation of biological quality ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, F10, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD17B1, HSD17B2, KDR, KIT, MET, PPARA, SRC, TERT, XDH 6.9006
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC, TERT 6.71437
[BP] GO:0050896 response to stimulus ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TOP1, TYR 6.69977
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HMGCR, HSD17B1, HSD17B2 6.46284
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA2A, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH 6.45184
[BP] GO:0010941 regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, FLT3, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 6.4479
[BP] GO:0060548 negative regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 6.34444
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP1, TYR, XDH 6.34444
[BP] GO:0043067 regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, FLT3, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 6.34444
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 6.34444
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADORA2A, CA2, CA7, CNR1, CNR2 6.26074
[BP] GO:0042493 response to drug ABCB1, ABCG2, ADORA2A, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, SRC, TOP1 6.24822
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT 6.15416
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.99481
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, F10, FABP3, FLT3, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, XDH 5.81311
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP1, TYR, XDH 5.76734
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, F10, FLT3, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 5.71713
[BP] GO:0009636 response to toxic substance ADORA2A, AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, SRC 5.62403
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, F10, FLT3, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 5.62403
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, XDH 5.54856
[BP] GO:0032501 multicellular organismal process ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, F10, FABP4, HMGCR, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TOP1, TYR 5.5437
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.5437
[BP] GO:0014070 response to organic cyclic compound ADORA2A, ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, RORC, SRC, TYR 5.5437
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, F10, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 5.53119
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.277
[BP] GO:0032502 developmental process ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FABP4, FLT3, FUT7, HMGCR, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TERT, TYR 5.16463
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, KIT, PPARA, RORC, SRC 5.11063
[BP] GO:0042981 regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, FLT3, HCAR2, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH 5.08004
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 5.05234
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, CNR1, CNR2, KIT 4.84908
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, CNR1, CNR2, KIT 4.84908
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, HMGCR, KIT, MET, PPARA 4.84712
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, FABP3, FLT3, IGF1R, KIT, MMP2, PPARA, SRC 4.75454
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 4.73871
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADORA2A, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HMGCR, HSD17B1, HSD17B2 4.69305
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADORA2A, APP, CNR1, CNR2, CYP19A1, DYRK1A, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 4.61898
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADORA2A, AKR1B1, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, F10, FABP4, FLT3, HMGCR, KDR, KIT, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 4.56554
[BP] GO:0044092 negative regulation of molecular function ADORA2A, ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.56554
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA2A, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.54179
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RORC, SRC, TERT 4.54075
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.48059
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.39851
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.39851
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.35157
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 4.31811
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.20529
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADORA2A, AURKB, BCL2, CA2, CA7, CNR1, HCAR2, HMGCR, KDR, SRC 4.14324
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, KIT, PPARA, RORC, SRC, TOP1 4.13717
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 4.13717
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, F10, FLT3, HMGCR, KDR, KIT, MET, PTPN1, SRC, XDH 4.13167
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TOP1, XDH 4.11281
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, F10, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH 3.98111
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.92911
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, TERT 3.8855
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.84264
[BP] GO:0010243 response to organonitrogen compound ADORA2A, AKR1B1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 3.84145
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, HSD17B2, TYR, XDH 3.84145
[BP] GO:0006793 phosphorus metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, TOP1, XDH 3.83173
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.83137
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, TERT 3.79759
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.79257
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.75767
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, RORC, SRC 3.74325
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, PPARA, SRC 3.70922
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.69392
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP1, TYR, XDH 3.69392
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.69392
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.65384
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.65384
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP1, TYR, XDH 3.63911
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.62709
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, FABP3, FABP4, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, XDH 3.62709
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.62709
[BP] GO:1901698 response to nitrogen compound ADORA2A, AKR1B1, APP, CNR1, CNR2, DNMT1, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 3.55547
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, F10, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, XDH 3.51136
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADORA2A, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, HSD17B2, KDR, KIT, MMP9, PIM1, PPARA, RORC, SRC, TYR 3.51136
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.51136
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.44549
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.41786
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 3.38959
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HMGCR, KIT, MMP2, PPARA, SRC, TERT, TYR 3.37665
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADORA2A, BCL2, CNR1, CNR2, CYP19A1, DYRK1A, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 3.37617
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTPN1, RORC, SRC, TERT 3.37289
[BP] GO:0001973 None ADORA1, ADORA2A, ADORA3 3.34617
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HCAR2, HMGCR, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 3.34433
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.31337
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MET, SRC, TOP1 3.29766
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, KIT, PPARA, SRC, TYR 3.27038
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.23776
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, FABP3, FABP4, FLT3, MET, SRC, TERT 3.23418
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, ADORA2A, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, F10, FLT3, FUT7, HMGCR, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TOP1, TYR, XDH 3.23216
[BP] GO:0051240 positive regulation of multicellular organismal process ADORA2A, APP, AXL, BCL2, CA2, CNR1, CYP1B1, HCAR2, HMGCR, KDR, KIT, MET, MMP12, MMP9, PIM1, SRC, TERT 3.23107
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.23034
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.23034
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DNMT1, DYRK1A, FABP4, HCAR2, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 3.19742
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.18543
[BP] GO:2000021 regulation of ion homeostasis ADORA1, ADORA2A, BCL2, CA2, CA7, KDR, SRC 3.18543
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 3.17926
[BP] GO:0009987 cellular process ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, FUT7, HCAR2, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP1, TYR, XDH 3.17072
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.11876
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, FABP3, FABP4, HCAR2, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, XDH 3.07421
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, FLT3, KIT, MET, PIM1, SRC, TYR 3.06613
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HMGCR, TYR 3.06443
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, ADORA2A, CA2, CA7 3.04103
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.00395
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP3, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.00395
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.96706
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CYP19A1, HCAR2, MMP12, SRC, TERT 2.93665
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91779
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADORA2A, CA2, CA7 2.91779
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.87565
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.84679
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.78522
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 2.77345
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.708
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, FABP4, FLT3, HMGCR, IGF1R, KIT, MMP9, PTPN1, SRC, TERT, XDH 2.69935
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.67293
[BP] GO:0031348 negative regulation of defense response ADORA1, ADORA2A, CNR2, CYP19A1, MMP12, PPARA 2.66315
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT 2.65144
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 2.63254
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.63189
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 2.63189
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.61771
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.61771
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADORA2A, APP, BCL2, CDC25B, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PPARA, PTPN1, SRC, XDH 2.59421
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT 2.58697
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, FABP4, FLT3, HMGCR, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 2.57927
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.56754
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.56574
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.55322
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.55322
[BP] GO:0031399 regulation of protein modification process ADORA1, ADORA2A, APP, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, HMGCR, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.55322
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.50423
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.49191
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.47954
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.47954
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.4706
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4706
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.46416
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, FLT3, HMGCR, KDR, KIT, PTPN1, SRC, XDH 2.46324
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, FABP4, HMGCR, KDR, MET, MMP12, PPARA 2.46308
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, ADORA2A, CNR2, CYP19A1, PPARA 2.4527
[BP] GO:0031347 regulation of defense response ADORA1, ADORA2A, CNR1, CNR2, CYP19A1, FABP4, MMP12, MMP2, PPARA, PTPN1, SRC 2.44737
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADORA2A, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.43954
[BP] GO:0035588 None ADORA1, ADORA2A, ADORA3 2.43738
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.43708
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.41958
[BP] GO:0042391 None ADORA1, ADORA2A, APP, BCL2, CNR1, CNR2, KDR, SRC 2.41099
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT 2.41099
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DYRK1A, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.40062
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DYRK1A, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.38794
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, SRC 2.37913
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADORA2A, APP, CA2, CA7 2.37913
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, FABP3, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.37437
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.37091
[BP] GO:0090087 None ACHE, ADORA1, ADORA2A, APP, CA2, CNR1, HCAR2, HMGCR, MMP12, PTPN1, SRC 2.36028
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC 2.3533
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.34687
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.34687
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.33389
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.32791
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.31338
[BP] GO:0051881 regulation of mitochondrial membrane potential ADORA2A, BCL2, KDR, SRC 2.30474
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29718
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.29613
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.29257
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, TERT 2.29257
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.29176
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.29164
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, KIT, MET, SRC, XDH 2.29164
[BP] GO:0009966 regulation of signal transduction ADORA1, ADORA2A, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, F10, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.26521
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26334
[BP] GO:0038171 None CNR1, CNR2 2.26135
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.26135
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HMGCR, SRC, TYR 2.2445
[BP] GO:0002682 regulation of immune system process ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, HCAR2, KIT, MMP12, MMP2, PTPN1, SRC 2.24188
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, CNR1, DNMT1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 2.24188
[BP] GO:0043549 regulation of kinase activity ADORA1, ADORA2A, APP, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.23619
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.21606
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, HSD17B2, KIT, MMP2, MMP9, SRC 2.2142
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, HSD17B2, KDR, MMP2, SRC 2.2142
[BP] GO:0051338 regulation of transferase activity ADORA1, ADORA2A, APP, AURKB, CDC25B, FABP4, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.21136
[BP] GO:0032880 regulation of protein localization ACHE, ADORA2A, APP, BCL2, CNR1, CSNK2A1, HCAR2, HMGCR, MMP12, PTPN1, SRC, TERT 2.16211
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, FLT3, HMGCR, IGF1R, KDR, KIT, PTPN1, SRC, XDH 2.1614
[BP] GO:0032846 positive regulation of homeostatic process ADORA2A, AURKB, CA2, CA7, CNR1, HCAR2 2.1614
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.15787
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.13617
[BP] GO:0002791 None ACHE, ADORA1, ADORA2A, CNR1, HCAR2, HMGCR, MMP12, SRC 2.13432
[BP] GO:0050730 None ADORA1, APP, FLT3, KIT, PTPN1, SRC 2.11778
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HMGCR, TERT 2.11778
[BP] GO:0043086 negative regulation of catalytic activity ADORA2A, APP, CNR1, CNR2, CSNK2A1, FABP4, HMGCR, IGF1R, MMP9, PTPN1, SRC 2.10183
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.10104
[BP] GO:0035587 None ADORA1, ADORA2A, ADORA3 2.10104
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HMGCR, KIT, MMP12, SRC, TYR 2.0944
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HMGCR, IGF1R, KIT, PTPN1, SRC 2.0944
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.08465
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.07402
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.0662
[BP] GO:0048869 cellular developmental process ACHE, ADORA2A, ALPL, APP, AXL, BCL2, CDC25B, CYP1A1, FABP4, FLT3, FUT7, HMGCR, KDR, KIT, MET, MMP2, MMP9, RORC, SRC, TERT 2.04573
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.02944
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.02944
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.02815
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.02815
[BP] GO:0043065 positive regulation of apoptotic process ADORA2A, BCL2, CNR1, CYP1B1, HCAR2, HMGCR, MMP9, SRC, XDH 2.02776
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, FLT3, RORC, SRC 2.02721
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, IGF1R, MMP2, MMP9, RORC, SRC 2.02721
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADORA2A, APP, BCL2, CA2, CA7, CNR1, MMP9 2.02721
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, KIT, MET, SRC 2.02372
[BP] GO:0031324 negative regulation of cellular metabolic process ADORA2A, APP, AURKB, BCL2, CNR1, CSNK2A1, DNMT1, DYRK1A, FABP4, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.02151
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.02151
[BP] GO:0019538 protein metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DYRK1A, F10, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TOP1 2.02138
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.02138
[BP] GO:0043068 positive regulation of programmed cell death ADORA2A, BCL2, CNR1, CYP1B1, HCAR2, HMGCR, MMP9, SRC, XDH 2.01305
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.01122
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.01097
[CC] GO:0005886 plasma membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, F10, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, SRC, TERT 3.46626
[CC] GO:0016020 membrane ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, FUT7, HCAR2, HMGCR, HSD17B2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, SRC, TERT, TYR 3.35885
[CC] GO:0044425 membrane part ABCB1, ABCG2, ACHE, ADORA1, ADORA2A, ADORA3, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, FUT7, HCAR2, HMGCR, HSD17B2, IGF1R, KDR, KIT, MET, PTPN1, SRC, TYR 2.8416
[CC] GO:0099056 None ADORA1, ADORA2A 2.4706
[CC] GO:0098889 None ADORA1, ADORA2A 2.4706
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA2A, ADORA3, APP, AXL, BACE1, CA4, CHRM2, CNR1, CNR2, F10, FLT3, IGF1R, KDR, MET 2.38193
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, HMGCR, HSD17B2, PTPN1 2.3815
[CC] GO:0044459 plasma membrane part ABCB1, ABCG2, ADORA1, ADORA2A, ADORA3, APP, AXL, BACE1, CA2, CA4, CA9, CHRM2, CNR1, CNR2, F10, FLT3, IGF1R, KDR, KIT, MET, SRC 2.3815
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 11.0734
[MF] GO:0003824 catalytic activity ABCB1, ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TOP1, TYR, XDH 10.7662
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0568
[MF] GO:0043167 ion binding ABCB1, ABCG2, ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, DYRK1A, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP1, TYR, XDH 8.78423
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.6649
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.38676
[MF] GO:0008144 drug binding ABCB1, ABCG2, ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC, TOP1 6.15742
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.62693
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.35295
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.05234
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.8014
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.7704
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, HSD17B2, TYR, XDH 4.73871
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.47636
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, F10, KIT, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TYR, XDH 4.31811
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.31811
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 4.27081
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.26621
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.13717
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.09588
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, F10, KIT, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TYR, XDH 4.02526
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.84264
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 3.74325
[MF] GO:0001609 None ADORA1, ADORA2A, ADORA3 3.65384
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.45732
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, SRC, XDH 3.34611
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.19615
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2, XDH 3.15786
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 3.08684
[MF] GO:0042802 identical protein binding ABCG2, ACHE, ADORA2A, APP, BCL2, CSNK2A1, DYRK1A, FLT3, HMGCR, IGF1R, KDR, KIT, MET, MMP9, TERT, TYR, XDH 2.95158
[MF] GO:0036094 small molecule binding ABCB1, ABCG2, ADORA1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, XDH 2.87565
[MF] GO:0008389 None CYP2A13, CYP2A6 2.85789
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 2.75246
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT, TOP1 2.74196
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HCAR2, IGF1R, KDR, KIT, MET, PPARA, RORC 2.63189
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DYRK1A, F10, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TOP1 2.56683
[MF] GO:0004949 None CNR1, CNR2 2.4706
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2 2.40062
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.29257
[MF] GO:0043168 anion binding ABCB1, ABCG2, APP, AURKB, AXL, CSNK2A1, DYRK1A, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, XDH 2.29176
[MF] GO:0000166 nucleotide binding ABCB1, ABCG2, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, XDH 2.27054
[MF] GO:1901265 nucleoside phosphate binding ABCB1, ABCG2, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FLT3, HMGCR, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, XDH 2.26971
[MF] GO:0035586 None ADORA1, ADORA2A, ADORA3 2.22176
[MF] GO:0004872 receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HCAR2, IGF1R, KDR, KIT, MET, PPARA, RORC 2.18087
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.10104
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA2A, ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HCAR2, IGF1R, KDR, KIT, MET, PPARA, RORC 2.05638
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HCAR2, IGF1R, KDR, KIT, MET 2.02138
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA2A, ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, HCAR2, IGF1R, KDR, KIT, MET 2.02138
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.00875


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.3687
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.9931
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.01
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, AKR1B1, HMGCR, TYR, CYP19A1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.2874
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 4.2874
Rap1 signaling pathway_Homo sapiens_hsa04015 ADORA2A, SRC, CNR1, KIT, KDR, MET, IGF1R 4.2874
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.2874
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2874
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 3.5406
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.4472
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.1761
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0615
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, ADORA2A, CNR2, CNR1, ADORA3, ADORA1 2.7945
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2626
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, ABCG2 3.2438
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, ADORA2A, ADORA1, PPARA 2.5926
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KIT, KDR, BCL2, MET, IGF1R 2.4107
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.5862
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0554
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.2007
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7219
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.3583
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.2007
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.212
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.769
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9512
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.7775
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.6983
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 1.6815
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.511
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6444
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.4594
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0742
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3218
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3707
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0657
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.228
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0245
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2431
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0172
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0742
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1614
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0023
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3386
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.2413
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9743
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0573
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 0.961
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9359
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.9055
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9359
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7605
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.833
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.7462
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.511
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, ADORA2A 0.7147
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6385
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7462
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7167
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.6142
ABC transporters_Homo sapiens_hsa02010 ABCB1, ABCG2 1.5252
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.769
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2615
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2615
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3239
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7284
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3592
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3692
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6694
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3499
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4106
Parkinson's disease_Homo sapiens_hsa05012 ADORA2A 0.4106
Platelet activation_Homo sapiens_hsa04611 SRC 0.4242
Alcoholism_Homo sapiens_hsa05034 ADORA2A 0.3571
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4242
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4106
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4433
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4111
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4106
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4242
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3498
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4242
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4111
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4106
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4035
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4002
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4106
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3883
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4836
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.4094
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4242
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADORA2A 0.4242
Axon guidance_Homo sapiens_hsa04360 MET 0.4196
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4706
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4734
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4768
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4836
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.4706
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4768
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4836
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4836
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4836
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4768
Gap junction_Homo sapiens_hsa04540 SRC 0.4836
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4836
Peroxisome_Homo sapiens_hsa04146 XDH 0.486
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5261
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5204
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5002
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5508
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5321
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5508
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9512
Glioma_Homo sapiens_hsa05214 IGF1R 0.5508
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5501
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5508
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5508
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5508
Shigellosis_Homo sapiens_hsa05131 SRC 0.5508
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5508
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.604
Malaria_Homo sapiens_hsa05144 MET 0.6142
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.637
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7167
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7462
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7605
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7849
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.753
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7762
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8404
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9851


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)