TCM Prescription: Ling Zhi Gui Yuan Wine



Prescription Description
Prescription IDTCMF4290
Pinyin NameLing Zhi Gui Yuan Jiu
Chinese Name灵芝桂圆酒
English NameLing Zhi Gui Yuan Wine
Function Description血劳, 早衰症
IndicationsAnemia
Disease ICD-11 Category MB21.1 [Amnesia, 健忘症 ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1299 Ganoderma lucidum 灵芝 TCMH1299 MGEN736-15
TCMH1329 Arillus longan 龙眼肉 TCMH1329
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH388 Ziziphus jujuba 大枣 TCMH388 ITSAM869-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT649 DRD5 Dopamine D5 receptor GPCR P21918
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1351 Nocardia sp.
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.3309
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.8962
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 10.7303
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6168
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR 10.4825
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 9.86455
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 9.80192
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 9.60763
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.299
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, GLO1, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 9.16819
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.85748
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.857
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.857
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.83217
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TEK, TYR 8.44716
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.24207
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CHRM1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 8.24207
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 8.22244
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.60391
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 7.60391
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 7.58822
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.29848
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.28289
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, DRD5, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 7.17738
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.09686
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 7.09686
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A, TYR 7.0215
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD11B1, HSD17B1, HSD17B2 6.96276
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.86444
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.8443
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.71361
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.67056
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.59568
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.5251
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 6.5251
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.51117
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.51117
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.51117
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, CHRM5, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.44672
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.41881
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, CHRM5, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.39297
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.39151
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.3914
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 6.38974
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.24757
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD5, ESR1 6.24757
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.15325
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 6.09058
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 6.05314
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.00697
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 5.92366
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 5.87677
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.87174
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 5.86876
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.86876
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 5.82647
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC 5.82504
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.73948
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CHRM1, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PTGS2, TEK 5.73451
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.70725
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.70725
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.70725
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.69287
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.69287
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 5.66395
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 5.64223
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, PTGS2, SRC, TEK 5.64223
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 5.62238
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, DRD1, DRD5, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 5.57901
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 5.54641
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 5.47614
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, NQO2, PTGS1, RORC 5.47586
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 5.47155
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.47125
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PTGS2, RORC, SRC, TYR 5.46314
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 5.45161
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.43115
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, PIK3CB, PTGS2 5.41244
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3 5.41244
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2, DRD3 5.41244
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD5, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A 5.3944
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 5.38512
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 5.37861
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.34492
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, DRD1, DRD5, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 5.23621
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 5.2204
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 5.21294
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.18329
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, DRD1, DRD2, DRD5, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.18329
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC 5.1645
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 5.12854
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.09489
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.08509
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.08509
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, KDR, SRC 5.05043
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.03205
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.89399
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.87521
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 4.8559
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.84578
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.76578
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, PTGS2, SRC, TEK 4.75569
[BP] GO:0008217 None ADORA1, DRD2, DRD3, DRD5, PPARA, PTGS1, PTGS2, SMAD3 4.70279
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, EGFR, HSPA1A 4.69116
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.64229
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, FABP3, KDR, PTGS2, SRC 4.63719
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, PPARA, RORC, SRC, TOP2A 4.60358
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.55072
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.54812
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, DRD5, PTGS2 4.54797
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.50328
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.494
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.494
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.47163
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 4.4108
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, PTGS2 4.4108
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, PTGS2 4.4108
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.39865
[BP] GO:0001963 None DRD1, DRD2, DRD3, DRD5 4.39767
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, PPARA, PTGS2, SMAD3, TEK 4.34074
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PPARA, PTGS1, PTGS2 4.33149
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.32765
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.29012
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2 4.29012
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.25869
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 4.20088
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, DRD5, EGFR, PPARA, SMAD3 4.18024
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, CDC25B, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 4.15766
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, PTGS2 4.13883
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, PTGS2 4.13883
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.12591
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.10819
[BP] GO:0045776 None ADORA1, DRD2, DRD3, DRD5, PPARA 4.10819
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, INSR, PTGS2, SMAD3 4.0691
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.05001
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.02618
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.02001
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.01572
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, DRD3, EGFR, GPR35, HCAR2, PTGS2, SMAD3 4.01572
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 4.00723
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.99756
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, PTGS2 3.99133
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, DRD1, DRD5, EGFR, PTGS2 3.97309
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 3.97309
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.96656
[BP] GO:0042325 regulation of phosphorylation ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 3.95353
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.93804
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD5, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 3.93286
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.91241
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.91022
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.89601
[BP] GO:0050890 None ADORA1, CHRM1, DRD1, DRD2, DRD3, DRD5, EGFR, INSR, PTGS2 3.88453
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.85817
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.81851
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.77254
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, KDR, SRC 3.7701
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, PTGS2, SRC 3.76786
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC 3.75057
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.71265
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.71265
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.7097
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.70448
[BP] GO:0050801 ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, FABP3, GPR35, PIK3CB, SMAD3 3.70448
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, HCAR2, INSR, PIK3CA, PIK3CB, SRC 3.70159
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.67221
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.67132
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.6683
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.65116
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC, TOP2A 3.62039
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, DRD1, DRD5, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 3.62039
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 3.62039
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.53894
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.526
[BP] GO:0031399 regulation of protein modification process ADORA1, CDC25B, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.526
[BP] GO:0001975 None DRD1, DRD2, DRD3, DRD5 3.52127
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.5067
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.5067
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 3.50276
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, PTGS2 3.47593
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.46814
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.46441
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.42314
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.41149
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DRD2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.41149
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CHRM1, CYP19A1, DRD1, DRD2, DRD3, EGFR, HCAR2, INSR, PTGS2, SMAD3, SRC 3.38364
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, DRD2, EGFR, FLT3, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.35062
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.33504
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 3.31479
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, CDC25B, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.30881
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.29977
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTGS2 3.29413
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.29244
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.29128
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.26751
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, ESR1, F3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 3.26093
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, DRD1, DRD5, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 3.23727
[BP] GO:0007191 None DRD1, DRD3, DRD5 3.22547
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22547
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET, PIK3CA 3.21663
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.20244
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.20182
[BP] GO:0098771 inorganic ion homeostasis CA12, CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, PIK3CB, SMAD3 3.20182
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3 3.20134
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, CDC25B, DRD2, DRD5, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 3.18985
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.15474
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.12809
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.1234
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.11381
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC, TEK 3.11381
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.11381
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 3.10596
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.09934
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.09934
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TOP2A 3.08529
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR 3.07128
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.03304
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APEX1, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.03304
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.02904
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.01444
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 2.98684
[BP] GO:0007212 None DRD1, DRD2, DRD3, DRD5 2.98577
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.98577
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA, SMAD3, TEK 2.97043
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, TYR 2.96851
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.96343
[BP] GO:0014075 None DRD1, DRD2, DRD3, DRD5 2.94789
[BP] GO:0046960 None DRD1, DRD5 2.93888
[BP] GO:0007612 None DRD1, DRD2, DRD3, DRD5, INSR, PTGS2 2.92419
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, EGFR, PTGS2 2.92042
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.9204
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.9204
[BP] GO:0060158 None DRD1, DRD2, DRD5 2.9204
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, DRD5, EGFR, ESR1, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC, TOP2A 2.91422
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.91422
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.88827
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.88782
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 2.8578
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 2.8578
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, GPR35, MMP9, PTGS2 2.85122
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 2.84835
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.84389
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.84389
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.84109
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.84034
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.83703
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.83703
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.83078
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.83078
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR 2.8226
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CHRM3, CYP1B1, DRD2, DRD3, EGFR, F3, HCAR2, HSPA1A, KDR, MET, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 2.82209
[BP] GO:0003008 None ADORA1, AKR1B1, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, INSR, PIK3CA, PTGS2, SRC, TEK, TYR 2.81771
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.81771
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 2.80654
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 2.80654
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.78146
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.78146
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.78146
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.75865
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.72361
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.70949
[BP] GO:0097366 None DRD1, DRD2, DRD3, DRD5 2.70762
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.67623
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.67623
[BP] GO:0007154 None ADORA1, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR2, PTGS2, TEK 2.67403
[BP] GO:0032147 activation of protein kinase activity ADORA1, DRD2, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.67212
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.67212
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR2, TEK 2.66918
[BP] GO:0055080 cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, PIK3CB, SMAD3 2.65919
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, TYR 2.64116
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.63692
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2 2.63153
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.63081
[BP] GO:0072507 divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, GPR35, PIK3CB, SMAD3 2.61512
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.60788
[BP] GO:0007611 None DRD1, DRD2, DRD3, DRD5, EGFR, INSR, PTGS2 2.60762
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD1, DRD2, DRD3, FABP3, PPARA 2.60138
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.5997
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.58608
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.55222
[BP] GO:0060160 None DRD2, DRD3 2.54795
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54795
[BP] GO:0019226 None CHRM5, DRD1, DRD5 2.54795
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.54177
[BP] GO:0055082 cellular chemical homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PIK3CA, PIK3CB, SMAD3 2.53334
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.52962
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.52962
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.52962
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.52962
[BP] GO:0009968 negative regulation of signal transduction DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.51153
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, DRD5, EGFR 2.51153
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.50547
[BP] GO:0001952 regulation of cell-matrix adhesion KDR, PIK3CB, SMAD3, SRC, TEK 2.49365
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 2.49029
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.49029
[BP] GO:0019725 cellular homeostasis APEX1, CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PIK3CA, PIK3CB, SMAD3 2.48562
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, KDR, MET, PPARA, PTGS2, RORC, SMAD3, SRC, TOP2A 2.48046
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, EGFR, FUT7, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.47919
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, PPARA, SMAD3, TEK 2.46885
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.45595
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.45355
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.45355
[BP] GO:0048148 None DRD1, DRD2, DRD3 2.43384
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.43384
[BP] GO:0031401 positive regulation of protein modification process ADORA1, CDC25B, DRD2, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 2.43336
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.43013
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, PIM1, PPARA, RORC, SRC 2.42582
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.42199
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.41976
[BP] GO:0030003 cellular cation homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PIK3CB, SMAD3 2.38288
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.38288
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.38288
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.38288
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.38132
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.38132
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, DRD2, DRD3, EGFR, HCAR2, PTGS2, PTPN1, SMAD3, SRC 2.3804
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 2.36084
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.35163
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.32899
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6 2.32899
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, ESR2, TEK 2.32478
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.32478
[BP] GO:0006873 cellular ion homeostasis CA2, CA7, DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PIK3CB, SMAD3 2.31113
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.31113
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.31113
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.31113
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31113
[BP] GO:0019229 None CHRM1, CHRM3, EGFR, PTGS2 2.31113
[BP] GO:0048731 system development ACHE, ADORA1, ALPL, CHRM1, CHRM2, CHRM3, MMP9, PIK3CA, SMAD3, SRC, TEK 2.30732
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.3069
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.28697
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, MET, PPARA, PTPN1, RORC, SMAD3, SRC, TOP2A 2.28697
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.28697
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.28697
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR 2.27345
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.27345
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APEX1, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.24469
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.2396
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PTGS2, SRC, TEK 2.23854
[BP] GO:0051894 None KDR, SMAD3, TEK 2.23854
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.23854
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, F3, FABP4, KDR, MET, PTGS2, SMAD3 2.23191
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC 2.2199
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.20517
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.19611
[BP] GO:0006874 cellular calcium ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PIK3CB, SMAD3 2.19589
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3 2.19589
[BP] GO:0050927 None F3, KDR, SMAD3 2.19142
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, SRC 2.19095
[BP] GO:0009416 response to light stimulus AURKB, DRD1, DRD2, DRD3, EGFR, PTGS2, TYR 2.18283
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.181
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, CHRM1, DRD1, DRD2, DRD3, GPR35, MMP9, PTGS2 2.17784
[BP] GO:0051246 regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.16296
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.16013
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.15663
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, F3, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH 2.1552
[BP] GO:0050926 None F3, KDR, SMAD3 2.15338
[BP] GO:1903393 None KDR, SMAD3, TEK 2.15338
[BP] GO:0010638 positive regulation of organelle organization AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.14764
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.14028
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FABP3, IGF1R, INSR, MET, PPARA, PTGS2, RORC, SMAD3, SRC, TOP2A 2.14028
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.14028
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, CDC25B, CYP1A1, DRD1, DRD2, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A 2.14028
[BP] GO:0021853 None DRD1, DRD2 2.14028
[BP] GO:0046541 None CHRM1, CHRM3 2.14028
[BP] GO:0010641 None F3, SRC 2.14028
[BP] GO:0090325 None DRD2, DRD3 2.14028
[BP] GO:1904936 None DRD1, DRD2 2.14028
[BP] GO:0042321 None ADORA1, DRD2 2.14028
[BP] GO:0055074 calcium ion homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PIK3CB, SMAD3 2.13386
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.13284
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.13284
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.12818
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, PPARA, RORC, SRC 2.12339
[BP] GO:0072503 cellular divalent inorganic cation homeostasis DRD1, DRD2, DRD3, DRD5, ESR1, GPR35, PIK3CB, SMAD3 2.10669
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, CHRM1, CHRM3, DRD2, F3, MET, XDH 2.09277
[BP] GO:0008306 None DRD1, DRD2, DRD3, DRD5 2.08842
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.08306
[BP] GO:0050877 None ADORA1, CHRM1, CHRM5, CYP1B1, DRD1, DRD2, DRD3, DRD5, EGFR, INSR, PTGS2, TYR 2.07362
[BP] GO:0007189 None DRD1, DRD2, DRD3, DRD5 2.06765
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.04199
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, RORC 2.04199
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.03467
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A 2.01109
[BP] GO:0032413 None DRD2, DRD3, GPR35, MMP9 2.00639
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.00326
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.00326
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD5, EGFR, INSR, MET, PTGS2, SRC, TEK 4.54057
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TEK 4.44049
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 4.09028
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, F3, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR 4.00445
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HCAR2, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TEK, TYR 3.83743
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, DUSP3, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTGS2, SRC, TEK 3.29489
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 3.24229
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, TEK 3.14629
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, DRD5, INSR, SRC 2.66521
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TOP2A, TYR, XDH 2.57589
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, HSD11B1, HSD17B2, PTGS1, PTGS2 2.47554
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.43013
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, EGFR, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 2.17669
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.10953
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.5099
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 14.8488
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 14.5148
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F3, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TOP2A, TYR, XDH 14.5138
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP2A 11.2592
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7458
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6168
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 8.75344
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.24207
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.24207
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 7.67126
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.59347
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 7.59202
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 7.3287
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.19205
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 7.08312
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.86182
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TYR 6.66112
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 6.66071
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 6.52622
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.51117
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 6.44672
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.41881
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 5.97076
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, GLO1, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TOP2A, TYR, XDH 5.70725
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 5.66395
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, EGFR, F3, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 5.66395
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5 5.60795
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 5.54418
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.37506
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.1645
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NQO2 5.12348
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.09383
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.92165
[MF] GO:0004952 None DRD1, DRD2, DRD3, DRD5 4.76578
[MF] GO:0035240 None DRD1, DRD2, DRD3, DRD5 4.6268
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.51008
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.494
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.3364
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD1, DRD2, DRD3, DRD5 4.25975
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.09509
[MF] GO:1901338 None DRD1, DRD2, DRD3, DRD5 3.93804
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.93286
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.53734
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.35062
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.29503
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.27632
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.17355
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 3.01444
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.98577
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.94789
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.93888
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.93888
[MF] GO:0008389 None CYP2A13, CYP2A6 2.93888
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH 2.92419
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.70442
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1 2.63081
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 2.60558
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, PPARA, RORC 2.58841
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, PPARA, RORC 2.58841
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.53334
[MF] GO:0097159 organic cyclic compound binding ADORA1, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, DRD3, DRD5, EGFR, ESR1, ESR2, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 2.43861
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.43336
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.41976
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 2.40677
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, PPARA, RORC 2.32899
[MF] GO:0001588 None DRD1, DRD5 2.31113
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.31113
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.25467
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 2.17784
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.17784
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH 2.17784
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, DRD3, DRD5, GPR35, HCAR2 2.14764
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.14028
[MF] GO:0043559 insulin binding IGF1R, INSR 2.14028
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.12818
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.12361
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.12361
[MF] GO:0042802 identical protein binding ACHE, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, SMAD3, TOP2A, TYR, XDH 2.12339
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.12339
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.04199
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.04199
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.02709


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.978
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.7387
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 8.1398
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.8251
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.2504
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.9957
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PIK3CA, ADORA1, PIK3CB, DRD1, DRD2, PPARA, DRD5 7.0209
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 6.9062
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.2195
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, ADORA3, CHRM5, ADORA1, DRD1, DRD2, DRD3, DRD5 6.9062
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.7685
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 5.4629
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, PIK3CB 5.5719
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.4501
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.2116
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR 4.8604
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, PIM1, PIK3CB, F3 4.7151
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.7151
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2946
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, TEK, PIK3CB, EGFR, IGF1R 4.6902
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, DRD1, EGFR, DRD5 4.4397
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.5869
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.5024
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.134
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R 4.1814
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.3322
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.0509
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.1814
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.3186
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.4397
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.5331
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.5315
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, PIK3CB, MMP9 3.0064
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.293
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.8697
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.5045
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.2794
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 2.7997
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.8697
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, EGFR, IGF1R 2.8554
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0214
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.7943
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.7442
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2, EGFR 2.8639
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.216
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5732
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, PTGS2, PTGS1 2.5525
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.5009
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4627
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB, HSPA1A 2.5009
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5009
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.4816
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3, DRD5 2.3956
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.4516
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.3573
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.3394
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.3181
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.2973
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.2879
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.2254
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9767
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 1.8401
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.5232
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4731
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.5009
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.8935
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2948
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3046
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.4024
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3143
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3038
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9718
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.8684
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.3021
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.343
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1518
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.8401
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3837
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.247
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 0.957
Axon guidance_Homo sapiens_hsa04360 MET 0.399
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4072
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.4516
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.029
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.5732
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.2182
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8784
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8671
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.8703
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8911
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8719
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7342
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4731
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4731
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8671
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 0.9539
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.8477
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.306
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9333
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, PIK3CB 2.3573
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4731
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4866
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.7997
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0399
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0504
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1162
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3181
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5075
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5156
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5075
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5075
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5141
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1246
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0765
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.129
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0978
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5127
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.088
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5075
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2879
Peroxisome_Homo sapiens_hsa04146 XDH 0.5156
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.1162
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.3573
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5278
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5343
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2 2.2759
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5514
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.561
Bile secretion_Homo sapiens_hsa04976 CA2 0.5588
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2765
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3198
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.2702
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5746
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5859
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2942
Shigellosis_Homo sapiens_hsa05131 SRC 0.583
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6075
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.787
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4068
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3514
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6381
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4157
Malaria_Homo sapiens_hsa05144 MET 0.6803
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6936
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5532
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6137
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6005
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8019
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7513
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8719
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8413
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8019
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8193
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8582
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9176
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8778
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8735
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8477
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7953
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8719
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1226
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2722
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0978


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)