TCM Prescription: Wu Di Dan Capsules



Prescription Description
Prescription IDTCMF5323
Pinyin NameWu Di Dan Jiao Nang
Chinese Name无敌丹胶囊
English NameWu Di Dan Capsules
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH2334 Dipsacus japonicus 续断 TCMH2334 ITSAC1509-14
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH2044 Caesalpinia sappan 苏木 TCMH2044 ITSAJ4578-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH700 Drynaria fortunei 骨碎补 TCMH700 GBVM3977-11
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH2348 Sanguis draconis 血竭 TCMH2348
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH2267 Periploca sepium 香加皮 TCMH2267 ITSAJ4400-14, GBVP4570-15
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT666 VCP Transitional endoplasmic reticulum ATPase Transporter P55072
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2712
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, SRC 11.0123
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5951
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, NR3C1, PPARA, PPARG, RORC, SRC, TYR 10.4072
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AR, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GPER1, GRIK5, GRM5, HSD17B2, HSP90AB1, IGF1R, MMP2, MMP9, NR3C1, PPARA, PPARG, RORC, SRC, TYR 10.3813
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, SRC 9.86297
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, PGR, PIM1, PPARA, PPARG, RORC, SRC 9.64811
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALOX15, ALPL, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, RORC, SRC, TYR 9.4132
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.38418
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, NR3C1, PPARG, RORC, SRC, TYR 9.37754
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, MET, PPARA, PPARG, SLC1A1, SRC, XDH 9.13182
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, PPARG 8.56541
[BP] GO:0014070 response to organic cyclic compound ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GPER1, HSP90AB1, NR3C1, PPARG, RORC, SRC, TYR 8.40157
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, PPARA, PPARG, SRC, TYR 7.90395
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GPER1, GRM5, IGF1R, MMP2, NR3C1, PPARA, PPARG, SRC 7.8219
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AR, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, NR3C1, PPARG, RORC, SRC 7.70723
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, PIM1, PPARA, PPARG, TYR, XDH 7.65779
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC 7.61036
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM5, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, RORC, SRC 7.5312
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GPER1, NR3C1, PPARA, PPARG, SRC 7.30484
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, ADRB1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, MET, PPARG, SRC 6.78574
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.63816
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 6.62372
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC 6.54816
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1 6.32991
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, HSP90AB1, NR3C1, PPARG, RORC, SRC 6.24884
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SRC, XDH 6.138
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, AR, AXL, BCL2, CA1, CA2, CACNA1C, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SRC 6.0375
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, XDH 6.02904
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, ALOX15, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GPER1, GRM1, HCAR2, HSP90AB1, KDR, MET, MMP9, PTPN1, SRC, XDH 5.99949
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARG, PTPN1, SRC, XDH 5.97809
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, ALOX15, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, GPER1, GRM1, HCAR2, HSP90AB1, KDR, MET, MMP9, PTPN1, SRC, XDH 5.97809
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, FLT3, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PTPN1, SRC, XDH 5.92975
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD17B1, HSD17B2 5.83798
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, FLT3, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PTPN1, SRC, XDH 5.80748
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARG, PTPN1, RORC, SRC 5.60821
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 5.59268
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 5.57415
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 5.57415
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 5.5498
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PGR, PIM1, PPARG, SRC, XDH 5.45062
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPER1, GRIK5, HCAR2, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARG, PTPN1, SRC, XDH 5.42881
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, GPER1, HCAR2, HSD11B1, HSD17B1, HSD17B2 5.4168
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, TYR, XDH 5.30315
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.28081
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, ALOX15, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, PTPN1, RORC, SRC, XDH 5.17437
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, NR3C1, PGR, SRC 5.12474
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, PPARG, SLC1A1 5.09859
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.0969
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 5.0969
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, EGFR, GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 5.0969
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 5.06066
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, PPARA, PPARG 5.05565
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AR, AXL, CYP1B1, EGFR, ESR1, GPER1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PPARG, RORC, SRC 5.00927
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, AR, AXL, BCL2, CYP1B1, EGFR, ERBB2, FLT3, GPER1, GRM1, KDR, MET, PTPN1, SRC, XDH 4.98456
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, GPER1, GRM1, GRM5, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 4.90779
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 4.89057
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 4.87824
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSP90AB1, KDR, MMP9, PGR, PIM1, PPARA, PPARG, RORC, SRC, TYR 4.87824
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, ALOX15, AR, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, PTPN1, RORC, SRC, XDH 4.8764
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, ALPL, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, GRIK5, GRM1, GRM5, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PPARG, PTPN1, RORC, SRC, TYR 4.85058
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, TYR, XDH 4.85058
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 4.83961
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, PPARG, TYR, XDH 4.81645
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.78542
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 4.72683
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALOX15, ALPL, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSP90AB1, KDR, MET, MMP2, MMP9, PGR, PIM1, PPARA, PPARG, RORC, SRC, TYR 4.71433
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSP90AB1, PGR, PPARG, SRC 4.69503
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, ALOX15, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, PTPN1, RORC, SRC, XDH 4.69006
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.60769
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.58084
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, GPER1, GRIK5, GRM1, GRM5, MET, PPARG 4.52449
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, FLT3, GPER1, GRM1, GRM5, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 4.51554
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.48712
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PGR, PPARA, PPARG, RORC, SRC 4.43087
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.42745
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, GPER1, NR3C1, SRC 4.37042
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.35591
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, PTPN1, RORC, SRC, XDH 4.34244
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.33416
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.33416
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSP90AB1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 4.3068
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 4.29714
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP4, FLT3, GPER1, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.29714
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, GPER1, GRM1, HSP90AB1, KDR, MET, MMP9, PTPN1, SRC, XDH 4.25298
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, FABP4, GPER1, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 4.2439
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, FLT3, GPER1, GRM1, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 4.18702
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AR, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, GPER1, GRIK5, GRM5, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARA, PPARG, PTPN1, SRC 4.08937
[BP] GO:0071383 None AR, EGFR, FLT3, GPER1, NR3C1, SRC 4.06377
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 4.04569
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, PPARG, SRC 4.03041
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, ERBB2, PPARA 4.01534
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, FABP4, FLT3, GPER1, GRM1, HSP90AA1, HSP90AB1, KDR, MET, MMP2, MMP9, PTPN1, SRC, XDH 4.00678
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.9965
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, AR, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, MET, MMP9, PPARG, PTPN1, SRC, XDH 3.91898
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, AR, EGFR, ERBB2, FLT3, GPER1, GRM1, KDR, PTPN1, SRC, XDH 3.89787
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, PPARG, SRC 3.8763
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, HSP90AB1, KDR, NR3C1, PPARG, SRC 3.7669
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.73857
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, PPARG, SRC 3.72789
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, NR3C1, PGR, PPARA, PPARG, RORC, SRC 3.69534
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, GPER1, GRM1, GRM5, HSP90AB1, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.67935
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, ESR1, FLT3, GPER1, NR3C1, PPARG, RORC, SRC 3.67454
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 3.67454
[BP] GO:0007154 None ADORA1, ADRB1, AR, AXL, BCL2, CACNA1C, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, PPARG, SLC1A1 3.67366
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, IGF1R, MMP9, PPARG, PTPN1, SRC, XDH 3.63524
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, PIM1, SRC, TYR 3.61166
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, GPER1, HCAR2, PPARA, PPARG, RORC, SRC 3.61166
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, GPER1, KDR, SRC 3.60995
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HSP90AA1, HSP90AB1, MMP2, PPARA, PPARG, SRC, TYR 3.60957
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, GPER1, IGF1R, KDR, MMP2, MMP9, PIM1 3.59254
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, GPER1, IGF1R, KDR, MET, MMP9, PPARG, SRC 3.54512
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.54512
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.54512
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.50341
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSP90AA1, HSP90AB1, IGF1R, MET, NR3C1, PGR, PPARA, PPARG, PTPN1, RORC, SRC 3.48383
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, EGFR, GPER1, HCAR2, KDR, SRC 3.44171
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, SLC1A1 3.44171
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AR, EGFR, ERBB2, ESR1, FLT3, GPER1, GRM5, IGF1R, MMP2, NR3C1, PPARG, SRC 3.44171
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GPER1, NR3C1, SRC 3.44171
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.44171
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.43039
[BP] GO:0007188 None ADORA1, ADRB1, GPER1, GRM1, GRM3, GRM5, GRM8 3.43035
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, AR, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, GPER1, GRM1, GRM5, HSP90AB1, KDR, MMP9, PPARG, PTPN1, SRC, XDH 3.32068
[BP] GO:0042391 None ADORA1, BCL2, CACNA1C, GPER1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.29161
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, GPER1, IGF1R, KDR, MET, MMP9, PPARG, SRC 3.29161
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, HSP90AA1, HSP90AB1, IGF1R, MET, NR3C1, PGR, PPARA, PPARG, RORC, SRC 3.29161
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, FLT3, GPER1, GRM1, GRM5, HSP90AB1, KDR, MMP9, PTPN1, SRC, XDH 3.27091
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.27047
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.25806
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, AR, EGFR, ERBB2, FLT3, GPER1, GRM1, IGF1R, KDR, PTPN1, SRC, XDH 3.23636
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, HSP90AB1, MMP2, MMP9, PGR, PPARG, SRC 3.23411
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GRM3, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 3.19321
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AR, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, NR3C1, PGR, PPARA, PPARG, RORC, SRC 3.18163
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.15982
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.15329
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9 3.14328
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, HSP90AB1, RORC 3.14328
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, HSP90AA1, HSP90AB1, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC, XDH 3.12951
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, ESR1, FLT3, GPER1, GRM1, GRM5, HSP90AB1, KDR, MMP9, PPARG, PTPN1, SRC, XDH 3.12166
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.09473
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.09473
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SRC, TYR, XDH 3.0609
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GPER1, GRIK5, HSP90AA1, HSP90AB1, SLC1A1 3.05745
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, GPER1, GRIK5, GRM5, HCAR2, HSP90AB1, MMP9, PPARA, PPARG, PTPN1, SRC 3.04923
[BP] GO:0007187 None ADORA1, ADRB1, GPER1, GRM1, GRM3, GRM5, GRM8 3.03675
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, GPER1, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TYR 3.01009
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, PPARG, PTPN1, SRC, XDH 2.99927
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.98096
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, PPARG, PTPN1, SRC 2.98096
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, ERBB2, GPER1, IGF1R, KDR, MET, MMP9, PPARG, SRC 2.97105
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, GPER1, IGF1R, KDR, MET, MMP9, PPARG, SRC 2.95456
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, GPER1, MMP2, MMP9, PPARG 2.8999
[BP] GO:0050801 ion homeostasis ABCG2, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GPER1, GRM1, GRM5 2.8784
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.87408
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 2.87408
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.85234
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.85033
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, AR, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, GPER1, GRM1, GRM5, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.84033
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AR, AURKB, BCL2, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, FABP4, GPER1, GRM3, GRM8, HCAR2, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PGR, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.81094
[BP] GO:0009115 None AOX1, XDH 2.81094
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, PTPN1, SRC 2.79848
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SRC 2.79625
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HSP90AB1, KDR, NR3C1, SRC 2.79625
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.78567
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, BCL2, CYP19A1, EGFR, ERBB2, ESR1, ESR2, GPER1, IGF1R, MET, MMP9, PPARA, PPARG, PTPN1, SRC, XDH 2.78359
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3, PPARG 2.78359
[BP] GO:0038128 None EGFR, ERBB2, HSP90AA1, SRC 2.78274
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, SRC 2.77745
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.76987
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG, TYR 2.75179
[BP] GO:0023052 None ADORA1, ADRB1, AR, CACNA1C, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1 2.74061
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG 2.73522
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, GPER1, GRM5, HSP90AB1, IGF1R, MMP2, PPARA, PPARG, SRC, TYR 2.72528
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, GPER1, MET, SRC, XDH 2.71164
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.70839
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRB1, ALOX15, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.70245
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSP90AA1, MMP1, MMP2, MMP9, SRC, XDH 2.66426
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.60345
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, AR, AXL, BCL2, CA2, CACNA1C, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, GPER1, GRM1, HCAR2, HSP90AB1, KDR, MET, MMP9, PIM1, PPARG, SLC1A1, SRC, XDH 2.57332
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, HSP90AA1, KDR, SRC 2.56381
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.53986
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, ALOX15, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.5364
[BP] GO:1905475 None AR, BCL2, CSNK2A1, EGFR, ERBB2, GPER1 2.53636
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, GRM3, GRM8, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.50979
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HSP90AB1, PTPN1, SRC 2.5049
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.50225
[BP] GO:0007267 None ADORA1, ADRB1, AR, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1 2.49997
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, EGFR, ERBB2, ESR1, ESR2, GPER1, IGF1R, MET, MMP9, PPARG, PTPN1, SRC, XDH 2.47595
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.47199
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, EGFR, ERBB2, ESR1, ESR2, GPER1, IGF1R, MET, MMP9, PPARG, PTPN1, SRC, XDH 2.46307
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, SRC 2.44663
[BP] GO:0098771 inorganic ion homeostasis ABCG2, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, GPER1, GRM1, GRM5 2.41216
[BP] GO:0099566 None GRM1, GRM5 2.41216
[BP] GO:0060748 None AR, PGR 2.41216
[BP] GO:0046110 None AOX1, XDH 2.41216
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41216
[BP] GO:1901184 None ADORA1, EGFR, ERBB2, GPER1, MMP9 2.41204
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PTPN1, SRC 2.38612
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.35319
[BP] GO:0010676 None ESRRB, GPER1, PPARA, SRC 2.35259
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.34521
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, FABP4, FLT3, GPER1, GRM1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PPARG, PTPN1, SRC, XDH 2.34521
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HSP90AA1, HSP90AB1, XDH 2.33313
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, HSP90AB1, PTPN1, SRC 2.31056
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, IGF1R, PTPN1, SRC 2.31056
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC 2.31056
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, GPER1, HSP90AB1, MMP2, PPARA, PPARG, PTPN1, SRC 2.30507
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.30169
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, PTPN1, SRC 2.29765
[BP] GO:0051098 regulation of binding AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PPARG, SRC 2.29552
[BP] GO:0032870 cellular response to hormone stimulus AR, EGFR, ESR1, FLT3, GPER1, NR3C1, PPARG, SRC 2.29552
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRB1, ALOX15, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.29513
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.2838
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.26759
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRB1, ALOX15, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPER1, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, XDH 2.25304
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GPER1, GRM5, IGF1R, PPARA, PPARG, SRC 2.25304
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HSP90AB1, PTPN1, SRC 2.23772
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, MMP9, PPARG, RORC 2.21766
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SRC 2.20645
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, HSP90AB1, MET, PPARA 2.19989
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, PTPN1, SRC 2.19107
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.18631
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CYP19A1, ERBB2, ESR1, ESRRA, GPER1, HCAR2, HSP90AA1, HSP90AB1, MMP2, PPARG, PTPN1, SRC 2.18478
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.17397
[BP] GO:0006145 None AOX1, XDH 2.17397
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17397
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, AR, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, GPER1, HCAR2, KDR, MET, MMP9, PIM1, PPARG, SLC1A1, SRC 2.17397
[BP] GO:0071384 None EGFR, FLT3, GPER1, NR3C1 2.16586
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, GPER1, PPARA, PPARG 2.16586
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.14749
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.14406
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, EGFR, ERBB2, GPER1, HCAR2, HSP90AB1, PPARG, SRC 2.12951
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, TYR 2.12191
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, EGFR, ERBB2, GPER1, KDR, PTPN1, SRC 2.11339
[BP] GO:0035902 response to immobilization stress CYP1A1, CYP1A2, PPARG 2.09567
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.09567
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, ALOX15, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, FLT3, GPER1, GRM1, HSP90AB1, IGF1R, KDR, MET, MMP9, PPARG, PTPN1, SRC, XDH 2.08821
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, GPER1 2.07685
[BP] GO:0010675 None ESRRB, GPER1, PPARA, RORC, SRC 2.07685
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC 2.07346
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.07168
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HSP90AB1, IGF1R, PTPN1, SRC 2.05462
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, SRC 2.04877
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SRC, TYR, XDH 2.03493
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, GPER1 2.03493
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.02122
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, PPARA, PPARG, TYR 2.0152
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.00828
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.00828
[CC] GO:0098590 plasma membrane region ABCG2, ADORA1, CA2, CA4, CA9, EGFR, ERBB2, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, MET, SLC1A1, SRC 6.32249
[CC] GO:0042734 None GPER1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.46641
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, ESR1, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SRC 4.20616
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALOX5, ALPL, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, SLC1A1, SRC, TYR 4.05141
[CC] GO:0043235 receptor complex ABCG2, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R, NR3C2 4.00615
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, ADRB1, ALOX15, AXL, CA2, CA4, CA9, CACNA1C, EGFR, ERBB2, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, SLC1A1, SRC 3.99803
[CC] GO:0014069 None ADORA1, CACNA1C, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 3.73857
[CC] GO:0099572 None ADORA1, CACNA1C, GPER1, GRIK5, GRM1, GRM3, GRM5, SRC 3.73857
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ADRB1, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, NR3C2, PTPN1, SLC1A1, SRC, TYR 3.44171
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2, HSP90AB1 2.99927
[CC] GO:0097060 None GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.75535
[CC] GO:0044456 None ACHE, ADORA1, CACNA1C, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 2.75535
[CC] GO:0044444 cytoplasmic part ABCG2, ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AR, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GPER1, GRIA2, GRIA4, GRIK5, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARG, PTPN1, SRC, TYR, XDH 2.59708
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GPER1, GRIA2, HSD11B1, HSD17B2, NR3C2 2.29756
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, TYR, XDH 20.0152
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.7506
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC 13.3377
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, NR3C1, NR3C2, PGR, RORC, SHBG 11.3638
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC 11.0799
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PGR, PPARA, PPARG, RORC 11.0123
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PGR, PPARA, PPARG, RORC 11.0123
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PPARG, PTPN1, RORC 11.0077
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.5951
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, SRC, TYR, XDH 10.3436
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC 10.1019
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC 9.79223
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.4132
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AR, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC 9.16807
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.1058
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HSD17B1, NR3C1, NR3C2, PGR, PPARA, PPARG, RORC, SHBG 7.13769
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, TYR, XDH 6.68522
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.43345
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PPARG, PTPN1, RORC, SLC1A1, TYR, XDH 6.41468
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 6.41305
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, GPER1, HSD17B1, IGF1R, NR3C1, SHBG 6.13439
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.9273
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.73443
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.56004
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSP90AA1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 5.38039
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 5.15666
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.09859
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.09859
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, KDR, MET, SRC 4.96231
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARG 4.83071
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, FLT3, GPER1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARG 4.83071
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.66611
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 3.99803
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, PIM1, PPARA, PPARG, SRC 3.9965
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.90437
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.82652
[MF] GO:0042802 identical protein binding ABCG2, ACHE, AOX1, BCL2, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, FLT3, GRIK5, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, PGR, PPARG, TYR, XDH 3.81453
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 3.74551
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.71791
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.44171
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA, PPARG, PTPN1 3.29161
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.22303
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 3.09542
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, MET, PPARG, PTPN1 3.07046
[MF] GO:0019899 enzyme binding ADRB1, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRB, GRM5, HSP90AA1, HSP90AB1, MET, NR3C1, PGR, PPARA, PPARG, PTPN1, SRC 3.03331
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.98096
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.97511
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.84532
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81094
[MF] GO:0008389 None CYP2A13, CYP2A6 2.81094
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, SRC, XDH 2.70981
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.59937
[MF] GO:0046983 protein dimerization activity ABCG2, ACHE, ADORA1, ADRB1, AOX1, AR, AXL, BCL2, EGFR, ERBB2, FLT3, HSP90AA1, HSP90AB1, PPARG, TYR, XDH 2.57199
[MF] GO:0099583 None GRM1, GRM5 2.41216
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.34521
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.34521
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.31307
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, KDR, NR3C1 2.31056
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.26759
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.25304
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17397
[MF] GO:0004971 None GRIA2, GRIA4 2.17397
[MF] GO:0005497 None AR, SHBG 2.17397
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.10409
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSP90AA1, IGF1R, KDR, MET, PIM1, SRC 2.02197


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.9337
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, GPER1, MMP9, ESR1, GRM1, EGFR, ESR2 9.44
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.5505
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.4872
Pathways in cancer_Homo sapiens_hsa05200 HSP90AA1, HSP90AB1, FLT3, MMP1, MMP2, MMP9, EGFR, IGF1R, AR, ERBB2, BCL2, PPARG, MET 7.0312
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, ADRB1, NR3C1, GRM1, GRIA4 6.7058
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.1162
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 6.6156
Prostate cancer_Homo sapiens_hsa05215 AR, HSP90AA1, HSP90AB1, ERBB2, BCL2, EGFR, IGF1R 6.0984
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 6.6743
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 5.9154
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.3145
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.0801
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, ADRB1, CACNA1C, PPARA, GRIA4 3.9439
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, TYR, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.8601
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 3.9281
MicroRNAs in cancer_Homo sapiens_hsa05206 ERBB2, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.8348
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 4.1429
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, PGR, CDC25B, IGF1R 3.5658
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ERBB2, ADRB1, CACNA1C, GRM1, EGFR 3.3501
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.5222
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, ADRB1, GRM1, EGFR 3.7713
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 HSP90AA1, HSP90AB1, KDR, BCL2, MET, EGFR, IGF1R 2.7342
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8601
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1, EGFR 2.8801
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.6059
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 3.1322
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.1232
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.1411
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.6568
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.4947
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, EGFR, IGF1R 2.2242
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, EGFR, IGF1R 2.4947
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 1.8505
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.2242
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, CACNA1C, GRIA4 2.0411
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1553
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0022
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9952
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.0865
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.034
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.6594
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 1.7934
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.712
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.0268
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.5724
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, EGFR, IGF1R 1.5005
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, CACNA1C 1.5699
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.4908
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.5045
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, CACNA1C, GRIA4 1.4496
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, EGFR, IGF1R 1.4219
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3421
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.3425
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.3421
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3151
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.3151
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2 1.2624
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 0.8925
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.261
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2853
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9329
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2976
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.813
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.285
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5955
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5615
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6533
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.309
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7878
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.6183
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7986
AMPK signaling pathway_Homo sapiens_hsa04152 PPARG, IGF1R 0.8601
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8925
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8925
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3398
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8925
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3586
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3586
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3623
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3568
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PPARG, IGF1R 1.0365
Osteoclast differentiation_Homo sapiens_hsa04380 PPARG 0.3694
Platelet activation_Homo sapiens_hsa04611 SRC 0.387
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3845
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3896
Axon guidance_Homo sapiens_hsa04360 MET 0.3793
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 1.1131
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0398
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.3896
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4135
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.0601
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0725
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4406
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4406
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4406
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4419
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4467
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4461
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.459
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4598
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4598
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1568
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4598
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4607
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4598
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4598
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4681
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4598
Peroxisome_Homo sapiens_hsa04146 XDH 0.466
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1 1.1617
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.3764
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.466
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4786
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3403
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4947
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.3421
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2752
Pancreatic cancer_Homo sapiens_hsa05212 ERBB2, EGFR 1.2685
Bile secretion_Homo sapiens_hsa04976 CA2, ABCG2 1.2209
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3151
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5085
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4947
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5272
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3183
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5294
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.3403
Shigellosis_Homo sapiens_hsa05131 SRC 0.5294
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3856
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5294
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5364
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4116
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15 1.3077
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4496
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5283
Malaria_Homo sapiens_hsa05144 MET 0.6167
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.712
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6183
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6183
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6183
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6077
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7224
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.6396
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6659
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.6799
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5923
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8921
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.7878
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7997
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7688
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7878
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8063
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7781
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7997
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1811
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0277
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3151


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)