TCM Prescription: Hu Po Huan Qing Pills



Prescription Description
Prescription IDTCMF4733
Pinyin NameHu Po Huan Qing Wan
Chinese Name琥珀还晴丸
English NameHu Po Huan Qing Pills
Function Description夜盲症
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH916 Succinus 琥珀 TCMH916
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH1698 Semen celosiae 青葙子 TCMH1698
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1933 Herba dendrobii 石斛 TCMH1933
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1811 Semen astragali complanati 沙苑子 TCMH1811
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH1294 Cornu saigae tataricae 羚羊角 TCMH1294
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 12.0741
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, FABP3, FUT7, GBA2, GLO1, NR1H4, PDE5A, PIM1, PPARA, TBXAS1, TYR, XDH 11.3113
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, NR1H4, PPARA, TBXAS1 11.2784
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.111
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4 10.6396
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOB, MET, NR1H4, POLA1, POLB, PPARA, SRC, THRA, THRB, TNKS, TNKS2, XDH 10.3654
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2566
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MAOB, MMP2, MMP9, NR1H4, POLB, PPARA, RORC, SRC, TYR 9.94168
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, NR1H4, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 9.90583
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, PHF8, TBXAS1, TYR, XDH 9.19862
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MMP2, NR1H4, POLB, PPARA, RORC, SRC, TYR 8.99244
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.99244
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, KDR, MAOB, MET, MMP2, MMP9, PHF8, PIM1, POLB, PPARA, RORC, SRC, THRA, THRB, TNKS2, TOP2A, TYR 8.07702
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 7.85931
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, DRD1, DRD2, GBA2, MAOB, NR1H4, TYR 7.59093
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, MAOB, NR1H4, RORC, SRC, TYR 7.57302
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, MAOB, RORC, SRC, TYR 7.54038
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HCAR2, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 7.54038
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HCAR2, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 7.50859
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NR1H4 7.3086
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 7.24583
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MMP2, MMP9, NR1H4, POLB, PPARA, RORC, SRC, TYR 7.24583
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 7.24583
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 7.21675
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MAOB, MMP9, SRC 7.02975
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MAOB, MMP2, NR1H4, PPARA, SRC 6.95632
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 6.85769
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, SRC, THRA, THRB 6.83558
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PIM1, PPARA, RORC, SRC, THRA, THRB 6.8099
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 6.69348
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.58778
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 6.45399
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, THRA, THRB, TNKS2, TYR 6.40897
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.1712
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MAOB, MMP9, PHF8, PIM1, POLB, PPARA, RORC, SRC, THRA, TYR 6.16004
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 6.07716
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, HCAR2, KDR, NR1H4, SRC, TNKS, TNKS2 6.0449
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, SRC, THRA, THRB 5.90734
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, MAOB, PPARA, SRC 5.83996
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, NR1H4, PPARA 5.83385
[BP] GO:0007200 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1 5.79477
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.75732
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PDE5A, PIM1, SRC, XDH 5.75732
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, FUT7, GBA2, MET, PPARA, TBXAS1 5.71117
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 5.7035
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.54388
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 5.39671
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.38457
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, NR1H4, PPARA, TBXAS1 5.1717
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, DRD2, KDR, MAOB, POLB, SRC 5.16849
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.14364
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 5.14364
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PPARA, PTPN1, SRC, THRA, TOP2A, XDH 5.14364
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 5.12561
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PTPN1, SRC, THRA, TOP2A, XDH 5.12561
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.12561
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.12561
[BP] GO:0007188 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2 5.11183
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 5.11183
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, SRC, THRA 5.03838
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 5.03284
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PHF8, POLB, PPARA, SRC, THRA, TYR 5.03284
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, DRD2 4.97009
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, DRD2, PDE5A, THRA, THRB 4.90243
[BP] GO:0018958 None AKR1B1, BCL2, DAO, DRD1, DRD2, MAOB, TYR 4.90122
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR1H4, RORC, SRC 4.87096
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 4.86508
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, NR1H4, PPARA, RORC, SRC, THRA 4.80651
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, TBXAS1 4.75774
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, DRD1, DRD2, MAOB 4.75378
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PIM1, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 4.7454
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR1H4, RORC, SRC 4.72991
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 4.63419
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, NR1H4, PIM1, PTPN1, SRC, THRA, TOP2A, XDH 4.63305
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, NR1H4, PPARA 4.60588
[BP] GO:0007187 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2 4.59792
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HSD11B2, KDR, MAOB, POLB, SRC 4.5586
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MMP12, MMP2, MMP9, NR1H4, POLA1, POLB, PPARA, PTPN1, RORC, SRC, THRA, TOP2A, TYR 4.49366
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GBA2, GLO1, NR1H4, PIM1, PPARA, TBXAS1, TYR 4.3947
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, FABP3, FABP4, FUT7, GBA2, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 4.32708
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, KDR, MET, PDE5A, PTPN1, SRC, XDH 4.32708
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 4.29085
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLB, PPARA, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.27263
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, KDR, MMP9, NR1H4, PDE5A, PTPN1, SRC, XDH 4.25811
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, KDR, MMP9, NR1H4, PDE5A, PTPN1, SRC, XDH 4.25811
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD2, ESR1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 4.24293
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 4.22896
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.21366
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 4.19585
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, MET, NR1H4, POLA1, POLB, SRC 4.16336
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTPN1, SRC, THRA, TNKS, TNKS2, XDH 4.13746
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3 4.1221
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESRRA, F3, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, NR1H4, PDE5A, PTPN1, SRC, TNKS, TNKS2, XDH 4.11439
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR1H4, POLA1, POLB, PTPN1, RORC, SRC, TOP2A 4.0663
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTPN1, SRC, THRA, TNKS, TNKS2, XDH 4.0486
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NR1H4, PDE5A, PIM1, POLB, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2 4.01267
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 3.97322
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, HCAR2, NR1H4, TNKS, TNKS2 3.91473
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, NR1H4, PDE5A, PTPN1, SRC, XDH 3.87643
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GBA2, GLO1, NR1H4, PIM1, PPARA, TBXAS1, TYR 3.87643
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, HCAR2, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PIM1, SRC, THRA, THRB, TNKS2, XDH 3.82894
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 3.8054
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GBA2, GLO1, NR1H4, PIM1, PPARA, TBXAS1, TYR 3.78314
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, POLA1, SRC, TYR 3.76614
[BP] GO:0006584 None AKR1B1, DAO, DRD1, DRD2, MAOB 3.69688
[BP] GO:0009712 None AKR1B1, DAO, DRD1, DRD2, MAOB 3.69688
[BP] GO:0007617 None APP, DRD1, THRA, THRB 3.6874
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CHRM5, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, NR1H4, PDE5A, PPARA, PTPN1, SRC, XDH 3.67074
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.6504
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, DRD1, DRD2, MAOB 3.64735
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MAOB, MMP9 3.64465
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, SRC, THRA, THRB, TOP2A 3.62664
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, CHRM5, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, NR1H4, PDE5A, PPARA, PTPN1, SRC, XDH 3.62561
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, DRD2, FLT3, KDR, PDE5A, PTPN1, SRC, XDH 3.41746
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, MMP12, NR1H4, PHF8, PPARA, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 3.39967
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.38619
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.38619
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C, DRD2 3.38056
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.38056
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.38056
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE5A, PIM1, POLB, PTPN1, SRC, TNKS, XDH 3.37427
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, DRD2, HCAR2, PDE5A, THRA, THRB 3.37307
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTPN1, SRC, TNKS 3.37173
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.36979
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA, THRA 3.34438
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, RORC, SRC 3.32934
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, SRC, TNKS, TNKS2 3.32934
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.32934
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.32934
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 3.28154
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PPARA, PTPN1, SRC 3.28032
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ADRA2C, ALOX15, APP, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, HCAR2, MAOB, MMP12, MMP9, NR1H4, PPARA, PTPN1, SRC, THRA 3.25458
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, MMP12, NR1H4, PHF8, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 3.24537
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.23339
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, PPARA, RORC, SRC, TOP2A 3.22306
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, NR1H4, RORC, SRC 3.15067
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, POLB, PPARA, SRC 3.14565
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, DRD1, SRC 3.14565
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.14565
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PTPN1, SRC 3.12557
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 3.1221
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, NR1H4, PPARA, SRC, TYR 3.12176
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4, PHF8 3.11995
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, ESRRB, FLT3, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 3.10396
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE5A, PIM1, POLB, PTPN1, SRC, TNKS, XDH 3.0993
[BP] GO:0042417 None DAO, DRD1, DRD2, MAOB 3.09896
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 3.09018
[BP] GO:0006937 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, PDE5A 3.06532
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PPARA, PTPN1, SRC, XDH 3.06117
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, MMP12, NR1H4, PHF8, PPARA, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 3.06117
[BP] GO:0019098 None APP, DRD1, THRA, THRB 3.05398
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C, APP 3.05398
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, HSD11B2, MMP2, POLB, PPARA, SRC, THRA, TYR 3.05217
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.02848
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.02848
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, MMP12, NR1H4, PHF8, PPARA, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A 3.00244
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.97813
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, APP, AXL, BCL2, CA2, CHRM3, CYP1B1, DRD2, ESRRB, F3, HCAR2, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PIM1, SRC 2.96827
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, DAO, MAOB 2.91454
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9, THRA 2.91454
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, RORC 2.91454
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 2.91218
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 2.89425
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, NR1H4, PDE5A, PPARA, PTPN1, SRC, THRA, TNKS, TNKS2, XDH 2.87028
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, APP, CA2, CHRM1, DRD2, HCAR2, MMP12, NR1H4, PTPN1, SRC, THRA 2.86927
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 2.82239
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DRD1, DRD2, FABP3, FLT3, HSD11B2, IGF1R, MMP2, NR1H4, PPARA, SRC, TYR 2.8218
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.82133
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AOX1, APEX1, APP, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, NR1H4, PDE5A, PHF8, POLA1, POLB, PPARA, RORC, THRA, THRB, TOP2A, TYR, XDH 2.7911
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2 2.78858
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, ALOX15, APP, DRD2, FLT3, IGF1R, KDR, PDE5A, PTPN1, SRC, XDH 2.78699
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, NR1H4, SRC 2.77832
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD2, FLT3, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.77698
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.75965
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 2.75965
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, DRD1 2.74285
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, DRD1 2.74285
[BP] GO:0008050 None THRA, THRB 2.74285
[BP] GO:0009115 None AOX1, XDH 2.74285
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.74285
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, APP, PTPN1 2.74272
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.73364
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, MET, MMP2, MMP9, RORC, SRC, THRA, THRB, TOP2A 2.71734
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, DRD2, HCAR2, MMP12, NR1H4, SRC 2.71285
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 2.70917
[BP] GO:0051952 None ADORA1, ADRA2A, ADRA2C, DRD1, DRD2 2.6953
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 2.69223
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.67834
[BP] GO:0033604 None ADRA2A, ADRA2C, DRD2 2.67834
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX15, BCL2, CDK6, CYP19A1, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, SRC, XDH 2.67764
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, NR1H4, PIM1, PTPN1, SRC 2.67678
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 2.66328
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC 2.66037
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.63619
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 2.63619
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.63284
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, DRD1 2.63239
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, DRD1 2.61728
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.59746
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PTPN1, SRC, XDH 2.5836
[BP] GO:0003008 None ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, BCL2, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, DRD2, HSD11B2, PDE5A, SRC, THRA, THRB, TYR 2.55959
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DAO, MAOB, PDE5A, XDH 2.55738
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.55678
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.5316
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM3, DRD1, SRC 2.5316
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.5316
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, KDR, SRC 2.52484
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, DRD2, MAOB, MMP9 2.50064
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC 2.50064
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, PTPN1 2.50064
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.48905
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, FABP3, FABP4, FUT7, GBA2, MAOB, PDE5A, XDH 2.46064
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, BCL2, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, XDH 2.45533
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTPN1, SRC, THRA, TNKS, TNKS2, XDH 2.45121
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.45026
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.45026
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, BCL2, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, NR1H4, PTPN1, SRC, XDH 2.4462
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APEX1, APP, AURKB, BCL2, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, XDH 2.39421
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, MAOB, SRC 2.37929
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.37802
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, XDH 2.3639
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.3639
[BP] GO:0046110 None AOX1, XDH 2.3639
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.3639
[BP] GO:0006808 regulation of nitrogen utilization BCL2, NR1H4 2.3639
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.34528
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.3136
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CDK6, CYP19A1, DRD2, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, NR1H4, PPARA, PTPN1, SRC, XDH 2.3132
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, MAOB, SRC 2.31191
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, FUT7, GBA2, GLO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 2.31191
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.30069
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, ADRA2C, APP, BCL2, DRD2, MAOB, MMP9, NR1H4, THRA 2.29699
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, APP, BCL2, CHRM1, DRD2, HCAR2, MMP12, NR1H4, PTPN1, SRC, THRA 2.29699
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, MET, NR1H4 2.29699
[BP] GO:0090257 None ADORA1, ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, PDE5A 2.29699
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.26656
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, APP, FLT3, PTPN1, SRC 2.2642
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.25757
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.25076
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, BCL2, CA2, CA7, CHRM1, DRD1, DRD2, MAOB, MMP9 2.25076
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, DAO, TYR 2.22589
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 2.22589
[BP] GO:0008016 None ADORA1, ADORA3, CHRM2, DRD2, PDE5A, THRA, THRB 2.2043
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.20361
[BP] GO:0071880 None ADRA2A, ADRA2C, DRD2 2.19949
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 2.19923
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, IGF1R, MET, MMP9, NR1H4, PTPN1, SRC, XDH 2.17023
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, NR1H4, PPARA 2.11386
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.11386
[BP] GO:0035625 None ADRA2A, ADRA2C 2.11386
[BP] GO:0032811 None ADRA2A, ADRA2C 2.11386
[BP] GO:0070213 None TNKS, TNKS2 2.11386
[BP] GO:0006145 None AOX1, XDH 2.11386
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.11386
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, ESR1, ESRRA, HCAR2, MMP12, MMP2, NR1H4, PDE5A, PTPN1, SRC 2.11386
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, PTPN1, SRC 2.09435
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.09435
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.09435
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DAO, FABP3, FABP4, GBA2, MAOB, PDE5A, SRC, XDH 2.09043
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, NR1H4, SRC, TNKS, TOP2A 2.06463
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.05087
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.05014
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.04151
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HCAR2, MMP12, NR1H4, SRC 2.04008
[BP] GO:0045893 None APP, DRD2, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, PHF8, PPARA, RORC, SRC, THRA, THRB, TNKS, TOP2A 2.03981
[BP] GO:1903508 None APP, DRD2, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, PHF8, PPARA, RORC, SRC, THRA, THRB, TNKS, TOP2A 2.03981
[BP] GO:1902680 None APP, DRD2, ESR1, ESR2, ESRRA, ESRRB, MET, MMP12, NR1H4, PHF8, PPARA, RORC, SRC, THRA, THRB, TNKS, TOP2A 2.03833
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.03833
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.03833
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.03306
[BP] GO:0019229 None ADRA2A, ADRA2C, CHRM1, CHRM3 2.03306
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, IGF1R, PDE5A, PTPN1, SRC, TNKS 2.02202
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.00881
[BP] GO:0071875 None ADRA2A, ADRA2C, DRD2 2.00002
[CC] GO:0043679 None ADRA2C, CHRM1, CHRM2, CHRM3, DRD2 3.24537
[CC] GO:0098793 None ADORA1, ADRA2C, APP, CHRM1, CHRM2, CHRM3, DRD2 3.00681
[CC] GO:0044306 None ADRA2C, CHRM1, CHRM2, CHRM3, DRD2 2.82454
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MAOB, MET, MMP2, PHF8, PIM1, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TYR 2.55374
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, TBXAS1 2.4351
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOB, MMP2, MMP9, PDE5A, PIM1, POLA1, PTPN1, SRC, TBXAS1, THRA, TNKS, TNKS2, TOP2A, TYR, XDH 2.42782
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, TBXAS1 2.39724
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, IGF1R, KDR, MET 2.29988
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, PHF8, PIM1, PPARA, PTPN1, RORC, TBXAS1, THRA, THRB, TNKS, TYR, XDH 23.747
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.2426
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 14.8223
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, F3, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PHF8, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 14.0615
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, TBXAS1, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 11.9705
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 11.7519
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, PHF8, PPARA, PTPN1, RORC, THRA, THRB, TNKS 11.6903
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOB, PHF8, TBXAS1, TYR, XDH 10.9122
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2194
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, TBXAS1, THRA, THRB, TNKS, TNKS2, TOP2A, TYR, XDH 9.88276
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PHF8, TBXAS1, XDH 9.52751
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 9.12361
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 9.12361
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 8.86018
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR1H4, PPARA, RORC, THRA, THRB 8.42238
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.90422
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, PPARA, RORC, THRA, THRB 7.14983
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR1H4, RORC 7.09302
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, HSD11B2, HSD17B1, MAOB, POLA1, SRC, TBXAS1, XDH 6.79533
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TBXAS1, TYR 6.76662
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.5858
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, PPARA, RORC, THRA, THRB 6.54146
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PHF8, TBXAS1, TYR 6.1712
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.1712
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, PPARA, RORC, THRA, THRB 6.1712
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC, TBXAS1 5.75671
[MF] GO:0008227 None ADRA2A, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM5, DRD2 5.73104
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.54922
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, SRC, TBXAS1 5.50529
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, PPARA, RORC, THRA, THRB 5.39671
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 4.97009
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR1H4, PPARA, RORC 4.28065
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 4.24023
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.16336
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.79304
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.77627
[MF] GO:1901338 None ADRA2A, ADRA2C, DRD1, DRD2 3.61272
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, THRA, THRB 3.50768
[MF] GO:0004887 None NR1H4, THRA, THRB 3.38619
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5, PDE5A 3.36979
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.14565
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, THRA 3.11269
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.09441
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.05398
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.04474
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.02848
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2 3.00847
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.00847
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC, THRA 2.96827
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ADRA2C, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DAO, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MAOB, MET, MMP12, NR1H4, PDE5A, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TBXAS1, THRA, THRB, TOP2A, XDH 2.90425
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.74285
[MF] GO:0003845 None HSD11B1, HSD11B2 2.74285
[MF] GO:0008389 None CYP2A13, CYP2A6 2.74285
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.67477
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.63284
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, PDE5A, POLA1, PTPN1 2.62294
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, HCAR2, IGF1R, KDR, MET 2.5674
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, HCAR2, IGF1R, KDR, MET 2.5674
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, PDE5A, PTPN1 2.5316
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.46388
[MF] GO:0004935 None ADRA2A, ADRA2C, DRD2 2.45026
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.3639
[MF] GO:0004938 None ADRA2A, ADRA2C 2.3639
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, AOX1, APP, BCL2, CSNK2A1, DRD2, ESR1, ESR2, FLT3, IGF1R, KDR, MAOB, MET, MMP9, TOP2A, TYR, XDH 2.24879
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.11386
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.11386
[MF] GO:0032795 None ADORA1, ADRA2A 2.11386
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.11386
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.00881


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.446
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.6576
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOB, ALOX15, AKR1B1, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, POLA1, CYP2A6, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 7.286
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.286
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.3479
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, THRB, CHRM1, THRA, ADORA3, CHRM5, ADORA1, DRD1, ADRA2C, DRD2, ADRA2A 7.286
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.286
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 4.8952
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 3.9201
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.572
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.9201
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, DRD1, DRD2, PPARA 3.5894
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP1A2, AOX1, CYP3A4 3.83
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.7158
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.2214
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.6763
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.572
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.6796
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1 2.9119
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, BCL2, MET, IGF1R 2.3793
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A, ADRA2C, ADRA2A 2.3343
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.755
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.2624
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, DRD1 2.2378
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.0746
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOB, ALOX5, ALOX15 2.1579
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.0054
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 THRB, THRA, SRC, ESR1 2.0887
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 1.9918
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.8359
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.8359
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 2.5278
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8359
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.7122
Cocaine addiction_Homo sapiens_hsa05030 MAOB, DRD1, DRD2 2.1978
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.2469
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5666
Bile secretion_Homo sapiens_hsa04976 CA2, NR1H4, CYP3A4 1.8359
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 1.6148
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, DRD1, DRD2 1.2453
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.141
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.3192
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.0844
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE5A, XDH 1.0096
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 0.9996
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 0.9076
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.8428
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.141
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.141
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.9076
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9076
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.0758
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1111
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.0096
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8693
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, DRD1 1.0667
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9076
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.0667
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7328
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9197
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8435
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.751
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8179
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9821
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.8972
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.1717
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.8791
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7701
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1717
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7701
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 0.9404
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7033
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.0622
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1299
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7496
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6996
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6996
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5113
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.564
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.6996
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.25
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2733
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2499
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2733
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO, MAOB 1.2221
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.2875
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3016
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.2983
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3128
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3128
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3114
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.323
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.323
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3363
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3363
Axon guidance_Homo sapiens_hsa04360 MET 0.3316
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3407
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3666
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3894
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3893
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3792
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.3931
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4009
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4007
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4134
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.4169
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4129
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4134
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4134
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4134
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4134
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4134
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4566
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4312
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8952
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4683
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4827
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4699
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.4827
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4827
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4827
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4911
Shigellosis_Homo sapiens_hsa05131 SRC 0.4827
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.4827
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4827
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO, MAOB 1.3787
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5702
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5113
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5411
Malaria_Homo sapiens_hsa05144 MET 0.5525
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4571
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5602
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5364
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5563
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.5204
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5602
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6164
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7755
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6107
DNA replication_Homo sapiens_hsa03030 POLA1 0.6438
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6996
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7031
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7328
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6996
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7224
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.7503
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.8499
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8428
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9076
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.141


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)