TCM Prescription: Huo Xue Tiao Jing Pills



Prescription Description
Prescription IDTCMF4401
Pinyin NameHuo Xue Tiao Jing Wan
Chinese Name活血调经丸
English NameHuo Xue Tiao Jing Pills
Function Description月经失调
IndicationsIrregular menstruation
Disease ICD-11 Category GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH541 Colla corii asini 阿胶 TCMH541
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2188 Trogopterus xanthipes 五灵脂 TCMH2188
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2044 Caesalpinia sappan 苏木 TCMH2044 ITSAJ4578-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.8243
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9623
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.684
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.68
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MET, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.3083
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.09172
[BP] GO:0042221 response to chemical ABCB1, ADRA1A, AKR1B1, ALOX15, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, POLB, PPARA, SMAD3, SRC, TEK, TYR 9.09172
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, HSPA1A, HTR2B, PIM1, PPARA, TBXAS1, TYR, XDH 9.00704
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.96612
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 8.87089
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALOX15, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR5A, IGF1R, INSR, KDR, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TYR 8.87046
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F2, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.84961
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F2, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 8.84724
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, SRC, TEK, XDH 8.49448
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD17B2, HTR5A, IGF1R, INSR, MMP2, MMP9, POLB, PPARA, SRC, TEK, TYR 8.19453
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CYP1B1, DRD2, EGFR, F10, F2, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, SRC, TEK, XDH 8.15715
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 8.1504
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 7.98673
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 7.91203
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 7.90858
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 7.66381
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F10, F2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.40081
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.24875
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, F2, HCAR2, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2 7.19866
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, INSR, MET, POLA1, POLB, SMAD3, SRC 7.03053
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, POLA1, POLB, PPARA, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 7.03053
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 6.95663
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.82186
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 6.7957
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 6.74048
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.66538
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.66538
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.55408
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.48853
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1 6.45558
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 6.45558
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, KDR, SRC 6.40393
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA3, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TYR 6.40393
[BP] GO:0042493 response to drug ABCB1, ADRA1A, AKR1B1, AXL, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KDR, POLB, SRC 6.35627
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.35297
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CBR1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TNKS2, TYR 6.34879
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.22988
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F2, F3, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK 6.18046
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, F2, F3, FABP4, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TNKS2, TYR 6.08298
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, F2, HCAR2, TNKS, TNKS2 6.08006
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, HTR5A, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 6.00522
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 5.97031
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, TBXAS1 5.94484
[BP] GO:0007187 None ADORA1, ADRA1A, CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 5.84875
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, HTR5A, INSR, KDR, MMP9, PIM1, POLB, PPARA, PTPRS, SIGMAR1, SMAD3, SRC, TEK, TYR 5.79135
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, HTR5A, SRC, TEK, TYR 5.67618
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, AXL, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, SIGMAR1, SMAD3, SRC, TEK, TNKS, TNKS2 5.66873
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.60175
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.60175
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.60175
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, FABP4, GPR35, HTR2A, HTR2B, INSR, MET, SMAD3 5.5641
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.48358
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HTR5A, INSR, PPARA, SRC, TEK 5.47052
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC, TEK 5.44102
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA, TBXAS1 5.44102
[BP] GO:0007188 None ADORA1, ADRA1A, CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.34495
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.34104
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.29519
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 5.2534
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A 5.2316
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.23134
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.20739
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, HTR2A, HTR2B, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TYR 5.20501
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPRS, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 5.18432
[BP] GO:0007193 None ADORA1, CHRM2, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.1763
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 5.15876
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, F2, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, SRC, TEK 5.09305
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A 5.06993
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SIGMAR1, SMAD3, SRC, TEK, XDH 5.06461
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, SIGMAR1, SMAD3, SRC, TEK, XDH 5.01277
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC, TEK 5.01277
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.01277
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.00602
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.99702
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.99702
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, CHRM2, DRD1, DRD2, DRD3, ESR1, F2, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, SIGMAR1, SRC 4.92679
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, EGFR, F2, PPARA, SMAD3 4.91532
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SRC 4.90049
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, ADRA1A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, XDH 4.88083
[BP] GO:0007200 None ADRA1A, CHRM2, DRD1, DRD2, ESR1, HTR2A, HTR2B 4.83596
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.81714
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD17B1, HSD17B2 4.804
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.80352
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 4.80174
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.75069
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, GPR35, HTR2A, HTR2B, SMAD3 4.69232
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, DRD1, DRD2, EGFR, ESRRB, F2, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 4.67303
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, DRD1, DRD2, EGFR, ESRRB, F2, FABP3, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 4.67303
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.67303
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, DRD2, EGFR, HTR2A, HTR2B, KDR, SRC, TEK 4.61636
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ALOX15, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPRS, SMAD3, SRC, TEK, XDH 4.60327
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F2, F3, FABP4, KDR, MET, PPARA, PTPRS, SMAD3, TEK 4.6005
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.57321
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.56253
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, SIGMAR1, SMAD3, SRC, TEK, XDH 4.5199
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.47096
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KDR, SRC, TEK, XDH 4.47096
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, SRC, TEK 4.43923
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.40869
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.40711
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, AXL, CA2, CHRM2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F2, F3, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, MMP9, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 4.40164
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, F2, PPARA, PTPRS, SMAD3, TEK 4.37853
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.37259
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP9, PTPRS, SMAD3, SRC, XDH 4.37044
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.37044
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, SRC, TEK, XDH 4.36243
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, AURKB, AXL, CA3, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPRS, SRC, TEK, TNKS, XDH 4.36243
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP9, PTPRS, SMAD3, SRC, XDH 4.36243
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, HTR5A, SRC, TYR 4.34731
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.32475
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.31761
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.31761
[BP] GO:0006811 None ABCB1, ADRA1A, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA 4.29934
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.29934
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.26222
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 4.26001
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, F2, GPR35, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MMP9, PPARA, SMAD3, SRC 4.22455
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, AURKB, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, SMAD3, SRC, TEK, TNKS, XDH 4.22455
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ALOX15, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.21977
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 4.207
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.19229
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F2, F3, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPRS, SMAD3, SRC, TEK, XDH 4.1644
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A 4.14073
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HTR2A 4.14073
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIM1, POLA1, SRC, TEK, TYR 4.12411
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 4.12411
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 4.0973
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.08368
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.06435
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, AURKB, AXL, CA3, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPRS, SRC, TEK, TNKS, XDH 4.05106
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, TBXAS1 4.01387
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, EGFR 4.01118
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ALOX15, DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PPARA, SRC, TEK, XDH 3.99301
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, TYR 3.93866
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.93845
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CA3, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, POLB, SRC 3.92094
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F2, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP9, PIM1, SMAD3, SRC, TEK 3.86718
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.86718
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR1A, INSR, SMAD3 3.81637
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.80304
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 3.76956
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, SRC, TNKS 3.76616
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, HCAR2, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.75949
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.7456
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.7456
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 3.71753
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ALOX15, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.70125
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.69811
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ALOX15, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.68827
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.66913
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ALOX15, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.66207
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 3.61099
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, ADRA1A, AURKB, DRD2, EGFR, ESR1, ESR2, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, SMAD3, SRC, TEK, TNKS, XDH 3.59825
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, F2, HCAR2, HTR2B, INSR, SMAD3, SRC 3.57946
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2 3.56135
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, SMAD3, SRC, TEK 3.54032
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.51061
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.51061
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, HTR7, PPARA, SRC 3.48139
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 3.47096
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ALOX15, DRD2, EGFR, ESRRB, F2, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, SRC, TEK, XDH 3.44819
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.4468
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS 3.41812
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH 3.40924
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, POLB, PPARA, SMAD3, SRC, TEK 3.40924
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.40112
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.40112
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, PPARA, SMAD3, SRC, TNKS, TNKS2 3.37629
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLB, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.37179
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.37179
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.37179
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.37179
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.37179
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 3.35694
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 3.34494
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.32393
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, HTR2A 3.32393
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, F2, FABP4, HSPA1A, MMP2, PPARA, PTPRS, SMAD3, SRC, TEK 3.3073
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 3.26228
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.25646
[BP] GO:0055074 calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 3.24307
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.22961
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.22707
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, EGFR, HTR2B, HTR5A, KDR 3.20265
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 3.20213
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.1684
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, F2, PPARA, SMAD3, TEK 3.14102
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SRC, TEK 3.14102
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.12243
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.12243
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.12243
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.12231
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, F2, PPARA, SMAD3, TEK 3.08784
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, DRD2, EGFR, F2, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, SRC, TEK, XDH 3.08784
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.08784
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, F2, GPR35, HTR1A, HTR2A, MMP9 3.08784
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.07531
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TYR 3.07531
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, SRC 3.06079
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, F2, GPR35, HTR2A, HTR2B 3.05977
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC, TEK 3.05775
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, CSNK2A1, DRD2, EGFR, ESR1, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 3.05113
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.04015
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ALOX15, DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, SRC, TEK, XDH 3.03458
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 3.03458
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.03458
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC 3.03053
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, SRC, XDH 3.03053
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, CHRM2, DRD2, DRD3, EGFR, GPR35, HCAR2, HTR2A, SMAD3 3.01727
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.01727
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, AOX1, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 3.01174
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.0047
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, SRC 2.95599
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.94603
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, TBXAS1, TYR 2.94253
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, POLB, SRC, TEK 2.87627
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, DRD2, EGFR, ESR1, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, SMAD3, SRC, TEK, XDH 2.86334
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 2.86334
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 2.86334
[BP] GO:0009115 None AOX1, XDH 2.86334
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, AOX1, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 2.85202
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.84751
[BP] GO:0055065 metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 2.84751
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.83966
[BP] GO:0040008 regulation of growth CSNK2A1, DRD2, DRD3, EGFR, ESR2, F2, HSPA1A, INSR, PIM1, PTPRS, SMAD3, TNKS2 2.83392
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 2.83392
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.81817
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.81817
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.81817
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, SRC, TEK, TNKS 2.79294
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, AURKB, DRD2, EGFR, ESR1, F2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, SMAD3, SRC, TEK, TNKS, XDH 2.76424
[BP] GO:0016310 phosphorylation AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 2.75351
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP9, SRC, TEK 2.75277
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.73072
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.73072
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.73072
[BP] GO:0019725 cellular homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, POLA1, SMAD3 2.73072
[BP] GO:0090066 None ADORA1, ADRA1A, ALOX15, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 2.72518
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK 2.72372
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.67548
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC, TEK 2.67546
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, GPR35, HTR2A, MMP9 2.67355
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.66995
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, DRD2, EGFR, F2, FLT3, HTR2A, HTR2B, INSR, SRC, TEK, TNKS 2.66489
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.64953
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.64699
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.64699
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.63427
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, SRC 2.62717
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.58447
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, F2, GPR35, HTR2A, HTR2B, SMAD3 2.58287
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, SMAD3, TEK 2.57859
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.57717
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.57717
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.57717
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.57717
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F2, FABP3, HSPA1A, HTR2A, HTR2B, MMP9, PPARA, SIGMAR1, SRC, TNKS, TNKS2, XDH 2.57717
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, SMAD3, XDH 2.57181
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, PPARA, SMAD3 2.56605
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, INSR, MET, PPARA, SMAD3, SRC, TNKS, TNKS2 2.56258
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.55527
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, TBXAS1, TYR 2.55194
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, SMAD3, SRC 2.52232
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.50683
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, TBXAS1, TYR 2.47238
[BP] GO:0046110 None AOX1, XDH 2.46711
[BP] GO:0060160 None DRD2, DRD3 2.46711
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46711
[BP] GO:0043549 regulation of kinase activity ADORA1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, SRC, TEK 2.43793
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.43793
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.43793
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.43632
[BP] GO:1900542 None DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, PPARA 2.41085
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9 2.40493
[BP] GO:0009056 catabolic process ACHE, ADORA1, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, SRC, XDH 2.39983
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, POLA1, POLB, SMAD3, SRC 2.383
[BP] GO:0007267 None ADORA1, ADRA1A, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, TEK 2.383
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.383
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, EGFR, F10, F2, FABP3, HSPA1A, HTR2A, HTR2B, MMP9, PPARA, SIGMAR1, SRC, TNKS, XDH 2.383
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.37834
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.37834
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.3688
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.3688
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, EGFR, F2, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.36327
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F2, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, SMAD3, SRC, TEK 2.35127
[BP] GO:0006140 None DRD1, DRD2, DRD3, ESRRB, HTR2A, INSR, PPARA 2.34769
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.34097
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, F2, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, POLA1, SMAD3, SRC 2.33118
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.33054
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.32238
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.31731
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.31731
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, F2, INSR, SMAD3, XDH 2.3091
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, PPARA, SMAD3, SRC, TNKS, TNKS2 2.29099
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.29062
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, SMAD3, SRC, TEK, XDH 2.27401
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.27281
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.26963
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.2685
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.24979
[BP] GO:0051128 regulation of cellular component organization ALOX15, AURKB, AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 2.24924
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.2389
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F10, F2, FABP3, HSPA1A, HTR2A, HTR2B, MMP9, PPARA, SIGMAR1, SRC, TNKS, XDH 2.23185
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, POLA1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.22987
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CA3, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.22987
[BP] GO:0051098 regulation of binding AURKB, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TNKS 2.22987
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, SRC 2.22595
[BP] GO:0070213 None TNKS, TNKS2 2.22595
[BP] GO:0006145 None AOX1, XDH 2.22595
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.22595
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22595
[BP] GO:0033674 positive regulation of kinase activity ADORA1, DRD2, EGFR, F2, FLT3, HTR2A, HTR2B, INSR, SRC, TEK 2.22595
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.22542
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.22542
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.19593
[BP] GO:0051282 None DRD1, DRD2, F2, HTR2A, HTR2B 2.18019
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, SMAD3 2.17295
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.17265
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.17265
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.17265
[BP] GO:0001503 ossification ALOX15, EGFR, MMP2, MMP9, TEK 2.16871
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 2.16871
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PTPRS, SMAD3, SRC, XDH 2.16312
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, HTR2B, MET, PPARA, SMAD3 2.16152
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A 2.16152
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, SRC 2.15348
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.15348
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.15344
[BP] GO:0051894 None KDR, SMAD3, TEK 2.12676
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.12676
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR1A, HTR2A, HTR2B, SRC 2.1215
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, SMAD3, SRC, TNKS, TNKS2, XDH 2.10691
[BP] GO:0050890 None ADORA1, DRD1, DRD2, DRD3, EGFR, HTR2A, INSR 2.08376
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ALOX15, DRD2, EGFR, F2, FLT3, HTR2A, HTR2B, INSR, KDR, MMP9, SRC, TEK, XDH 2.08376
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.08376
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.08376
[BP] GO:0050927 None F3, KDR, SMAD3 2.08309
[BP] GO:0050793 regulation of developmental process AXL, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F2, F3, HTR2A, INSR, KDR, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 2.0589
[BP] GO:0023052 None ADORA1, ADRA1A, CHRM2, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, TEK 2.04949
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, INSR, KDR, MET, PPARA, SMAD3, SRC, TNKS, TNKS2 2.04949
[BP] GO:0021853 None DRD1, DRD2 2.04949
[BP] GO:0010641 None F3, SRC 2.04949
[BP] GO:0090325 None DRD2, DRD3 2.04949
[BP] GO:0007598 None F10, F3 2.04949
[BP] GO:1904936 None DRD1, DRD2 2.04949
[BP] GO:0042321 None ADORA1, DRD2 2.04949
[BP] GO:0010513 None HTR2A, HTR2B 2.04949
[BP] GO:0045787 positive regulation of cell cycle AURKB, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 2.04949
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, TEK 2.04949
[BP] GO:0050926 None F3, KDR, SMAD3 2.04949
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.04949
[BP] GO:1903393 None KDR, SMAD3, TEK 2.04949
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.04949
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F2, F3, FABP4, KDR, MET, SMAD3 2.03871
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A 2.03676
[BP] GO:0006110 None ESRRB, HTR2A, INSR, PPARA 2.0298
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.0298
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ALOX15, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIM1, POLA1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.02539
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 2.02539
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.02539
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.01814
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 2.01814
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.01145
[BP] GO:0045745 None DRD2, DRD3, F2 2.01145
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CA4, CHRM2, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, TEK 7.08767
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ADRA1A, ALOX15, AXL, CA2, CA4, CA9, CHRM2, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F2, F3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, SRC, TEK 6.59315
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CHRM2, DRD1, DRD2, DRD3, FLT3, GPR35, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, TEK 5.55441
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F2, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPRS, SMAD3, SRC, TEK 4.86481
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPRS, SIGMAR1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR 4.31761
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, SRC, TBXAS1, TEK, TYR 3.90147
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, ADRA1A, CA2, CA4, CA9, CHRM2, DRD1, DRD2, EGFR, HTR2A, INSR, MET, SIGMAR1, SRC, TEK 3.5036
[CC] GO:0031233 None CA4, F10, F3 2.32238
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR2A, HTR5A, INSR, KDR, MMP2, MMP9, PIM1, POLA1, PTPRS, SIGMAR1, SMAD3, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 2.30493
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.12644
[CC] GO:0031224 None ABCB1, ACHE, ADORA1, ADORA3, ADRA1A, AXL, CA12, CA14, CA4, CA9, CHRM2, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HCAR2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTPRS, SIGMAR1, TBXAS1, TEK, TYR 2.08477
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.9293
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 17.8738
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, SMAD3, TBXAS1, TNKS, TYR, XDH 17.0705
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 11.9459
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8903
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 11.334
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, TBXAS1, TNKS, TNKS2, TYR, XDH 11.1988
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, F2, F3, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PTPRS, SRC, TBXAS1, TEK, TNKS, TNKS2, TUBB3, TYR, XDH 10.5592
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 10.0392
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, SMAD3, TEK 9.75053
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, SIGMAR1, TEK 9.72708
[MF] GO:0008227 None ADRA1A, CHRM2, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 8.72273
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, XDH 8.53836
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SIGMAR1, SRC, TEK 8.31554
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.09572
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 7.93712
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.88362
[MF] GO:0030594 None CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.72869
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 7.72869
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 7.72869
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, SMAD3, TNKS 7.20044
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.03053
[MF] GO:0099528 None CHRM2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.02431
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR 6.97269
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.74048
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.68375
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.68375
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.66538
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.66538
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.34338
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F2, MMP1, MMP2, MMP9, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, TBXAS1, TNKS, TNKS2, TYR, XDH 6.18208
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, TBXAS1 6.00522
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC, TBXAS1 5.74486
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.65969
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TBXAS1, TYR 5.36486
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.15935
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.88098
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.83596
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, POLA1, SRC, TBXAS1, XDH 4.7145
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.36243
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CHRM2, DRD1, DRD2, DRD3, GPR35, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 4.08656
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.66913
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.66913
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.44819
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.32393
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, HSD17B1, PPARA 3.31971
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.25646
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, SMAD3, SRC 2.90483
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.90483
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.86334
[MF] GO:0008389 None CYP2A13, CYP2A6 2.86334
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.81817
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 2.81144
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, CBR1, HSD17B1, HSD17B2, XDH 2.74638
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.73648
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, PPARA, SMAD3, SRC 2.695
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.66995
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 2.64953
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, AURKB, AXL, CSNK2A1, EGFR, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TUBB3, XDH 2.56916
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, PPARA, SMAD3, SRC, TBXAS1, TEK, TUBB3, XDH 2.56521
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.40234
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.32238
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.2528
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22595
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, TUBB3, XDH 2.08376
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04949
[MF] GO:0043559 insulin binding IGF1R, INSR 2.04949
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F2, F3, MMP1, MMP2, MMP9 2.01145


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.2997
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GPR35, HTR2B, HTR1A, HTR2A, F2, HTR5A, ADRA1A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 10.5268
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.8784
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, ALOX15, HTR2B, HTR1A, HTR2A, HTR5A 7.5123
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, EGFR 5.9431
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.264
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.264
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, HTR2B, HTR2A, DRD1, DRD2, EGFR 5.8614
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.6038
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.6459
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.7326
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 4.7673
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.6354
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0655
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.9024
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP19A1, POLA1, CYP2A6, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH 3.5119
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.4887
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.1506
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 2.8719
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7203
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, TEK, MET, EGFR, IGF1R 2.5363
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1 3.0562
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.9965
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1, F3 2.3535
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1 2.9333
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9333
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, MMP9, MET, EGFR 2.1412
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.3373
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.1356
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 1.9859
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.1153
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, ADRA1A 1.7286
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9755
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.9318
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.8851
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8798
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9259
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6467
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6461
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.5815
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, F2, EGFR 1.4177
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2, F3 1.7889
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, ADRA1A, IGF1R 1.3336
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.3061
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.1908
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.2138
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.1812
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.7373
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE 0.7655
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 0.9
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.7726
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9104
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8784
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8965
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.739
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7326
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.739
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.739
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8983
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.7373
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.6861
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.111
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9884
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.6821
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6755
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.1063
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1543
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6755
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6755
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1853
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.6735
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6602
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.0555
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6509
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6509
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.5874
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.585
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.537
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.537
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2695
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2876
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2779
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2693
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2801
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.4459
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3132
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3132
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.3197
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.3367
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3455
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.2835
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.3649
Axon guidance_Homo sapiens_hsa04360 MET 0.3601
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3649
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3697
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3962
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.417
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4093
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4162
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4162
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4162
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.409
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4214
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.421
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4256
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3178
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4379
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4459
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4379
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4379
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.445
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4379
Peroxisome_Homo sapiens_hsa04146 XDH 0.4459
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4751
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4737
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4626
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.487
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5017
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.4998
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5036
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5184
Shigellosis_Homo sapiens_hsa05131 SRC 0.5036
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5036
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5099
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.521
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.545
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.537
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.537
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.537
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5176
Malaria_Homo sapiens_hsa05144 MET 0.564
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5678
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5678
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.6467
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5678
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.585
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6234
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6509
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8016
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.6861
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.6755
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6724
Base excision repair_Homo sapiens_hsa03410 POLB 0.6602
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.6645
DNA replication_Homo sapiens_hsa03030 POLA1 0.6509
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6755
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.6509
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6861
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6861
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0655
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1748


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)