TCM Prescription: Wu Ren Run Chang Pills



Prescription Description
Prescription IDTCMF5554
Pinyin NameWu Ren Run Chang Wan
Chinese Name五仁润肠丸
English NameWu Ren Run Chang Pills
Function Description便秘
IndicationsConstipation disorder, Constipation
Disease ICD-11 Category SA57 [Constipation disorder (TM1), 便秘 (TM1) ];
ME05.0 [Constipation, 便秘 ];
Human Tissues Associated with IndicationLarge Intestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH1005 Cannabis sativa 火麻仁 TCMH1005 ITSAJ4165-14
TCMH2536 Prunus japonica 郁李仁 TCMH2536 ITSAJ4487-14
TCMH121 Biota orientalis 柏子仁 TCMH121
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2037 pine nut 松子仁 TCMH2037
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9602
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9602
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6119
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 11.9967
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6269
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 10.8814
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 10.3205
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HTR2B, HTR2C, PIK3CA, PPARA, PPARD, PTGS1, PTGS2, XDH 10.2506
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CHRM1, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, XDH 10.0519
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 10.0519
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 9.43886
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 8.68306
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB 8.52614
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2C, PPARD 8.52614
[BP] GO:0097746 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 8.31498
[BP] GO:0035296 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 8.31498
[BP] GO:0050880 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 8.06997
[BP] GO:0035150 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 8.05046
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.86337
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.75431
[BP] GO:0006690 icosanoid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.61053
[BP] GO:0003018 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 7.45989
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARD, PTGS2 7.43432
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PPARD, PTGS2 7.43432
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.3021
[BP] GO:0006631 fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS1, PTGS2 7.12981
[BP] GO:0099536 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 7.10869
[BP] GO:0099537 None CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 7.10869
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PPARD, PTGS2 7.01572
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.94305
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD11B2, HSD17B1, PPARD 6.84363
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.8036
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARD 6.62273
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 6.55025
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 6.53521
[BP] GO:0003013 None ADORA1, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 6.44703
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 6.33666
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.28033
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, PIK3CA, PIK3CB, PPARD, PTGS1, PTGS2 6.23558
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2 6.22412
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, NQO2, PPARD, PTGS1, PTGS2, XDH 6.19938
[BP] GO:0007268 None CHRM1, CHRM2, CHRM4, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.19938
[BP] GO:0098916 None CHRM1, CHRM2, CHRM4, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.19938
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 5.99101
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 5.96297
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1B, HTR5A, MMP2, PIK3CA, PPARA, PPARD, PTGS2 5.92735
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.77314
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2 5.70579
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1 5.67306
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, ESR1, HTR2A, HTR2B, HTR2C 5.48133
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.48133
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARD 5.40611
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CHRM1, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, MMP12, MMP2, MMP9, PPARD, PTGS1, PTGS2, XDH 5.35084
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 5.30417
[BP] GO:0090066 None ADORA1, ALOX15, CHRM1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 5.23628
[BP] GO:0032787 None ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS1, PTGS2 5.08314
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA6, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 5.08314
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.88743
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, MMP2, PPARA, PTGS2 4.88654
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, PTGS2 4.82601
[BP] GO:0007154 None ADORA1, BCL2, CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 4.77845
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.77058
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CHRM1, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, MMP12, MMP2, MMP9, PPARD, PTGS2 4.6843
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.55842
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 4.54312
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PPARD, PTGS2 4.47819
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CHRM1, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, MMP1, MMP12, MMP2, MMP9, PIK3CA, PPARA, PPARD, PTGS2 4.44959
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.44415
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C 4.28373
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM4, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.26932
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CNR1, HCAR2, HTR2A, HTR2B, HTR2C, PIK3CB, PTGS2 4.23623
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.21506
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.21506
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 4.20211
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 4.20211
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 4.11835
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.06282
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 4.06282
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 4.01829
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.95572
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.95572
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 3.86782
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PPARD, PTGS2 3.85249
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.73436
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.73436
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.73436
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CHRM1, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PPARD, PTGS2 3.72908
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1 3.68002
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.68002
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.65428
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PPARD 3.61861
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1 3.61698
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA, PPARD 3.57284
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PTGS2 3.56924
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1 3.56174
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR2A, HTR2C, PPARD 3.52822
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.52822
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9, PTGS2 3.51816
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, BCL2, CNR1, CSNK2A1, CYP1B1, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 3.4894
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PTGS2 3.4894
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD 3.4881
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, HTR2A, HTR2B, HTR2C, PPARA, PPARD 3.43532
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, PIK3CA, PIK3CB 3.37356
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PPARD 3.3287
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CHRM1, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 3.31398
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PPARD, PTGS2 3.30307
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C 3.30307
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27062
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PPARD, PTGS2 3.25897
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARD, PTGS2 3.24192
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.22028
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 3.20366
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C 3.20291
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.15643
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D 3.15643
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CBR1, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2 3.12861
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, XDH 3.08628
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2 3.07222
[BP] GO:0007566 embryo implantation MMP2, MMP9, PPARD, PTGS2 3.06104
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.98741
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.98741
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 2.97345
[BP] GO:0007208 None HTR2A, HTR2C 2.89418
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2 2.89056
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 2.88955
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, XDH 2.87729
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.86168
[BP] GO:0009056 catabolic process ACHE, ADORA1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, PPARD, XDH 2.84775
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, MMP2, MMP9, PIK3CA, PPARD, PTGS2 2.79928
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PPARD, PTGS2 2.74859
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 2.73163
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS1, PTGS2 2.72539
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.69811
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.69342
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, HTR2B, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 2.68758
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PPARD 2.67678
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, XDH 2.66709
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.66709
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HCAR2, HTR2B, PIK3CA, PPARA 2.62054
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 2.58361
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, XDH 2.58361
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA 2.5797
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, PPARD 2.55713
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, MMP2, PIK3CA, PPARD, PTGS2 2.55713
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, XDH 2.55204
[BP] GO:0090407 organophosphate biosynthetic process ACHE, ALOX15, CSNK2A1, HTR2B, HTR2C, PIK3CA, PIK3CB, PPARD, PTGS2 2.5358
[BP] GO:0032496 response to lipopolysaccharide ALPL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PTGS2 2.49867
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, BCL2, CA2, CA7, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, XDH 2.48741
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48741
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.46055
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARD 2.44444
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PPARD, PTGS2 2.40475
[BP] GO:0045600 positive regulation of fat cell differentiation HTR2A, HTR2C, PPARD, PTGS2 2.39406
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.38561
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.38561
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.37492
[BP] GO:0008283 cell proliferation ACHE, BCL2, CHRM1, CHRM4, CYP1A1, ESR1, FLT3, HTR1A, PIK3CB, PPARD 2.37492
[BP] GO:0043436 oxoacid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS1, PTGS2 2.36861
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.35117
[BP] GO:0002237 response to molecule of bacterial origin ALPL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PTGS2 2.34903
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.3317
[BP] GO:0050995 None ADORA1, CNR1, HCAR2 2.3317
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, CNR1, HCAR2, HTR2B, HTR2C, MMP12, PPARD, PTGS2 2.30798
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.30798
[BP] GO:0006082 organic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARD, PTGS1, PTGS2 2.30798
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A, PPARD 2.29769
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1 2.29156
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.29156
[BP] GO:0007610 None BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 2.29156
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.29156
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29156
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.29156
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.27169
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, PTGS2 2.27169
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.25145
[BP] GO:0038171 None CNR1, CNR2 2.25145
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.25145
[BP] GO:0014827 None HTR1D, HTR2B 2.25145
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.25145
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.25145
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.25145
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, FLT3, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2, XDH 2.23766
[BP] GO:0016477 cell migration CNR2, CYP1B1, FUT7, HTR2B, HTR6, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD 2.23525
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, CNR2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.18116
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, PTGS2 2.12021
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, PIK3CA, PPARA, PPARD 2.11739
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, HCAR2, PIK3CB, PTGS2 2.1143
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.11077
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.10493
[BP] GO:0002791 None ACHE, ADORA1, CNR1, HCAR2, HTR2B, HTR2C, MMP12, PPARD 2.07967
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.07132
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.07132
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.07132
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.06888
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C 2.06888
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, BCL2, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HTR5A, MMP9, PIK3CA, PPARA, PPARD, PTGS2 2.06537
[BP] GO:0071502 None HTR1B, HTR2B 2.06367
[BP] GO:0051952 None ADORA1, CNR1, HTR1B, HTR2A 2.05223
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.03857
[BP] GO:0007205 None CHRM1, HTR1B, HTR2B 2.03857
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CHRM1, CHRM4, CYP19A1, CYP1B1, HTR1D, MMP9, PPARD, PTGS2 2.02116
[BP] GO:0009266 None ADORA1, HTR1B, HTR2A, HTR2B, PTGS2 2.00214
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.00214
[BP] GO:0002209 None BCL2, HTR1A, HTR2C 2.00214
[BP] GO:0001662 None BCL2, HTR1A, HTR2C 2.00214
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.00182
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, CA4, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.38124
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, PTGS1, PTGS2 5.19457
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.96572
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB 4.23623
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.20211
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTGS2 3.74768
[MF] GO:0099528 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 21.2977
[MF] GO:0008227 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.7171
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.9602
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9602
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.9602
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.5835
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 17.5835
[MF] GO:0030594 None CHRM1, CHRM2, CHRM4, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.1499
[MF] GO:0046914 transition metal ion binding ALOX15, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PPARD, XDH 11.9863
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.9206
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6869
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.458
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3585
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PPARD, PTGS1, PTGS2, XDH 8.52614
[MF] GO:0043167 ion binding ACHE, ALOX15, ALPL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, XDH 8.23277
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, PPARD 8.05017
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 8.0104
[MF] GO:0004872 receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, PPARD 7.10869
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.06273
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, PPARD 6.88158
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.84363
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PPARD 6.75961
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 6.52611
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 6.43507
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 6.43507
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, CHRM1, CHRM2, CHRM4, CNR1, CNR2, ESR1, FLT3, HCAR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA, PPARD 6.40853
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.66957
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.58002
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.43417
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.08314
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 5.05725
[MF] GO:0005506 iron ion binding ALOX15, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.98749
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX15, ALPL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PTGS1, PTGS2, XDH 4.3468
[MF] GO:0008144 drug binding ACHE, CHRM1, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, NQO2, PIK3CA, PIK3CB, PPARA, PPARD 4.32622
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.21506
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.2101
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.97106
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.23139
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD11B1, HSD11B2, HSD17B1, XDH 3.17494
[MF] GO:0046872 metal ion binding ALOX15, ALPL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PPARD, PTGS1, PTGS2, XDH 3.00919
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.89418
[MF] GO:0003845 None HSD11B1, HSD11B2 2.89418
[MF] GO:0008389 None CYP2A13, CYP2A6 2.89418
[MF] GO:0071886 None HTR2A, HTR2C 2.89418
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.55713
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.55636
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.48741
[MF] GO:0004949 None CNR1, CNR2 2.48741
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HSD11B1, HSD11B2, HSD17B1 2.38362
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.11077
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1 2.11077
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1 2.03857


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, HTR1E, CHRM4, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 16.8768
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7 16.8768
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.0126
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, HTR4, HCAR2, HTR6, PIK3CA, ADORA1, PPARA 11.9439
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 8.3736
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, CHRM1, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 7.149
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.942
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 7.2909
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, PIK3CA, CHRM4, BCL2, PIK3CB 6.1665
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.5309
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, PPARD 4.4782
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1 5.2905
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, HTR2B, HTR2C, PIK3CB, HTR2A 3.9374
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH 3.8049
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.6202
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 3.9374
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIK3CB, PPARD 3.6655
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.6082
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX15, PTGS2, PTGS1 3.5664
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.0909
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIK3CB 2.8471
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.0513
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 2.7053
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.73
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, PIK3CA, CHRM4, PIK3CB 2.6308
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6455
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, BCL2, PIK3CB, MMP9 2.3684
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.1904
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, CYP1B1, PTGS2, MMP9 2.1066
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PIK3CB, PTGS2 2.4141
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.8586
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8471
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.4073
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.8471
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, PIK3CB, ESR1 2.2702
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.9586
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, BCL2, PIK3CB 1.927
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB 2.3483
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3684
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB 2.0632
Gap junction_Homo sapiens_hsa04540 HTR2B, HTR2C, HTR2A 2.0664
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB 1.927
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0195
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.8748
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, PIK3CB, ESR1 1.797
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, BCL2, PIK3CB 1.797
Platelet activation_Homo sapiens_hsa04611 PIK3CA, PIK3CB, PTGS1 1.7744
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7857
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6515
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.6799
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.6698
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.6014
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.5926
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIK3CB 1.5589
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PIK3CB, PTGS2 1.5589
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, CNR1, PIK3CB 1.319
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, BCL2, PIK3CB 1.362
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, PIK3CB 1.2507
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3 0.2493
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3644
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3744
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3548
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.364
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB 1.2252
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2507
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0389
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB 1.2476
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, PIK3CB 1.2928
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4375
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB 1.0378
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.0311
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6492
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.2168
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB 1.0067
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4388
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 1.0137
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2252
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB 1.0819
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 1.0067
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, PIK3CB 0.786
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2168
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.0006
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.8824
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB 1.4568
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.2038
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9 0.8703
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1987
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4114
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.2168
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.2038
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.4624
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4568
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4114
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB 1.422
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PIK3CB 0.8471
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5088
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.422
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.4568
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.3635
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.549
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5926
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.565
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.5776
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5645
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5776
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5589
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5776
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.4331
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5776
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5776
Peroxisome_Homo sapiens_hsa04146 XDH 0.5945
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6351
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6698
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6351
Adherens junction_Homo sapiens_hsa04520 CSNK2A1 0.6351
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6415
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6438
Bile secretion_Homo sapiens_hsa04976 CA2 0.6398
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.669
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6639
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6972
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7513
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9586
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7802
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1066
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9311
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9219
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.8726
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.9129
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4666
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9821
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9706
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1987


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)