TCM Prescription: Bi Shu Shi Tablets



Prescription Description
Prescription IDTCMF3596
Pinyin NameBi Shu Shi Pian
Chinese Name鼻舒适片
English NameBi Shu Shi Tablets
Function Description鼻渊, 鼻鼽
IndicationsAllergic rhinitis disorder, Nasal sinusitis disorder, Allergic rhinitis
Disease ICD-11 Category SC90 [Allergic rhinitis disorder (TM1), 鼻鼽 (TM1) ];
SC91 [Nasal sinusitis disorder (TM1), 鼻渊 (TM1) ];
CA08.0 [Allergic rhinitis, 变应性鼻炎 ];
Human Tissues Associated with IndicationNose
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH206 Fructus xanthii sibirici 苍耳子 TCMH206 KJ496390
TCMH2452 Chrysanthemum indicum 野菊花 TCMH2452 ITSAB1463-14
TCMH536 Centipeda minima 鹅不食草 TCMH536 ITSAJ4316-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH404 Rhizoma arisaema cum bile 胆南星 TCMH404
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1024 Tribulus terrestris 蒺藜 TCMH1024 ITSAJ4258-14
TCMH1631 Chlorpheniramini maleas 扑尔敏 TCMH1631
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT244 HRH1 Histamine H1 receptor GPCR P35367
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1184 Mycobacterium fortuitum
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1198 Serratia marcescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1261 Pseudomonas savastanoi pv. savastanoi
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1352 Colletotrichum truncatum
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1394 Mycobacterium aurum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 10.9654
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.20849
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.16258
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 9.12362
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 7.01795
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HASPIN, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 7.01795
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 6.98423
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.9799
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TNKS 6.9799
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 6.9799
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, NISCH, PIM1, PPARA, TYR, XDH 6.92014
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.5996
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HRH1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOA, MCL1, MET, NISCH, PPARA, SRC, TNKS, TNKS2, XDH 6.3696
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 6.3696
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HRH1, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, MMP2, PPARA, SRC, TYR 6.33952
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, SRC, TYR 6.27887
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.98795
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, DYRK3, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MCL1, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TNKS2, TYR 5.83138
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, TYR, XDH 5.81268
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F10, F3, FLT3, HRH1, IGF1R, KDR, MCL1, MET, MMP12, MMP9, NISCH, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 5.77089
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HRH1, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 5.76924
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC, TNKS 5.73458
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F10, F3, FLT3, HRH1, IGF1R, KDR, MCL1, MET, MMP12, MMP9, NISCH, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 5.68132
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.68132
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HRH1, HSD11B2, SRC, TYR 5.50918
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.3389
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.33513
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HRH1, HSD11B2, IGF1R, MMP2, PPARA, SRC 5.33513
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 5.33513
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.28375
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, FLT3, HASPIN, IGF1R, KDR, MET, SRC, TNKS 5.27834
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HRH1, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, MMP2, MMP9, PPARA, SRC, TYR 5.26298
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, F3, FLT3, FUT7, GBA2, HASPIN, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 5.18864
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 5.02649
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, PTPRS, SRC, TYR 4.9588
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HRH1, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 4.87092
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, PIM1, SRC 4.85181
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 4.85082
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.81286
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, F10, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH 4.72587
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MCL1, MMP9, PIM1, PPARA, PTPRS, SRC, TYR 4.71983
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.68413
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, SRC 4.5391
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.53857
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.51758
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.50111
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.39439
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.24119
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.22121
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, NISCH, SRC 4.2057
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, DYRK3, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.17312
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.12669
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, GBA2, MET, PPARA 4.11149
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.11066
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.10188
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, HRH1, HSD11B2, HSD17B2, IGF1R, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TYR 4.08688
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, IGF1R, KDR, MCL1, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.02656
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.98993
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, DYRK3, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC 3.97222
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, NISCH, SRC 3.84514
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, NISCH, SRC 3.83559
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, NISCH, SRC 3.83559
[BP] GO:0018210 peptidyl-threonine modification BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.80833
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, F3, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2 3.79255
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, DYRK1A, DYRK3, ESR1, F3, FABP4, IGF1R, MCL1, MET, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, XDH 3.78051
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, ESR1, F3, FLT3, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC, XDH 3.60876
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.58006
[BP] GO:0010676 None DYRK2, ESRRB, HRH1, PPARA, SRC 3.57243
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, F10, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.57243
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, KDR, MCL1, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 3.55983
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.51655
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.49386
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.49386
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.49386
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MCL1, MET, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.48378
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.48337
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, F10, F3, FLT3, KDR, MCL1, MET, PTPN1, SRC, XDH 3.46089
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, DYRK3, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC 3.41816
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.4079
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, MAOA, TYR 3.36007
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TNKS, TNKS2 3.36007
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, DYRK3, ESR1, IGF1R, MCL1, MET, MMP9, PTPN1, SRC, XDH 3.35764
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 3.27011
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.22712
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HRH1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.22389
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HRH1, IGF1R, KDR, MMP2, MMP9, SRC 3.14971
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, SRC, XDH 3.1491
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2 3.11558
[BP] GO:0045913 None DYRK2, ESRRB, HRH1, PPARA, SRC 3.09526
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2 3.07094
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2 3.07094
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, NISCH 3.06106
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.05586
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HRH1, IGF1R, KDR, MMP2, SRC 3.03928
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.02427
[BP] GO:0010907 None DYRK2, ESRRB, PPARA, SRC 3.01909
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.99464
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HRH1, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.98578
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MCL1, MET, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 2.95799
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.929
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, KDR, SRC, TNKS, TNKS2 2.9228
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PPARA 2.89404
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.85412
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DYRK2, ESR1, FABP4, FLT3, HRH1, IGF1R, KDR, MCL1, MMP2, MMP9, PTPN1, SRC 2.84582
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DYRK2, F10, F3, IGF1R, KDR, MET, MMP12, MMP9, NISCH, PPARA, PTPN1, SRC 2.84309
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DYRK2, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HRH1, HSD11B2, HSD17B2, IGF1R, KDR, MCL1, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TYR 2.81326
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, XDH 2.79785
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, XDH 2.78383
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74581
[BP] GO:0009115 None AOX1, XDH 2.74581
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.67613
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.656
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DYRK1A, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.61324
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.58807
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, MAOA 2.58755
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CLK1, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 2.53743
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MMP9, PTPN1, SRC 2.49606
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.49509
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.49509
[BP] GO:0043412 macromolecule modification ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2 2.44644
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DYRK1A, DYRK1B, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.44398
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, CLK1, DYRK1A, SRC, TNKS 2.4263
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.42602
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.42602
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.4044
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DYRK3, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MCL1, MET, MMP2, MMP9, PTPRS, SRC 2.39359
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.39154
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.36139
[BP] GO:0046110 None AOX1, XDH 2.33741
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.33741
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, HRH1, SRC 2.33741
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.33232
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.33089
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.32644
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HASPIN, HRH1, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 2.32495
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.31594
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.31378
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.29314
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.29314
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.25878
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.25032
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, CLK1, DYRK1A, SRC, TNKS 2.22486
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, TYR 2.21601
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DYRK2, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 2.20953
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HRH1, HSD11B2, MMP2, PPARA, SRC, TYR 2.20953
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DYRK1B, DYRK2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HRH1, IGF1R, KDR, MET, MMP12, PPARA, SRC, TNKS, TNKS2 2.20437
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, SRC 2.16625
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 2.16625
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.15737
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.15528
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DYRK2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HASPIN, HRH1, IGF1R, KDR, MCL1, MET, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 2.1216
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, ESR1, PPARA, SRC 2.11455
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.11455
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.11455
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11455
[BP] GO:0070213 None TNKS, TNKS2 2.11455
[BP] GO:0006145 None AOX1, XDH 2.11455
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.11455
[BP] GO:0009968 negative regulation of signal transduction BCL2, DYRK1A, DYRK3, ESR1, ESR2, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, XDH 2.11455
[BP] GO:0010675 None DYRK2, ESRRB, HRH1, PPARA, SRC 2.11455
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, HASPIN, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 2.09266
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.08105
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, FABP3, FLT3, HRH1, HSD11B2, IGF1R, MMP2, PPARA, SRC, TYR 2.07872
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, SRC 2.07872
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.07872
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.07872
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MCL1, MET, SRC 2.06803
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.06653
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.02386
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HRH1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MAOA, MCL1, MMP2, MMP9, NISCH, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 2.58988
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HASPIN, IGF1R, KDR, MAOA, MCL1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 2.38293
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.25802
[CC] GO:0031233 None CA4, F10, F3 2.25784
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.80765
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 14.7028
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, F3, FLT3, FUT7, GBA2, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 13.615
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NISCH, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 11.1469
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.78218
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, IGF1R, KDR, MET, SRC 7.01795
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, TYR, XDH 6.9799
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.3696
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.01429
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 6.00842
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.92553
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, TNKS 5.68132
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.43895
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.33513
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.302
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 5.23789
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 5.16495
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.12328
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, PPARA, SRC 5.08309
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 4.9588
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.72587
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 4.7235
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.13588
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, F3, FLT3, HASPIN, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC 4.02656
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.97222
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 3.88429
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.83559
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 3.79255
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.79255
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, NISCH, PPARA 3.72719
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.68491
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.68491
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, SRC, XDH 3.57243
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, F10, F3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, IGF1R, KDR, MET, NISCH, PIM1, PTPRS, SRC, XDH 3.53209
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.51655
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.36007
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.31798
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.267
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.20697
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.10424
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, HASPIN, PIM1 3.06847
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.9754
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FABP3, FABP4, FLT3, HASPIN, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, XDH 2.88059
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.83683
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SRC 2.8203
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.74581
[MF] GO:0003845 None HSD11B1, HSD11B2 2.74581
[MF] GO:0008389 None CYP2A13, CYP2A6 2.74581
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.58807
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SRC 2.47982
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, XDH 2.34773
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, XDH 2.34716
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.29314
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, ESR1, ESR2, FLT3, IGF1R, KDR, MCL1, MET, MMP9, NISCH, TYR, XDH 2.22833
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 2.19554
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP12, MMP2, MMP9 2.11903
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.11455
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 2.10911
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, FLT3, HASPIN, IGF1R, KDR, MET, PIM1, SRC 2.08105


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.9027
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.7595
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7086
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.6486
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.4021
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.3884
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.2648
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.0098
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B, MCL1 3.934
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0251
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.1402
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.5667
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8315
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.1307
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1 3.0835
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.4942
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0835
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.303
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, MCL1, IGF1R 2.0855
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.9606
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1, MCL1 1.8914
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9201
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9201
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.7147
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7212
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.5239
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, ALOX5 1.5061
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2865
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4374
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.1936
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.191
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9129
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1583
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1388
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.945
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1743
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9367
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1244
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 HRH1, SRC 0.9129
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.963
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9129
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0218
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.156
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1224
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.8548
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0212
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9285
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8901
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8548
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8342
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HRH1, ADORA3, ADORA1 0.8024
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3316
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.838
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.838
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.838
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.7585
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.765
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8142
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6082
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7585
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7582
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.6702
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6362
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5909
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.5909
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5061
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5909
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5683
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2267
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2729
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3164
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.326
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3104
Calcium signaling pathway_Homo sapiens_hsa04020 HRH1 0.3158
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3158
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.326
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3102
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.356
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3527
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3411
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3664
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3702
Platelet activation_Homo sapiens_hsa04611 SRC 0.3919
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3817
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3925
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3817
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3919
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3919
Axon guidance_Homo sapiens_hsa04360 MET 0.3871
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.3853
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4196
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4466
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4466
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4665
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8044
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4578
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4577
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4658
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4577
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4665
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.466
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4665
Gap junction_Homo sapiens_hsa04540 SRC 0.4665
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4662
Peroxisome_Homo sapiens_hsa04146 XDH 0.472
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5123
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5113
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5198
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5294
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5294
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5294
Bile secretion_Homo sapiens_hsa04976 CA2 0.5187
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.528
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.521
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.539
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5294
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1457
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5309
Shigellosis_Homo sapiens_hsa05131 SRC 0.5294
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5613
Legionellosis_Homo sapiens_hsa05134 CLK1 0.5635
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5909
Malaria_Homo sapiens_hsa05144 MET 0.5909
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.5909
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5909
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5885
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5909
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5909
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6362
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6343
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7158
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7375
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7375
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7585
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7552
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7662
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8548
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.838
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9059
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1482


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)